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https://www.readbyqxmd.com/read/28192982/novel-double-potential-electrochemiluminescence-ratiometric-strategy-in-enzyme-based-inhibition-biosensing-for-sensitive-detection-of-organophosphorus-pesticides
#1
Hongmei Chen, Han Zhang, Ruo Yuan, Shihong Chen
Generally, electrochemiluminescence (ECL) ratiometric assays were based on the energy transfer (ET) between an emitter and a metal nanomaterial or between two different emitters. The choice of suitable energy donor-acceptor pair and the distance dependence of ET would greatly limit the practical application of ratiometric assays. This work explored a novel double-potential ECL ratiometry without the ET for organophosphorus pesticides (OPs) analysis, in which, reduced graphene oxide-CdTe quantum dots (RGO-CdTe QDs) and carboxyl-conjugated polymer dots (PFO dots) were chosen as cathodic and anodic ECL emitters, and the reactant (dissolved O2) and the product (H2O2) in enzymatic reactions served as their coreactants, respectively...
February 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28181217/hypercoagulability-and-migraine
#2
Gretchen E Tietjen, Stuart A Collins
BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms...
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28176181/transthoracic-contrast-echocardiography-using-vitamin-b6-and-sodium-bicarbonate-as-contrast-agents-for-the-diagnosis-of-patent-foramen-ovale
#3
Jiang-Chun He, Jian-Yong Zheng, Xin Li, Ye Yang, Bo-Yang Zhang, Yu Chen, Xian-Feng Li, Ying-Ming Liu, Yi Cao, Li Zhao, Tian-Chang Li
To evaluate the utility of transthoracic contrast echocardiography (cTTE) using vitamin B6 and sodium bicarbonate as contrast agents for diagnosing right-to-left shunt (RLS) caused by patent foramen ovale (PFO) compared to that of transesophageal echocardiography (TEE). We investigated 125 patients admitted to our neurology department with unexplained cerebral infarction and migraine. All patients underwent cTTE using vitamin B6 and sodium bicarbonate as contrast agents, after which they underwent transthoracic echocardiography...
February 7, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28167768/high-resolution-imaging-and-quantification-of-plasma-membrane-cholesterol-by-nanosims
#4
Cuiwen He, Xuchen Hu, Rachel S Jung, Thomas A Weston, Norma P Sandoval, Peter Tontonoz, Matthew R Kilburn, Loren G Fong, Stephen G Young, Haibo Jiang
Cholesterol is a crucial lipid within the plasma membrane of mammalian cells. Recent biochemical studies showed that one pool of cholesterol in the plasma membrane is "accessible" to binding by a modified version of the cytolysin perfringolysin O (PFO*), whereas another pool is sequestered by sphingomyelin and cannot be bound by PFO* unless the sphingomyelin is destroyed with sphingomyelinase (SMase). Thus far, it has been unclear whether PFO* and related cholesterol-binding proteins bind uniformly to the plasma membrane or bind preferentially to specific domains or morphologic features on the plasma membrane...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28143995/ebstein-anomaly-in-pregnancy
#5
Lusiani Rusdi, Syahrir Azizi, Christopher Suwita, Astrid Karina, Sally A Nasution
: A 27-year-old primiparous woman with 28 weeks gestational age was admitted to our hospital with worsening shortness of breath. She was diagnosed with Ebstein's anomaly three years ago, but preferred to be left untreated. The patient was not cyanotic and her vital signs were stable. Her ECG showed incomplete RBBB and prolonged PR-interval. Blood tests revealed mild anemia. Observation of two-dimensional echo with color flow Doppler study showed Ebstein's anomaly with PFO as additional defects, EF of 57%, LV and LA dilatation, RV atrialization, severe TR, and moderate PH with RVSP of 44...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28123762/percutaneous-pfo-closure-for-cryptogenic-stroke-in-the-setting-of-a-systematic-cardiac-and-neurological-screening-and-a-standardised-follow-up-protocol
#6
Stéphane Noble, Robert F Bonvini, Fabio Rigamonti, Roman Sztajzel, Fabienne Perren, Philippe Meyer, Hajo Müller, Marco Roffi
BACKGROUND: There are no uniform workup and follow-up (FU) protocols for patients presenting with cryptogenic embolism (CE) who undergo percutaneous closure of a patent foramen ovale (PFO). METHODS: We prospectively performed a systematic cardiac and neurological FU protocol in all patients who underwent percutaneous PFO closure in order to assess the incidence of subsequent cardiac and neurological adverse events. All patients received dual antiplatelet therapy for 6 months and were systematically included in a 12-month standardised FU protocol including: clinical evaluation-transthoracic and transoesophageal echocardiography, 24-hour Holter monitoring and/or 1-week R-test, and transcranial Doppler...
2017: Open Heart
https://www.readbyqxmd.com/read/28116864/pfo-closure-end-of-an-era-or-beginning-of-a-new-chapter
#7
EDITORIAL
Mahmoud I Traina, E Murat Tuzcu
This large long-term retrospective cohort study shows that percutaneous patent foramen ovale (PFO) closure is safe. Higher rates of recurrent stroke or TIA were noted in older patients (age>55) and those with diabetes and hypertension Randomized trials have failed to show significant benefit from PFO closure for cryptogenic stroke though pooled analyses and longer-term follow-up have revealed significant reduction in recurrent strokes. Future studies and longer-term follow-up will need to elucidate which subgroups of patients will benefit from closure...
