keyword
https://read.qxmd.com/read/38288084/severe-pulmonary-hypertension-interstitial-lung-disease-presenting-as-right-ventricular-failure-stabilisation-with-intravenous-prostacyclin-and-maintenance-with-inhaled-prostacyclin
#21
JOURNAL ARTICLE
Raj Parikh, Alysse Thomas, Aldo Sharofi, Niala Moallem, Garrett Fiscus, Harrison W Farber
BACKGROUND: Pulmonary hypertension (PH) leads to increased morbidity and mortality in interstitial lung disease (ILD). While the INCREASE trial highlighted the use of inhaled prostacyclin in PH-ILD patients, such therapy may be inadequate when right ventricular failure (RVF) is also present. In this study, we report the use of intravenous prostacyclin in three PH-ILD patients to stabilise right ventricular (RV) function, with a subsequent transition to maintenance therapy with inhaled prostacyclin...
January 2024: ERJ Open Research
https://read.qxmd.com/read/38286715/15-hydroxyeicosatrienoic-acid-induces-nasal-congestion-by-changing-vascular-functions-in-mice
#22
JOURNAL ARTICLE
Noriko Ozaki, Naoaki Sakamoto, Daiki Horikami, Yuri Tachibana, Nanae Nagata, Koji Kobayashi, Yoshino Taira Arai, Masayoshi Sone, Kazuhiro Hirayama, Takahisa Murata
BACKGROUND: Nasal congestion in allergic rhinitis (AR) is caused by vascular hyperpermeability and vascular relaxation of the nasal mucosa. We previously detected high levels of a lipoxygenation metabolite of dihomogammalinolenic acid, 15-hydroxy-8Z,11Z,13E-eicosatrienoic acid (15-HETrE) in the nasal lavage fluid of AR model mice. Here, we investigated the effects of 15-HETrE on vascular functions associated with nasal congestion. METHODS: We measured 15-HETrE levels in the nasal lavage fluid of ovalbumin-induced AR model mice and nasal discharge of patients with AR...
January 28, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/38281939/short-term-effect-of-intravenous-treprostinil-in-term-and-preterm-infants-with-pulmonary-hypertension
#23
JOURNAL ARTICLE
Yoo-Jin Kim, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim
BACKGROUND: Pulmonary hypertension (PH) is a life-threatening condition in newborns. We aimed to assess the clinical and echocardiographic responses of term and preterm infants to treprostinil. METHODS: This retrospective study included newborns diagnosed with PH and treated with treprostinil as additional therapy after inhaled nitric oxide administration in the neonatal intensive care unit of a tertiary center. Term and preterm infants were compared in terms of echocardiographic findings and clinical findings 4 weeks after treprostinil treatment...
January 29, 2024: BMC Pediatrics
https://read.qxmd.com/read/38278584/perioperative-management-of-novel-pharmacotherapies-for-heart-failure-and-pulmonary-hypertension
#24
REVIEW
Caroline R Gross, Robin Varghese, Zdravka Zafirova
Heart failure (HF) and pulmonary hypertension (PH) are increasingly prevalent comorbidities in patients presenting for noncardiac surgery. The unique pathophysiology and pharmacotherapies associated with these syndromes have important perioperative implications. As new medications for HF and PH emerge, it is imperative that anesthesiologists and other perioperative providers understand their mechanisms of action, pharmacokinetics, and potential adverse effects. We present an overview of the novel HF and PH pharmacotherapies and strategies for their perioperative management...
March 2024: Anesthesiology Clinics
https://read.qxmd.com/read/38277953/alterations-of-prostanoid-expression-and-intestinal-epithelial-barrier-functions-in-ileus
#25
JOURNAL ARTICLE
Anne Bessard, Claire Cardaillac, Thibauld Oullier, Nicolas Cenac, Malvyne Rolli-Derkinderen, Michel Neunlist, Aurélien Venara
INTRODUCTION: Intestinal manipulation (IM)-induced inflammation could contribute to postoperative ileus (POI) pathophysiology via the modulation of prostanoid pathways. To identify the prostanoids involved, we aimed to characterize the profile of prostanoids and their synthesis enzyme expression in a murine model of POI and to determine whether the altered prostanoids could contribute to POI. METHODS: Four or 14 h after IM in mice, gastrointestinal (GI) motility and intestinal epithelial barrier (IEB) permeability were assessed in vivo and ex vivo in Ussing chambers...
