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https://www.readbyqxmd.com/read/28340373/influence-of-sex-on-cardiovascular-drug-responses-role-of-estrogen
#1
REVIEW
Abdel A Abdel-Rahman
In this review we discuss the sex/estrogen-specific modulation of cardiovascular function and responses to current therapeutics. We discuss how anatomical differences such as a smaller kidney size, and lower glomerular filtration rate in females, reduce the clearance and increase the toxicity of some drugs in females. Other important sex differences include the dampening effect of estrogen on central sympathetic and renin angiotensin systems. Further, we discuss how a shift in myocardial redox status leads to paradoxical transformation of estrogen into a pro-inflammatory hormone...
March 21, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28340299/bifurcation-of-regeneration-and-recombination-in-dye-sensitized-solar-cells-via-electronic-manipulation-of-tandem-cobalt-redox-shuttles
#2
Josh Baillargeon, Yuling Xie, Thomas W Hamann
A cobalt(IV/III) redox shuttle, cobalt tris(2-(p-tolyl)pyridine), [Co(ptpy)3]+/0, was synthesized and investigated for use in dye-sensitized solar cells, DSSCs. An incredibly fast self-exchange rate constant of (9.2  3.9) × 108 M-1s-1 was determined for [Co(ptpy)3]+/0, making it an ideal candidate for dye regeneration. To avoid fast recombination and solubility limitations, a tandem electrolyte containing [Co(ptpy)3]+/0 and cobalt tris(2,2'-bipyridine), [Co(bpy)3]3+/2+, was utilized. An improved short circuit current density is achieved for DSSCs employing the tandem electrolyte, compared to electrolytes containing only [Co(bpy)3]3+/2+, consistent with superior dye regeneration expected based on predictions using Marcus Theory, which is also discussed...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28340293/functional-paper-based-platform-for-rapid-capture-and-detection-of-ceo2-nanoparticles
#3
Ali Othman, Daniel Andreescu, Dinusha P Karunaratne, Suryadevara V Babu, Silvana Andreescu
Development of systems for capture, sequestration and tracking of nanoparticles (NPs) is becoming a significant focus in many aspects of nanotechnology and environmental research. These systems enable a broad range of applications for evaluating concentration, distribution and effects of NPs for environmental, clinical, epidemiological and occupational exposure studies. Herein, we describe the first example of a ligand-graft multifunctional platform for capture and detection of cerium oxide (CeO2 or ceria) NPs...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28338965/burrowers-from-the-past-mitochondrial-signatures-of-ordovician-bivalve-infaunalization
#4
Federico Plazzi, Guglielmo Puccio, Marco Passamonti
Bivalves and gastropods are the two largest classes of extant molluscs. Despite sharing a huge number of features, they do not share a key ecological one: gastropods are essentially epibenthic, while most bivalves are infaunal. However, this is not the ancestral bivalve condition; Cambrian forms were surface crawlers and only during the Ordovician a fundamental infaunalization process took place, leading to bivalves as we currently know them. This major ecological shift is linked to the exposure to a different redox environoments (hypoxic or anoxic) and with the Lower Devonian oxygenation event...
March 9, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28338762/redox-and-reactive-oxygen-species-network-in-acclimation-for-salinity-tolerance-in-sugar-beet
#5
M Sazzad Hossain, Abdelaleim Ismail ElSayed, Marten Moore, Karl-Josef Dietz
Fine-tuned and coordinated regulation of transport, metabolism and redox homeostasis allows plants to acclimate to osmotic and ionic stress caused by high salinity. Sugar beet is a highly salt tolerant crop plant and is therefore an interesting model to study sodium chloride (NaCl) acclimation in crops. Sugar beet plants were subjected to a final level of 300 mM NaCl for up to 14 d in hydroponics. Plants acclimated to NaCl stress by maintaining its growth rate and adjusting its cellular redox and reactive oxygen species (ROS) network...
