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https://www.readbyqxmd.com/read/29307167/clinical-value-of-18f-fdg-pet-ct-and-3d-black-blood-3t-mri-for-the-diagnosis-of-large-vessel-vasculitis-and-single-organ-vasculitis-of-the-aorta
#1
Vera Wenter, Nora N Sommer, Hendrik Kooijman, Stefan Maurus, Marcus Treitl, Michael Czihal, Claudia Dechant, Marcus Unterrainer, Nathalie L Albert, Karla M Treitl
BACKGROUND: We aimed to investigate the clinical value of a 3D-T1w turbo-spin-echo (TSE) sequence and [18F]fluorodeoxyglucose positron emission tomography / computed tomography ([18F]FDG- PET/CT) for the diagnosis of active large vessel vasculitis (LVV) and single-organ vasculitis (SOV) of the aorta. METHODS: 24 patients with suspected vasculitis who underwent MRI and PET/CT were retrospectively evaluated. MRI was analyzed for concentric contrast enhancement and wall thickening, and flow artifact intensity (4-point-scales)...
January 2, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29284494/ferumoxytol-enhanced-black-blood-cardiovascular-magnetic-resonance-imaging
#2
Kim-Lien Nguyen, Eun-Ah Park, Takegawa Yoshida, Peng Hu, J Paul Finn
BACKGROUND: Bright-blood and black-blood cardiovascular magnetic resonance (CMR) techniques are frequently employed together during a clinical exam because of their complementary features. While valuable, existing black-blood CMR approaches are flow dependent and prone to failure. We aim to assess the effectiveness and reliability of ferumoxytol enhanced (FE) Half-Fourier Single-shot Turbo Spin-echo (HASTE) imaging without magnetization preparation pulses to yield uniform intra-luminal blood signal suppression by comparing FE-HASTE with pre-ferumoxytol HASTE imaging...
December 28, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29259930/intravascular-large-b-cell-lymphoma-with-multi-organ-failure-presenting-as-a-pancreatic-mass-a-case-with-atypical-presentation-and-definite-diagnosis-postmortem
#3
Faisal Mahmudul Huq Ronny, Margaret Ann Black, Arnaldo A Arbini
Intravascular large B-cell lymphoma (IVLBCL) is a very rare extra nodal lymphoma that tends to proliferate within small blood vessels, particularly capillaries and postcapillary venules while sparing the organ parenchyma. The cause of its affinity for the vascular bed remains unknown. Because of its rarity and unremarkable clinical presentation, a timely diagnosis of IVLBCL is very challenging. Here, we describe a case of IVLBCL presenting as pancreatic mass that was ultimately diagnosed at autopsy. A 71-year-old Caucasian female presented with a 3-month history of fatigue, abdominal pain, and weight loss...
October 2017: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29241024/age-and-gender-associated-liver-physiological-t1rho-dynamics-demonstrated-with-a-clinically-applicable-single-breathhold-acquisition
#4
Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony W L Kwok, Eric K W Liu, Weitian Chen
To understand women's and men's physiological ranges of liver T1rho relaxation time measured with a single breathhold black blood sequence, this healthy volunteer study was conducted in 62 women (mean age, 38.9 y; range, 18-75 y) and 34 men (mean age, 44.7 y; range, 24-80 y). Approval from the institutional ethics committee was obtained. Magnetic resonance imaging was performed with a 3.0T scanner with six spin-lock times of 0, 10, 20, 25, 35, and 50 ms and a single breathhold of 12 s per slice acquisition...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29217492/the-potential-role-of-ideal-mri-for-identification-of-lipids-and-hemorrhage-in-carotid-artery-plaques
#5
Faisal Khosa, Rachel E Clough, Xiaoen Wang, Ananth J Madhuranthakam, Robert L Greenman
Hemorrhage and lipid deposits contribute to instability in atherosclerotic plaques. Unstable carotid artery plaques can lead to cerebral ischemic events. While MRI studies have shown the ability to identify plaque components, the identification of hemorrhage and lipids has proven to be problematic. The purpose of this study was to quantitatively evaluate the potential of the MRI fat/water separation method known as iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL) to complement and improve existing methods for the identification of hemorrhage and lipids in carotid artery plaques...
