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Diego López-Carballeira, David Casanova, Fernando Ruiperez
The geometrical and electronic structures of 44 squarate and croconate derivatives are computationally studied in this work using theoretical methods of quantum chemistry, in the pursuit of new singlet fission sensitizers. Non-negligible singlet open-shell diradical character is observed for most of the studied molecules, which can be controlled through chemical substitution as well as by the size of the central ring. Such diradical character is related to small singlet-triplet energy gaps, facilitating the accomplishment of the singlet fission energetic requirements...
May 23, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
David M Alba, Isaac Casanovas-Vilar, Marc Furió, Israel García-Paredes, Chiara Angelone, Sílvia Jovells-Vaqué, Àngel H Luján, Sergio Almécija, Salvador Moyà-Solà
In the Iberian Peninsula, Miocene apes (Hominoidea) are generally rare and mostly restricted to the Vallès-Penedès Basin. Here we report a new hominoid maxillary fragment with M2 from this basin. It was surface-collected in March 2017 from the site of Can Pallars i Llobateres (CPL, Sant Quirze del Vallès), where fossil apes had not been previously recorded. The locality of provenance (CPL-M), which has delivered no further fossil remains, is located very close (ca. 50 m) to previously known CPL outcrops, and not very far (ca...
May 18, 2018: Journal of Human Evolution
Carmen Alcalá, F Gascón, F Pérez-Miralles, S Gil-Perotín, A Navarré, I Boscá, F Coret, B Casanova
INTRODUCTION: Rituximab is considered as a potential therapeutic option in relapsing-remitting (RRMS) and progressive forms (PMS) of multiple sclerosis (MS). OBJECTIVE: To investigate the effectiveness and safety of rituximab in MS. PATIENTS AND METHODS: Observational study of effectiveness (clinical and radiological) and safety of rituximab in RRMS and PMS. RESULTS: A total of 90 rituximab-treated patients were collected: 31 RRMS and 59 PMS All patients had an active disease despite standard treatment...
May 21, 2018: Journal of Neurology
Jian Wang, Gakhyun Kim, María Eugenia Sandoval-Salinas, Hoa Phan, Tullimilli Y Gopalakrishna, Xuefeng Lu, David Casanova, Dongho Kim, Jishan Wu
We report the first class of stable, two-dimensional (2D) anti-ferromagnetically coupled dendritic polyradicaloids. A kinetically blocked fluorenyl radical was used to build up the first and second generation dendrons FR-G1 and FR-G2 containing three and seven fluorenyl units, respectively. The neighboring fluorenyl radicals in FR-G1 and FR-G2 show moderate anti-ferromagnetic exchange interaction, resulting in a doublet and quartet ground state, respectively, with a small doublet-quartet energy gap. From FR-G1 to FR-G2 , the energy gap decreased and the two-photon absorption was enhanced owing to more extended 2D π-conjugation...
April 7, 2018: Chemical Science
F Delaunay, D Coquerel-Beghin, G Magalon, S R Cohen, D Casanova, J Niddam, P-Y Milliez, C Peillon, V Delpierre, I Auquit-Auckbur
BACKGROUND: Smoking induces complications in plastic surgery, in particular wound healing delays. Despite a 4-weeks' abstinence asking before and after surgery, some patients denied or hid their consumption. The aim of this study was to evaluate the effectiveness of a cotininury detection test in terms of improvement in outcomes after an abdominoplasty. MATERIAL AND METHODS: This retrospective cohort study included patients who underwent an abdominoplasty with umbilical transposition and lipoaspiration...
May 16, 2018: Annales de Chirurgie Plastique et Esthétique
Nadja F Bednarczuk, Marta Casanovas Ortega, Anne-Sophie Fluri, Qadeer Arshad
Vestibular processing and anxiety networks are functionally intertwined, as demonstrated by reports of reciprocal influences upon each other. Yet whether there is an underlying link between these two systems remains unknown Previous findings have highlighted the involvement of hemispheric lateralisation in processing of both anxiety and vestibular signals. Accordingly, we explored the interaction between vestibular cortical processing and anxiety by assessing the relationship between anxiety levels and the degree of hemispheric lateralisation of vestibulo-cortical processing in 64 right-handed, healthy individuals...
May 16, 2018: European Journal of Neuroscience
Clàudia Cerveró, Alba Blasco, Olga Tarabal, Anna Casanovas, Lídia Piedrafita, Xavier Navarro, Josep E Esquerda, Jordi Calderó
Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with concomitant muscle denervation. MN excitability and vulnerability to disease are particularly regulated by cholinergic synaptic afferents (C-boutons), in which Sigma-1 receptor (Sig1R) is concentrated. Alterations in Sig1R have been associated with MN degeneration. Here, we investigated whether a chronic treatment with the Sig1R agonist PRE-084 was able to exert beneficial effects on SMA. We used a model of intermediate SMA, the Smn2B/- mouse, in which we performed a detailed characterization of the histopathological changes that occur throughout the disease...
