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https://www.readbyqxmd.com/read/29350348/snf472-a-novel-inhibitor-of-vascular-calcification-could-be-administered-during-hemodialysis-to-attain-potentially-therapeutic-phytate-levels
#1
Joan Perelló, M Gómez, M D Ferrer, N Y Rodríguez, C Salcedo, J M Buades, M M Pérez, J V Torregrosa, E Martín, F Maduell
BACKGROUND: Cardiovascular calcification (CVC) is a major concern in hemodialysis (HD) and the loss of endogenous modulators of calcification seems involved in the process. Phytate is an endogenous crystallization inhibitor and its low molecular mass and high water solubility make it potentially dialyzable. SNF472 (the hexasodium salt of phytate) is being developed for the treatment of calciphylaxis and CVC in HD patients. We aimed to verify if phytate is lost during dialysis, and evaluate SNF472's behaviour during dialysis...
January 19, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29333462/assessment-of-ultrasound-radio-guided-occult-lesion-localization-in-non-palpable-breast-lesions
#2
Seyed Ali Alamdaran, Donia Farokh, Ayda Sharifi Haddad, Navid Daghighi, Elaheh Modoodi, Ramin Sadeghi, Mohammad Naser Forghani, Asieh Sadat Fattahi
Objectives: Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasound- and radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29327163/manipulating-the-phytic-acid-content-of-rice-grain-toward-improving-micronutrient-bioavailability
#3
REVIEW
Ishara Perera, Saman Seneweera, Naoki Hirotsu
Myo-inositol hexaphosphate, also known as phytic acid (PA), is the most abundant storage form of phosphorus in seeds. PA acts as a strong chelator of metal cations to form phytate and is considered an anti-nutrient as it reduces the bioavailability of important micronutrients. Although the major nutrient source for more than one-half of the global population, rice is a poor source of essential micronutrients. Therefore, biofortification and reducing the PA content of rice have arisen as new strategies for increasing micronutrient bioavailability in rice...
January 11, 2018: Rice
https://www.readbyqxmd.com/read/29325125/age-phosphorus-and-25-hydroxycholecalciferol-regulate-mrna-expression-of-vitamin-d-receptor-and-sodium-phosphate-cotransporter-in-the-small-intestine-of-broiler-chickens
#4
J C Han, J L Zhang, N Zhang, X Yang, H X Qu, Y Guo, C X Shi, Y F Yan
Four experiments were conducted in this study. Experiment 1 was carried out to examine mRNA expressions of nuclear vitamin D receptor (nVDR), membrane vitamin D receptor (mVDR), and type IIb sodium-phosphate cotransporter (NaPi-IIb) in the small intestine of broiler chickens. Experiments 2, 3, and 4 were implemented to evaluate effects of age, non-phytate phosphorus (NPP), and 25-hydroxycholecalciferol (25-OH-D3) on mRNA expressions of nVDR, mVDR, and NaPi-IIb in the duodenum of chickens. Results showed that mRNA expression levels of nVDR and NaPi-IIb were highest in the duodenum of 21-day-old broilers, lower in the jejunum, and lowest in the ileum...
January 6, 2018: Poultry Science
https://www.readbyqxmd.com/read/29325118/interactive-effects-of-phosphorus-calcium-and-phytase-supplements-on-products-of-phytate-degradation-in-the-digestive-tract-of-broiler-chickens
#5
V Sommerfeld, M Schollenberger, I Kühn, M Rodehutscord
This study aimed to distinguish between the single and interactive effects of phosphorus (P), calcium (Ca), and phytase on products of phytate degradation, including the disappearance of myo-inositol (MI), P, Ca, and amino acids (AA) in different segments of the digestive tract in broiler chickens. Additionally, all dephosphorylation steps from myo-inositol 1,2,3,4,5,6-hexakis (dihydrogen phosphate) (InsP6) to MI were investigated in the digesta of the terminal ileum. Unsexed Ross 308 broiler chickens were allocated to 56 pens with 19 birds per pen, and assigned to one of 8 dietary treatments...
