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https://www.readbyqxmd.com/read/29228110/autocorrelation-structure-in-the-macaque-dorsolateral-but-not-orbital-or-polar-prefrontal-cortex-predicts-response-coding-strength-in-a-visually-cued-strategy-task
#1
Valeria Fascianelli, Satoshi Tsujimoto, Encarni Marcos, Aldo Genovesio
In previous work, we studied the activity of neurons in the dorsolateral (PFdl), orbital (PFo), and polar (PFp) prefrontal cortex while monkeys performed a strategy task with 2 spatial goals. A cue instructed 1 of 2 strategies in each trial: stay with the previous goal or shift to the alternative goal. Each trial started with a fixation period, followed by a cue. Subsequently, a delay period was followed by a "go" signal that instructed the monkeys to choose one goal. After each choice, feedback was provided...
December 8, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29227129/assessment-of-a-portable-lactate-meter-for-field-use-in-the-white-rhinoceros-i-ceratotherium-simum-i
#2
Georgina C Cole, Adrian S W Tordiffe, Gerhard Steenkamp
Blood lactate is a predictor of mortality in critically ill humans and animals. Handheld lactate meters have the potential to be used in the field to evaluate the condition of severely injured rhinoceroses but have not been compared with laboratory-based methods. Agreement between a handheld lactate meter and a laboratory method was assessed, as was the stability of rhino blood lactate in the anticoagulant sodium fluoride/potassium oxalate (fluoride/oxalate). Blood samples were obtained from 53 white rhinos that had been immobilised for management reasons...
November 10, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/29225842/how-often-is-patent-foramen-ovale-an-innocent-bystander
#3
Francesco Versaci, Giampiero Vizzari, Domenico Sergi, Giuseppe Andò, Antonio Trivisonno, Francesco Romeo
Patent foramen ovale (PFO) is a risk factor for cryptogenetic stroke; its closure should be considered in selected patients. It is not always clear whether symptoms (presyncope, paresthesia) apparently due to paradoxical embolism are related with other cardiovascular disorders such as arrhythmias. Flecainide administration for post-PFO-closure supraventricular arrhythmias can unmask a latent undiagnosed Brugada syndrome.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29219954/migraine-with-aura-and-persistent-foramen-ovale
#4
P T Wilmshurst
The association between migraine with aura and persistent foramen ovale (PFO), as well as other right-to-left shunts, is described. A hypothesis that might explain this association is discussed. Observational studies suggested that when a PFO is closed patients who have migraine with aura are usually improved. The Migraine Intervention with STARFlex Technology (MIST) Trial was a randomised double-blind trial in patients with severe intractable migraine with aura and a moderate-large PFO that compared implantation of STARFlex devices with the intention of closing their PFO versus a sham procedure...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29217649/an-unusual-cause-of-hypoxia-getting-to-the-heart-of-the-matter
#5
Daniel Hammersley, Aamire Shamsi, Mohammad Murtaza Zaman, Phillip Berry, Lydia Sturridge
A 63 year old female presented to hospital with progressive exertional dyspnoea over a 6 month period. In the year preceding her admission, she reported an intercurrent history of abdominal pain, diarrhoea and weight loss. She was found to be hypoxic, the cause for which was initially unclear. A ventilation-perfusion scan identified a right-to-left shunt. Transoesophageal echocardiography (TOE) demonstrated a significant right-to-left intracardiac shunt through a patent foramen ovale (PFO); additionally severe tricuspid regurgitation was noted through a highly abnormal tricuspid valve...
