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https://www.readbyqxmd.com/read/29144422/atypical-processing-of-novel-distracters-in-a-visual-oddball-task-in-autism-spectrum-disorder
#1
Estate M Sokhadze, Eva V Lamina, Emily L Casanova, Desmond P Kelly, Ioan Opris, Irma Khachidze, Manuel F Casanova
Several studies have shown that children with autism spectrum disorder (ASD) show abnormalities in P3b to targets in standard oddball tasks. The present study employed a three-stimulus visual oddball task with novel distracters that analyzed event-related potentials (ERP) to both target and non-target items at frontal and parietal sites. The task tested the hypothesis that children with autism are abnormally orienting attention to distracters probably due to impaired habituation to novelty. We predicted a lower selectivity in early ERPs to target, frequent non-target, and rare distracters...
November 16, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/29135512/cytokeratin-profile-of-basal-cell-carcinomas-according-to-the-degree-of-sun-exposure-and-to-the-anatomical-localization
#2
Ma Reyes García-de-la-Fuente, Maria Santacana, Joan Valls, Felip Vilardell, José Manuel Fernández Armenteros, Ramon Pujol, Eloi Gari, Josep Manel Casanova
Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non-sun-exposed areas, including hairless regions, was evaluated. The authors have observed that CK7 expression in BCC is associated with the anatomical localization of the tumor and its sun-exposition, but not with other factors such as histological subtype...
November 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29128761/inborn-errors-of-immunity-underlying-fungal-diseases-in-otherwise-healthy-individuals
#3
REVIEW
Juan Li, Donald C Vinh, Jean-Laurent Casanova, Anne Puel
It has been estimated that there are at least 1.5 million fungal species, mostly present in the environment, but only a few of these fungi cause human disease. Most fungal diseases are self-healing and benign, but some are chronic or life-threatening. Acquired and inherited defects of immunity, including breaches of mucocutaneous barriers and circulating leukocyte deficiencies, account for most severe modern-day mycoses. Other types of infection typically accompany these fungal infections. More rarely, severe fungal diseases can strike otherwise healthy individuals...
November 9, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29126879/mechanical-stretch-increases-l-type-calcium-channel-stability-in-cardiomyocytes-through-a-polycystin-1-akt-dependent-mechanism
#4
A Córdova-Casanova, I Olmedo, J A Riquelme, G Barrientos, G Sánchez, T G Gillette, S Lavandero, M Chiong, P Donoso, Z Pedrozo
The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC regulation are available, but only a few examine LTCC protein stability. Polycystin-1 (PC1) is a mechanosensor that regulates heart contractility and is involved in mechanical stretch-induced cardiac hypertrophy. PC1 was originally described as an unconventional Gi/o protein-coupled receptor in renal cells...
November 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29112976/calcein-pi-as-an-early-apoptotic-feature-in-leishmania
#5
Louise Basmaciyan, Nadine Azas, Magali Casanova
Although leishmaniases are responsible for high morbidity and mortality all over the world, no really satisfying treatment exists. Furthermore, the corresponding parasite Leishmania undergoes a very characteristic form of programmed cell death. Indeed, different stimuli can induce morphological and biochemical apoptotic-like features. However, the key proteins involved in mammal apoptosis, such as caspases and death receptors, are not encoded in the genome of this parasite. Currently, little is known about Leishmania apoptosis, notably owing to the lack of specific tools for programmed cell death analysis in these parasites...
2017: PloS One
https://www.readbyqxmd.com/read/29110009/theoretical-design-of-conjugated-diradicaloids-as-singlet-fission-sensitizers-quinones-and-methylene-derivatives
#6
Diego López-Carballeira, David Casanova, Fernando Ruipérez
The electronic structures of 206 carbonyls and methylene derivatives based on conjugated cyclic hydrocarbons are computationally studied in this work using theoretical methods of quantum chemistry. The singlet open-shell nature of the ground state and its influence on the low-lying excited states is analyzed for 90 carbonyl (quinone, Q), 90 methylene (quinone dimethide, QDM) and 26 carbonyl-methylene (quinone methide, QM) mixed derivatives in the pursuit of new promising candidates for singlet fission sensitizers...