January 6, 2018: Poultry Science
https://www.readbyqxmd.com/read/29321596/high-resolution-31p-nmr-spectroscopy-generates-a-quantitative-evolution-profile-of-phosphorous-translocation-in-germinating-sesame-seed
#6
Honghao Cai, Wei-Gang Chuang, Xiaohong Cui, Ren-Hao Cheng, Kuohsun Chiu, Zhong Chen, Shangwu Ding
Phosphorus metabolism and circulation are essential bio-physicochemical processes during development of a plant and have been extensively studied and known to be affected by temperature, humidity, lighting, hormones etc. However, a quantitative description of how various phosphorous species evolve over time has not been reported. In this work, a combined 31P liquid and solid state NMR spectroscopic methodology is employed, supported by a new extraction scheme and data analysis method, to carry out a quantitative investigation of phosphorous circulation in germinating sesame seeds in dark and under illumination with and without adding a growth hormone...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319136/the-use-of-99mtc-phytate-for-assessment-the-protective-effect-of-vitamin-e-against-hepatotoxicity-induced-by-methotrexat-in-rat
#7
Hossein Amirfakhrian, Seyed Mohammad Abedi, Hossein Sadeghi, Soheil Azizi, Seyed Jalal Hosseinimehr
In this study, we investigated the protective effect of vitamin E against methotrexate (MTX)-induced hepatotoxicity by quantitative liver 99mTc-phytate uptake and liver imaging and to compare its effect with histopathology in rat. Rats were divided into five groups as control, solvent, Vit E (100 mg/kg), MTX (20 mg/kg), Vit E + MTX and. Vit E was intraperitoneally administrated for 17 days before MTX injection and continued for 4 days. 99mTc-phytate was injected through the tail of rats after the drug administration...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29300969/influence-of-phytase-or-myo-inositol-supplements-on-performance-and-phytate-degradation-products-in-the-crop-ileum-and-blood-of-broiler-chickens
#8
V Sommerfeld, S Künzel, M Schollenberger, I Kühn, M Rodehutscord
The objective of this study was to investigate the effects of supplementation with free myo-inositol (MI) or graded levels of phytase on inositol phosphate (InsP) degradation, concentrations of MI in the digestive tract and blood, bone mineralization, and prececal digestibility of amino acids (AA). Ross 308 broiler hatchlings were allocated to 40 pens with 11 birds each and assigned to one of 5 treatments. The birds were fed a starter diet until d 11 and a grower diet from d 11 to d 22. All diets were based on wheat, soybean meal, and corn...
December 29, 2017: Poultry Science
https://www.readbyqxmd.com/read/29240752/effect-of-early-dietary-energy-restriction-and-phosphorus-level-on-subsequent-growth-performance-intestinal-phosphate-transport-and-ampk-activity-in-young-broilers
#9
Zhiqiang Miao, Guixian Zhang, Junzhen Zhang, Jianhui Li, Yu Yang
We aimed to determine the effect of low dietary energy on intestinal phosphate transport and the possible underlying mechanism to explain the long-term effects of early dietary energy restriction and non-phytate phosphorus (NPP). A 2 × 3 factorial experiment, consisting of 2 energy levels and 3 NPP levels, was conducted. Broiler growth performance, intestinal morphology in 0-21 days and 22-35 days, type IIb sodium-phosphate co-transporter (NaPi-IIb) mRNA expression, adenylate purine concentrations in the duodenum, and phosphorylated adenosine monophosphate-activated protein kinase (AMPK-α) activity in 0-21 days were determined...
2017: PloS One
https://www.readbyqxmd.com/read/29223287/abdominal-splenosis-usefulness-of-99mtc-phytate-hepato-splenic-scintigraphy-in-the-differential-diagnosis-with-tumor-implantation
#10
Elena Espinosa Muñoz, Ana María Martín García, Diego Ramírez Ocaña, Carmen Puentes Zarzuela
No abstract text is available yet for this article.
