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https://www.readbyqxmd.com/read/29764897/diagnostic-yield-of-genetic-testing-in-young-athletes-with-t-wave-inversion
#1
Nabeel Sheikh, Michael Papadakis, Mathew Wilson, Aneil Malhotra, Carmen Adamuz, Tessa Homfray, Lorenzo Monserrat, Elijah R Behr, Sanjay Sharma
Background -T-wave inversion (TWI) is common in patients with cardiomyopathy. However, up to 25% of athletes of African/Afro-Caribbean descent (black athletes) and 5% of white athletes also have TWI of unclear clinical significance despite comprehensive clinical evaluation and long-term follow-up. The aim of this study was to determine the diagnostic yield from genetic testing, beyond clinical evaluation, when investigating athletes with TWI. Methods -We investigated 50 consecutive asymptomatic black and 50 white athletes aged 14-35-years-old with TWI and a normal echocardiogram who were referred to a UK tertiary center for cardiomyopathy and sports cardiology...
May 15, 2018: Circulation
https://www.readbyqxmd.com/read/29726891/understanding-the-role-of-the-perivascular-space-in-cerebral-small-vessel-disease
#2
Rosalind Brown, Helene Benveniste, Sandra E Black, Serge Charpak, Martin Dichgans, Anne Joutel, Maiken Nedergaard, Kenneth J Smith, Berislav V Zlokovic, Joanna M Wardlaw
Small vessel diseases are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood.Magnetic resonance imaging (MRI) has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29696529/utility-of-the-variable-flip-angle-3d-fast-spin-echo-isofse-sequence-on-3t-mr-for-diagnosing-vertebrobasilar-artery-dissection
#3
Masaki Ogawa, Shingo Omata, Hirohito Kan, Nobuyuki Arai, Marehiko Asai, Misugi Urano, Yuta Shibamoto
We aimed to investigate the utility of the isoFSE sequence, one of the variable flip angle 3D fast-spin echo sequences, on 3T-MR for displaying vessel walls and diagnosing vertebrobasilar artery dissection (VAD). We retrospectively evaluated 12 initial and 28 follow-up images from 12 patients diagnosed with either intracranial VAD or carotid artery dissection. The image quality for displaying the vessel wall was scored using a five-point scale (1 poor, 5 excellent) on initial T1-weighted isoFSE images for each region of the arteries...
April 25, 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29691080/implant-failure-after-motec-wrist-joint-prosthesis-due-to-failure-of-ball-and-socket-type-articulation-two-patients-with-adverse-reaction-to-metal-debris-and-polyether-ether-ketone
#4
Teemu Karjalainen, Konsta Pamilo, Aleksi Reito
We describe 2 cases of articulation-related failures resulting in revision surgery after a Motec total wrist arthroplasty: one with an adverse reaction to metal debris and the other with an adverse reaction to polyether ether ketone. In the first patient, blood cobalt and chrome levels were elevated and magnetic resonance imaging showed clear signs of a pseudotumor. The other patient had an extensive release of polyether ether ketone particles into the surrounding synovia due to adverse wear conditions in the cup, leading to the formation of a fluid-filled cyst sac with a black lining and diffuse lymphocyte-dominated inflammation in the synovia...
