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https://www.readbyqxmd.com/read/27902652/circulating-antibody-1-and-2-years-after-vaccination-with-the-13-valent-pneumococcal-conjugate-vaccine-in-preterm-compared-with-term-infants
#1
Federico Martinón-Torres, Jacek Wysocki, Kimberly J Center, Hanna Czajka, Ewa Majda-Stanislawska, Felix Omeñaca, Ana Concheiro-Guisan, Francisco Gimenez-Sanchez, Leszek Szenborn, Daniel Blázquez-Gamero, Laura Moreno-Galarraga, Peter C Giardina, Gang Sun, William C Gruber, Daniel A Scott, Alejandra Gurtman
BACKGROUND: Premature infants have lower short-term immune responses to vaccination than term infants, but patterns of antibody persistence in preterm infants over longer periods are not well established. This study assessed the persistence of antibody response to the 13-valent pneumococcal conjugate vaccine (PCV13) in formerly preterm versus term infants. METHODS: In total, 100 preterm and 100 term infants received PCV13 with routine vaccines at ages 2, 3, 4, and 12 months...
November 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27895849/celiac-disease-and-obstetrical-gynecological-contribution
#2
REVIEW
Giovanni Casella, Guido Orfanotti, Loredana Giacomantonio, Camillo Di Bella, Valentina Crisafulli, Vincenzo Villanacci, Vittorio Baldini, Gabrio Bassotti
Celiac disease (CD) shows an increased prevalence in female, particularly during the fertile period. Celiac disease should be researched in infertility, spontaneous and recurrent abortions, delayed menarche, amenorrhea, early menopause, and children with low birth-weight. Celiac disease is still little considered during the evaluation of infertility. Up to 50% of women with untreated CD refer an experience of miscarriage or an unfavorable outcome of pregnancy. Celiac patients taking a normal diet (with gluten) have a shorter reproductive period...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27891191/birth-weight-for-gestational-age-is-associated-with-dna-methylation-at-birth-and-in-childhood
#3
Golareh Agha, Hanine Hajj, Sheryl L Rifas-Shiman, Allan C Just, Marie-France Hivert, Heather H Burris, Xihong Lin, Augusto A Litonjua, Emily Oken, Dawn L DeMeo, Matthew W Gillman, Andrea A Baccarelli
BACKGROUND: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic mechanisms, which orchestrate fetal growth and development, may offer insight on the early programming of health and disease. We investigated whether birth weight-for-gestational is associated with DNA methylation at birth and mid-childhood, measured via the Infinium 450K array...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27886650/the-relationship-between-gestational-age-and-the-severity-of-neonatal-abstinence-syndrome
#4
Kelly S Gibson, Ms Sydney Stark, Deepak Kumar, Jennifer L Bailit
BACKGROUND AND AIMS: The relationship between gestational age at delivery and the severity of neonatal abstinence syndrome (NAS) is poorly understood. Our objective was to compare the length of pharmacotherapy and hospital stay among opioid exposed infants born during the late preterm, early term, full term, and late term periods. DESIGN: Retrospective cohort study of infants affected by NAS SETTING: MetroHealth Medical Center in Cleveland, Ohio, USA: an urban tertiary care hospital serving as the referral center for opioid dependency in pregnancy with a level III neonatal intensive care unit PARTICIPANTS: All deliveries complicated by maternal opioid exposure from January 2000 to October 2014; 403 were eligible to be included (n = 102 Late Preterm, 34-36weeks (LP), n = 158 Early Term, 37-38weeks (ET), n = 122 Full Term, 39-40weeks (FT), n = 21 Late Term, ≥41 weeks (LT))...
