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Aortic insufficiency

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https://www.readbyqxmd.com/read/29038882/etelcalcetide-a-novel-calcimimetic-prevents-vascular-calcification-in-a-rat-model-of-renal-insufficiency-with-secondary-hyperparathyroidism
#1
Longchuan Yu, James E Tomlinson, Shawn T Alexander, Kelly Hensley, Chun-Ya Han, Denise Dwyer, Marina Stolina, Charles Dean, William G Goodman, William G Richards, Xiaodong Li
Etelcalcetide, a novel peptide agonist of the calcium-sensing receptor, prevents vascular calcification in a rat model of renal insufficiency with secondary hyperparathyroidism. Vascular calcification occurs frequently in patients with chronic kidney disease (CKD) and is a consequence of impaired mineral homeostasis and secondary hyperparathyroidism (SHPT). Etelcalcetide substantially lowers parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) levels in SHPT patients on hemodialysis. This study compared the effects of etelcalcetide and paricalcitol on vascular calcification in rats with adenine-induced CKD and SHPT...
October 16, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29038418/two-reports-of-quadricuspid-aortic-valve-with-aortic-insufficiency
#2
Zahir Satti, Abdalla Ibrahim, Peter Kelly
We report two cases of a quadricuspid aortic valve with severe aortic incompetence. Both patients presented with dyspnea on exertion. Their physical examinations demonstrated wide pulse pressures with diastolic murmurs. Bedside transthoracic Doppler echocardiography revealed preserved left ventricular systolic function and possible quadricuspid aortic valve with severe aortic incompetence in both patients. We proceeded with transesophageal echocardiography that confirmed a quadricuspid aortic valve with severe aortic incompetence in both patients...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29022854/single-center-mid-term-experience-with-chimney-graft-technique-for-the-preservation-of-flow-to-the-supra-aortic-branches
#3
Robert Shahverdyan, Spyridon Mylonas, Michael Gawenda, Jan Brunkwall
Objectives To investigate the feasibility and the mid-term outcomes of the chimney-graft technique for the revascularization of supra-aortic branches in patients with thoracic aortic pathologies involving the aortic arch. Methods A retrospective analysis of a prospectively maintained database between January 2010 and July 2016 was performed. Primary endpoints were 30-day and overall mortality. Secondary endpoints were technical success, target vessel patency, stroke/transitory ischemic attack and type I/III endoleak rate...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28994816/the-aortic-ring-co-culture-assay-a-convenient-tool-to-assess-the-angiogenic-potential-of-mesenchymal-stromal-cells-in-vitro
#4
Farwah Iqbal, Yarden S Gratch, Peter Szaraz, Clifford L Librach
Angiogenesis is a complex, highly regulated process responsible for providing and maintaining adequate tissue perfusion. Insufficient vasculature maintenance and pathological malformations can result in severe ischemic diseases, while overly abundant vascular development is associated with cancer and inflammatory disorders. A promising form of pro-angiogenic therapy is the use of angiogenic cell sources, which can provide regulatory factors as well as physical support for newly developing vasculature. Mesenchymal Stromal Cells (MSCs) are extensively investigated candidates for vascular regeneration due to their paracrine effects and their ability to detect and home to ischemic or inflamed tissues...
September 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28994654/impact-of-concomitant-mitral-regurgitation-on-transvalvular-gradient-and-flow-in-severe-aortic-stenosis-a-systematic-ex-vivo-analysis-of-a-subentity-of-low-flow-low-gradient-aortic-stenosis
#5
Felix Katte, Marcus Franz, Christian Jung, Hans R Figulla, David M Leistner, Philipp Jakob, Barbara E Stähli, Daniel Kretzschmar, Alexander Lauten
AIMS: Evaluation of aortic stenosis(AS) is based on measurement of mean transvalvular gradient(MPG), flow velocity(vmax) and aortic valve area(AVA). Objective of the present study was to analyse the impact of systemic hemodynamic variables and concomitant mitral regurgitation(MR) on aortic MPG, vmax and AVA in severe AS. METHODS AND RESULTS: A pulsatile circulatory model was designed to study function and interdependence of stenotic aortic and insufficient mitral prosthetic valves (n=8; effective regurgitation orifice (EROA)<0...