January 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28106717/air-embolism-diagnosis-clinical-management-and-outcomes
#8
Colin J McCarthy, Sasan Behravesh, Sailendra G Naidu, Rahmi Oklu
Air embolism is a rare but potentially fatal complication of surgical procedures. Rapid recognition and intervention is critical for reducing morbidity and mortality. We retrospectively characterized our experience with air embolism during medical procedures at a tertiary medical center. Electronic medical records were searched for all cases of air embolism over a 25-year period; relevant medical and imaging records were reviewed. Sixty-seven air embolism cases were identified; the mean age was 59 years (range, 3-89 years)...
January 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/28106015/relationship-between-mean-platelet-volume-and-ischemic-stroke-in-patients-with-patent-foramen-ovale
#9
Nermin Bayar, Selçuk Küçükseymen, Zehra Erkal, Ramazan Güven, Erkan Köklü, Çağın Mustafa Üreyen, Şakir Arslan
OBJECTIVE: Patent foramen ovale (PFO) is commonly encountered in patients with cryptogenic stroke. Mean platelet volume (MPV), an indicator of platelet reactivity, has been reported in recent trials to be higher in patients with PFO than in normal population. The aim of this study was to investigate whether there is a difference in MPV between patients with PFO and stroke or transient ischemic attack (TIA) and that of patients with asymptomatic PFO. METHODS: Patients with PFO who were younger than 55 years of age were enrolled in this retrospective study...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28088807/posterior-versus-anterior-circulation-stroke-in-young-adults-a-comparative-study-of-stroke-aetiologies-and-risk-factors-in-stroke-among-young-fabry-patients-sifap1
#10
Bettina von Sarnowski, Ulf Schminke, Ulrike Grittner, Christian Tanislav, Tobias Böttcher, Michael G Hennerici, Turgut Tatlisumak, Jukka Putaala, Manfred Kaps, Franz Fazekas, Christian Enzinger, Arndt Rolfs, Christof Kessler
BACKGROUND: Although 20-30% of all strokes occur in the posterior circulation, few studies have explored the characteristics of patients with strokes in the posterior compared to the anterior circulation so far. Especially data on young patients is missing. METHODS: In this secondary analysis of data of the prospective multi-centre European sifap1 study that investigated stroke and transient ischemic attack (TIA) patients aged 18-55 years, we compared vascular risk factors, stroke aetiology, presence of white matter hyperintensities (WMH) and cerebral microbleeds (CMB) between patients with ischaemic posterior circulation stroke (PCS) and those having suffered from anterior circulation stroke (ACS) based on cerebral MRI...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28057648/in-vitro-experiment-to-elucidate-the-mechanism-of-the-soft-shell-technique-for-preventing-subretinal-migration-of-perfluoro-octane
#11
Yau Kei Chan, Yongjie Lu, Gabriela Czanner, Jing Wu, Ho Ching Cheng, Rumana Hussain, Taiji Sakamoto, Ho Cheung Shum, David Wong
AIM: Perfluorocarbon liquid (PFCL) can migrate into subretinal space in detached and stiffened retina with open holes during vitreoretinal surgery. An innovative 'soft shell' technique was introduced to reduce the complication using hyaluronate (HA) to 'cover' the retinal hole. This study aims to study the effectiveness of this technique in vitro. METHODS: Ex vivo porcine retina was mounted on a transwell insert. Beneath the retina was an aqueous solution. Two retinal holes were made using needle punctures...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28028400/transcatheter-closure-of-patent-foramen-ovale-a-single-center-experience
#12
Ivan Milev, Planinka Zafirovska, Zan Zimbakov, Shpend Idrizi, Vilma Ampova-Sokolov, Emilija Gorgieva, Liljana Ilievska, Goce Tosheski, Nikola Hristov, Ljubica Georgievska-Ismail, Tanja Anguseva, Zan Mitrev
BACKGROUND: Percutaneous transcatheter closure (PTC) of patent foramen ovale (PFO) is implicated in cryptogenic stroke, transitional ischemic attack (TIA) and treatment of a migraine. AIM: Our goal was to present our experience in the interventional treatment of PFO, as well as to evaluate the short and mid-term results in patients with closed PFO. MATERIAL AND METHODS: Transcatheter closure of PFO was performed in 52 patients (67.3% women, mean age 40...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28024853/inferior-vena-cava-compression-as-a-novel-maneuver-to-detect-patent-foramen-ovale-a%C3%A2-transesophageal-echocardiographic-study
#13
Eiji Yamashita, Tomoyuki Murata, Eri Goto, Takeshi Fujiwara, Takehito Sasaki, Kentaro Minami, Kohki Nakamura, Koji Kumagai, Shigeto Naito, Kazuomi Kario, Shigeru Oshima
BACKGROUND: The Valsalva maneuver, the most sensitive test for patent foramen ovale (PFO) detection, is difficult during transesophageal echocardiography (TEE), especially after sedation. The aim of this study was to compare PFO detection effectiveness between inferior vena cava (IVC) compression and the Valsalva maneuver. METHODS: A total of 293 patients with paroxysmal atrial fibrillation undergoing TEE before initial atrial fibrillation ablation were prospectively enrolled...
