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https://www.readbyqxmd.com/read/29908485/myeloid-kdm6b-deficiency-results-in-advanced-atherosclerosis
#1
Annette E Neele, Marion J J Gijbels, Saskia van der Velden, Marten A Hoeksema, Marieke C S Boshuizen, Koen H M Prange, Hung-Jen Chen, Jan Van den Bossche, Cindy P P A van Roomen, Annelie Shami, Johannes H M Levels, Jeffrey Kroon, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Menno P J de Winther
BACKGROUND AND AIMS: Atherosclerosis is a lipid-driven chronic inflammatory disorder of the arteries, and monocytes and macrophages play a central role in this process. Within the atherosclerotic lesion, macrophages can scavenge modified lipids and become the so-called foam cells. We previously reported that the epigenetic enzyme Kdm6b (also known as Jmjd3) controls the pro-fibrotic transcriptional profile of peritoneal foam cells. Given the importance of these cells in atherosclerosis, we now studied the effect of myeloid Kdm6b on disease progression...
June 1, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29908129/the-role-of-microrna-181a-in-myocardial-fibrosis-following-myocardial-infarction-in-a-rat-model
#2
Peng Chen, Jialin Pan, Xinming Zhang, Zhewei Shi, Xiangjun Yang
BACKGROUND The role of miR-181a in the development of cardiac disease and in particular, myocardial fibrosis following myocardial infarction (MI) remains unknown. The aim of this study was to explore the role of miR-181a in myocardial fibrosis in a rat model of MI and the expression of TGF-β receptor III (TβRIII). MATERIAL AND METHODS Forty adult male Wistar rats were randomly divided into an MI model group (n=30) and a control group with (n=10). The rat MI model involved ligating the left anterior descending (LAD) coronary artery in the model group; the control group was treated with a sham operation...
June 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29908036/acquired-von-willebrand-syndrome-in-congenital-heart-disease-surgery-results-from-an-observational-case-series
#3
Vanya Icheva, Martina Nowak-Machen, Ulrich Budde, Karl Jaschonek, Felix Neunhoeffer, Matthias Kumpf, Michael Hofbeck, Christian Schlensak, Gesa Wiegand
BACKGROUND: Cardiac surgery of the newborn and infant with complex congenital heart disease (CHD) is associated with a high rate of intraoperative bleeding complications. CHD-related anatomic features such as valve stenoses or patent arterial ducts can lead to enhanced shear stress in blood stream and thus cause acquired von Willebrand syndrome (aVWS). OBJECTIVE: To evaluate the intraoperative incidence and impact of aVWS after cardiopulmonary bypass (CPB) in neonates and infants with complex CHD...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29907965/the-genetic-architecture-of-diet-induced-hepatic-fibrosis-in-mice
#4
Simon T Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C Davis, Calvin Pan, Darwin L Dirks, Clara E Magyar, Samuel W French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos-Pérez, Nahum Méndez-Sánchez, Luis Macías-Kauffer, Paola León-Mimila, Samuel Canizales-Quinteros, Xia Yang, Simon W Beaven, Adriana Huertas-Vazquez, Aldons J Lusis
We report the genetic analysis of a "humanized" hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human APOE*3-Leiden and CETP and fed a "Western" diet were studied on the genetic backgrounds of over 100 inbred mouse strains. The mice developed hepatic inflammation and fibrosis that was highly dependent on genetic background, with vast differences in the degree of fibrosis. Histological analysis showed features characteristic of human NASH, including macrovesicular steatosis, hepatocellular ballooning, inflammatory foci and pericellular collagen deposition...
June 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29907829/multiparametric-magnetic-resonance-imaging-for-quantitation-of-liver-disease-a-two-centre-cross-sectional-observational-study
#5
Natasha McDonald, Peter J Eddowes, James Hodson, Scott I K Semple, Nigel P Davies, Catherine J Kelly, Stella Kin, Miranda Phillips, Amy H Herlihy, Timothy J Kendall, Rachel M Brown, Desley A H Neil, Stefan G Hübscher, Gideon M Hirschfield, Jonathan A Fallowfield
LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907298/the-role-of-exosomes-in-allograft-immunity
#6
REVIEW
Sandhya Bansal, Monal Sharma, Ranjithkumar R, T Mohanakumar
Extracellular vesicles are emerging as potent vehicles of intercellular communication. In this review, we focus on a subclass of extracellular vesicles called exosomes. Previously considered an unimportant catch-all, exosomes have recently been recognized for their role in various diseases and their potential for therapeutic use. We have examined the role of exosomes after human lung transplantation and have delineated the composition of circulating exosomes isolated from lung transplant recipients diagnosed with acute and chronic rejection, primary graft dysfunction, and respiratory viral infection...
