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https://www.readbyqxmd.com/read/28748602/vincristine-irinotecan-and-temozolomide-in-children-and-adolescents-with-relapsed-rhabdomyosarcoma
#1
Bhuvana A Setty, Joseph R Stanek, Leo Mascarenhas, Alexandra Miller, Rochelle Bagatell, Fatih Okcu, Lauren Nicholls, David Lysecki, Abha A Gupta
BACKGROUND: The combination of vincristine, irinotecan, and temozolomide (VIT) is often used to treat children and adolescents with relapsed rhabdomyosarcoma (RMS); however, the outcome of these patients has not been previously described. PROCEDURES: We sought to determine the response rate (RR) and progression-free survival (PFS) for patients with relapsed RMS treated with VIT by retrospective review of patients treated at five tertiary care hospitals. Prior treatment with irinotecan was permitted...
July 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28737734/storage-of-fruits-and-vegetables-in-refrigerator-increases-their-phenolic-acids-but-decreases-the-total-phenolics-anthocyanins-and-vitamin-c-with-subsequent-loss-of-their-antioxidant-capacity
#2
Joseph H Y Galani, Jalpesh S Patel, Nilesh J Patel, Jayant G Talati
It is of paramount importance for consumers, scientists and industrialists to understand how low-temperature storage of food items affects their bioactive compounds and properties. This study evaluated the effects of cold storage on total phenolics (TP), phenolic acids profile (PA), total anthocyanins (TA), total ascorbic acid (Vit. C) and antioxidant activity (AA) of 19 fruits and vegetables, collected from local Indian markets and stored in refrigerator (4 °C) during 15 days. Content of TP was highest in dill and amaranth and decreased (up to 29...
July 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28734827/multi-omics-analyses-of-starvation-responses-reveal-a-central-role-for-lipoprotein-metabolism-in-acute-starvation-survival-in-c-%C3%A2-elegans
#3
Eva Bang Harvald, Richard R Sprenger, Kathrine Brændgaard Dall, Christer S Ejsing, Ronni Nielsen, Susanne Mandrup, Alejandro Brenes Murillo, Mark Larance, Anton Gartner, Angus I Lamond, Nils J Færgeman
Starvation causes comprehensive metabolic changes, which are still not fully understood. Here, we used quantitative proteomics and RNA sequencing to examine the temporal starvation responses in wild-type Caenorhabditis elegans and animals lacking the transcription factor HLH-30. Our findings show that starvation alters the abundance of hundreds of proteins and mRNAs in a temporal manner, many of which are involved in central metabolic pathways, including lipoprotein metabolism. We demonstrate that premature death of hlh-30 animals under starvation can be prevented by knockdown of either vit-1 or vit-5, encoding two different lipoproteins...
July 12, 2017: Cell Systems
https://www.readbyqxmd.com/read/28732511/primary-liver-transplantation-and-liver-retransplantation-comparison-of-health-related-quality-of-life-and-mental-status-a-cross-sectional-study
#4
Johannes Broschewitz, Georg Wiltberger, Nicco Krezdorn, Felix Krenzien, Julia Förster, Georgi Atanasov, Hans-Michael Hau, Moritz Schmelzle, Andreas Hinz, Michael Bartels, Christian Benzing
BACKGROUND: Liver Retransplantation (Re-LT) procedures are associated with an increased risk of morbidity and mortality. Up to date, there is no knowledge on the health-related quality of life and the mental status of these patients. METHODS: Health-Related Quality of Life (HRQoL) was assessed by using the Short Form 36 (SF-36) Health Survey and Mental Status was assessed by using the Hospital Anxiety and Depression Scale (HADS). The patients were examined in different assessments: During regular check-up examinations in the LT outpatient department in 2011 (Survey 1) and in a postal survey in 2013 (Survey 2)...
July 21, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28710069/vitamin-c-mitigates-oxidative-nitrosative-stress-and-inflammation-in-doxorubicin-induced-cardiomyopathy
#5
Gauri Akolkar, Danielle da Silva Dias, Prathapan Ayyappan, Ashim K Bagchi, Davinder S Jassal, Vera Mc Salemi, Maria Claudia Irigoyen, Katia De Angelis, Pawan K Singal
Increase in oxidative/nitrosative stress is one of the mechanisms associated with the development of cardiotoxicity due to Doxorubicin (Dox), a potent chemotherapy drug. Previously, we reported mitigation of Dox-induced oxidative/nitrosative stress and apoptosis by Vitamin C (Vit C) in isolated cardiomyocytes. In the present in vivo study in rats, we investigated the effect of prophylactic treatment with Vit C on Dox-induced apoptosis, inflammation, oxidative/nitrosative stress, cardiac dysfunction and Vit C transporter proteins...
