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https://www.readbyqxmd.com/read/27921028/two-year-results-after-convective-radiofrequency-water-vapor-thermal-therapy-of-symptomatic-benign-prostatic-hyperplasia
#1
Christopher M Dixon, Edwin Rijo Cedano, Dalibor Pacik, Vítězslav Vit, Gabriel Varga, Lennart Wagrell, Thayne R Larson, Lance A Mynderse
OBJECTIVE: The objective of this study was to assess the effectiveness and safety of convective radiofrequency (RF) water vapor thermal therapy in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH); a pilot study design with 2-year follow-up evaluations. PATIENTS AND METHODS: Men aged ≥45 years with an International Prostate Symptom Score ≥13, a maximum urinary flow rate (Qmax) ≤15 mL/s, and prostate volume 20-120 cc were enrolled in a prospective, open-label pilot study using convective RF water vapor energy with the Rezūm System...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27920821/protective-effect-of-vitamin-c-vitamin-b12-and-omega-3-on-lead-induced-memory-impairment-in-rat
#2
Saeedeh Alsadat Moosavirad, Mohammad Rabbani, Mohammad Sharifzadeh, Ali Hosseini-Sharifabad
Lead belongs to the heavy metal group and is considered as an environmental contaminant. Acute or chronic contact to lead can change the physiological function of human organs. One of the most important disorders following the lead exposure is neurotoxicity. Lead neurotoxicity consists of the neurobehavioral disturbances like cognitive impairment. The aim of the current study is to evaluate the possible protective effect of vitamin C (Vit C), vitamin B12 (Vit B12), omega 3 (ω-3), or their combination on the lead-induced memory disorder...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27916788/effects-of-dietary-oregano-essential-oil-and-vitamin-e-supplementation-on-meat-quality-stress-response-and-intestinal-morphology-in-pigs-following-transport-stress
#3
Yi Zou, Xiao Ming Hu, Ting Zhang, Hong Kui Wei, Yuan Fei Zhou, Zhong Xin Zhou, Jian Peng
This study investigates the effects of dietary oregano essential oil (OEO) and vitamin E (Vit E) supplementation on meat quality, stress response and intestinal morphology in pigs following transport stress. A total of 288 finishing pigs were randomly assigned to three groups: a basal diet or a basal diet supplemented either with 200 mg/kg Vit E or 25 mg/kg OEO. After a 28-day feeding trial, total of 132 finishing pigs according diet and transport stress were assigned to one of four treatment groups: 1) control treatment without transport stress (Control group), 2) control treatment with 5-hr transport stress (Negative group), 3) Vit E treatment with 5-hr transport stress and 4) OEO treatment with 5-hr transport stress...
December 2, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27916480/long-term-efficacy-and-safety-of-%C3%AE-1-proteinase-inhibitor-treatment-for-emphysema-caused-by-severe-%C3%AE-1-antitrypsin-deficiency-an-open-label-extension-trial-rapid-ole
#4
Noel G McElvaney, Jonathan Burdon, Mark Holmes, Allan Glanville, Peter A B Wark, Philip J Thompson, Paul Hernandez, Jan Chlumsky, Helmut Teschler, Joachim H Ficker, Niels Seersholm, Alan Altraja, Riitta Mäkitaro, Joanna Chorostowska-Wynimko, Marek Sanak, Paul I Stoicescu, Eeva Piitulainen, Oliver Vit, Marion Wencker, Michael A Tortorici, Michael Fries, Jonathan M Edelman, Kenneth R Chapman
BACKGROUND: Purified α1 proteinase inhibitor (A1PI) slowed emphysema progression in patients with severe α1 antitrypsin deficiency in a randomised controlled trial (RAPID-RCT), which was followed by an open-label extension trial (RAPID-OLE). The aim was to investigate the prolonged treatment effect of A1PI on the progression of emphysema as assessed by the loss of lung density in relation to RAPID-RCT. METHODS: Patients who had received either A1PI treatment (Zemaira or Respreeza; early-start group) or placebo (delayed-start group) in the RAPID-RCT trial were included in this 2-year open-label extension trial (RAPID-OLE)...
December 1, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27915990/possible-molecular-mechanisms-by-which-vitamin-d-prevents-inflammatory-bowel-disease-and-colitis-associated-colorectal-cancer
#5
Zijian Luan, Yiming Ma, Yu Xin, Jiaming Qian, Hongying Wang
It is well accepted that inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is one of high risk factors for colorectal cancer (CRC). This supports the notion that inflammation plays a key role in cancer development. Epidemiologic studies have shown that vitamin D (Vit D) deficiency is associated with IBD and various types of cancer including colorectal cancer. Clinical trials and mouse models have shown that Vit D is beneficial in preventing or ameliorating inflammation and carcinogenesis...
December 2, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27914814/rush-venom-immunotherapy-in-children
#6
Ronit Confino-Cohen, Yossi Rosman, Arnon Goldberg
BACKGROUND: Rush venom immunotherapy (VIT) is highly effective in Hymenoptera venom allergy. Still, specific data regarding its safety and efficiency in children are rather sparse. OBJECTIVES: The objective of this study was to better evaluate the safety and efficiency of rush VIT in this specific age group. METHODS: Children younger than 16 years with systemic reaction to insect sting involving, at least, one body system other than skin and children aged 16-18 years with any kind of systemic reaction were offered conventional or rush VIT with a build-up phase that lasted 3 days...
