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https://www.readbyqxmd.com/read/29112315/reverse-double-inversion-recovery-improving-motion-robustness-of-cardiac-t2-weighted-dark-blood-turbo-spin-echo-sequence
#1
Chenxi Hu, Steffen Huber, Syed R Latif, Guido Santacana-Laffitte, Hamid R Mojibian, Lauren A Baldassarre, Dana C Peters
BACKGROUND: Cardiac dark-blood turbo spin-echo (TSE) imaging is sensitive to through-plane motion, resulting in myocardial signal reduction. PURPOSE: To propose and validate reverse double inversion-recovery (RDIR)-a dark-blood preparation with improved motion robustness for the cardiac dark-blood TSE sequence. STUDY TYPE: Prospective. POPULATION: Healthy volunteers (n = 10) and patients (n = 20). FIELD STRENGTH: 1...
November 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29079569/associations-of-nocturnal-blood-pressure-with-cognition-by-self-identified-race-in-middle-aged-and-older-adults-the-genoa-genetic-epidemiology-network-of-arteriopathy-study
#2
Yuichiro Yano, Kenneth R Butler, Michael E Hall, Gary L Schwartz, David S Knopman, Seth T Lirette, Daniel W Jones, James G Wilson, John E Hall, Adolfo Correa, Stephen T Turner, Thomas H Mosley
BACKGROUND: Whether the association of blood pressure (BP) during sleep (nocturnal BP) with cognition differs by race is unknown. METHODS AND RESULTS: Participants in the GENOA (Genetic Epidemiology Network of Arteriopathy) Study underwent ambulatory BP measurements, brain magnetic resonance imaging, and cognitive function testing (the Rey Auditory Verbal Learning Test, the Digit Symbol Substitution Task, and the Trail Making Test Part B) between 2000 and 2007. We examined multivariable linear regression models of the nocturnal BP-cognition association...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29071386/3d-fast-spin-echo-t1%C3%A2-black-blood-imaging-for-the-preoperative-detection-of-venous-sinus-invasion-by-meningioma-comparison-with-contrast-enhanced-mrv
#3
Dongdong Wang, Yiping Lu, Bo Yin, Mingyu Chen, Daoying Geng, Li Liu, Jianbo Wen, Ping Zhong, Yuan Li
OBJECTIVES: To prospectively evaluate the diagnostic value of 3D fast spin-echo (FSE) T1 black-blood magnetic resonance (MR) imaging (3D CUBE T1WI) in comparison with contrast-enhanced MR venography (CE-MRV) in the detection of sinus invasion by meningiomas. METHODS: In this study forty consecutive patients with suspected meningiomas adjacent to venous sinus underwent conventional MR imaging, CE-MRV and 3D CUBE T1WI scans. Images obtained by each technique were assessed independently by two neuroradiologists for (1) wall invasion and (2) lumen occlusion of the target venous sinus...
October 25, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28993449/visit-to-visit-blood-pressure-variability-in-young-adulthood-and-hippocampal-volume-and-integrity-at-middle-age-the-cardia-study-coronary-artery-risk-development-in-young-adults
#4
Yuichiro Yano, Jared P Reis, Deborah A Levine, R Nick Bryan, Anthony J Viera, Daichi Shimbo, Yacob G Tedla, Norrina B Allen, Pamela J Schreiner, Michael P Bancks, Stephen Sidney, Mark J Pletcher, Kiang Liu, Philip Greenland, Donald M Lloyd-Jones, Lenore J Launer
The aims of this study are to assess the relationships of visit-to-visit blood pressure (BP) variability in young adulthood to hippocampal volume and integrity at middle age. We used data over 8 examinations spanning 25 years collected in the CARDIA study (Coronary Artery Risk Development in Young Adults) of black and white adults (age, 18-30 years) started in 1985 to 1986. Visit-to-visit BP variability was defined as by SDBP and average real variability (ARVBP, defined as the absolute differences of BP between successive BP measurements)...
