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https://www.readbyqxmd.com/read/29778918/cognitive-mechanisms-of-sleep-outcomes-in-a-randomized-clinical-trial-of-internet-based-cognitive-behavioral-therapy-for-insomnia
#1
Philip I Chow, Karen S Ingersoll, Frances P Thorndike, Holly R Lord, Linda Gonder-Frederick, Charles M Morin, Lee M Ritterband
OBJECTIVE: The aim of this study was to investigate in a randomized clinical trial the role of sleep-related cognitive variables in the long-term efficacy of an online, fully automated cognitive behavioral therapy intervention for insomnia (CBT-I) (Sleep Healthy Using the Internet [SHUTi]). METHOD: Three hundred and three participants (Mage  = 43.3 years; SD = 11.6) were randomly assigned to SHUTi or an online patient education condition and assessed at baseline, postintervention (nine weeks after baseline), and six and 12 months after the intervention period...
December 20, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29778720/inflammatory-response-following-in-vitro-exposure-to-methylmercury-with-and-without-n-3-long-chain-polyunsaturated-fatty-acids-in-peripheral-blood-mononuclear-cells-from-systemic-lupus-erythematosus-patients-compared-to-healthy-controls
#2
William Crowe, Philip J Allsopp, Jennifer F Nyland, Pamela J Magee, J J Strain, Leanne C Doherty, Gene E Watson, Elisabeth Ball, Claire Riddell, David J Armstrong, Kayla Penta, Joshua J Todd, Toni Spence, Emeir M McSorley
Methylmercury (MeHg) is a proposed environmental stimulus in systemic lupus erythematosus (SLE). Humans are primarily exposed to MeHg through fish consumption. Fish are also important sources of n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). This in vitro study investigated the inflammatory response of isolated peripheral blood mononuclear cells (PBMCs), when exposed to either MeHg alone or with added n-3 LCPUFA, from SLE patients (N = 12) compared to healthy sex matched controls (N = 12)...
May 17, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29778232/nuclear-bap1-loss-is-common-in-intrahepatic-cholangiocarcinoma-and-a-subtype-of-hepatocellular-carcinoma-but-rare-in-pancreatic-ductal-adenocarcinoma
#3
Asmaa Mosbeh, Khalil Halfawy, Wael S Abdel-Mageed, Dina Sweed, Mohamed H Abdel Rahman
Deletion in the 3p21 region, the chromosomal location of BAP1, has been reported in a subset of hepatocellular carcinoma (HCC), biliary and pancreatic cancers. This suggests that BAP1 could play a role in the pathogenesis of these tumors. We assessed the frequency of BAP1 loss by immunohistochemistry in 103 hepatic, biliary and pancreatic cancers. We also assessed chromosomal alterations in the BAP1 region in the same tumors by genotyping. We identified high frequency 4/8 (50%) of BAP1 loss in intrahepatic cholangicarcinoma (ICC)...
August 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29777546/evaluating-links-among-shyness-peer-relations-and-internalizing-problems-in-chinese-young-adolescents
#4
Junsheng Liu, Julie C Bowker, Robert J Coplan, Panpan Yang, Dan Li, Xinyin Chen
This study evaluates a model linking shyness, aspects of peer relations, and internalizing problems among young adolescents in the People's Republic of China. Participants were 547 young adolescents from Shanghai, China (46% boys; Mage  = 10.35 years, SD = 0.77 years) who completed peer nominations of shyness, rejection, and victimization, and self-report measures of loneliness, depression, and friendship support. Analyses demonstrated that peer difficulties (rejection, victimization) mediated the associations between shyness and internalizing problems...
May 19, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29775874/emotion-regulation-as-a-predictor-of-the-endocrine-autonomic-affective-and-symptomatic-stress-response-and-recovery
#5
Katarina Krkovic, Annika Clamor, Tania M Lincoln
Stress is associated with the development of mental disorders such as depression and psychosis. The ability to regulate emotions is likely to influence how individuals respond to and recover from acute stress, and may thus be relevant to symptom development. To test this, we investigated whether self-reported emotion regulation predicts the endocrine, autonomic, affective, and symptomatic response to and recovery from a stressor. Social-evaluative stress was induced by the Trier Social Stress Test (TSST) in N = 67 healthy individuals (53...