October 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28994146/congenital-unruptured-aneurysm-of-sinus-of-valsalva-quadricuspid-aortic-valve-and-ascending-aortic-aneurysm-associated-with-genetic-leukoencephalopathy-in-an-infant-a-new-syndrome
#6
Elaheh Malakan Rad, Hamidreza Pouraliakbar
We report a 15-month-old female with unruptured noncoronary sinus of Valsalva anreurysm (SOVA) associated with quadricuspid aortic valve, ascending aortic aneurysm (AAA), moderate aortic insufficiency, mild mitral insufficiency, genetic leukoencepaholpathy, developmental delay and mild mixed aminoaciduria. She was referred for evaluation of a cardiac murmur. Initial echocardiographic examination showed the aneurysm as a round cyst in the right atrium which changed in size during systole and diastole. As to the best of our knowledge, this is the first report of association of SOVA, quadricuspid aortic valve, AAA and genetic leukoencephalopathy in an infant...
October 10, 2017: Echocardiography
https://www.readbyqxmd.com/read/28990342/post-tavr-aortogram-transform-it-into-a-modern-tool-for-prognosis-and-efficiency
#7
EDITORIAL
Pradeep K Yadav, Ian C Gilchrist
Video densitometry after aortography can provide objective assessment of aortic regurgitation post-transcatheter aortic valve replacement (TAVR) Contrast density ratio between the left ventricular outflow track and proximal aorta (LVOT-AR) of >0.17 suggests greater than mild aortic insufficiency and correlates with echo findings LVOT-AR of >0.17 is associated with higher 30-day and 1-year mortality.
October 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28983673/left-ventricular-outflow-tract-closure-during-lvad-implantation-2-cases-of-patients-supported-for-over-6%C3%A2-years
#8
Andre Critsinelis, Chitaru Kurihara, Masashi Kawabori, Tadahisa Sugiura, Andrew B Civitello, O H Frazier, Jeffrey A Morgan
We previously reported a series of 5 patients with advanced heart failure and aortic insufficiency (AI) who underwent concomitant left ventricular outflow tract (LVOT) closure at the time of continuous-flow left ventricular assist device (CF-LVAD) implantation. Although this technique of treating AI has been shown to be effective in the short term, its long-term durability has not been well studied. Here, we report the long-term outcomes of two patients with severe AI who underwent LVOT closure at the time of CF-LVAD implantation...
October 5, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28982503/clinical-outcomes-following-the-ross%C3%A2-procedure-in-adults-a-25-year-longitudinal-study
#9
Elisabeth Martin, Siamak Mohammadi, Frederic Jacques, Dimitri Kalavrouziotis, Pierre Voisine, Daniel Doyle, Jean Perron
BACKGROUND: Very few reports of long-term outcomes of patients who underwent the Ross procedure have been published. OBJECTIVES: The authors reviewed their 25-year experience with the Ross procedure with the aim of defining very-long-term survival and factors associated with Ross-related failure. METHODS: Between January 1990 and December 2014, the Ross procedure was performed in 310 adults (mean age 40.8 years) at a single institution. All patients were prospectively added to a dedicated cardiac surgery registry...
October 10, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28974341/bubr1-insufficiency-impairs-angiogenesis-in-aging-and-in-experimental-critical-limb-ischemic-mice
#10
Jun Okadome, Takuya Matsumoto, Keiji Yoshiya, Daisuke Matsuda, Kouji Tamada, Mitsuho Onimaru, Kaku Nakano, Kensuke Egashira, Yoshikazu Yonemitsu, Yoshihiko Maehara
OBJECTIVES: Budding uninhibited by benzimidazole-related 1 (BubR1), a cell cycle-related protein, is an essential component of the spindle checkpoint that regulates cell division. Mice in which BubR1 expression is reduced to 10% of the normal level display the phenotypic features of progeria. However, the role of BubR1 in vascular diseases and angiogenesis remains unknown. To investigate the influence of BubR1 on angiogenesis, we generated a low-null-BubR1-expressing (BubR1(L/-)) mouse strain with reduced BubR1 expression as low as 15% of the normal level without any abnormalities in appearance...
