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Hyponatraemia

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https://www.readbyqxmd.com/read/29756423/persistent-hyponatraemia-following-suspected-krait-envenomation-in-a-5-year-old-sri-lankan-child-a-case-report
#1
I Kankananarachchi, M P Fernando, T Denipitiya, P Navabalasooriyar, N C Kitulwatte
No abstract text is available yet for this article.
March 31, 2018: Ceylon Medical Journal
https://www.readbyqxmd.com/read/29745338/hyponatraemia-associated-with-tramadol-use-a-case-report
#2
Tuck Y Yong, Kareeann S.F. Khow
Hyponatraemia is frequently encountered in clinical practice and common among hospitalized patients. Tramadol is a commonly prescribed analgesia with few adverse effects. However, on rare occasions, tramadol has been found to be associated with hyponatraemia. In two patients described in this report, tramadol use was associated with symptomatic hyponatraemia which required hospitalization. Hyponatraemia were corrected after discontinuation of tramadol. A small number of patients with tramadol-associated hyponatraemia have been reported in the English-language medical literature...
May 8, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29737781/epidemiology-and-prognoses-in-a-medical-intermediate-care-unit
#3
Mona Morland, Rolf Haagensen, Fredrik A Dahl, Jan-Erik Berdal
BACKGROUND: The purpose of medical intermediate care units is the observation and treatment of patients with incipient or manifest organ failure. We wished to obtain data on which conditions result in admission to these units and the prognosis for these patients. MATERIAL AND METHOD: All patients admitted to the medical intermediate care unit at Akershus University Hospital in 2014 were registered prospectively with reason for admission, period of hospitalisation, degree of severity, comorbidity, last place of hospitalisation prior to medical intermediate care and treatment limitations (do-not-resuscitate order and/or do-not-intubate order)...
May 8, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29657106/hyponatraemia-is-independently-associated-with-in-hospital-mortality-in-patients-with-pneumonia
#4
Martin Müller, Joerg C Schefold, Viviane Guignard, Aristomenis K Exadaktylos, Carmen A Pfortmueller
BACKGROUND: Hyponatraemia on hospital admission has been shown to be a risk factor for illness severity in critically ill patients. The aim of the present study was to investigate whether hyponatraemia on emergency department (ED) admission independently influences in-hospital mortality, ICU admission, and/or length of hospitalisation in patients with pneumonia. METHODS: 610 patients (64.4% male, median 66 years) diagnosed with pneumonia were identified by retrospective screening of electronic admission data (06/2011-06/2013)...
April 13, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29602842/hyponatraemia-hyperglycaemia-and-worsening-renal-function-at-first-blood-sample-on-emergency-department-admission-as-predictors-of-in-hospital-death-in-patients-with-dyspnoea-with-suspected-acute-heart-failure-retrospective-observational-analysis-of-the-paradise
#5
Tahar Chouihed, Aurélien Buessler, Adrien Bassand, Deborah Jaeger, Jean Marc Virion, Lionel Nace, Françoise Barbé, Sylvain Salignac, Patrick Rossignol, Faiez Zannad, Nicolas Girerd
OBJECTIVES: To assess the prognostic value of hyponatraemia, hyperglycaemia and impaired estimated glomerular filtration rate (eGFR) in predicting in-hospital death in patients with acute heart failure (AHF) admitted for acute dyspnoea in the emergency department. DESIGN: Retrospective observational study. SETTING: Emergency Department of the University Hospital of Nancy. Data were collected from August 2013 to October 2015. PARTICIPANTS: The analysis included 405 patients with AHF admitted for acute dyspnoea in an emergency department...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29562995/a-study-of-atrial-and-brain-natriuretic-peptides-in-tuberculous-meningitis-and-acute-encephalitis
#6
U K Misra, J Kalita, M Kumar, A Tripathi
OBJECTIVE: To report atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels in patients with tuberculous meningitis (TBM) and acute encephalitis syndrome (AES), and evaluate their relationship with hyponatraemia. METHODS: Consecutive patients with TBM and AES were included in the study. Hyponatraemia was categorised as cerebral salt wasting (CSW), syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and a miscellaneous group based on clinical and laboratory criteria...
April 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29559681/comment-on-correspondence-to-a-study-of-predictors-for-hyponatraemia-in-patients-with-cervical-spinal-cord-injury
#7
Peiwen Song, Cailiang Shen
No abstract text is available yet for this article.
