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Muscle regeneration

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https://www.readbyqxmd.com/read/29053994/dietary-resveratrol-confers-apoptotic-resistance-to-oxidative-stress-in-myoblasts
#1
Satoshi Haramizu, Shinichi Asano, David C Butler, David A Stanton, Ameena Hajira, Junaith S Mohamed, Stephen E Alway
High levels of reactive oxygen species (ROS) contribute to muscle cell death in aging and disuse. We have previously found that resveratrol can reduce oxidative stress in response to aging and hindlimb unloading in rodents in vivo, but it was not known if resveratrol would protect muscle stem cells during repair or regeneration when oxidative stress is high. To test the protective role of resveratrol on muscle stem cells directly, we treated the C2C12 mouse myoblast cell line with moderate (100 μM) or very high (1 mM) levels of H2O2 in the presence or absence of resveratrol...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053943/inflammation-status-of-healthy-young-men-initial-and-specific-responses-to-resistance-training
#2
Johanna K Ihalainen, Heikki Peltonen, Göran Paulsen, Juha P Ahtiainen, Ritva S Taipale, Mari Hämäläinen, Eeva Moilanen, Antti A Mero
PURPOSE: Our primary aim was to study the effects of a 4 wk preparatory resistance training (RT) period followed by 12 wks of two specific RT protocols (either hypertrophic-strength, HS, or strength-hypertrophy-power, SHP, training) on inflammation markers and the possible relationship of the changes in abdominal fat and lean mass to the changes in inflammation status. METHODS: A total of 82 healthy men were included in the study. Maximal concentric leg press strength (1RM), total body lean mass, total body and abdominal fat mass, circulating high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), monocyte chemoattractant protein 1 (MCP-1), and selected adipocytokines (resistin, adiponectin and leptin) concentrations were measured before (PRE) and after 4 (wk4) and 16 weeks (wk16) of RT...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29053841/meat-quality-traits-and-proteome-profile-of-woody-broiler-breast-pectoralis-major-meat
#3
K Cai, W Shao, X Chen, Y L Campbell, M N Nair, S P Suman, C M Beach, M C Guyton, M W Schilling
Woody breast meat has recently become prevalent in the broiler industry in both the United States and European Union. Recent publications have described the meat quality characteristics of woody breast meat as having hardened areas and pale ridge-like bulges at both the caudal and cranial regions of the breast. The present study investigated the meat quality (pH, color, cooking loss, and shear force) and protein quality characteristics (protein and salt-soluble protein content) in woody breast meat as compared to normal breast meat...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053076/protective-effect-of-biodegradable-nerve-conduit-against-peripheral-nerve-adhesion-after-neurolysis
#4
Kosuke Shintani, Takuya Uemura, Kiyohito Takamatsu, Takuya Yokoi, Ema Onode, Mitsuhiro Okada, Hiroaki Nakamura
OBJECTIVE Peripheral nerve adhesion caused by extraneural and intraneural scar formation after neurolysis leads to nerve dysfunction. The authors previously developed a novel very flexible biodegradable nerve conduit composed of poly(L-lactide) and poly(ε-caprolactone) for use in peripheral nerve regeneration. In the present study, they investigated the effect of protective nerve wrapping on preventing adhesion in a rat sciatic nerve adhesion model. METHODS Rat sciatic nerves were randomly assigned to one of the following four groups: a no-adhesion group, which involved neurolysis alone without an adhesion procedure; an adhesion group, in which the adhesion procedure was performed after neurolysis, but no treatment was subsequently administered; a nerve wrap group, in which the adhesion procedure was performed after neurolysis and protective nerve wrapping was then performed with the nerve conduit; and a hyaluronic acid (HA) group, in which the adhesion procedure was performed after neurolysis and nerve wrapping was then performed with a 1% sodium HA viscous solution...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29051551/reducing-sarcolipin-expression-mitigates-duchenne-muscular-dystrophy-and-associated-cardiomyopathy-in-mice
#5
Antanina Voit, Vishwendra Patel, Ronald Pachon, Vikas Shah, Mohammad Bakhutma, Erik Kohlbrenner, Joseph J McArdle, Louis J Dell'Italia, Jerry R Mendell, Lai-Hua Xie, Roger J Hajjar, Dongsheng Duan, Diego Fraidenraich, Gopal J Babu
Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) patients and animal models. Here we show that reducing SLN levels ameliorates dystrophic pathology in the severe dystrophin/utrophin double mutant (mdx:utr (-/-)) mouse model of DMD. Germline inactivation of one allele of the SLN gene normalizes SLN expression, restores SERCA function, mitigates skeletal muscle and cardiac pathology, improves muscle regeneration, and extends the lifespan...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29051003/spontaneous-regeneration-of-nerve-fiber-and-irreversibility-of-corporal-smooth-muscle-fibrosis-after-cavernous-nerve-crush-injury-evidence-from-serial-transmission-electron-microscopy-and-intracavernous-pressure
#6
Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Han-Sun Chiang
OBJECTIVES: To determine the pathophysiological progresses following bilateral cavernous nerve crushing (BCNC) injury, as an index for a treatment point and establishment of adequate treatment strategies for neurogenic erectile dysfunction (ED). METHODS: Thirty-six rats were assigned to 1 of 6 groups, and BCNC or sham surgery was performed. Functional testing and ultrastructural analyses were performed immediately and at 7, 14, 21, and 28 d after the cavernous nerve (CN) injury (n = 6)...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29047406/loss-of-mkp-5-promotes-myofiber-survival-by-activating-stat3-bcl-2-signaling-during-regenerative-myogenesis
#7
Kisuk Min, Ahmed Lawan, Anton M Bennett
BACKGROUND: The mitogen-activated protein kinases (MAPKs) have been shown to be involved in regulating myofiber survival. In skeletal muscle, p38 MAPK and JNK are negatively regulated by MAPK phosphatase-5 (MKP-5). During muscle regeneration, MKP-5 is downregulated, thereby promoting p38 MAPK/JNK signaling, and subsequent repair of damaged muscle. Mice lacking MKP-5 expression exhibit enhanced regenerative myogenesis. However, the effect of MKP-5 on myofiber survival during regeneration is unclear...
October 18, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/29047363/thymosin-%C3%AE-4-alleviates-renal-fibrosis-and-tubular-cell-apoptosis-through-tgf-%C3%AE-pathway-inhibition-in-uuo-rat-models
#8
Jing Yuan, Yan Shen, Xia Yang, Ying Xie, Xin Lin, Wen Zeng, Yingting Zhao, Maolu Tian, Yan Zha
BACKGROUND: Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine the effects of Tβ4 on the renal apoptosis and the expression of transforming growth factor (TGF-β), E-cadherin, and α-smooth muscle actin (α-SMA) in CRTIF rat models. METHODS: Male SD rats were randomized into four groups (sham group, unilateral ureteral obstruction (UUO) group, UUO + low-dose Tβ4 group, and UUO + high-dose Tβ4 group)...
October 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29046907/bladder-regeneration-in-a-canine-model-using-a-bladder-acellular-matrix-loaded-with-a-collagen-binding-bfgf
#9
Chunying Shi, Wei Chen, Bing Chen, Tao Shan, Weisheng Jia, Xianglin Hou, Longkun Li, Gang Ye, Jianwu Dai
Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds. In a previous study, we had used a collagen-binding basic fibroblast growth factor (CBD-bFGF) to bind bFGF to the collagen scaffold, which could promote bladder regeneration in rats. However, the limited graft size in rodent models cannot provide enough evidence to demonstrate the repair capabilities of this method for severely damaged bladders in humans or large animals. In this study, the CBD-bFGF was used to activate a bladder acellular matrix (BAM) scaffold, and the CBD-bFGF/BAM functional scaffold was assessed in a canine model with a large segment defect (half of the entire bladder was resected)...
October 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29044090/contralateral-eye-surgery-with-adjustable-suture-for-management-of-third-nerve-palsy-with-aberrant-regeneration
#10
Phuong Thi Thanh Nguyen, Shailja Tibrewal, Suma Ganesh
Aberrant regeneration of the third nerve following its palsy is commonly seen after trauma and compressive lesions. This phenomenon is thought to result due to misdirection of the regenerating axons. Surgical management is a great challenge in the third nerve palsy owing to multiple muscle involvement and is often accompanied by ptosis and poor Bell's phenomenon. We present a case of a 27-year-old male who developed isolated complete third nerve palsy of the left eye following head trauma. Features of aberrant regeneration were seen after 6 months, namely, inverse Duane's sign and Pseudo-Von Graefe's sign...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29041955/pluripotent-nontumorigenic-multilineage-differentiating-stress-enduring-cells-muse-cells-a-seven-year-retrospective
#11
REVIEW
Samantha C Fisch, María L Gimeno, Julia D Phan, Ariel A Simerman, Daniel A Dumesic, Marcelo J Perone, Gregorio D Chazenbalk
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers...
