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Hyponatraemia

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https://www.readbyqxmd.com/read/29120013/primary-polydipsia-in-the-medical-and-psychiatric-patient-characteristics-complications-and-therapy
#1
Clara Sailer, Bettina Winzeler, Mirjam Christ-Crain
Primary polydipsia (PP) has been defined as excessive intake of fluids. However, the pathogenesis of PP remains unexplored. Different theories include a dysfunction in the thirst mechanism, involvement of the hippocampus, stress-reducing behaviour and lesion occurrences in specific areas of the brain. Most studies have been performed in the psychiatric setting, indicating that PP coincides with schizophrenia, anxiety disorder and depression. However, an increasing number of case reports emphasise the incidence of PP in non-psychiatric patients...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29110656/in-patient-tolvaptan-use-in-siadh-care-audit-therapy-observation-and-outcome-analysis
#2
Malik Asif Humayun, Iain C Cranston
BACKGROUND: Indications for use of tolvaptan in SIADH-associated hyponatraemia remain controversial. We audited our local guidelines for Tolvaptan use in this situation to review treatment implications including drug safety, hospital admission episode analysis (episodes of liver toxicity, CNS myelinolysis, sodium-related re-admission rates), morbidity; mortality and underlying aetiologies. METHODS: We report a retrospective case series analysis of on-going treatment outcomes (case-note review) for 31 patients (age 73...
November 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29090271/oral-rehydration-of-malnourished-children-with-diarrhoea-and-dehydration-a-systematic-review
#3
Kirsty A Houston, Jack G Gibb, Kathryn Maitland
Background: Diarrhoea complicates over half of admissions to hospital with severe acute malnutrition (SAM). World Health Organization (WHO) guidelines for the management of dehydration recommend the use of oral rehydration with ReSoMal (an oral rehydration solution (ORS) for SAM), which has lower sodium (45mmols/l) and higher potassium (40mmols/l) content than old WHO ORS. The composition of ReSoMal was designed specifically to address theoretical risks of sodium overload and potential under-treatment of severe hypokalaemia with rehydration using standard ORS...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29079633/hyponatraemia-and-its-prognosis-in-acute-heart-failure-is-related-to-right-ventricular-dysfunction
#4
Heesun Lee, Sang Eun Lee, Chan Soon Park, Jin Joo Park, Ga Yeon Lee, Min-Seok Kim, Jin-Oh Choi, Hyun-Jai Cho, Hae-Young Lee, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Byung-Hee Oh
OBJECTIVES: Hyponatraemia is a well-known predictor of clinical outcomes in heart failure (HF). However, the mechanism remains poorly understood. Previous reports suggest that hyponatraemia is related to right HF. We sought to evaluate the association between right ventricular (RV) dysfunction and hyponatraemia, and the impact of this relationship on the prognosis of patients with acute heart failure (AHF). METHODS: This is a nested case-control study of the Korean Acute Heart Failure registry...
October 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29076217/elevated-serum-creatinine-and-hyponatraemia-as-prognostic-factors-in-canine-acute-pancreatitis
#5
V Marchetti, E Gori, I Lippi, E Luchetti, M L Manca, A Pierini
OBJECTIVE: To evaluate prognostic factors for canine acute pancreatitis (AP) based on clinical and laboratory data that can be easily assessed in veterinary practice. DESIGN: Retrospective study between January 2010 and December 2013. METHODS: The diagnosis of AP was based on clinical signs and an abnormal SNAP® cPL™ test result, concurrently with an ultrasound pattern suggestive of pancreatitis. Dogs were divided into survivors and non-survivors...
November 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29054940/rare-presentation-of-an-old-bug
#6
Hasan Ahmad Hasan Albitar, Alice Gallo de Moraes, Kaiser G Lim
We highlight a rare presentation of Legionella infection in a 77-year-old woman with a clinical diagnosis of giant cell arteritis 2 months prior to presentation. She was started on 60 mg prednisone that was tapered to 10 mg after 4 weeks following her diagnosis. She presented with a 1-month progressive dyspnoea in the absence of any other symptoms. Her exposure history was significant only for a recent trip to Florida where she stayed at a hotel. Initial laboratory workup was significant for hyponatraemia (127 mmol/L)...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28954609/hyponatraemia-and-hypopituitarism-an-easily-missed-entity
#7
Melissa H Lee, Genevieve L Calder, Richard J MacIsaac, Nirupa Sachithanandan
No abstract text is available yet for this article.
