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https://www.readbyqxmd.com/read/27903835/identification-of-microrna-signature-and-potential-pathway-targets-in-prostate-cancer
#1
Ahmed A Moustafa, Mohammed Ziada, Abubaker Elshaikh, Amrita Datta, Hogyoung Kim, Krzysztof Moroz, Sudesh Srivastav, Raju Thomas, Jonathan L Silberstein, Krishnarao Moparty, Fatma Elzahraa H Salem, Ola H El-Habit, Asim B Abdel-Mageed
Prostate cancer (PC) is the most common and the second leading cause of cancer-related death among American men. Early diagnosis is a prerequisite to improving therapeutic benefits. However, the current clinical biomarkers for PC do not reliably decipher indolent PC from other urogenital disorders. Thus, effective clinical intervention necessitates development of new biomarkers for early detection of PC. The present study aimed to identify the miRNA signature in organ-confined (Gleason Score 6) prostate tumors...
November 29, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27902891/computerized-agility-training-improves-change-of-direction-and-balance-performance-independently-of-footwear-in-young-adults
#2
Max R Paquette, Brian K Schilling, Joshua D Bravo, Shelby A Peel, Yuhua Li, Robert J Townsend
: Understanding the effects of training in different footwear on sporting performance would be useful to coaches and athletes. PURPOSE: This study compared the effects of computerized agility training using 3 types of footwear on change-of-direction and balance performance in young adults. METHOD: Thirty recreationally active young adults (Mage = 22.8 ± 3.1 years; Mheight = 1.71 ± 0.7 m; Mbodymass = 73.4 ± 10.3 kg) were randomly assigned to a 6-week computerized agility training intervention in 1 of 3 footwear groups (n = 10/group): barefoot, minimal footwear, or traditional shoes...
November 30, 2016: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/27899030/childhood-vaccine-refusal-and-hesitancy-intentions-in-croatia-insights-from-a-population-based-study
#3
Anja Repalust, Sandra Šević, Stanko Rihtar, Aleksandar Štulhofer
Considering that programmatic data suggest a recent rise in vaccine refusal in Croatia, this study, first of its kind in Southeast Europe, aimed to estimate the prevalence, and sociodemographic, and sociocultural determinants of childhood vaccine refusal and hesitancy (CVRH) intentions among Croatian adults. Multi-stage stratified population-based survey included 1000 individuals aged 18-88 years (Mage = 47.7, SD = 17.8), of whom 51.7% were women. The outcome, a categorical indicator, distinguished among individuals who would approve vaccinating their children (vaccine accepting), those who would approve some but not all vaccines (vaccine hesitant), and those who would refuse vaccination (vaccine refusing)...
November 29, 2016: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/27894764/thoracoscopic-bilateral-t3-sympathectomy-for-primary-focal-hyperhidrosis-in-children
#4
Pablo Laje, Kali Rhodes, Leanne Magee, Mary Kate Klarich
AIM OF THE STUDY: Present our experience in the surgical treatment of primary focal hyperhidrosis of the hands by thoracoscopic bilateral T3 sympathectomy in pediatric patients. METHODS: Retrospective chart review of all patients operated between 2013 and 2015. RESULTS: We operated and included in the study 28 patients, 22 females and 6 males. Mean age was 14 (6-21) years. All patients had previously tried at least one form of medical therapy with no success...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27893993/mediated-effects-of-perceived-discrimination-on-adolescent-academic-achievement-a-test-of-four-models
#5
William Hood, Graham L Bradley, Samantha Ferguson
Many adolescents feel they are subjected to acts of discrimination. Research shows that discrimination is associated with adverse outcomes including poor psychological adjustment, school adjustment, and academic achievement. This study investigated alternative pathways through which discrimination affects adolescents' academic achievement. A sample of 244 Year 7-10 Australian secondary school students (65% male; Mage = 13.6 years; SD = 1.24) completed questionnaires measuring discrimination, psychological adjustment, and sense of school membership...
