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https://www.readbyqxmd.com/read/29684583/a-novel-rpe65-inhibitor-cu239-suppresses-visual-cycle-and-prevents-retinal-degeneration
#1
Younghwa Shin, Gennadiy Moiseyev, Konstantin Petrukhin, Christopher L Cioffi, Parthasarathy Muthuraman, Yusuke Takahashi, Jian-Xing Ma
The retinoid visual cycle is an ocular retinoid metabolism specifically dedicated to support vertebrate vision. The visual cycle serves not only to generate light-sensitive visual chromophore 11-cis-retinal, but also to clear toxic byproducts of normal visual cycle (i.e. all-trans-retinal and its condensation products) from the retina, ensuring both the visual function and the retinal health. Unfortunately, various conditions including genetic predisposition, environment and aging may attribute to a functional decline of the all-trans-retinal clearance...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684540/chemical-composition-antioxidant-anticholinesterase-antimicrobial-and-antibiofilm-activities-of-essential-oil-and-methanolic-extract-of-anthemis-stiparum-subsp-sabulicola-pomel-oberpr
#2
Ahmed Elkhalifa Chemsa, Amar Zellagui, Mehmet Öztürk, Ebru Erol, Ozgür Ceylan, Mehmet Emin Duru, Mesbah Lahouel
Anthemis species are traditionally used to treat infectious and inflammatory processes, among others clinical disturbances. In the current study, the chemical composition, the total phenolic and flavonoid contents, the antioxidant, anticholinesterase, antimicrobial, and antibiofilm activities of Anthemis stiparum subsp. sabulicola aerial parts methanolic extract (As-ME) and essential oil (As-EO) were investigated. The chemical composition of As-EO was established by GC-MS and GC-FID. Total phenolic and flavonoid contents of As-ME were spectrophotometrically determined...
April 20, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29683407/effect-of-er-cr-ysgg-laser-and-ascorbic-acid-on-the-bond-strength-and-microleakage-of-bleached-enamel-surface
#3
Fahad Alkhudhairy, Abdulaziz AlKheraif, Mohammed Bin-Shuwaish, Sulieman Al-Johany, Mustafa Naseem, Fahim Vohra
BACKGROUND: The available evidence of Er,Cr:YSGG lasers on bleached enamel is limited and controversial. It is assumed that Er,Cr:YSGG laser will be effective in reversing the effect of bleaching on adhesive bond integrity of enamel to resin composite. OBJECTIVE: The study aimed to evaluate the efficacy of Er,Cr:YSGG laser on bond strength and microleakage of bleached enamel. MATERIALS AND METHODS: From the 80 samples, 60 samples were bleached (40% hydrogen peroxide) and divided into three subgroups...
April 23, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29682653/single-photon-emission-from-plasma-treated-2d-hexagonal-boron-nitride
#4
Zai-Quan Xu, Christopher Elbadawi, Toan Trong Tran, Mehran Kianinia, Xiuling Li, Daobin Liu, Timothy B Hoffman, Minh Nguyen, Sejeong Kim, James H Edgar, Xiaojun Wu, Li Song, Sajid Ali, Mike Ford, Milos Toth, Igor Aharonovich
Artificial atomic systems in solids are becoming increasingly important building blocks in quantum information processing and scalable quantum nanophotonic networks. Amongst numerous candidates, 2D hexagonal boron nitride has recently emerged as a promising platform hosting single photon emitters. Here, we report a number of robust plasma and thermal annealing methods for fabrication of emitters in tape-exfoliated hexagonal boron nitride (hBN) crystals. A two-step process comprising Ar plasma etching and subsequent annealing in Ar is highly robust, and yields an eight-fold increase in the concentration of emitters in hBN...
April 23, 2018: Nanoscale
https://www.readbyqxmd.com/read/29682405/symbiotic-immuno-suppression-is-disease-susceptibility-the-price-of-bleaching-resistance
#5
Daniel G Merselis, Diego Lirman, Mauricio Rodriguez-Lanetty
Accelerating anthropogenic climate change threatens to destroy coral reefs worldwide through the processes of bleaching and disease. These major contributors to coral mortality are both closely linked with thermal stress intensified by anthropogenic climate change. Disease outbreaks typically follow bleaching events, but a direct positive linkage between bleaching and disease has been debated. By tracking 152 individual coral ramets through the 2014 mass bleaching in a South Florida coral restoration nursery, we revealed a highly significant negative correlation between bleaching and disease in the Caribbean staghorn coral, Acropora cervicornis ...
