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Pancreatic function tests

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https://www.readbyqxmd.com/read/29146082/pancreatic-function-testing-for-the-early-diagnosis-of%C3%A2-chronic%C3%A2-pancreatitis
#1
EDITORIAL
Alexander Schlachterman, Chris E Forsmark
No abstract text is available yet for this article.
December 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29145315/iodine-125-seed-implantation-for-synchronous-pancreatic-metastases-from-hepatocellular-carcinoma-a-case-report-and-literature-review
#2
Junjie Xiong, Selina Kwong Chian, Jiao Li, Xubao Liu
RATIONALE: The image-guided iodine-125 seed implantation has been widely used for a variety of tumors, including prostatic cancer, pulmonary cancer, hepatocellular carcinoma and pancreatic cancer. However, the clinical value of iodine-125 seed implantation for the treatment of pancreatic metastasis from hepatocellular carcinoma has not been reported. We presented the first case with ultrasound-guided iodine-125 seed implantation for this disease. PATIENT CONCERNS: We presented the case of a 48-year-old man patient with primary hepatocellular carcinoma and pancreatic metastasis who was managed with ultrasound-guided iodine-125 seeds implantation...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134356/secretin-stimulated-ultrasound-estimation-of-pancreatic-secretion-in-cystic-fibrosis-validated-by-magnetic-resonance-imaging
#3
Trond Engjom, Erling Tjora, Gaute Wathle, Friedemann Erchinger, Birger N Lærum, Odd H Gilja, Ingfrid Salvesen Haldorsen, Georg Dimcevski
OBJECTIVES: Secretin-stimulated magnetic resonance imaging (s-MRI) is the best validated radiological modality assessing pancreatic secretion. The purpose of this study was to compare volume output measures from secretin-stimulated transabdominal ultrasonography (s-US) to s-MRI for the diagnosis of exocrine pancreatic failure in cystic fibrosis (CF). METHODS: We performed transabdominal ultrasonography and MRI before and at timed intervals during 15 minutes after secretin stimulation in 21 CF patients and 13 healthy controls...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29129820/deactivation-of-the-nlrp3-inflammasome-in-infiltrating-macrophages-by-duodenal-jejunal-bypass-surgery-mediates-improvement-of-beta-cell-function-in-type-2-diabetes
#4
Dong Wu, Zhi-Bo Yan, Yu-Gang Cheng, Ming-Wei Zhong, Shao-Zhuang Liu, Guang-Yong Zhang, San-Yuan Hu
OBJECTIVE: Bariatric surgery could improve pancreatic beta cell function, thereby leading to the remission of the type 2 diabetes mellitus (T2DM). However, the specific mechanism underlying this phenomenon is yet to be revealed. The aim of this study is to test the hypothesis that Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome in infiltrating macrophages plays an important role in the modulation of beta cell function after duodenal-jejunal bypass (DJB) surgery...
November 9, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29128386/a-pilot-study-of-endoscopically-inserted-biodegradable-biliary-stents-in-the-treatment-of-benign-biliary-strictures-and-cystic-duct-leaks
#5
Antti Siiki, Irina Rinta-Kiikka, Juhani Sand, Johanna Laukkarinen
BACKGROUND AND AIMS: Self-expanding biodegradable biliary stents (BDBSs) have recently become available for use in endoscopic retrograde cholangiography (ERC). The aim was to evaluate the effectiveness and safety of novel BDBS in iatrogenic cystic duct leaks and benign biliary strictures (BBSs). MATERIALS AND METHODS: Patients providing informed consent were recruited for the prospective study. Braided self-expanding poly-dioxanone BDBSs were inserted in ERC during the period 2012 to 2016...