June 7, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29906404/collagen-1a1-col1a1-promotes-metastasis-of-breast-cancer-and-is-a-potential-therapeutic-target
#7
Jing Liu, Jia-Xin Shen, Hua-Tao Wu, Xiao-Li Li, Xiao-Fen Wen, Cai-Wen Du, Guo-Jun Zhang
PURPOSE: Extracellular matrix (ECM) is an important component of tumor microenvironment and plays critical roles in cancer development and metastasis, in which collagen is the major structural protein. Collagen type I alpha 1 (COL1A1) is reportedly associated with the development of several human diseases. However, the functions and mechanisms of cellular expression of COL1A1 in breast cancer remain unknown. The purpose of this study is to investigate the cellular expression of COL1A1 in breast cancer cells and patients, and its role in the development and metastasis of breast cancer...
May 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29906222/analysis-of-the-microrna-signature-driving-adaptive-right-ventricular-hypertrophy-in-an-ovine-model-of-congenital-heart-disease
#8
Rebecca Johnson Kameny, Youping He, Terry Zhu, Wenhui Gong, Gary W Raff, Cheryl J Chapin, Sanjeev A Datar, Jason Boehme, Akiko Hata, Jeffrey R Fineman
The right ventricular (RV) response to pulmonary arterial hypertension (PAH) is heterogeneous. Most patients have maladaptive changes with RV dilation and failure while some-especially patients with PAH secondary to congenital heart disease (CHD)-have an adaptive response with hypertrophy and preserved systolic function. Mechanisms for RV adaptation to PAH are unknown despite RV function being a primary determinant of mortality. In our CHD ovine model with fetally-implanted aortopulmonary shunt (shunt lambs), we previously demonstrated an adaptive physiologic RV response to increased afterload with hypertrophy...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29906214/re-investigating-the-basement-membrane-zone-of-psoriatic-epidermal-lesions-is-laminin-511-a-new-player-in-psoriasis-pathogenesis
#9
Aki Natsumi, Koji Sugawara, Makiko Yasumizu, Yukari Mizukami, Shigetoshi Sano, Akimichi Morita, Ralf Paus, Daisuke Tsuruta
Psoriasis is a complex chronic inflammatory skin disease characterized by epidermal thickening on the basis of increased keratinocyte proliferation and insufficient apoptosis. Laminins are important components of the basement membrane (BM) and impact on epidermal keratinocyte growth/apoptosis. Although several laminins are involved in the pathogenesis of psoriasis, it is still controversial about the expression patterns of laminin isoforms and which laminins are important in the development of psoriasis. Because laminin-511 and -332 are key BM components in human skin, and laminin-511 stimulates human hair follicle growth, we asked whether the BM zone in psoriasis shows any laminin-related abnormalities...
June 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29905812/defective-cholesterol-metabolism-in-haematopoietic-stem-cells-promotes-monocyte-driven-atherosclerosis-in-rheumatoid-arthritis
#10
Dragana Dragoljevic, Michael J Kraakman, Prabhakara R Nagareddy, Devi Ngo, Waled Shihata, Helene L Kammoun, Alexandra Whillas, Man Kit Sam Lee, Annas Al-Sharea, Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Mark A Febbraio, Jaye Chin-Dusting, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy
Aim: Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA present with systemic inflammation including raised circulating myeloid cells, but fail to display traditional CV risk-factors, particularly dyslipidaemia. We aimed to explore if increased circulating myeloid cells is associated with impaired atherosclerotic lesion regression or altered progression in RA. Methods and results: Using flow cytometry, we noted prominent monocytosis, neutrophilia, and thrombocytosis in two mouse models of RA...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29905408/ginkgolide-b-exerts-anti-inflammatory-and-chondroprotective-activity-in-lps-induced-chondrocytes
#11
Hejia Hu, Yan Li, Zengfeng Xin, Xiangfeng Zhanga
BACKGROUND: Osteoarthritis (OA) is one of degenerative and chronic diseases of articular joints. Articular cartilage is an avascular tissue, and its primary cellular component is chondrocytes. The main characteristic of OA is non-classic inflammation and cartilage degeneration. Ginkgolide B (GB) is a component of Ginkgo biloba which has diverse bioactivities. OBJECTIVES: The present study uses an in vitro experimental model to detect the underlying anti-inflammatory and chondroprotective effects of GB and provides a new way for future clinical therapy of OA...
