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JOURNAL ARTICLE
Mohammad R Ostovaneh, Timothy M Hughes, Colin O Wu, Robyn L McClelland, Ramon Casanova, David A Bluemke, Russell P Tracy, Steven Shea, Susan R Heckbert, João A C Lima, Bharath Ambale-Venkatesh
BACKGROUND: Our understanding of the specific aspects of vascular contributions to dementia remains unclear. OBJECTIVES: We aim to identify the correlates of incident dementia in a multi-ethnic cardiovascular cohort. METHODS: A total of 6806 participants with follow-up data for incident dementia were included. Probable dementia diagnoses were identified using hospitalization discharge diagnoses according to the International Classification of Diseases Codes (ICD)...
2024: PloS One
#2
REVIEW
Jean-Laurent Casanova, John D MacMicking, Carl F Nathan
Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon- γ (IFN- γ ), a protein secreted by lymphocytes. Forty years ago, IFN- γ was identified as a macrophage-activating factor, and, in recent years, there has been a resurgent interest in IFN- γ biology and its role in human defense...
April 19, 2024: Science
#3
JOURNAL ARTICLE
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner, Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake, Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs, Zoe Quandt, Andrew T Hattersley, Peng Zhang, Stephanie Boisson-Dupuis, Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram
We previously reported two siblings with inherited PD-1 deficiency who died from autoimmune pneumonitis at 3 and 11 years of age after developing other autoimmune manifestations, including type 1 diabetes (T1D). We report here two siblings, aged 10 and 11 years, with neonatal-onset T1D (diagnosed at the ages of 1 day and 7 wk), who are homozygous for a splice-site variant of CD274 (encoding PD-L1). This variant results in the exclusive expression of an alternative, loss-of-function PD-L1 protein isoform in overexpression experiments and in the patients' primary leukocytes...
June 3, 2024: Journal of Experimental Medicine
#4
JOURNAL ARTICLE
Clarissa Murru, Lucas Duvert, Frederique Magdinier, Adrien Casanova, Anne-Patricia Alloncle, Stefano Testa, Ahmed Al-Kattan
Due to their biocompatibility and biodegradability and their unique structural and physicochemical properties, laser-synthesized silicon nanoparticles (Si-NPs) are one of the nanomaterials which have been most studied as potential theragnostic tools for non-invasive therapeutic modalities. However, their ability to modulate cell behavior and to promote proliferation and differentiation is still very little investigated or unknown. In this work, ultrapure ligand free Si-NPs of 50 ± 11.5 nm were prepared by femtosecond (fs) laser ablation in liquid...
April 16, 2024: Nanoscale advances
#5
JOURNAL ARTICLE
Mar Lozano-Casanova, Isabel Sospedra, Antonio Oliver-Roig, Miguel Richart-Martinez, Ana Gutierrez-Hervas
Parental feeding practices, such as the use of food to soothe, can be shaped by various factors, including the family environment and parents' psychological characteristics and capacities. To our knowledge, the combined effect of these factors has not been studied. Furthermore, parental feeding practices have mainly been studied in women, resulting in a gender gap in the research. This study aims to investigate the combined effect of family environment and parental characteristics on the likelihood of using food to soothe children, taking the gender of both parents into account...
April 2024: Food Science & Nutrition
#6
JOURNAL ARTICLE
Jorge A Tricio, Catalina Braithwaite, Constanza M Herrera, Daniela P Vicuña, Franco R Cacciuttolo, Gilbert A Jorquera, Mario F Gutiérrez, Christian G Córdova, Pablo A Villalón, Gustavo A Moncada, Renzo A Casanova, María I González, Macarena A Ilić Dent Stud, César A Orsini
INTRODUCTION: Three-dimensional (3D)-printing technology can provide customizable simulations, but its effects on patient care quality have not been well studied. This study aimed to assess the impact of practicing with patient-specific 3D-printed teeth models on the quality of patients' dental preparations performed by students transitioning to clinical training. Accordingly, the quality of posterior crown preparations was evaluated by objectively analyzing digital scans and grades in two groups: the study group, which practiced beforehand with patient-specific 3D-printed teeth models, and the control group, which did not practice with these models...
