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https://www.readbyqxmd.com/read/29149541/diagnostic-accuracy-of-serum-mir-122-and-mir-199a-in-women-with-endometriosis
#1
Ahmed M Maged, Wesam S Deeb, Azza El Amir, Sherif S Zaki, Heba El Sawah, Maged Al Mohamady, Ahmed A Metwally, Maha A Katta
OBJECTIVE: To evaluate the value of serum microRNA-122 (miR-122) and miR-199a as reliable noninvasive biomarkers in the diagnosis of endometriosis. METHODS: During 2015-2016, at a teaching hospital in Egypt, a prospective cohort study was conducted on 45 women with pelvic endometriosis and 35 women who underwent laparoscopy for pelvic pain but were not diagnosed with endometriosis. Blood and peritoneal fluid (PF) samples were collected; interleukin-6 (IL-6) was detected by enzyme-linked immunosorbent assay and miR-122 and miR-199a expression was measured by quantitative real-time polymerase chain reaction...
November 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29145937/defending-victims-what-does-it-take-to-intervene-in-bullying-and-how-is-it-rewarded-by-peers
#2
Rozemarijn van der Ploeg, Tina Kretschmer, Christina Salmivalli, René Veenstra
Defending is considered important in reducing bullying and victimization in schools. Yet, the prevalence of defending is quite low and there is little insight into aspects that explain why students intervene in bullying situations. The current study used a longitudinal design to simultaneously examine the antecedents and status outcomes of defending behavior. It was expected that affective and social-cognitive factors explain involvement in defending. Moreover, it was proposed that defending would be rewarded with popularity among peers, but only for defenders who were not victimized themselves...
December 2017: Journal of School Psychology
https://www.readbyqxmd.com/read/29144853/sexual-experiences-in-transgender-people-the-role-of-desire-for-gender-confirming-interventions-psychological-well-being-and-body-satisfaction
#3
Sanne W C Nikkelen, Baudewijntje P C Kreukels
We examined the role of gender confirming treatment (i.e., hormonal treatment and genital surgery; GCT), psychological well-being, and body satisfaction in the sexual feelings and behaviors of transgender adults. A survey was conducted among a non-clinical sample of 325 male-to-female and 251 female-to-male Dutch adults (17-76yr, Mage = 41.87), divided into those with no GCT desire, those who desired (more) GCT, and those who completed GCT. Findings indicated that whereas GCT may positively affect sexual feelings, particularly in MtF's, body satisfaction may play an even bigger role...
November 16, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29143181/hla-dq2-and-dq8-haplotypes-frequency-and-diagnostic-utility-in-celiac-disease-patients-of-gaza-strip-palestine
#4
Basim M Ayesh, Eman Kh Zaqout, Maged M Yassin
PURPOSE: Celiac disease (CD) diagnosis can be established by serological and small bowel biopsy (SBB), while absence of HLA-DQ2 and -DQ8 haplotypes excludes the disease. The present study aims at evaluating the diagnosis of a representative sample of pediatric and adult CD patients of Gaza strip in light of DQ2 and DQ8 haplotypes expression. METHODS: Unrelated CD patients (n = 101) and matched healthy controls (n = 97) were genotyped for DQA1*05, DQB1*02 and DQB1*03:02 alleles by allele-specific real-time PCR...