December 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29209856/accelerated-whole-brain-intracranial-vessel-wall-imaging-using-black-blood-fast-spin-echo-with-compressed-sensing-cs-space
#6
Chengcheng Zhu, Bing Tian, Luguang Chen, Laura Eisenmenger, Esther Raithel, Christoph Forman, Sinyeob Ahn, Gerhard Laub, Qi Liu, Jianping Lu, Jing Liu, Christopher Hess, David Saloner
OBJECTIVE: Develop and optimize an accelerated, high-resolution (0.5 mm isotropic) 3D black blood MRI technique to reduce scan time for whole-brain intracranial vessel wall imaging. MATERIALS AND METHODS: A 3D accelerated T1-weighted fast-spin-echo prototype sequence using compressed sensing (CS-SPACE) was developed at 3T. Both the acquisition [echo train length (ETL), under-sampling factor] and reconstruction parameters (regularization parameter, number of iterations) were first optimized in 5 healthy volunteers...
December 5, 2017: Magma
https://www.readbyqxmd.com/read/29178893/3d-whole-heart-phase-sensitive-inversion-recovery-cmr-for-simultaneous-black-blood-late-gadolinium-enhancement-and-bright-blood-coronary-cmr-angiography
#7
Giulia Ginami, Radhouene Neji, Imran Rashid, Amedeo Chiribiri, Tevfik F Ismail, René M Botnar, Claudia Prieto
BACKGROUND: Phase sensitive inversion recovery (PSIR) applied to late gadolinium enhancement (LGE) imaging is widely used in clinical practice. However, conventional 2D PSIR LGE sequences provide sub-optimal contrast between scar tissue and blood pool, rendering the detection of subendocardial infarcts and scar segmentation challenging. Furthermore, the acquisition of a low flip angle reference image doubles the acquisition time without providing any additional diagnostic information...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29112315/reverse-double-inversion-recovery-improving-motion-robustness-of-cardiac-t2-weighted-dark-blood-turbo-spin-echo-sequence
#8
Chenxi Hu, Steffen Huber, Syed R Latif, Guido Santacana-Laffitte, Hamid R Mojibian, Lauren A Baldassarre, Dana C Peters
BACKGROUND: Cardiac dark-blood turbo spin-echo (TSE) imaging is sensitive to through-plane motion, resulting in myocardial signal reduction. PURPOSE: To propose and validate reverse double inversion-recovery (RDIR)-a dark-blood preparation with improved motion robustness for the cardiac dark-blood TSE sequence. STUDY TYPE: Prospective. POPULATION: Healthy volunteers (n = 10) and patients (n = 20). FIELD STRENGTH: 1...
November 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29079569/associations-of-nocturnal-blood-pressure-with-cognition-by-self-identified-race-in-middle-aged-and-older-adults-the-genoa-genetic-epidemiology-network-of-arteriopathy-study
#9
Yuichiro Yano, Kenneth R Butler, Michael E Hall, Gary L Schwartz, David S Knopman, Seth T Lirette, Daniel W Jones, James G Wilson, John E Hall, Adolfo Correa, Stephen T Turner, Thomas H Mosley
BACKGROUND: Whether the association of blood pressure (BP) during sleep (nocturnal BP) with cognition differs by race is unknown. METHODS AND RESULTS: Participants in the GENOA (Genetic Epidemiology Network of Arteriopathy) Study underwent ambulatory BP measurements, brain magnetic resonance imaging, and cognitive function testing (the Rey Auditory Verbal Learning Test, the Digit Symbol Substitution Task, and the Trail Making Test Part B) between 2000 and 2007. We examined multivariable linear regression models of the nocturnal BP-cognition association...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29071386/3d-fast-spin-echo-t1%C3%A2-black-blood-imaging-for-the-preoperative-detection-of-venous-sinus-invasion-by-meningioma-comparison-with-contrast-enhanced-mrv
#10
Dongdong Wang, Yiping Lu, Bo Yin, Mingyu Chen, Daoying Geng, Li Liu, Jianbo Wen, Ping Zhong, Yuan Li
OBJECTIVES: To prospectively evaluate the diagnostic value of 3D fast spin-echo (FSE) T1 black-blood magnetic resonance (MR) imaging (3D CUBE T1WI) in comparison with contrast-enhanced MR venography (CE-MRV) in the detection of sinus invasion by meningiomas. METHODS: In this study forty consecutive patients with suspected meningiomas adjacent to venous sinus underwent conventional MR imaging, CE-MRV and 3D CUBE T1WI scans. Images obtained by each technique were assessed independently by two neuroradiologists for (1) wall invasion and (2) lumen occlusion of the target venous sinus...