November 8, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29127315/human-gingiva-derived-mesenchymal-stem-cells-ameliorate-streptozoticin-induced-t1dm-in-mice-via-suppression-of-t-effector-cells-and-up-regulating-treg-subsets
#6
Wei Zhang, Li Zhou, Junlong Dang, Ximei Zhang, Julie Wang, Yanming Chen, Jichao Liang, Dongqing Li, Jilin Ma, Jia Yuan, Weiwen Chen, Homayoun H Zadeh, Nancy Olsen, Song Guo Zheng
There is yet no cure for type 1 diabetes (T1DM) so far. A significant body of evidence has demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs) showed great potential in controlling T1DM. But there exists much difficulty in using BMSCs as a clinical therapy. We here test whether a new population of mesenchymal stem cells from human gingiva (GMSCs), which has many advantages over BMSCs, can delay or prevent progress of T1DM. GMSCs were adoptively transferred to multiple low-dose streptozotocin (STZ)-induced T1DM...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121795/berberine-ameliorates-diabetic-neuropathy-trpv1-modulation-by-pkc-pathway
#7
Yan Zan, Cui-Xing Kuai, Zhi-Xia Qiu, Fang Huang
In recent years, berberine has increasingly become a topic of research as a treatment for diabetes due to its repair function, which recovers damaged pancreatic β cells. However, it is the complications of diabetes that seriously affect patients' life quality and longevity, among which diabetic neuropathy and the consequent acute pain are the most common. In this study, we established STZ-induced diabetic models to observe whether berberine, a main constitute of Coptis chinensis Franch which has shown good hypoglycemic effects, could relieve diabetes-induced pain and explored its possible mechanism in rats and mice...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29118564/sex-related-differences-in-predicting-choledocholithiasis-using-current-american-society-of-gastrointestinal-endoscopy-risk-criteria
#8
Ankit Chhoda, Deepanshu Jain, Shashideep Singhal
Background: American Society of Gastrointestinal Endoscopy (ASGE) criteria is widely used to predict probability of choledocholithiasis among patients with symptomatic gallstone disease but does not take sex into consideration. Methods: The cohort study included patients who underwent either endoscopic retrograde cholangiopancreatography or intraoperative cholangiography for suspected choledocholithiasis at our medical center. Clinical, laboratory and radiological data were collected for each patient and used to stratify them based on the ASGE risk criteria for choledocholithiasis...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29118024/arsenic-exposure-induces-glucose-intolerance-and-alters-global-energy-metabolism
#9
Andrew G Kirkley, Christopher M Carmean, Daniel Ruiz, Honggang Ye, Shane M Regnier, Ananta Poudel, Manami Hara, Wakanene Kamau, Daniel N Johnson, Austin A Roberts, Patrick J Parsons, Susumu Seino, Robert Michael Sargis
Environmental pollutants acting as endocrine disrupting chemicals (EDCs) are recognized as potential contributors to metabolic disease pathogenesis. One such pollutant, arsenic, contaminates the drinking water of approximately 100 million people globally and has been associated with insulin resistance and diabetes in epidemiological studies. Despite these observations, the precise metabolic derangements induced by arsenic remain incompletely characterized. In the present study, arsenic's impact on in vivo metabolic physiology was examined in 8 week old male C57BL/6J mice exposed to 50 mg/L inorganic arsenite in their drinking water for 8 weeks...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29104871/smoking-gender-and-overweight-are-important-influencing-factors-on-monocytic-hla-dr-before-and-after-major-cancer-surgery
#10
Gunnar Lachmann, Clarissa von Haefen, Johannes Kurth, Fatima Yuerek, Klaus-Dieter Wernecke, Claudia Spies
Background: Monocytic human leukocyte antigen D related (mHLA-DR) is essential for antigen-presentation. Downregulation of mHLA-DR emerged as a general biomarker of impaired immunity seen in patients with sepsis and pneumonia and after major surgery. Influencing factors of mHLA-DR such as age, overweight, diabetes, smoking, and gender remain unclear. Methods: We analyzed 20 patients after esophageal or pancreatic resection of a prospective, randomized, placebo-controlled, double-blind trial (placebo group)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29099080/effect-of-saturated-stearic-acid-on-map-kinase-and-er-stress-signaling-pathways-during-apoptosis-induction-in-human-pancreatic-%C3%AE-cells-is-inhibited-by-unsaturated-oleic-acid