July 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28706538/safety-of-100%C3%A2-%C3%A2%C2%B5g-venom-immunotherapy-rush-protocols-in-children-compared-to-adults
#6
Johanna Stoevesandt, Christine Hosp, Andreas Kerstan, Axel Trautmann
BACKGROUND: There is a paucity of studies examining the safety of venom immunotherapy (VIT) in children. We aimed to assess the incidence of anaphylactic side effects during rush VIT in a cohort of pediatric patients and adult controls. METHODS: 72 consecutive cycles of VIT-buildup in 71 children/adolescents aged 7-17 years were retrospectively evaluated and compared to an adult control group (n = 981) with regard to baseline parameters (sex, causative venom, severity of index sting reaction, results of allergy testing, comorbidities) and the incidence of anaphylactic adverse reactions...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28702769/short-and-long-term-outcomes-after-combined-intravenous-thrombolysis-and-mechanical-thrombectomy-versus-direct-mechanical-thrombectomy-a-prospective-single-center-study
#7
Giovanni Merlino, Massimo Sponza, Benedetto Petralia, Alessandro Vit, Vladimir Gavrilovic, Andrea Pellegrin, Michele Rana, Iacopo Cancelli, Sara Naliato, Simone Lorenzut, Roberto Marinig, Ferdinando Calzolari, Roberto Eleopra
Recent clinical trials demonstrated that mechanical thrombectomy (MT) using second-generation endovascular devices has beneficial effects in acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, it remains controversial if intravenous thrombolysis (IVT) prior to MT is superior compared to direct mechanical thrombectomy (DMT). The aims of this study were to compare short and long-term outcomes between IVT + MT and DMT patients. We prospectively recruited AIS patients with LVO in the anterior or posterior circulation eligible for MT with and without prior IVT...
August 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28699324/corneal-endothelial-cell-loss-and-corneal-biomechanical-characteristics-after-two-step-sequential-or-combined-phaco-vitrectomy-surgery-for-idiopathic-epiretinal-membrane
#8
Hassan Hamoudi, Ulrik Correll Christensen, Morten La Cour
PURPOSE: To assess the impact of sequential and combined surgery [cataract surgery and 23-gauge pars plana vitrectomy (PPV) with peeling] on corneal endothelium cell density (CED) and corneal biomechanical characteristics. METHODS: Phakic eyes with epiretinal membrane (ERM) were prospectively allocated to (i) cataract surgery and subsequent PPV (CAT group), (ii) PPV and subsequent cataract surgery (VIT group) or (iii) phacovitrectomy (COMBI group). Eyes were examined at baseline, 1 month after each surgery, and at 3 and 12 months follow-up...
August 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28698476/acute-supplementation-with-high-dose-vitamin-d3-increases-serum-anti-m%C3%A3-llerian-hormone-in-young-women
#9
Nicola A Dennis, Lisa A Houghton, Michael W Pankhurst, Michelle J Harper, Ian S McLennan
Anti-Müllerian hormone (AMH) is a paracrine regulator of ovarian follicles. Vitamin D (Vit D) regulates AMH production in vitro, but its role as a regulator of ovarian AMH production is contentious. If Vit D influences ovarian AMH production, then an acute rise in Vit D level should lead to an acute rise in circulating AMH levels. This hypothesis was tested with a randomized double-blind design, with 18-25-year-old women recruited from the community. The study was conducted in early spring, when the marker of Vit D level (25-hydroxyvitamin D, 25(OH)D) tends to be at its nadir...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28687854/neuroprotective-effects-of-vitamin-d-alone-or-in-combination-with-lamotrigine-against-lithium-pilocarpine-model-of-status-epilepticus-in-rats
#10
Amal M Mahfoz, Ali F Abdel-Wahab, Mohamed A Afify, Naiyer Shahzad, Ibrahim A A Ibrahim, Naser A ElSawy, Ghazi A Bamagous, Saeed S Al Ghamdi
Status epilepticus (SE) is considered one of the major serious forms of epilepsy with high mortality rate. Since the currently available antiepileptic drugs have low efficacy and high adverse effects, new more efficient and safe therapies are critically needed. There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Recent studies have shown significant prophylactic and therapeutic potential of vitamin D (vit-D) use in many neurological disorders...