November 25, 2016: Addiction
https://www.readbyqxmd.com/read/27875363/pmtct-option-b-does-not-increase-preterm-birth-risk-and-may-prevent-extreme-prematurity-a-retrospective-cohort-study-in-malawi
#5
Maganizo B Chagomerana, William C Miller, Brian W Pence, Mina C Hosseinipour, Irving F Hoffman, Robert J Flick, Hannock Tweya, Soyapi Mumba, Frank Chibwandira, Kimberly A Powers
OBJECTIVE: To estimate preterm birth risk among infants of HIV-infected women in Lilongwe, Malawi according to maternal antiretroviral therapy (ART) status and initiation time under Option B+. DESIGN: Retrospective cohort study of HIV-infected women delivering at ≥27 weeks of gestation, April 2012-November 2015. Among women on ART at delivery, we restricted our analysis to those who initiated ART before 27 weeks of gestation. METHODS: We defined preterm birth as a singleton live birth at ≥27 and <37 weeks of gestation, with births at <32 weeks classified as extremely to very preterm...
November 21, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27871275/rationale-and-design-of-support-a-multi-centre-randomised-controlled-trial-to-compare-three-treatments-cervical-cerclage-cervical-pessary-and-vaginal-progesterone-for-the-prevention-of-preterm-birth-in-women-who-develop-a-short-cervix
#6
Natasha L Hezelgrave, Helena A Watson, Alexandra Ridout, Falak Diab, Paul T Seed, Evonne Chin-Smith, Rachel M Tribe, Andrew H Shennan
BACKGROUND: Clinically, once a woman has been identified as being at risk of spontaneous preterm birth (sPTB) due to a short cervical length, a decision regarding prophylactic treatment must be made. Three interventions have the potential to improve outcomes: cervical cerclage (stitch), vaginal progesterone and cervical pessary. Each has been shown to have similar benefit in reduction of sPTB, but there have been no randomised control trials (RCTs) to compare them. METHODS: This open label multi-centre UK RCT trial, will evaluate whether the three interventions are equally efficacious to prevent premature birth in women who develop a short cervix (<25 mm on transvaginal ultrasound)...
November 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27864302/interpregnancy-interval-following-miscarriage-and-adverse-pregnancy-outcomes-systematic-review-and-meta-analysis
#7
REVIEW
Chrishny Kangatharan, Saffi Labram, Sohinee Bhattacharya
BACKGROUND: A short interpregnancy interval (IPI) following a delivery is believed to be associated with adverse outcomes in the next pregnancy. The optimum IPI following miscarriage is controversial. Based on a single large-scale study in Latin and South America, the World Health Organization recommends delaying pregnancy for 6 months after a miscarriage to achieve optimal outcomes in the next pregnancy. OBJECTIVE AND RATIONALE: Our aim was to determine if a short IPI (<6 months) following miscarriage is associated with adverse outcomes in the next pregnancy...
November 17, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27861463/promoting-healthy-eating-and-active-playtime-by-connecting-to-nature-families-with-preschool-children-evaluation-of-pilot-study-play-grow
#8
Tanja Sobko, Zhenzhen Jia, Matthew Kaplan, Alfred Lee, Chia-Huei Tseng
BackgroundThis pilot project aimed to evaluate the "Play&Grow" program which promotes age-appropriate dietary habits and playtime healthy routines through "connectedness to nature" experiences in Hong Kong families with young children.Method38 pre-schoolers (aged 33.97 ± 9.38 months), mothers and their domestic workers were recruited. The families attended one workshop/week for a 4-month period, consisting of: 1) health topic; 2) food games; 3) nature-related outdoor activities.ResultsFeeding practices, particularly Promoting and Encouragement to eat (PE) and Instrumental Feeding (IF) improved after the intervention (p =...
November 18, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27855152/heart-rate-variability-in-hypoxic-ischemic-encephalopathy-during-therapeutic-hypothermia
#9
Robert M Goulding, Nathan J Stevenson, Deirdre M Murray, Vicki Livingstone, Peter M Filan, Geraldine B Boylan
BACKGROUND: Therapeutic hypothermia (TH) aims to ameliorate further injury in infants with moderate and severe hypoxic ischemic encephalopathy (HIE). We aim to assess the effect of TH on heart rate variability (HRV) in infants with HIE. METHODS: Multi-channel video-electroencephalography (EEG) and electrocardiography were assessed at 6-72h after birth in full-term infants with HIE, recruited prior to (pre-TH group) and following (TH group) the introduction of TH in our neonatal unit...