April 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775813/hyaluronate-lactoferrin-layer-by-layer-coated-lipid-nanocarriers-for-targeted-co-delivery-of-rapamycin-and-berberine-to-lung-carcinoma
#6
Dalia M Kabary, Maged W Helmy, Kadria A Elkhodairy, Jia-You Fang, Ahmed O Elzoghby
The self-tumor targeting polymers, lactoferrin (LF) and hyaluronic acid (HA) were utilized to develop layer-by-layer (LbL) lipid nanoparticles (NPs) for dual delivery of berberine (BER) and rapamycin (RAP) to lung cancer. To control its release from the NPs, BER was hydrophobically ion paired with SLS prior to incorporation into NPs. Spherical HA/LF-LbL-RAP-BER/SLS-NPs 250.5 nm in diameter, with a surface charge of -18.5 mV were successfully elaborated. The NPs exhibited sequential release pattern with faster release of BER followed by controlled release of RAP which enables sensitization of lung tumor cells to the anti-cancer action of RAP...
May 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29775640/prestimulus-delta-and-theta-contributions-to-equiprobable-go-nogo-processing-in-healthy-ageing
#7
Frances M De Blasio, Robert J Barry
Ongoing EEG activity contributes to ERP outcomes of stimulus processing, and each of these measures is known to undergo (sometimes significant) age-related change. Variation in their relationship across the life-span may thus elucidate mechanisms of normal and pathological ageing. This study assessed the relationships between low-frequency EEG prestimulus brain states, the ERP, and behavioural outcomes in a simple equiprobable auditory Go/NoGo paradigm, comparing these for 20 young (Mage  = 20.4 years) and 20 healthy older (Mage  = 68...
May 15, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29774791/insomnia-and-eating-expectancies-among-college-students-the-role-of-emotion-dysregulation
#8
Brooke Y Kauffman, Jafar Bakhshaie, Hantin Lam, Candice Alfano, Michael J Zvolensky
There is limited understanding of the relation between insomnia and aspects of eating among college students though available data suggest salient clinical relationships. The present study explored a potential transdiagnostic mechanism in the relation between insomnia symptoms and eating expectancies. Participants were a racially/ethnically diverse sample of 1589 college students (80.4% females; Mage = 22.2 years, SD = 5.27) from an urban university. Primary analysis included three regression-based models of eating expectancies...
May 18, 2018: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/29771557/distress-tolerance-associations-with-trauma-and-substance-cue-reactivity-in-low-income-inner-city-adults-with-substance-use-disorders-and-posttraumatic-stress
#9
Anka A Vujanovic, Margaret C Wardle, Jafar Bakhshaie, Lia J Smith, Charles E Green, Scott D Lane, Joy M Schmitz
Cue reactivity has great potential to advance our understanding of posttraumatic stress disorder (PTSD), substance use disorder (SUD), and PTSD/SUD comorbidity. The present investigation examined distress tolerance (DT) with regard to trauma and substance cue reactivity. Participants included 58 low-income, inner-city adults (49.1% women; Mage = 45.73, SD = 10.00) with substance dependence and at least 4 symptoms of PTSD. A script-driven cue reactivity paradigm was utilized. Four DT measures were administered, including the Distress Tolerance Scale (DTS), Mirror-Tracing Persistence Task (MTPT), Breath-Holding Task (BH), and Paced Auditory Serial Addition Task (PASAT)...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29770541/effect-of-short-term-treatment-with-sitagliptin-or-glibenclamide-on-daily-glucose-fluctuation-in-drug-na%C3%A3-ve-japanese-patients-with-type-2-diabetes-mellitus
#10
Ryo Suzuki, Jun-Ichi Eiki, Takashi Moritoyo, Kenichi Furihata, Akira Wakana, Yukari Ohta, Shigeru Tokita, Takashi Kadowaki
AIMS: To compare the effect of a dipeptidyl peptidase-4 inhibitor (DPP4-i) and a sulfonylurea (SU) on daily glucose fluctuation in drug-naïve Japanese patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Fifty-three drug-naïve Japanese patients with T2DM (HbA1c of 7.0% to 9.0% and fasting plasma glucose of 6.1 mmol/L or higher) were randomly assigned to either sitagliptin 50 mg q.d. or glibenclamide 2.5 mg per day (given in divided doses) in a 1:1 ratio...
