Read by QxMD icon Read


Xin Li, Goran Papenberg, Grégoria Kalpouzos, Lars Bäckman, Jonas Persson
Dopaminergic neuromodulation is critically important for brain and cognitive integrity. The DRD2/ANKK1 Taq1A polymorphism is associated with striatal dopamine (DA) D2 receptor availability. Some previous studies have found that the A allele of the Taq1A polymorphism influences brain structure, but the results are inconsistent, likely due to population heterogeneity and small sample sizes. We investigated the genetic effect on caudate volume in a large sample of older adults without dementia. Results show that A-allele carriers have smaller caudate volume compared to non-carriers in relatively older adults (n = 167; Mage = 77...
March 21, 2018: Brain Structure & Function
Yoko Motokawa, Michifumi Kokubo, Nobuo Kuwabara, Ken-Ichiro Tatematsu, Hideki Sezutsu, Hideyuki Takahashi, Koichi Sakakura, Kazuaki Chikamatsu, Shigeki Takeda
Recent clinical trials with the aim of developing tumor antigen (TA)-specific cancer vaccines against a number of malignancies have focused on the identification of TAs presented by tumor cells and recognized by T cells. In the present study, the TA melanoma antigen family A4 (MAGE-A4) protein was produced using a transgenic (TG) silkworm system. Using in vitro stimulation, it was subsequently determined whether MAGE-A4 protein induced MAGE-A4-specific T cells from peripheral blood mononuclear cells of healthy donors...
March 2018: Experimental and Therapeutic Medicine
Michal T Kucewicz, Jaromir Dolezal, Vaclav Kremen, Brent M Berry, Laura R Miller, Abigail L Magee, Vratislav Fabian, Gregory A Worrell
Pupil responses are known to indicate brain processes involved in perception, attention and decision-making. They can provide an accessible biomarker of human memory performance and cognitive states in general. Here we investigated changes in the pupil size during encoding and recall of word lists. Consistent patterns in the pupil response were found across and within distinct phases of the free recall task. The pupil was most constricted in the initial fixation phase and was gradually more dilated through the subsequent encoding, distractor and recall phases of the task, as the word items were maintained in memory...
March 21, 2018: Scientific Reports
Samantha G Farris, Angelo M DiBello, Erika Litvin Bloom, Ana M Abrantes
INTRODUCTION: The Smoking and Weight Eating Episodes Test (SWEET; Adams et al. 2011) is a self-report measure designed to assess multiple reasons why and when smokers use cigarettes for appetite, weight, and shape management, that was initially developed and validated in young female smokers. PURPOSE: The aim of the current study was to evaluate the factor structure and psychometric properties of the SWEET measure among both male and female daily cigarette smokers...
March 20, 2018: International Journal of Behavioral Medicine
Lorra Garey, Lorraine R Reitzel, Julie Neisler, Darla E Kendzor, Michael J Zvolensky, Clayton Neighbors, Daphne C Hernandez, Michael S Businelle
PURPOSE: Health-related quality of life (HRQoL) is a multidimensional assessment of well-being and health status. Most previous work in this area assumes that HRQoL is a homogenous construct; however, it is possible HRQoL subgroups may exist. The purpose of the study was to characterize common classes of HRQoL among adult, homeless smokers, a particularly vulnerable group of the larger population, and to evaluate risk and protective factors of HRQoL class membership. METHODS: Homeless smokers (N = 456; 65...
March 20, 2018: Behavioral Medicine
Andrew H Rogers, Jafar Bakhshaie, Nubia A Mayorga, Joseph W Ditre, Michael J Zvolensky
Pain and pain related problems affect a significant proportion of the United States population. Past research suggests that emotional distress is associated with more severe and disabling pain experience. Yet, it is less clear how individual reactions to distress are related to pain experience. Distress tolerance, defined as the perceived ability to withstand cognitive, affective, or physical distress, is an individual difference factor that may be particularly important to understanding the experience of pain...
March 20, 2018: Psychology, Health & Medicine
Kerri M Malone, Kévin Rue-Albrecht, David A Magee, Kevin Conlon, Olga T Schubert, Nicolas C Nalpas, John A Browne, Alicia Smyth, Eamonn Gormley, Ruedi Aebersold, David E MacHugh, Stephen V Gordon
Members of the Mycobacterium tuberculosis complex (MTBC) are the causative agents of tuberculosis in a range of mammals, including humans. A key feature of MTBC pathogens is their high degree of genetic identity yet distinct host tropism. Notably, while Mycobacterium bovis is highly virulent and pathogenic for cattle, the human pathogen M. tuberculosis is attenuated in cattle. Previous research also suggests that host preference amongst MTBC members has a basis in host innate immune responses. To explore MTBC host tropism, we present in-depth profiling of the MTBC reference strains M...
