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Esophageal small cell carcinoma

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https://www.readbyqxmd.com/read/28903420/high-expression-of-ki-67-is-an-independent-favorable-prognostic-factor-for-esophageal-small-cell-carcinoma
#1
Han-Yu Deng, Zi-Hang Chen, Zhi-Qiang Wang, Yun-Cang Wang, En-Min Li, Li-Yan Xu, Yi-Dan Lin, Long-Qi Chen
BACKGROUND: The prognostic value of Ki-67 expression in small cell carcinoma of the esophagus (SCCE) has not been explored in any previous studies. Therefore, we conducted this retrospective study to investigate the prognostic role of Ki-67 in SCCE for the first time. RESULTS: A total of 44 patients were included for analysis. The baseline clinicopathological data of these SCCE patients shared similar characteristics with previous studies. Ten patients were at stage I, 17 at stage II, and the remaining 17 were at stage III...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28886266/metastasis-of-esophageal-small-cell-carcinoma-to-the-appendix-a-case-report-and-literature-review
#2
Qianrong Wang, Tao Zhou, Hongfu Sun, Baosheng Li
Primary small cell carcinoma (SCC) of the esophagus is characterized by high malignancy with a tendency to metastasize early through lymph and blood circulation. Metastasis of esophageal SCC frequently occurs to distant organs such as liver and lung. However, few cases of appendiceal metastasis have been reported. This paper first presents a pathologically confirmed case with metastasis of esophageal SCC to the appendix. This particular case highlights the importance of pathological diagnosis and provides new evidence of appendiceal metastasis from esophageal SCC...
September 8, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28883282/development-of-immune-checkpoint-inhibitors
#3
Shigehisa Kitano
Immune checkpoint inhibitors are the most striking innovation in the clinical development of immunotherapy. Monoclonal antibodies (mAbs) restore and augment the antitumor immune activities of cytotoxic T cells by mainly blocking immune checkpoint molecules on T cells or their ligands on antigen-presenting and tumor cells. Based on preclinical data, many clinical trials have demonstrated the acceptable safety profiles and efficacies of mAb in various cancers. The A first-in-class approved immune checkpoint inhibitor is ipilimumab, which is a fully humanized mAb that blocks the immunosuppressive signal by cytotoxic T-lymphocyte antigen 4...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28867195/simultaneous-targeting-pi3k-and-perk-pathways-promotes-cell-death-and-improves-the-clinical-prognosis-in-esophageal-squamous-carcinoma
#4
Shao-Qi Wang, Xiao Wang, Kai Zheng, Kai-Sheng Liu, Shao-Xiang Wang, Cong-Hua Xie
PI3K pathway is an important anti-tumor target, but its effect and mechanism is not clear in esophageal squamous cell carcinoma (ESCC). By analysis of the Cancer Genome Atlas (TCGA) datasets, we found that PI3Ks level were significantly upregulated in human esophageal cancer tissues compared with that in non-cancer tissues. The alteration of PI3K can significantly affect the overall patient survival in ESCC but not in esophageal adenocarcinoma (EAC). We found that the classic PI3K inhibitor LY294002 obviously inhibited the canonical mammalian target of rapamycin (mTOR) pathway and restrained the growth of ESCC with less toxicity to normal cells...
August 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28859974/novel-stat1-mutation-disrupts-small-ubiquitin-related-modifier-sumo-conjugation-causing-gain-of-function
#5
Elizabeth P Sampaio, Li Ding, Stacey R Rose, Phillip Cruz, Amy P Hsu, Anuj Kashyap, Lindsey B Rosen, Margery Smelkinson, Tatyana A Tavella, Elise M N Ferre, Meredith K Wierman, Christa S Zerbe, Michail S Lionakis, Steven M Holland
BACKGROUND: Sumoylation is a post-translational reversible modification of cellular proteins by the conjugation of SUMO (small ubiquitin-related modifier) and comprises an important regulator of protein function. OBJECTIVE: To characterize the molecular mechanism of a novel mutation at the SUMO motif on STAT1. METHODS: STAT1 sequencing and functional characterization were performed in transfection experiments using immunoblotting and immunoprecipitation in STAT1-deficient cell lines...