May 17, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29769115/lifestyle-choices-and-mental-health-a-longitudinal-survey-with-german-and-chinese-students
#11
Julia Velten, Angela Bieda, Saskia Scholten, André Wannemüller, Jürgen Margraf
BACKGROUND: A healthy lifestyle can be beneficial for one's mental health. Thus, identifying healthy lifestyle choices that promote psychological well-being and reduce mental problems is useful to prevent mental disorders. The aim of this longitudinal study was to evaluate the predictive values of a broad range of lifestyle choices for positive mental health (PMH) and mental health problems (MHP) in German and Chinese students. METHOD: Data were assessed at baseline and at 1-year follow-up...
May 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29767896/-high-grade-serous-ovarian-cancer-2018-advances-and-controversies
#12
Nuria Mederos, Anita Wolfer, Patrice Mathevet, Maged Zaher, Apostolos Sarivalasis
The primary treatment of ovarian cancer consists in a complete surgical debulking followed by adjuvant chemotherapy combining platinum with taxanes. Despite this treatment, patient survival has remained stable over the last 20 years. Recently, advances in the sequence, regimens, and route of administration of treatment have enhanced effectiveness and reduced toxicity. Targeted anti-angiogenic therapy and recently PARP inhibitors are now complementing standard treatment and have improved patient progression-free survival...
May 16, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29767781/adolescent-condom-use-and-connectivity-in-the-social-planful-brain
#13
Justin D Caouette, Karen A Hudson, Angela D Bryan, Sarah W Feldstein Ewing
Objective: To reduce rates of sexually transmitted infections (STIs) and unwanted pregnancy among adolescents, it is critical to investigate brain connectivity that may underlie adolescents' sexual health decision-making in the context of intercourse. This study explored relationships between adolescent condom use frequency and the brain's resting-state functional connectivity, to identify differential patterns of social-affective processing among sexually active youth. Methods: In this study, N = 143 sexually active adolescents (68...
May 14, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29767676/complete-streets-and-adult-bicyclist-fatalities-applying-g-computation-to-evaluate-an-intervention-that-affects-the-size-of-a-population-at-risk
#14
Stephen J Mooney, Caroline Magee, Kolena Dang, Julie C Leonard, Jingzhen Yang, Frederick P Rivara, Beth E Ebel, Ali Rowhani-Rahbar, D Alex Quistberg
"Complete Streets" policies require transportation engineers to make provisions for pedestrians, cyclists and transit users. These policies may make bicycling safer for individual cyclists while increasing overall bicycle fatalities if more individuals cycle due to improved infrastructure. We merged county-level records of Complete Streets policies with Fatality Analysis Reporting System counts of cyclist fatalities occurring between January 2000 and December 2015. Because comprehensive county cycling estimates were not available, we used bicycle commute estimates from the American Community Survey and US Census as a proxy for the cycling population, and limited analysis to 183 counties (accounting for over half the US population) for which cycle commute estimates were consistently non-zero...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29763778/mage-a-antigens-as-targets-for-cancer-immunotherapy
#15
REVIEW
Erik Schooten, Alessia Di Maggio, Paul M P van Bergen En Henegouwen, Marta M Kijanka
Targeted anti-cancer therapies aim at reducing side effects while retaining their anti-cancer efficacy. Immunotherapies e.g. monoclonal antibodies, adoptive T cell therapy and cancer vaccines are used to combat cancer, but the number of available cancer specific targets is limited and new approaches are needed to generate more effective and patient tailored treatments. Unique cancer intracellular epitopes can be presented on the cell surface by MHC class I molecules, which can function as epitopes for targeted therapies...
