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Oral steroids, allergic rhinitis

Nicole Powell-Dunford, Charles Reese, Alaistair Bushby, Berit H Munkeby, Sébastien Coste, Višnja Livajić Pezer, Lars Rosenkvist
INTRODUCTION: Allergic rhinitis is a prevalent condition warranting special aeromedical consideration due to its potential for acute and painful manifestations involving the middle ear or paranasal sinuses during rapid barometric pressure changes. Although second generation antihistamines and intranasal steroids are safe and effective treatments for this common condition, aeromedical management varies. METHODS: An aeromedical policy review of 14 public access civil and military data repositories was undertaken...
May 1, 2018: Aerospace Medicine and Human Performance
Adam Honeybrook, Matthew Ellison, Liana Puscas, Eileen Raynor
BACKGROUND: In February 2015, the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) published the Allergic Rhinitis Clinical Practice Guideline (AR-CPG). The objective of this study was to assess otolaryngologists' perception of the accuracy and adherence to the AR-CPG. METHODS: A survey was distributed to fellows of the American Academy of Otolaryngic Allergy and members of the American Academy of Otolaryngology-Head and Neck Surgery Foundation...
February 7, 2018: International Forum of Allergy & Rhinology
Shingo Maeda, Tatsuro Nakamura, Hiroaki Harada, Yuri Tachibana, Kosuke Aritake, Tatsuo Shimosawa, Yutaka Yatomi, Takahisa Murata
Food allergy is immediate hypersensitive reactions to ingested foods. Since early diagnosis is effective for disease control, development of an objective diagnostic index is required. Using mediator-lipidomics, we found that levels of the urinary prostaglandin D2 (PGD2 ) metabolite, tetranor-PGDM, reflected the severity of the allergic symptoms and intestinal mast cell hyperplasia in mice. Repeated oral challenges with ovalbumin promoted allergic symptoms in sensitized mice. Particularly, the allergic mice presented with increased numbers of intestinal mast cells, which strongly expressed hematopoietic PGD synthase (H-PGDS)...
December 15, 2017: Scientific Reports
Amal M Al-Moamary, Mohamed S Al-Hajjaj, Mohamed S Al Moamary
AIM: The aim of this study was to study the clinical characteristic of patient with refractory asthma (RA) from Saudi Arabia. METHODS: This paper prospectively studied in a university hospital factors leading to RA in a cohort of patients who have inadequately controlled asthma or with frequent exacerbations despite optimum controller therapy. It also studied patients with asthma that requires extended periods of oral steroids to control. RESULTS: The mean age was 45...
January 2017: Annals of Thoracic Medicine
Masakazu Ichinose, Hisatoshi Sugiura, Hiroyuki Nagase, Masao Yamaguchi, Hiromasa Inoue, Hironori Sagara, Jun Tamaoki, Yuji Tohda, Mitsuru Munakata, Kohei Yamauchi, Ken Ohta
Adult bronchial asthma is characterized by chronic airway inflammation, and presents clinically with variable airway narrowing (wheezes and dyspnea) and cough. Long-standing asthma induces airway remodeling, leading to intractable asthma. The number of patients with asthma has increased; however, the number of patients who die of asthma has decreased (1.2 per 100,000 patients in 2015). The goal of asthma treatment is to enable patients with asthma to attain normal pulmonary function and lead a normal life, without any symptoms...
April 2017: Allergology International: Official Journal of the Japanese Society of Allergology
Tsutomu Tamada, Masakazu Ichinose
As one of the candidates of the therapeutic strategy for asthma in addition to inhaled corticosteroids (ICS), leukotriene receptor antagonists (LTRAs) are known to be useful for long-term management of asthma patients complicated by allergic rhinitis (AR) or exercise-induced asthma (EIA). Currently available LTRAs are pranlukast hydrate, zafirlukast, and montelukast. These LTRAs have a bronchodilator action and inhibit airway inflammation, resulting in a significant improvement of asthma symptoms, respiratory function, inhalation frequency of as-needed inhaled β2-agonist, airway inflammation, airway hyperresponsiveness, dosage of ICSs, asthma exacerbations, and patients' QOL...
2017: Handbook of Experimental Pharmacology
Ming-Tao Yang, Chia-Chun Chen, Wang-Tso Lee, Jao-Shwann Liang, Wen-Mei Fu, Yao-Hsu Yang
BACKGROUND: Increased prevalence of attention-deficit/hyperactivity disorder (ADHD) in children with allergic rhinitis (AR) has been reported. Our previous study showed that children with untreated AR had higher ADHD scores than did the controls. OBJECTIVE: This prospective follow-up study aimed to investigate whether elevated ADHD scores in children with AR could be decreased by AR treatment. METHODS: Sixty-eight children with AR (age range, 6-14 years) and who were drug naive were enrolled and evaluated by AR symptom score, ADHD symptom scores, and computerized continuous performance test, before and after AR therapy, which included nonpharmacologic intervention, oral antihistamines, and topical steroids...