November 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#7
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette D LaMarca
Autoantibodies to the angiotensin II (ANGII) type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that Vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined if the decrease in AT1-AA was the mechanism whereby Vitamin D lowered MAP or if it was through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1 and sFlt-1 are increased with AT1-AA induced hypertension and considered markers of PE in pregnant women...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27894899/dietary-flax-seed-oil-and-or-vitamin-e-improve-sperm-parameters-of-cloned-goats-following-freezing-thawing
#8
Rohollah Kargar, Mohsen Forouzanfar, Gholamreza Ghalamkari, Mohammad Hossein Nasr Esfahani
Semen cryopreservation is affected by individual differences and use of clones animal from the same source is the main tool to eliminate genetic variation. Among many nutrients that are necessary for fertility, essential fatty acids and antioxidants are vital for production of healthy sperm by improving sperm membrane integrity and protecting sperm from oxidative stress. The goal of the current study was to investigate whether a flax seed oil or/and Vitamin E dietary supplementation could improve semen quality of cloned bucks following semen cryopreservation...
November 25, 2016: Cryobiology
https://www.readbyqxmd.com/read/27885726/cryopreservation-of-feline-oocytes-by-vitrification-using-commercial-kits-and-slush-nitrogen-technique
#9
L Fernandez-Gonzalez, K Jewgenow
Assisted reproductive techniques are a valuable tool for conservation breeding of endangered species. Cryopreservation methods are the basis of gamete banks, supporting genetic diversity preservation. Unfortunately, cryopreservation of feline oocytes is still considered an experimental technique. The aim of this study was to compare two commercial kits, with our protocol for vitrification of cat oocytes (IZW), which comprises a three-step method with ethylene glycol, DMSO, fetal calf serum, trehalose and Ficoll PM-70...
November 24, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27871484/identification-of-a-nuclear-exosome-decay-pathway-for-processed-transcripts
#10
Nicola Meola, Michal Domanski, Evdoxia Karadoulama, Yun Chen, Coline Gentil, Dennis Pultz, Kristoffer Vitting-Seerup, Søren Lykke-Andersen, Jens S Andersen, Albin Sandelin, Torben Heick Jensen
The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein adaptors. One example is the trimeric human nuclear exosome targeting (NEXT) complex, which is composed of hMTR4, the Zn-finger protein ZCCHC8, and the RNA-binding factor RBM7. NEXT primarily targets early and unprocessed transcripts, which demands a rationale for how the nuclear exosome recognizes processed RNAs. Here, we describe the poly(A) tail exosome targeting (PAXT) connection, which comprises the ZFC3H1 Zn-knuckle protein as a central link between hMTR4 and the nuclear poly(A)-binding protein PABPN1...
November 3, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27866319/successful-posaconazole-therapy-of-disseminated-alternariosis-due-to-alternaria-infectoria-in-a-heart-transplant-recipient
#11
Pavlina Lyskova, Milos Kubanek, Vit Hubka, Eva Sticova, Ludek Voska, Dana Kautznerova, Miroslav Kolarik, Petr Hamal, Martina Vasakova
We report a case of phaeohyphomycosis caused by Alternaria infectoria in a 61-year-old heart transplant recipient with multiple skin lesions and pulmonary infiltrates. The infection spread via the haematogenous route from the primary cutaneous lesions into the lungs. The diagnosis was based on the histopathological examination, direct microscopy, skin lesion cultures and detection of Alternaria DNA in the bronchoalveolar lavage fluid using molecular methods. The treatment consisted of a combination of surgical excision and systemic antifungal therapy...
November 19, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27863277/vitamin-d-supplementation-affects-the-igf-system-in-men-after-acute-exercise
#12
Rachel L Darr, Kathleen J Savage, Mark Baker, Gregory E Wilding, Amy Raswalsky, Todd Rideout, Richard W Browne, Peter J Horvath
OBJECTIVE: Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system. DESIGN: D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit...
November 5, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27849514/first-record-of-phlebotomus-transphlebotomus-mascittii-in-slovakia
#13
Vit Dvorak, Kristyna Hlavackova, Alica Kocisova, Petr Volf
A large-scale entomological survey was carried out in summer 2016 in the Czech Republic and Slovakia. It revealed, for the first time, the presence of the phlebotomine sand fly Phlebotomus (Transphlebotomus) mascittii Grassi, 1908 (Diptera: Phlebotominae) in south-western Slovakia. Species identification of a captured female was confirmed by both morphological and sequencing (COI) analyses.
