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Sodium citrate

Gyeong Bo Kim, Sung Yeon Hwang, Tae Gun Shin, Tae Rim Lee, Won Chul Cha, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong
A 59-year-old man presented to the emergency department with a chief complaint of sore throat after swallowing sodium picosulfate/magnesium citrate powder for bowel preparation, without first dissolving it in water. The initial evaluation showed significant mucosal injury involving the oral cavity, pharynx, and epiglottis. Endotracheal intubation was performed for airway protection in the emergency department, because the mucosal swelling resulted in upper airway compromise. After conservative treatment in the intensive care unit, he underwent tracheostomy because stenosis of the supraglottic and subglottic areas was not relieved...
June 2016: Clin Exp Emerg Med
Rei Unno, Kazumi Taguchi, Atsushi Okada, Ryosuke Ando, Shuzo Hamamoto, Yasue Kubota, Li Zuo, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui
OBJECTIVES: To evaluate the effect of potassium-sodium citrate on the development of computed tomography-detected renal microcalculi into symptomatic stones in calcium stone-forming patients. METHODS: Patients (aged 20-80 years) with history of calcium component stones who visited Nagoya City Hospital, Nagoya, Aichi, Japan, between April 2009 and June 2014 were included. They were retrospectively divided into those who did not receive potassium-sodium citrate (non-citrate group, n = 157) and those who did (citrate group, n = 60)...
October 17, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
Jian Cheng, Wei Zhuang, Nana Li, Chenglun Tang, Hanjie Ying
Low D-ribose production by B. subtilis was resulted from plenty of acid formation as responsible for carbon overflow. An approach of co-feeding glucose and sodium citrate is developed here and proved to be useful for D-ribose production. This strategy is critical because it affects the cell concentration, the productivity of D-ribose and, especially, the formation of by-products such as acetoin, lactate, and acetate. D-ribose production was increased by 59.6% from 71.06 to 113.41 g l(-1) without acid formation via co-feeding of 2...
October 14, 2016: Letters in Applied Microbiology
Feryal Al-Saber, Waleed Aldosari, Mariam Alselaiti, Hesham Khalfan, Ahmed Kaladari, Ghulam Khan, George Harb, Riyadh Rehani, Sizuka Kudo, Aya Koda, Tohru Tanaka, Motowo Nakajima, Abdulla Darwish
Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, single-blind, placebo-controlled, dose escalating pilot clinical trial assessed the safety of 5-ALA with SFC at doses up to 200 mg 5-ALA/229.42 mg SFC per day in patients living in Bahrain with type 2 diabetes mellitus that was uncontrolled despite the use of one or more antidiabetic drugs...
2016: Journal of Diabetes Research
Theodor Voiosu, Alina Tanțău, A Voiosu, Andreea Benguș, Cristina Mocanu, Bianca Smarandache, C Baicuș, Ioana Vișovan, B Mateescu
BACKGROUND: Optimal bowel preparation is one of the most important factors affecting the quality of colonoscopy. Several patient-related factors are known to influence the quality of bowel cleansing but randomized trials in this area are lacking. We aimed to compare an individualized bowel prep strategy based on patient characteristics to a standard preparation regimen. MATERIAL AND METHODS: We conducted an endoscopist-blinded multicenter randomized control-trial...
October 13, 2016: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Eun Young Ze, Chang Hwan Choi, Jeong Wook Kim
Sodium picosulfate/magnesium citrate (SPMC) is a widely used oral bowel cleansing agent considered to be relatively safe. However, partially dissolved or undissolved SPMC powder may cause severe injuries of the esophagus and stomach. We report a very rare case of acute gastric injury without esophageal damage caused by the ingestion of undissolved SPMC powder. A 69-year-old man experienced epigastric pain after swallowing SPMC powder without dissolving it in water in preparation for a screening colonoscopy...
October 12, 2016: Clinical Endoscopy
Xiaolin Jin, Runqiang Yang, Liping Guo, Xinkun Wang, Xiaokun Yan, Zhenxin Gu
The effects of sodium citrate (SC), sodium acetate (SA) and sodium tartrate (ST) spraying on mung bean germination were investigated. Exogenous SC, ST and SA treatments significantly reduced the phytic acid content and increased the antioxidant enzyme activities. In this study, an iTRAQ-based proteomic approach was employed to explore the proteomes of mung bean sprouts, and 81, 101 and 90 differentially expressed proteins were identified in 4-day-old SC-, SA- and ST-treated mung bean sprouts, with 38 proteins present in all samples...