February 18, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28338603/antioxidant-properties-of-selenophene-thiophene-and-their-aminocarbonitrile-derivatives
#6
Levon A Tavadyan, Zaruhi H Manukyan, Lusik H Harutyunyan, Makich V Musayelyan, Adrine D Sahakyan, Hakob G Tonikyan
The oxygen radical absorbance capacity (ORAC) method was used to detect the antiperoxyradical ability of organoselenium compounds: selenophene and its derivative, 2-amino-4,5,6,7-tetrahydro-1-selenophene-3-carbonitrile (ATSe); while as a comparison, the sulfur-containing analogue of selenophene-thiophene and its derivative-2-amino-4,5,6,7-tetrahydro-1-thiophene-3-carbonitrile (ATS)-was selected. Cyclic voltammetry (CV), differential pulse voltammetry (DPV) and squarewave voltammetry (SWV) methods were used to determine the redox characteristics of organoselenium and organosulfur compounds...
March 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28338335/stress-induced-protein-s-glutathionylation-and-s-trypanothionylation-in-african-trypanosomes-a-quantitative-redox-proteome-and-thiol-analysis
#7
Kathrin Ulrich, Caroline Finkenzeller, Sabine Merker, Federico Rojas, Keith Matthews, Thomas Ruppert, R Luise Krauth-Siegel
AIMS: Trypanosomatids have a unique trypanothione-based thiol redox metabolism. The parasite-specific dithiol is synthesized from glutathione and spermidine, with glutathionylspermidine as intermediate catalyzed by trypanothione synthetase. In this study, we address the oxidative stress response of African trypanosomes with special focus on putative protein S-thiolation. RESULTS: Challenging bloodstream Trypanosoma brucei with diamide, H2O2 or hypochlorite results in distinct levels of reversible overall protein S-thiolation...
March 24, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28338328/polysulfide-breathing-dual-conductive-heterolayered-battery-separator-membranes-based-on-0d-1d-mingled-nanomaterial-composite-mats
#8
Jeong-Hoon Kim, Gwan Yeong Jung, Yong-Hyeok Lee, Jung-Hwan Kim, Sun-Young Lee, Sang Kyu Kwak, Sang-Young Lee
Facile/sustainable utilization of sulfur active materials is an ultimate challenge in high-performance lithium-sulfur (Li-S) batteries. Here, as a membrane-driven approach to address this issue, we demonstrate a new class of polysulfide-breathing (capable of reversibly adsorbing and desorbing polysulfides)/dual (electron and ion)-conductive, heterolayered battery separator membranes (denoted as "MEC-AA separators") based on 0D (nanoparticles)/1D (nanofibers) composite mats. The MEC-AA separator is fabricated through an in-series, concurrent electrospraying/electrospinning process...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28338266/accelerated-oxygen-atom-transfer-and-c-h-bond-oxygenation-by-remote-redox-changes-in-fe3-mn-iodosobenzene-adducts
#9
Graham de Ruiter, Kurtis M Carsch, Sheraz Gul, Ruchira Chatterjee, Niklas B Thompson, Michael K Takase, Junko Yano, Theodor Agapie
We report the synthesis, characterization, and reactivity of [LFe3 (PhPz)3 OMn((s) PhIO)][OTf]x (3: x=2; 4: x=3), where 4 is one of very few examples of iodosobenzene-metal adducts characterized by X-ray crystallography. Access to these rare heterometallic clusters enabled differentiation of the metal centers involved in oxygen atom transfer (Mn) or redox modulation (Fe). Specifically, (57) Fe Mössbauer and X-ray absorption spectroscopy provided unique insights into how changes in oxidation state (Fe(III)2 Fe(II) Mn(II) vs...
March 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28338143/mastering-the-non-equilibrium-assembly-and-operation-of-molecular-machines
#10
Cristian Pezzato, Chuyang Cheng, J Fraser Stoddart, R Dean Astumian
In mechanically interlocked compounds, such as rotaxanes and catenanes, the molecules are held together by mechanical rather than chemical bonds. These compounds can be engineered to have several well-defined mechanical states by incorporating recognition sites between the different components. The rates of the transitions between the recognition sites can be controlled by introducing steric "speed bumps" or electrostatically switchable gates. A mechanism for the absorption of energy can also be included by adding photoactive, catalytically active, or redox-active recognition sites, or even charges and dipoles...