January 25, 2024: Journal of Surgical Research
https://read.qxmd.com/read/38256697/inhaled-pulmonary-vasodilators-for-the-treatment-of-right-ventricular-failure-in-cardio-thoracic-surgery-is-one-better-than-the-others
#26
REVIEW
Maria Benedetto, Giulia Piccone, Leonardo Gottin, Andrea Castelli, Massimo Baiocchi
Right ventricular failure (RFV) is a potential complication following cardio-thoracic surgery, with an incidence ranging from 0.1% to 30%. The increase in pulmonary vascular resistance (PVR) is one of the main triggers of perioperative RVF. Inhaled pulmonary vasodilators (IPVs) can reduce PVR and improve right ventricular function with minimal systemic effects. This narrative review aims to assess the efficacy of inhaled nitric oxide and inhaled prostacyclins for the treatment of perioperative RVF. The literature, although statistically limited, supports the clinical similarity between them...
January 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38233271/dietary-inflammation-index-association-with-serum-levels-of-nitric-oxide-prostacyclin-and-thromboxane-b2-among-prinzmetal-angina-patients-and-healthy-persons
#27
JOURNAL ARTICLE
Mahsa Mohajeri, Arrigo F G Cicero
BACKGROUND AND AIM: This study aimed to assess the association between dietary inflammation index with serum Nitric oxide, Prostacyclin, and Thromboxane B2 among Prinzmetal angina patients and healthy persons. METHODS AND RESULTS: This case-control study was conducted among 120 Prinzmetal angina patients and 120 healthy persons referred to the Ardabil Imam Khomeini Hospital between 2021 and 2022. Blood samples were gained from all study participants for measurement of serum Nitric oxide, Prostacyclin, and Thromboxane B2...
December 2, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38202148/long-term-survival-of-heritable-pulmonary-arterial-hypertension-associated-with-hereditary-hemorrhagic-telangiectasia-a-case-series
#28
JOURNAL ARTICLE
Parth Jamindar, Michael Pope, James Gossage
Hereditary hemorrhagic telangiectasia (HHT) is a hereditary disease characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. Multiple genetic mutations have been linked to this rare disease, including ENG, ALK1 (ACVRL1), and MADH4. Pulmonary hypertension is a potential complication of HHT, with the most common phenotypes being World Health Organization (WHO) group 1 heritable pulmonary arterial hypertension (PAH), which is typically associated with ALK1 mutation; WHO group 2 pulmonary hypertension due to high output heart failure from hepatic arteriovenous malformations and/or anemia; and WHO group 2 due to high pulmonary artery wedge pressure...
December 27, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38198043/ralinepag-phase%C3%A2-ii-open-label-extension-study-in-patients-with-pulmonary-arterial-hypertension
#29
JOURNAL ARTICLE
Joan Barberà, Pavel Jansa, Elizabeth Klings, Arsen Ristić, Anne Keogh, Derek Solum, Youlan Rao, Rob Grover, Isil Saib, Namita Sood
INTRODUCTION: Ralinepag is a potent, titratable, orally administered prostacyclin (IP) receptor agonist to treat pulmonary arterial hypertension. A phase II randomized, double-blind, parallel-group, placebo-controlled, 22-week study of immediate-release (IR) ralinepag safety and efficacy met its primary endpoint, significantly reducing pulmonary vascular resistance (PVR) compared with placebo. This phase II open-label extension (OLE) study assessed long-term safety and tolerability of ralinepag...
January 10, 2024: Advances in Therapy
https://read.qxmd.com/read/38189593/anticoagulation-for-people-receiving-long-term-haemodialysis
#30
REVIEW
Patrizia Natale, Suetonia C Palmer, Marinella Ruospo, Henrietta Longmuir, Benjamin Dodds, Ritam Prasad, Tracey J Batt, Matthew D Jose, Giovanni Fm Strippoli
BACKGROUND: Haemodialysis (HD) requires safe and effective anticoagulation to prevent clot formation within the extracorporeal circuit during dialysis treatments to enable adequate dialysis and minimise adverse events, including major bleeding. Low molecular weight heparin (LMWH) may provide a more predictable dose, reliable anticoagulant effects and be simpler to administer than unfractionated heparin (UFH) for HD anticoagulation, but may accumulate in the kidneys and lead to bleeding...
