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Diego Gomez-Arbelaez, Diego Bellido, Ana I Castro, Lucia Ordoñez-Mayan, Jose Carreira, Cristobal Galban, Miguel A Martinez-Olmos, Ana B Crujeiras, Ignacio Sajoux, Felipe F Casanueva
CONTEXT: A common concern when using low-calorie diets as a treatment for obesity is the reduction in fat-free mass, mostly muscular mass that occurs together with the fat mass loss, and the best methodologies to evaluate body composition changes. OBJECTIVE: To evaluate the very low-calorie-ketogenic (VLCK) diet-induced changes in body composition of obese patients and to compare three different methodologies employed to evaluate that changes. DESIGN: Twenty obese patients followed a VLCK diet for 4 months...
October 18, 2016: Journal of Clinical Endocrinology and Metabolism
Ramon Vilallonga, José Manuel Moreno Villares, Diego Yeste Fernández, Raquel Sánchez Santos, Felipe Casanueva Freijo, Francisco Santolaya Ochando, Nuria Leal Hernando, Albert Lecube Torelló, Luis Antonio Castaño González, Albert Feliu, Gontrand Lopez-Nava, Dolores Frutos, Antonio J Torres Garcia, Juan Carlos Ruiz de Adana
PURPOSE: In recent years, the incidence of childhood obesity in Europe, and Spain in particular, has increased dramatically. Bariatric surgery could play a major role in treating of adolescents with severe obesity. However, no specific guidelines for bariatric surgery currently exist in Spain. METHODS: The Board of the Spanish Society for Obesity Surgery and Metabolic Diseases (SECO) proposed a study of childhood obesity by using the Delphi method. This prospective study involved 60 experts from nine national societies...
October 17, 2016: Obesity Surgery
Cheryl Li, Olivia Casanueva
Abundant evidence shows that the genome is not as static as once thought and that gene expression can be reversibly modulated by the environment. In some cases, these changes can be transmitted to the next generation even if the environment has reverted. Such transgenerational epigenetic inheritance requires that information be stored in the germline in response to exogenous stressors. One of the most elusive questions in the field of epigenetic inheritance is the identity of such inherited factor(s). Answering this question would allow us to understand how the environment can shape human populations for multiple generations and may help to explain the rapid rise in obesity and neurodegenerative diseases in modern society...
October 15, 2016: Essays in Biochemistry
Diego Pérez-Sotelo, Arturo Roca-Rivada, María Larrosa-García, Cecilia Castelao, Iván Baamonde, Javier Baltar, Ana Belen Crujeiras, Luisa María Seoane, Felipe F Casanueva, María Pardo
The secretion of the hepatokine alpha-2-Heremans-Schmid glycoprotein/Fetuin A, implicated in pathological processes including systemic insulin resistance, by adipose tissue has been recently described. Thus, we have recently identified its presence in white adipose tissue secretomes by mass spectrometry. However, the secretion pattern and function of adipose-derived alpha-2-Heremans-Schmid glycoprotein are poorly understood. The aim of this study is to evaluate the expression and secretion of total and active phosphorylated alpha-2-Heremans-Schmid glycoprotein by adipose tissue from visceral and subcutaneous localizations in animals at different physiological and nutritional status including anorexia and obesity...
October 14, 2016: Endocrine
Thang S Han, Elon Correa, Michael E J Lean, David M Lee, Terrence W O'Neill, György Bartfai, Gianni Forti, Aleksander Giwercman, Krzysztof Kula, Neil Pendleton, Margus Punab, Martin K Rutter, Dirk Vanderschueren, Ilpo T Huhtaniemi, Frederick C W Wu, Felipe F Casanueva
Diversity in lifestyles and socioeconomic status among European populations, and recent socio-political and economic changes in transitional countries, may affect changes in adiposity. We aimed to determine whether change in the prevalence of obesity varies between the socio-politically transitional North-East European (Łódź, Poland; Szeged, Hungary; Tartu, Estonia), and the non-transitional Mediterranean (Santiago de Compostela, Spain; Florence, Italy) and North-West European (Leuven, Belgium; Malmö, Sweden; Manchester, UK) cities...
October 13, 2016: Endocrine
Nuria Mallorquí-Bagué, Ana B Fagundo, Susana Jimenez-Murcia, Rafael de la Torre, Rosa M Baños, Cristina Botella, Felipe F Casanueva, Ana B Crujeiras, Jose C Fernández-García, Jose M Fernández-Real, Gema Frühbeck, Roser Granero, Amaia Rodríguez, Iris Tolosa-Sola, Francisco J Ortega, Francisco J Tinahones, Eva Alvarez-Moya, Cristian Ochoa, Jose M Menchón, Fernando Fernández-Aranda
INTRODUCTION: Addictions are associated with decision making impairments. The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling Task (IGT) and compares them with healthy controls (HC). METHODS: For the aims of this study, 591 participants (194 HC, 178 GD, 113 OB, 106 SUD) were assessed according to DSM criteria, completed a sociodemographic interview and conducted the IGT...