December 6, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29216370/the-role-of-arabidopsis-inositol-polyphosphate-kinase-atipk2%C3%AE-in-glucose-suppression-of-seed-germination-and-seedling-development
#11
Qiaofeng Yang, Sihong Sang, Yao Chen, Zhaoyun Wei, Peng Wang
Seed germination and subsequent seedling development are critical phases in plant. These processes are regulated by a complex molecular network in which sugar has been reported to play an essential role. However, factors affecting sugar responses remain to be fully elucidated. In this study, we demonstrate that AtIPK2β, known to participate in the synthesis of myo-inositol 1,2,3,4,5,6-hexakisphosphate (IP6, phytate), affects Arabidopsis responses to glucose during seed germination. Loss-of-function mutant atipk2β showed increased sensitivity to 6% glucose and paclobutrazol (PAC)...
December 4, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29211905/effect-of-different-concentrations-of-dietary-p-and-ca-on-plasma-inorganic-p-and-urinary-p-excretion-using-noncolostomized-and-colostomized-broilers
#12
Megharaja K Manangi, Pramir Maharjan, Craig N Coon
Two 5-d bioassays were conducted to explore the P physiological threshold in broilers based on plasma inorganic P (iP), urinary P and Ca, and excreta P and Ca measurements in non-colostomized and colostomized broilers fed with different concentrations of non-phytate P (NPP) and Ca. In Experiment 1, 80 40-day-old Cobb 500 non-colostomized male broilers were assorted into 8 groups consisting of 10 broilers each and placed in individual metabolic cages. Similarly, 8 colostomized broilers of same age were allotted to 8 individual metabolic cages...
December 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/29198231/effects-of-dietary-calcium-and-phosphorus-deficiency-and-subsequent-recovery-on-broiler-chicken-growth-performance-and-bone-characteristics
#13
A S Valable, A Narcy, M J Duclos, C Pomar, G Page, Z Nasir, M Magnin, M P Létourneau-Montminy
The ability of birds to modify dietary phosphorus utilisation when fed with low-phosphorus and calcium (Ca) diets was studied using different sequences of dietary phosphorus and Ca restriction (depletion) and recovery (repletion) during the grower and the finisher phases. A total of 3600 Ross 708 broilers were randomly divided into 10 replicate pens per treatment (60 per pen, six pens per block). Chicks were fed a common starter diet from days 0 to 10, then a grower control diet (C: 0.90% Ca, 0.39% non-phytate phosphorus, nPP), mid-level diet (M: 0...
December 4, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29194015/phytase-from-citrobacter-koseri-pm-7-enhanced-production-using-statistical-method-and-application-in-ameliorating-mineral-bioaccessibility-and-protein-digestibility-of-high-phytate-food
#14
Preeti Tripathi, Jyothi Lakshmi A, Mukesh Kapoor
The present study was aimed at enhancing phytase (Phy-Ck) production from Citrobacter koseri PM-7 using response surface methodology (RSM) and improving the bioaccessibility of minerals (Fe and Zn) and protein digestibility in high-phytate food using Phy-Ck. A five-variable and three-level central composite design of RSM using wheat bran (6.681% w/v), inoculum level (2.5% v/v), and triton-x-100 (0.2% v/v) resulted in up to 5.57-fold (1.047 U/ml) improvement in Phy-Ck yield from C. koseri PM-7 when compared with fermentation media I & II...
December 1, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29184876/feasibility-of-sentinel-lymph-node-dissection-using-tc-99m-phytate-in-papillary-thyroid-carcinoma
#15
Se Hyun Paek, Ka Hee Yi, Su-Jin Kim, June Young Choi, Kyu Eun Lee, Young Joo Park, Do-Joon Park, Keon Wook Kang, June-Key Chung
Purpose: Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC). Methods: Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed...
