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Ambulatory infusion pump

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https://www.readbyqxmd.com/read/28632675/intermittent-bolus-injection-via-peripheral-nerve-catheters-may-exceed-occlusion-pressure-limit-of-an-ambulatory-infusion-pump-an-in-vitro-study
#1
Jeremy H Tsui, Wendy Ma, Ban C H Tsui
No abstract text is available yet for this article.
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28542568/nesfatin-1-like-peptide-is-a-novel-metabolic-factor-that-suppresses-feeding-and-regulates-whole-body-energy-homeostasis-in-male-wistar-rats
#2
Kavishankar Gawli, Naresh Ramesh, Suraj Unniappan
Nucleobindin-1 has high sequence similarity to nucleobindin-2, which encodes the anorectic and metabolic peptide, nesfatin-1. We previously reported a nesfatin-1-like peptide (NLP), anorectic in fish and insulinotropic in mice islet beta-like cells. The main objective of this research was to determine whether NLP is a metabolic regulator in male Wistar rats. A single intraperitoneal (IP) injection of NLP (100 μg/kg BW) decreased food intake and increased ambulatory movement, without causing any change in total activity or energy expenditure when compared to saline-treated rats...
2017: PloS One
https://www.readbyqxmd.com/read/28379519/the-effect-of-a-subcutaneous-infusion-of-glp-1-oxm-and-pyy-on-energy-intake-and-expenditure-in-obese-volunteers
#3
Tricia Tan, Preeshila Behary, George Tharakan, James Minnion, Werd Al-Najim, Nicolai J Wewer Albrechtsen, Jens J Holst, Stephen R Bloom
Background: Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment for obesity, although limited by availability and operative risk. The gut hormones Glucagon-like peptide-1 (GLP-1), Peptide YY (PYY) and Oxyntomodulin (OXM) are elevated post-prandially after RYGB, which has been postulated to contribute to its metabolic benefits. Objective: We hypothesised that infusion of the three gut hormones to achieve levels similar to those encountered post-prandially in RYGB patients might be effective in suppressing appetite...
April 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27749354/continuous-peripheral-nerve-blocks-an-update-of-the-published-evidence-and-comparison-with-novel-alternative-analgesic-modalities
#4
REVIEW
Brian M Ilfeld
A continuous peripheral nerve block (CPNB) consists of a percutaneously inserted catheter with its tip adjacent to a target nerve/plexus through which local anesthetic may be administered, providing a prolonged block that may be titrated to the desired effect. In the decades after its first report in 1946, a plethora of data relating to CPNB was published, much of which was examined in a 2011 Anesthesia & Analgesia article. The current update is an evidence-based review of the CPNB literature published in the interim...
January 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27621142/early-detection-of-infusion-set-failure-during-insulin-pump-therapy-in-type-1-diabetes
#5
Marzia Cescon, Daniel J DeSalvo, Trang T Ly, David M Maahs, Laurel H Messer, Bruce A Buckingham, Francis J Doyle, Eyal Dassau
BACKGROUND: Insulin infusion set failure resulting in prolonged hyperglycemia or diabetic ketoacidosis can occur with pump therapy in type 1 diabetes. Set failures are frequently characterized by variable and unpredictable patterns of increasing glucose values despite increased insulin infusion. Early detection may minimize the risk of prolonged hyperglycemia, an important consideration for automated insulin delivery and closed-loop applications. METHODS: A novel algorithm designed to alert the patient to the onset of infusion set failure was developed based upon continuous glucose sensor values and insulin delivered from an insulin pump...