April 26, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29758380/predictors-of-positive-drinking-outcomes-among-youth-receiving-an-alcohol-brief-intervention-in-the-emergency-department
#16
Alan K Davis, Brooke J Arterberry, Erin E Bonar, Stephen T Chermack, Frederic C Blow, Rebecca M Cunningham, Maureen A Walton
BACKGROUND: Reducing underage drinking is a public health priority given increased risk for injury and other consequences. Emergency department (ED) visits offer a potential "teachable moment" to initiate interventions among youth engaged in risky drinking. Given mixed findings for alcohol brief interventions (BIs), this paper examined baseline markers of BI response in order to inform future interventions. METHOD: We conducted secondary analyses of data from a randomized controlled trial of an alcohol BI delivered to youth in an ED...
May 5, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29756798/affective-experience-across-the-adult-lifespan-an-accelerated-longitudinal-design
#17
Raquael J Joiner, Cindy S Bergeman, Lijuan Wang
Recent research investigating the course of affective development across the adult life span has incorporated both cross-sectional and longitudinal data in analyses to understand the aging-affect relationship. Most of these studies, however, have not provided an empirical test to determine whether the cross-sectional and longitudinal data can be combined to infer developmental processes. Utilizing an age heterogeneous sample followed over a 10-year span (N = 1,019, Mage = 54.14 ± 13.06), the present study used an accelerated longitudinal design to investigate whether cross-sectional age differences could be found in longitudinal aging trajectories of positive affect (PA), negative affect (NA), and their confluence (i...
May 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29756255/comparative-optimism-in-older-adults-future-health-expectations
#18
Karen Vanderzanden, Joelle C Ruthig
OBJECTIVES: Despite a common belief that health declines with age, many older adults remain optimistic about their future health. However, the longitudinal impact of personal and comparatively optimistic future health estimates (FHEs) is unclear. METHOD: Among 408 older adults (Mage  = 70.32 years), this study identified the prevalence, source, and two-year stability of comparatively optimistic FHEs; examined demographic, psychosocial, and health correlates of comparative FHEs; and assessed the role of comparative FHEs in predicting eight-year survival odds...
May 13, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29755666/impact-of-lenalidomide-maintenance-on-the-immune-environment-of-multiple-myeloma-patients-with-low-tumor-burden-after-autologous-stem-cell-transplantation
#19
Karel Fostier, Jo Caers, Nathalie Meuleman, Katrijn Broos, Jurgen Corthals, Kris Thielemans, Rik Schots, Brenda De Keersmaecker
Lenalidomide is a potent anti-myeloma drug with immunomodulatory properties. It is increasingly used in a low-dose maintenance setting to prolong remission duration after standard treatment. Data on the in vivo effects of lenalidomide are scarce and sometimes different from the well-described in vitro effects. We therefore evaluated the numerical, phenotypical and functional impact of lenalidomide maintenance on several immune cell types in a cohort of seventeen homogeneously treated myeloma patients achieving a low residual myeloma burden after a bortezomib based-induction followed by autologous stem cell transplantation...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29754497/the-compensatory-adhd-behaviors-scale-cabs-development-and-initial-validation
#20
Peter J Castagna, Scott Roye, Matthew Calamia
Several measures are available that assess inattention, hyperactivity/impulsivity, and executive functioning deficits. Treatments for adults with attention-deficit/hyperactivity disorder (ADHD) and skill-based academic interventions focus on improving compensatory strategies to ameliorate functional impairment; however, no measure exists that examines the compensatory behaviors adults utilize to compensate for the functional deficits associated with inattention and hyperactivity/impulsivity. The current study aimed to determine the psychometric properties of the Compensatory ADHD Behaviors Scale (CABS)...
May 1, 2018: Assessment
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