March 20, 2018: Microbial Genomics
Selma Lugtmeijer, Edward H F de Haan, Roy P C Kessels
Working memory and episodic memory decline with age.  However, as they are typically studied separately, it is largely unknown whether age-associated differences are similar. A task design was developed in which visual working memory and episodic memory performances were measured using the same stimuli, with both tasks involving context binding. A 2-back working memory task was followed by a surprise subsequent recognition memory task that assessed incidental encoding of object locations of the 2-back task...
March 20, 2018: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Sarah J Brislin, Christopher J Patrick, Herta Flor, Frauke Nees, Angela Heinrich, Laura E Drislane, James R Yancey, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Patricia Conrod, Argyris Stringaris, Maren Struve, Betteke van Noort, Yvonne Grimmer, Tahmine Fadai, Gunter Schumann, Jens Foell
Trait disinhibition, a clinical-liability construct, has well-established correlates in the diagnostic, self-rating, task-behavioral, and brain potential response domains. Recently, studies have begun to test for neuroimaging correlates of this liability factor, but more work of this type using larger data sets is needed to clarify its brain bases. The current study details the development and validation of a scale measure of trait disinhibition composed of questionnaire items available in the IMAGEN project, a large-scale longitudinal study of factors contributing to substance abuse that includes clinical interview, self-report personality, task-behavioral, neuroimaging, and genomic measures...
March 1, 2018: Assessment
Laura Vandenbosch, Johanna M F van Oosten
Despite increasing interest in the implications of adolescents' use of sexually explicit Internet material (SEIM), we still know little about the relationship between SEIM use and adolescents' casual sexual activities. Based on a three-wave online panel survey study among Dutch adolescents (N = 1079; 53.1% boys; 93.5% with an exclusively heterosexual orientation; Mage  = 15.11; SD = 1.39), we found that watching SEIM predicted engagement in casual sex over time. In turn, casual sexual activities partially predicted adolescents' use of SEIM...
March 19, 2018: Archives of Sexual Behavior
Till J Meyer, Stefan Hartmann, Gisela Wohlleben, Muna Brisam, Axel Seher, Alexander C Kübler, Bülent Polat, Urs D A Müller-Richter
Radiotherapy alone, or as an addition to surgery is important for the treatment of head and neck squamous cell carcinoma (HNSCC). In addition to their expression in germ cells, melanoma associated antigens-A (MAGE-A) are only expressed in malignant tissue. Notably, there is a known correlation between MAGE-A9 expression and poor prognosis in HNSCC patients. However, current knowledge regarding the function of MAGE-A9 expression, particularly in the context of irradiation, is limited. MAGE-A9 expression in 37 oral squamous cell carcinoma patents was immunohistochemically determined and analyzed for overall survival by the Kaplan-Meier log-rank test...
March 2018: Molecular and Clinical Oncology
Sarah Blunden, Chris Magee, Kelly Attard, Larissa Clarkson, Peter Caputi, Timothy Skinner
BACKGROUND: Sleep duration and sleep schedule variability have been related to negative health and well-being outcomes in children, but little is known about Australian Indigenous children. METHODS: Data for children aged 7-9 years came from the Australian Longitudinal Study of Indigenous Children and the National Assessment Program-Literacy and Numeracy (NAPLAN). Latent class analysis determined sleep classes taking into account sleep duration, bedtimes, waketimes, and variability in bedtimes from weekdays to weekends...
April 2018: Sleep Health
Axel de Zélicourt, Lukas Synek, Maged M Saad, Hanin Alzubaidy, Rewaa Jalal, Yakun Xie, Cristina Andrés-Barrao, Eleonora Rolli, Florence Guerard, Kiruthiga G Mariappan, Ihsanullah Daur, Jean Colcombet, Moussa Benhamed, Thomas Depaepe, Dominique Van Der Straeten, Heribert Hirt
Several plant species require microbial associations for survival under different biotic and abiotic stresses. In this study, we show that Enterobacter sp. SA187, a desert plant endophytic bacterium, enhances yield of the crop plant alfalfa under field conditions as well as growth of the model plant Arabidopsis thaliana in vitro, revealing a high potential of SA187 as a biological solution for improving crop production. Studying the SA187 interaction with Arabidopsis, we uncovered a number of mechanisms related to the beneficial association of SA187 with plants...
March 19, 2018: PLoS Genetics
Joni A Mettler, Dillon M Magee, Barbara M Doucet
PURPOSE: Neuromuscular electrical stimulation (NMES) is commonly used in rehabilitation settings to increase muscle mass and strength. However, the effects of NMES on muscle growth are not clear and no human studies have compared anabolic signaling between low-frequency (LF-) and high-frequency (HF-) NMES. The purpose of this study was to determine the skeletal muscle anabolic signaling response to an acute bout of LF- and HF-NMES. METHODS: Eleven young healthy volunteers (6 men; 5 women) received an acute bout of LF- (20 Hz) and HF- (60 Hz) NMES...