2016: PloS One
Santiago Rodriguez-Segade, Javier Rodriguez Garcia, José M García-López, Francisco Gude, Felipe F Casanueva, Santiago Rs-Alonso, Félix Camiña
BACKGROUND: Several hematological alterations are associated with altered hemoglobin A1c (Hb A1c). However, there have been no reports of their influence on the rates of exceeding standard Hb A1c thresholds by patients for whom Hb A1c determination is requested in clinical practice. METHODS: The initial data set included the first profiles (complete blood counts, Hb A1c, fasting glucose, and renal and hepatic parameters) of all adult patients for whom such a profile was requested between 2008 and 2013 inclusive...
September 27, 2016: Clinical Chemistry
A Goday, D Bellido, I Sajoux, A B Crujeiras, B Burguera, P P García-Luna, A Oleaga, B Moreno, F F Casanueva
UNLABELLED: Brackground:The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment of obese type 2 diabetes mellitus (T2DM) patients. OBJECTIVE: Evaluating the short-term safety and tolerability of a VLCK diet (<50 g of carbohydrate daily) in an interventional weight loss program including lifestyle and behavioral modification support (Diaprokal Method) in subjects with T2DM. METHODS: Eighty-nine men and women, aged between 30 and 65 years, with T2DM and body mass index between 30 and 35 kg m(-)(2) participated in this prospective, open-label, multi-centric randomized clinical trial with a duration of 4 months...
2016: Nutrition & Diabetes
Robert J A H Eendebak, Ilpo Huhtaniemi, Stephen R Pye, Tomas Brian Ahern, Terence W O'Neill, Gyorgy Bartfai, Felipe F Casanueva, Mario Maggi, Gianni Forti, Robert D Alston, Aleksander Giwercman, Thang S Han, Krzysztof Kula, Mike Lean, Margus Punab, Neil Pendleton, Brian Keevil, Dirk Vanderschueren, Martin Kenneth Rutter, Gindo Tampubolon, Royston Goodacre, Fredrick C W Wu
CONTEXT: The Androgen Receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. OBJECTIVE: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints which are influenced by testosterone (T) levels in middle-aged and elderly European men...
September 15, 2016: European Journal of Endocrinology
Basilio Moreno, Ana B Crujeiras, Diego Bellido, Ignacio Sajoux, Felipe F Casanueva
The long-term effect of therapeutic diets in obesity treatment is a challenge at present. The current study aimed to evaluate the long-term effect of a very low-calorie-ketogenic (VLCK) diet on excess adiposity. Especial focus was set on visceral fat mass, and the impact on the individual burden of disease. A group of obese patients (n = 45) were randomly allocated in two groups: either the very low-calorie-ketogenic diet group (n = 22), or a standard low-calorie diet group; (n = 23). Both groups received external support...
September 13, 2016: Endocrine
Ines Hilker, Isabel Sánchez, Trevor Steward, Susana Jiménez-Murcia, Roser Granero, Ashley N Gearhardt, Rita Cristina Rodríguez-Muñoz, Carlos Dieguez, Ana B Crujeiras, Iris Tolosa-Sola, Felipe F Casanueva, José M Menchón, Fernando Fernández-Aranda
: Food addiction (FA) has been examined in different populations. Although high FA levels are associated with greater eating disorder severity, few studies have addressed how FA relates to treatment outcome. GOALS: The study aims (1) to determine whether a brief intervention for bulimia nervosa (BN) reduces FA diagnosis or severity compared with baseline and (2) to determine if FA is predictive of treatment outcome. METHOD: Sixty-six female BN patients participated in the study...
September 4, 2016: European Eating Disorders Review: the Journal of the Eating Disorders Association
Fernando Casanueva, Deniz Gerecci
Importance: The dome binding suture (DBS) used for nasal tip refinement creates the unwanted effects of nasal tip pinching owing to shadowing and loss of alar support. The hemitransdomal suture (HTS), however, refines the nasal tip while maintaining a natural contour between the nasal tip and the alar lobule. To our knowledge, no objective comparison between the DBS and HTS techniques has been described in the literature to date. Objective: To determine whether the DBS or HTS technique results in an objectively satisfactory outcome in nasal tip contouring when assessed from the perspective of the basal view...
September 1, 2016: JAMA Facial Plastic Surgery
Katherine A Abrahams, Chun-Wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S Gurcha, Jonathan A G Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J Loman, Patrick J Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S Besra, Robert H Bates
Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific single-nucleotide polymorphisms in the essential Mycobacterium tuberculosis β-ketoacyl synthase (kas) A gene. Here, this genomic-based target assignment is confirmed by biochemical assays, chemical proteomics and structural resolution of a KasA-GSK3011724A complex by X-ray crystallography...