November 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27433423/postoperative-pain-control-with-the-fentanyl-patch-and-continuous-paravertebral-anesthetic-infusion-after-posterior-occipitocervical-junction-surgery
#6
Walavan Sivakumar, Michael Karsy, Andrea Brock, Richard H Schmidt
Postoperative pain is a significant concern for patients who undergo surgery via a midline posterior approach to the occipitocervical junction and spinal axis. The development of the disposable, ambulatory pain pump presents a novel alternative for treatment of postoperative pain. The authors describe a multimodal treatment algorithm for postoperative pain after posterior occipitocervical junction surgery that uses the On-Q pain catheter system (I-Flow Corp., Lake Forest, CA) and a fentanyl patch. The On-Q PainBuster catheter system is a disposable, ambulatory device that allows for continuous anesthetic delivery directly into or adjacent to the wound...
2016: Curēus
https://www.readbyqxmd.com/read/27104663/refractory-hypoglycemia-at-the-end-of-life-treated-with-continuous-dextrose-infusion-through-ambulatory-infusion-pump
#7
Benjamin T Galen
No abstract text is available yet for this article.
August 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/26869656/recap-detection-of-potentially-avoidable-harm-in-oncology-from-patient-medical-records
#8
Allison Lipitz-Snyderman, Saul N Weingart, Christopher Anderson, Andrew S Epstein, Aileen Killen, David Classen, Camelia S Sima, Elizabeth Fortier, Coral L Atoria, David Pfister, Allison Lipitz-Snyderman, Saul N Weingart, Christopher Anderson, Andrew S Epstein, Aileen Killen, David Classen, Camelia S Sima, Elizabeth Fortier, Coral L Atoria, David Pfister
PURPOSE: Widespread consensus exists about the importance of addressing patient safety issues in oncology, yet our understanding of the frequency, spectrum, and preventability of adverse events (AEs) across cancer care is limited. METHODS: We developed a screening tool to detect AEs across cancer care settings through medical record review. Members of the study team reviewed the scientific literature and obtained structured input from an external multidisciplinary panel of clinicians by using a modified Delphi process...
February 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/26862790/medical-management-of-pediatric-malignant-bowel-obstruction-in-a-patient-with-burkitt-s-lymphoma-and-ataxia-telangiectasia-using-continuous-ambulatory-drug-delivery-system
#9
Arunangshu Ghoshal, Naveen Salins, Anuja Damani, Jayita Deodhar, M A Muckaden
Malignant bowel obstruction (MBO) is commonly seen in patients with advanced abdominal cancers. The incidence of pediatric MBO in a patient with Burkitt's lymphoma and ataxia telangiectasia is rare, with no published case reports till now. Conservative management of inoperable MBO results in relief of symptoms and improves quality of life. An 11-year-old boy with Burkitt's lymphoma and ataxia telangiectasia was referred to pediatric palliative care with MBO. The objective of this report is to demonstrate conservative management of pediatric MBO using continuous ambulatory drug delivery system...
2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/26855476/a-wireless-implantable-micropump-for-chronic-drug-infusion-against-cancer
#10
Angelica Cobo, Roya Sheybani, Heidi Tu, Ellis Meng
We present an implantable micropump with a miniature form factor and completely wireless operation that enables chronic drug administration intended for evaluation and development of cancer therapies in freely moving small research animals such as rodents. The low power electrolysis actuator avoids the need for heavy implantable batteries. The infusion system features a class E inductive powering system that provides on-demand activation of the pump as well as remote adjustment of the delivery regimen without animal handling...
March 1, 2016: Sensors and Actuators. A, Physical
https://www.readbyqxmd.com/read/26848630/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-2016-outpatient-glucose-monitoring-consensus-statement
#11
Timothy S Bailey, George Grunberger, Bruce W Bode, Yehuda Handelsman, Irl B Hirsch, Lois Jovanovič, Victor Lawrence Roberts, David Rodbard, William V Tamborlane, John Walsh
This document represents the official position of the American Association of Clinical Endocrinologists and American College of Endocrinology. Where there were no randomized controlled trials or specific U.S. FDA labeling for issues in clinical practice, the participating clinical experts utilized their judgment and experience. Every effort was made to achieve consensus among the committee members. Position statements are meant to provide guidance, but they are not to be considered prescriptive for any individual patient and cannot replace the judgment of a clinician...