March 16, 2018: Medicine and Science in Sports and Exercise
Nathan T Kearns, Warren T Jackson, Timothy R Elliott, Tiffany Ryan, Trey W Armstrong
PURPOSE/OBJECTIVE: The present study examines associations between levels of limb loss (partial hand vs. higher levels of limb loss) and eight clinically relevant measures of functional impairment, psychological well-being, and substance use. Research Method/Design: A cross-sectional, multisite study conducted at seven prosthetic rehabilitation centers across the United States. A total of 305 participants with upper limb loss (Mage = 44.28, SD = 15.45; 68.5% male; 70.5% white) completed orally administered self-assessments of pain interference, perceived activity restrictions, posttraumatic stress disorder (PTSD), depression, emotional reaction to their physical condition, problematic alcohol use, prescription medication overuse, and illicit drug use...
February 2018: Rehabilitation Psychology
Satomi Sonoda, Yosuke Okada, Hiroko Mori, Fumi Uemura, Kei Sugai, Maiko Hajime, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto, Yoshiya Tanaka
The aim of this retrospective study was to elucidate the association between glucose profile using the continuous glucose monitoring system (CGMS) and microvascular complications in patients with type 2 diabetes mellitus (T2DM). The subjects were 160 inpatients with T2DM. The mean blood glucose (MBG) level, percentage of time in a 24-hour period spent with blood glucose level higher than 180 mg/dl (time at >180 mg/dl), standard deviation (SD), and mean amplitude of glycemic excursions (MAGE) were measured continuously over 48 hours using the CGMS...
2018: Journal of UOEH
Nelli Lyyra, Raili Välimaa, Jorma Tynjälä
AIM: The first aim of this study was to explore the prevalence of loneliness and subjective health complaints (SHCs) among school-aged children in Finland. The second aim was to analyse to what extent perceived loneliness explains any variance in SHCs among school-aged children. METHOD: A representative sample of 5925 Finnish children and adolescents from grades 5 ( Mage =11.8 years), 7 ( Mage =13.8) and 9 ( Mage =15.8) completed the Health Behaviour in School-aged Children (HBSC) survey...
February 2018: Scandinavian Journal of Public Health
Fengyan Deng, Nancy Magee, Yuxia Zhang
Cell-to-cell communication is a fascinating process that is essential for maintaining tissue and whole-body homeostasis. Extracellular vesicles (EVs) are cell-derived membrane-bound nanoparticles that are a means of communication between cells. Accumulating evidence indicates that EVs can render either beneficial or harmful outcomes, depending on the specific cargos (e.g. proteins, lipids, RNAs) transferred between cells. EVs also have great value as diagnostic and prognostic markers of disease because they are present in a variety of biological fluids and carry bioactive molecules from their cells or tissues of origin...
September 2017: Liver Research
Katharina Förster, Silke Jörgens, Tracy M Air, Christian Bürger, Verena Enneking, Ronny Redlich, Dario Zaremba, Dominik Grotegerd, Katharina Dohm, Susanne Meinert, Elisabeth J Leehr, Joscha Böhnlein, Jonathan Repple, Nils Opel, Erhan Kavakbasi, Volker Arolt, Pienie Zwitserlood, Udo Dannlowski, Bernhard T Baune
To understand how cognitive dysfunction contributes to social cognitive deficits in depression, we investigated the relationship between executive function and social cognitive performance in adolescents and young adults during current and remitted depression, compared to healthy controls. Social cognition and executive function were measured in 179 students (61 healthy controls and 118 patients with depression; Mage = 20.60 years; SDage = 3.82 years). Hierarchical regression models were employed within each group (healthy controls, remitted depression, current depression) to examine the nature of associations between cognitive measures...
February 22, 2018: Psychiatry Research
Emily L Zale, Tessa J Heinhuis, Tara Tehan, Danielle Salgueiro, Jonathan Rosand, Ana-Maria Vranceanu
OBJECTIVE: Every year, millions of Americans become informal caregivers to loved ones admitted to Neuroscience Intensive Care Units (Neuro-ICU), and face challenges to Quality of Life (QoL). This study sought to identify associations between resiliency, distress, and caregiver QoL at time of Neuro-ICU admission. METHODS: Informal caregivers (N = 79, Mage  = 53, 64% female) of Neuro-ICU patients were recruited and completed self-report questionnaires during the hospitalization...
March 6, 2018: General Hospital Psychiatry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"