April 16, 2024: Journal of Dental Education
#7
JOURNAL ARTICLE
Sraddha Agrawal, Bipeng Wang, Yifan Wu, David Casanova, Oleg V Prezhdo
Two-dimensional graphitic carbon nitride (GCN) is a popular metal-free polymer for sustainable energy applications due to its unique structure and semiconductor properties. Dopants and defects are used to tune GCN, and dual defect modified GCN exhibits superior properties and enhanced photocatalytic efficiency in comparison to pristine or single defect GCN. We employ a multistep approach combining time-dependent density functional theory and nonadiabatic molecular dynamics (NAMD) with machine learning (ML) to investigate coupled structural and electronic dynamics in GCN over a nanosecond timescale, comparable to and exceeding the lifetimes of photo-generated charge carriers and photocatalytic events...
April 16, 2024: Nanoscale
#8
JOURNAL ARTICLE
X Surís, M J Pueyo-Sánchez, A Ricart, A Naranjo, T Casanova, C Gómez-Vaquero, E Duaso, J M Cancio-Trujillo, J Sánchez-Martín, A Pérez-Mitru
OBJECTIVE: To assess the cost-effectiveness of Fracture Liaison Service (FLS) compared to the standard of care for secondary prevention of fragility fractures form the perspective of the Catalan Health Service. METHODS: Cost-utility assessment through a Markov model that simulated disease progression of a patients' cohort candidates to initiate antiosteoporotic treatment after a fragility fracture. A time horizon of 10 years and a 6-month duration per cycle was established...
April 12, 2024: Journal of Healthcare Quality Research
#9
JOURNAL ARTICLE
Silvia de la Mata Moratilla, Sandra Casado Angulo, Natalia Gómez-Casanova, José Luis Copa-Patiño, Irene Heredero-Bermejo, Francisco Javier de la Mata, Sandra García-Gallego
Antibiotic resistance is currently a global health emergency. Metallodrugs, especially metal coordination complexes, comprise a broad variety of candidates to combat antibacterial infections. In this work, we designed a new family of Schiff base zinc(II) complexes with iminopyridine as an organic ligand and different inorganic ligands: chloride, nitrate, and acetate. The antibacterial effect of the Zn(II) complexes was studied against planktonic bacterial cells of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) strains...
April 4, 2024: International Journal of Molecular Sciences
#10
JOURNAL ARTICLE
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphael Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, James Mullikin, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian T Mayer, Sergio D Rosenzweig, Luigi D Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean-Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death. Here, we report two individuals with SHARPIN deficiency who manifest autoinflammatory symptoms but unexpectedly no dermatological problems. Fibroblasts and B cells from these individuals showed attenuated canonical NF-κB responses and a propensity for cell death mediated by TNF superfamily members...
April 12, 2024: Nature Immunology
#11
Alfredo G Casanova, Ana I Morales, Laura Vicente-Vicente, Francisco J López-Hernández
Accumulating evidence suggests that hyperuricemia is a pathological factor in the development and progression of chronic kidney disease. However, the potential benefit afforded by the control of uric acid (UA) is controversial. Individual studies show discrepant results, and most existing meta-analysis, especially those including the larger number of studies, lack a placebo or control group as they aim to compare efficacy between drugs. On these grounds, we performed a me-ta-analysis restricted to studies including the action of any anti-gout therapies referenced to a control or placebo arm...