November 15, 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/29142392/quantitative-analysis-of-benzyl-isothiocyanate-in-salvadora-persica-extract-and-dental-care-herbal-formulations-using-reversed-phase-c18-high-performance-liquid-chromatography-method
#5
Maged Saad Abdel-Kader, Y T Kamal, Prawez Alam, Mohammed Hamed Alqarni, Ahmed Ibrahim Foudah
Context: Benzyl isothiocyanate is the active antimicrobial agent in Salvadora persica (siwak) widely used in Islamic countries for oral hygiene. Aims: Quantification of benzyl isothiocyanate in the ethanol extract of S. persica and some dental care herbal formulations labeled to contain siwak. Settings and Design: Simple and sensitive high-performance liquid chromatography method was designed. Subjects and Methods: Separation was achieved on reverse phase C18 (250 mm × 4...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140883/mage-a4-and-mage-a1-immunohistochemical-expression-in-high-grade-endometrial-cancer
#6
Sanja Srdelić, Ivana Kuzmić-Prusac, Giulio C Spagnoli, Antonio Juretić, Vesna Čapkun
The aim was to investigate MAGE-A4 and MAGE-A1 protein expression in high-grade endometrial cancer and determine its correlation with histologic subtype, FIGO stage, presence of vascular invasion, disease free, and overall survival. Immunohistochemical staining was performed by using 77B (MAGE-A1) and 57B (MAGE-A4) monoclonal antibodies on paraffin-embedded sections from high-grade endometrial cancers diagnosed in University Hospital Split between 1998 and 2011 (n=77). Median follow-up time for survivors was 48 mo...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29140183/full-title-examining-the-presence-of-back-pain-in-competitive-athletes-a-focus-on-stress-and-recovery
#7
Jahan Heidari, Johanna Belz, Monika Hasenbring, Jens Kleinert, Claudia Levenig, Michael Kellmann
Context - Explanatory approaches for back pain (BP) in athletes focus on biomechanical factors while neglecting psychological perspectives. Psychological factors have gained importance in the prediction of injuries in athletes and BP in the general population, with stress and recovery emerging as central risk factors. However, scarce evidence exists regarding the role of these aspects for the prevalent burden of back pain (BP). Objective - To investigate the association between stress and recovery parameters and the presence of BP...
November 15, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29139575/developmental-links-between-gaming-and-depressive-symptoms
#8
Jakub Mikuška, Alexander T Vazsonyi
The current longitudinal study tested the reciprocal relationships between video game play and depressive symptoms among 9,421 adolescents from the Add Health (Mage  = 16.15 years, SD = 1.64, 55% female), over 11 years (Waves 2, 3, and 4), ages 16 to 27. Based on structural equation modeling as well as latent growth models, findings indicated that (1) excessive gaming was largely transient over time, from adolescence to early adulthood; (2) excessive gaming predicted increases in depressive symptoms; and (3) in turn, depressive symptoms predicted decreases in gaming over time...
November 15, 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29139038/the-impact-of-donor-and-recipient-weight-incompatibility-on-renal-transplant-outcomes
#9
Limy Wong, Aileen Counihan, Patrick O'Kelly, Donal J Sexton, Conall M O'Seaghdha, Colm Magee, Dilly Little, Peter J Conlon
BACKGROUND: Donor/recipient size mismatching and correlation to allograft outcome remains poorly defined. This study assessed the impact of donor body weight (DBW) to recipient body weight (RBW) ratio on allograft function and survival. METHODS: A total of 898 deceased donor renal transplant recipients were included in the study. Patients were divided into quartiles depending on the ratio of DBW/RBW: Q1 (≤ 0.88), Q2 (0.89-1.00), Q3 (1.01-1.22) and Q4 (> 1...
November 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29138811/high-expression-of-mage-a9-contributes-to-stemness-and-malignancy-of-human-hepatocellular-carcinoma
#10
Youping Wei, Yanqin Wang, Jing Gong, Lihua Rao, Zhiwei Wu, Teng Nie, Dongling Shi, Liming Zhang
MAGE-A9, a well-characterized cancer testis antigen (CTA), belongs to a member of melanoma antigen gene (MAGE) family. In human malignancies, aberrant expression of MAGE genes correlated with poor clinical prognosis, increased tumor growth, metastases, and enrichment in stem cell populations of certain cancers. Cancer stem cells (CSCs) have been proposed to contribute to the major malignant phenotypes of liver cancer, including recurrence, metastasis and chemoresistance. However, expression and potential role of MAGE-A9 in liver cancer stem cells (LCSCs) still remain unclear...