December 7, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/29217343/patent-foramen-ovale-in-patients-with-pulmonary-embolism-a-prognostic-factor-on-ct-pulmonary-angiography
#6
Meng Zhang, Stephanie Tan, Vishal Patel, Benjamin A Zalta, Anna Shmukler, Jeffrey M Levsky, Vineet R Jain, Nada M Shaban, Linda B Haramati
BACKGROUND: Patent foramen ovale (PFO) in patients with acute pulmonary embolism (PE) represents a risk factor for mortality, but this has not been evaluated for CT pulmonary angiography (CTPA). The purpose of the present study was to assess the relationship between PFO and mortality in patients with acute PE diagnosed on CTPA. MATERIALS AND METHODS: This retrospective study included 268 adults [173 women, mean age 61 (range 22-98) years] diagnosed with acute PE on non-ECG-gated 64-slice CTPA in 2012 at our medical center...
December 2, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29210672/interfacial-engineering-with-ultrathin-poly-9-9-di-n-octylfluorenyl-2-7-diyl-pfo-layer-for-high-efficient-perovskite-light-emitting-diodes
#7
Qunliang Song, Chunyan Lin, Ping Chen, Ziyang Xiong, Debei Liu, Gang Wang, Yan Meng
Organic-inorganic hybrid perovskites have attracted great attentions in the field of lighting and display due to their very high color purity and low-cost solution-process. Researchers have done a lot of work in realizing high performance electroluminescent (EL) devices. However, the current efficiency of methyl-ammonium lead halide perovskite light-emitting diodes (PeLEDs) still needs to be improved. Herein, we demonstrates the enhanced performance of PeLEDs through introducing an ultrathin poly(9,9-di-n-octylfluorenyl-2,7-diyl) (PFO) buffer layer between poly(3,4-ethylendioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and CH3NH3PbBr3 perovskite...
December 6, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29191326/pfo-and-migraine-the-blind-leading-the-blinded
#8
EDITORIAL
Brian Whisenant, Mark Reisman
No abstract text is available yet for this article.
December 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29191325/percutaneous-closure-of-patent-foramen-ovale-in-patients-with-migraine-the-premium-trial
#9
RANDOMIZED CONTROLLED TRIAL
Jonathan M Tobis, Andrew Charles, Stephen D Silberstein, Sherman Sorensen, Brijeshwar Maini, Phillip A Horwitz, John C Gurley
BACKGROUND: Migraine is a prevalent and disabling disorder. Patent foramen ovale (PFO) has been associated with migraine, but its role in the disorder remains poorly understood. OBJECTIVES: This study examined the efficacy of percutaneous PFO closure as a therapy for migraine with or without aura. METHODS: The PREMIUM (Prospective, Randomized Investigation to Evaluate Incidence of Headache Reduction in Subjects With Migraine and PFO Using the AMPLATZER PFO Occluder to Medical Management) was a double-blind study investigating migraine characteristics over 1 year in subjects randomized to medical therapy with a sham procedure (right heart catheterization) versus medical therapy and PFO closure with the Amplatzer PFO Occluder device (St...
December 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29179276/-analysis-of-contrast-echocardiography-for-detecting-right-to-left-shunt-in-adults-with-patent-foramen-ovale
#10
X J Kong, Q F Chai, K Guo, Y F Zhao, Y H Wang
Objective: To analyze the contrast echocardiography for detecting right to left shunt in adults with patent foramen ovale(PFO), and study the relationship between PFO and cryptogenic stroke. Methods: Clinical data of forty-six adults patients with PFO diagnosed by transesophageal echocardiography(TEE)from March, 2012 to March, 2017 were retrospectively collected, and the patients were divided to 3 groups according to the direction and brightness of the color Doppler shunts: obvious left-to-right shunt (OLRS, group A), weak left-to-right shunt(WLRS, group B), bi-directional shunt(BDS, group C)...