October 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29040534/macrophages-escape-klotho-gene-silencing-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy-and-promote-muscle-growth-and-increase-satellite-cell-numbers-through-a-klotho-mediated-pathway
#12
Michelle Wehling-Henricks, Steven S Welc, Guiseppina Samengo, Chiara Rinaldi, Catherine Lindsey, Ying Wang, Jeongyoon Lee, Makoto Kuro-O, James G Tidball
Duchenne muscular dystrophy (DMD) is a muscle wasting disease in which inflammation influences the severity of pathology. We found that the onset of muscle inflammation in the mdx mouse model of DMD coincides with large increases in expression of pro-inflammatory cytokines [tumor necrosis factor-α (TNFα); interferon gamma (IFNγ)] and dramatic reductions of the pro-myogenic protein Klotho in muscle cells and large increases of Klotho in pro-regenerative, CD206+ macrophages. Furthermore, TNFα and IFNγ treatments reduced Klotho in muscle cells and increased Klotho in macrophages...
October 12, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29040321/co-delivery-of-micronized-urinary-bladder-matrix-damps-regenerative-capacity-of-minced-muscle-grafts-in-the-treatment-of-volumetric-muscle-loss-injuries
#13
Stephen M Goldman, Benjamin T Corona
Minced muscle grafts (MG) promote de novo muscle fiber regeneration and neuromuscular strength recovery in small and large animal models of volumetric muscle loss. The most noteworthy limitation of this approach is its reliance on a finite supply of donor tissue. To address this shortcoming, this study sought to evaluate micronized acellular urinary bladder matrix (UBM) as a scaffolding to promote in vivo expansion of this MG therapy in a rat model. Rats received volumetric muscle loss injuries to the tibialis anterior muscle of their left hind limb which were either left untreated or repaired with minced muscle graft at dosages of 50% and 100% of the defect mass, urinary bladder matrix in isolation, or a with an expansion product consisting of a combination of the two putative therapies in which the minced graft is delivered at a dosage of 50% of the defect mass...
2017: PloS One
https://www.readbyqxmd.com/read/29039539/adenoviral%C3%A2-bone-morphogenetic-protein%C3%A2-7-and-or-doxazosin-therapies-promote-the-reversion-of-fibrosis-cirrhosis-in-a-cirrhotic-hamster-model
#14
Daniel Cervantes-Garcia, Adriana Guadalupe Cuellar-Juarez, Gissela Borrego-Soto, Augusto Rojas-Martinez, Liseth Rubi Aldaba-Muruato, Eva Salinas, Javier Ventura-Juarez, Martin Humberto Muñoz-Ortega
Liver fibrosis occurs in the presence of continuous insults, including toxic or biological agents. Novel treatments must focus on ceasing the progression of cellular damage, promoting the regeneration of the parenchyma and inhibition of the fibrotic process. The present study analyzed the effect of bone morphogenetic protein (BMP)‑7 gene therapy with or without co‑treatment with doxazosin in a model of liver cirrhosis in hamsters. The serum alanine aminotransferase, aspartate aminotransferase and albumin levels were analyzed spectrophotometrically...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038476/pro-angiogenic-effect-of-rantes-loaded-polysaccharide-based-microparticles-for-a-mouse-ischemia-therapy
#15
N Suffee, C Le Visage, H Hlawaty, R Aid-Launais, V Vanneaux, J Larghero, O Haddad, O Oudar, N Charnaux, A Sutton
Peripheral arterial disease results from the chronic obstruction of arteries leading to critical hindlimb ischemia. The aim was to develop a new therapeutic strategy of revascularization by using biodegradable and biocompatible polysaccharides-based microparticles (MP) to treat the mouse hindlimb ischemia. For this purpose, we deliver the pro-angiogenic chemokine Regulated upon Activation, Normal T-cell Expressed and Secreted (RANTES)/CCL5 in the mouse ischemic hindlimb, in solution or incorporated into polysaccharide-based microparticles...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038471/myoblasts-and-macrophages-are-required-for-therapeutic-morpholino-antisense-oligonucleotide-delivery-to-dystrophic-muscle
#16
James S Novak, Marshall W Hogarth, Jessica F Boehler, Marie Nearing, Maria C Vila, Raul Heredia, Alyson A Fiorillo, Aiping Zhang, Yetrib Hathout, Eric P Hoffman, Jyoti K Jaiswal, Kanneboyina Nagaraju, Sebahattin Cirak, Terence A Partridge