October 25, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28993449/visit-to-visit-blood-pressure-variability-in-young-adulthood-and-hippocampal-volume-and-integrity-at-middle-age-the-cardia-study-coronary-artery-risk-development-in-young-adults
#11
Yuichiro Yano, Jared P Reis, Deborah A Levine, R Nick Bryan, Anthony J Viera, Daichi Shimbo, Yacob G Tedla, Norrina B Allen, Pamela J Schreiner, Michael P Bancks, Stephen Sidney, Mark J Pletcher, Kiang Liu, Philip Greenland, Donald M Lloyd-Jones, Lenore J Launer
The aims of this study are to assess the relationships of visit-to-visit blood pressure (BP) variability in young adulthood to hippocampal volume and integrity at middle age. We used data over 8 examinations spanning 25 years collected in the CARDIA study (Coronary Artery Risk Development in Young Adults) of black and white adults (age, 18-30 years) started in 1985 to 1986. Visit-to-visit BP variability was defined as by SDBP and average real variability (ARVBP, defined as the absolute differences of BP between successive BP measurements)...
December 2017: Hypertension
https://www.readbyqxmd.com/read/28984339/a-unique-immunofluorescence-protocol-to-detect-protein-expression-in-vascular-tissues-tacking-a-long-standing-pathological-hitch
#12
Puneet Gandhi, Richa Khare
OBJECTIVE: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28971799/human-and-nonhuman-primate-meninges-harbor-lymphatic-vessels-that-can-be-visualized-noninvasively-by-mri
#13
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents...
October 3, 2017: ELife
https://www.readbyqxmd.com/read/28951848/successful-treatment-of-aureobasidium-pullulans-central-catheter-related-fungemia-and-septic-pulmonary-emboli
#14
Sanjay R Mehta, Scott Johns, Paul Stark, Joshua Fierer
INTRODUCTION: Aureobasidium pullulans is a saprophytic fungus that is widely distributed in the environment, and in the right host can be an opportunistic human pathogen. PRESENTATION OF CASE: A 66-year-old man with Crohn's disease with a single kidney, and requiring total parenteral nutrition via a Hickman catheter, was admitted with a 10-week history of progressive shortness of breath, fevers and weight loss. Chest imaging demonstrated new multifocal lung parenchymal opacities compatible with septic pulmonary emboli...
2017: IDCases
https://www.readbyqxmd.com/read/28884851/-bottom-up-in-situ-proteomic-differentiation-of-human-and-non-human-haemoglobins-for-forensic-purposes-by-matrix-assisted-laser-desorption-ionization-time-of-flight-tandem-mass-spectrometry
#15
S Kamanna, J Henry, N Voelcker, A Linacre, K P Kirkbride
RATIONALE: The detection and identification of human blood on crime-related items are of particular relevance to many investigations because shed blood can provide evidence of violent contact between individuals. However, for any detection and identification technique, specificity is a critical performance characteristic to assess; that is, whether the technique has the capability to differentiate between human blood (which usually is of relevance to a criminal investigation) and non-human blood (which usually would not be associated with a crime but may be detected incidentally)...