November 7, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29104240/elliptic-fourier-analysis-in-the-study-of-the-male-genitalia-to-discriminate-three-macrolophus-species-hemiptera-miridae
#7
A M Jauset, E Edo-Tena, P M Parés-Casanova, C Castañé, N Agustí, O Alomar
Within the genus Macrolophus (Heteroptera: Miridae), the species M. costalis (Fieber), M. melanotoma (Costa) and M. pygmaeus (Rambur) are present in the Mediterranean region on a wide variety of plant species. While M. costalis can easily be separated from the other two by the black tip at the scutellum, M. pygmaeus and M. melanotoma are cryptic species, extremely similar to one another in external traits, which has resulted in misidentifications. M. pygmaeus is an efficient biological control agent, both in greenhouse and field crops...
November 1, 2017: Insects
https://www.readbyqxmd.com/read/29100287/nedd9-an-independent-good-prognostic-factor-in-intermediate-risk-acute-myeloid-leukemia-patients
#8
Victor Pallarès, Montserrat Hoyos, M Carmen Chillón, Eva Barragán, M Isabel Prieto Conde, Marta Llop, María Virtudes Céspedes, Josep F Nomdedeu, Salut Brunet, Miguel Ángel Sanz, Marcos González-Díaz, Jorge Sierra, Isolda Casanova, Ramon Mangues
Intermediate-risk acute myeloid leukemia (IR-AML) is the largest subgroup of AML patients and is highly heterogeneous. Whereas adverse and favourable risk patients have well-established treatment protocols, IR-AML patients have not. It is, therefore, crucial to find novel factors that stratify this subgroup to implement risk-adapted strategies. The CAS (Crk-associated substrate) adaptor protein family regulates cell proliferation, survival, migration and adhesion. Despite its association with metastatic dissemination and prognosis of different solid tumors, the role of these proteins in hematological malignancies has been scarcely evaluated...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099607/comparison-of-2017-and-2015-global-initiative-for-obstructive-lung-disease-impact-on-grouping-and-outcomes
#9
Carlos Cabrera López, Ciro Casanova Macario, José María Marín Trigo, Juan P de-Torres, Rebeca Sicilia Torres, Jesús María González, Francesca Polverino, Miguel Divo, Victor Pinto Plata, Javier J Zulueta, Bartolomé Celli
INTRODUCTION: The GOLD document has modified the grading system directing pharmacotherapy. But how this relates to the previous one of 2015 and to comorbidities, hospitalizations and mortality risk is unknown. METHODS: We prospectively enrolled and followed for a mean of 5 years, 819 COPD patients (84% male) in clinics in Spain and the United States. We determined anthropometrics, lung function (FEV1%), dyspnea score (mMRC), ambulatory and hospital exacerbations, the BODE and Charlson indexes...
November 3, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29098627/exercise-training-and-epigenetic-regulation-multilevel-modification-and-regulation-of-gene-expression
#10
Ursula Paula Renó Soci, Stephano Freitas Soares Melo, João Lucas Penteado Gomes, André Casanova Silveira, Clara Nóbrega, Edilamar Menezes de Oliveira
Exercise training elicits acute and adaptive long term changes in human physiology that mediate the improvement of performance and health state. The responses are integrative and orchestrated by several mechanisms, as gene expression. Gene expression is essential to construct the adaptation of the biological system to exercise training, since there are molecular processes mediating oxidative and non-oxidative metabolism, angiogenesis, cardiac and skeletal myofiber hypertrophy, and other processes that leads to a greater physiological status...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29097431/a-simple-algorithm-for-the-identification-of-clinical-copd-phenotypes
#11
