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https://www.readbyqxmd.com/read/28088491/toxicogenetic-study-of-persea-americana-fruit-pulp-oil-and-its-effect-on-genomic-instability
#1
Heloiza Diniz Nicolella, Francisco Rinaldi Neto, Mariana Beltrame Corrêa, Danillo Henrique Lopes, Edilaura Nunes Rondon, Luiz Felipe Ribeiro Dos Santos, Pollyanna Francielli de Oliveira, Jaqueline Lopes Damasceno, Nathália Oliveira Acésio, Izabel Cristina Casanova Turatti, Marcos Gomide Tozatti, Wilson Roberto Cunha, Ricardo Andrade Furtado, Denise Crispim Tavares
Persea americana Mill., commonly known as avocado, is a tree native to Central America that is widely used as a food source and for the treatment of diseases. This plant has various biological properties such as analgesic, anti-inflammatory and total cholesterol-lowering activity. In view of its pharmacological potential, we conducted a toxicogenetic study of the fruit pulp oil of P. americana (PAO) and investigated its influence on genotoxicity induced by methyl methanesulfonate (MMS) and doxorubicin. V79 cells and Swiss mice were used for the assays...
January 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28087227/a-novel-kindred-with-inherited-stat2-deficiency-and-severe-viral-illness
#2
Leen Moens, Lien Van Eyck, Dirk Jochmans, Tania Mitera, Glynis Frans, Xavier Bossuyt, Patrick Matthys, Johan Neyts, Michael Ciancanelli, Shen-Ying Zhang, Rik Gijsbers, Jean-Laurent Casanova, Stephanie Boisson-Dupuis, Isabelle Meyts, Adrian Liston
No abstract text is available yet for this article.
January 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28069966/inherited-human-irak-1-deficiency-selectively-impairs-tlr-signaling-in-fibroblasts
#3
Erika Della Mina, Alessandro Borghesi, Hao Zhou, Salim Bougarn, Sabri Boughorbel, Laura Israel, Ilaria Meloni, Maya Chrabieh, Yun Ling, Yuval Itan, Alessandra Renieri, Iolanda Mazzucchelli, Sabrina Basso, Piero Pavone, Raffaele Falsaperla, Roberto Ciccone, Rosa Maria Cerbo, Mauro Stronati, Capucine Picard, Orsetta Zuffardi, Laurent Abel, Damien Chaussabel, Nico Marr, Xiaoxia Li, Jean-Laurent Casanova, Anne Puel
Most members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) families transduce signals via a canonical pathway involving the MyD88 adapter and the interleukin-1 receptor-associated kinase (IRAK) complex. This complex contains four molecules, including at least two (IRAK-1 and IRAK-4) active kinases. In mice and humans, deficiencies of IRAK-4 or MyD88 abolish most TLR (except for TLR3 and some TLR4) and IL-1R signaling in both leukocytes and fibroblasts. TLR and IL-1R responses are weak but not abolished in mice lacking IRAK-1, whereas the role of IRAK-1 in humans remains unclear...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28065942/neuregulin-1-erbb-module-in-c-bouton-synapses-on-somatic-motor-neurons-molecular-compartmentation-and-response-to-peripheral-nerve-injury
#4
Anna Casanovas, Sara Salvany, Víctor Lahoz, Olga Tarabal, Lídia Piedrafita, Raimundo Sabater, Sara Hernández, Jordi Calderó, Josep E Esquerda
The electric activity of lower motor neurons (MNs) appears to play a role in determining cell-vulnerability in MN diseases. MN excitability is modulated by cholinergic inputs through C-type synaptic boutons, which display an endoplasmic reticulum-related subsurface cistern (SSC) adjacent to the postsynaptic membrane. Besides cholinergic molecules, a constellation of proteins involved in different signal-transduction pathways are clustered at C-type synaptic sites (M2 muscarinic receptors, Kv2.1 potassium channels, Ca(2+) activated K(+) [SK] channels, and sigma-1 receptors [S1R]), but their collective functional significance so far remains unknown...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039920/seed-removal-in-a-tropical-north-american-desert-an-evaluation-of-pre-and-post-dispersal-seed-removal-in-stenocereus-stellatus
#5
R Álvarez-Espino, L Ríos-Casanova, H Godínez-Álvarez
To determine seed removal influence on seed populations, we need to quantify pre- and post-dispersal seed removal. Several studies have quantified seed removal in temperate American deserts, but few studies have been performed in tropical deserts. These studies have only quantified pre- or post-dispersal seed removal, thus underestimating the influence of seed removal. We evaluated pre- and post-dispersal seed removal in the columnar cactus Stenocereus stellatus in a Mexican tropical desert. We performed selective exclosure experiments to estimate percentage of seeds removed by ants, birds, and rodents during the pre- and post-dispersal phases...