November 17, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27847471/maternal-caloric-restriction-implemented-during-the-preconceptional-and-pregnancy-period-alters-hypothalamic-and-hippocampal-endocannabinoid-levels-at-birth-and-induces-overweight-and-increased-adiposity-at-adulthood-in-male-rat-offspring
#10
María Teresa Ramírez-López, Mariam Vázquez, Laura Bindila, Ermelinda Lomazzo, Clementine Hofmann, Rosarío Noemí Blanco, Francisco Alén, María Antón, Juan Decara, Rocío Arco, Daniel Ouro, Laura Orio, Juan Suárez, Beat Lutz, Raquel Gómez de Heras, Fernando Rodríguez de Fonseca
Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult male offspring...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27843854/clinical-study-of-fundus-findings-in-pregnancy-induced-hypertension
#11
Rahul Navinchandra Bakhda
BACKGROUND AND OBJECTIVES: To study the role of ophthalmoscopy in pregnancy induced hypertension (PIH) in diagnosis, prognosis, differential diagnosis, line of treatment and effect of treatment. MATERIALS AND METHODS: An observational study in which all the patients for the study are selected from antenatal clinic, antenatal wards and preeclampsia and eclampsia room in Department of Obstetrics and Gynecology, General Ophthalmic Out Patient Department (OPD) in case of ambulatory patients, during the period of Nov...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27836536/doppler-screening-and-predictors-of-adverse-outcomes-in-high-risk-pregnancies-affected-by-tobacco
#12
Alison Stalzer, Dara Seybold, Deena Hossino, Mike Broce, Byron Calhoun
OBJECTIVE: The purpose of this study was to investigate associations between Doppler measurements and adverse outcomes in an obstetric population with high tobacco use. METHODS: This retrospective study included patients with Doppler data (umbilical systolic/diastolic velocity ratios (S/D), uterine S/D, uterine left/right ratio index (RI)). Receiver operator characteristic curve analysis determined cut-off elevated Doppler indices. Stepwise logistic regression was used to predict adverse outcomes...
November 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27824723/a-thirty-year-perspective-of-the-long-term-survival-cd4-percentage-and-social-achievements-of-perinatally-hiv-infected-children-as-a-function-of-their-birth-era
#13
Sharon Vuppula, Donna Tyungu, Aditya Kaul, Sulachni Chandwani, Mona Rigaud, William Borkowsky
BACKGROUND: Pediatric HIV has evolved from a pre-antiretroviral era (pre-1989 or Pre-ART) to an antiretroviral (ART) era (1989-1996) & to a highly active antiretroviral therapy (HAART) era (post-1996). As we have passed the 3rd decade following these individuals, we thought it useful to review clinical, laboratory, & social outcomes. METHODS: A retrospective, cross-sectional study of 399 children infected perinatally. They were divided into Pre-ART, ART & HAART groups...
November 7, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27824595/pre-eclampsia-and-childhood-asthma
#14
Maria C Magnus, Siri E Håberg, Per Magnus, Anders Engeland, Per Nafstad, Øystein Karlstad, Wenche Nystad
Studies of pre-eclampsia and childhood asthma are conflicting, and none have performed a formal mediation analysis of preterm birth.We examined the association between pre-eclampsia and asthma at 7 years using national registries, including all births in Norway from 1999 to 2006 (n=406 907), and a subsample of children in the Norwegian Mother and Child Cohort Study (MoBa) (n=45 028) using log-linear regression. We performed a mediation analysis of preterm birth, and a sibling comparison to evaluate unobserved confounding...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27821643/deprivation-occupational-hazards-and-perinatal-outcomes-in-pregnant-workers
#15
J-B Henrotin, M Vaissière, M Etaix, M Dziurla, A Radauceanu, S Malard, D Lafon
BACKGROUND: Recent global economic difficulties have widened social inequalities, but their impact on pregnant workers is not known. AIMS: To investigate the association between deprivation, exposure to occupational hazards and adverse perinatal outcomes in pregnant workers. METHODS: A cross-sectional study performed in 2014 in French occupational health services. Eligible workers were women who had worked during their pregnancy and had a medical visit by occupational health physicians (OHPs) after delivery and at the time of returning to work...
