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Prostacyclin

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https://www.readbyqxmd.com/read/29325908/corrigendum-to-rosuvastatin-inhibits-pressure-induced-fibrotic-responses-via-the-expression-regulation-of-prostacyclin-and-prostaglandin-e-2-in-rat-renal-tubular-cells-european-journal-of-pharmacology-700-2013-65-73
#1
Cheng-Hsien Chen, Chung-Yi Cheng, Yen-Cheng Chen, Yuh-Mou Sue, Yung-Ho Hsu, Wei-Lun Tsai, Tso-Hsiao Chen
No abstract text is available yet for this article.
January 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29313743/express-resource-utilization-at-the-time-of-prostacyclin-initiation-in-children-in-pulmonary-arterial-hypertension-a-multicenter-analysis
#2
Stephen Hart, Gaurav Arora, Brian Feingold
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29307087/targeting-the-prostacyclin-pathway-with-selexipag-in-patients-with-pulmonary-arterial-hypertension-receiving-double-combination-therapy-insights-from-the-randomized-controlled-griphon-study
#3
J Gerry Coghlan, Richard Channick, Kelly Chin, Lilla Di Scala, Nazzareno Galiè, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Irene M Lang, Vallerie McLaughlin, Ralph Preiss, Lewis J Rubin, Gérald Simonneau, Olivier Sitbon, Victor F Tapson, Sean Gaine
BACKGROUND: In pulmonary arterial hypertension (PAH), combination therapy is an important treatment strategy. Although randomized controlled trial data are available to support the combination of two therapies, data regarding triple combination therapy are few. OBJECTIVE: The phase III GRIPHON trial enrolled 1156 patients with PAH, including 376 receiving background double combination therapy. We evaluated the efficacy and safety of selexipag as a third agent in these patients and further analyzed this subgroup according to symptom burden at baseline as indicated by World Health Organization (WHO) functional class (FC)...
January 6, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29305668/iloprost-affects-macrophage-activation-and-ccl2-concentrations-in-a-microdialysis-model-in-rats
#4
Kamel Alkhatib, Tina M Poseno, Alda Diaz Perez, Jeannine M Durdik, Julie A Stenken
PURPOSE: The hypothesis that locally-released iloprost, a synthetic prostacyclin analog, affects macrophage phenotype at a microdialysis implant in the subcutaneous space of rats was tested. Macrophage activation towards alternatively-activated phenotypes using pharmaceutical release is of interest to improve integration of implants and direct the foreign body reaction toward a successful outcome. METHODS: Macrophage cell culture was used to test iloprost macrophage activation in vitro...
January 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29298774/kidney-transplantation-in-a-patient-lacking-cytosolic-phospholipase-a2-proves-renal-origins-of-urinary-pgi-m-and-tx-m
#5
Jane Mitchell, Rebecca B Knowles, Nicholas S Kirkby, Daniel M Reed, Matthew L Edin, William E White, Melissa V Chan, Hilary Longhurst, Magdi Yaqoob, Ginger L Milne, Darryl C Zeldin, Timothy D Warner
Rationale: The balance between vascular prostacyclin which is anti-thrombotic and platelet thromboxane A2 which is pro-thrombotic is fundamental to cardiovascular health. Prostacyclin and thromboxane A2 are formed following the concerted actions of cytosolic phospholipase A2 (cPLA2α) and cyclooxygenase. Urinary 2,3-dinor-6-keto PGF1α (PGI-M) and 11-dehydro-TXB2 (TX-M) have been taken as biomarkers of prostacyclin and thromboxane A2 formation with the circulation and used to explain cyclooxygenase biology and patient phenotypes, despite concerns that urinary PGI-M and TX-M originate in the kidney...
January 3, 2018: Circulation Research
https://www.readbyqxmd.com/read/29297976/platelet-responses-to-pharmacological-and-physiological-interventions-in-middle-aged-men-with-different-habitual-physical-activity-levels
#6
M H Lundberg Slingsby, L Gliemann, M Thrane, N Rytter, J Egelund, M V Chan, P C Armstrong, T D Warner, Y Hellsten
The current guidelines following an acute coronary syndrome recommend dual anti-platelet therapy (aspirin plus a P2Y12 antagonist) alongside lifestyle modifications, including more regular physical activity. It is currently unknown if regular exercise affects the pharmacology of dual anti-platelet therapy. AIM: To explore how exercise-induced improvements in vascular and platelet function affect the efficacy of dual anti-platelet therapy, in a cross-sectional study of men with different physical activity level (training status)...
