keyword
https://read.qxmd.com/read/38442902/molecular-characterization-of-diffuse-large-b-cell-lymphomas-associated-with-hepatitis-c-virus-infection
#1
JOURNAL ARTICLE
Roberta Sciarra, Michele Merli, Caterina Cristinelli, Marco Lucioni, Silvia Zibellini, Roberta Riboni, Daniela Furlan, Silvia Uccella, Caterina Zerbi, Benedetta Bianchi, Manuel Gotti, Virginia Valeria Ferretti, Chiara Varraso, Sara Fraticelli, Tanja Lazic, Irene Defrancesco, Barbara Mora, Laura Libera, Alessandro Mazzacane, Federico Carpi, Martha Berliner, Giuseppe Neri, Ettore Rizzo, Federica De Paoli, Fausto Sessa, Francesco Passamonti, Marco Paulli, Luca Arcaini
Hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) displays peculiar clinicopathological characteristics, but its molecular landscape is not fully elucidated. In this study, we investigated the clinicopathological and molecular features of 54 patients with HCV-associated DLBCL. The median age was 71 years. An underlying marginal zone lymphoma component was detected in 14.8% of cases. FISH analysis showed rearrangements involving BCL6 in 50.9% of cases, MYC in 11.3% and BCL2 in 3...
March 5, 2024: British Journal of Haematology
https://read.qxmd.com/read/38262378/retrospective-investigation-of-human-papillomavirus-cervical-infection-and-lymphoma-incidence-a-clinical-and-pathological-evaluation
#2
JOURNAL ARTICLE
Barbara Gardella, Mattia Dominoni, Marianna Francesca Pasquali, Manuel Gotti, Sara Fraticelli, Marco Lucioni, Stefania Cesari, Giacomo Fiandrino, Annalisa De Silvestri, Caterina Zerbi, Tanja Lazic, Luca Arcaini, Marco Paulli, Arsenio Spinillo
OBJECTIVE: Human Papillomavirus (HPV) persistence is considered the main risk factor for neoplastic progression, and evidence suggests that regulatory T cells play an important role in the failure of viral elimination. Regulatory T cells may be involved in maintaining a microenvironment favorable for viral persistence and neoplasticity, through a deregulation of the local immune response. The association between altered immune function and the development of chronic infections, cancer (solid and hematological), and autoimmune diseases is documented in the literature...
January 23, 2024: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/38207206/myc-rearrangements-in-hiv-associated-large-b-cell-lymphomas-euromyc-a-european-retrospective-study
#3
JOURNAL ARTICLE
Chiara Pagani, Chiara Rusconi, Alessia Dalla Pria, Emanuele Ravano, Philipp Schommers, Mariana Bastos-Oreiro, Luisa Verga, Guido Gini, Michele Spina, Luca Arcaini, Sara Steffanoni, Davide Dalu, Lara Crucitti, Luisa Lorenzi, Piera Balzarini, Chiara Cattaneo, Lucia Bongiovanni, Andreas Rosenwald, Fabio Facchetti, Mark Bower, Andrés J M Ferreri, Giuseppe Rossi, Alessandra Tucci, Alessandro Re
Large B-cell lymphoma (LBCL) carrying MYC rearrangement, alone or together with BCL2 and/or BCL6 translocations, have shown a poor prognosis when treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in the HIV population. Scanty data are available on the prevalence and prognostic impact of MYC rearrangements in HIV-associated LBCL. We conducted a retrospective study to evaluate the clinical effect of MYC rearrangement in HIV-associated LBCL. We evaluated clinical characteristics, treatment received, and outcome of LBCL in patients with HIV with MYC rearrangement (MYC+) and without MYC rearrangement (MYC-)...
February 27, 2024: Blood Advances
https://read.qxmd.com/read/37939832/germline-mpl-mutations-may-be-a-rare-cause-of-triple-negative-thrombocytosis
#4
JOURNAL ARTICLE
Oscar Borsani, Daniela Pietra, Ilaria Carola Casetti, Daniele Vanni, Giacomo Riccaboni, Silvia Catricalà, Bossi Grazia, Emanuela Boveri, Luca Arcaini, Elisa Rumi
Hereditary thrombocytosis (HT) is a rare inherited disorder with clinical features resembling those of sporadic essential thrombocythemia. This study included 933 patients with persistent isolated thrombocytosis for whom secondary reactive causes were excluded. Of 933 patients screened, 567 were JAK2-mutated, 255 CALR-mutated, 41 MPL-mutated, 2 double-mutated, and 68 were triple-negative. Two patients carried germline non-canonical mutations in exon 10: MPL W515* and MPL V501A. One triple-negative patient carried another germline non-canonical MPL mutation outside exon 10: MPL R102P...