July 7, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28687456/increased-oxidative-stress-and-deficient-antioxidant-levels-may-be-involved-in-the-pathogenesis-of-idiopathic-recurrent-acute-pancreatitis
#11
Sawan Bopanna, Baibaswat Nayak, Shyam Prakash, Shalimar, Soumya Jagannath Mahapatra, Pramod Kumar Garg
BACKGROUND: Increased Oxidative Stress (OS) is implicated in the pathogenesis of Chronic Pancreatitis (CP). Whether or not OS contributes to disease progression through the stages of Recurrent Acute Pancreatitis(RAP), to CP is not known. Increased OS, if present in RAP could be an important therapeutic target in preventing progression of RAP to CP. OBJECTIVE: To assess the oxidative stress and antioxidant status in patients with idiopathic RAP. METHODS: 50 consecutive patients with Idiopathic Recurrent Acute Pancreatitis (IRAP) were included...
June 20, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28686638/which-immunotherapy-product-is-better-for-patients-allergic-to-polistes-venom-a-laboratory-and-clinical-study
#12
Eleonora Savi, Cristoforo Incorvaia, Elisa Boni, Marina Mauro, Silvia Peveri, Valerio Pravettoni, Oliviero Quercia, Federico Reccardini, Marcello Montagni, Laura Pessina, Erminia Ridolo
BACKGROUND: Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. it has been proposed that only the European species P. dominulus should be used for VIT. However, this recommendation is not present in any international guideline...
2017: PloS One
https://www.readbyqxmd.com/read/28684912/the-effects-of-grafted-mesenchymal-stem-cells-labeled-with-iron-oxide-or-cobalt-zinc-iron-nanoparticles-on-the-biological-macromolecules-of-rat-brain-tissue-extracts
#13
Bozena Novotna, Vit Herynek, Pavel Rossner, Karolina Turnovcova, Pavla Jendelova
INTRODUCTION: Rat mesenchymal stem cells (rMSCs) labeled with 1) poly-l-lysine-coated superparamagnetic iron oxide nanoparticles or 2) silica-coated cobalt-zinc-iron nanoparticles were implanted into the left brain hemisphere of rats, to assess their effects on the levels of oxidative damage to biological macromolecules in brain tissue. METHODS: Controls were implanted with unlabeled rMSCs. Animals were sacrificed 24 hours or 4 weeks after the treatment, and the implantation site along with the surrounding tissue was isolated from the brain...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28684433/vacuolar-iron-transporter-tavit2-transports-fe-and-mn-and-is-effective-for-biofortification
#14
James M Connorton, Eleanor R Jones, Ildefonso Rodriguez-Ramiro, Susan Fairweather-Tait, Cristobal Uauy, Janneke Balk
Increasing the intrinsic nutritional quality of crops, known as biofortification, is viewed as a sustainable approach to alleviate micronutrient deficiencies. In particular iron deficiency anaemia is a major global health issue, but the iron content of staple crops such as wheat is difficult to change because of genetic complexity and homeostasis mechanisms. To identify target genes for biofortification of wheat (Triticum aestivum), we functionally characterized homologs of the Vacuolar Iron Transporter (VIT)...
July 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28683192/evaluation-of-the-possible-nephroprotective-effects-of-vitamin-e-and-rosuvastatin-in-amikacin-induced-renal-injury-in-rats
#15
Ahmed Selim, Marwa M Khalaf, Amany M Gad, Ola M Abd El-Raouf
Amikacin (AMIK) is an aminoglycoside antibiotic that possesses considerable nephrotoxic adverse effects. This study examined the protective effects of vitamin E (VIT. E) or rosuvastatin (ROSU) against AMIK-induced nephrotoxicity. For this purpose, eight groups of rats were used. Two control groups received saline and vehicle, AMIK group (1.2 g/kg, i.p.), VIT. E group (1000 mg/kg; p.o.), ROSU group (10 mg/kg; p.o.), AMIK + VIT. E group, AMIK + ROSU group, and combination group. The results showed that AMIK significantly increased serum levels of urea and creatinine...
