Veraprapas Kittipibul, Arun Ganesh, Aubrie Coburn, Brian J Coyne, James Matthew Gray, Jeroen Molinger, Neil Ray, Mihai Podgoreanu, Sharon L McCartney, Negmeldeen Mamoun, Robert Curtis Fitzhugh, Philipp Lurz, Cynthia L Green, Adrian F Hernandez, Manesh R Patel, Marat Fudim
Background Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circulation, supporting evidence is limited. We examined changes in venous capacitance surrogates pre- and post-SNM. Methods and Results This is a prespecified analysis of a prospective, open-label, single-arm interventional study evaluating the effects of percutaneous SNM with ropivacaine in chronic heart failure with elevated filling pressures at rest and with exercise...
July 18, 2023: Journal of the American Heart Association