February 2016: Endocrine Practice
https://www.readbyqxmd.com/read/26786353/intermedin-adrenomedullin-2-polypeptide-promotes-adipose-tissue-browning-and-reduces-high-fat-diet-induced-obesity-and-insulin-resistance-in-mice
#12
H Zhang, S-Y Zhang, C Jiang, Y Li, G Xu, M-J Xu, X Wang
OBJECTIVES: There is an urgent need to develop interventions and policies to mitigate the health effects of obesity by targeting its metabolic mediators. Adrenomedullin 2 (AM2)/intermedin (IMD) is a secreted peptide that has an important role in protecting the cardiovascular system. However, the role of AM2 in type 2 diabetes is unknown. METHODS: Wild-type (WT) and aP2/AM2 transgenic (aAM2-tg) mice were fed a high-fat diet (HFD) for 8 weeks, and WT mice were treated with AM2 through mini-osmotic pumps...
May 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/25649660/validating-hyperbilirubinemia-and-gut-mucosal-atrophy-with-a-novel-ultramobile-ambulatory-total-parenteral-nutrition-piglet-model
#13
Ajay K Jain, Joy X Wen, Sumit Arora, Keith S Blomenkamp, Jonathan Rodrigues, Timothy A Blaufuss, Victor Liou, Douglas G Burrin, John P Long, Jeffery H Teckman
Total parenteral nutrition (TPN) provides all nutrition intravenously. Although TPN therapy has grown enormously, it causes significant complications, including gut and hepatic dysfunction. Current models use animal tethering which is unlike ambulatory human TPN delivery and is cost prohibitive. We hypothesize that using ultramobile infusion pumps, TPN can be delivered cost-effectively, resulting in classical gut and hepatic injury, and we thus aim to establish a new model system. Neonatal pigs (n=8) were implanted with jugular vein and duodenal catheters...
February 2015: Nutrition Research
https://www.readbyqxmd.com/read/25533134/the-effectiveness-and-risks-of-programming-an-insulin-pump-to-counteract-the-dawn-phenomenon-in-type-1-diabetes
#14
Matthew F Bouchonville, Justin J Jaghab, Elizabeth Duran-Valdez, Ronald M Schrader, David S Schade
OBJECTIVE: Continuous subcutaneous insulin infusion (CSII) programming for an early morning increase in insulin delivery is frequently recommended to counteract the rise in glucose prior to breakfast (dawn phenomenon). However, both the effectiveness and safety of this approach have not been tested in the ambulatory setting. Using continuous glucose monitoring, we investigated the safety and effectiveness of early morning CSII programming for management of the dawn phenomenon in subjects with type 1 diabetes...
December 2014: Endocrine Practice
https://www.readbyqxmd.com/read/25176318/the-effectiveness-of-ambulatory-continuous-peripheral-nerve-blocks-for-postoperative-pain-management-in-children-and-adolescents
#15
Mihaela Visoiu, Lendi N Joy, Jan S Grudziak, Jacques E Chelly
BACKGROUND: Ambulatory continuous peripheral nerve blocks (CPNBs) are feasible for pediatric patients. We sought to evaluate the efficacy of CPNBs in a pediatric population. METHODS: This retrospective report of 33-month prospectively collected data investigates patient, parent, and nurse pain control satisfaction score (PCSS), the incidence and severity of pain, daily analgesic consumption following discharge home with various CPNBs and On-Q pumps, and any complications and side effects related to CPNBs...
November 2014: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/25138273/continuous-transversus-abdominis-plane-tap-blocks-for-postoperative-pain-control-after-hernia-surgery-a-randomized-triple-masked-placebo-controlled-study
#16
RANDOMIZED CONTROLLED TRIAL
Justin W Heil, Ken A Nakanote, Sarah J Madison, Vanessa J Loland, Edward R Mariano, NavParkash S Sandhu, Michael L Bishop, Rishi R Agarwal, James A Proudfoot, Eliza J Ferguson, Anya C Morgan, Brian M Ilfeld
BACKGROUND: Single-injection transversus abdominis plane (TAP) block provides postoperative analgesia and decreases supplemental analgesic requirements. However, there is currently no evidence from randomized, controlled studies investigating the possible benefits of continuous TAP blocks. Therefore, the aim of this randomized, triple-masked, placebo-controlled study was to determine if benefits are afforded by adding a multiple-day, ambulatory, continuous ropivacaine TAP block to a single-injection block following hernia surgery...