May 2016: American Journal of Rhinology & Allergy
Wai Kun, Linda L D Zhong, Liang Dai, Chung-Wah Cheng, Ai-Ping Lu, Zhao-Xiang Bian
BACKGROUND: Allergic rhinitis (AR) is one of the most common allergic diseases. The conventional treatments of allergic rhinitis are oral anti-histamines, the use of intranasal corticosteroids, and immunotherapy. Dissatisfied with the ineffectiveness and side effects of these treatments, substantial numbers of patients are turning to alternative treatments like Chinese herbal medicine, particularly Tian Jiu (TJ). TJ is a form of moxibustion in which herbal patches are applied to specific acupoints on the skin...
May 17, 2016: Trials
Rebecca Normansell, Kayleigh M Kew, Amy-Louise Bridgman
BACKGROUND: Asthma is a common long-term respiratory disease affecting approximately 300 million people worldwide. Approximately half of people with asthma have an important allergic component to their disease, which may provide an opportunity for targeted treatment. Sublingual immunotherapy (SLIT) aims to reduce asthma symptoms by delivering increasing doses of an allergen (e.g. house dust mite, pollen extract) under the tongue to induce immune tolerance. However, it is not clear whether the sublingual delivery route is safe and effective in asthma...
August 28, 2015: Cochrane Database of Systematic Reviews
Veysel Yurttas, Murat Şereflican, Mustafa Erkoçoğlu, Elçin Hakan Terzi, Aysel Kükner, Mesut Oral
Allergic rhinitis is one of the most common health problems and has a major effect on quality of life. Although new-generation antihistamines and nasal steroids are the main treatment options, complete resolution cannot be obtained in some patients. Besides common side effects such as nasal irritation and epistaxis, the use of these drugs is controversial in some patients, such as pregnant or breastfeeding women. These findings highlight the need for new treatment options. Although phototherapy has been successfully used in the treatment of atopic dermatitis, which is an IgE-mediated disease and shares several common pathogenic features with allergic rhinitis, there are limited studies about its role in the treatment of allergic rhinitis...
August 2015: Journal of Photochemistry and Photobiology. B, Biology
Carlos E Baena-Cagnani, Giorgio W Canonica, Mohamed Zaky Helal, René Maximiliano Gómez, Enrico Compalati, Mario E Zernotti, Mario Sanchez-Borges, Fabio F Morato Castro, Margarita Murrieta Aguttes, Aida López-Garcia, Faheem A Tadros
Epidemiologic studies suggest that the prevalence of allergic rhinitis (AR) is rising worldwide. Several reports, in fact, indicate increasing trends in the prevalence of AR especially in developing countries, likely related to the environment and climate changes and the adoption of an urbanized Western lifestyle. The primary objective of the present study was to collect information about management in real-life settings, including a characterization of typical patients' profile referring to physicians, the disease features, the common approaches to diagnostic assessments and therapeutic decisions...
2015: World Allergy Organization Journal
Michael D Seidman, Richard K Gurgel, Sandra Y Lin, Seth R Schwartz, Fuad M Baroody, James R Bonner, Douglas E Dawson, Mark S Dykewicz, Jesse M Hackell, Joseph K Han, Stacey L Ishman, Helene J Krouse, Sonya Malekzadeh, James Whit W Mims, Folashade S Omole, William D Reddy, Dana V Wallace, Sandra A Walsh, Barbara E Warren, Meghan N Wilson, Lorraine C Nnacheta
OBJECTIVE: Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to affect nearly 1 in every 6 Americans and generates $2 to $5 billion in direct health expenditures annually. It can impair quality of life and, through loss of work and school attendance, is responsible for as much as $2 to $4 billion in lost productivity annually...
February 2015: Otolaryngology—Head and Neck Surgery
Lino Di Rienzo Businco, Andrea Di Rienzo Businco, Luca Ventura, Salvatore Laurino, Maria Lauriello
BACKGROUND: Allergic rhinitis (AR) presents as the main and most invasive symptom in the blocking of the nose. This condition is almost always related to hypertrophy of the inferior turbinates. When the medical treatments are found to be insufficient to solve the obstructive symptom of the patient, the quality of life is considerably impaired and it is often necessary to submit the patient to a surgical approach. In the present study we aimed to establish the efficacy and safety of a new technique recently introduced for the shrinkage of hypertrophic turbinates using a specific device, based on a new radiofrequency energy that does not produce thermal mucosal damage, viz...