June 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29904957/identification-of-gene-expression-profiles-and-key-genes-in-subchondral-bone-of-osteoarthritis-using-weighted-gene-coexpression-network-analysis
#12
Sheng-Min Guo, Jian-Xiong Wang, Jin Li, Fang-Yuan Xu, Quan Wei, Hai-Ming Wang, Hou-Qiang Huang, Si-Lin Zheng, Yu-Jie Xie, Chi Zhang
Osteoarthritis (OA) significantly influences the quality life of people around the world. It is urgent to find an effective way to understand the genetic etiology of OA. We used weighted gene coexpression network analysis (WGCNA) to explore the key genes involved in the subchondral bone pathological process of OA. Fifty gene expression profiles of GSE51588 were downloaded from the Gene Expression Omnibus database. The OA-associated genes and gene ontologies were acquired from JuniorDoc. Weighted gene coexpression network analysis was used to find disease-related networks based on 21756 gene expression correlation coefficients, hub-genes with the highest connectivity in each module were selected, and the correlation between module eigengene and clinical traits was calculated...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29902238/laty136f-knock-in-mouse-model-for-human-igg4-related-disease
#13
Kazunori Yamada, Masahiko Zuka, Kiyoaki Ito, Keishi Mizuguchi, Yasushi Kakuchi, Tamehito Onoe, Yasunori Suzuki, Masakazu Yamagishi, Shozo Izui, Marie Malissen, Bernard Malissen, Mitsuhiro Kawano
BACKGROUND: The adaptor protein Linker for activation of T cell (LAT) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting LAT and including a mutation in which tyrosine 136 is replaced by a phenylalanine (LatY136F) develop lymphoproliferative disorder involving T helper type 2 effector cells capable of triggering a massive polyclonal B cell activation that leads to hypergammaglobulinemia G1 and E and to non-resolving inflammation and autoimmunity...
2018: PloS One
https://www.readbyqxmd.com/read/29901289/-the-role-of-structural-changes-of-the-urinary-bladder-extracellular-matrix-in-the-occurrence-of-different-grades-of-adverse-events-after-radiation-therapy
#14
O S Streltsova, V V Dudenkova, A V Maslennikova, E B Kiseleva, E A Tararova, K E Yunusova, L A Sinyakova
AIM: To investigate the role of structural changes of the urinary bladder extracellular matrix in the occurrence of different grades of adverse events after radiation therapy. MATERIALS AND METHODS: The connective tissue matrix was studied using 126 images obtained from the histological sections of the bladder biopsy specimens of 12 patients classified according to the clinical presentation and the grades of late bladder toxicity according to RTOG/EORTC Late Radiation Morbidity Scoring Scheme...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29901190/curcumin-suppresses-cardiac-fibroblasts-activities-by-regulating-the-proliferation-and-cell-cycle-via-the-inhibition-of-the-p38-mapk-erk-signaling-pathway
#15
Guanhua Fang, Shaoqin Chen, Qiuyu Huang, Liangwan Chen, Dongshan Liao
Cardiac fibrosis is a deleterious effect of many cardiovascular diseases. Previous studies have shown that curcumin has exhibited protective effects on cardiovascular diseases. The aim of the present study was to evaluate the effects of curcumin on the activity of human cardiac fibroblasts (CFs) and to elucidate the underlying mechanisms involved. Human CFs were incubated with or without curcumin (20 µmol/l) and transforming growth factor β1 (TGF‑β1; 10 ng/ml), and the expression of α‑smooth muscle actin (α‑SMA), collagen type Iα (COLA)‑1 and COLA3 was evaluated using reverse transcription‑quantitative polymerase chain reaction and western blot analysis...
June 1, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901170/overexpression-of-mir-140-5p-inhibits-lipopolysaccharide-induced-human-intervertebral-disc-inflammation-and-degeneration-by-downregulating-toll-like-receptor-4
#16
Qiang Zhang, Yiping Weng, Yuqing Jiang, Shujie Zhao, Dong Zhou, Nanwei Xu
Toll-like receptor 4 (TLR4) families are receptors for ligands that initiate extracellular or intracellular signaling, such as lipopolysaccharides (LPS). It has been reported that TLR4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the intervertebral disc (IVD). miR-140-5p (miR-140) is reported to participate in cellular anti-inflammatory processes and target TLR4. In the present study, we investigated the relationship between TLR4 and miR-140 in IVD degeneration...