March 24, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28338141/structurally-related-hydrazone-based-metal-complexes-with-different-antitumor-activities-variably-induce-apoptotic-cell-death
#11
Dominik A Megger, Kristin Rosowski, Christian Radunsky, Jutta Kösters, Barbara Sitek, Jens Müller
Three new complexes bearing the tridentate hydrazone-based ligand 2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)pyridine (L) were synthesized and structurally characterized. Biological tests indicate that the Zn(ii) complex [ZnCl2(L)] is of low cytotoxicity against the hepatocellular carcinoma cell line HepG2. In contrast, the Cu(ii) and Mn(ii) complexes [CuCl2(L)] and [MnCl2(L)] are highly cytotoxic with EC50 values of 1.25 ± 0.01 μM and 20 ± 1 μM, respectively. A quantitative proteome analysis reveals that treatment of the cells with the Cu(ii) complex leads to a significantly altered abundance of 102 apoptosis-related proteins, whereas 38 proteins were up- or down-regulated by the Mn(ii) complex...
March 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28338131/structural-formation-and-charge-storage-mechanisms-for-intercalated-two-dimensional-carbides-mxenes
#12
Jing Wen, Xitian Zhang, Hong Gao
Although many studies have been focused on the characterization of MXenes, surface structures and formation mechanisms in terms of their experimental processes still remain controversial. Herein, we systematically investigated the structures formed from MX intercalated with different atoms from group IA to VIIA (A = H, Li, Na, K, Mg, Al, Si, P, O, S, F, and Cl) at different sites. An effective procedure based on first-principles calculations was developed to reveal the formation mechanisms of MAX, MXA2, MXTx, and MXTxAx' structures...
March 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28338004/tigar-knockdown-radiosensitizes-trxr1-overexpressing-glioma-in-vitro-and-in-vivo-via-inhibiting-trx1-nuclear-transport
#13
Yushuo Zhang, Fei Chen, Guomei Tai, Jiaojiao Wang, Jun Shang, Bing Zhang, Ping Wang, Baoxing Huang, Jie Du, Jiahua Yu, Haowen Zhang, Fenju Liu
The up-regulation of thioredoxin reductase-1 (TrxR1) is detected in more than half of gliomas, which is significantly associated with increased malignancy grade and recurrence rate. The biological functions of NADPH-dependent TrxR1 are mainly associated with reduced thioredoxin-1 (Trx1) which plays critical roles in cellular redox signaling and tumour radio-resistance. Our previous work has proved that TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown could notably radiosensitize glioma cells...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337705/the-effects-of-polyunsaturated-fatty-acids-and-antioxidant-vitamins-on-atrial-oxidative-stress-nitrotyrosine-residues-and-connexins-following-extracorporeal-circulation-in-patients-undergoing-cardiac-surgery
#14
Felipe Petersen, Ramón Rodrigo, Manfred Richter, Sawa Kostin
Cardiac surgery with extracorporeal circulation is characterized by different degrees of myocardial ischemia/reperfusion, which is often associated with postoperative atrial fibrillation (POAF). We have previously shown that a novel preventive therapy based on the reinforcement of the antioxidant system using omega-3 fatty acids plus antioxidant vitamin supplementation applied to patients undergoing cardiac surgery reduces POAF occurrence. We hypothesized that oxidative stress and nitrosative stress are involved in the development of an arrhythmogenic substrate by their effect on connexins (Cx40, Cx43 and Cx45) abundance and distribution pattern...