November 25, 2016: Journal of Adolescence
https://www.readbyqxmd.com/read/27893245/the-quest-for-identity-in-adolescence-heterogeneity-in-daily-identity-formation-and-psychosocial-adjustment-across-5-years
#6
Andrik I Becht, Stefanie A Nelemans, Susan J T Branje, Wilma A M Vollebergh, Hans M Koot, Jaap J A Denissen, Wim H J Meeus
Identity formation is one of the key developmental tasks in adolescence. According to Erikson (1968) experiencing identity uncertainty is normative in adolescence. However, empirical studies investigating identity uncertainty on a daily basis are lacking. Hence, studying individual differences in daily certainty (i.e., identity commitment levels) and uncertainty (i.e., identity commitment fluctuations and identity reconsideration) in the identity formation process may advance our knowledge about the extent to which adolescents' identity uncertainty is part of normative identity development...
December 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27893238/does-anger-regulation-mediate-the-discrimination-mental-health-link-among-mexican-origin-adolescents-a-longitudinal-mediation-analysis-using-multilevel-modeling
#7
Irene J K Park, Lijuan Wang, David R Williams, Margarita Alegría
Although prior research has consistently documented the association between racial/ethnic discrimination and poor mental health outcomes, the mechanisms that underlie this link are still unclear. The present 3-wave longitudinal study tested the mediating role of anger regulation in the discrimination-mental health link among 269 Mexican-origin adolescents (Mage = 14.1 years, SD = 1.6; 57% girls), 12 to 17 years old. Three competing anger regulation variables were tested as potential mediators: outward anger expression, anger suppression, and anger control...
November 28, 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27892806/wisconsin-card-sorting-test-embedded-validity-indicators-developed-for-adults-can-be-extended-to-children
#8
Jonathan D Lichtenstein, Laszlo A Erdodi, Jaspreet K Rai, Anya Mazur-Mosiewicz, Lloyd Flaro
Past studies have examined the ability of the Wisconsin Card Sorting Test (WCST) to discriminate valid from invalid performance in adults using both individual embedded validity indicators (EVIs) and multivariate approaches. This study is designed to investigate whether the two most stable of these indicators-failures to maintain set (FMS) and the logistical regression equation S-BLRE-can be extended to pediatric populations. The classification accuracy for FMS and S-BLRE was examined in a mixed clinical sample of 226 children aged 7 to 17 years (64...
November 28, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/27888016/post-transplantation-cyclophosphamide-and-ixazomib-combination-rescues-mice-subjected-to-experimental-gvhd-and-is-superior-to-either-agent-alone
#9
A Samer Al-Homsi, Austin Goodyke, Michael McLane, Sarah Abdel-Mageed, Kelli Cole, Marlee Muilenburg, Yuxin Feng
Lapses in the prevention of graft-versus-host disease (GvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) warrants novel approaches. Such approaches include, among others, the use of post-transplantation cyclophosphamide (PTC) and proteasome inhibitors. Although PTC alone consistently produces low rates of chronic GvHD, the incidence of acute GvHD remains significant. Inversely, prolonged post-transplantation administration of proteasome inhibitors carries a risk of paradoxical aggravation of GvHD...
November 22, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27886565/investigating-the-relationship-between-reduced-self-awareness-of-falls-risk-rehabilitation-engagement-and-falls-in-older-adults
#10
Tijana Mihaljcic, Terry P Haines, Jennie L Ponsford, Renerus J Stolwyk
The present study aimed to investigate whether self-awareness of falls risk is associated with rehabilitation engagement, motivation for rehabilitation, and number of falls after hospital discharge. The sample comprised 91 older adults (Mage=77.97, SD=8.04) undergoing inpatient rehabilitation. The Self-Awareness of Falls Risk Measure (SAFRM) was used to measure different aspects of self-awareness. The treating physiotherapist and occupational therapist rated the patient's engagement in rehabilitation and the patient reported his/her motivation for treatment...
November 16, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27885691/psychological-need-satisfaction-control-and-disordered-eating
#11
Franzisca V Froreich, Lenny R Vartanian, Matthew J Zawadzki, Jessica R Grisham, Stephen W Touyz
OBJECTIVES: Unfulfilled basic psychological needs have been associated with disordered eating behaviours, but the mechanisms underlying that associations are not well understood. This study examined a two-stage path model linking basic psychological need satisfaction to disordered eating behaviours via issues of control. METHODS: Female university students (N = 323; Mage  = 19.61), community participants (N = 371; Mage  = 29.75), and women who self-reported having been diagnosed with an eating disorder (ED; N = 41; Mage  = 23...
