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https://www.readbyqxmd.com/read/28918232/childhood-maltreatment-and-adolescent-sexual-risk-behaviors-unique-cumulative-and-interactive-effects
#1
Marie-Eve Thibodeau, Francine Lavoie, Martine Hébert, Martin Blais
Child maltreatment has been associated with sexual risk behaviors. Previous investigators have typically studied only one form of maltreatment, preventing them from exploring interrelations between forms of maltreatment and their impact on sexual risk behaviors. Thus, this study aims to examine the unique, cumulative, and interactive effects of four maltreatment forms (sexual abuse, physical abuse, neglect, and witnessing interparental violence) on sexual risk behaviors. The sample comprised 1940 sexually active adolescents (Mage=15...
September 14, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28918107/depression-evening-salivary-cortisol-and-inflammation-in-chronic-fatigue-syndrome-a-psychoneuroendocrinological-structural-regression-model
#2
Sara F Milrad, Daniel L Hall, Devika R Jutagir, Emily G Lattie, Sara J Czaja, Dolores M Perdomo, Mary Ann Fletcher, Nancy Klimas, Michael H Antoni
INTRODUCTION: Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and depression. Since depression is known to be associated with HPA axis dysfunction and greater inflammation, a psychoneuroendocrinological (PNE) model of inflammation was examined in persons diagnosed with CFS in order to uncover underlying biopsychosocial mechanisms in this poorly understood chronic illness...
September 13, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28917843/rapgef2-a-guanine-nucleotide-exchange-factor-for-rap1-small-gtpases-plays-a-crucial-role-in-adherence-junction-aj-formation-in-radial-glial-cells-through-erk-mediated-upregulation-of-the-aj-constituent-protein-expression
#3
Maged Ibrahim Farag, Yoko Yoshikawa, Kazuhiro Maeta, Tohru Kataoka
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap1, characterized by possession of the Ras/Rap-associating domains and implicated in the etiology of schizophrenia. We previously found that dorsal telencephalon-specific Rapgef2 conditional knockout mice exhibits severe defects in formation of apical surface adherence junctions (AJs) and localization of radial glial cells (RGCs). In this study, we analyze the underlying molecular mechanism by using primary cultures of RGCs established from the developing cerebral cortex...
September 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28917394/childhood-maltreatment-severity-and-alcohol-use-in-adult-psychiatric-inpatients-the-mediating-role-of-emotion-regulation-difficulties
#4
Christina D Dutcher, Anka A Vujanovic, Daniel J Paulus, Brooke A Bartlett
OBJECTIVE: Emotion regulation difficulties are a potentially key mechanism underlying the association between childhood maltreatment and alcohol use in adulthood. The current study examined the mediating role of emotion regulation difficulties in the association between childhood maltreatment severity (i.e., Childhood Trauma Questionnaire total score) and past-month alcohol use severity, including alcohol consumption frequency and alcohol-related problems (i.e., number of days of alcohol problems, ratings of "bother" caused by alcohol problems, ratings of treatment importance for alcohol problems)...
September 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28917067/dengue-fever-clinical-features-of-567-consecutive-patients-admitted-to-a-tertiary-care-center-in-saudi-arabia
#5
Samar Badreddine, Fahmi Al-Dhaheri, Ammar Al-Dabbagh, Abdulrahman Al-Amoudi, Maged Al-Ammari, Nader Elatassi, Haytham Abbas, Rami Magliah, Abdulbasit Malibari, Hani Almoallim
To delineate the clinical features and outcomes of dengue infection and to guide clinician of early diagnosis and identification of risks factors for dengue hemorrhagic fever. Methods: This study is a retrospective cross-sectional. Clinical records of 567 patients with a confirmed diagnosis of dengue infection, admitted to a single hospital in Jeddah, Saudi Arabia, between January 2010 and  June 2014 were reviewed.  Results: Dengue infection was most common in adult males. Sixty-eight percent of infections were in Saudi nationals...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28916435/a-novel-electrochemical-immunosensor-based-on-ito-modified-by-carboxyl-ended-silane-agent-for-ultrasensitive-detection-of-mage-1-in-human-serum
#6
Aslı Gündoğdu, Elif Burcu Aydın, Mustafa Kemal Sezgintürk
A new, low-cost electrochemical immunosensor was developed for rapid detection of Melanoma-associated antigen 1 (MAGE-1), a cancer biomarker. The fabrication procedure of immunosensor was based on the covalent immobilization of anti-MAGE-1, biorecognition molecule, on ITO electrode by carboxyethylsilanetriol (CTES) monolayer. The biosensing MAGE-1 antigen was monitored by using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) technique. Apart from these techniques, single frequency impedance (SFI) was used for investigation of antibody-antigen interactions...