June 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29900821/urethral-lichen-sclerosus-under-the-microscope-a-survey-of-academic-pathologists
#17
Bradley A Erickson, Brennan A Tesdahl, Maria A Voznesensky, Benjamin N Breyer, Bryan B Voelzke, Nejd F Alsikafi, Alex J Vanni, Joshua A Broghammer, Jill C Buckley, Jeremy B Myers, William O Brant, Lee C Zhao, Thomas G Smith Iii, Brian L Swick, Laila Dahmoush
INTRODUCTION: Given the poor understanding of the pathophysiology of genital lichen sclerosus (GLS) and a lack of accepted definitive diagnostic criteria, we proposed to survey pathologists regarding their understanding of GLS. We hypothesized that significant disagreement about GLS will exist. MATERIALS AND METHODS: All urologists participating in the Trauma and Urologic Reconstruction Network of Surgeons identified genitourinary (GUP) and dermatopathologists (DP) at their respective institutions who were then invited to participate in an online survey regarding their experience with diagnosing GLS, GLS pathophysiology and its relationship to urethral stricture disease...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29899873/biologic-canine-and-human-intervertebral-disc-repair-by-notochordal-cell-derived-matrix-from-bench-towards-bedside
#18
Frances C Bach, Anna R Tellegen, Martijn Beukers, Alberto Miranda-Bedate, Michelle Teunissen, Willem A M de Jong, Stefan A H de Vries, Laura B Creemers, Karin Benz, Björn P Meij, Keita Ito, Marianna A Tryfonidou
The socioeconomic burden of chronic back pain related to intervertebral disc (IVD) disease is high and current treatments are only symptomatic. Minimally invasive strategies that promote biological IVD repair should address this unmet need. Notochordal cells (NCs) are replaced by chondrocyte-like cells (CLCs) during IVD maturation and degeneration. The regenerative potential of NC-secreted substances on CLCs and mesenchymal stromal cells (MSCs) has already been demonstrated. However, identification of these substances remains elusive...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29899023/nedd9-targets-col3a1-to-promote-endothelial-fibrosis-and-pulmonary-arterial-hypertension
#19
Andriy O Samokhin, Thomas Stephens, Bradley M Wertheim, Rui-Sheng Wang, Sara O Vargas, Lai-Ming Yung, Minwei Cao, Marcel Brown, Elena Arons, Paul B Dieffenbach, Jason G Fewell, Majed Matar, Frederick P Bowman, Kathleen J Haley, George A Alba, Stefano M Marino, Rahul Kumar, Ivan O Rosas, Aaron B Waxman, William M Oldham, Dinesh Khanna, Brian B Graham, Sachiko Seo, Vadim N Gladyshev, Paul B Yu, Laura E Fredenburgh, Joseph Loscalzo, Jane A Leopold, Bradley A Maron
Germline mutations involving small mothers against decapentaplegic-transforming growth factor-β (SMAD-TGF-β) signaling are an important but rare cause of pulmonary arterial hypertension (PAH), which is a disease characterized, in part, by vascular fibrosis and hyperaldosteronism (ALDO). We developed and analyzed a fibrosis protein-protein network (fibrosome) in silico, which predicted that the SMAD3 target neural precursor cell expressed developmentally down-regulated 9 (NEDD9) is a critical ALDO-regulated node underpinning pathogenic vascular fibrosis...
June 13, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29897015/a-bone-model-to-study-the-role-of-triggering-receptor-expressed-on-myeloid-cells-2-trem-2
#20
Eleonora Rossi, Eva Mracsko, Adam Papadimitropoulos, Nima Allafi, Dieter Reinhardt, Arne Mehrkens, Ivan Martin, Irene Knuesel, Arnaud Scherberich
Triggering receptor expressed on myeloid cells-2 (TREM-2), a transmembrane receptor expressed by macrophages, microglia and osteoclasts, plays a protective role in late-onset Alzheimer Disease (AD). To validate TREM-2 as a therapeutic target in AD, its potential secondary effect on bone homeostasis should be clarified. However, animal models and monolayer cultures of human cells were shown poorly predictive of TREM-2 function in human. Therefore, this study aimed to engineer a tridimensional in vitro model using human progenitors differentiated into osteoblasts and osteoclasts, recapitulating physiological bone homeostasis...
June 13, 2018: Tissue Engineering. Part C, Methods
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