December 31, 2016: Plant Biology
https://www.readbyqxmd.com/read/28036121/study-of-the-anti-jcv-antibody-levels-in-a-spanish-multiple-sclerosis-cohort
#6
María I Dominguez-Mozo, Macarena Rus, Jose L Santiago, Guillermo Izquierdo, Ignacio Casanova, Victoria Galan, M Angel Garcia-Martinez, Ana M Arias-Leal, Marta García-Montojo, Silvia Pérez-Pérez, Rafael Arroyo, Roberto Alvarez-Lafuente
One of the risk factor to develop progressive multifocal leukoencephalopathy (PML) among natalizumab-treated patients is the presence and high levels of anti-JCV antibodies. Our purpose was to test the association of different clinical and demographic variables with the presence and levels of anti-JCV antibodies in a Spanish cohort of multiple sclerosis (MS) patients during natalizumab treatment MATERIALS AND METHODS: All MS patients from two hospitals with at least one measure of the anti-JCV antibodies levels (2011-2014) were recruited, among them two PML cases...
December 30, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28012461/ten-years-in-the-dump-an-updated-review-of-the-miocene-primate-bearing-localities-from-abocador-de-can-mata-ne-iberian-peninsula
#7
David M Alba, Isaac Casanovas-Vilar, Miguel Garcés, Josep M Robles
More than ten years of paleontological fieldwork during the enlargement of the Can Mata Landfill (Abocador de Can Mata [ACM]), in els Hostalets de Pierola (Vallès-Penedès Basin, NE Iberian Peninsula) led to the recovery of >60,000 Miocene vertebrate remains. The huge sampling effort (due to continuous surveillance of heavy machinery digging activity, coupled with manual excavation and screen-washing of sediments) enabled generally rare faunal elements such as pliopithecoid and hominoid primates to be found...