2024: Frontiers in Pharmacology
#12
João Martins Gama, Rui Caetano Oliveira, Rúben Fonseca, Maria Augusta Cipriano, José Casanova
Extraskeletal myxoid chondrosarcoma is a rare soft tissue tumour with a high local and distant metastasis rate and limited response to chemotherapy. Meckel's diverticulum is the most frequent congenital anomaly, and it is associated with a considerable risk of malignant transformation. In this case report, we describe a 50-year-old female patient with a history of extraskeletal myxoid chondrosarcoma of the lower limb and metastasis to the forearm who went to the emergency department with abdominal pain. The investigations revealed a caecal volvulus...
2024: Revista Española de Patología
#13
JOURNAL ARTICLE
Manuel Suárez-Rodríguez, Beatriz Martín-García, Witold Skowroński, Kamil Staszek, Francesco Calavalle, Albert Fert, Marco Gobbi, Fèlix Casanova, Luis E Hueso
Wireless radiofrequency rectifiers have the potential to power the billions of "Internet of Things" devices currently in use by effectively harnessing the ambient electromagnetic radiation. However, the current technology relies on the implementation of rectifiers based on Schottky diodes, which exhibit limited capabilities for high-frequency and low-power applications. Consequently, they require an antenna to capture the incoming signal and amplify the input power, thereby limiting the possibility of miniaturizing devices to the millimeter scale...
April 10, 2024: Advanced Materials
#14
JOURNAL ARTICLE
Andrew J Petkus, Xinhui Wang, Diana Younan, Lauren E Salminen, Susan M Resnick, Stephen R Rapp, Mark A Espeland, Margaret Gatz, Keith F Widaman, Ramon Casanova, Helena Chui, Ryan T Barnard, Sarah A Gaussoin, Joseph S Goveas, Kathleen M Hayden, Victor W Henderson, Bonnie C Sachs, Santiago Saldana, Aladdin H Shadyab, Sally A Shumaker, Jiu-Chiuan Chen
INTRODUCTION: The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes. METHODS: Utilizing joint latent class mixture models, we identified longitudinal trajectories of annually assessed depressive symptoms and dementia risk over 21 years in 957 older women (baseline age 72.7 years old) from the Women's Health Initiative Memory Study. In a subsample of 569 women who underwent structural magnetic resonance imaging, we examined whether estimates of cerebrovascular disease and Alzheimer's disease (AD)-related neurodegeneration were associated with identified trajectories...
April 9, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#15
JOURNAL ARTICLE
Junhyeon Jo, Samuel Mañas-Valero, Eugenio Coronado, Fèlix Casanova, Marco Gobbi, Luis E Hueso
van der Waals magnets are emerging as a promising material platform for electric field control of magnetism, offering a pathway toward the elimination of external magnetic fields from spintronic devices. A further step is the integration of such magnets with electrical gating components that would enable nonvolatile control of magnetic states. However, this approach remains unexplored for antiferromagnets, despite their growing significance in spintronics. Here, we demonstrate nonvolatile electric field control of magnetoelectric characteristics in van der Waals antiferromagnet CrSBr...
April 8, 2024: Nano Letters
#16
JOURNAL ARTICLE
Susana Ochoa, Victoria Espinosa, Raquel López-Carrilero, Irene Martinez, Alejandro De Haro Barrera, Irene Birulés, Ana Barajas, Trinidad Pélaez, Luciana Díaz-Cutraro, Marta Coromina, Alexandre González-Rodríguez, Marina Verdaguer-Rodríguez, Alfonso Gutiérrez-Zotes, Carolina Palma-Sevillano, Cristian Montes, Judith Gallego, Beatriz Paya, Francesc Casanovas, María Roldán, Emma Noval, Paloma Varela Casals, Miriam Salas-Sender, Ana Aznar, Rosa Ayesa-Arriola, Esther Pousa, Manuel Canal-Rivero, Nathalia Garrido-Torres, Clara Montserrat, Laura Muñoz-Lorenzo, Josep María Crosas
BACKGROUND: More than half of women with psychosis take care of their children despite the difficulties caused by the disease. Additionally, these kids have a higher risk of developing a mental health disorder. However, no interventions have been developed to meet these needs. Metacognitive Training (MCT) is a psychological intervention that has demonstrated its efficacy in improving cognitive insight, symptom management and social cognition in people with first-episode psychosis (FEP)...