November 24, 2016: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27884039/clarifying-the-links-of-conscientiousness-with-internalizing-and-externalizing-psychopathology
#12
Kristin Naragon-Gainey, Leonard J Simms
OBJECTIVE: Although conscientiousness/disinhibition plays a substantial role in internalizing and externalizing psychopathology, the underlying mechanisms are not well-understood. We aim to clarify facet-level associations, and to examine whether (a) impairment mediates the link of conscientiousness with internalizing and externalizing symptoms, and (b) demoralization (assessed via neuroticism) accounts for their associations. METHOD: 450 participants (Mage =42; primarily female and Caucasian) who reported current/recent psychiatric treatment completed two measures of domain and facet-level traits (i...
November 24, 2016: Journal of Personality
https://www.readbyqxmd.com/read/27882458/personal-identity-development-in-hispanic-immigrant-adolescents-links-with-positive-psychosocial-functioning-depressive-symptoms-and-externalizing-problems
#13
Seth J Schwartz, Jennifer B Unger, Alan Meca, Elma I Lorenzo-Blanco, Lourdes Baezconde-Garbanati, Miguel Ángel Cano, Brandy Piña-Watson, José Szapocznik, Byron L Zamboanga, David Córdova, Andrea J Romero, Tae Kyoung Lee, Daniel W Soto, Juan A Villamar, Karina M Lizzi, Sabrina E Des Rosiers, Monica Pattarroyo
The present study was designed to examine trajectories of personal identity coherence and confusion among Hispanic recent-immigrant adolescents, as well as the effects of these trajectories on psychosocial and risk-taking outcomes. Personal identity is extremely important in anchoring young immigrants during a time of acute cultural change. A sample of 302 recently immigrated (5 years or less in the United States at baseline) Hispanic adolescents (Mage = 14.51 years at baseline; SD = 0.88 years, range 14-17) from Miami and Los Angeles (47 % girls) completed measures of personal identity coherence and confusion at the first five waves of a six-wave longitudinal study; and reported on positive psychosocial functioning, depressive symptoms, and externalizing problems at baseline and at Time 6...
November 23, 2016: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/27882107/effects-of-sitagliptin-as-initial-therapy-in-newly-diagnosed-elderly-type-2-diabetics-a-randomized-controlled-study
#14
Xiaoyan Xiao, Xiaopei Cui, Jianbo Zhang, Zhenxia Han, Yu Xiao, Nan Chen, Baoying Li, Mei Cheng, Haiqing Gao, Kuanxiao Tang
The objective of this study was to investigate the characteristics of blood glycemic excursion, incretins and pancreatic hormone secretion in elderly people with newly diagnosed type 2 diabetes mellitus (T2DM) and to study the effects of sitagliptin on glycemic excursion in these subjects. A total of 129 newly diagnosed T2DM patients were enrolled in the study from March 2012 to August 2013. Clinical data, serum incretin, pancreatic hormone and continuous glucose monitoring data were collected. Among these subjects, elderly patients (NEDM) randomly received metformin combined with sitagliptin phosphate or glimepiride for 24 weeks...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27880629/suicidal-ideation-and-interpersonal-needs-factor-structure-of-a-short-version-of-the-interpersonal-needs-questionnaire-in-an-at-risk-military-sample
#15
Nicholas P Allan, Daniel F Gros, Melanie A Hom, Thomas E Joiner, Tracy Stecker
OBJECTIVE: The interpersonal-psychological theory of suicide posits that perceived burdensomeness (PB; i.e., the belief that others would be better off if one were dead) and thwarted belongingness (TB; i.e., the belief that one lacks meaningful social connections) are both necessary risk factors for the development of suicidal ideation. To test these relations, measures are needed that are well validated, especially in samples of at-risk adults. METHOD: The current study was designed to examine the factor structure of an eight-item version of the Interpersonal Needs Questionnaire (INQ) in a sample of 405 U...