November 7, 2023: Experimental Hematology
https://read.qxmd.com/read/37614953/eosinophilic-dermatosis-of-hematologic-malignancy-in-patients-with-chronic-lymphocytic-leukemia-non-hodgkin-s-b-lymphoma-a-single-center-prospective-clinico-pathological-study
#5
JOURNAL ARTICLE
Andrea Michelerio, Carlo Tomasini, Giacomo Fiandrino, Mara De Amici, Marzia Varettoni, Irene Defrancesco, Chiara Cavalloni, Valeria Brazzelli, Federica Derlino, Marco Paulli, Luca Arcaini, Camilla Vassallo
BACKGROUND: The pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear. OBJECTIVE: To describe the clinical, pathological and immunological findings in a series of oncohematological patients with EDHM. METHODS: An observational prospective cohort study of oncohematological patients receiving a diagnosis of EDHM between April 2017 and December 2018...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37592432/deciphering-molecular-complexity-of-hcv-associated-lymphoproliferation
#6
JOURNAL ARTICLE
Michele Merli, Francesco Passamonti, Luca Arcaini
Recent clinical studies demonstrated the achievement of lymphoma responses in patients with Hepatitis C virus-associated indolent lymphoproliferative disorders (LPD) receiving direct-acting antivirals (DAAs) as their sole treatment. However, the molecular mechanisms underlying LPD responses to DAAs are still poorly understood. In their paper the authors provide new molecular insights on this issue, reporting intraclonal diversification and persistence of B-cell clones in most cases, despite viral eradication and beneficial clinical outcome...
August 17, 2023: British Journal of Haematology
https://read.qxmd.com/read/37519804/editorial-hbv-and-lymphoma
#7
EDITORIAL
Giuseppe Gentile, Luca Arcaini, Guido Antonelli, Maurizio Martelli
No abstract text is available yet for this article.
2023: Frontiers in Oncology
https://read.qxmd.com/read/37376128/pharmacokinetics-of-venetoclax-co-administered-with-posaconazole-in-patients-with-acute-myeloid-leukemia
#8
JOURNAL ARTICLE
Simona De Gregori, Eleonora Gelli, Mara Capone, Giulia Gambini, Elisa Roncoroni, Marianna Rossi, Claudia Patricia Tobar Cabrera, Gianluca Martini, Ludovica Calabretta, Luca Arcaini, Riccardo Albertini, Patrizia Zappasodi
The Food and Drug Administration currently approves the combination of hypomethylating agents (HMA), azacytidine or decitabine with venetoclax (VEN) for acute myeloid leukemia (AML) patients aged more than 75 years and for patients unsuitable for intensive chemotherapy. The risk of fungal infection in the early phase of treatment is not negligible; therefore, posaconazole (PCZ) is commonly administered as primary prophylaxis. A drug-drug interaction between VEN and PCZ is well known, but the trend of serum levels of venetoclax when both drugs are overlapped is not clear...
June 8, 2023: Pharmaceutics
https://read.qxmd.com/read/37345080/clinical-and-histopathological-features-of-an-italian-monocentric-series-of-primary-small-bowel-t-cell-lymphomas
#9
JOURNAL ARTICLE
Marco Lucioni, Sara Fraticelli, Giovanni Santacroce, Arturo Bonometti, Nicola Aronico, Roberta Sciarra, Marco Vincenzo Lenti, Paola Ilaria Bianchi, Giuseppe Neri, Monica Feltri, Benedetto Neri, Giuseppina Ferrario, Roberta Riboni, Gino Roberto Corazza, Alessandro Vanoli, Luca Arcaini, Marco Paulli, Antonio Di Sabatino
The gastrointestinal (GI) tract is the most common extranodal site of occurrence of non-Hodgkin lymphomas. Most GI lymphomas are of B-cell lineage, while T-cell lymphomas are less frequent. The aim of our retrospective study was to depict the clinical-pathological profile of a series of patients affected by intestinal T-cell lymphomas (ITCL) and possibly define hallmarks of these neoplasms. A total of 28 patients were included: 17 enteropathy-associated T-cell lymphomas (EATL), 5 monomorphic epitheliotropic T-cell lymphomas (MEITL), 3 indolent T-cell lymphoproliferative disorders of the gastrointestinal tract (ITCLDGT), and 3 intestinal T-cell lymphomas not otherwise specified (ITCL-NOS)...