March 1, 2017: Food Chemistry
Jingzi Beiyuan, Daniel C W Tsang, Marjorie Valix, Weihua Zhang, Xin Yang, Yong Sik Ok, Xiang-Dong Li
To enhance extraction of strongly bound metals from oxide minerals and organic matter, this study examined the sequential use of reductants, oxidants, alkaline solvents and organic acids followed by a biodegradable chelating agent (EDDS, [S,S]-ethylene-diamine-disuccinic-acid) in a two-stage soil washing. The soil was contaminated by Cu, Zn, and Pb at an e-waste recycling site in Qingyuan city, China. In addition to extraction efficiency, this study also examined the fate of residual metals (e.g., leachability, bioaccessibility, and distribution) and the soil quality parameters (i...
January 2017: Chemosphere
Roberto M Maciel, Fabiano B Carvalho, Ayodeji A Olabiyi, Roberta Schmatz, Jessié M Gutierres, Naiara Stefanello, Daniela Zanini, Michelle M Rosa, Cinthia M Andrade, Maribel A Rubin, Maria Rosa Schetinger, Vera Maria Morsch, Cristiane C Danesi, Sonia T A Lopes
The present study investigated the protective effect of quercetin (Querc) on memory, anxiety-like behavior and impairment of ectonucleotidases and acetylcholinesterase (AChE) activities in brain of streptozotocin-induced diabetic rats (STZ-diabetes). The type 1 diabetes mellitus was induced by an intraperitoneal injection of 70mg/kg of streptozotocin (STZ), diluted in 0.1M sodium-citrate buffer (pH 4.5). Querc was dissolved in 25% ethanol and administered by gavage at the doses of 5, 25 and 50mg/kg once a day during 40days...
September 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mingyi Zhao, Ping Zhu, Masayuki Fujino, Yoshiaki Nishio, Jimei Chen, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Lingling Zhao, Jian Zhuang, Xiao-Kang Li
BACKGROUND: Hypoxia causes cardiac disease via oxidative stress and mitochondrial dysfunction. 5-Aminolevulinic acid in combination with sodium ferrous citrate (ALA/SFC) has been shown to up-regulate heme oxygenase-1 (HO-1) and decrease macrophage infiltration and renal cell apoptosis in renal ischemia injury mice. However, its underlying mechanism remains largely unknown. The aim of this study was to investigate whether ALA/SFC could protect cardiomyocytes from hypoxia-induced apoptosis by autophagy via HO-1 signaling...
October 28, 2016: Biochemical and Biophysical Research Communications
Christian Schulz, Joachim Müller, Joachim Sauter, Stephan Miehlke, Christoph Schmöcker, Dirk Hartmann, Peter Malfertheiner, Carlos Badiola
BACKGROUND AND AIMS: Split-dose regimens are generally recommended for bowel cleansers. However, other regimens still remain in the summary of product characteristics of some bowel cleansers in Europe. The aim of this study is to compare the efficacy and safety of a split-dose regimen of sodium picosulfate/magnesium citrate (SPMC) with a prior-day schedule (AM/PM). METHODS: Multicenter, randomized (EudraCT no. 2013-001620-20), endoscopist-blinded, parallel study, carried out in subjects 18 years or older undergoing elective colonoscopy...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
Vitor de Salles Painelli, Antonio Herbert Lancha Junior
Sodium citrate (SCit) supplementation has been studied for several years as a strategy to reduce the muscle fatigue induced by H(+) ion accumulation within the skeletal muscle during high-intensity, short-duration exercise. Several investigations have been published on this matter, and appear to indicate that SCit is not effective as an ergogenic aid, despite its ability to increase extracellular buffering capacity. In this short report, we briefly discuss the SCit results previously published in the literature and consider them in light of new and promising findings, which appear to address issues associated with previous study designs...
September 27, 2016: British Journal of Sports Medicine
R Allan Jhagroo, Stephen Y Nakada, Kristina L Penniston
INTRODUCTION: Shared medical appointments (SMAs) have decreased patients' wait time to initial stone clinic appointment, standardized education, and increased exposure to nutrition therapy. We assessed the effectiveness of SMAs in reducing patients' urinary stone risk factors. METHODS: Patients who established care in our stone clinic in a SMA between 3/2012 and 8/2015 were sequentially identified. After eliminating those without follow-up urine collections or whose urinary creatinine excretion between the 2 collections varied by >40%, 113 patients were included (M:F 63:50; 54±15 y; BMI 30...