2016: Nature Communications
Trevor Steward, Gemma Mestre-Bach, Zaida Agüera, Roser Granero, Virginia Martín-Romera, Isabel Sánchez, Nadine Riesco, Iris Tolosa-Sola, Jose A Fernández-Formoso, Jose C Fernández-García, Francisco J Tinahones, Felipe F Casanueva, Rosa M Baños, Cristina Botella, Ana B Crujeiras, Rafael de la Torre, Jose M Fernández-Real, Gema Frühbeck, Francisco J Ortega, Amaia Rodríguez, Susana Jiménez-Murcia, Jose M Menchón, Fernando Fernández-Aranda
BACKGROUND: Deficits in neuropsychological functioning have consistently been identified in patients with anorexia nervosa (AN). However, little is known on how decision making in AN patients evolves in response to treatment or whether impairments are reversible. METHOD: AN patients (n = 42) completed the Iowa Gambling Task (IGT) upon admission to a 3-month day-hospital treatment programme and at a 1-year follow-up. Patient IGT performance was compared to age-matched controls (n = 46)...
August 31, 2016: European Eating Disorders Review: the Journal of the Eating Disorders Association
Albert Lecube, Susana Monereo, Miguel Ángel Rubio, Purificación Martínez-de-Icaya, Amelia Martí, Javier Salvador, Lluís Masmiquel, Alberto Goday, Diego Bellido, Empar Lurbe, José Manuel García-Almeida, Francisco José Tinahones, Pedro Pablo García-Luna, Enrique Palacio, Manuel Gargallo, Irene Bretón, Salvador Morales-Conde, Assumpta Caixàs, Edelmiro Menéndez, Manel Puig-Domingo, Felipe F Casanueva
No abstract text is available yet for this article.
August 16, 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
A B Crujeiras, A Diaz-Lagares, J M Moreno-Navarrete, J Sandoval, D Hervas, A Gomez, W Ricart, F F Casanueva, M Esteller, J M Fernandez-Real
Elucidating the potential mechanisms involved in the detrimental effect of excess body weight on insulin action is an important priority in counteracting obesity-associated diseases. The present study aimed to disentangle the epigenetic basis of insulin resistance by performing a genome-wide epigenetic analysis in visceral adipose tissue (VAT) from morbidly obese patients depending on the insulin sensitivity evaluated by the clamp technique. The global human methylome screening performed in VAT from 7 insulin-resistant (IR) and 5 insulin-sensitive (IS) morbidly obese patients (discovery cohort) analyzed using the Infinium HumanMethylation450 BeadChip array identified 982 CpG sites able to perfectly separate the IR and IS samples...
July 15, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
A B Fagundo, S Jiménez-Murcia, C Giner-Bartolomé, Z Agüera, S Sauchelli, M Pardo, A B Crujeiras, R Granero, R Baños, C Botella, R de la Torre, J M Fernández-Real, J C Fernández-García, G Frühbeck, A Rodríguez, N Mallorquí-Bagué, S Tárrega, F J Tinahones, R Rodriguez, F Ortega, J M Menchón, F F Casanueva, F Fernández-Aranda
Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task...
2016: Scientific Reports
Cristina Guillín-Amarelle, Sofía Sánchez-Iglesias, Ana Castro-Pais, Leticia Rodriguez-Cañete, Lucía Ordóñez-Mayán, Marcos Pazos, Blanca González-Méndez, Silvia Rodríguez-García, Felipe F Casanueva, Ana Fernández-Marmiesse, David Araújo-Vilar
Familial partial lipodystrophy are Mendelian disorders involving abnormal body fat distribution and insulin resistance. The current classification includes the Köbberling syndrome (type 1 familial partial lipodystrophy), characterized by fat loss in the lower limbs and abnormal fat accumulation in other areas. Type 1 familial partial lipodystrophy appears to be heritable, but little is known about it, including putative contributing mutations. We aimed to characterize this syndrome better by evaluating a group of women with phenotypic features of type 1 familial partial lipodystrophy...
July 30, 2016: Endocrine
Maria Cristina Cuerda, Antonio Apezetxea, Lourdes Carrillo, Felipe Casanueva, Federico Cuesta, Jose Antonio Irles, Maria Nuria Virgili, Miquel Layola, Luis Lizán
INTRODUCTION: NutriQoL(®) (Nestlé Health Science, Vevay, Switzerland) is a questionnaire developed to assess the health-related quality-of-life (HRQoL) of patients with home enteral nutrition (HEN) irrespective of their underlying condition and route of administration. The aim of this work is assessing the questionnaire's reliability and responsiveness to change. METHODS: Two cohorts of patients with HEN and their primary caregivers were enrolled to assess reliability and responsiveness, respectively...
October 2016: Advances in Therapy
Dane M Barrett, Fernando J Casanueva, Ted A Cook
The nasal valve is an important consideration in patients presenting with nasal obstruction. Controversy exists regarding the anatomy, terminology, evaluation, and management of the nasal valve. Innumerable techniques with variable effects have been described in the literature. The evidence qualifying these techniques has been plentiful, though often lacking in quality. This article reviews the controversial aspects of nasal valve management applying the best available evidence to help clarify potential areas of confusion...
August 2016: Facial Plastic Surgery Clinics of North America
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