2024: Frontiers in Psychology
#17
JOURNAL ARTICLE
J Curtis Nickel, Stephen Foley, Bob Yang, Miguel Casanovas, Raquel Caballero, Carmen María Diez-Rivero, María-Fernanda Lorenzo-Gómez
BACKGROUND: Recurrent urinary tract infection (rUTI) remains a major health burden for women. A randomized, double-blind, placebo-controlled trial (RCT; NCT02543827) reported that female patients with rUTI receiving a sublingual vaccine, MV140, had a reduction in rUTI and increase in UTI-free rate compared with placebo. OBJECTIVE: To determine the impact of MV140 on the personal burden of disease in women with rUTI using secondary endpoint data from the pivotal RCT evaluating MV140...
May 2024: European urology open science
#18
JOURNAL ARTICLE
Baraa Nakdali Kassab, Pedro De Pablos-Rodríguez, Álvaro Gómez Ferrer, Antonio Coy García, Ana Calatrava Fons, Fuensanta Aragón, Juan Casanova Ramón-Borja, Miguel Ramírez-Backhaus
BACKGROUND: Evidence regarding the relationship between the laterality of lymph node invasion (LNI) and the prostatic lobe affected is limited. Our aim was to review our records of patients with exclusively unilateral localised prostate cancer (PCa) with metastatic LN involvement. METHODS: Between 2006 and 2023, after radical prostatectomy and extended pelvic lymphadenectomy at our centre, thirty patients with intermediate-high risk unilateral PCa and pN1 disease were identified...
March 2024: Archivos Españoles de Urología
#19
JOURNAL ARTICLE
Gwenn Pinel, Ugo Berthelot, Lucas Sales Queiroz, Livia De Almeida Santiago, Naaman Francisco Nogueira Silva, Heidi Olander Petersen, Jens J Sloth, Ipek Altay, Rodolphe Marie, Aberham Hailu Feyissa, Federico Casanova, Alain Doyen
Edible insects represent a great alternative protein source but food neophobia remains the main barrier to consumption. However, the incorporation of insects as protein-rich ingredients, such as protein concentrates, could increase acceptance. In this study, two methods, isoelectric precipitation and ultrafiltration-diafiltration, were applied to produce mealworm protein concentrates, which were compared in terms of composition, protein structure and techno-functional properties. The results showed that the protein content of the isoelectric precipitation concentrate was higher than ultrafiltration-diafiltration (80 versus 72%) but ash (1...
April 2, 2024: Food Chemistry
#20
JOURNAL ARTICLE
Blanca García-Solís, María Tapia-Torres, Ana García-Soidán, Elisa Hernández-Brito, María Teresa Martínez-Saavedra, José M Lorenzo Salazar, Sonia García-Hernández, Ana Van Den Rym, Karan Mayani Mayani, José Vicente Govantes-Rodríguez, Adrian Gervais, Paul Bastard, Anne Puel, Jean-Laurent Casanova, Carlos Flores, Rebeca Pérez de Diego, Carlos Rodríguez-Gallego
BACKGROUND: Monoallelic loss-of-function IKZF1 (IKAROS) variants cause B-cell deficiency or combined immunodeficiency, whereas monoallelic gain-of-function IKZF1 variants have recently been reported to cause hypergammaglobulinemia, abnormal plasma cell differentiation, autoimmune and allergic manifestations, and infections. METHODS: We studied seven relatives with autoimmune/inflammatory diseases and lymphoproliferative diseases. We analysed biopsy results and performed whole-exome sequencing and immunological studies...
April 3, 2024: Journal of Allergy and Clinical Immunology
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