May 14, 2018: Journal of Neuropathology and Experimental Neurology
Maura Massimino, Veronica Biassoni, Rosalba Miceli, Elisabetta Schiavello, Monika Warmuth-Metz, Piergiorgio Modena, Michela Casanova, Emilia Pecori, Felice Giangaspero, Manila Antonelli, Francesca Romana Buttarelli, Paolo Potepan, Bianca Pollo, Raffaele Nunziata, Filippo Spreafico, Marta Podda, Andrea Anichini, Carlo Alfredo Clerici, Iacopo Sardi, Loris De Cecco, Udo Bode, Ferdinand Bach, Lorenza Gandola
The therapeutic experience reported in the paper was conceived after the use of nimotuzumab and radiotherapy (BSCPED-05 international multicentric trial, EUDRACT 2005-003100-11) in 2009 when we decided to explore the activity of the same combination plus vinorelbine (see the paper for the rationale).
May 16, 2018: Journal of Neuro-oncology
Juan Pablo Fusco, Guillermo Pita, María José Pajares, Maria Pilar Andueza, Ana Patiño-García, Juan P de-Torres, Alfonso Gurpide, Javier Zulueta, Rosario Alonso, Nuria Alvarez, Ruben Pio, Ignacio Melero, Miguel F Sanmamed, Maria Rodriguez Ruiz, Ignacio Gil-Bazo, Jose María Lopez-Picazo, Ciro Casanova, Rebeca Baz Davila, Antonio Agudo, Maria Dolores Lozano, Alvaro Gonzalez, Nuria Sala, Eva Ardanaz, Javier Benitez, Luis Montuenga, Anna Gonzalez-Neira, Jose Luis Perez-Gracia
Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome-wide association study to characterize individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced non-small cell lung cancer (NSCLC), and we validated our results. We hypothesized that this strategy would enrich the frequencies of the alleles that contribute to the observed traits. We genotyped 2.37 million SNPs in 95 extreme phenotype individuals, that is: heavy smokers that either developed NSCLC at an early age (extreme cases); or did not present NSCLC at an advanced age (extreme controls), selected from a discovery set (n = 3631)...
May 15, 2018: Cancer Medicine
Alice Mayoly, Jean-Camille Mattei, Pierre Moullot, Charlotte Jaloux, Alexandre Rochwerger, Dominique Casanova, Baptiste Bertrand, Cécile Philandrianos
INTRODUCTION: The gastrocnemius muscular flap has already proven its efficiency for soft tissue coverage in cases of knee joint exposure. However, it may be too small to cover large defects and has not the same aesthetic and mechanical properties as normal skin. Perforator fasciocutaneous flaps have recently been described in knee joint coverage with good results as they replace skin by skin, but they can be hard to harvest. Gastrocnemius flaps can be easily harvested with a planned skin paddle designed over the chosen muscle...
May 14, 2018: Annals of Plastic Surgery
Adrien Casanova, Charline Blatché, Cecile Ferre, Hélène Martin, Daniel Gonzalez-Dunia, Liviu Nicu, Guilhem Larrieu
Despite significant progress, our knowledge of the functioning of the central nervous system still remains scarce to date. A better understanding of its behavior, in either normal or diseased conditions, goes through an increased knowledge of basic mechanisms involved in neuronal function, including at the single cell level. This has motivated significant efforts for the development of miniaturized sensing devices to monitor neuronal activity with high spatial and signal resolution. One of the main challenges remaining to be addressed in this domain is, however, the ability to create in vitro spatially-ordered neuronal networks at low density with a precise control of the cell location, to ensure proper monitoring of the activity of a defined set of neurons...
May 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Thierry Acafou Yapi, Zana Adama Ouattara, Jean Brice Boti, Zanahi Félix Tonzibo, Mathieu Paoli, Ange Bighelli, Joseph Casanova, Félix Tomi
The composition of Enantia polycarpa Engler & Diels leaf essential oil has been investigated for the first time using a combination of chromatographic and spectroscopic techniques. The compositions of 52 leaf essential oil samples have been subjected to statistical analysis, hierarchical cluster analysis (HCA) and principal component analysis (PCA). Four groups were differentiated, whose compositions were dominated by β-elemene and germacrene B (Group III, 22/52 samples); germacrene D (Group I, 16/52 samples); β-cubebene (Group IV, 8/52 samples) and by germacrene B and germacrene D (Group II, 6/52 samples)...
May 13, 2018: Chemistry & Biodiversity
L Grau-Guinea, C Pérez-Enríquez, G García-Escobar, C Arrondo-Elizarán, B Pereira-Cutiño, M Florido-Santiago, J Piqué-Candini, A Planas, M Paez, J Peña-Casanova, G Sánchez-Benavides
INTRODUCTION: The Free and Cued Selective Reminding Test (FCSRT) is widely used for the assessment of verbal episodic memory, mainly in patients with Alzheimer disease. A Spanish version of the FCSRT and normative data were developed within the NEURONORMA project. Availability of alternative, equivalent versions is useful for following patients up in clinical settings. This study aimed to develop an alternative version of the original FCSRT (version B) and to study its equivalence to the original Spanish test (version A), and its performance in a sample of healthy individuals, in order to develop reference data...