April 21, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29686791/lung-consolidation-as-a-rare-presentation-of-lymphoplasmacytic-lymphoma-with-extramedullary-waldenstr%C3%A3-m-s-macroglobulinemia
#5
Omar Abdulfattah, Ebad Ur Rahman, Bikash Bhattarai, Sumit Dahal, Zainab Alnafoosi, David Trauber, Danilo Enriquez, Frances Schmidt
Objectives : Lymphoplasmacytic lymphoma (LPL) is a mature B cell lymphoma that usually involves the bone marrow, spleen and lymph nodes. Extramedullary involvement, including the lung, is rarely reported. Case description : A 73-year-old female initially presented to our hospital complaining of productive cough of white-colour sputum for three weeks duration. She reported unintentional weight loss of ten pounds over the last five months. There was no history of haemoptysis, fever, night sweats, chills, recent infections or hospitalization...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29685534/three-dimensional-black-blood-contrast-enhanced-magnetic-resonance-imaging-in-patients-with-acute-ischemic-stroke-and-negative-susceptibility-vessel-sign
#6
Sung Hyun Baik, Hyo Sung Kwak, Seung Bae Hwang, Gyung Ho Chung
PURPOSE: The purpose of this study was to evaluate the enhancement patterns of three-dimensional (3D) black blood (BB) contrast enhanced magnetic resonance (MR) imaging in acute stroke patients with negative susceptibility vessel sign (SVS). MATERIALS AND METHODS: From January 2014 to August 2016 we retrospectively reviewed MR imaging and MR angiography findings of patients who presented with acute stroke symptoms of less than 24 h duration. For the 394 patients enrolled, we assessed the frequency of patients who exhibited negative SVS on susceptibility weighted MR imaging (SWI) and positive enhancement in 3D BB contrast enhanced MR imaging...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29619161/aneurysm-treatment-response-prediction-in-follow-up-black-blood-magnetic-resonance-imaging-a-case-series-study
#7
Athanasios K Petridis, Marian Suresh, Jan F Cornelius, Angelo Tortora, Hans Jakob Steiger, Bernd Turowski, Rebecca May
Black blood magnetic resonance imaging (MRI)is a promising imaging tool in predicting aneurysm rupture. Could it be also valuable in evaluating the treatment effect of endovascular and conservative treated aneurysms? Two patients were treated with stent and coil and one with Aspirine (ASS). Correlation of treatment response and contrast enhancement of the aneurysm wall is examined. In the first case stenting failed to treat the aneurysm and contrast enhancement in the wall did never subside during follow up black blood MRI...
January 8, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29571763/plaque-characteristics-of-patients-with-symptomatic-mild-carotid-artery-stenosis
#8
Hiroki Takai, Juniti Uemura, Yoshiki Yagita, Yukari Ogawa, Keita Kinoshita, Satoshi Hirai, Manabu Ishihara, Keijirou Hara, Hiroyuki Toi, Shunji Matsubara, Hirotake Nishimura, Masaaki Uno
BACKGROUND: Carotid revascularization may be considered for severe stenosis, but its use for symptomatic mild stenosis (<50%) with vulnerable plaque or ulcer remains uncertain. The characteristics of patients with symptomatic mild stenosis who underwent revascularization are reviewed. METHODS: The subjects of this study were 18 patients with symptomatic mild stenosis (<50%) on angiography from among 175 patients who underwent revascularization in our department...
March 20, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29567577/development-of-atherosclerotic-moyamoya-syndrome-with-genetic-variant-of-rnf213-p-r4810k-and-p-t1727m-a-case-report
#9
Ying Liu, Xueying Wu, Zhaoyang Fan, Jingdan Cheng, Lele Zhong, Yongzhong Lin, Xiaofeng Qu
OBJECTIVE: We report a rare case of atherosclerotic-moyamoya syndrome (A-MMS) in an adult female with genetic variant of both ring finger 213 (RNF213) p.R4810K and p.T1727M. CASE REPORT: A 46-year-old previously healthy, right-handed woman displayed transient slurred speech, which started to worsen four years ago. Initial magnetic resonance angiography (MRA) revealed stenosis in left middle cerebral artery (MCA), bilateral anterior cerebral artery (ACA), and left posterior cerebral artery (PCA)...
February 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29562921/gray-blood-late-gadolinium-enhancement-cardiovascular-magnetic-resonance-for-improved-detection-of-myocardial-scar
#10
Ahmed S Fahmy, Ulf Neisius, Connie W Tsao, Sophie Berg, Elizabeth Goddu, Patrick Pierce, Tamer A Basha, Long Ngo, Warren J Manning, Reza Nezafat
BACKGROUND: Low scar-to-blood contrast in late gadolinium enhanced (LGE) MRI limits the visualization of scars adjacent to the blood pool. Nulling the blood signal improves scar detection but results in lack of contrast between myocardium and blood, which makes clinical evaluation of LGE images more difficult. METHODS: GB-LGE contrast is achieved through partial suppression of the blood signal using T2 magnetization preparation between the inversion pulse and acquisition...