December 23, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28024095/recent-development-of-transcatheter-closure-of-atrial-septal-defect-and-patent-foramen-ovale-with-occluders
#14
REVIEW
Baiyu Tang, Feng Su, Xiangke Sun, Qin Wu, Quansheng Xing, Suming Li
Atrial septal defect (ASD) and patent foramen ovale (PFO) are common clinical congenital heart defects. As an effective method for the treatment of ASD and PFO, transcatheter closure with occluders presents many advantages, including safety, ease of operation, minimal invasiveness, and reduced complications. This contribution reviews the various types of occluders currently used in clinical applications and under development, including non degradable occluders, partially degradable occluders, and totally degradable occluders...
December 26, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27993750/amplatzer-versus-figulla-occluder-for-transcatheter-patent-foramen-ovale-closure
#15
Daniela Trabattoni, Achille Gaspardone, Gregory A Sgueglia, Franco Fabbiocchi, Gaetano Gioffrè, Piero Montorsi, Giuseppe Calligaris, Maria Iamele, Antonella De Santis, Antonio L Bartorelli
AIMS: To compare in a observational study acute and 12-month results of percutaneous closure of patent foramen ovale (PFO) with two occluder devices. METHODS AND RESULTS: Between June 2007 and October 2014, 406 consecutive patients (48.1±13.3 years, 243 women) underwent percutaneous PFO closure either with the Amplatzer (n=179) or the Figulla (n=227) device after a stroke or a transient ischemic attack ascribed to the PFO. A right-to- left shunt grade >1 was previously detected in all patients and atrial septal aneurysm was present in 111 (27...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27980121/chimeric-approach-for-narrowing-a-membrane-inserting-region-within-human-perforin
#16
Amy E Neely, Kimberly A Mandigo, Rebekah L Robinson, Traci L Ness, Mitch H Weiland
Perforin is a pore-forming, immune protein that functions to deliver an apoptotic cocktail of proteins into a target pathogen. Recent studies of the bacterial cholesterol-dependent cytolysins (CDCs) have provided a model for perforin's pore-forming mechanism. Both perforin and CDC family members share a conserved β-sheet flanked by two clusters of α-helices. Within the CDCs, these helices refold into two transmembrane β-hairpins, TMH1 and TMH2. Based upon structural conservation and electron microscopy imaging, the analogous helices within perforin are predicted to also be membrane inserting; however, these regions are approximately twice the length of the CDC TMHs...
December 15, 2016: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/27970217/tct-826-prospective-single-center-first-in-human-fih-clinical-trial-to-evaluate-the-safety-and-effectiveness-of-a-septal-occluder-with-bioresorbable-framework-in-patients-with-clinically-significant-atrial-septum-defect-asd-or-patent-foramen-ovale-pfo
#17
Björn Söderberg, Laura Vaskelyte, Sameer Gafoor, Ilona Hofmann, Andreas Mellmann, Jerome Bernhard, Horst Sievert
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969634/tct-28-occlutech-percutaneous-pfo-closure-safety-and-efficacy-registry-oppose
#18
David Hildick-Smith, Philip Maccarthy, Michael Mullen, Lindsay Morrison, Christopher Duke, Mark Spence
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27966903/critical-role-of-the-sorting-polymer-in-carbon-nanotube-based-minority-carrier-devices
#19
Arun T Mallajosyula, Wanyi Nie, Gautam Gupta, Jeffrey L Blackburn, Stephen K Doorn, Aditya D Mohite
A prerequisite for carbon nanotube-based optoelectronic devices is the ability to sort them into a pure semiconductor phase. One of the most common sorting routes is enabled through using specific wrapping polymers. Here we show that subtle changes in the polymer structure can have a dramatic influence on the figures of merit of a carbon nanotube-based photovoltaic device. By comparing two commonly used polyfluorenes (PFO and PFO-BPy) for wrapping (7,5) and (6,5) chirality SWCNTs, we demonstrate that they have contrasting effects on the device efficiency...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27966652/effectiveness-and-safety-of-transcatheter-patent-foramen-ovale-closure-for-migraine-eastform-trial
#20
Ying-Qi Xing, Yu-Zhu Guo, Yong-Sheng Gao, Zhen-Ni Guo, Peng-Peng Niu, Yi Yang
We evaluated the safety and effectiveness of transcatheter patent foramen ovale (PFO) closure for the treatment of migraine in a Chinese population. This non-randomized clinical trial enrolled 258 consecutive substantial or severe migraineurs with a right-to-left shunt (RLS) (grade II-IV) and grouped subjects according to their election or refusal of PFO closure. Migraine was diagnosed according to the International Classification of Headache Disorders III-beta and evaluated using the Headache Impact Test-6 (HIT-6)...
December 14, 2016: Scientific Reports
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