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Endothelial Receptor Anatagonists

G Eissner, F Kohlhuber, M Grell, M Ueffing, P Scheurich, A Hieke, G Multhoff, G W Bornkamm, E Holler
In this report, we show that ionizing radiation (IR) at a clinically relevant dose (4 Gy) causes apoptosis in macrovascular and microvascular human endothelial cells. Treatment of irradiated cells with a low dose of bacterial endotoxin (LPS), similar to the levels observed in serum during endotoxemia, enhanced the rate of apoptosis, although LPS alone was unable to induce programmed cell death. The cytokine and endotoxin antagonist interleukin-10 (IL-10) reduced the rate of LPS + IR-induced apoptosis to levels obtained with irradiation alone...
December 1, 1995: Blood
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