January 8, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38180559/long-term-efficacies-of-selective-vasodilators-in-pulmonary-arterial-hypertension-a-comprehensive-comparison-using-a-spontaneous-reporting-database
#31
JOURNAL ARTICLE
Koji Suzuki, Tatsuya Yagi, Junichi Kawakami
There is no clinical evidence of differences in drugs associated with long-term survival in patients with pulmonary arterial hypertension (PAH) due to the small population and lack of information on death in Japanese medical database systems. This study evaluated whether patient data from a spontaneous reporting database could be used for comparing the effects of pulmonary vasodilators on long-term survival in PAH patients. PAH patient data reported in the Japanese Adverse Drug Event Report (JADER) database from April 2004 to July 2022 were extracted...
January 5, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38176461/p75ntr-regulates-autophagy-through-the-yap-mtor-pathway-to-increase-the-proliferation-of-interfollicular-epidermal-cells-and-promote-wound-healing-in-diabetic-mice
#32
JOURNAL ARTICLE
Zhenjie Wu, Chunyan Liu, Siyuan Yin, Jiaxu Ma, Rui Sun, Guoqi Cao, Yongpan Lu, Jian Liu, Linqi Su, Ru Song, Yibing Wang
Wound healing is delayed in diabetic patients. Increased autophagy and dysfunction of interfollicular epidermal (IFE) cells are closely associated with delayed healing of diabetic wounds. Autophagy plays an important role in all stages of wound healing, but its role in diabetic wound healing and the underlying molecular mechanisms are not clear. Here, we found that diabetic mice had delayed wound healing and increased autophagy in wounds compared with normal mice and that chloroquine, an inhibitor of autophagy, decreased the level of autophagy, improved the function of IFE cells, and accelerated wound healing in diabetic mice...
January 2, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38169336/epoprostenol-prostacyclin-analog-as-a-sole-anticoagulant-in-continuous-renal-replacement-therapy-for-critically-ill-children-with-liver-disease-single-center-retrospective-study-2010-2019
#33
JOURNAL ARTICLE
Akash Deep, Emma C Alexander, Anuj Khatri, Nisha Kumari, Kalyan Sudheendhra, Prithvi Patel, Amina Joarder, Ismail Elghuwael
OBJECTIVES: Despite deranged coagulation, children with liver disease undergoing continuous renal replacement therapy (CRRT) are prone to circuit clotting. Commonly used anticoagulants (i.e., heparin and citrate) can have side effects. The aim of this study was to describe our experience of using epoprostenol (a synthetic prostacyclin analog) as a sole anticoagulant during CRRT in children with liver disease. DESIGN: Single-center, retrospective study, 2010-2019...
January 1, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38163560/danhong-formula-alleviates-endothelial-dysfunction-and-reduces-blood-pressure-in-hypertension-by-regulating-microrna-24-phosphatidylinositol-3-kinase-serine-threonine-kinase-endothelial-nitric-oxide-synthase-axis
#34
JOURNAL ARTICLE
Xiaohu Yang, Wenchao Yang, Shuang He, He Ye, Shanshan Lei
ETHNOPHARMACOLOGICAL RELEVANCE: Essential hypertension (EH) is one of the important risk factors of cardio-cerebrovascular diseases, and it can significantly increase the incidence and mortality of acute myocardial infarction, cerebral infarction and hemorrhage. Danhong Formula (DHF) was consisting of Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Labiatae, Danshen in Chinese) and Flos Carthami (Carthamus tinctorius L., Compositae, Honghua in Chinese) (Plant names have been checked with https://www...
December 30, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38158135/comparative-effectiveness-of-oral-therapies-targeting-the-prostacyclin-pathway-in-pulmonary-arterial-hypertension-a-systematic-review-and-network-meta-analysis
#35
JOURNAL ARTICLE
Giovanna Manzi, Marco Valerio Mariani, Domenico Filomena, Silvia Papa, Tommaso Recchioni, Gianmarco Scoccia, Carmine Dario Vizza, Roberto Badagliacca
BACKGROUND: Oral prostanoids are recommended in patients with pulmonary arterial hypertension (PAH) and a unsatisfactory response to first-line therapy. OBJECTIVE: To compare effectiveness of oral therapies targeting the prostacyclin pathway in PAH patients. METHODS: An online search of Medline, Cochrane Registry, Scopus and EMBASE libraries (from inception to May, 12020) was performed. Eight randomized controlled studies were included in the meta-analysis involving 3023 patients, of whom 828 receiving oral treprostinil, 607 patients receiving selexipag, 125 patients receiving beraprost, and 1463 patients received placebo...