May 13, 2023: Cancers
https://read.qxmd.com/read/37317279/gut-microbiota-and-b-cell-receptor-bcr-inhibitors-for-the-treatment-of-chronic-lymphocytic-leukemia-is-biodiversity-correlated-with-clinical-response-or-immune-related-adverse-event-occurrence-a-cross-sectional-study
#10
JOURNAL ARTICLE
Valentina Zuccaro, Greta Petazzoni, Irene Mileto, Marta Corbella, Erika Asperges, Paolo Sacchi, Sara Rattotti, Marzia Varettoni, Irene Defrancesco, Patrizia Cambieri, Fausto Baldanti, Luca Arcaini, Raffaele Bruno
Several studies have strengthened the link between the gut microbiota (GM) and the response to immunotherapy in patients with tumors, highlighting the potential role of GM as a biomarker of response. Targeted therapies including B-cell receptor (BCR) inhibitors (BCRi) represent the newest approach to the treatment of chronic lymphocytic leukemia (CLL); however, not all patients achieve a satisfactory response, and immune-related adverse events (irAEs) can also impact the efficacy. The aim of the study was to compare GM biodiversity in patients with CLL, treated with BCRi for at least 12 months...
May 17, 2023: Microorganisms
https://read.qxmd.com/read/37283569/sars-cov-2-infection-in-patients-with-waldenstr%C3%A3-m-s-macroglobulinemia-a-multicenter-international-cohort-study
#11
JOURNAL ARTICLE
Irene Defrancesco, Virginia Valeria Ferretti, Pierre Morel, Charalampia Kyriakou, Efstathios Kastritis, Ibrahim Tohidi-Esfahani, Alessandra Tedeschi, Christian Buske, Ramón García-Sanz, Josephine M I Vos, Veronica Peri, Gloria Margiotta Casaluci, Angela Ferrari, Francesco Piazza, Rimke Oostvogels, Ester Lovato, Lydia Montes, Luc Matthieu Fornecker, Alexander Grunenberg, Meletios Athanasios Dimopoulos, Constantine S Tam, Shirley D'Sa, Veronique Leblond, Judith Trotman, Francesco Passamonti, Luca Arcaini, Marzia Varettoni
No abstract text is available yet for this article.
June 2023: HemaSphere
https://read.qxmd.com/read/37234822/unmet-clinical-needs-in-the-management-of-idiopathic-multicentric-castleman-disease-a-consensus-based-position-paper-from-an-ad-hoc-expert-panel
#12
JOURNAL ARTICLE
Pier Luigi Zinzani, Marco Paulli, Luca Arcaini, Emanuel Della Torre, Simone Ferrero, Amalia Figuera, Ferdinando Frigeri, Maurizio Martelli, Elena Sabattini, Riccardo Scarpa, Giovanni Barosi
Castleman disease describes a group of heterogeneous clinicopathological disorders now included in the tumor-like lesions with B-cell predominance of the World Health Organization classification. Managing idiopathic multicentric Castleman disease (iMCD) is challenging, because few systematic studies or comparative randomized clinical trials have been conducted. International, consensus evidence-based guidelines for iMCD were published in 2018, but gaps in the therapeutic options for difficult-to-treat patients, who do not respond to siltuximab and other conventional therapies, still exist...
June 2023: HemaSphere
https://read.qxmd.com/read/37175521/t-cells-subsets-in-castleman-disease-analysis-of-28-cases-including-unicentric-multicentric-and-hhv8-related-clinical-forms
#13
JOURNAL ARTICLE
Sara Fraticelli, Marco Lucioni, Giuseppe Neri, Deborah Marchiori, Caterina Cristinelli, Michele Merli, Rodolfo Monaco, Tiziana Borra, Antonio Lazzaro, Silvia Uccella, Luca Arcaini, Marco Paulli
Castleman disease (CD) is a rare lymphoproliferative disorder that includes various clinico-pathological subtypes. According to clinical course, CD is divided into unicentric CD (UCD) and multicentric CD (MCD). MCD is further distinguished based on the etiological driver in herpes virus-8-related MCD (that can occur in the setting of HIV); in MCD associated with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes); and idiopathic MCD (iMCD). The latter can also be divided in iMCD-TAFRO (thrombocytopenia, anasarca, fever, myelofibrosis, organomegaly) and iMCD not otherwise specified...