September 2, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28944774/renal-physiology-prostaglandins-in-thiazide-induced-hyponatraemia-do-they-hold-water
#8
Ewout J Hoorn, Jack F M Wetzels
No abstract text is available yet for this article.
November 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28936011/escitalopram-induced-siadh-in-an-elderly-female-a-case-study
#9
Sudha Vidyasagar, Karthik Rao, Muralidhar Verma, Aswini Dutt Tripuraneni, Navin Patil, Dipanjan Bhattacharjee
Hyponatraemia is a well-established and potentially, a life-threatening adverse effect of selective serotonin receptor uptake inhibitors (SSRI). However, its occurrence secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) with escitalopram, has been reported extremely sporadically. The reporting of such rare, but life-threatening adverse effects of escitalopram assumes immense significance in light of the fact that SSRIs presently form the mainstay of treatment of depressive disorders...
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28919599/clinico-biochemical-profile-of-women-with-hyperemesis-gravidarum-admitted-in-a-tertiary-hospital
#10
S Kabir, M S Basher, H Akhter, T Latif, S N Akhter, R K Karmoker, S A Shaon, K Ahmed
Hyperemesis gravidarum is the most severe form of nausea and vomiting in pregnancy with poor pregnancy outcome. Hormonal changes, psychological and immunological factors are attributed to the condition. Recently, prevalence of Helicobacter pylori among women with Hyperemesis gravidarum has been revealed. A descriptive, cross-sectional study was carried out at antenatal ward, Department of Obstetrics and Gynaecology, Mymensingh Medical College Hospital, Mymensingh among thirty-six purposively selected patients with Hyperemesis gravidarum to assess the clinic-biochemical profile...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28895577/a-study-of-predictors-for-hyponatraemia-in-patients-with-cervical-spinal-cord-injury
#11
P W Song, F L Dong, C C Feng, Y N Shen, Y Wang, R J Zhang, P Ge, C L Shen
STUDY DESIGN: A retrospective study. OBJECTIVES: The objectives of the study were to investigate the predictors for hyponatraemia in patients with cervical spinal cord injuries (CSCIs) and to define the relationship between magnetic resonance imaging (MRI) scans and hyponatraemia. SETTING: The study was carried out at The First Affiliated Hospital of Anhui Medical University. METHODS: A total of 292 patients with CSCIs were retrospectively reviewed to determine the predictors of hyponatraemia...
September 12, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28892600/the-suspect-siadh
#12
Kristen Tee, Jerry Dang
BACKGROUND: Hyponatraemia is one of the most commonly encountered electrolyte abnormalities in general practice. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an important but under-recognised cause. OBJECTIVE: This article explores the presentation, investigation, diagnosis and management of SIADH. DISCUSSION: SIADH can occur secondary to medications, malignancy, pulmonary disease, or any disorder involving the central nervous system...
September 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28859453/comparison-of-complications-trends-and-costs-in-endoscopic-vs-microscopic-pituitary-surgery-analysis-from-a-us-health-claims-database
#13
Anthony O Asemota, Masaru Ishii, Henry Brem, Gary L Gallia
BACKGROUND: Microsurgical and endoscopic techniques are commonly utilized surgical approaches to pituitary pathologies. There are limited data comparing these 2 procedures. OBJECTIVE: To evaluate postoperative complications, associated costs, and national and regional trends of microscopic and endoscopic techniques in the United States employing a nationwide database. METHODS: The Truven MarketScan database 2010 to 2014 was queried and Current Procedural Terminology codes identified patients that underwent microscopic and/or endoscopic transsphenoidal pituitary surgery...
September 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28856224/an-analysis-of-the-relationship-between-serum-cortisol-and-serum-sodium-in-routine-clinical-patients
#14
Eleanor McLaughlan, Julian H Barth
OBJECTIVES: Adrenal insufficiency is an uncommon cause of hyponatraemia that should not be overlooked due to the severe consequences of an Addisonian crisis. Using the laboratory database of a large teaching hospital, we have explored the relationship between serum sodium and serum cortisol, and have estimated the frequency of hypoadrenalism in severely hyponatraemic patients. DESIGN AND METHODS: Data were gathered over a 23 month period from the Laboratory Information Management System at the Leeds Teaching Hospitals NHS Trust for instances where serum sodium and cortisol had been measured on a single sample...