December 27, 2023: International Journal of Cardiology
https://read.qxmd.com/read/38139268/antarctic-krill-oil-from-euphausia-superba-ameliorates-carrageenan-induced-thrombosis-in-a-mouse-model
#36
JOURNAL ARTICLE
Gi Ho Lee, Seung Yeon Lee, Ju Yeon Chae, Jae Won Kim, Jin-Hee Kim, Hye Gwang Jeong
FJH-KO obtained from Antarctic krill, especially Euphausia superba , has been reported to contain high amounts of omega-3 polyunsaturated fatty acids (n-3 PUFA) and to exhibit anticancer and anti-inflammatory properties. However, its antithrombotic effects have not yet been reported. This study aimed to investigate the antithrombotic effects of FJH-KO in carrageenan-induced thrombosis mouse models and human endothelial cells. Thrombosis was induced by carrageenan injection, whereas the mice received FJH-KO pretreatment...
December 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38132665/pulmonary-vasodilator-therapy-in-severe-pulmonary-hypertension-due-to-chronic-obstructive-pulmonary-disease-severe-ph-copd-a-systematic-review-and-meta-analysis
#37
REVIEW
Ahmed Elkhapery, M Bakri Hammami, Roxana Sulica, Hemanth Boppana, Zeinab Abdalla, Charoo Iyer, Hazem Taifour, Chengu Niu, Himanshu Deshwal
Background: Chronic obstructive pulmonary disease-associated pulmonary hypertension (PH-COPD) results in a significant impact on symptoms, quality of life, and survival. There is scant and conflicting evidence about the use of pulmonary hypertension (PH) specific therapy in patients with PH-COPD. Study Design and Methods: PubMed, OVID, CINAHL, Cochrane, Embase, and Web of Science were searched using various MESH terms to identify randomized controlled trials (RCTs) or observational studies investigating PH-specific therapies in patients with severe PH-COPD, defined by mean pulmonary artery pressure (mPAP) of more than 35 mm Hg or pulmonary vascular resistance (PVR) of more than 5 woods units on right heart catheterization...
December 16, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38108945/use-of-the-national-cancer-institute-patient-reported-outcomes-version-of-the-common-terminology-criteria-for-adverse-events-to-assess-treatment-tolerability-in-pulmonary-arterial-hypertension-qualitative-patient-research-findings-in-current-and-former-users
#38
JOURNAL ARTICLE
Stacy Davis, Teresa Edwards, Lindsey Norcross, Sheri Fehnel, Amélie Beaudet, Marie Eckart, John Fastenau
BACKGROUND: Understanding patients' perspectives regarding drug tolerability, in addition to effectiveness, provides a complete picture of the patient experience and supports more informed therapeutic decision-making. The item library of the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) was developed to measure patient-reported frequency, severity, and interference of adverse events (AEs) associated with cancer therapies...
December 18, 2023: Journal of Patient-Reported Outcomes
https://read.qxmd.com/read/38086148/prenatal-treprostinil-improves-pulmonary-arteriolar-hypermuscularization-in-the-rabbit-model-of-congenital-diaphragmatic-hernia
#39
JOURNAL ARTICLE
Felix R De Bie, Yannick Regin, Antoine Dubois, Marianna Scuglia, Tomohiro Arai, Ewout Muylle, David Basurto, Marius Regin, Siska Croubels, Marc Cherlet, Emily A Partridge, Karel Allegaert, Francesca M Russo, Jan A Deprest
Congenital diaphragmatic hernia (CDH) is a congenital malformation characterized by pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction. Pulmonary hypertension represents the major cause of neonatal mortality and morbidity. Prenatal diagnosis allows assessment of severity and selection of foetal surgery candidates. We have shown that treprostinil, a prostacyclin analogue with an anti-remodelling effect, attenuates the relative hypermuscularization of the pulmonary vasculature in rats with nitrofen-induced CDH...
December 11, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38072923/frostbite-treatment-a-systematic-review-with-meta-analyses
#40
REVIEW
Ivo B Regli, Rosmarie Oberhammer, Ken Zafren, Hermann Brugger, Giacomo Strapazzon
INTRODUCTION: Our objective was to perform a systematic review of the outcomes of various frostbite treatments to determine which treatments are effective. We also planned to perform meta-analyses of the outcomes of individual treatments for which suitable data were available. MAIN BODY: We performed a systematic review and meta-analyses in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We searched PubMed, Cochrane Trials, and EMBase to identify primary references from January 1, 1900, to June 18, 2022...
December 11, 2023: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
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