November 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29173609/effects-of-patent-foramen-ovale-closure-on-obstructive-sleep-apnea-syndrome-pcosa-study
#11
Stephen P Hoole, Jules Hernández-Sánchez, William R Davies, Duncan C McNab, Patrick A Calvert, Bushra S Rana, Leonard M Shapiro, Michael G Davies
BACKGROUND: Previous studies have shown a higher prevalence of patent foramen ovale (PFO) in patients with obstructive sleep apnea syndrome (OSAS). Right to left shunting through a PFO may be encouraged by the respiratory physiology of OSAS, contributing to the disease pathophysiology. We assessed whether PFO closure would improve respiratory polygraphy parameters compared with baseline measurements in patients with OSAS. METHODS: Twenty-six patients with newly diagnosed OSAS and a moderate-large PFO (prevalence, 18% of 143 patients screened) were referred for PFO closure...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29168745/interaction-of-cholesterol-with-perfringolysin-o-what-have-we-learned-from-functional-analysis
#12
Sergey N Savinov, Alejandro P Heuck
Cholesterol-dependent cytolysins (CDCs) constitute a family of pore-forming toxins secreted by Gram-positive bacteria. These toxins form transmembrane pores by inserting a large β-barrel into cholesterol-containing membranes. Cholesterol is absolutely required for pore-formation. For most CDCs, binding to cholesterol triggers conformational changes that lead to oligomerization and end in pore-formation. Perfringolysin O (PFO), secreted by Clostridium perfringens, is the prototype for the CDCs. The molecular mechanisms by which cholesterol regulates the cytolytic activity of the CDCs are not fully understood...
November 23, 2017: Toxins
https://www.readbyqxmd.com/read/29148245/a-brain-heart-team-approach-to-pfo
#13
Kirk N Garratt, Eric Horlick, Clifford Kavinsky, Kenneth Rosenfield
No abstract text is available yet for this article.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29131286/conscious-sedation-for-transcatheter-implantation-of-atrial-septal-occluders-with-the-2d-and-3d-transesophageal-echocardiography-guidance-the-feasibility-and-safety-study
#14
Piotr Lipiec, Dawid Miśkowiec, Jan Z Peruga, Michał Plewka, Ewa Szymczyk, Paulina Wejner-Mik, Karolina Kupczyńska, Jarosław D Kasprzak
BACKGROUND: General anesthesia may have negative impact on patients mortality and morbidity, as well as overall procedure costs in atrial septal occluders (ASO) implantation. AIM: We sought to evaluate the safety, efficacy and feasibility of conscious sedation for transcatheter implantation of ASO. METHODS: 122 patients (pts) referred for transcatheter implantation of ASO were included. Mean patients' age was 51±15 years, 43 patients were male (35%)...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29125001/hypoxia-due-to-positive-pressure-ventilation-in-edwards-syndrome-a-case-report
#15
Sun Kyung Hoon, Seung-Woo Kang, Sang-Hyun Kwak, Joungmin Kim
Edwards' syndrome also known as trisomy 18 is a congenital disorder associated with cardiovascular issues including ventricular septal defect (VSD), atrial septal defect (ASD) and patent duct arteriosus (PDA). An emergency colostomy was performed on a neonate born with an imperforate anus. Pre-operative transthoracic echocardiography showed presence of VSD, a patent foramen ovale (PFO) or ASD. Even though the baby had a good general condition and optimal peripheral oxygen saturation (SpO2), during positive pressure ventilation, she suffered severe hypoxia (50% SpO2)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29123934/symptomatic-patent-foramen-ovale-with-hemidiaphragm-paralysis
#16
Hussain Ibrahim, Adnan Khan, Shawn P Nishi, Ken Fujise, Syed Gilani
Dyspnea accounts for more than one-fourth of the hospital admissions from Emergency Department. Chronic conditions such as Chronic Obstructive Pulmonary Disease, Congestive Heart Failure, and Asthma are being common etiologies. Less common etiologies include conditions such as valvular heart disease, pulmonary embolism, and right-to-left shunt (RLS) from patent foramen ovale (PFO). PFO is present in estimated 20-30% of the population, mostly a benign condition. RLS via PFO usually occurs when right atrium pressure exceeds left atrium pressure...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29119650/thermally-activated-delayed-fluorescence-in-y3n-c80-endohedral-fullerene-time-resolved-luminescence-and-electron-paramagnetic-resonance-studies
#17
Michal Zalibera, Denis S Krylov, Dimitrios Karagiannis, Paul-Anton Will, Frank Ziegs, Sandra Schiemenz, Wolfgang Lubitz, Sebastian Reineke, Anton Savitsky, Alexey Alexandrovich Popov
Endohedral fullerene Y3N@C80 exhibits luminescence with reasonable quantum yield and extraordinary long lifetime. By variable-temperature steady-state and time-resolved luminescence spectroscopy, we demonstrate that above 60 K the Y3N@C80 exhibits thermally-activated delayed fluorescence with maximum emission at 120 K and a negligible prompt fluorescence. Below 60 K, a phosphorescence with a lifetime of 192 ms is observed. Spin distribution and dynamics in the triplet excited state is investigated with X- and W-band EPR and ENDOR spectroscopies and DFT computations...