August 28, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28811223/influence-and-mechanism-of-5-aminolevulinic-acid-photodynamic-therapy-on-the-metastasis-of-esophageal-carcinoma
#6
Xiaona Zhang, Longmei Cai, Jingcai He, Xiaoyan Li, Libo Li, Xiaohua Chen, Ping Lan
BACKGROUD: 5-Aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) for the treatment of esophageal cancer was more and more popularly used since it was approved for the treatment of advanced esophageal cancer in 1996. It has been reported to influence the tumor growth and metastasis via a variety of signaling pathways, but its mechanism remains to be further studied. This research studied the effects of ALA-PDT on esophageal carcinoma in vitro and in vivo, discovering its molecular regulating mechanism and the way to enhence the PDT effect...
August 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28807841/racial-disparity-in-gastrointestinal-cancer-risk
#7
REVIEW
Hassan Ashktorab, Sonia S Kupfer, Hassan Brim, John M Carethers
Cancer from the gastrointestinal tract and its associated excretory organs will occur in more than 300,000 Americans in 2017, with colorectal cancer responsible for >40% of that burden; there will be more than 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to the incidence and mortality of these cancers exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in non-Hispanic whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among blacks...
August 12, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28794639/kiaa1522-overexpression-promotes-tumorigenicity-and-metastasis-of-esophageal-cancer-cells-through-potentiating-the-erk-activity
#8
Zhi-Hui Xie, Jing Yu, Li Shang, Yi-Qing Zhu, Jia-Jie Hao, Yan Cai, Xin Xu, Yu Zhang, Ming-Rong Wang
Esophageal squamous cell carcinoma (ESCC) is a highly malignant tumor associated with a poor prognosis, and the molecular mechanisms underlying its formation and progression remain poorly understood. KIAA1522 is upregulated in various tumor tissues, but its function is unknown. Alterations in KIAA1522 expression and its implication in ESCC are currently unclear. In this study, an immunohistochemical analysis of ESCC tissues showed that KIAA1522 was highly expressed in 46% (157/342) of ESCC specimens and that its expression was inversely correlated with the degree of differentiation (P=0...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28778066/inhibition-of-lsd1-epigenetically-attenuates-oral-cancer-growth-and-metastasis
#9
Saqer F Alsaqer, Mustafa M Tashkandi, Vinay K Kartha, Ya-Ting Yang, Yazeed Alkheriji, Andrew Salama, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti, Manish V Bais
Lysine-specific demethylase 1 (LSD1) is a nuclear histone demethylase and a member of the amine oxidase (AO) family. LSD1 is a flavin-containing AO that specifically catalyzes the demethylation of mono- and di-methylated histone H3 lysine 4 through an FAD-dependent oxidative reaction. LSD1 is inappropriately upregulated in lung, liver, brain and esophageal cancers, where it promotes cancer initiation, progression, and metastasis. However, unlike other lysine-specific demethylases, the role and specific targets of LSD1 in oral squamous cell carcinoma (OSCC) pathogenesis remain unknown...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28760781/mir-432-induces-nrf2-stabilization-by-directly-targeting-keap1
#10
Burak Akdemir, Yasuaki Nakajima, Johji Inazawa, Jun Inoue
NF-E2-related factor 2 (NRF2) is a master transcriptional regulator that integrates cellular stress responses and is negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1) at the post-translational level. In human cancers, aberrantly stabilized NRF2, by the mutation of either NRF2 or KEAP1 or by the potential inhibition of autophagy, plays a vital role in tumor growth and chemoresistance through the activation of target genes. MicroRNAs (miRNAs) are endogenous small noncoding RNAs that can negatively regulate gene expression by interfering with translation and/or stability of target transcripts...