April 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37058477/candidate-germline-biomarkers-of-lenalidomide-efficacy-in-mantle-cell-lymphoma-the-fil-mcl0208-trial
#14
JOURNAL ARTICLE
Simone Ferrero, Daniele Grimaldi, Elena Arrigoni, Mariapia Pironti, Gian Maria Zaccaria, Beatrice Alessandria, Elisa Genuardi, Gabriele De Luca, Marco Ghislieri, Rita Tavarozzi, Alice Di Rocco, Alessandro Re, Vittorio Stefoni, Federica Cavallo, Carola Boccomini, Monica Balzarotti, Vittorio Ruggero Zilioli, Filipa Moita, Luca Arcaini, Elisa Lucchini, Filippo Ballerini, Andrés J M Ferreri, Benedetta Puccini, Giuseppe A Palumbo, Sara Galimberti, Sergio Cortelazzo, Antonello Di Paolo, Marco Ladetto
In the FIL MCL0208 phase III trial, lenalidomide maintenance (LEN) after transplantation (ASCT) in mantle cell lymphoma (MCL) improved progression-free survival (PFS) vs observation (OBS). The host pharmacogenetic background was analyzed to decipher whether single nucleotide polymorphisms (SNPs) of genes encoding transmembrane transporters, metabolic enzymes, or cell surface receptors might predict drug efficacy. Genotypes were obtained by real-time polymerase chain reaction (RT-PCR) in peripheral blood (PB) germ line DNA...
April 14, 2023: Blood Advances
https://read.qxmd.com/read/37034003/role-of-rituximab-addition-to-first-line-chemotherapy-regimens-in-nodular-lymphocyte-predominant-hodgkin-lymphoma-a-study-by-fondazione-italiana-linfomi
#15
JOURNAL ARTICLE
Manuel Gotti, Roberta Sciarra, Alessandro Pulsoni, Francesco Merli, Stefano Luminari, Caterina Zerbi, Livio Trentin, Alessandro Re, Chiara Rusconi, Simonetta Viviani, Andrea Rossi, Federica Cocito, Barbara Botto, Erika Meli, Antonello Pinto, Irene Dogliotti, Guido Gini, Benedetta Puccini, Francesca Ricci, Luca Nassi, Alberto Fabbri, Anna Marina Liberati, Michele Merli, Andrea Riccardo Filippi, Maurizio Bonfichi, Valentina Zoboli, Germana Tartaglia, Giorgia Annechini, Gianna Maria D'Elia, Ilaria Del Giudice, Isabel Alvarez, Andrea Visentin, Stefano Pravato, Daniela Dalceggio, Chiara Pagani, Silvia Ferrari, Caterina Cristinelli, Tanja Lazic, Virginia Valeria Ferretti, Umberto Ricardi, Luca Arcaini
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare entity whose neoplastic cells retain a B-cell phenotype with expression of CD20. Radiotherapy is recommended for favorable stage IA disease while for other stages guidelines suggest therapeutic strategies similar to those used for classic HL. The role of rituximab, although quite widespread, is not completely elucidated. We retrospectively analyzed baseline characteristics of 308 consecutive patients with NLPHL diagnosed in 19 Italian centers from 2000 to 2018...
April 2023: HemaSphere
https://read.qxmd.com/read/36999122/sars-cov-2-vaccination-and-thrombotic-risk-in-myeloproliferative-neoplasms
#16
JOURNAL ARTICLE
Oscar Borsani, Virginia V Ferretti, Ilaria C Casetti, Daniele Vanni, Chiara Trotti, Daniela Pietra, Annalisa De Silvestri, Luca Arcaini, Elisa Rumi
No abstract text is available yet for this article.