January 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29296755/12-hetre-inhibits-platelet-reactivity-and-thrombosis-in-part-through-the-prostacyclin-receptor
#7
Benjamin E Tourdot, Reheman Adili, Zitha R Isingizwe, Meral Ebrahem, J Cody Freedman, Theodore R Holman, Michael Holinstat
The dihomo-γ-linolenic acid (DGLA)-derived metabolite of 12-lipoxygenase, 12-hydroxy-eicosatrienoic acid (12-HETrE), was recently shown to potently inhibit thrombus formation without prolonging bleeding in murine models. Although 12-HETrE was found to inhibit platelet activation via the Gαs signaling pathway, the Gαs-coupled receptor by which 12-HETrE mediates its antiplatelet effects has yet to be identified. Defining the receptor by which 12-HETrE exerts its effects is key to determining its therapeutic potential as an antiplatelet drug...
June 27, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295855/the-%C3%AE-2-agonist-terbutaline-specifically-decreases-pulmonary-arterial-pressure-under-normoxia-and-hypoxia-via-%C3%AE-adrenoceptor-antagonism
#8
Vanessa Neumann, Ralf Knies, Alexander Seidinger, Annika Simon, Kristina Lorenz, Michaela Matthey, Johannes Breuer, Daniela Wenzel
Pulmonary hypertension is a severe, incurable disease with a poor prognosis. Although treatment regimens have improved during the last 2 decades, current pharmacologic strategies are limited and focus on the modulation of only a few pathways related to endothelin, NO, and prostacyclin signaling. Therefore, the identification of novel molecular targets is urgently needed. We found that the β2 adrenoceptor (AR) agonists terbutaline (TER) and salbutamol induced a dose-dependent vasorelaxation in large pulmonary arteries but not aortas of mouse...
January 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29295852/cyclooxygenase-2-selectively-controls-renal-blood-flow-through-a-novel-ppar%C3%AE-%C3%AE-dependent-vasodilator-pathway
#9
Nicholas S Kirkby, Walkyria Sampaio, Gisele Etelvino, Daniele T Alves, Katie L Anders, Rafael Temponi, Fisnik Shala, Anitha S Nair, Blerina Ahmetaj-Shala, Jing Jiao, Harvey R Herschman, Wang Xiaomeng, Walter Wahli, Robson A Santos, Jane A Mitchell
Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in inflammation and cancer targeted by nonsteroidal anti-inflammatory drugs. COX-2 is also expressed constitutively in discreet locations where its inhibition drives gastrointestinal and cardiovascular/renal side effects. Constitutive COX-2 expression in the kidney regulates renal function and blood flow; however, the global relevance of the kidney versus other tissues to COX-2-dependent blood flow regulation is not known. Here, we used a microsphere deposition technique and pharmacological COX-2 inhibition to map the contribution of COX-2 to regional blood flow in mice and compared this to COX-2 expression patterns using luciferase reporter mice...
January 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29288468/interactions-between-bradykinin-and-plasmin-in-the-endothelial-ca2-response
#10
Yukako Obata, Kazuhiko Takeuchi, Jiazhang Wei, Akio Hakamata, Keiichi Odagiri, Yoshiki Nakajima, Hiroshi Watanabe
Plasmin is a fibrinolytic factor and a serine protease that activates protease-activated receptors (PARs) to produce endothelium-derived relaxing factors such as nitric oxide and prostacyclin. Nitric oxide and prostacyclin production is regulated, at least in part, by the intracellular Ca2+ concentration in various blood vessel types. Bradykinin and plasmin stimulate vascular endothelial cells and work simultaneously in pathophysiological conditions such as thrombosis and inflammation. Here, we explored the interactions between bradykinin and plasmin in the endothelial Ca2+ response using the fluorescent indicator, Fura-2/AM, in primary cultures of porcine aortic endothelial cells (PAECs)...