2018: PeerJ
https://www.readbyqxmd.com/read/29680291/novel-color-additive-for-chlorine-disinfectants-corrects-deficiencies-in-spray-surface-coverage-and-wet-contact-time-and-checks-for-correct-chlorine-concentration
#6
Kevin Tyan, Katherine Jin, Jason Kang, Aaron M Kyle
Bleach sprays suffer from poor surface coverage, dry out before reaching proper contact time, and can be inadvertently over-diluted to ineffective concentrations. Highlight® , a novel color additive for bleach that fades to indicate elapsed contact time, maintained >99.9% surface coverage over full contact time and checked for correct chlorine concentration.
April 18, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29679712/evaluating-the-genotoxicity-of-cellulose-nanofibrils-in-a-co-culture-of-human-lung-epithelial-cells-and-monocyte-derived-macrophages
#7
Célia Ventura, Ana Filipa Lourenço, António Sousa-Uva, Paulo J T Ferreira, Maria João Silva
Cellulose nanofibrils (CNF) are manufactured nanofibres that hold impressive expectations in forest, food, pharmaceutical, and biomedical industries. CNF production and applications are leading to an increased human exposure and thereby it is of utmost importance to assess its safety to health. In this study, we screened the cytotoxic, immunotoxic and genotoxic effects of a CNF produced by TEMPO-mediated oxidation of an industrial bleached Eucalyptus globulus kraft pulp on a co-culture of lung epithelial alveolar (A549) cells and monocyte-derived macrophages (THP-1 cells)...
April 18, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29679230/dental-bleaching-on-teeth-submitted-to-enamel-microabrasion-30-years-ago-a-case-report-of-patients-compliance-during-bleaching-treatment
#8
Daniel Sundfeld, Caio Cesar Pavani, Timm Cornelius Schott, Lucas Silveira Machado, Núbia Inocêncya Pavesi Pini, André Pinheiro de Magalhães Bertoz, Renato Herman Sundfeld
OBJECTIVES: The present dental bleaching case report describes a new method that precisely quantifies the daily wearing-times of the bleaching product by inserting a microsensor in the acetate custom tray. The bleaching efficacy was also discussed since the patient was previously submitted to enamel microabrasion. METHODS: The patient was submitted to enamel microabrasion in 1987, and bleaching treatment was performed in 2005. In 2017, re-bleaching was executed using 10% peroxide carbamide...
April 20, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29679054/quantitative-diffusion-measurements-using-the-open-source-software-pyfrap
#9
Alexander Bläßle, Gary Soh, Theresa Braun, David Mörsdorf, Hannes Preiß, Ben M Jordan, Patrick Müller
Fluorescence Recovery After Photobleaching (FRAP) and inverse FRAP (iFRAP) assays can be used to assess the mobility of fluorescent molecules. These assays measure diffusion by monitoring the return of fluorescence in bleached regions (FRAP), or the dissipation of fluorescence from photoconverted regions (iFRAP). However, current FRAP/iFRAP analysis methods suffer from simplified assumptions about sample geometry, bleaching/photoconversion inhomogeneities, and the underlying reaction-diffusion kinetics. To address these shortcomings, we developed the software PyFRAP, which fits numerical simulations of three-dimensional models to FRAP/iFRAP data and accounts for bleaching/photoconversion inhomogeneities...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29676980/effect-of-bleaching-gel-viscosity-on-tooth-whitening-efficacy-and-pulp-chamber-penetration-an-in-vitro-study
#10
S R Kwon, Fnu Pallavi, Y Shi, U Oyoyo, A Mohraz, Y Li
OBJECTIVES: Whitening efficacy has been related to hydrogen peroxide (HP) diffusion into tooth structure. However, little information is available relating rheological properties to whitening efficacy. The purpose was to evaluate the whitening efficacy and HP penetration level of a 10% HP gel at three different viscosities and to compare them to a strip delivery system. METHODS AND MATERIALS: Extracted molars (n=120) were randomly assigned into five groups (n=24/ group): NC_MED (negative control; median): medium viscosity gel without HP; LOW: 10% HP gel (low viscosity experimental gel, Ultradent Products Inc); MED: 10% HP gel (medium viscosity experimental gel, Ultradent); HIGH: 10% HP gel (high viscosity gel, Ultradent); and CWS: Crest 3D Whitestrips 1-Hour Express (Procter & Gamble)...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29676979/effectiveness-of-and-dental-sensitivity-to-at-home-bleaching-with-4-and-10-hydrogen-peroxide-a-randomized-triple-blind-clinical-trial