#11
Jan Šrámek, Vlasta Němcová-Fürstová, Nela Pavlíková, Jan Kovář
It has been shown that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to apoptosis, whereas unsaturated FAs are well tolerated and are even capable of inhibiting the pro-apoptotic effect of saturated FAs. Molecular mechanisms of apoptosis induction and regulation by FAs in β-cells remain unclear; however, mitogen-activated protein (MAP) kinase and endoplasmic reticulum (ER) stress signaling pathways may be involved. In this study, we tested how unsaturated oleic acid (OA) affects the effect of saturated stearic acid (SA) on the p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) pathways as well as the ER stress signaling pathways during apoptosis induction in the human pancreatic β-cells NES2Y...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29098391/fetal-sex-influences-maternal-fasting-plasma-glucose-levels-and-basal-%C3%AE-cell-function-in-pregnant-women-with-normal-glucose-tolerance
#12
Xinqian Geng, Lulu Geng, Yinan Zhang, Huijuan Lu, Yixie Shen, Ruihua Chen, Pingyan Fang, Minfang Tao, Congrong Wang, Weiping Jia
AIMS: Fetal sex has recently emerged as a new factor that is related to maternal glucose homeostasis during pregnancy. The present study aimed to investigate the effect of fetal sex on maternal glucose metabolism in women with normal glucose tolerance (NGT) during pregnancy in the Chinese population. METHODS: A total of 877 pregnant women with NGT were recruited at 24-28 weeks of gestation and underwent a 75-g oral glucose tolerance test (OGTT). Pregnant women were divided into two groups according to fetal sex...
November 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29097865/staging-chronic-pancreatitis-with-exocrine-function-tests-are-we-better
#13
EDITORIAL
Cosimo Sperti, Lucia Moletta
Chronic pancreatitis (CP) is an inflammatory disease of the pancreas evolving in progressive fibrotic disruption of the gland with exocrine and endocrine pancreatic insufficiency. Although imaging features of CP are well known, their correlation with exocrine pancreatic function tests are not obvious, particularly in the early stage of the disease. There are many clinical classification of CP, all suggested for better distinguish and manage different forms based on etiological and clinical factors, and severity of the disease...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29097671/functional-coupling-of-human-pancreatic-islets-and-liver-spheroids-on-a-chip-towards-a-novel-human-ex-vivo-type-2-diabetes-model
#14
Sophie Bauer, Charlotte Wennberg Huldt, Kajsa P Kanebratt, Isabell Durieux, Daniela Gunne, Shalini Andersson, Lorna Ewart, William G Haynes, Ilka Maschmeyer, Annika Winter, Carina Ämmälä, Uwe Marx, Tommy B Andersson
Human in vitro physiological models studying disease and drug treatment effects are urgently needed as more relevant tools to identify new drug targets and therapies. We have developed a human microfluidic two-organ-chip model to study pancreatic islet-liver cross-talk based on insulin and glucose regulation. We have established a robust co-culture of human pancreatic islet microtissues and liver spheroids maintaining functional responses up to 15 days in an insulin-free medium. Functional coupling, demonstrated by insulin released from the islet microtissues in response to a glucose load applied in glucose tolerance tests on different days, promoted glucose uptake by the liver spheroids...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093273/genetic-determinants-of-circulating-gip-and-glp-1-concentrations
#15
Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa Hakaste, Emilia Ottosson-Laakso, Olof Asplund, Emily Sonestedt, Rashmi B Prasad, Esa Laurila, Marju Orho-Melander, Olle Melander, Tiinamaija Tuomi, Jens Juul Holst, Peter M Nilsson, Nils Wierup, Leif Groop, Emma Ahlqvist
The secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) from the gastrointestinal tract is essential for glucose homeostasis. Several novel treatment strategies for type 2 diabetes (T2D) mimic GLP-1 actions or inhibit incretin degradation (DPP4 inhibitors), but none is thus far aimed at increasing the secretion of endogenous incretins. In order to identify new potential therapeutic targets for treatment of T2D, we performed a meta-analysis of a GWAS and an exome-wide association study of circulating insulin, glucagon, GIP, and GLP-1 concentrations measured during an oral glucose tolerance test in up to 7,828 individuals...