March 22, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29556767/three-dimensional-black-blood-contrast-enhanced-mri-improves-detection-of-intraluminal-thrombi-in-patients-with-acute-ischaemic-stroke
#11
Won Jang, Hyo Sung Kwak, Gyung Ho Chung, Seung Bae Hwang
OBJECTIVES: This study evaluated the utility of three-dimensional (3D), black-blood (BB), contrast-enhanced, magnetic resonance imaging (MRI) for the detection of intraluminal thrombi in acute stroke patients. METHODS: Forty-seven patients with acute stroke involving the anterior circulation underwent MRI examination within 6 h of clinical onset. Cerebral angiography was used as the reference standard. In a blinded manner, two neuroradiologists interpreted the following three data sets: (1) diffusion-weighted imaging (DWI) + 3D BB contrast-enhanced MRI; (2) DWI + susceptibility weighted imaging (SWI); (3) DWI + 3D BB contrast-enhanced MRI + SWI...
March 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29515084/a-comparison-of-black-blood-t-2-mapping-sequences-for-carotid-vessel-wall-imaging-at-3t-an-assessment-of-accuracy-and-repeatability
#12
Jianmin Yuan, Andrew J Patterson, Pascal P R Ruetten, Scott A Reid, Jonathan H Gillard, Martin J Graves
PURPOSE: This study is to compare the accuracy of four different black-blood T2 mapping sequences in carotid vessel wall. METHODS: Four different black-blood T2 mapping sequences were developed and tested through phantom experiments and 17 healthy volunteers. The four sequences were: 1) double inversion-recovery (DIR) prepared 2D multi-echo spin-echo (MESE); 2) DIR-prepared 2D multi-echo fast spin-echo (MEFSE); 3) improved motion-sensitized driven-equilibrium (iMSDE) prepared 3D FSE and 4) iMSDE prepared 3D fast spoiled gradient echo (FSPGR)...
March 8, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29508407/moderate-preterm-birth-affects-right-ventricular-structure-and-function-and-pulmonary-artery-blood-flow-in-adult-sheep
#13
Marshall M Mrocki, Vivian B Nguyen, Paul Lombardo, Megan R Sutherland, Jonathan G Bensley, Ilias Nitsos, Beth J Allison, Richard Harding, Robert De Matteo, Michal Schneider, Graeme R Polglase, M Jane Black
KEY POINTS: Preterm birth occurs when the heart muscle is immature and ill-prepared for the changes in heart and lung function at birth. MRI imaging studies show differences in the growth and function of the heart of young adults born preterm, with the effects more pronounced in the right ventricle. The findings of this study, conducted in sheep, showed that following moderate preterm birth the right ventricular wall was thinner in adulthood, with a reduction in the number and size of the heart muscle cells; in addition, there was impaired blood flow in the main artery leading from the right ventricle to the lungs...
March 6, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29505410/investigation-on-the-effect-of-spatial-compounding-on-photoacoustic-images-of-carotid-plaques-in-the-in-vivo-available-rotational-range
#14
M Umit Arabul, H Maarten Heres, Marcel C M Rutten, Marc R H M van Sambeek, Frans N van de Vosse, Richard G P Lopata
Photoacoustic imaging (PAI) is a promising imaging modality due to its high optical specificity. However, the low signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of in vivo PA images are major challenges that prevent PAI from finding its place in clinics. This paper investigates the merit of spatial compounding of PA images in arterial phantoms and the achievable improvements of SNR, when in vivo conditions are mimicked. The analysis of the compounding technique was performed on a polyvinyl alcohol vessel phantom with black threads embedded in its wall...
March 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29402851/intracranial-arterial-calcification-in-black-africans-with-acute-ischaemic-stroke
#15
Richard B Olatunji, Ademola J Adekanmi, Ayotunde O Ogunseyinde
BACKGROUND: Intracranial arterial calcification (IAC), a recognized marker of atherosclerosis on cranial computed tomography (CT), is an independent risk factor for ischaemic stroke. This study aimed to determine the prevalence, distribution, severity, and associations of IAC in adults with acute ischaemic stroke (AIS) at the University College Hospital, Ibadan, Nigeria. METHODS: Cranial CT images of 130 consecutive adults who presented with AIS were acquired on a 64-slice multi-detector Toshiba Aquilion scanner and evaluated for IAC in bone window on Vitrea® software using a semi-quantitative scoring method for extent, thickness, and length of calcifications in the large intracranial arteries...