July 31, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28753582/high-expression-of-ki-67-is-an-independent-favorable-prognostic-factor-for-esophageal-small-cell-carcinoma
#11
Han-Yu Deng, Zi-Hang Chen, Zhi-Qiang Wang, Yun-Cang Wang, En-Min Li, Li-Yan Xu, Yi-Dan Lin, Long-Qi Chen
BACKGROUND: The prognostic value of Ki-67 expression in small cell carcinoma of the esophagus (SCCE) has not been explored in any previous studies. Therefore, we conducted this retrospective study to investigate the prognostic role of Ki-67 in SCCE for the first time. RESULTS: A total of 44 patients were included for analysis. The baseline clinicopathological data of these SCCE patients shared similar characteristics with previous studies. Ten patients were at stage I, 17 at stage II, and the remaining 17 were at stage III...
July 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28740914/independent-test-of-a-model-to-predict-severe-acute-esophagitis
#12
Ellen X Huang, Clifford G Robinson, Alerson Molotievschi, Jeffrey D Bradley, Joseph O Deasy, Jung Hun Oh
PURPOSE: Treatment planning factors are known to affect the risk of severe acute esophagitis during thoracic radiation therapy. We tested a previously published model to predict the risk of severe acute esophagitis on an independent data set. METHODS AND MATERIALS: The data set consists of data from patients who had recoverable treatment plans and received definitive radiation therapy for non-small cell carcinoma of the lung at a single institution between November 2004 and January 2010...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28681114/predicting-the-correlation-of-ezh2-and-cancer-stem-cell-markers-in-esophageal-squamous-cell-carcinoma
#13
GholamReza Karami Madani, Abolfazl Rad, Mehdi Molavi, Sima Ardalan Khales, Mohammad Reza Abbaszadegan, Mohammad Mahdi Forghanifard
BACKGROUND: Enhancer of zeste homolog 2 (EZH2), a stemness factor, plays roles in regulation of cell differentiation and embryonic development as well as cancer progression. Deregulation of EZH2 in cancers is correlated with tumor cell invasiveness, metastasis, and the patients' poor outcome. However, the mechanistic role of EZH2 in cancer is ambiguous. In this study, we aimed to inhibit the expression of EZH2 in a cancer cell line, and evaluate consequence changes in gene expression pattern...
July 6, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28674214/mcl-1-inhibitor-suppresses-tumor-growth-of-esophageal-squamous-cell-carcinoma-in-a-mouse-model
#14
Jianqing Lin, Deqiang Fu, Yijun Dai, Jianguang Lin, Tianwen Xu
Esophageal squamous cell carcinoma (ESCC) has a high morbidity in China, accounting for 90% of all esophageal carcinoma cases. Hence, identifying drug targets for prevention and treatment of ESCC is essential. Due to its critical role in the regulation of cell apoptosis, Mcl-1 holds great potential as a target for treatment against ESCC. In current study, we used a 4-nitroquinoline-1-oxide (4-NQO)-induced ESCC mouse model of test whether A-1210477, a Mcl-1 small molecular inhibitor, could repress ESCC development...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28659612/regulation-of-spock1-by-dual-strands-of-pre-mir-150-inhibit-cancer-cell-migration-and-invasion-in-esophageal-squamous-cell-carcinoma
#15
Yusaku Osako, Naohiko Seki, Keiichi Koshizuka, Atsushi Okato, Tetsuya Idichi, Takayuki Arai, Itaru Omoto, Ken Sasaki, Yasuto Uchikado, Yoshiaki Kita, Hiroshi Kurahara, Kosei Maemura, Shoji Natsugoe
Analysis of our microRNA (miRNA) expression signatures of human cancers based on RNA sequencing have shown that both strands of pre-miR-150, miR-150-5p (the guide strand) and miR-150-3p (the passenger strand), are significantly reduced in cancer tissues. We have investigated the functional significance of both strands of pre-miR-150 in cancer cells. The aim of this study was to investigate the antitumor function of these miRNAs and how these miRNAs regulated oncogenic targets in esophageal squamous cell carcinoma (ESCC)...