November 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29134622/development-of-gender-typicality-and-felt-pressure-in-european-french-and-north-african-french-adolescents
#11
Adam J Hoffman, Florence Dumas, Florence Loose, Annique Smeding, Beth Kurtz-Costes, Isabelle Régner
Trajectories of gender identity were examined from Grade 6 (Mage  = 11.9 years) to Grade 9 in European French (n = 570) and North African French (n = 534) adolescents, and gender and ethnic group differences were assessed in these trajectories. In Grade 6, boys of both ethnic groups reported higher levels of gender typicality and felt pressure for gender conformity than girls. European French girls and boys and North African French girls reported decreasing gender typicality from Grade 6 to Grade 9, whereas North African French boys did not change...
November 14, 2017: Child Development
https://www.readbyqxmd.com/read/29134253/the-role-of-the-neutrophil-lymphocyte-ratio-nlr-and-the-crp-albumin-ratio-car-in-predicting-mortality-following-emergency-laparotomy-in-the-over-80-age-group
#12
G Simpson, R Saunders, J Wilson, C Magee
INTRODUCTION: Emergency laparotomy in the elderly is an increasingly common procedure which carries high morbidity and mortality. Risk prediction tools, although imperfect, can help guide management decisions. Novel markers of surgical outcomes may contribute to these scoring systems. The neutrophil:lymphocyte ratio (NLR) and CRP:albumin ratio (CAR) have been associated with outcomes in malignancy and sepsis. We assessed the use of ratio NLR and CAR as prognostic indicators in patients over the age of 80 undergoing emergency laparotomy...
November 13, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29134055/influence-of-goal-contents-on-exercise-addiction-analysing-the-mediating-effect-of-passion-for-exercise
#13
Álvaro Sicilia, Manuel Alcaraz-Ibáñez, María-Jesús Lirola, Rafael Burgueño
Based on the self-determination theory (Deci and Ryan, 1985, 2000), the purpose of this study was to examine the effects of exercise goal contents on exercise addiction, taking into account the mediating effects of passion for exercise. A total of 384 university students (284 men and 100 women; Mage = 20.31, SD = 3.10) completed a questionnaire that measured exercise frequency and intensity, exercise goal contents (e.g. intrinsic: social affiliation, health management, skill development; extrinsic: image and social recognition), passion for exercise (e...
October 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29133857/pdgfr-modulated-mir-23b-cluster-and-mir-125a-5p-suppress-lung-tumorigenesis-by-targeting-multiple-components-of-kras-and-nf-kb-pathways
#14
Srivatsava Naidu, Lei Shi, Peter Magee, Justin D Middleton, Alessandro Laganá, Sudhakar Sahoo, Hui Sun Leong, Melanie Galvin, Kristopher Frese, Caroline Dive, Vincenza Guzzardo, Matteo Fassan, Michela Garofalo
In NSCLC alterations in PDGF receptors are markers of worst prognosis and efficient targeting of these receptors is yet to be achieved. In this study, we explored PDGFR-regulated microRNAs demonstrating that miR-23b cluster and miR-125a-5p are downregulated by increased expression of PDGFR-α or PDGFR-β in NSCLC cells. Mechanistically, the expression of these microRNAs is positively regulated by p53 and negatively modulated by NF-kB p65. Forced expression of miR-23b cluster or miR-125a-5p enhanced drug sensitivity and suppressed invasiveness of NSCLC cells by silencing several genes involved in oncogenic KRAS and NF-kB pathways, including SOS1, GRB2, IQGAP1, RALA, RAF-1, IKKβ, AKT2, ERK2 and KRAS itself...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131662/isoniazid-monoresistance-and-rate-of-culture-conversion-among-confirmed-tuberculosis-patients-in-the-state-of-georgia-2009-2014
#15
Argita D Salindri, Rose-Marie F Sales, Lauren DiMiceli, Marcos C Schechter, Russell R Kempker, Matthew J Magee
RATIONALE: Isoniazid-monoresistant tuberculosis (INH-monoresistant TB) is the most common drug-resistant TB type in the US; however, its impact on TB treatment outcomes is not clear. OBJECTIVES: This study aims to understand: 1) factors associated with INH-monoresistant TB and 2) the association between INH-monoresistance and response to TB treatment. METHODS: We studied all patients with TB aged ≥15 years reported to the Georgia State Electronic Notifiable Disease Surveillance System (SENDSS) from 2009-2014...