January 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28011864/combined-immunodeficiency-and-epstein-barr-virus-induced-b-cell-malignancy-in-humans-with-inherited-cd70-deficiency
#8
Hassan Abolhassani, Emily S J Edwards, Aydan Ikinciogullari, Huie Jing, Stephan Borte, Marcus Buggert, Likun Du, Mami Matsuda-Lennikov, Rosa Romano, Rozina Caridha, Sangeeta Bade, Yu Zhang, Juliet Frederiksen, Mingyan Fang, Sevgi Kostel Bal, Sule Haskologlu, Figen Dogu, Nurdan Tacyildiz, Helen F Matthews, Joshua J McElwee, Emma Gostick, David A Price, Umaimainthan Palendira, Asghar Aghamohammadi, Bertrand Boisson, Nima Rezaei, Annika C Karlsson, Michael J Lenardo, Jean-Laurent Casanova, Lennart Hammarström, Stuart G Tangye, Helen C Su, Qiang Pan-Hammarström
In this study, we describe four patients from two unrelated families of different ethnicities with a primary immunodeficiency, predominantly manifesting as susceptibility to Epstein-Barr virus (EBV)-related diseases. Three patients presented with EBV-associated Hodgkin's lymphoma and hypogammaglobulinemia; one also had severe varicella infection. The fourth had viral encephalitis during infancy. Homozygous frameshift or in-frame deletions in CD70 in these patients abolished either CD70 surface expression or binding to its cognate receptor CD27...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28011069/alanine-scanning-mutagenesis-of-human-signal-transducer-and-activator-of-transcription-1-to-estimate-loss-or-gain-of-function-variants
#9
Reiko Kagawa, Ryoji Fujiki, Miyuki Tsumura, Sonoko Sakata, Shiho Nishimura, Yuval Itan, Xiao-Fei Kong, Zenichiro Kato, Hidenori Ohnishi, Osamu Hirata, Satoshi Saito, Maiko Ikeda, Jamila El Baghdadi, Aziz Bousfiha, Kaori Fujiwara, Matias Oleastro, Judith Yancoski, Laura Perez, Silvia Danielian, Fatima Ailal, Hidetoshi Takada, Toshiro Hara, Anne Puel, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Osamu Ohara, Satoshi Okada, Masao Kobayashi
BACKGROUND: Germline heterozygous mutations in human signal transducer and activator of transcription 1 (STAT1) can cause loss of function (LOF), as in patients with Mendelian susceptibility to mycobacterial diseases, or gain of function (GOF), as in patients with chronic mucocutaneous candidiasis. LOF and GOF mutations are equally rare and can affect the same domains of STAT1, especially the coiled-coil domain (CCD) and DNA-binding domain (DBD). Moreover, 6% of patients with chronic mucocutaneous candidiasis with a GOF STAT1 mutation have mycobacterial disease, obscuring the functional significance of the identified STAT1 mutations...
December 14, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28009887/responses-of-crepis-japonica-induced-by-supplemental-blue-light-and-uv-a-radiation
#10
L F da S Constantino, L B Dos S Nascimento, L M Casanova, N Dos S Moreira, E A Menezes, R L Esteves, S S Costa, E S Tavares
Crepis japonica (L.) D.C. (Asteraceae), a weed with antioxidant, antiallergenic, antiviral and antitumor properties displays both medicinal properties and nutritional value. This study aims to assess the effects of a supplementation of blue light and UV-A radiation on the growth, leaf anatomical structure and phenolic profile of the aerial parts of Crepis japonica. Plants were grown under two light treatments: W (control - white light), W + B (white light supplemented with blue light) and W + UV-A (white light supplemented with UV-A radiation)...
December 23, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28009426/-christmas-balls-a-christmas-carol-by-the-adolescent-cancer-patients-of-the-milan-youth-project
#11
Andrea Ferrari, Stefano Signoroni, Matteo Silva, Paola Gaggiotti, Laura Veneroni, Chiara Magni, Michela Casanova, Stefano Chiaravalli, Mirko Capelletti, Pietro Lapidari, Carlo Alfredo Clerici, Maura Massimino
The Youth Project is a program developed at the Pediatric Oncology Unit at the Istituto Nazionale Tumori in Milan, dedicated to adolescents and young adults with cancer. Among its various goals, the Youth Project organizes structured creative activities with the support of professionals, with the objective of offering young people a new way to express their hopes and fears. This article describes a project centered around music: patients created a Christmas carol with the help of musicians and authors. The adolescents explained with their own words the meaning of the lyrics, telling the story of a Christmas spent in a cancer hospital ward...