December 2017: Hypertension
https://www.readbyqxmd.com/read/28984339/a-unique-immunofluorescence-protocol-to-detect-protein-expression-in-vascular-tissues-tacking-a-long-standing-pathological-hitch
#5
Puneet Gandhi, Richa Khare
OBJECTIVE: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28971799/human-and-nonhuman-primate-meninges-harbor-lymphatic-vessels-that-can-be-visualized-noninvasively-by-mri
#6
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents...
October 3, 2017: ELife
https://www.readbyqxmd.com/read/28951848/successful-treatment-of-aureobasidium-pullulans-central-catheter-related-fungemia-and-septic-pulmonary-emboli
#7
Sanjay R Mehta, Scott Johns, Paul Stark, Joshua Fierer
INTRODUCTION: Aureobasidium pullulans is a saprophytic fungus that is widely distributed in the environment, and in the right host can be an opportunistic human pathogen. PRESENTATION OF CASE: A 66-year-old man with Crohn's disease with a single kidney, and requiring total parenteral nutrition via a Hickman catheter, was admitted with a 10-week history of progressive shortness of breath, fevers and weight loss. Chest imaging demonstrated new multifocal lung parenchymal opacities compatible with septic pulmonary emboli...
2017: IDCases
https://www.readbyqxmd.com/read/28884851/-bottom-up-in-situ-proteomic-differentiation-of-human-and-non-human-haemoglobins-for-forensic-purposes-by-matrix-assisted-laser-desorption-ionization-time-of-flight-tandem-mass-spectrometry
#8
S Kamanna, J Henry, N Voelcker, A Linacre, K P Kirkbride
RATIONALE: The detection and identification of human blood on crime-related items are of particular relevance to many investigations because shed blood can provide evidence of violent contact between individuals. However, for any detection and identification technique, specificity is a critical performance characteristic to assess; that is, whether the technique has the capability to differentiate between human blood (which usually is of relevance to a criminal investigation) and non-human blood (which usually would not be associated with a crime but may be detected incidentally)...
November 30, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28867671/the-development-and-optimisation-of-3d-black-blood-r2-mapping-of-the-carotid-artery-wall
#9
Jianmin Yuan, Martin J Graves, Andrew J Patterson, Andrew N Priest, Pascal P R Ruetten, Ammara Usman, Jonathan H Gillard
PURPOSE: To develop and optimise a 3D black-blood R2* mapping sequence for imaging the carotid artery wall, using optimal blood suppression and k-space view ordering. METHODS: Two different blood suppression preparation methods were used; Delay Alternating with Nutation for Tailored Excitation (DANTE) and improved Motion Sensitive Driven Equilibrium (iMSDE) were each combined with a three-dimensional (3D) multi-echo Fast Spoiled GRadient echo (ME-FSPGR) readout...
December 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28858894/multiple-sclerosis-improved-detection-of-active-cerebral-lesions-with-3-dimensional-t1-black-blood-magnetic-resonance-imaging-compared-with-conventional-3-dimensional-t1-gre-imaging
#10
Nora N Sommer, Tobias Saam, Eva Coppenrath, Hendrik Kooijman, Tania Kümpfel, Maximilian Patzig, Sebastian E Beyer, Wieland H Sommer, Maximilian F Reiser, Birgit Ertl-Wagner, Karla M Treitl
OBJECTIVES: The aim of this study was to assess the diagnostic accuracy of a modified high-resolution whole-brain three-dimensional T1-weighted black-blood sequence (T1-weighted modified volumetric isotropic turbo spin echo acquisition [T1-mVISTA]) in comparison to a standard three-dimensional T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) sequence for detection of contrast-enhancing cerebral lesions in patients with relapsing-remitting multiple sclerosis (MS). MATERIALS AND METHODS: After institutional review board approval and informed consent, 22 patients (8 men; aged 31...