September 30, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28971577/development-of-quality-metrics-for-ambulatory-pediatric-cardiology-transposition-of-the-great-arteries-after-arterial-switch-operation
#11
Carissa M Baker-Smith, Karina Carlson, Jose Ettedgui, Takeshi Tsuda, K Anitha Jayakumar, Matthew Park, Nikola Tede, Karen Uzark, Craig Fleishman, David Connuck, Maggie Likes, Daniel J Penny
OBJECTIVE: To develop quality metrics (QMs) for the ambulatory care of patients with transposition of the great arteries following arterial switch operation (TGA/ASO). DESIGN: Under the auspices of the American College of Cardiology Adult Congenital and Pediatric Cardiology (ACPC) Steering committee, the TGA/ASO team generated candidate QMs related to TGA/ASO ambulatory care. Candidate QMs were submitted to the ACPC Steering Committee and were reviewed for validity and feasibility using individual expert panel member scoring according to the RAND-UCLA methodology...
October 2, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28968482/lymphadenectomy-for-the-management-of-endometrial-cancer
#12
REVIEW
Jonathan A Frost, Katie E Webster, Andrew Bryant, Jo Morrison
BACKGROUND: This is an update of a previous Cochrane review published in Issue 1, 2010 and updated in Issue 9, 2015. The role of lymphadenectomy in surgical management of endometrial cancer remains controversial. Lymph node metastases can be found in approximately 10% of women who before surgery are thought to have cancer confined to the womb. Removal of all pelvic and para-aortic lymph nodes (lymphadenectomy) at initial surgery has been widely advocated, and pelvic and para-aortic lymphadenectomy remains part of the FIGO (International Federation of Gynaecology and Obstetrics) staging system for endometrial cancer...
October 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28964424/hybrid-balloon-valvuloplasty-for-the-treatment-of-severe-congenital-aortic-valve-stenosis-in-infants
#13
Wen-Bin Ou-Yang, Shou-Jun Li, Yong-Quan Xie, Sheng-Shou Hu, Shou-Zheng Wang, Feng-Wen Zhang, Gai-Li Guo, Yao Liu, Kun-Jing Pang, Xiang-Bin Pan
BACKGROUND: Surgical or percutaneous interventional treatment of severe congenital aortic valve stenosis (CAS) in early infancy remains challenging. This single-center, retrospective study analyzed midterm outcomes of a hybrid balloon valvuloplasty procedure through the ascending aorta by way of median sternotomy, including cases with improved technique. METHODS: Included were 45 consecutive infants (aged <90 days) with CAS and selected for biventricular repair who underwent hybrid balloon valvuloplasty in a hybrid or ordinary operating room from October 2010 to March 2016...
September 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28960050/redo-root-replacement-using-the-ross-in-valsalva-technique
#14
Shakil Farid, Saadallah Tamer, Laurent de Kerchove, Gebrine El Khoury
The Ross procedure is an alternative option for young and middle-aged patients needing aortic valve replacement. We present an interesting case where the patient had a preexisting aortic homograft that was implanted because of previous infective endocarditis with aortic root abscess. The patient presented with biological degeneration of the homograft with resultant severe stenosis as well as insufficiency. We performed a redo root surgery to replace the homograft with the Ross procedure by using the autograft inclusion into a vascular graft technique...
August 4, 2017: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28954945/ischemic-tolerance-of-the-brain-and-spinal-cord-a-review
#15
Masatoshi Yunoki, Takahiro Kanda, Kenta Suzuki, Atsuhito Uneda, Koji Hirashita, Kimihiro Yoshino
Ischemic tolerance is an endogenous neuroprotective phenomenon induced by sublethal ischemia. Ischemic preconditioning (IPC), the first discovered form of ischemic tolerance, is widely seen in many species and in various organs including the brain and the spinal cord. Ischemic tolerance of the spinal cord is less familiar among neurosurgeons, although it has been reported from the viewpoint of preventing ischemic spinal cord injury during aortic surgery. It is important for neurosurgeons to have opportunities to see patients with spinal cord ischemia, and to understand ischemic tolerance of the spinal cord as well as the brain...