November 30, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28867671/the-development-and-optimisation-of-3d-black-blood-r2-mapping-of-the-carotid-artery-wall
#16
Jianmin Yuan, Martin J Graves, Andrew J Patterson, Andrew N Priest, Pascal P R Ruetten, Ammara Usman, Jonathan H Gillard
PURPOSE: To develop and optimise a 3D black-blood R2* mapping sequence for imaging the carotid artery wall, using optimal blood suppression and k-space view ordering. METHODS: Two different blood suppression preparation methods were used; Delay Alternating with Nutation for Tailored Excitation (DANTE) and improved Motion Sensitive Driven Equilibrium (iMSDE) were each combined with a three-dimensional (3D) multi-echo Fast Spoiled GRadient echo (ME-FSPGR) readout...
December 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28858894/multiple-sclerosis-improved-detection-of-active-cerebral-lesions-with-3-dimensional-t1-black-blood-magnetic-resonance-imaging-compared-with-conventional-3-dimensional-t1-gre-imaging
#17
Nora N Sommer, Tobias Saam, Eva Coppenrath, Hendrik Kooijman, Tania Kümpfel, Maximilian Patzig, Sebastian E Beyer, Wieland H Sommer, Maximilian F Reiser, Birgit Ertl-Wagner, Karla M Treitl
OBJECTIVES: The aim of this study was to assess the diagnostic accuracy of a modified high-resolution whole-brain three-dimensional T1-weighted black-blood sequence (T1-weighted modified volumetric isotropic turbo spin echo acquisition [T1-mVISTA]) in comparison to a standard three-dimensional T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) sequence for detection of contrast-enhancing cerebral lesions in patients with relapsing-remitting multiple sclerosis (MS). MATERIALS AND METHODS: After institutional review board approval and informed consent, 22 patients (8 men; aged 31...
August 30, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28832083/a-unique-immunofluorescence-protocol-to-detect-protein-expression-in-vascular-tissues-tacking-a-long-standing-pathological-hitch
#18
Puneet Gandhi, Richa Khare
OBJECTIVE: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28814675/retinal-amyloid-pathology-and-proof-of-concept-imaging-trial-in-alzheimer-s-disease
#19
Yosef Koronyo, David Biggs, Ernesto Barron, David S Boyer, Joel A Pearlman, William J Au, Shawn J Kile, Austin Blanco, Dieu-Trang Fuchs, Adeel Ashfaq, Sally Frautschy, Gregory M Cole, Carol A Miller, David R Hinton, Steven R Verdooner, Keith L Black, Maya Koronyo-Hamaoui
BACKGROUND: Noninvasive detection of Alzheimer's disease (AD) with high specificity and sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective intervention. AD patients exhibit a myriad of retinal pathologies, including hallmark amyloid β-protein (Aβ) deposits. METHODS: Burden, distribution, cellular layer, and structure of retinal Aβ plaques were analyzed in flat mounts and cross sections of definite AD patients and controls (n = 37)...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28766810/evaluation-of-carotid-atherosclerotic-plaque-surface-characteristics-utilizing-simultaneous-noncontrast-angiography-and-intraplaque-hemorrhage-snap-technique
#20
Shuo Chen, Huilin Zhao, Jifan Li, Zechen Zhou, Rui Li, Niranjan Balu, Chun Yuan, Huijun Chen, Xihai Zhao
PURPOSE: To evaluate the feasibility of the Simultaneous Noncontrast Angiography and intraPlaque hemorrhage (SNAP) technique in identification of carotid plaque surface characteristics compared with the conventional multicontrast vessel wall imaging protocol. MATERIALS AND METHODS: Thirty symptomatic patients with carotid plaque were recruited and underwent carotid artery magnetic resonance imaging (MRI) (3.0T) using a conventional multicontrast protocol and SNAP sequence...
August 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
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