December 19, 2016: Tumori
https://www.readbyqxmd.com/read/28000588/active-tuberculosis-patients-have-high-levels-of-iga-anti-alpha-crystallin-and-isocitrate-lyase-proteins
#12
M Talavera-Paulín, L García-Morales, B P Ruíz-Sánchez, Á D Caamal-Ley, A Hernández-Solis, E Ramírez-Casanova, R Cicero-Sabido, C Espitia, C Helguera-Repetto, J A González-Y-Merchand, R Flores-Mejía, S Estrada-Parra, I Estrada-García, R Chacón-Salinas, I Wong-Baeza, J Serafín-López
SETTING: Mexico City, Mexico. OBJECTIVE: To identify proteins synthetised by Mycobacterium tuberculosis in hypoxic culture, which resemble more closely a granuloma environment than aerobic culture, and to determine if they are recognised by antibodies from patients with active pulmonary tuberculosis (PTB). DESIGN: Soluble extracts from M. tuberculosis H37Rv cultured under aerobic or hypoxic conditions were analysed using two-dimensional polyacrylamide gel electrophoresis, and proteins over-expressed under hypoxia were identified by mass spectrometry...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000584/utility-of-the-quantiferon%C3%A2-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#13
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Guérin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27999557/playing-pong-together-emergent-coordination-in-a-doubles-interception-task
#14
Niek H Benerink, Frank T J M Zaal, Remy Casanova, Nathalie Bonnardel, Reinoud J Bootsma
In this contribution we set out to study how a team of two players coordinated their actions so as to intercept an approaching ball. Adopting a doubles-pong task, six teams of two participants each intercepted balls moving downward across a screen toward an interception axis by laterally displacing participant-controlled on-screen paddles. With collisions between paddles resulting in unsuccessful interception, on each trial participants had to decide amongst them who would intercept the ball and who would not...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27996281/il-12r%C3%AE-1-defect-presenting-with-massive-intraabdominal-lymphadenopathy-due-to-mycobacterium-intracellulare-a-case-report
#15
Eda Kepenekli Kadayifci, Ayşe Karaaslan, Serkan Atici, Gülşen Akkoç, Safa Bariş, Nurhayat Yakut, Sevliya Öcal Demir, Orhan Kaya KÖksalan, Ahmet Soysal, Caroline Deswarte, Jacinta Bustamante, Jean-Laurent Casanova, Mustafa Bakir
Infections due to non-tuberculous mycobacteria species are problematic for people who have immundeficiency. Mendelian Susceptibility to Mycobacterial Diseases (MSMD) defines a group of genetic defects affecting cellular interactions and IFN-γ pathway. Patients with MSMD may present with disseminated infection due to Bacillus Calmette-Guerin vaccine strain, Mycobacterium tuberculosis complex, environmental NTM or Salmonella species. Atypical mycobacterial infections and deficient granuloma/giant-cell formation are important clues for MSMD especially in patients with the history of parental consanguineous marriage...
December 12, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27993403/biopsy-of-the-sentinel-node-in-lung-cancer
#16
Naia Uribe-Etxebarria Lugariza-Aresti, Ramón Barceló Galíndez, Joaquín Pac Ferrer, Jaime Méndez Martín, Jose Genollá Subirats, Juan Casanova Viudez
INTRODUCTION AND OBJECTIVE: Mediastinal lymph node involvement can be understaged in cases of lung cancer (up to 20% in stage i). Sentinel node detection is a standard technique recommended in breast cancer and melanoma action guidelines, and could also be useful in cases of lung cancer. MATERIAL AND METHODS: Considering the detection of the sentinel node in non-small cell lung cancer (NSCLC) as feasible, a prospective cohort study was carried out on 48 patients with resectable NSCLC, using the intraoperative injection of colloid sulphate technetium-99...