September 27, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28943011/early-reintervention-after-open-and-endovascular-abdominal-aortic-aneurysm-repair-is-associated-with-high-mortality
#16
Sarah E Deery, Thomas F X O'Donnell, Thomas C F Bodewes, Barbara A Dalebout, Alexander B Pothof, Katie E Shean, Jeremy D Darling, Marc L Schermerhorn
OBJECTIVE: Although reinterventions are generally considered more common after endovascular aneurysm repair (EVAR) than after open surgical repair (OSR), less is known about reintervention in the early postoperative period. Furthermore, there are few data regarding the impact of early reintervention on 30-day mortality. We sought to evaluate the rates and types of reintervention after abdominal aortic aneurysm (AAA) repair and the impact of reintervention on postoperative mortality. METHODS: The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) was queried from 2012 to 2014 for all intact, infrarenal AAA repairs...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28941287/addition-of-albumin-to-traditional-risk-score-improved-prediction-of-mortality-in-individuals-undergoing-transcatheter-aortic-valve-replacement
#17
Yoni Grossman, Israel M Barbash, Paul Fefer, Ilan Goldenberg, Anat Berkovitch, Ehud Regev, Noam Fink, Sagit Ben-Zekry, Yafim Brodov, Alexander Kogan, Victor Guetta, Ehud Raanani, Amit Segev
OBJECTIVES: The ability of the Society of Thoracic Surgeons (STS) and European System for Cardiac Operative Risk Evaluation (EuroSCORE)-2 scores to predict outcomes after transcatheter aortic valve replacement (TAVR) is insufficient. Frailty and serum albumin as a frailty marker were shown to correlate with prognosis after TAVR. We sought to evaluate the additive value of serum albumin to STS and EuroSCORE-2 scores to predict mortality in individuals undergoing TAVR. DESIGN: Retrospective analysis...
September 23, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28940557/skeletal-muscle-protein-accretion-rates-and-hindlimb-growth-are-reduced-in-late-gestation-intrauterine-growth-restricted-fetal-sheep
#18
Paul J Rozance, Laura Zastoupil, Stephanie R Wesolowski, David A Goldstrohm, Brittany Strahan, Melanie Cree-Green, Melinda Sheffield-Moore, Giacomo Meschia, William W Hay, Randall B Wilkening, Laura D Brown
Reduced skeletal muscle mass in the IUGR fetus persists into adulthood and may contribute to increased metabolic disease risk. To determine how placental insufficiency with reduced oxygen and nutrient supply to the fetus affects hindlimb blood flow, substrate uptake, and protein accretion rates in skeletal muscle, late gestation CON (n = 8) and IUGR (n = 13) fetal sheep were catheterized with aortic and femoral catheters and a flow transducer around the external iliac artery. Muscle protein kinetic rates were measured using isotopic tracers...
September 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28940406/congenital-aortic-valve-repair-using-cormatrix-%C3%A2-a-histologic-evaluation
#19
Michael Hofmann, Martin O Schmiady, Barbara E Burkhardt, Hitendu H Dave, Michael Hübler, Oliver Kretschmar, Peter K Bode
BACKGROUND: The reconstruction of heart valves provides substantial benefits, particularly in the pediatric population. We present our experience using decellularized extracellular matrix (dECM, CorMatrix(®) ) for aortic valve procedures. METHODS: We retrospectively reviewed the case histories of 6 patients (aged from 2 months - 14 years) who underwent surgery for severe aortic valve stenosis (n = 4) or regurgitation (n = 2). Aortic valve repair was performed on all patients using dECM as a leaflet replacement or leaflet extension...
September 22, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28935349/spinal-ischemia-in-thoracic-aortic-procedures-impact-of-radiculomedullary-artery-distribution
#20
Fabian A Kari, Karin Wittmann, Sonja Krause, Babak Saravi, Luisa Puttfarcken, Katharina Förster, Bartosz Rylski, Sven Maier, Ulrich Göbel, Matthias Siepe, Martin Czerny, Friedhelm Beyersdorf
BACKGROUND: The aim of this study was to assess the influence of thoracic anterior radiculomedullary artery (tARMA) distribution on spinal cord perfusion in a thoracic aortic surgical model. METHODS: Twenty-six pigs (34 ± 3 kg; study group, n = 20; sham group, n = 6) underwent ligation of the left subclavian artery and thoracic segmental arteries. End points were spinal cord perfusion pressure (SCPP), regional spinal cord blood flow (SCBF), and neurologic outcome with an observation time of 3 hours...
September 18, 2017: Annals of Thoracic Surgery
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