#11
K Chemin, M Rezende, A D Loguercio, A Reis, S Kossatz
OBJECTIVES: To evaluate the risk for and intensity of tooth sensitivity and color change of at-home dental bleaching with 4% and 10% hydrogen peroxide (HP). METHODS: For this study, 78 patients were selected according to the inclusion and exclusion criteria and randomized into two groups: HP 4 (White Class 4%, FGM) and HP 10 (White Class 10%, FGM). In both groups, the at-home bleaching was performed for a period of 30 minutes twice a day for two weeks. The color was assessed by Vita Classical, Vita Bleachedguide 3D-MASTER and spectrophotometer Vita Easyshade (Vita Zahnfabrik) at baseline, during bleaching (first and second weeks) and after bleaching (one month)...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29673352/a-multifunctional-targeting-probe-with-dual-mode-imaging-and-photothermal-therapy-used-in-vivo
#12
Xiao-Shuai Zhang, Yang Xuan, Xiao-Quan Yang, Kai Cheng, Ruo-Yun Zhang, Cheng Li, Fang Tan, Yuan-Cheng Cao, Xian-Lin Song, Jie An, Xiao-Lin Hou, Yuan-Di Zhao
BACKGROUND: Ag2 S has the characteristics of conventional quantum dot such as broad excitation spectrum, narrow emission spectrum, long fluorescence lifetime, strong anti-bleaching ability, and other optical properties. Moreover, since its fluorescence emission is located in the NIR-II region, has stronger penetrating ability for tissue. Ag2 S quantum dot has strong absorption during the visible and NIR regions, it has good photothermal and photoacoustic response under certain wavelength excitation...
April 19, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29672556/in-situ-observations-of-coral-bleaching-in-the-central-saudi-arabian-red-sea-during-the-2015-2016-global-coral-bleaching-event
#13
Alison A Monroe, Maren Ziegler, Anna Roik, Till Röthig, Royale S Hardenstine, Madeleine A Emms, Thor Jensen, Christian R Voolstra, Michael L Berumen
Coral bleaching continues to be one of the most devastating and immediate impacts of climate change on coral reef ecosystems worldwide. In 2015, a major bleaching event was declared as the "3rd global coral bleaching event" by the United States National Oceanic and Atmospheric Administration, impacting a large number of reefs in every major ocean. The Red Sea was no exception, and we present herein in situ observations of the status of coral reefs in the central Saudi Arabian Red Sea from September 2015, following extended periods of high temperatures reaching upwards of 32...
2018: PloS One
https://www.readbyqxmd.com/read/29672529/potential-and-limits-for-rapid-genetic-adaptation-to-warming-in-a-great-barrier-reef-coral
#14
Mikhail V Matz, Eric A Treml, Galina V Aglyamova, Line K Bay
Can genetic adaptation in reef-building corals keep pace with the current rate of sea surface warming? Here we combine population genomics, biophysical modeling, and evolutionary simulations to predict future adaptation of the common coral Acropora millepora on the Great Barrier Reef (GBR). Genomics-derived migration rates were high (0.1-1% of immigrants per generation across half the latitudinal range of the GBR) and closely matched the biophysical model of larval dispersal. Both genetic and biophysical models indicated the prevalence of southward migration along the GBR that would facilitate the spread of heat-tolerant alleles to higher latitudes as the climate warms...
April 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29671321/a-comparative-metabolomics-approach-detects-stress-specific-responses-during-coral-bleaching-in-soft-corals
#15
Mohamed A Farag, Achim Meyer, Sara E Ali, Mohamed A Salem, Patrick Giavalisco, Hildegard Westphal, Ludger A Wessjohann
Chronic exposure to ocean acidification and elevated sea-surface temperatures pose significant stress to marine ecosystems. This in turn necessitates costly acclimation responses in corals in both the symbiont and host, with a re-organization of cell metabolism and structure. A large-scale untargeted metabolomics approach comprising gas chromatography mass spectrometry (GC-MS) and ultra performance liquid chromatography coupled to high resolution mass spectrometry (UPLC-MS) was applied to profile the metabolite composition of the soft coral Sarcophyton ehrenbergi and its dinoflagellate symbiont...