Exon skipping is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), employing morpholino antisense oligonucleotides (PMO-AO) to exclude disruptive exons from the mutant DMD transcript and elicit production of truncated dystrophin protein. Clinical trials for PMO show variable and sporadic dystrophin rescue. Here, we show that robust PMO uptake and efficient production of dystrophin following PMO administration coincide with areas of myofiber regeneration and inflammation. PMO localization is sustained in inflammatory foci where it enters macrophages, actively differentiating myoblasts and newly forming myotubes...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29038027/tumor-necrosis-factor-alpha-and-soluble-tnf-alpha-receptor-responses-in-young-vs-middle-aged-males-following-eccentric-exercise
#17
Eliott Arroyo, Adam J Wells, Joseph A Gordon, Alyssa N Varanoske, Yftach Gepner, Nicholas A Coker, David D Church, David H Fukuda, Jeffrey R Stout, Jay R Hoffman
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) has been shown to be implicated in both muscle regeneration and muscle wasting. However, it remains unclear whether TNF-α is responsible for the age-related losses in muscle size and function. Also, due to the high clearance rate of TNF-α from circulation, analyzing the circulating levels of soluble TNF-α receptors 1 and 2 (STNFR1 and STNFR2) may provide a better indication of inflammatory events. The aim of this study was to examine changes in circulating concentrations of TNF-α, STNFR1, and STNFR2 following acute eccentric exercise in young (YA) and middle-aged (MA) men...
October 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29037777/multipotency-of-skeletal-muscle-stem-cells-on-their-native-substrate-and-the-expression-of-connexin-43-during-adoption-of-adipogenic-and-osteogenic-fate
#18
Mohamed I Elashry, Manuela Heimann, Sabine Wenisch, Ketan Patel, Stefan Arnhold
Muscle regeneration is performed by resident muscle stem cells called satellite cells (SC). However they are multipotent, being able to adopt adipogenic and osteogenic fate under the correct stimuli. Since SC behavior can be regulated by the extra-cellular matrix, we examined the robustness of the myogenic programme of SC on their native substrate-the surface of a myofiber. We show that the native substrate supports myogenic differentiation judged by the expression of members of the Myogenic Determination Factor (MRF) family...
October 13, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29030819/single-edl-myofiber-isolation-for-analyses-of-quiescent-and-activated-muscle-stem-cells
#19
Caroline E Brun, Yu Xin Wang, Michael A Rudnicki
Adult satellite cells are quiescent, but are poised for activation in response to exercise, injury, or disease allowing adult muscle growth or repair. Once activated, satellite cells proliferate extensively to produce enough myogenic progenitors in order to regenerate the muscles. In order to self-renew, a subset of activated satellite cells can resist the myogenic differentiation and return to quiescence to replenish the satellite cell pool. These cellular processes that normally occur during skeletal muscle regeneration can be recapitulated ex vivo using isolated and cultured myofibers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29030619/unwavering-pathobiology-of-volumetric-muscle-loss-injury
#20
Sarah M Greising, Jessica C Rivera, Stephen M Goldman, Alain Watts, Carlos A Aguilar, Benjamin T Corona
Volumetric muscle loss (VML) resulting from extremity trauma presents chronic and persistent functional deficits which ultimately manifest disability. Acellular biological scaffolds, or decellularized extracellular matrices (ECMs), embody an ideal treatment platform due to their current clinical use for soft tissue repair, off-the-shelf availability, and zero autogenous donor tissue burden. ECMs have been reported to promote functional skeletal muscle tissue remodeling in small and large animal models of VML injury, and this conclusion was reached in a recent clinical trial that enrolled 13 patients...
October 13, 2017: Scientific Reports
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