January 15, 2018: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/29370208/coronary-magnetic-resonance-imaging-after-routine-implantation-of-bioresorbable-vascular-scaffolds-allows-non-invasive-evaluation-of-vascular-patency
#16
Constantin von Zur Mühlen, Simon Reiss, Axel J Krafft, Lisa Besch, Marius Menza, Manfred Zehender, Timo Heidt, Alexander Maier, Thomas Pfannebecker, Andreas Zirlik, Jochen Reinöhl, Peter Stachon, Ingo Hilgendorf, Dennis Wolf, Philipp Diehl, Tobias Wengenmayer, Ingo Ahrens, Christoph Bode, Michael Bock
BACKGROUND: Evaluation of recurrent angina after percutaneous coronary interventions is challenging. Since bioresorbable vascular scaffolds (BVS) cause no artefacts in magnetic resonance imaging (MRI) due to their polylactate-based backbone, evaluation of vascular patency by MRI might allow for non-invasive assessment and triage of patients with suspected BVS failure. METHODS: Patients with polylactate-based ABSORB-BVS in proximal coronary segments were examined with 3 Tesla MRI directly (baseline) and one year after implantation...
2018: PloS One
https://www.readbyqxmd.com/read/29353836/-optimal-conditions-for-3d-non-contrast-t-1-weighted-magnetic-resonance-imaging-segmented-turbo-fast-low-angle-shot-for-tissue-characterization-of-coronary-plaques
#17
Satoru Sato, Nobumasa Miyake
In three-dimensional (3D) T1 -weighted magnetic resonance imaging used for tissue characterization of coronary plaques, the contrast for electrocardiographic synchronization may vary according to the R-R interval (RR). The coronary artery plaque image shows suppression of the fluid compartment signal for the coronary artery luminal blood as well as the fat signal in the region of interest; in addition, it is necessary to ensure that the value of the plaque-to-muscle signal intensity ratio (PMR) does not change according to the difference in RR...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29307167/clinical-value-of-18f-fdg-pet-ct-and-3d-black-blood-3t-mri-for-the-diagnosis-of-large-vessel-vasculitis-and-single-organ-vasculitis-of-the-aorta
#18
Vera Wenter, Nora N Sommer, Hendrik Kooijman, Stefan Maurus, Marcus Treitl, Michael Czihal, Claudia Dechant, Marcus Unterrainer, Nathalie L Albert, Karla M Treitl
BACKGROUND: We aimed to investigate the clinical value of a 3D-T1w turbo-spin-echo (TSE) sequence and [18F]fluorodeoxyglucose positron emission tomography / computed tomography ([18F]FDG- PET/CT) for the diagnosis of active large vessel vasculitis (LVV) and single-organ vasculitis (SOV) of the aorta. METHODS: 24 patients with suspected vasculitis who underwent MRI and PET/CT were retrospectively evaluated. MRI was analyzed for concentric contrast enhancement and wall thickening, and flow artifact intensity (4-point-scales)...
January 2, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29284494/ferumoxytol-enhanced-black-blood-cardiovascular-magnetic-resonance-imaging
#19
Kim-Lien Nguyen, Eun-Ah Park, Takegawa Yoshida, Peng Hu, J Paul Finn
BACKGROUND: Bright-blood and black-blood cardiovascular magnetic resonance (CMR) techniques are frequently employed together during a clinical exam because of their complementary features. While valuable, existing black-blood CMR approaches are flow dependent and prone to failure. We aim to assess the effectiveness and reliability of ferumoxytol enhanced (FE) Half-Fourier Single-shot Turbo Spin-echo (HASTE) imaging without magnetization preparation pulses to yield uniform intra-luminal blood signal suppression by comparing FE-HASTE with pre-ferumoxytol HASTE imaging...
December 28, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29259930/intravascular-large-b-cell-lymphoma-with-multi-organ-failure-presenting-as-a-pancreatic-mass-a-case-with-atypical-presentation-and-definite-diagnosis-postmortem
#20
Faisal Mahmudul Huq Ronny, Margaret Ann Black, Arnaldo A Arbini
Intravascular large B-cell lymphoma (IVLBCL) is a very rare extra nodal lymphoma that tends to proliferate within small blood vessels, particularly capillaries and postcapillary venules while sparing the organ parenchyma. The cause of its affinity for the vascular bed remains unknown. Because of its rarity and unremarkable clinical presentation, a timely diagnosis of IVLBCL is very challenging. Here, we describe a case of IVLBCL presenting as pancreatic mass that was ultimately diagnosed at autopsy. A 71-year-old Caucasian female presented with a 3-month history of fatigue, abdominal pain, and weight loss...
October 2017: Autopsy & Case Reports
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