April 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29670846/evaluation-of-volatile-profile-fatty-acids-composition-and-in-vitro-bioactivity-of-tagetes-minuta-growing-wild-in-northern-iran
#16
Farshid Rezaei, Rashid Jamei, Reza Heidari
Purpose: The aim of the present study was to investigate the chemical properties of wild Tagetes minuta L. (family Astreacea) collected from Northern Iran during the flowering period concerning the chemical combination of the essential oil along with its antioxidant properties and composition of fatty acids. Methods: The essential oil of the plant was extracted by a Clevenger approach and analyzed using gas chromatography-mass spectroscopy (Capillary HP-5ms GC/MS Column). Fatty acid contents of this species as a result of hexane extraction were analyzed by means of gas chromatography (GC-FID) while their phenolic contents were analyzed by high performance liquid chromatography (HPLC-UV)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670282/global-warming-transforms-coral-reef-assemblages
#17
Terry P Hughes, James T Kerry, Andrew H Baird, Sean R Connolly, Andreas Dietzel, C Mark Eakin, Scott F Heron, Andrew S Hoey, Mia O Hoogenboom, Gang Liu, Michael J McWilliam, Rachel J Pears, Morgan S Pratchett, William J Skirving, Jessica S Stella, Gergely Torda
Global warming is rapidly emerging as a universal threat to ecological integrity and function, highlighting the urgent need for a better understanding of the impact of heat exposure on the resilience of ecosystems and the people who depend on them 1 . Here we show that in the aftermath of the record-breaking marine heatwave on the Great Barrier Reef in 2016 2 , corals began to die immediately on reefs where the accumulated heat exposure exceeded a critical threshold of degree heating weeks, which was 3-4 °C-weeks...
April 18, 2018: Nature
https://www.readbyqxmd.com/read/29669898/multi-omics-analysis-of-thermal-stress-response-in-a-zooxanthellate-cnidarian-reveals-the-importance-of-associating-with-thermotolerant-symbionts
#18
Maha J Cziesielski, Yi Jin Liew, Guoxin Cui, Sebastian Schmidt-Roach, Sara Campana, Claudius Marondedze, Manuel Aranda
Corals and their endosymbiotic dinoflagellates of the genus Symbiodinium have a fragile relationship that breaks down under heat stress, an event known as bleaching. However, many coral species have adapted to high temperature environments such as the Red Sea (RS). To investigate mechanisms underlying temperature adaptation in zooxanthellate cnidarians we compared transcriptome- and proteome-wide heat stress response (24 h at 32°C) of three strains of the model organism Aiptasia pallida from regions with differing temperature profiles; North Carolina (CC7), Hawaii (H2) and the RS...
April 25, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29666437/increasing-thermal-stress-for-tropical-coral-reefs-1871-2017
#19
J M Lough, K D Anderson, T P Hughes
Tropical corals live close to their upper thermal limit making them vulnerable to unusually warm summer sea temperatures. The resulting thermal stress can lead to breakdown of the coral-algal symbiosis, essential for the functioning of reefs, and cause coral bleaching. Mass coral bleaching is a modern phenomenon associated with increases in reef temperatures due to recent global warming. Widespread bleaching has typically occurred during El Niño events. We examine the historical level of stress for 100 coral reef locations with robust bleaching histories...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661322/cellulose-nanofibers-isolated-by-tempo-oxidation-and-aqueous-counter-collision-methods
#20
Le Van Hai, Lindong Zhai, Hyun Chan Kim, Jung Woong Kim, Eun Sik Choi, Jaehwan Kim
In this research, cellulose nanofiber (CNF) was isolated by the combination of chemical 2,2,6,6-tetramethylpiperidine-1-oxylradical (TEMPO)-oxidation and physical aqueous counter collision (ACC) methods The combination of TEMPO-oxidation and ACC is an efficient method to isolate CNFs by reducing chemical usage in TEMPO-oxidation and saving energy in ACC along with controlling the size of CNFs. Two cellulose sources, hardwood bleached kraft pulp (HW) and softwood bleached kraft pulp (SW), were used for the CNF isolation with different TEMPO oxidation time and a defined number of ACC pass...
July 1, 2018: Carbohydrate Polymers
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