September 27, 2016: Journal of Endourology
Daisuke Sakota, Tatsuki Fujiwara, Katsuhiro Ouchi, Katsuyuki Kuwana, Hiroyuki Yamazaki, Osamu Maruyama
Continuous optical monitoring of thrombus formation in extracorporeal mechanical circulatory support (EMCS) devices will contribute to safe, long-term EMCS. A clinically applicable optical detector must be able to distinguish among the optical characteristics of oxygen saturation (SaO2 ), hematocrit (Hct), and thrombus formation. In vitro studies of spectral changes at wavelengths from 400 to 900 nm associated with SaO2 , Hct, and thrombus formed around the top pivot bearing of a Gyro C1E3 pump were conducted...
September 2016: Artificial Organs
Matheus M Pereira, Rafaela A P Cruz, Mafalda R Almeida, Álvaro S Lima, João A P Coutinho, Mara G Freire
The ability of aqueous biphasic systems (ABS) composed of polyethylene glycols of different molecular weights (PEG 400, 600 and 1000) and buffered aqueous solutions of potassium citrate/citric acid (pH = 5.0 - 8.0) to selectively extract ovalbumin from egg white was here investigated. Phase diagrams, tie-lines and tie-line lengths were determined at 25ºC and the partitioning of ovalbumin in these systems was then evaluated. Aiming at optimizing the selective extraction of ovalbumin in the studied ABS, factors such as pH, PEG molecular weight and amount of the phase-forming components were initially investigated with pure commercial ovalbumin...
June 2016: Process Biochemistry
Domenico Rendina, Gianpaolo De Filippo, Fernando Gianfrancesco, Riccardo Muscariello, Michele Schiano di Cola, Pasquale Strazzullo, Teresa Esposito
BACKGROUND: Genetic factors play a key role in the pathogenesis of hypocitraturia, a common risk factor for nephrolithiasis. The Na(+)-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the vitamin D/Vitamin D receptor (VDR) biological system. The aim of this case-control study was to evaluate the possible epistatic interaction between VDR (rs731236)and SLC13A2 (rs11567842) allelic variants in the pathogenesis of hypocitraturia...
September 17, 2016: Journal of Nephrology
Sarah R Pigmon, Kara D Weatherman, Nicholas Brehl, Cybil J Nielsen
: The purpose of this research is to evaluate the necessity of using heparin in UltraTag™ RBC kits used for nuclear medicine studies. METHODS: Non-heparinized blood (n = 15) and heparinized blood (n = 15) were added into UltraTag™ RBC kits. The samples were evaluated for macroscopic blood clots and microscopic platelet clumping. Control groups with heparin (n = 15) and control groups without heparin (n = 15) were used to help evaluate the effectiveness of the anticoagulant properties within the UltraTag™ RBC kits (sodium citrate) and to evaluate if that played a role in preventing blood clots/clumps...
September 15, 2016: Journal of Nuclear Medicine Technology
Dana B Loureiro, Mauricio Braia, Diana Romanini, Gisela Tubio
The structure and catalytic activity of xylanase from Thermomyces lanuginosus were studied in different media (containing polyethylene glycol -PEG- or salt) at different temperatures. The aim was to study how the native structure of the enzyme is affected to understand the partitioning behavior of xylanase in PEG/sodium citrate (PEG/NaCit) aqueous two-phase systems. The presence of PEGs of different molar masses slightly altered the native structure of xylanase, although its catalytic activity was not affected...
January 2017: Protein Expression and Purification
Leticia Bequer, Tahiry Gómez, José Luis Molina, Daniel Artiles, Rosa Bermúdez, Sonia Clapés
INTRODUCTION: The use of experimental models is essential to study the pathophysiological mechanisms of diabetes.  OBJECTIVES: To compare in adult Wistar rats the diabetogenic action of streptozotocin according to the moment and route of administration during the neonatal period by evaluating biochemical, metabolic and histological variables.  MATERIALS AND METHODS: Eight groups of neonatal female Wistar rats (n=10) were formed. We evaluated the induction with streptozotocin (100 mg/kg of body weight) on days 2 and 5 after birth, as well as the administration routes (subcutaneous or intraperitoneal)...
2016: Biomédica: Revista del Instituto Nacional de Salud
Azadeh Azadbakht, Mahmoud Roushani, Amir Reza Abbasi, Zohreh Derikvand, Saeid Menati
Herein, gold-coated graphene oxide nanosheets hybrid material (GO/AuNPs) with exceptional physical and chemical properties has been utilized as a novel platform for electrode modification. The synthetic method of GO/AuNPs involves anon-covalent functionalization of exfoliated GO with AuNPs based on the reduction of the Au(III) complex by sodium citrate. The prepared GO/AuNPs hybrid exhibits the dispersion of high density AuNPs which were densely decorated on the large surface area of GO. The GO/AuNPs modified glassy carbon (GC) electrode was employed as a sensing platform to immobilize azodicarboxamide (ACA)...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
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