December 29, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29278909/neuroprotective-effect-of-hydroxytyrosol-in-experimental-diabetic-retinopathy-relationship-with-cardiovascular-biomarkers
#11
José Antonio González-Correa, María Dolores Rodríguez-Pérez, Lucía Márquez-Estrada, Juan Antonio López-Villodres, José Julio Reyes, Guillermo Rodríguez-Gutiérrez, Juan Fernández-Bolaños, José Pedro De La Cruz
The aim of the study was to test the neuroprotective effect of hydroxytyrosol (HT) on experimental diabetic retinopathy. Animals were divided in four groups: 1) control nondiabetic rats, 2) streptozotocin-diabetic rats (DR), 3) DR treated with 1 mg/kg/day p.o. HT, and 4) DR treated with 5 mg/kg/day p.o. HT. Treatment with HT was started 7 days before inducing diabetes and was maintained for 2 months. In the DR group total area occupied by extracellular matrix was increased, area occupied by retinal cells was decreased; both returned to near-control values in DR rats treated with HT...
December 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29277148/prostacyclins-in-cardiac-surgery-coming-of-age
#12
Seema P Deshpande, Michael A Mazzeffi, Erik Strauss, Allison Hollis, Kenichi A Tanaka
Prostacyclin (prostaglandin I2 [PGI2]) is an eicosanoid lipid mediator produced by the endothelial cells. It plays pivotal roles in vascular homeostasis by virtue of its potent vasodilatory and antithrombotic effects. Stable pharmacological analogues of PGI2 are used for treatment of pulmonary hypertension and right ventricular failure. PGI2 dose dependently inhibits platelet activation induced by adenosine-5'-diphosphate, arachidonic acid, collagen, and low-dose thrombin. This property has led to its use as an alternative to direct thrombin inhibitors in patients with type II heparin-induced thrombocytopenia (HIT) undergoing cardiac surgery...
December 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29223256/prostacyclin-therapy-for-pulmonary-arterial-hypertension-evolves-again-with-the-development-of-an-implantable-delivery-system
#13
EDITORIAL
Joel A Wirth, Harold I Palevsky
No abstract text is available yet for this article.
December 2017: Chest
https://www.readbyqxmd.com/read/29203526/caveolin-1-regulates-lipid-droplet-metabolism-in-endothelial-cells-via-autocrine-prostacyclin-stimulated-camp-mediated-lipolysis
#14
Andrew Kuo, Monica Y Lee, Kui Yang, Richard W Gross, William C Sessa
Lipid droplets (LD) are dynamic organelles involved in intracellular lipid metabolism in almost all eukaryotic cells and LD associated proteins tightly regulate their dynamics. One LD coat proteins is caveolin-1 (Cav-1), an essential component for caveolae assembly in highly differentiated cells including adipocytes, smooth muscle cells and endothelial cells (EC). However, the role of Cav-1 in LD dynamics is unclear. Here, we report that EC lacking Cav-1 exhibit impaired LD formation. The decreased LD formation was due to due to enhanced  lipolysis, and not caused by reduced triglyceride synthesis or fatty acid uptake...
December 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29197873/comparative-anti-platelet-profiling-reveals-a-potent-anti-aggregatory-effect-of-cd34-progenitor-cell-derived-late-outgrowth-endothelial-cells-in-vitro
#15
Vasileios G Chantzichristos, Fani Gkrozou, Konstantinos Stellos, Minas E Paschopoulos, Alexandros D Tselepis
BACKGROUND/AIMS: Platelets affect endothelial progenitor cell (EPC) functionality, inducing their differentiation into mature endothelial cells. However, it remains to be established whether EPCs can influence platelet functionality. METHODS: Mononuclear proangiogenic cells (MPCs) and early outgrowth cells (EOCs) were prepared from peripheral blood mononuclear cells, whereas late-outgrowth endothelial cells (OECs) were prepared from cord blood CD34+ cells. The effect of the above cells and their supernatants on washed platelet aggregation was studied...