November 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29174030/position-paper-on-vegetarian-diets-from-the-working-group-of-the-italian-society-of-human-nutrition
#16
C Agnoli, L Baroni, I Bertini, S Ciappellano, A Fabbri, M Papa, N Pellegrini, R Sbarbati, M L Scarino, V Siani, S Sieri
BACKGROUND: Interest in vegetarian diets is growing in Italy and elsewhere, as government agencies and health/nutrition organizations are emphasizing that regular consumption of plant foods may provide health benefits and help prevent certain diseases. METHODS AND RESULTS: We conducted a Pubmed search, up to September, 2015, for studies on key nutrients (proteins, vitamin B12, iron, zinc, calcium, vitamin D, and n-3 fatty acids) in vegetarian diets. From 295 eligible publications the following emerged: Vegetarians should be encouraged to supplement their diets with a reliable source of vitamin B12 (vitamin-fortified foods or supplements)...
October 31, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29145111/a-novel-protein-tyrosine-phosphatase-like-phytase-from-lactobacillus-fermentum-nkn51-cloning-characterization-and-application-in-mineral-release-for-food-technology-applications
#17
Rekha Sharma, Piyush Kumar, Vandana Kaushal, Rahul Das, Naveen Kumar Navani
A novel protein tyrosine phosphatase like phytase (PTPLP), designated as PhyLf from probiotic bacterium Lactobacillus fermentum NKN51 was identified, cloned, expressed and characterized. The recombinant PhyLf showed specific activity of 174.5 U/mg. PhyLf exhibited strict specificity towards phytate and optimum temperature at 60 °C, pH 5.0 and ionic strength of 100 mM. Km and Kcat of PhyLf for phytate were 0.773 mM and 84.31 s(-1), respectively. PhyLf exhibited high resistance against oxidative inactivation...
November 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29123461/intestinal-absorption-and-factors-influencing-bioavailability-of-magnesium-an-update
#18
REVIEW
Jan Philipp Schuchardt, Andreas Hahn
Background: Information on the bioavailability of the essential mineral Mg2+ is sparse. Objective/Method: Evaluation of the present knowledge on factors influencing the bioavailability and intestinal absorption of Mg2+. Results: Mg2+ is absorbed via a paracellular passive and a transcellular active pathway that involves TRPM6/7 channel proteins. The bioavailability of Mg2+ varies within a broad range, depending on the dose, the food matrix, and enhancing and inhibiting factors...
November 2017: Current Nutrition and Food Science
https://www.readbyqxmd.com/read/29112750/high-stocking-density-alters-bone-related-calcium-and-phosphorus-metabolism-by-changing-intestinal-absorption-in-broiler-chickens
#19
Z W Sun, Q H Fan, X X Wang, Y M Guo, H J Wang, X Dong
Live performance, bone health and metabolic responses to the interaction among stocking density and dietary concentrations of total calcium (TCa) and non-phytate phosphorus (NPP) were determined on 2,232 Ross 308 female broilers over a 3-wk experimental period. From 22 d of age, birds were randomly divided into 48 groups and provided with different corn-soybean meal-based diets varying in TCa (0.70% or 0.90%) and NPP (0.28% or 0.36%) content at 1 of 2 stocking densities [28.6 (LSD, 13 broilers/m2) and 39.6 (HSD, 18 broilers/m2) kg of predicted final BW/m2 floor space], according to a 2 × 2 × 2 factorial design with 6 replications in each treatment...
November 3, 2017: Poultry Science
https://www.readbyqxmd.com/read/29109915/mechanisms-of-oat-avena-sativa-l-acclimation-to-phosphate-deficiency
#20
Ewa Żebrowska, Marta Milewska, Iwona Ciereszko
Background: Deficiency of available forms of phosphorus is common in most soils and causes reduction of crop plants growth and yield. Recently, model plants responses to phosphate (Pi) deficiency have been intensively studied. However, acclimation mechanisms of cereals like oat (Avena sativa L.), to low Pi stress remains not fully understood. Oat plants have been usually cultured on poor soils, with a low nutrient content, but their responses to such conditions are not well known, therefore the main goal of the study was to investigate the mechanisms that enable oat plants to grow under low Pi conditions...
2017: PeerJ
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