September 12, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28916277/circulating-tumor-cell-as-a-biomarker-for-evaluating-allogenic-nk-cell-immunotherapy-on-stage-%C3%A2-non-small-cell-lung-cancer
#7
Mao Lin, Shu-Zhen Liang, Jian Shi, Li-Zhi Niu, Ji-Bing Chen, Ming-Jie Zhang, Ke-Cheng Xu
In this study, we determined the number of peripheral blood circulating tumor cells (CTCs) pre- and post-NK in patients with stage Ⅳ non- small cell lung cancer (NSCLC) as a reference for understanding the relevance of any changes to the efficacy of NK cells therapy. The patients were given one to three courses of immunotherapy.CTC numbers and CTC-related gene expression were measured in the peripheral blood of 31 patients with stage Ⅳ NSCLC at 1day before and 7 and 30 d after NK cells therapy using magnetic activated cell sorting (MACS) and fluorescence activated cell sorting (FACS) combined with real-time quantitative PCR (RT-qPCR)...
September 12, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28913833/symptom-trajectories-throughout-two-family-therapy-treatments-for-adolescent-anorexia-nervosa
#8
Stuart B Murray, Eva Pila, Daniel Le Grange, Susan M Sawyer, Elizabeth K Hughes
OBJECTIVE: This study aimed to examine the trajectory of symptom remission and affective functioning throughout the course of two family-based treatments for adolescent anorexia nervosa (AN): conjoint family-based treatment (FBT) and parent-focused treatment (PFT). METHOD: Participants were 107 adolescents (Mage  = 15.5 years, SD = 1.5) with a primary diagnosis of AN who participated in a randomized clinical trial comparing FBT (N = 55) and PFT (N = 51)...
September 15, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28910673/a-randomized-controlled-evaluation-of-a-secondary-school-mindfulness-program-for-early-adolescents-do-we-have-the-recipe-right-yet
#9
Catherine Johnson, Christine Burke, Sally Brinkman, Tracey Wade
OBJECTIVE: Mindfulness is being promoted in schools as a prevention program despite a current small evidence base. The aim of this research was to conduct a rigorous evaluation of the .b ("Dot be") mindfulness curriculum, with or without parental involvement, compared to a control condition. METHOD: In a randomized controlled design, students (Mage 13.44, SD 0.33; 45.4% female) across a broad range of socioeconomic indicators received the nine lesson curriculum delivered by an external facilitator with (N = 191) or without (N = 186) parental involvement, or were allocated to a usual curriculum control group (N = 178)...
September 6, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28910565/an-in-vivo-study-adjuvant-activity-of-poly-n-vinyl-2-pyrrolidone-co-acrylic-acid-on-immune-responses-against-melanoma-synthetic-peptide
#10
Kadriye Kızılbey, Banu Mansuroğlu, Serap Derman, Zeynep Mustafaeva Akdeste
INTRODUCTION: Peptides have been studied as an important class of components in medicine to control many major diseases with vaccination. Polymers as adjuvants are capable of enhancing the vaccine potential against various diseases by improving the delivery of antigens, and they reduce the booster doses of vaccines. In brief, polymers are promising candidates for peptide-based vaccine delivery platforms. The purpose of the present study was to create a possible alternative approach in the treatment of malignant melanoma and/or to prevent metastasis of melanoma...
September 14, 2017: Bioengineered
https://www.readbyqxmd.com/read/28910192/subjective-life-expectancy-among-college-students
#11
Alyssa E Rodemann, Danielle Arigo
Establishing healthy habits in college is important for long-term health. Despite existing health promotion efforts, many college students fail to meet recommendations for behaviors such as healthy eating and exercise, which may be due to low perceived risk for health problems. The goals of this study were to examine: (1) the accuracy of life expectancy predictions, (2) potential individual differences in accuracy (i.e., gender and conscientiousness), and (3) potential change in accuracy after inducing awareness of current health behaviors...
September 14, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28910178/interpersonal-and-intrapersonal-differences-among-adolescent-nonsmokers-ex-smokers-and-smokers
#12
Salvatore Ioverno, Roberto Baiocco, Fiorenzo Laghi, Valeria Verrastro, Carmen Odorifero, Marcella Dittrich
BACKGROUND: A large body of research has traced tobacco dependence among adolescents to a series of intrapersonal and interpersonal factors. However, there are remaining questions regarding the differences on these factors related to tobacco use. OBJECTIVES: We sought to investigate intrapersonal and interpersonal differences among adolescent nonsmokers, ex-smokers, and smokers. METHODS: We used data from a 3-year project designed to investigate and address tobacco dependence among 1071 students (Mage = 15...