2016: Psychiatry
https://www.readbyqxmd.com/read/27880034/synthesis-of-monoalkyl-glyceryl-ethers-by-ring-opening-of-glycidol-with-alcohols-in-the-presence-of-lewis-acids
#16
Raffaele Cucciniello, Maria Ricciardi, Rosa Vitiello, Martino Di Serio, Antonio Proto, Carmine Capacchione
The present work deals with the production of monoalkyl glyceryl ethers (MAGEs) through a new reaction pathway based on the reaction of glycidol and alcohols catalyzed by Lewis acid-based catalysts. Glycidol is quantitatively converted with high selectivity (99 %) into MAGEs under very mild reaction conditions (80 °C and 0.01 mol % catalyst loading) in only 1 h using Al(OTf)3 or Bi(OTf)3 as catalyst. The proposed method enhances the choice of possible green synthetic approaches for the production of value-added products such as MAGEs...
November 23, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27879203/fetal-and-neonatal-hematopoietic-progenitors-are-functionally-and-transcriptionally-resistant-to-flt3-itd-mutations
#17
Shaina N Porter, Andrew S Cluster, Wei Yang, Kelsey A Busken, Riddhi M Patel, Jiyeon A Ryoo, Jeffrey A Magee
The FLT3 Internal Tandem Duplication (FLT3(ITD)) mutation is common in adult acute myeloid leukemia (AML) but rare in early childhood AML. It is not clear why this difference occurs. Here we show that Flt3(ITD) and cooperating Flt3(ITD)/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult but not fetal stages of murine development. In adult progenitors, FLT3(ITD) simultaneously induces self-renewal and myeloid commitment programs via STAT5-dependent and STAT5-independent mechanisms, respectively...
November 23, 2016: ELife
https://www.readbyqxmd.com/read/27878861/eus-guided-biopsy-using-a-franseen-needle-design-an-initial-assessment
#18
Ji Young Bang, Shantel Hebert-Magee, Muhammad K Hasan, Udayakumar Navaneethan, Robert Hawes, Shyam Varadarajulu
BACKGROUND AND AIM: Recently, a 22 gauge (G) needle with a Franseen tip design was developed for EUS-guided fine needle biopsy (EUS-FNB). This study evaluated the performance of the Franseen biopsy needle in EUS-guided tissue acquisition. METHODS: This is a retrospective study of patients who underwent EUS-FNB using the Franseen needle. Lesions were sampled either using only the Franseen needle or after failed diagnostic fine needle aspiration (FNA). After rapid onsite evaluation (ROSE), two dedicated passes were performed for histological assessment using the cell block technique...
November 23, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27876353/autologous-stem-cell-transplantation-promotes-mechanical-stretch-induced-skin-regeneration-a-randomized-phase-i-ii-clinical-trial
#19
Shuang-Bai Zhou, Guo-You Zhang, Yun Xie, Tao Zan, Yao-Kai Gan, Caroline A Yao, Cheng-An Chiang, Jing Wang, Kai Liu, Hua Li, Jia Zhou, Mei Yang, Bin Gu, Feng Xie, Lee Q Pu, William P Magee, Qing-Feng Li
BACKGROUND: Mechanical stretch, in term of skin expansion, can induce effective but limited in vivo skin regeneration for complex skin defect reconstruction. We propose a strategy to obtain regenerated skin by combining autologous stem cell transplantation with mechanical stretch. METHODS: This randomized, blinded placebo-controlled trial enrolled 38 adult patients undergoing skin expansion presenting with signs of exhausted regenerative capacity. Patients randomly received autologous bone marrow mononuclear cell (MNC) or placebo injections intradermally...
October 1, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27875750/how-children-s-victimization-relates-to-distorted-versus-sensitive-social-cognition-perception-mood-and-need-fulfillment-in-response-to-cyberball-inclusion-and-exclusion
#20
Tessa A M Lansu, Tirza H J van Noorden, Marike H F Deutz
This study examined whether victimization is associated with negatively distorted social cognition (bias), or with a specific increased sensitivity to social negative cues, by assessing the perception of social exclusion and the consequences for psychological well-being (moods and fundamental needs). Both self-reported and peer-reported victimization of 564 participants (Mage=9.9years, SD=1.04; 49.1% girls) were measured, and social exclusion was manipulated through inclusion versus exclusion in a virtual ball-tossing game (Cyberball)...
November 19, 2016: Journal of Experimental Child Psychology
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