May 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Ana Amorós-Pérez, Laura Cano-Casanova, Mohammed Ouzzine, Mónica Rufete-Beneite, Aroldo José Romero-Anaya, María Ángeles Lillo-Ródenas, Ángel Linares-Solano
In the present manuscript, the preparation of spherical activated carbons (SACs) with suitable adsorption properties and high mechanical strength is reported, taking advantage of the retention of the spherical shape by the raw precursors. An easy procedure (carbonization followed by CO₂ activation) has been applied over a selection of three natural seeds, with a well-defined spherical shape and thermal stability: Rhamnus alaternus (RA), Osyris lanceolate (OL), and Canna indica (CI). After the carbonization-activation procedures, RA and CI, maintained their original spherical shapes and integrity, although a reduction in diameter around 48% and 25%, respectively, was observed...
May 10, 2018: Materials
Robert Meertens, Francesco Casanova, Karen M Knapp, Clare Thorn, William David Strain
A range of technologies using near infrared (NIR) light have shown promise at providing real time measurements of haemodynamic markers in bone tissue in vivo, an exciting prospect given existing difficulties in measuring haemodynamics in bone tissue. This systematic review aimed to evaluate the evidence for this potential use of NIR systems, establishing their potential as a research tool in this field. Major electronic databases including MEDLINE and EMBASE were searched using pre-planned search strategies with broad scope for any in vivo use of NIR technologies in human bone tissue...
May 4, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Elizabeth Córdoba-Lanús, Carlos Cabrera-López, Sara Cazorla-Rivero, M Cristo Rodríguez-Pérez, Armando Aguirre-Jaime, Bartolomé Celli, Ciro Casanova
BACKGROUND: Cross-sectional and longitudinal studies describe shorter telomeres in patients with chronic obstructive pulmonary disease (COPD) compared to matched non-COPD controls, but the relationship is confounded by tobacco consumption. We hypothesized that telomere shortening would be similar between non-smoking and smoking individuals with airflow limitation and shorter than non-obstructed controls. METHODS: Telomere length (T/S) was measured by qPCR in blood leukocytes of 80 non-smoking patients and 80 age-matched smokers with airflow limitation...
May 2018: Respiratory Medicine
Ramon Casanova, Santiago Saldana, Michael W Lutz, Brenda L Plassman, Maragatha Kuchibhatla, Kathleen M Hayden
Objectives: Genetic risks for cognitive decline are not modifiable; however their relative importance compared to modifiable factors is unclear. We used machine learning to evaluate modifiable and genetic risk factors for Alzheimer's disease(AD), to predict cognitive decline. Methods: Health and Retirement Study participants, aged 65-90, with DNA and >2 cognitive evaluations, were included (n=7,142). Predictors included age, body mass index, gender, education, APOE ε4, CVD, hypertension, diabetes, stroke, neighborhood socio-economic status(NSES), and AD risk genes...
April 27, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Stefano Signoroni, Laura Veneroni, Paola Gaggiotti, Carlo Alfredo Clerici, Michela Casanova, Tullio Proserpio, Matteo Silva, Maura Massimino, Andrea Ferrari
No abstract text is available yet for this article.
March 1, 2018: Tumori
Jiannan Kang, Erjuan Cai, Junxia Han, Zhen Tong, Xin Li, Estate M Sokhadze, Manuel F Casanova, Gaoxiang Ouyang, Xiaoli Li
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder which affects the developmental trajectory in several behavioral domains, including impairments of social communication, cognitive and language abilities. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, and it was used for modulating the brain disorders. In this paper, we enrolled 13 ASD children (11 males and 2 females; mean ± SD age: 6.5 ± 1.7 years) to participate in our trial. Each patient received 10 treatments over the dorsolateral prefrontal cortex (DLPFC) once every 2 days...
2018: Frontiers in Neuroscience
Quentin B Vincent, Aziz Belkadi, Cindy Fayard, Estelle Marion, Ambroise Adeye, Marie-Françoise Ardant, Christian R Johnson, Didier Agossadou, Lazaro Lorenzo, Julien Guergnon, Christine Bole-Feysot, Jeremy Manry, Patrick Nitschké, Ioannis Theodorou, Jean-Laurent Casanova, Laurent Marsollier, Annick Chauty, Laurent Abel, Alexandre Alcaïs
Buruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neglected tropical disease caused by Mycobacterium ulcerans. We report the clinical description and extensive genetic analysis of a consanguineous family from Benin comprising two cases of unusually severe non-ulcerative BU. The index case was the most severe of over 2,000 BU cases treated at the Centre de Dépistage et de Traitement de la Lèpre et de l'Ulcère de Buruli, Pobe, Benin, since its opening in 2003. The infection spread to all limbs with PCR-confirmed skin, bone and joint infections...
April 30, 2018: PLoS Neglected Tropical Diseases
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