Ellen C N van Vroonhoven, Lucas W Picavet, Rianne C Scholman, Lyanne J P M Sijbers, Corlinda R E Kievit, Noortje A M van den Dungen, Michal Mokry, Anouk Evers, Robert J Lebbink, Enric Mocholi, Paul J Coffer, Jorg J A Calis, Sebastiaan J Vastert, Jorg van Loosdregt
N6-methyladenosine (m6A) is a RNA modification that can regulate post-transcriptional processes including RNA stability, translation, splicing and nuclear export. In CD4+ lymphocytes, m6A modifications have been demonstrated to play a role in early differentiation processes. The role of m6A in CD4+ T cell activation and effector function remains incompletely understood. To assess the role of m6A in CD4+ T lymphocyte activation and function, we assessed the transcriptome-wide m6A landscape of human primary CD4+ T cells by methylated RNA immunoprecipitation (meRIP) sequencing...
April 24, 2024: Journal of Leukocyte Biology