August 30, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28832083/a-unique-immunofluorescence-protocol-to-detect-protein-expression-in-vascular-tissues-tacking-a-long-standing-pathological-hitch
#11
Puneet Gandhi, Richa Khare
OBJECTIVE: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28814675/retinal-amyloid-pathology-and-proof-of-concept-imaging-trial-in-alzheimer-s-disease
#12
Yosef Koronyo, David Biggs, Ernesto Barron, David S Boyer, Joel A Pearlman, William J Au, Shawn J Kile, Austin Blanco, Dieu-Trang Fuchs, Adeel Ashfaq, Sally Frautschy, Gregory M Cole, Carol A Miller, David R Hinton, Steven R Verdooner, Keith L Black, Maya Koronyo-Hamaoui
BACKGROUND: Noninvasive detection of Alzheimer's disease (AD) with high specificity and sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective intervention. AD patients exhibit a myriad of retinal pathologies, including hallmark amyloid β-protein (Aβ) deposits. METHODS: Burden, distribution, cellular layer, and structure of retinal Aβ plaques were analyzed in flat mounts and cross sections of definite AD patients and controls (n = 37)...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28766810/evaluation-of-carotid-atherosclerotic-plaque-surface-characteristics-utilizing-simultaneous-noncontrast-angiography-and-intraplaque-hemorrhage-snap-technique
#13
Shuo Chen, Huilin Zhao, Jifan Li, Zechen Zhou, Rui Li, Niranjan Balu, Chun Yuan, Huijun Chen, Xihai Zhao
PURPOSE: To evaluate the feasibility of the Simultaneous Noncontrast Angiography and intraPlaque hemorrhage (SNAP) technique in identification of carotid plaque surface characteristics compared with the conventional multicontrast vessel wall imaging protocol. MATERIALS AND METHODS: Thirty symptomatic patients with carotid plaque were recruited and underwent carotid artery magnetic resonance imaging (MRI) (3.0T) using a conventional multicontrast protocol and SNAP sequence...
August 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28722267/simultaneous-bright-and-black-blood-whole-heart-mri-for-noncontrast-enhanced-coronary-lumen-and-thrombus-visualization
#14
Giulia Ginami, Radhouene Neji, Alkystis Phinikaridou, John Whitaker, René M Botnar, Claudia Prieto
PURPOSE: To develop a 3D whole-heart Bright-blood and black-blOOd phase SensiTive (BOOST) inversion recovery sequence for simultaneous noncontrast enhanced coronary lumen and thrombus/hemorrhage visualization. METHODS: The proposed sequence alternates the acquisition of two bright-blood datasets preceded by different preparatory pulses to obtain variations in blood/myocardium contrast, which then are combined in a phase-sensitive inversion recovery (PSIR)-like reconstruction to obtain a third, coregistered, black-blood dataset...
July 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28681479/enhancement-of-automated-blood-flow-estimates-enable-from-arterial-spin-labeled-mri
#15
Zahra Shirzadi, Bojana Stefanovic, Michael A Chappell, Joel Ramirez, Graeme Schwindt, Mario Masellis, Sandra E Black, Bradley J MacIntosh
PURPOSE: To validate a multiparametric automated algorithm-ENhancement of Automated Blood fLow Estimates (ENABLE)-that identifies useful and poor arterial spin-labeled (ASL) difference images in multiple postlabeling delay (PLD) acquisitions and thereby improve clinical ASL. MATERIALS AND METHODS: ENABLE is a sort/check algorithm that uses a linear combination of ASL quality features. ENABLE uses simulations to determine quality weighting factors based on an unconstrained nonlinear optimization...