September 14, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28906321/variceal-hemorrhage-and-adverse-liver-outcomes-in-patients-with-cystic-fibrosis-cirrhosis
#13
Wen Ye, Michael R Narkewicz, Daniel H Leung, Wikrom Karnsakul, Karen F Murray, Estella M Alonso, John C Magee, Sarah Jane Schwarzenberg, Alexander Weymann, Jean P Molleston
OBJECTIVES: Cirrhosis occurs in 5-10% of CF (cystic fibrosis) patients, often accompanied by portal hypertension. We analyzed three adverse liver outcomes, variceal bleeding (VB), liver transplant (LT), and liver death (LD), and risk factors for these in CF Foundation Patient Registry (CFFPR) subjects with reported cirrhosis. METHODS: We determined 10-year incidence rates for VB, LT, LD, and all-cause mortality (ACM), and examined risk factors using competing risk models and Cox-proportional hazard regression...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28903682/differential-and-domain-specific-associations-among-right-wing-authoritarianism-social-dominance-orientation-and-adolescent-delinquency
#14
Benjamin Oosterhoff, Natalie J Shook, Russ Clay, Aaron Metzger
Using a dual-process model (DPM) framework, this research examined whether right-wing authoritarianism (RWA) and social dominance orientation (SDO) are differentially associated with adolescent delinquency. In Study 1 ( N = 847; Mage = 15.96) and Study 2 ( N = 340; Mage = 16.64), adolescents completed measures of RWA, SDO, and engagement in different forms of delinquency. In Study 2, adolescents also reported their beliefs about obeying different laws. Across both studies, adolescents who endorsed greater RWA engaged in lower levels of delinquency and those who endorsed greater SDO engaged in higher levels of delinquency...
September 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28902386/consequences-of-individual-differences-in-children-s-formal-understanding-of-mathematical-equivalence
#15
Nicole M McNeil, Caroline Byrd Hornburg, Brianna L Devlin, Cristina Carrazza, Mary O McKeever
Experts claim that individual differences in children's formal understanding of mathematical equivalence have consequences for mathematics achievement; however, evidence is lacking. A prospective, longitudinal study was conducted with a diverse sample of 112 children from a midsized city in the Midwestern United States (Mage [second grade] = 8:1). As hypothesized, understanding of mathematical equivalence in second grade predicted mathematics achievement in third grade, even after controlling for second-grade mathematics achievement, IQ, gender, and socioeconomic status...
September 13, 2017: Child Development
https://www.readbyqxmd.com/read/28901536/validation-of-the-pedsql-epilepsy-module-a-pediatric-epilepsy-specific-health-related-quality-of-life-measure
#16
Avani C Modi, Katherine F Junger, Constance A Mara, Tanja Kellermann, Lauren Barrett, Janelle Wagner, Grace A Mucci, Laurie Bailey, Dace Almane, Shanna M Guilfoyle, Lauryn Urso, Brooke Hater, Heather Hustzi, Gigi Smith, Bruce Herrmann, M Scott Perry, Mary Zupanc, James W Varni
OBJECTIVE: To validate a brief and reliable epilepsy-specific, health-related quality of life (HRQOL) measure in children with various seizure types, treatments, and demographic characteristics. METHODS: This national validation study was conducted across five epilepsy centers in the United States. Youth 5-18 years and caregivers of youth 2-18 years diagnosed with epilepsy completed the PedsQL Epilepsy Module and additional questionnaires to establish reliability and validity of the epilepsy-specific HRQOL instrument...
September 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28901514/multimodal-actions-of-the-phytochemical-sulforaphane-suppress-both-ar-and-ar-v7-in-22rv1-cells-advocating-a-potent-pharmaceutical-combination-against-castration-resistant-prostate-cancer
#17
Namrata Khurana, Hogyoung Kim, Partha K Chandra, Sudha Talwar, Pankaj Sharma, Asim B Abdel-Mageed, Suresh C Sikka, Debasis Mondal
Prostate cancer (PCa) cells expressing full-length androgen receptor (AR-FL) are susceptible to androgen deprivation therapy (ADT). However, outgrowth of castration-resistant prostate cancer (CRPC) can occur due to the expression of constitutively active (ligand-independent) AR splice variants, particularly AR-V7. We previously demonstrated that sulforaphane (SFN), an isothiocyanate phytochemical, can decrease AR-FL levels in the PCa cell lines, LNCaP and C4-2B. Here, we examined the efficacy of SFN in targeting both AR-FL and AR-V7 in the CRPC cell line, CWR22Rv1 (22Rv1)...
August 30, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28899159/book-review-a-murder-over-a-girl-justice-gender-junior-high-a-murder-over-a-girl-justice-gender-junior-high-by-corbett-ken-new-york-henry-holt-2016-xiv-273-pp-27-00-hardcover
#18
https://www.readbyqxmd.com/read/28898988/comparison-of-oncotype-dx-with-modified-magee-equation-recurrence-scores-in-low-grade-invasive-carcinoma-of-breast
#19
Yanjun Hou, Debra L Zynger, Xiaoxian Li, Zaibo Li
Objectives: Several specific histologic types of invasive carcinoma of breast, including invasive tubular carcinoma (ITC), invasive mucinous carcinoma (IMC), and classical invasive lobular carcinoma (CILC), are considered low-grade carcinomas with favorable outcomes. We aimed to investigate the utility of Oncotype DX test in these tumors by comparing its recurrence score (RS) with the modified Magee equation RS. Methods: Oncotype DX RSs were collected and modified Magee equation RSs were calculated in 163 low-grade invasive breast carcinomas, including 105 CILCs, 41 ITCs, and 17 IMCs...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28895384/securing-the-airway-in-patients-with-cervical-spine-injury-the-pursuit-of-the-ideal-airway-gadget
#20
Maged Y Argalious
No abstract text is available yet for this article.
September 11, 2017: Minerva Anestesiologica
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