December 2, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29195500/an-implantable-pump-lenus-pro%C3%A2-in-the-treatment-of-pulmonary-arterial-hypertension-with-intravenous-treprostinil
#16
Marcin Kurzyna, Katarzyna Małaczyńska-Rajpold, Andrzej Koteja, Agnieszka Pawlak, Łukasz Chrzanowski, Michał Furdal, Zbigniew Gąsior, Wojciech Jacheć, Bożena Sobkowicz, Justyna Norwa, Tatiana Mularek-Kubzdela, Adam Torbicki
BACKGROUND: Subcutaneous treprostinil is a prostacyclin analogue used to treat pulmonary arterial hypertension (PAH). Due to local pain it can cause a deterioration of heart related quality of life (HRQoL) or even abandonment of treatment. The aim of this paper was to assess the feasibility of treatment with intravenous treprostinil administered by means of the Lenus Pro® implantable pump. METHODS: This was a retrospective, multi-center study involving 12 patients (8 females) with PAH treated with a subcutaneous infusion of treprostinil with intolerable pain at the infusion site...
December 2, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29193819/efficacy-and-safety-of-selexipag-in-adults-with-raynaud-s-phenomenon-secondary-to-systemic-sclerosis-a-randomized-placebo-controlled-phase-ii-study
#17
RANDOMIZED CONTROLLED TRIAL
Christopher P Denton, Éric Hachulla, Gabriela Riemekasten, Andreas Schwarting, Jean-Marie Frenoux, Aline Frey, Franck-Olivier Le Brun, Ariane L Herrick
OBJECTIVE: To determine the effect of selexipag, an oral, selective IP prostacyclin receptor agonist, on the frequency of attacks of Raynaud's phenomenon (RP) in patients with systemic sclerosis (SSc). METHODS: Patients with SSc-related RP were randomized 1:1 to placebo (n = 38) or selexipag (n = 36) in individualized doses (maximum of 1,600 μg twice daily) during a 3-week titration period. The primary end point was the weekly average number of RP attacks during the study maintenance period, analyzed using a Bayesian approach with a negative binomial model adjusted for baseline number of RP attacks...
December 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29189484/comparison-of-bq123-epoprostenol-and-verapamil-as-vasodilators-during-normothermic-ex-vivo-liver-machine-perfusion
#18
Juan Echeverri, Nicolas Goldaracena, Johan Moritz Kaths, Ivan Linares, Roizar Roizales, Dagmar Kollmann, Matyas Hamar, Peter Urbanellis, Sujani Ganesh, Oyedele A Adeyi, Mahmood Tazari, Markus Selzner, Nazia Selzner
BACKGROUND: The optimal vasodilator to avoid hepatic artery (HA) vasospasm during normothermic ex vivo liver perfusion (NEVLP) is yet to be determined. We compared safety and efficacy of BQ123 (endothelin1 antagonist), Epoprostenol (prostacyclin analogue), and Verapamil (calcium channel antagonist). METHODS: Livers from porcine heart beating donors were perfused for 3 hours and transplanted into recipient pigs. Four groups were compared: Group 1: livers perfused with a dose of 1...
November 20, 2017: Transplantation
https://www.readbyqxmd.com/read/29188763/prothrombotic-state-in-a-patient-with-acute-liver-failure-the-question-of-anticoagulation
#19
Ecaterina Scărlă Tescu, Dana Rodica Tomescu
A 35-year-old male with acute liver failure due to acute hepatitis B virus infection was admitted to the intensive care unit with significant hepatocellular injury, cholestasis, abnormal standard coagulation tests, normal rotational thromboelastometry indices, and without signs of bleeding. He underwent emergency liver transplantation without requiring blood product transfusions or procoagulant treatments. The postoperative course was complicated by deep vein thrombosis and impending hepatic artery thrombosis treated with unfractionated heparin, aspirin, and intravenous prostacyclin...
November 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29181669/inhibitory-effect-of-interferons-on-contractive-activity-of-bovine-mesenteric-lymphatic-vessels-and-nodes
#20
D V Unt, G I Lobov
We studied the effect of IFNα-2b and IFNβ-1a on phasic and tonic contractions of isolated bovine mesenteric lymphatic vessels and nodes. IFNα-2b and IFNβ-1a in concentrations of 250-1000 U/ml produced dose-dependent negative chronotropic and inotropic effects on spontaneous phasic contractions and tonus of lymphatic vessels and nodes. In de-endothelialized lymphatic vessels and nodes, IFNα-2b and IFNβ-1a in the same concentrations had less pronounced inhibitory effect on spontaneous contraction and tonus...
November 27, 2017: Bulletin of Experimental Biology and Medicine
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