February 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/36733229/biological-features-and-outcome-of-diffuse-large-b-cell-lymphoma-associated-with-hepatitis-c-virus-in-elderly-patients-results-of-the-prospective-elderly-project-by-the-fondazione-italiana-linfomi
#17
JOURNAL ARTICLE
Annalisa Arcari, Valentina Tabanelli, Francesco Merli, Luigi Marcheselli, Michele Merli, Monica Balzarotti, Vittorio Ruggero Zilioli, Alberto Fabbri, Federica Cavallo, Gloria Margiotta Casaluci, Alessandra Tucci, Benedetta Puccini, Elsa Pennese, Alice Di Rocco, Manuela Zanni, Leonardo Flenghi, Guido Gini, Roberto Sartori, Annalisa Chiappella, Sara Veronica Usai, Monica Tani, Dario Marino, Luca Arcaini, Daniele Vallisa, Michele Spina
Up to 10%-15% of diffuse large B-cell lymphoma (DLBCL) are related to hepatitis C virus (HCV) infection, in particular in elderly patients. The Fondazione Italiana Linfomi has recently published a multicentre prospective observational study, the 'Elderly Project', on the outcome of DLBCL in patients aged ≥65 years, evaluated using a simplified comprehensive geriatric assessment. The aim of this study was to compare biological and clinical features of HCV positive (HCV+) with HCV negative (HCV-) cases...
February 2, 2023: British Journal of Haematology
https://read.qxmd.com/read/36653509/romidepsin-choep-followed-by-high-dose-chemotherapy-and-stem-cell-transplantation-in-untreated-peripheral-t-cell-lymphoma-results-of-the-ptcl13-phase-ib-ii-study
#18
JOURNAL ARTICLE
Annalisa Chiappella, Anna Dodero, Andrea Evangelista, Alessandro Re, Lorella Orsucci, Sara Veronica Usai, Claudia Castellino, Vittorio Stefoni, Antonio Pinto, Manuela Zanni, Rosanna Ciancia, Chiara Ghiggi, Francesca Gaia Rossi, Annalisa Arcari, Fiorella Ilariucci, Vittorio Ruggero Zilioli, Leonardo Flenghi, Melania Celli, Stefano Volpetti, Fabio Benedetti, Filippo Ballerini, Gerardo Musuraca, Riccardo Bruna, Caterina Patti, Francesco Leonardi, Luca Arcaini, Massimo Magagnoli, Federica Cavallo, Anisa Bermema, Alessandra Tucci, Carola Boccomini, Giovannino Ciccone, Cristiana Carniti, Stefano Aldo Pileri, Paolo Corradini
The standard treatment for young patients with untreated PTCLs is based on anthracycline containing-regimens followed by high-dose-chemotherapy and stem-cell-transplantation (HDT + SCT), but only 40% of them can be cured. Romidepsin, a histone-deacetylase inhibitor, showed promising activity in relapsed PTCLs; in first line, Romidepsin was added with CHOP. We designed a study combining romidepsin and CHOEP as induction before HDT + auto-SCT in untreated PTCLs (PTCL-NOS, AITL/THF, ALK-ALCL), aged 18-65 years...
January 18, 2023: Leukemia
https://read.qxmd.com/read/36556068/assessing-the-efficacy-of-early-therapies-against-sars-cov-2-in-hematological-patients-a-real-life-study-from-a-covid-19-referral-centre-in-northern-italy
#19
JOURNAL ARTICLE
Marta Colaneri, Teresa Chiara Pieri, Silvia Roda, Alessandra Ricciardi, Manuel Gotti, Jacqueline Ferrari, Luca Arcaini, Sara Rattotti, Antonio Piralla, Federica Giardina, Guglielmo Ferrari, Paolo Sacchi, Valentina Zuccaro, Fausto Baldanti, Raffaele Bruno
Early therapies to prevent severe COVID-19 have an unclear impact on patients with hematological malignancies. The aim of this study was to assess their efficacy in this group of high-risk patients with COVID-19 in preventing hospitalizations and reducing the SARS-CoV-2 shedding. This was a single-center, retrospective, observational study conducted in the Fondazione IRCSS Policlinico San Matteo of Pavia, Northern Italy. We extracted the data of patients with hematologic malignancies and COVID-19 who received and did not receive early COVID-19 treatment between 23 December 2021, and May 2022...
December 15, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36529567/corrigendum-to-marginal-zone-lymphomas-esmo-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up-annals-of-oncology-31-2020-17-29
#20
E Zucca, L Arcaini, C Buske, P W Johnson, M Ponzoni, M Raderer, U Ricardi, A Salar, K Stamatopoulos, C Thieblemont, A Wotherspoon, M Ladetto
No abstract text is available yet for this article.
December 16, 2022: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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