November 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29100162/synthesis-and-application-of-a-new-carboxylated-cellulose-derivative-part-iii-removal-of-auramine-o-and-safranin-t-from-mono-and-bi-component-spiked-aqueous-solutions
#18
Filipe Simões Teodoro, Megg Madonyk Cota Elias, Gabriel Max Dias Ferreira, Oscar Fernando Herrera Adarme, Ranylson Marcello Leal Savedra, Melissa Fabíola Siqueira, Luis Henrique Mendes da Silva, Laurent Frédéric Gil, Leandro Vinícius Alves Gurgel
In the third part of this series of studies, the adsorption of the basic textile dyes auramine-O (AO) and safranin-T (ST) on a carboxylated cellulose derivative (CTA) were evaluated in mono- and bi-component spiked aqueous solutions. Adsorption studies were developed as a function of solution pH, contact time, and initial dye concentration. Adsorption kinetic data were modeled by monocomponent kinetic models of pseudo-first- (PFO), pseudo-second-order (PSO), intraparticle diffusion, and Boyd, while the competitive kinetic model of Corsel was used to model bicomponent kinetic data...
October 25, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29096902/-paradoxical-embolism-myth-or-reality
#19
P Aubry, H Demian, E Brochet, J-M Juliard
Paradoxical embolism should be suspected in front of a clinical phenomenon of thromboembolism associated with an anatomical right-to-left shunt. Others potential cardiac sources of thromboembolism must be ruled out. Strokes constitute the most frequent clinical manifestations of paradoxical embolism. Right-to-left left shunts are in connection with intracardiac defects (atrial septal defect and patent foramen ovale) or pulmonary arteriovenous malformations. The probability that a discovered PFO is stroke-related can be evaluated by a score...
December 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29090661/patent-foramen-ovale-closure-with-gore-helex-or-cardioform-septal-occluder-vs-antiplatelet-therapy-for-reduction-of-recurrent-stroke-or-new-brain-infarct-in-patients-with-prior-cryptogenic-stroke-design-of-the-randomized-gore-reduce-clinical-study
#20
Scott E Kasner, Lars Thomassen, Lars Søndergaard, John F Rhodes, Coby C Larsen, Joth Jacobson
Rationale The utility of patent foramen ovale (PFO) closure for secondary prevention in patients with prior cryptogenic stroke is uncertain despite multiple randomized trials completed to date. Aims The Gore REDUCE Clinical Study (REDUCE) aims to establish superiority of patent foramen ovale closure in conjunction with antiplatelet therapy over antiplatelet therapy alone in reducing the risk of recurrent clinical ischemic stroke or new silent brain infarct in patients who have had a cryptogenic stroke. Methods and design This controlled, open-label trial randomized 664 subjects with cryptogenic stroke at 63 multinational sites in a 2:1 ratio to either antiplatelet therapy plus patent foramen ovale closure (with GORE® HELEX® Septal Occluder or GORE® CARDIOFORM Septal Occluder) or antiplatelet therapy alone...
December 2017: International Journal of Stroke: Official Journal of the International Stroke Society
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