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Esophageal small cell carcinoma

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https://www.readbyqxmd.com/read/29288243/rho-rock-pathway-regulates-migration-and-invasion-of-esophageal-squamous-cell-carcinoma-by-regulating-caveolin-1
#1
Zhaohui Liu, Jing Yu, Ruinuan Wu, Shengxin Tang, Xiaoman Cai, Guanghua Guo, Suzuan Chen
BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. Caveolin-1 (Cav1) and Rho/ROCK pathway play important roles in tumor metastasis, separately. However, less research was focused on the relationship between Cav1 and Rho/ROCK in ECSS metastasis. Therefore, we investigated the relationship between Cav1 and Rho/ROCK pathway in ESCC metastasis. MATERIAL AND METHODS Cav1 and phosphorylated Cav1 (PY14Cav1) were examined in ESCC and in adjacent and non-tumorous tissues from ESCC patients by immunohistochemistry (IHC)...
December 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29286915/upregulation-of-the-long-noncoding-rna-foxd2-as1-predicts-poor-prognosis-in-esophageal-squamous-cell-carcinoma
#2
Jie Bao, Chenjie Zhou, Jiaqing Zhang, Jiaqiang Mo, Qing Ye, Junming He, Jingfang Diao
BACKGROUND: The long non-coding RNA FOXD2-AS1 is highly expressed in non-small cell lung cancer and promotes malignant progression. However, the role of FOXD2-AS1 in esophageal squamous cell carcinoma (ESCC) is still unclear. OBJECTIVE: In this study, we examined the relationships between the expression level of FOXD2-AS1 and the outcome of ESCC patients. METHODS: Expression of FOXD2-AS1 was evaluated in cancer tissue and adjacent non-tumor tissues samples from 147 ESCC patients who received radical surgical resection using qRT-PCR...
December 15, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29250158/function-of-mir-25-in-the-invasion-and-metastasis-of-esophageal-squamous-carcinoma-cells-and-bioinformatical-analysis-of-the-mir-106b-25-cluster
#3
Meng Wang, Yangyang Ou Yang, Qingtao Jin, Linlin Shang, Jian Zhang
MicroRNAs (miRNAs/miRs) are a class of small, non-coding RNA molecules that serve a key function in carcinogenesis and tumor progression. Recent evidence indicates that miRNAs may act as powerful regulators of migration and invasion. The present study aimed to investigate the effect of miR-25 on the invasion and metastasis of KYSE-150 and EC109 esophageal squamous cell carcinoma (ESCC) cells, and predict the mechanism of this effect by bioinformatically analyzing the miR-106b-25 cluster. In order to alter the expression of miR-25 in the two cell lines, a miR-25 inhibitor or mimic were transfected into the cells, which were then studied via Transwell migration and invasion assays...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29245236/a-unique-tripartite-collision-tumor-of-the-esophagus-a-case-report
#4
Dimitrios Schizas, Adamantios Michalinos, Paraskevi Alexandrou, Demetrios Moris, Evangelia Baliou, Diamantis Tsilimigras, Theodore Throupis, Theodore Liakakos
RATIONALE: We report a unique case of a tripartite esophageal collision tumor consisting of three separate histologic types. PATIENTS CONCERNS: Therapeutic dilemmas on the proper treatment of those rare neoplasms remain unanswered considering both proper surgical therapy and adjuvant therapy. DIAGNOSE: In this paper, we report a unique case of a patient with a tripartite esophageal collision tumor consisting of a small cell carcinoma, an adenocarcinoma of medium differentiation and a signet ring cell carcinoma...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29227748/survival-in-signet-ring-cell-carcinoma-varies-based-on-primary-tumor-location-a-surveillance-epidemiology-and-end-results-database-analysis
#5
San-Gang Wu, Xue-Ting Chen, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, Xiao-Qing Pei, Qin Lin
BACKGROUND: The aim of this study was to investigate the survival of patients with signet ring cell carcinoma (SRCC) based on primary tumor location. METHODS: Patient data were obtained from the Surveillance, Epidemiology, and End Results database (1988-2012) with ≥200 cases per tumor location. Cox regression analysis was used to investigate prognostic factors of cause-specific survival (CSS). RESULTS: We identified 24,171 patients. Of the patients, 63...