March 2014: American Journal of Rhinology & Allergy
Kristen DeYoung, Jennifer L Wentzel, Rodney J Schlosser, Shaun A Nguyen, Zachary M Soler
BACKGROUND: Immunotherapy (IT) has been well established as an effective treatment for allergic rhinitis (AR), but little is known about the benefits of IT on clinical outcomes of comorbid chronic rhinosinusitis (CRS). The goal of this publication is to systematically review the literature regarding outcomes of IT in patients with atopic CRS. METHODS: A systematic review of the literature was conducted including studies that assessed the efficacy of IT on clinical outcome measures in CRS including without polyp, with polyp, and allergic fungal rhinosinusitis subgroups...
March 2014: American Journal of Rhinology & Allergy
Virat Kirtsreesakul, Jitanong Leelapong, Suwalee Ruttanaphol
BACKGROUND: Although nasal peak flow measurements have been proposed as a simple alternative method to assess nasal patency, which of nasal peak expiratory flow or nasal peak inspiratory flow (NPEF/NPIF) or the peak expiratory flow index or peak inspiratory flow index (PEFI/PIFI; the ratios between nasal and oral PEF or nasal and oral PIF, respectively) is the more accurate method is unclear. The aim of this study was to evaluate the correlation between NPEF, NPIF, PEFI, and PIFI, and blocked nose score (BNS) and mucociliary clearance time (MCCT) in diagnostic and follow-up assessments...
March 2014: American Journal of Rhinology & Allergy
E V Avallone, C Cassieri, M Zippi, R Pica, A Marcheggiano, P Vernia, E S Corazziari, P Paoluzi
Eosinophilic esophagitis (EoE) is the most common form of gastrointestinal disorders associated with eosinophilia. Typically, an inappropriate accumulation of eosinophils is found in the esophageal mucosa. EoE can be well managed and treated with several options that include an elimination diet, drug therapy (oral and topical steroids) and esophageal dilatations. We herein, report a case of a 49-year-old male affected by EoE associated to chest pain, treated with proton pump inhibitor without clinical response...
2014: La Clinica Terapeutica
Fulvio Braido, Francesca Sclifò, Matteo Ferrando, Giorgio Walter Canonica
Because of its burden on patient's lives and its impact on asthma, allergic rhinitis must be treated properly with more effective and safer treatments. According to guidelines by Allergic Rhinitis and Its Impact on Asthma (ARIA), the classification, pathogenesis, and treatment of allergic rhinitis are well defined. Currently, second-generation antihistamines and inhaled steroids are considered the cornerstone of first-line therapy. However, new formulations of available drugs (e.g., loratadine and rupatadine oral solution, ebastine fast-dissolving tablets, and the combination of intranasal fluticasone propionate and azelastine hydrochloride), recently discovered molecules (e...
April 2014: Current Allergy and Asthma Reports
Emel Çadallı Tatar, Unzile Akpınar Sürenoğlu, Ali Ozdek, Güleser Saylam, Hakan Korkmaz
Allergic rhinitis may significantly affect the patients' quality of life. The aim of this study was to compare the effects of nasal steroids alone, to nasal steroids plus Levocetirizine or Montelukast, on quality of life in persistent allergic rhinitis. This is a prospective, randomized study and included 56 patients with moderate to severe persistent allergic rhinitis. All patients had house dust mite allergy on skin prick test and we divided the patients into three groups. 1 month long medical treatment was; topical Mometasone furoate 200 mcg/day in the first group (n:14), Mometasone furoate 200 mcg/day plus oral Levocetirizine 5 mg/day in the second group (n:21), and Mometasone furoate 200 mcg/day plus oral Montelukast 10 mg/day in the third group (n:21)...
August 2013: Indian Journal of Otolaryngology and Head and Neck Surgery
Said Chaaban, Victor Salloum
SESSION TYPE: Miscellaneous Student/Resident Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Chronic eosinophilic pneumonia is a syndrome usually associated with atopic manifestations, nonspecific pulmonary manifestations, chest imaging findings suggestive of peripheral alveolar opacities, as well as alveolar and blood eosinophilia. (1) Onset is usually insidious with symptoms lasting up to two to four weeks. Symptoms include dry cough, dyspnea, as well as other systemic manifestations such as fever and weight loss...
October 1, 2012: Chest
Samantha Gendelman, Andrew Zeft, Steven J Spalding
OBJECTIVE: To date only 38 cases of childhood-onset eosinophilic granulomatosis with polyangiitis (cEGPA; formerly Churg-Strauss syndrome) have been reported. Additional patients with cEGPA could enhance the understanding of this rare and life-threatening condition. Our objectives were (1) to determine the frequency of specific organ system involvement; (2) to examine initial therapeutic regimen; and (3) to document disease and therapy-related morbidity in a contemporary cohort of patients with cEGPA...
June 2013: Journal of Rheumatology
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