March 20, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29540351/beer-hyponatraemia-and-cardiac-conduction-defects
#8
Simon Mifsud, Emma Louise Schembri, Matthew Mercieca Balbi, Mark Gruppetta, James Clark
The authors report a case of a 68-year-old man who was diagnosed with an irreversible second-degree atrioventricular (AV) Mobitz II 2:1 block temporally associated with profound hyponatraemia. The cause of the hyponatraemia was beer potomania. The co-occurrence of reversible first, second and third-degree heart blocks and hyponatraemia has been described in a few published case reports. However, this case is noteworthy as the AV block persisted, despite correction of serum sodium concentration as opposed to other published cases, which meant that the patient required a permanent pacemaker...
March 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29535486/pre-operative-carbamazepine-induced-hyponatraemia-should-we-accept-a-reset-hypo-osmolar-baseline-and-proceed-with-surgery
#9
Seosamh McCauley, Athinyaa Thiraviaraj
No abstract text is available yet for this article.
May 2017: Ulster Medical Journal
https://www.readbyqxmd.com/read/29535477/hyponatraemia-in-hospitalised-adults-a-guide-for-the-junior-doctor
#10
Joseph Fogarty, Clodagh Loughrey
Hyponatraemia is common and often a source of confusion for junior doctors. It is infrequently dangerous, but when it is, is a medical emergency and requires urgent treatment to avoid life-threatening cerebral oedema. Treatment of acute hyponatraemia is also potentially hazardous; it is therefore important to be able to recognise when urgent management is not indicated, and to investigate appropriately. This paper focuses on these issues, which are most likely to be the cause of consternation for the junior doctor...
May 2017: Ulster Medical Journal
https://www.readbyqxmd.com/read/29527518/management-of-diarrhoeal-dehydration-in-childhood-a-review-for-clinicians-in-developing-countries
#11
REVIEW
Emmanuel Ademola Anigilaje
The survival of a child with severe volume depletion at the emergency department depends on the competency of the first responder to recognize and promptly treat hypovolemic shock. Although the basic principles on fluid and electrolytes therapy have been investigated for decades, the topic remains a challenge, as consensus on clinical management protocol is difficult to reach, and more adverse events are reported from fluid administration than for any other drug. While the old principles proposed by Holliday and Segar, and Finberg have stood the test of time, recent systematic reviews and meta-analyses have highlighted the risk of hyponatraemia, and hyponatraemic encephalopathy in some children treated with hypotonic fluids...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29523609/iatrogenic-water-intoxication-in-a-female-adolescent-with-hypopituitarism
#12
Ana Margarida Monteiro, Olinda Marques, Sofia Martins, Ana Antunes
The authors report a case of a 15-year-old girl with hypopituitarism due to pituitary stalk interruption syndrome diagnosed in the neonatal period. The patient was admitted to the emergency room with impaired consciousness and hypoglycaemia. The day before, she increased her water intake to about 1.5 L to perform a pelvic ultrasound. In the following hours, she developed vomiting and food refusal. Blood analysis revealed hypoglycaemia, hyponatraemia, decreased serum osmolality and normal urinary density. Hyponatraemia and adrenal crisis were managed with a gradual but slow resolution of consciousness and electrolytic balance...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29523608/considering-exercise-associated-hyponatraemia-as-a-continuum
#13
Douglas Lewis, Andrew Blow, Jonathan Tye, Tamara Hew-Butler
Exercise-associated hyponatraemia (EAH) always involves a component of overhydration relative to available exchangeable sodium stores. In the majority of cases, this is purely due to excessive consumption of fluids during exercise. In a lesser number of cases, it is apparent that excessive sodium loss through sweat may play a role by decreasing the amount of acutely available exchangeable sodium. Two cases demonstrating the latter, one in an individual with cystic fibrosis (CF) and another in an endurance athlete without CF, demonstrate how elevated dermal sweat losses may contribute to a relative dilutional EAH along a pathophysiological continuum...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29514833/possible-anti-vgkc-autoimmune-limbic-encephalitis-associated-with-siadh
#14
Nicholas Black, Hazim Hamada
An 80-year-old woman presented with a 5-week history of increasing confusion. Examination was remarkable only for deficits in short-term memory and paranoid thoughts. Blood tests revealed hyponatraemia, and further biochemical testing was consistent with syndrome of inappropriate antidiuretic hormone (SIADH). After an exhaustive diagnostic workup for causes of SIADH, the only abnormal finding was a mildly raised antivoltage-gated potassium channel (VGKC) titre of 185 pmol/L (0-69) consistent with possible anti-VGKC autoimmune limbic encephalitis...