Pierre-Régis Burgel, Jean-Louis Paillasseur, Wim Janssens, Jacques Piquet, Gerben Ter Riet, Judith Garcia-Aymerich, Borja Cosio, Per Bakke, Milo A Puhan, Arnulf Langhammer, Inmaculada Alfageme, Pere Almagro, Julio Ancochea, Bartolome R Celli, Ciro Casanova, Juan P de-Torres, Marc Decramer, Andrés Echazarreta, Cristobal Esteban, Rosa Mar Gomez Punter, MeiLan K Han, Ane Johannessen, Bernhard Kaiser, Bernd Lamprecht, Peter Lange, Linda Leivseth, Jose M Marin, Francis Martin, Pablo Martinez-Camblor, Marc Miravitlles, Toru Oga, Ana Sofia Ramírez, Don D Sin, Patricia Sobradillo, Juan J Soler-Cataluña, Alice M Turner, Francisco Javier Verdu Rivera, Joan B Soriano, Nicolas Roche
This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses.Data from 2409 COPD patients of French/Belgian COPD cohorts were analysed using cluster analysis resulting in the identification of subgroups, for which clinical relevance was determined by comparing 3-year all-cause mortality. Classification and regression trees (CARTs) were used to develop an algorithm for allocating patients to these subgroups...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29094224/primary-metastatic-osteosarcoma-results-of-a-prospective-study-in-children-given-chemotherapy-and-interleukin-2
#12
Cristina Meazza, Graziella Cefalo, Maura Massimino, Primo Daolio, Ugo Pastorino, Paolo Scanagatta, Carlo Morosi, Marta Podda, Andrea Ferrari, Monica Terenziani, Filippo Spreafico, Michela Casanova, Antonina Parafioriti, Paola Collini, Lorenza Gandola, Stefano Bastoni, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Roberto Luksch
To improve the poor prognosis for children with metastatic osteosarcoma (OS), interleukin-2 (IL-2) was added to the standard treatment due to its capacity to activate lymphocytes and differentiate lymphocyte subsets into lymphokine-activated killer (LAK) cells that are capable of recognizing and killing various tumor cells. This study concerns a cohort of unselected patients aged < 18 years with metastatic OS, who were treated with IL-2, high-dose methotrexate, doxorubicin, cisplatin, ifosfamide, LAK reinfusion, and surgery, between 1995 and 2010...
November 1, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29082727/mechanisms-of-resistance-to-daptomycin-in-staphylococcus-aureus
#13
REVIEW
N Gómez Casanova, M Siller Ruiz, J L Muñoz Bellido
Daptomycin is a cyclic lipopeptide active against multidrug-resistant Gram-positives, including methicillin-resistant Staphylococcus aureus (MRSA) and S. aureus with reduced susceptibility to vancomycin. It is 4-8 fold as active as vancomycin against methicillin-susceptible S. aureus (MSSA) and MRSA, and retains most of this activity against S. aureus with reduced susceptibility to vancomycin. The mechanism of action of daptomycin is not fully understood. Daptomycin binds to the bacterial cytoplasmic membrane, leading to depolarization due to the loss of potassium ions from the cytoplasm...
October 25, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29082505/long-term-effect-of-intensive-lifestyle-intervention-on-cerebral-blood-flow
#14
Mark A Espeland, Jose A Luchsinger, Rebecca H Neiberg, Owen Carmichael, Paul J Laurienti, Xavier Pi-Sunyer, Rena R Wing, Delilah Cook, Edward Horton, Ramon Casanova, Kirk Erickson, R Nick Bryan
OBJECTIVES: To determine whether long-term behavioral intervention targeting weight loss through increased physical activity and reduced caloric intake would alter cerebral blood flow (CBF) in individuals with type 2 diabetes mellitus. DESIGN: Postrandomization assessment of CBF. SETTING: Action for Health in Diabetes multicenter randomized controlled clinical trial. PARTICIPANTS: Individuals with type 2 diabetes mellitus who were overweight or obese and aged 45 to 76 (N = 310)...
October 30, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29078226/soft-tissue-coverage-in-distal-lower-extremity-open-fractures-comparison-of-free-anterolateral-thigh-and-free-latissimus-dorsi-flaps
#15
Cécile Philandrianos, Pierre Moullot, André M Gay, Baptiste Bertrand, Régis Legré, Nathalie Kerfant, Dominique Casanova
No abstract text is available yet for this article.