November 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/25100389/the-effectiveness-and-risks-of-programming-an-insulin-pump-to-counteract-the-dawn-phenomenon-in-type-1-diabetes
#17
Matthew F Bouchonville, Justin J Jaghab, Elizabeth Duran-Valdez, Ronald M Schrader, David S Schade
Objective: Continuous subcutaneous insulin infusion (CSII) programming for an early morning increase in insulin delivery is frequently recommended to counteract the rise in glucose prior to breakfast (dawn phenomenon). However, both the effectiveness and safety of this approach have not been tested in the ambulatory setting. Using continuous glucose monitoring, we investigated the safety and effectiveness of early morning CSII programming for management of the dawn phenomenon in subjects with type 1 diabetes...
August 6, 2014: Endocrine Practice
https://www.readbyqxmd.com/read/24846358/efficacy-of-cardiac-resynchronisation-therapy-in-the-treatment-of-end-stage-inotrope-dependent-heart-failure-patients
#18
Adam Sokal, Ewa Jędrzejczyk, Radosław Lenarczyk, Sławomir Pluta, Oskar Kowalski, Patrycja Pruszkowska, Michał Mazurek, Andrzej Swiątkowski, Zbigniew Kalarus
BACKGROUND AND AIM: Currently, cardiac resynchronisation therapy (CRT) is recommended only for New York Heart Association (NYHA) class IV ambulatory patients. However, some recent reports have suggested that CRT could also be beneficial for end-stage inotrope-dependent heart failure (HF) NYHA class IV patients. In this report, we summarise the results of CRT implantation in a group of 11 HF inotrope-dependent patients who were not candidates for urgent orthotopic heart transplantation (OHT)...
2014: Kardiologia Polska
https://www.readbyqxmd.com/read/24830997/ashp-national-survey-of-pharmacy-practice-in-hospital-settings-prescribing-and-transcribing-2013
#19
Craig A Pedersen, Philip J Schneider, Douglas J Scheckelhoff
PURPOSE: The results of the 2013 ASHP national survey of pharmacy practice in U.S. hospital settings are presented. METHODS: A stratified random sample of pharmacy directors at 1433 general and children's medical-surgical hospitals was surveyed by mail. IMS Health supplied data on hospital characteristics; the survey sample was drawn from IMS's hospital database. RESULTS: In this national probability sample survey, the response rate was 28...
June 1, 2014: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/24777753/clinical-activity-and-safety-of-the-dual-pathway-inhibitor-rigosertib-for-higher-risk-myelodysplastic-syndromes-following-dna-methyltransferase-inhibitor-therapy
#20
Lewis R Silverman, Peter Greenberg, Azra Raza, Matthew J Olnes, James F Holland, Premkumar Reddy, Manoj Maniar, Francois Wilhelm
Rigosertib (ON 01910.Na) is an inhibitor of the phosphoinositide 3-kinase and polo-like kinase pathways that induces mitotic arrest and apoptosis in neoplastic cells, while sparing normal cells. Our purpose is to summarize the clinical activity and safety of intravenous (IV) rigosertib delivered by an external ambulatory infusion pump in patients with refractory anemia with excess blasts-1, -2, or, -t myelodysplastic syndromes (MDS) following prior treatment with DNA methyltransferase (DNMT) inhibitors. A total of 39 patients with MDS who fulfilled these criteria were enrolled in four phase 1-2 clinical trials of IV rigosertib...
June 2015: Hematological Oncology
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