November 7, 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27818373/gestational-age-at-birth-and-academic-performance-population-based-cohort-study
#16
Kathryn Abel, Hein Heuvelman, Susanne Wicks, Dheeraj Rai, Richard Emsley, Renee Gardner, Christina Dalman
BACKGROUND: Numerous studies suggest pre-term birth is associated with cognitive deficit. However, less is known about cognitive outcomes following post-term birth, or the influence of weight variations within term or post-term populations. We examined associations between gestational age (GA) and school performance, by weight-for-GA, focusing on extremely pre- and post-term births. METHOD: Record linkage study of Swedish children born 1973-94 (n = 2 008 102) with a nested sibling comparison (n = 439 629)...
November 6, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27815669/effect-of-agro-ecological-zone-season-of-birth-and-sex-on-pre-weaning-performance-of-nguni-calves-in-limpopo-province-south-africa
#17
T J Mpofu, M M Ginindza, N A Siwendu, K A Nephawe, B J Mtileni
The study was conducted to determine the effect of agro-ecological zone, season of birth and sex on Nguni calves' pre-weaning performance. Production indices such as birth weight (BW), weaning weight (WW), pre-weaning average daily gain (P-ADG) and pre-weaning gain (P-WG) were assessed in the different agro-ecological zones. Herd records on performance of 826 Nguni calves' from nine Nguni herds representing different agro-ecological zones: arid zone (n = 217); semi-arid zone (n = 296); dry sub-humid zone (n = 118) and humid zone (n = 195) were used for the analysis of pre-weaning calf performance...
November 4, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27814244/combined-effects-of-in-utero-and-adolescent-tobacco-smoke-exposure-on-lung-function-in-c57bl-6j-mice
#18
David Drummond, Mélissa Baravalle-Einaudi, Guillaume Lezmi, Shamila Vibhushan, Marie-Laure Franco-Montoya, Alice Hadchouel, Jorge Boczkowski, Christophe Delacourt
BACKGROUND: Foetal determinants of airway function, such as in utero exposure to maternal cigarette smoke (CS), may create a predisposition to adult airflow obstruction and COPD in adulthood. It has been suggested that active smoking in adolescence and pre-existing airflow obstruction have synergistic deleterious effects. OBJECTIVE: We used a mouse model to investigate whether there is a synergistic effect of exposure to CS in utero and during adolescence on lung function...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27801861/patterns-of-smoking-behaviour-in-low-income-pregnant-women-a-cohort-study-of-differential-effects-on-infant-birth-weight
#19
Catherine Hayes, Morgan Kearney, Helen O'Carroll, Lina Zgaga, Michael Geary, Cecily Kelleher
Maternal smoking accounts for 20%-30% of low birth weight (BW). Second-Hand Smoke (SHS) also negatively affects BW. This cohort study explored the differential effect of smoking patterns during pregnancy on infant BW. Smoking status for 652 self-reported smokers attending public ante-natal clinics was assessed at baseline (V1 first ante-natal visit), 28-32 weeks (V2) and one week after birth (V3). Multivariable generalised linear regression models tested smoking patterns (continuing to smoke, sustained quitting, partial quitting) on BW adjusting for household smoking and other co-variates...
October 29, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27800643/delivery-of-a-growth-restricted-offspring-and-the-association-with-early-onset-impaired-maternal-endothelial-function
#20
Sara L Hillman, Tamara Kubba, David J Williams
BACKGROUND: Women who have had small for gestational age offspring have an increased risk of cardiovascular disease in later life. Endothelial dysfunction is a subclinical sign of early cardiovascular disease. It is unknown whether women who have recently had a pregnancy complicated by fetal growth restriction, in the absence of other maternal and fetal disease, have subclinical endothelial dysfunction. OBJECTIVE: To assess maternal endothelial function six months after a pregnancy complicated by fetal growth restriction...
October 31, 2016: Ultrasound in Obstetrics & Gynecology
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