October 27, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29077186/laser-assisted-in-situ-keratomileusis-with-optimized-fast-repetition-and-cyclotorsion-control-excimer-laser-to-treat-hyperopic-astigmatism-with-high-cylinder
#16
Jorge L Alió Del Barrio, Mauro Tiveron, Ana B Plaza-Puche, María A Amesty, Laura Casanova, María J García, Jorge L Alió
PURPOSE: To evaluate the visual outcomes after femtosecond laser-assisted laser in situ keratomileusis (LASIK) surgery to correct primary compound hyperopic astigmatism with high cylinder using a fast repetition rate excimer laser platform with optimized aspheric profiles and cyclotorsion control. METHODS: Eyes with primary simple or compound hyperopic astigmatism and a cylinder power ≥3.00 D had uneventful femtosecond laser-assisted LASIK with a fast repetition rate excimer laser ablation, aspheric profiles, and cyclotorsion control...
October 18, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29076964/lysine-methylation-signaling-in-pancreatic-cancer
#17
Gaël S Roth, Alexandre G Casanova, Nathanaël Lemonnier, Nicolas Reynoird
PURPOSE OF REVIEW: Despite better knowledge of its genetic basis, pancreatic cancer is still highly lethal with very few therapeutic options. In this review, we discuss the potential impact of epigenetic therapies, focusing on lysine methylation signaling and its implication in pancreatic cancer. RECENT FINDINGS: Protein lysine methylation, a key mechanism of posttranslational modifications of histone proteins, has emerged as a major cell signaling mechanism regulating physiologic and pathologic processes including cancer...
October 25, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29067258/serum-25-hydroxyvitamin-d-but-not-dietary-vitamin-d-intake-is-associated-with-hemoglobin-in-women-of-reproductive-age-in-rural-northern-vietnam
#18
Ellen S Michalski, Phuong H Nguyen, Ines Gonzalez-Casanova, Son V Nguyen, Reynaldo Martorell, Vin Tangpricha, Usha Ramakrishnan
BACKGROUND AND OBJECTIVES: Hypovitaminosis D and anemia are both prevalent in Vietnam, and low vitamin D status may be a risk factor for anemia. This study aimed to 1) describe vitamin D intake and its determinants, and 2) examine the associations of vitamin D intake and serum 25(OH)D concentrations with hemoglobin and anemia. METHODS AND STUDY DESIGN: We used data from the baseline survey of a pre-conceptual micronutrient supplementation trial in women of reproductive age (WRA) in Thai Nguyen, Vietnam (N = 4961)...
June 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29066743/cytoplasmic-cyclin-d1-controls-the-migration-and-invasiveness-of-mantle-lymphoma-cells
#19
Simon Body, Anna Esteve-Arenys, Hadjer Miloudi, Clara Recasens-Zorzo, Guergana Tchakarska, Alexandra Moros, Sophie Bustany, Anna Vidal-Crespo, Vanina Rodriguez, Régis Lavigne, Emmanuelle Com, Isolda Casanova, Ramón Mangues, Oliver Weigert, Alejandra Sanjuan-Pla, Pablo Menéndez, Bénédicte Marcq, Jean-Michel Picquenot, Patricia Pérez-Galán, Fabrice Jardin, Gaël Roué, Brigitte Sola
Mantle cell lymphoma (MCL) is a hematologic neoplasm characterised by the t(11;14)(q13;q32) translocation leading to aberrant cyclin D1 expression. The cell functions of cyclin D1 depend on its partners and/or subcellular distribution, resulting in different oncogenic properties. We observed the accumulation of cyclin D1 in the cytoplasm of a subset of MCL cell lines and primary cells. In primary cells, this cytoplasmic distribution was correlated with a more frequent blastoid phenotype. We performed immunoprecipitation assays and mass spectrometry on enriched cytosolic fractions from two cell lines...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29058912/quantifying-the-selective-modification-of-au-111-facets-via-electrochemical-and-electroless-treatments-for-manipulating-gold-nanorod-surface-composition
#20
Elizabeth A Fisher, Kaylyn K Leung, Jannu Casanova-Moreno, Tamiko Masuda, Jeff Young, Dan Bizzotto
Manipulating the composition of a mixed alkylthiol self-assembled monolayer (SAM) modified gold surface using both electrochemical and electroless methods is demonstrated. Through the use of fluorophore labeled thiolated DNA and in situ fluorescence microscopy with a gold single crystal bead electrode, a procedure was developed to study and quantify the selective desorption of an alkylthiolate SAM. This method enabled a self-consistent measurement of the removal of the SAM from the 111 surface compared to the 100 surface region at various potentials...
November 1, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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