July 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28679324/breath-hold-black-blood-t1rho-mapping-improves-liver-t1rho-quantification-in-healthy-volunteers
#16
Yì Xiáng J Wáng, Min Deng, Gladys G Lo, Dong Liang, Jing Yuan, Weitian Chen
Background Recent researches suggest that T1rho may be a non-invasive and quantitative technique for detecting and grading liver fibrosis. Purpose To compare a multi-breath-hold bright-blood fast gradient echo (GRE) imaging and a single breath-hold single-shot fast spin echo (FSE) imaging with black-blood effect for liver parenchyma T1rho measurement and to study liver physiological T1rho value in healthy volunteers. Material and Methods The institutional Ethics Committee approved this study. 28 healthy participants (18 men, 10 women; age = 29...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28653214/three-dimensional-black-blood-multi-contrast-carotid-imaging-using-compressed-sensing-a-repeatability-study
#17
Jianmin Yuan, Ammara Usman, Scott A Reid, Kevin F King, Andrew J Patterson, Jonathan H Gillard, Martin J Graves
OBJECTIVE: The purpose of this work is to evaluate the repeatability of a compressed sensing (CS) accelerated multi-contrast carotid protocol at 3 T. MATERIALS AND METHODS: Twelve volunteers and eight patients with carotid disease were scanned on a 3 T MRI scanner using a CS accelerated 3-D black-blood multi-contrast protocol which comprises T 1w, T 2w and PDw without CS, and with a CS factor of 1.5 and 2.0. The volunteers were scanned twice, the lumen/wall area and wall thickness were measured for each scan...
June 26, 2017: Magma
https://www.readbyqxmd.com/read/28629953/3d-black-blood-mr-angiography-of-the-carotid-arteries-a-simple-sequence-for-plaque-hemorrhage-and-stenosis-evaluation
#18
Monica Sigovan, Clément Bidet, Sébastien Bros, Loic Boussel, Laura Mechtouff, Philip M Robson, Zahi A Fayad, Antoine Millon, Philippe Douek
OBJECTIVES: To evaluate the diagnostic performance of a new three-dimensional T1-weighted turbo-spin-echo sequence (3D T1-w TSE) compared to 3D contrast-enhanced angiography (CE-MRA) for stenosis measurement and compared to 2D T1-w TSE for intra-plaque hemorrhage (IPH) detection. METHODS: Eighty three patients underwent carotid MRI, using a new elliptic-centric phase encoding T1-weighted 3D TSE sequence in addition to the clinical protocol. Two observers evaluated image quality, presence of flow artifacts, and presence of intra-plaque hemorrhage, and computed the NASCET degree of stenosis for CE-MRA and for the new sequence...
October 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28629561/multi-contrast-and-three-dimensional-assessment-of-the-aortic-wall-using-3t-mri
#19
Thomas Wehrum, Iulius Dragonu, Christoph Strecker, Jürgen Hennig, Andreas Harloff
OBJECTIVES: To develop a 3D-multi-contrast MRI protocol allowing for high resolution imaging of the wall and of atheroma in the thoracic aorta. METHODS: Eleven healthy volunteers and eleven acute stroke patients with aortic plaques detected by TEE underwent MRI at 3T. The MRI-protocol consisted of a T1w-bright-blood, a T2w- and a PDw-black-blood sequence (spatial resolution=1.15mm(3)). Image quality was assessed by two blinded investigators using a 3-point score and intra- and inter-rater agreement was tested...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28626998/large-coverage-black-bright-blood-interleaved-imaging-sequence-labbi-for-3d-dynamic-contrast-enhanced-mri-of-vessel-wall
#20
Haikun Qi, Feng Huang, Zechen Zhou, Peter Koken, Niranjan Balu, Bida Zhang, Chun Yuan, Huijun Chen
PURPOSE: To propose a large coverage black-bright blood interleaved imaging sequence (LaBBI) for 3D dynamic contrast-enhanced MRI (DCE-MRI) of the vessel wall. METHODS: LaBBI consists of a 3D black-blood stack-of-stars golden angle radial acquisition with high spatial resolution for vessel wall imaging and a 2D bright-blood Cartesian acquisition with high temporal resolution for arterial input function estimation. The two acquisitions were performed in an interleaved fashion within a single scan...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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