March 23, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28337249/cellular-homeostasis-and-antioxidant-response-in-epithelial-ht29-cells-on-titania-nanotube-arrays-surface
#15
Rabiatul Basria Smn Mydin, Srimala Sreekantan, Roshasnorlyza Hazan, Mustafa Fadzil Farid Wajidi, Ishak Mat
Cell growth and proliferative activities on titania nanotube arrays (TNA) have raised alerts on genotoxicity risk. Present toxicogenomic approach focused on epithelial HT29 cells with TNA surface. Fledgling cell-TNA interaction has triggered G0/G1 cell cycle arrests and initiates DNA damage surveillance checkpoint, which possibly indicated the cellular stress stimuli. A profound gene regulation was observed to be involved in cellular growth and survival signals such as p53 and AKT expressions. Interestingly, the activation of redox regulator pathways (antioxidant defense) was observed through the cascade interactions of GADD45, MYC, CHECK1, and ATR genes...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28336964/na-rich-layered-na2ti1-xcrxo3-x-2-x%C3%A2-%C3%A2-0-0-06-na-ion-battery-cathode-materials-with-high-capacity-and-long-cycle-life
#16
Shufeng Song, Masashi Kotobuki, Yingqian Chen, Sergei Manzhos, Chaohe Xu, Ning Hu, Li Lu
Rechargeable lithium batteries have been well-known and indispensable for portable electronic devices, and have the potential to be used in electric vehicles and smart grids. However, the growing concerns about the availability of lithium resources for large-scale applications have revived interest in sodium ion batteries. Of many obstacles to commercialization of Na-ion batteries, achieving simultaneously a large reversible capacity and good cycling capability of electrode materials remains a major challenge...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336528/platelet-cd36-promotes-thrombosis-by-activating-redox-sensor-erk5-in-hyperlipidemic-conditions
#17
Moua Yang, Brian C Cooley, Wei Li, Yiliang Chen, Jeannette Vasquez-Vivar, Na'il O Scoggins, Scott J Cameron, Craig N Morrell, Roy L Silverstein
Atherothrombosis is a process mediated by dysregulated platelet activation that can cause life-threatening complications and is the leading cause of death by cardiovascular disease. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in LDL particles, a process which induces an overt prothrombotic phenotype. The mechanisms by which CD36 promotes platelet activation and thrombosis remain incompletely defined. In this study, we identify a mechanism for CD36 to promote thrombosis by increasing activation of MAP kinase ERK5, a protein kinase known to be exquisitely sensitive to redox stress, through a signaling pathway requiring Src kinases, NADPH oxidase, superoxide radical anion and hydrogen peroxide...
March 23, 2017: Blood
https://www.readbyqxmd.com/read/28336403/broad-analysis-of-vicinal-disulfides-occurrences-conformations-with-cis-or-with-trans-peptides-and-functional-roles-including-sugar-binding
#18
Jane S Richardson, Lizbeth L Videau, Christopher J Williams, David C Richardson
Vicinal disulfides between sequence-adjacent cysteine residues are very rare and rather startling structural features which play a variety of functional roles. Typically discussed as an isolated curiosity, they have never received a general treatment covering both cis and trans forms. Enabled by the growing database of high-resolution structures, required deposition of diffraction data, and improved methods for discriminating reliable from dubious cases, we here identify and describe distinct protein families with reliably genuine examples of cis or trans vicinal disulfides and discuss their conformations, conservation, and functions...
March 20, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28336174/the-exposure-to-formaldehyde-causes-renal-dysfunction-inflammation-and-redox-imbalance-in-rats
#19
Camila de Oliveira Ramos, Clarissa Rodrigues Nardeli, Keila Karine Duarte Campos, Karina Braga Pena, Dafne Fernandes Machado, Ana Carla Balthar Bandeira, Guilherme de Paula Costa, André Talvani, Frank Silva Bezerra
Twenty-eight Fischer male rats were divided into four groups: control group (CG), exposed to the ambient air, and groups exposed to formaldehyde (FA) at concentrations of 1% (FA1%), 5% (FA5%) and 10% (FA10%). Kidney function was assessed by dosage of uric acid, creatinine and urea. Morphometry was performed on the thickness of the lumen of Bowman's capsule and diameter of the lumen of the renal tubules. We evaluated the redox imbalance through the catalase and superoxide dismutase activity as well as oxidative damage by lipid peroxidation...
March 20, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28336065/folding-and-dynamics-based-electrochemical-dna-sensors
#20
Rebecca Y Lai
A number of electrochemical DNA sensors based on the target-induced change in the conformation and/or flexibility of surface-bound oligonucleotides have been developed in recent years. These sensors, which are often termed E-DNA sensors, are comprised of an oligonucleotide probe modified with a redox label (e.g., methylene blue) at one terminus and attached to a gold electrode via a thiol-gold bond at the other. Binding of the target to the DNA probe changes its structure and dynamics, which, in turn, influences the efficiency of electron transfer to the interrogating electrode...
2017: Methods in Enzymology
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