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/27847277/influence-of-surfactants-on-depsipeptide-submicron-particle-formation
#14
Nadia Brunacci, Christian Wischke, Toufik Naolou, Axel T Neffe, Andreas Lendlein
Surfactants are required for the formation and stabilization of hydrophobic polymeric particles in aqueous environment. In order to form submicron particles of varying sizes from oligo[3-(S)-sec-butylmorpholine-2,5-dione]diols ((OBMD)-diol), different surfactants were investigated. As new surfactants, four-armed star-shaped oligo(ethylene glycol)s of molecular weights of 5-20kDa functionalized with desamino-tyrosine (sOEG-DAT) resulted in smaller particles with lower PDI than with desaminotyrosyl tyrosine (sOEG-DATT) in an emulsion/solvent evaporation method...
November 12, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27846770/the-relationship-between-balance-and-vitamin-25-oh-d-in-fibromyalgia-patients
#15
Meliha Kasapoğlu Aksoy, Lale Altan, Burcu Ökmen Metin
: INTRODUCTİON: Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to the impact of vitamin D on postural control. The aim of the current study was to investigate the relationship between vitamin 25(OH)D levels and pain, balance and daily activities in patients with FMS...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846230/influence-of-elevation-data-resolution-on-spatial-prediction-of-colluvial-soils-in-a-luvisol-region
#16
Vít Penížek, Tereza Zádorová, Radka Kodešová, Aleš Vaněk
The development of a soil cover is a dynamic process. Soil cover can be altered within a few decades, which requires updating of the legacy soil maps. Soil erosion is one of the most important processes quickly altering soil cover on agriculture land. Colluvial soils develop in concave parts of the landscape as a consequence of sedimentation of eroded material. Colluvial soils are recognised as important soil units because they are a vast sink of soil organic carbon. Terrain derivatives became an important tool in digital soil mapping and are among the most popular auxiliary data used for quantitative spatial prediction...
2016: PloS One
https://www.readbyqxmd.com/read/27845950/carbon-dioxide-insufflation-during-colonoscopy-in-inflammatory-bowel-disease-patients-a-double-blind-randomized-single-center-trial
#17
Přemysl Falt, Vít Šmajstrla, Petr Fojtík, Martin Hill, Ondřej Urban
OBJECTIVE: Bowel distension by insufflated air causes abdominal discomfort after colonoscopy. Carbon dioxide (CO2) instead of air insufflation during colonoscopy can reduce postprocedural discomfort in diagnostic and screening cases. Discomfort after colonoscopy and CO2 insufflation have never been studied in inflammatory bowel disease (IBD) patients, characterized by younger age, structural changes of the colon, and need for repeated and frequently uncomfortable colonoscopies. Our trial was designed to evaluate postprocedural discomfort associated with CO2 compared with air insufflation in unsedated or minimally sedated patients with known IBD...
November 11, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27827897/comparative-analysis-of-toxic-responses-of-organic-extracts-from-diesel-and-selected-alternative-fuels-engine-emissions-in-human-lung-beas-2b-cells
#18
Helena Libalova, Pavel Rossner, Kristyna Vrbova, Tana Brzicova, Jitka Sikorova, Michal Vojtisek-Lom, Vit Beranek, Jiri Klema, Miroslav Ciganek, Jiri Neca, Katerina Pencikova, Miroslav Machala, Jan Topinka
This study used toxicogenomics to identify the complex biological response of human lung BEAS-2B cells treated with organic components of particulate matter in the exhaust of a diesel engine. First, we characterized particles from standard diesel (B0), biodiesel (methylesters of rapeseed oil) in its neat form (B100) and 30% by volume blend with diesel fuel (B30), and neat hydrotreated vegetable oil (NEXBTL100). The concentration of polycyclic aromatic hydrocarbons (PAHs) and their derivatives in organic extracts was the lowest for NEXBTL100 and higher for biodiesel...
November 3, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27824899/sarcosine-up-regulates-expression-of-genes-involved-in-cell-cycle-progression-of-metastatic-models-of-prostate-cancer
#19
Zbynek Heger, Miguel Angel Merlos Rodrigo, Petr Michalek, Hana Polanska, Michal Masarik, Vitezslav Vit, Mariana Plevova, Dalibor Pacik, Tomas Eckschlager, Marie Stiborova, Vojtech Adam
The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent LNCaP) with sarcosine stimulates cells proliferation in vitro. Similar stimulatory effects were observed also in PCa murine xenografts, in which sarcosine treatment induced a tumor growth and significantly reduced weight of treated mice (p < 0.05). Determination of sarcosine metabolism-related amino acids and enzymes within tumor mass revealed significantly increased glycine, serine and sarcosine concentrations after treatment accompanied with the increased amount of sarcosine dehydrogenase...
2016: PloS One
https://www.readbyqxmd.com/read/27801843/comparative-transcriptomic-analysis-of-grape-berry-in-response-to-root-restriction-during-developmental-stages
#20
Feng Leng, Qiong Lin, Di Wu, Shiping Wang, Dengliang Wang, Chongde Sun
Root restriction improved berry quality by being involved in diverse aspects of grapevine life. However, the molecular mechanism driving this process is not understood very well. In this study, the 'Summer Black' grape berry (Vitis vinifera × V. labrusca) under root restriction was investigated, which showed an increase of total soluble solids (TSS), color index of red grapes (CIRG) value, anthocyanins accumulation, total phenolics and total procyanidins contents during berry development compared with those in control berries...
October 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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