November 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/29091592/procalcitonin-and-pancreatic-stone-protein-function-as-biomarkers-in-early-diagnosis-of-pediatric-acute-osteomyelitis
#16
Chunmiao Cui, Muyong Fu, Boqian Gao
BACKGROUND High plasma levels of procalcitonin (PCT) are typically seen in children with severe bacterial infection, particularly in cases of septic shock or bacteremia. Similarly, pancreatic stone protein (PSP) is associated with inflammation, infection, and other disease-related stimuli. However, the prognostic value of PSP in critically ill pediatric patients is unknown. This study investigated the early diagnostic value of PCT and PSP in pediatric acute osteomyelitis. MATERIAL AND METHODS A total of 187 patients with suspected acute osteomyelitis and 80 healthy control children were enrolled...
November 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29078749/endocrine-and-exocrine-pancreatic-insufficiency-after-acute-pancreatitis-long-term-follow-up-study
#17
Jianfeng Tu, Jingzhu Zhang, Lu Ke, Yue Yang, Qi Yang, Guotao Lu, Baiqiang Li, Zhihui Tong, Weiqin Li, Jieshou Li
BACKGROUND: Patients could develop endocrine and exocrine pancreatic insufficiency after acute pancreatitis (AP), but the morbidity, risk factors and outcome remain unclear. The aim of the present study was to evaluate the incidence of endocrine and exocrine pancreatic insufficiency after AP and the risk factors of endocrine pancreatic insufficiency through a long-term follow-up investigation. METHODS: Follow-up assessment of the endocrine and exocrine function was conducted for the discharged patients with AP episodes...
October 27, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29075857/preoperative-imaging-overestimates-the-tumor-size-in-pancreatic-neuroendocrine-neoplasms-associated-with-multiple-endocrine-neoplasia-type-1
#18
V Polenta, E P Slater, P H Kann, M B Albers, J Manoharan, A Ramaswamy, A H Mahnken, D K Bartsch
BACKGROUND: Radiological tumor size of non-functioning pancreatic neuroendocrine neoplasms (Nf-pNENs) associated with multiple endocrine neoplasia type 1 (MEN1) is a crucial parameter to indicate surgery. The aim of this study was to compare radiological size (RS) and pathologic size (PS) of MEN1 associated with pNENs. METHODS: Prospectively collected data of MEN1 patients who underwent pancreatic resections for pNENs were retrospectively analyzed. RS was defined as the largest tumor diameter measured on endoscopic ultrasound (EUS), magnetic resonance imaging (MRI) or computed tomography (CT)...
October 26, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29066484/aminoguanidine-ag-induces-induced-both-pro-and-antioxidant-effect-in-ar42j-cells-a-rat-pancreatic-tumor-cell-line
#19
Parimal Chowdhury
Aminoguanidine (AG), a diamine oxidase and a nitric oxide synthase inhibitor, was used in diabetes, thyroid follicular carcinoma, hepatocellular carcinoma, pancreatic cancer xenografts and in breast cancer research. The effects of AG on these pathologic conditions may be related to its regulatory effects on cell proliferation, angiogenesis, and expression of antioxidant enzymes. However, its role as pro and/or anti-oxidant affecting signaling and function in pancreatic tumor cell lines has not been studied...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29062619/choledocholithiasis-treatment-options-in-a-tertiary-care-setup-in-pakistan
#20
Ramlah Ghazanfor, Naeem Liaqat, Mehwish Changeez, Maham Tariq, Sara Malik, Khawaja R Ghazanfar, Jahangir S Khan
Introduction Among patients with cholelithiasis, choledocholithiasis may also be present in about 18% of cases. They can be treated through various endoscopic, laparoscopic, and open surgical procedures. Objective The objective of this study was to determine the outcome of patients with choledocholithiasis being treated in our setup. Methods This descriptive case series was conducted at Holy Family Hospital, Rawalpindi, Pakistan over two years from January 2015 to December 2016. All patients with choledocholithiasis admitted to Surgical Unit 1 were included in this study...
August 21, 2017: Curēus
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