November 13, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29130603/proteogenomic-re-annotation-of-coccidioides-posadasii-strain-silveira
#16
Natalie M Mitchell, Andrew L Sherrard, Surendra Dasari, D Mitchell Magee, Thomas E Grys, Douglas F Lake
The aims of this study were to provide protein-based evidence upon which to re-annotate of the genome of C. posadasii, one of two closely related species of Coccidioides, a dimorphic fungal pathogen that causes coccidioidomycosis, also called Valley Fever. Proteins present in lysates and filtrates of in vitro grown mycelia and parasitic phase spherules from C. posadasii strain Silveira were analyzed using a GeLC-MS/MS method. Acquired spectra were processed with a proteogenomics workflow comprising a Silveira proteome database, a 6-frame translation of the Silveira genome and an ab initio gene prediction tool prior to validation against published ESTs...
November 12, 2017: Proteomics
https://www.readbyqxmd.com/read/29130427/reduction-of-anxiety-sensitivity-in-relation-to-nicotine-withdrawal-symptoms-during-smoking-cessation-an-examination-among-successful-quitters
#17
Jafar Bakhshaie, Michael J Zvolensky, Kirsten J Langdon, Adam M Leventhal, Norman B Schmidt
Anxiety sensitivity has been implicated as a potential risk factor for post-quit withdrawal symptoms. The present study examined relations between the extent of change in anxiety sensitivity and the course of nicotine withdrawal symptoms experienced during the initial two weeks of a quit attempt among treatment-seeking smokers. The sample consisted of 29 adult daily smokers (34% female; Mage = 47.7, SD = 13.1) who successfully quit and maintained their abstinence. After adjusting for the effects of gender, treatment condition, use of nicotine replacement therapy, nicotine dependence, alcohol use problems, baseline levels of anxiety sensitivity, and reductions in negative affect, greater reductions in anxiety sensitivity were related to faster decreases in withdrawal symptoms...
November 13, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/29127938/caregiver-feeding-practices-and-weight-status-among-african-american-adolescents-the-jackson-heart-kids-pilot-study
#18
E Thomaseo Burton, Tanganyika Wilder, Bettina M Beech, Marino A Bruce
Adolescence is a stage in the life course during which youth become more autonomous in their health behaviors. Overweight and obesity during this developmental period are associated with short- and long-term physical and emotional morbidity, and African American youth are at pronounced risk for these health outcomes. The style of parenting employed by caregivers influences health behaviors in children, though the persistence of this influence into adolescence is not clear. This study examined associations among caregiver feeding practices, body mass index z-score (zBMI), and waist circumference (WC) in a cohort of 212 African American adolescents (50...
November 6, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/29126897/self-efficacy-and-physical-activity-among-adults-with-visual-impairments
#19
Justin A Haegele, T Nicole Kirk, Xihe Zhu
BACKGROUND: According to empirical evidence, adults with visual impairments are generally less physically active than their sighted peers, however less is known about what specific motivational factors influence physical activity participation among this population. While research has identified self-efficacy as one important motivational factor for physical activity, no previous research has examined this association among individuals with visual impairments. OBJECTIVE: The primary purpose of the current study was to examine the association between self-efficacy and physical activity for adults with visual impairments...
October 31, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29125781/shyness-and-social-anxiety-assessed-through-self-report-what-are-we-measuring
#20
Christina A Brook, Teena Willoughby
The distinction between shyness and social anxiety remains unclear in the literature. In an attempt to shed further light on this issue, our research evaluated whether shyness and social anxiety were the same construct underlying various measurement scales. Participants (N = 801, Mage = 36.21, range = 18-74, female = 53.10%) responded to 10 questionnaires assessing either shyness or social anxiety. Evidence indicated that the scales were highly correlated and loaded onto 1 factor. Confirmatory factor analysis corroborated this finding...
November 10, 2017: Journal of Personality Assessment
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