August 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28851716/continuous-remission-of-renal-cell-carcinoma-with-tumour-thrombus-after-severe-adverse-events-following-short-term-treatment-with-sunitinib
#15
Akira Kazama, Akiyoshi Katagiri, Shoko Ishikawa, Takaki Mizusawa
A 64-year-old Japanese man with renal cell carcinoma (RCC) and tumour thrombus in the inferior vena cava was treated with sunitinib. Two weeks after treatment, he was hospitalised for disturbance of consciousness. Laboratory tests revealed high-grade hypoglycaemia, hyponatraemia, liver dysfunction and thrombocytopaenia with disseminated intravascular coagulation. Sunitinib was discontinued and the patient recovered after a protracted platelet transfusion. At 5 months after treatment, CT revealed that the tumour thrombus had disappeared and other lesions had regressed...
August 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28819949/addison-s-disease-concomitant-with-corticotropin-deficiency-and-pituitary-crh-resistance-a-case-report
#16
Krzysztof C Lewandowski, Katarzyna Malicka, Katarzyna Dąbrowska, Andrzej Lewiński
A 36-year-old woman was found to have a low morning ACTH concentration despite a history of Addison's disease. Past medical history: At the age of 23 years the subject developed Graves's disease, which was treated with radioiodine. At about the same time, she claimed to have two episodes of pancreatitis treated with cholecystectomy. About seven months later she was euthyroid on L-thyroxine (TSH 1.51 mIU/mL) but was admitted with hypotension, hyponatraemia (sodium 109 mmol/L), and low morning cortisol (119 nmol/L)...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28804909/evaluation-of-clinical-laboratory-imaging-findings-and-outcome-in-99-dogs-with-leptospirosis
#17
S Knöpfler, A Mayer-Scholl, E Luge, R Klopfleisch, A D Gruber, K Nöckler, B Kohn
OBJECTIVE: To report clinical, laboratory and diagnostic imaging features and prognostic factors in dogs with leptospirosis from North-East Germany. MATERIALS AND METHODS: Medical records of dogs diagnosed with leptospirosis from 2006 to 2013 were evaluated retrospectively. RESULTS: The study included 99 dogs. At initial presentation, the most common clinical signs were lethargy (96%), anorexia (88%), vomiting (85%), painful abdomen (39%), diarrhoea (38%), oliguria (27%) and tachypnoea (26%)...
August 14, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28803524/endocrinopathies-in-paediatric-onset-neuromyelitis-optica-spectrum-disorder-with-aquaporin-4-aqp4-antibody
#18
Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, Saleel Chandratre, Maria Isabel Leite, Penny Fallon, Angela Vincent, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Jacqueline Palace, Cheryl Hemingway
The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28790043/associations-between-hyponatraemia-volume-depletion-and-the-risk-of-falls-in-us-hospitalised-patients-a-case-control-study
#19
Elizabeth A Fehlberg, Robert J Lucero, Michael T Weaver, Anna M McDaniel, A Michelle Chandler, Phyllis A Richey, Lorraine C Mion, Ronald I Shorr
OBJECTIVE: We aimed to determine if abnormal laboratory values which may indicate volume depletion are associated with increased odds of experiencing a hospital-acquired fall. DESIGN: Matched case-control study. SETTING: Four hospitals located in the Southeast USA. PARTICIPANTS: Data from 699 adult fallers and 1189 matched controls (non-fallers) were collected via chart review from 2005 to 2010. Controls were matched to cases by nursing unit, time of fall and length of stay...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28782208/managing-hyponatraemia-secondary-to-primary-polydipsia-beware-too-rapid-correction-of-hyponatraemia
#20
Emma Boehm, Shanal Kumar, Alison Nankervis, Peter Colman
We describe three cases of severe hyponatraemia in the setting of primary polydipsia that were managed in our centre in 2016. Despite receiving different solute loads, large volume diuresis and rapid correction of serum sodium occurred in all cases. Given the potentially catastrophic consequence of osmotic demyelination, we highlight the judicious use of desmopressin and hypotonic fluid infusion to mitigate sodium overcorrection in this setting.
August 2017: Internal Medicine Journal
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