December 11, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29216641/znf750-expression-is-a-potential-prognostic-biomarker-in-esophageal-squamous-cell-carcinoma
#6
Ryota Otsuka, Yasunori Akutsu, Haruhito Sakata, Naoyuki Hanari, Kentaro Murakami, Masayuki Kano, Takeshi Toyozumi, Masahiko Takahashi, Yasunori Matsumoto, Nobufumi Sekino, Masaya Yokoyama, Koichiro Okada, Tadashi Shiraishi, Aki Komatsu, Keiko Iida, Hisahiro Matsubara
OBJECTIVE: ZNF750, a transcriptional regulator of epidermal differentiation, has been identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the clinical and prognostic significance of ZNF750 expression and to evaluate the effect of ZNF750 knockdown on cell proliferation, migration, and invasion in ESCC. METHODS: A total of 124 patients with ESCC who underwent curative esophagectomy were evaluated in this study...
December 8, 2017: Oncology
https://www.readbyqxmd.com/read/29211313/comparative-study-of-lung-and-extrapulmonary-poorly-differentiated-neuroendocrine-carcinomas-a-seer-database-analysis-of-162-983-cases
#7
Arvind Dasari, Kathan Mehta, Lauren A Byers, Halfdan Sorbye, James C Yao
BACKGROUND: Extrapulmonary neuroendocrine carcinomas (NECs) are poorly studied and are managed similar to lung NECs, which may not account for differences between the 2 groups of tumors as well as the heterogeneity within extrapulmonary NEC. METHODS: Data from the Surveillance, Epidemiology, and End Results program between 1973 and 2012 were used to estimate the relative percentages of lung NECs and subgroups of extrapulmonary NECs, epidemiological patterns at these sites, and the median and 5-year overall survival rates...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29207103/epigenetic-alterations-of-the-igf2-promoter-and-the-effect-of-mir%C3%A2-483%C3%A2-5p-on-its-target-gene-expression-in-esophageal-squamous-cell-carcinoma
#8
Han Zhang, Xiaowei Shi, Weidong Chang, Yingying Li, Li Wang, Linsong Wang
Esophageal squamous cell carcinoma (ESCC) is one of the most widespread malignancies in China. MicroRNAs (miRNAs/miRs) are endogenous evolutionarily‑conserved small non‑coding RNAs that are able to regulate ESCC formation and deterioration by negatively regulating specific target genes. In the present study, the expression levels of miR‑483‑5p and its associated mRNAs were measured by quantitative polymerase chain reaction (PCR) analysis, and the methylation levels of the insulin‑like growth factor 2 (Igf2) promoter were detected via the methylation‑specific PCR method in serum and tissues from patients with ESCC...
November 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29181149/a-case-of-pneumatosis-intestinalis-during-neoadjuvant-chemotherapy-with-cisplatin-and-5-fluorouracil-for-esophageal-cancer%C3%A2
#9
Keita Kouzu, Hironori Tsujimoto, Shuichi Hiraki, Risa Takahata, Yoshihisa Yaguchi, Isao Kumano, Hiroyuki Horiguchi, Shinsuke Nomura, Ken Nagata, Manabu Harada, Hiromi Nagata, Takao Sugihara, Yusuke Ishibashi, Yujiro Itazaki, Satoshi Tsuchiya, Suefumi Aosasa, Kazuo Hase, Junji Yamamoto, Hideki Ueno
Pneumatosis intestinalis (PI) is a relatively rare disease. A 70-year-old man with stage II squamous cell carcinoma of the middle thoracic esophagus was administered cisplatin plus 5-fluorouracil (CF) therapy as neoadjuvant chemotherapy. On Day 14 of the first course of CF therapy, he complained of acute abdominal pain. Computed tomography (CT) revealed PI of the entire colon and a small air bubble in the mesentery. A colonoscopy revealed that there was no finding suggestive of ischemia. Because there was no sign of peritoneal irritation, conservative treatment was selected...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29170450/interplay-between-notch1-and-notch3-promotes-emt-and-tumor-initiation-in-squamous-cell-carcinoma
#10
Mitsuteru Natsuizaka, Kelly A Whelan, Shingo Kagawa, Koji Tanaka, Veronique Giroux, Prasanna M Chandramouleeswaran, Apple Long, Varun Sahu, Douglas S Darling, Jianwen Que, Yizeng Yang, Jonathan P Katz, E Paul Wileyto, Devraj Basu, Yoshiaki Kita, Shoji Natsugoe, Seiji Naganuma, Andres J Klein-Szanto, J Alan Diehl, Adam J Bass, Kwok-Kin Wong, Anil K Rustgi, Hiroshi Nakagawa
Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activated form of Notch1 promotes xenograft tumor growth when expressed ectopically. Here, we demonstrate that Notch1 activation and epithelial-mesenchymal transition (EMT) are coupled to promote SCC tumor initiation in concert with transforming growth factor (TGF)-β present in the tumor microenvironment...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29140849/endoscopic-submucosal-dissection-for-superficial-proximal-esophageal-neoplasia-is-highly-successful
#11
Yi-Qun Zhang, Tao Chen, Chen Zhang, Quan-Lin Li, Wei-Feng Chen, Li-Qing Yao, Ping-Hong Zhou, Mei-Dong Xu
OBJECTIVE: The aim of this study was to evaluate the outcomes of endoscopic submucosal dissection (ESD) for superficial proximal esophageal neoplasia. SUMMARY OF BACKGROUND DATA: The surgery for a tumor located in proximal esophagus is relatively difficult and leads to a high morbidity and mortality. ESD is a minimally invasive endoscopic treatment of superficial neoplasia of the gastrointestinal tract allowing en block resection with low recurrence rates; however, ESD for superficial proximal esophageal neoplasia is little known...
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29115925/synchronous-occurrence-of-hereditary-gastric-adenocarcinoma-gastrointestinal-stromal-tumor-and-esophageal-small-cell-and-squamous-carcinoma-in-situ-an-extremely-rare-case-report
#12
Huijie Fan, Pei Lu, Li Xu, Yanru Qin, Jing Li
BACKGROUND: Hereditary diffuse gastric carcinoma (HDGC) accounts for 1-3% of all gastric carcinomas. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal (GI) tract but they comprise fewer than 1% of all GI malignancies. Small-cell carcinoma (SmCC) is a rare histological type of esophageal carcinoma, accounting for 0.4% to 2.8% of all esophageal tumors. Co-occurrence of SmCC with esophageal tumors caused by squamous carcinoma is also very uncommon...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29098164/cell-signaling-pathway-in-12-o-tetradecanoylphorbol-13-acetate-induced-lcn2-gene-transcription-in-esophageal-squamous-cell-carcinoma
#13
Lingying Meng, Muting Wang, Zepeng Du, Zhongmin Fang, Bingli Wu, Jianyi Wu, Wenming Xie, Jian Shen, Tianxiang Zhu, XieE Xu, Liandi Liao, Liyan Xu, Enmin Li, Bin Lan
LCN2 is involved in various cellular functions, including transport of small hydrophobic molecules, protection of MMP9 from proteolytic degradation, and regulating innate immunity. LCN2 is elevated in multiple human cancers, frequently being associated with tumor size, stage, and invasiveness. Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRβ) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5' flanking region of the LCN2 promoter...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29059170/spsb3-targets-snail-for-degradation-in-gsk-3%C3%AE-phosphorylation-dependent-manner-and-regulates-metastasis
#14
Y Liu, H Zhou, R Zhu, F Ding, Y Li, X Cao, Z Liu
Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcription factor SNAIL is one of the most important initiators of EMT. Therefore, it is of great significance to understand the regulating mechanism of SNAIL. In this study, we carried out a luciferase-based genome-wide screening using small interfering RNA library against ~200 of E3 ligases and ubiquitin-related genes and identified SOCS box protein SPSB3 as a novel E3 ligase component that targets SNAIL into polyubiquitination and degradation in response to GSK-3β phosphorylation of SNAIL...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29052514/five-fraction-sbrt-for-ultra-central-nsclc-in-field-recurrences-following-high-dose-conventional-radiation
#15
Michael C Repka, Nima Aghdam, Shaan K Kataria, Lloyd Campbell, Simeng Suy, Sean P Collins, Eric Anderson, Jonathan W Lischalk, Brian T Collins
PURPOSE/OBJECTIVE: Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body radiation therapy (SBRT) is a promising modality to achieve reasonable local control, although toxicity remains a concern. MATERIALS/METHODS: Patients previously treated with high-dose CF-EBRT (≥59.4 Gy, ≤3 Gy/fraction) for non-metastatic NSCLC who underwent salvage SBRT for localized ultra-central in-field recurrence were included in this analysis...
