M Giaccherini, M Rende, M Gentiluomo, C Corradi, L Archibugi, S Ermini, E Maiello, L Morelli, C H J van Eijck, G M Cavestro, M Schneider, A Mickevicius, K Adamonis, D Basso, V Hlavac, D Gioffreda, R Talar-Wojnarowska, B Schöttker, M Lovecek, G Vanella, M Gazouli, M Uno, E Malecka-Wojciesko, P Vodicka, M Goetz, M F Bijlsma, M C Petrone, F Bazzocchi, M Kiudelis, A Szentesi, S Carrara, G Nappo, H Brenner, A C Milanetto, P Soucek, V Katzke, G Peduzzi, C Rizzato, C Pasquali, X Chen, G Capurso, T Hackert, B Bueno-de-Mesquita, F G G Uzunoglu, P Hegyi, W Greenhalf, G E E Theodoropoulos, C Sperti, F Perri, M Oliverius, A Mambrini, F Tavano, R Farinella, P G Arcidiacono, M Lucchesi, S Bunduc, J Kupcinskas, G Di Franco, S Stocker, J P Neoptolemos, F Bambi, K Jamroziak, S G G Testoni, M N Aoki, B Mohelnikova-Duchonova, J R Izbicki, R Pezzilli, R T Lawlor, E F Kauffmann, E López de Maturana, N Malats, F Canzian, D Campa
Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls...
April 12, 2024: Mutagenesis