June 29, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28656277/hnf1a%C3%A2-as1-promotes-growth-and-metastasis-of-esophageal-squamous-cell-carcinoma-by-sponging-mir%C3%A2-214-to-upregulate-the-expression-of-sox-4
#16
Guannan Wang, Wugan Zhao, Xianzheng Gao, Dandan Zhang, Ye Li, Yanping Zhang, Wencai Li
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in the world, marked by dysphagia and weight loss, bringing great suffering to patients. HNF1A‑AS1 (HAS1), a long non-coding RNA (lncRNA), has been identified prevalently involved in various human cancers. However, the exact effects and molecular mechanisms of HAS1 in ESCC progression are still elusive. In this study, upregulated expression of HAS1 was detected in ESCC tissues and four human ESCC cell lines (KYSE70, KYSE450, EC109 and EC970) compared with normal tissues and cell lines...
June 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28653878/sirtuin-6-plays-an-oncogenic-role-and-induces-cell-autophagy-in-esophageal-cancer-cells
#17
Nan Huang, Zhiwei Liu, Jiabei Zhu, Zhongqi Cui, Yuguang Li, Yongchun Yu, Fenyong Sun, Qiuhui Pan, Qingyuan Yang
Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1α and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression. However, its expression has recently been reported to be highly elevated in a series of tumors, including prostate cancer, breast cancer, and non-small cell lung cancer, indicating that sirtuin 6 plays dual roles in tumorigenicity in a cell/tumor type-specific manner...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28651500/spry4-it1-a-novel-oncogenic-long-non-coding-rna-in-human-cancers
#18
Jianfa Li, Yincong Chen, Zhicong Chen, Anbang He, Haibiao Xie, Qiaoxiao Zhang, Zhiming Cai, Yuchen Liu, Weiren Huang
Long non-coding RNAs are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that long non-coding RNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. Among numerous long non-coding RNAs, we focus on Sprouty4-Intron 1 (SPRY4-IT1), a well-known long non-coding RNA that is overexpressed in various kinds of tumor tissues and cell lines. Accumulating evidences show that SPRY4-IT1 was dysregulated in various cancers, including melanoma, breast cancer, esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, colon cancer, and hepatocellular carcinoma, and amplification of SPRY4-IT1 was associated with different clinicopathological features of cancer patients...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28640389/efficacy-and-safety-of-recombinant-human-lymphotoxin-%C3%AE-derivative-with-cisplatin-and-fluorouracil-in-patients-with-metastatic-esophageal-squamous-cell-carcinoma-a-randomized-multicenter-open-label-controlled-phase-2b-trial
#19
Feng-Hua Wang, Yun Wang, Guo-Ping Sun, Jian-Hua Chen, Ying-Cheng Lin, Wei Liu, Rong-Sheng Zheng, Jia Chen, He-Long Zhang, Hai-Tao Lan, Jun Qi, Yang-Qing Liu, Yan-Ming Deng, Heng Zhao, Jian-Ping Xiong, Qing Xu, Wen-Qi Jiang, Yu-Hong Li
BACKGROUND: Recombinant human lymphotoxin-α derivative (rhLTα-Da) is a lymphotoxin-α derivative that is missing 27 N-terminal amino acid residues. Previous studies indicated a benefit from the addition of rhLTα-Da to cisplatin-based treatment in patients with metastatic esophageal squamous cell carcinoma. The current study was conducted to evaluate the efficacy and safety of rhLTα-Da plus cisplatin and fluorouracil (PF) in patients with mESCC. METHODS: Patients from 15 centers in China were randomly assigned (1:1:1) to 3 arms (arm A, PF plus 10 μg/m(2) daily rhLTα-Da; arm B, PF plus 20 μg/m(2) daily rhLTα-Da; arm C, PF alone)...
June 22, 2017: Cancer
https://www.readbyqxmd.com/read/28638233/esophageal-carcinoma-originating-in-the-surface-epithelium-with-immunohistochemically-proven-esophageal-gland-duct-differentiation-a-case-report
#20
Hiromi Tamura, Hirotsugu Saiki, Takahiro Amano, Masashi Yamamoto, Shiro Hayashi, Hiroka Ando, Reiko Doi, Tsutomu Nishida, Katsumi Yamamoto, Shiro Adachi
A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with non-neoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed...
June 7, 2017: World Journal of Gastroenterology: WJG
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