December 16, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27991928/stem-cell-like-transcriptional-reprogramming-mediates-metastatic-resistance-to-mtor-inhibition
#17
F Mateo, E J Arenas, H Aguilar, J Serra-Musach, G Ruiz de Garibay, J Boni, M Maicas, S Du, F Iorio, C Herranz-Ors, A Islam, X Prado, A Llorente, A Petit, A Vidal, I Català, T Soler, G Venturas, A Rojo-Sebastian, H Serra, D Cuadras, I Blanco, J Lozano, F Canals, A M Sieuwerts, V de Weerd, M P Look, S Puertas, N García, A S Perkins, N Bonifaci, M Skowron, L Gómez-Baldó, V Hernández, A Martínez-Aranda, M Martínez-Iniesta, X Serrat, J Cerón, J Brunet, M P Barretina, M Gil, C Falo, A Fernández, I Morilla, S Pernas, M J Plà, X Andreu, M A Seguí, R Ballester, E Castellà, M Nellist, S Morales, J Valls, A Velasco, X Matias-Guiu, A Figueras, J V Sánchez-Mut, M Sánchez-Céspedes, A Cordero, J Gómez-Miragaya, L Palomero, A Gómez, T F Gajewski, E E W Cohen, M Jesiotr, L Bodnar, M Quintela-Fandino, N López-Bigas, R Valdés-Mas, X S Puente, F Viñals, O Casanovas, M Graupera, J Hernández-Losa, S Ramón Y Cajal, L García-Alonso, J Saez-Rodriguez, M Esteller, A Sierra, N Martín-Martín, A Matheu, A Carracedo, E González-Suárez, M Nanjundan, J Cortés, C Lázaro, M D Odero, J W M Martens, G Moreno-Bueno, M H Barcellos-Hoff, A Villanueva, R R Gomis, M A Pujana
Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mTOR inhibition. This cancer feature is driven by EVI1 and SOX9. EVI1 functionally cooperates with and positively regulates SOX9, and promotes the transcriptional upregulation of key mTOR pathway components (REHB and RAPTOR) and of lung metastasis mediators (FSCN1 and SPARC)...
December 19, 2016: Oncogene
https://www.readbyqxmd.com/read/27989768/xact-noncoding-rna-competes-with-xist-in-the-control-of-x-chromosome-activity-during-human-early-development
#18
Céline Vallot, Catherine Patrat, Amanda J Collier, Christophe Huret, Miguel Casanova, Tharvesh M Liyakat Ali, Matteo Tosolini, Nelly Frydman, Edith Heard, Peter J Rugg-Gunn, Claire Rougeulle
Sex chromosome dosage compensation is essential in most metazoans, but the developmental timing and underlying mechanisms vary significantly, even among placental mammals. Here we identify human-specific mechanisms regulating X chromosome activity in early embryonic development. Single-cell RNA sequencing and imaging revealed co-activation and accumulation of the long noncoding RNAs (lncRNAs) XACT and XIST on active X chromosomes in both early human pre-implantation embryos and naive human embryonic stem cells...
January 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/27984517/transplant-surgery-training-in-europe-board-exams-in-transplant-surgery-and-the-accreditation-of-transplant-centers
#19
Jacopo Romagnoli, Daniel Casanova, Vassilios Papalois
No abstract text is available yet for this article.
December 14, 2016: Transplantation
https://www.readbyqxmd.com/read/27982626/experimental-investigation-of-the-collective-raman-scattering-of-multiple-laser-beams-in-inhomogeneous-plasmas
#20
S Depierreux, C Neuville, C Baccou, V Tassin, M Casanova, P-E Masson-Laborde, N Borisenko, A Orekhov, A Colaitis, A Debayle, G Duchateau, A Heron, S Huller, P Loiseau, P Nicolaï, D Pesme, C Riconda, G Tran, R Bahr, J Katz, C Stoeckl, W Seka, V Tikhonchuk, C Labaune
Experiments have been performed evidencing significant stimulated Raman sidescattering (SRS) at large angles from the density gradient. This was achieved in long scale-length high-temperature plasmas in which two beams couple to the same scattered electromagnetic wave further demonstrating for the first time this multiple-beam collective SRS interaction. The collective nature of the coupling and the amplification at large angles from the density gradient increase the global SRS losses and produce light scattered in novel directions out of the planes of incidence of the beams...
December 2, 2016: Physical Review Letters
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