March 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29462726/clinically-diagnosed-mediterranean-spotted-fever-in-malta
#15
Paul Torpiano, David Pace
BACKGROUND: Mediterranean Spotted Fever (MSF) is a tick-borne zoonosis caused by Rickettsia conorii which is endemic in Malta, an island in the South Mediterranean that is a popular tourist destination. Diagnosis is frequently based on clinical manifestations as laboratory results are often limited to a retrospective diagnosis. We describe the clinical presentation, diagnosis and treatment of children <16 years who presented with MSF from 2011 to 2016. METHOD: The demographics, clinical findings, laboratory results, management and outcome of all children hospitalised with suspected MSF based on the presence of fever and an eschar, were retrieved from their case notes...
February 17, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29437746/from-renal-salt-wasting-to-siadh
#16
Tzy Harn Chua, Matin Ly, Senthil Thillainadesan, Katie Wynne
Hyponatraemia is common following major head injury and is associated with significant morbidity and mortality. A 20-year-old man presented with reduced consciousness after head trauma and was found to have a fractured skull base with bilateral frontal contusions. On day 3 of his admission, he developed hyponatraemia with raised urine sodium and osmolality, despite receiving dexamethasone and intravenous fluid therapy. His hyponatraemia worsened after the treatment with fluid restriction and oral salt. He was in negative fluid balance suggesting possible renal salt wasting...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29431483/catastrophic-cerebral-myelinolysis-following-extreme-hyponatraemia
#17
Sophie Chambers, Danielle Donoghue, Natalie Anscomb, Ruth A Griffin, Simon W Dubrey
No abstract text is available yet for this article.
February 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29386213/cisplatin-induced-syndrome-of-inappropriate-antidiuretic-hormone-secretion-siadh-with-life-threatening-hyponatraemia
#18
Aaron C Tan, Gavin M Marx
We present a case of cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with metastatic recurrent urothelial carcinoma. Cisplatin-induced SIADH is an uncommon but potentially life-threatening toxicity. Pharmacogenetic characteristics may result in different toxicity profiles in different populations. With such widespread use of cisplatin in a diverse range of cancers, prompt recognition is crucial to detect and prevent severe neurological sequelae.
January 31, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29370992/nivolumab-with-or-without-ipilimumab-treatment-for-metastatic-sarcoma-alliance-a091401-two-open-label-non-comparative-randomised-phase-2-trials
#19
Sandra P D'Angelo, Michelle R Mahoney, Brian A Van Tine, James Atkins, Mohammed M Milhem, Balkrishna N Jahagirdar, Cristina R Antonescu, Elise Horvath, William D Tap, Gary K Schwartz, Howard Streicher
BACKGROUND: Patients with metastatic sarcoma have limited treatment options. Nivolumab and ipilimumab are monoclonal antibodies targeting PD-1 and CTLA-4, respectively. We investigated the activity and safety of nivolumab alone or in combination with ipilimumab in patients with locally advanced, unresectable, or metastatic sarcoma. METHODS: We did a multicentre, open-label, non-comparative, randomised, phase 2 study that enrolled patients aged 18 years or older and had central pathology confirmation of sarcoma with at least one measurable lesion by Response Evaluation Criteria In Solid Tumors (RECIST) 1...
March 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29363235/e7777-in-japanese-patients-with-relapsed-refractory-peripheral-and-cutaneous-t-cell-lymphoma-a-phase-i-study
#20
MULTICENTER STUDY
Ken Ohmachi, Kiyoshi Ando, Michinori Ogura, Toshiki Uchida, Kensei Tobinai, Dai Maruyama, Masayuki Namiki, Tadashi Nakanishi
E7777, a recombinant cytotoxic fusion protein comprising diphtheria toxin fragments A and B and human interleukin-2, shares an amino acid sequence with denileukin diftitox but has improved purity and an increased percentage of active protein monomer species. A phase I study was carried out to evaluate the tolerability, safety, pharmacokinetics, and antitumor activity of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma. E7777 (6, 12, and expanded 9 μg/kg/day) was given to 13 patients by i...
March 2018: Cancer Science
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