July 6, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28681469/differential-expression-of-homologous-recombination-dna-repair-genes-in-the-early-and-advanced-stages-of-myelodysplastic-syndrome
#16
Jan Valka, Jitka Vesela, Hana Votavova, Michaela Dostalova-Merkerova, Zuzana Horakova, Vit Campr, Jana Brezinova, Zuzana Zemanova, Anna Jonasova, Jaroslav Cermak, Monika Belickova
BACKGROUND: The high incidence of mutations and cytogenetic abnormalities in patients with myelodysplastic syndrome (MDS) suggests that defects in DNA repair mechanisms. We monitored DNA repair pathways in MDS and their alterations during disease progression. METHODS: Expression profiling of DNA repair genes was performed on CD34+ cells and paired samples were used for monitoring of RAD51 and XRCC2 gene expression during disease progression. Immunohistochemical staining for RAD51 was done on histology samples...
July 5, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28678856/time-course-of-changes-in-oxidative-stress-and-stress-induced-proteins-in-cardiomyocytes-exposed-to-doxorubicin-and-prevention-by-vitamin-c
#17
Ana Ludke, Gauri Akolkar, Prathapan Ayyappan, Anita K Sharma, Pawan K Singal
We previously reported that Vitamin C (Vit C) protects against doxorubicin (Dox)-induced cardiotoxicity by reducing oxidative stress, p38 mitogen-activated kinase (MAPK) and p53 activation and rescuing cell death in isolated adult cardiomyocytes. The pattern of activation and the role of oxidative stress as well as down-stream mechanisms for such protection remain elusive. Therefore the present study aims to analyze time-dependant generation of reactive oxygen species (ROS) and the activation of stress induced signalling pathways in cardiomyocytes treated with Dox and Vit C...
2017: PloS One
https://www.readbyqxmd.com/read/28675375/specific-immunotherapy-in-hymenoptera-venom-allergy-and-concomitant-malignancies-a-retrospective-follow-up-focusing-on-efficacy-and-safety
#18
J Aeberhard, G Haeberli, U R Müller, A Helbling
BACKGROUND: Malignancies are often considered as a contraindication for allergen specific immunotherapy. This aspect must be discussed in regards to the population with severe Hymenoptera venom allergy and cancer. The aim of this retrospective study was to conduct a further examination of patients with Hymenoptera venom allergy, venom immunotherapy (VIT) and a malignancy. Methodology: All patients have been included who were referred for evaluation of a Hymenoptera venom allergy or for control during VIT from January 1, 2004 to December 31, 2008...
July 4, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28674481/pre-microporation-improves-outcome-of-pancreatic-islet-labelling-for-optical-and-19-f-mr-imaging
#19
Vít Herynek, Andrea Gálisová, Mangala Srinivas, Eric A W van Dinther, Lucie Kosinová, Jiri Ruzicka, Markéta Jirátová, Jan Kriz, Daniel Jirák
BACKGROUND: In vitro labelling of cells and small cell structures is a necessary step before in vivo monitoring of grafts. We modified and optimised a procedure for pancreatic islet labelling using bimodal positively charged poly(lactic-co-glycolic acid) nanoparticles with encapsulated perfluoro crown ethers and indocyanine green dye via microporation and compared the method with passive endocytosis. RESULTS: Pancreatic islets were microporated using two pulses at various voltages...
2017: Biological Procedures Online
https://www.readbyqxmd.com/read/28662542/quantitative-disease-progression-model-of-alpha-1-proteinase-inhibitor-therapy-on-ct-lung-density-in-patients-with-alpha-1-antitrypsin-deficiency
#20
M A Tortorici, J A Rogers, O Vit, M Bexon, R A Sandhaus, J Burdon, J Chorostowska-Wynimko, P Thompson, J Stocks, N G McElvaney, K R Chapman, J M Edelman
AIMS: Early-onset emphysema attributed to alpha-1 antitrypsin deficiency (AATD) is frequently overlooked and undertreated. RAPID-RCT/RAPID-OLE, the largest clinical trials of purified human alpha-1 proteinase inhibitor (A1 -PI; 60 mg/kg/wk) therapy completed to date, demonstrated for the first time that A1 -PI is clinically effective in slowing lung tissue loss in AATD. A post-hoc pharmacometric analysis was undertaken to further explore dose, exposure and response. METHODS: A disease progression model was constructed, utilizing observed A1 -PI exposure and lung density decline rates (measured by computed tomography) from RAPID-RCT/RAPID-OLE, to predict effects of population variability and higher doses on A1 -PI exposure and clinical response...
June 29, 2017: British Journal of Clinical Pharmacology
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