October 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28983229/inter-evaluator-heterogeneity-of-clinical-diagnosis-for-locally-advanced-esophageal-squamous-cell-carcinoma
#16
Yasuo Hamamoto, Masanori Nojima, Yu Aoki, Takeshi Suzuki, Kenta Kawasaki, Kenro Hirata, Yasutaka Sukawa, Akira Kasuga, Hirofumi Kawakubo, Hiroya Takeuchi, Koji Murakami, Hiromasa Takaishi, Takanori Kanai, Yuko Kitagawa
BACKGROUND: Identifying clinical resectability of locally advanced esophageal squamous cell carcinoma (ESCC) is important, although inter-evaluator heterogeneity (IEH) could exist, especially in borderline resectable (BLR) cases. To investigate the extent of heterogeneity, we conducted clinical diagnostic imaging questionnaires. MATERIALS AND METHODS: Five cases with clinical T3 or T4 cases, which were treated with neo-adjuvant triplet chemotherapy followed by surgery, were selected as the model...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28903420/high-expression-of-ki-67-is-an-independent-favorable-prognostic-factor-for-esophageal-small-cell-carcinoma
#17
Han-Yu Deng, Zi-Hang Chen, Zhi-Qiang Wang, Yun-Cang Wang, En-Min Li, Li-Yan Xu, Yi-Dan Lin, Long-Qi Chen
BACKGROUND: The prognostic value of Ki-67 expression in small cell carcinoma of the esophagus (SCCE) has not been explored in any previous studies. Therefore, we conducted this retrospective study to investigate the prognostic role of Ki-67 in SCCE for the first time. RESULTS: A total of 44 patients were included for analysis. The baseline clinicopathological data of these SCCE patients shared similar characteristics with previous studies. Ten patients were at stage I, 17 at stage II, and the remaining 17 were at stage III...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28886266/metastasis-of-esophageal-small-cell-carcinoma-to-the-appendix-a-case-report-and-literature-review
#18
Qianrong Wang, Tao Zhou, Hongfu Sun, Baosheng Li
Primary small cell carcinoma (SCC) of the esophagus is characterized by high malignancy with a tendency to metastasize early through lymph and blood circulation. Metastasis of esophageal SCC frequently occurs to distant organs such as liver and lung. However, few cases of appendiceal metastasis have been reported. This paper first presents a pathologically confirmed case with metastasis of esophageal SCC to the appendix. This particular case highlights the importance of pathological diagnosis and provides new evidence of appendiceal metastasis from esophageal SCC...
September 2, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28883282/development-of-immune-checkpoint-inhibitors
#19
Shigehisa Kitano
Immune checkpoint inhibitors are the most striking innovation in the clinical development of immunotherapy. Monoclonal antibodies (mAbs) restore and augment the antitumor immune activities of cytotoxic T cells by mainly blocking immune checkpoint molecules on T cells or their ligands on antigen-presenting and tumor cells. Based on preclinical data, many clinical trials have demonstrated the acceptable safety profiles and efficacies of mAb in various cancers. The A first-in-class approved immune checkpoint inhibitor is ipilimumab, which is a fully humanized mAb that blocks the immunosuppressive signal by cytotoxic T-lymphocyte antigen 4...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28867195/simultaneous-targeting-pi3k-and-perk-pathways-promotes-cell-death-and-improves-the-clinical-prognosis-in-esophageal-squamous-carcinoma
#20
Shao-Qi Wang, Xiao Wang, Kai Zheng, Kai-Sheng Liu, Shao-Xiang Wang, Cong-Hua Xie
PI3K pathway is an important anti-tumor target, but its effect and mechanism is not clear in esophageal squamous cell carcinoma (ESCC). By analysis of the Cancer Genome Atlas (TCGA) datasets, we found that PI3Ks level were significantly upregulated in human esophageal cancer tissues compared with that in non-cancer tissues. The alteration of PI3K can significantly affect the overall patient survival in ESCC but not in esophageal adenocarcinoma (EAC). We found that the classic PI3K inhibitor LY294002 obviously inhibited the canonical mammalian target of rapamycin (mTOR) pathway and restrained the growth of ESCC with less toxicity to normal cells...
November 4, 2017: Biochemical and Biophysical Research Communications
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