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https://www.readbyqxmd.com/read/29339177/trends-in-reporting-histological-subtyping-of-renal-cell-carcinoma-association-with-cancer-center-type
#1
Ted Gansler, Stacey Fedewa, Mahul B Amin, Chun Chieh Lin, Ahmedin Jemal
Histological classification of renal cell carcinoma (RCC) has become increasingly important for clinical management. We identified 295,483 RCC diagnosed from 1998-2014 in the National Cancer Database (NCDB) to examine temporal trends in proportions of RCC with unspecified histology and several specific histologies from the 1998 and 2004 World Health Organization classifications of RCC. Further, multivariable log binomial analysis of 101,062 RCC diagnosed from 2010-2014 was used to determine whether the association of diagnosing/treating facility type and the proportion of unspecified RCC is independent of patient demographic and clinical factors...
January 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29330039/age-as-a-prognostic-indicator-for-adjuvant-therapy-in-patients-who-underwent-pancreatic-resections-for-cancer
#2
Alicia Eubanks, Julie Pepe, Paula Veldhuis, Sebastian G de la Fuente
PURPOSE: In pancreatic cancer, the greatest increase in survival is attained by surgical resection followed by adjuvant chemotherapy. Although surgical complications and functional status are recognized as independent factors for halting adjuvant therapy in patients that undergo pancreatic resections, other elements may play a role in deciding which patients get treated postoperatively. Here we determined demographic and clinical characteristics of patients receiving adjuvant chemotherapy, with the primary intent to investigate if age alone affects rates of adjuvant therapy...
January 9, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29327180/chemotherapy-with-or-without-definitive-radiation-therapy-in-inoperable-pancreatic-cancer
#3
Jim Zhong, Jeffrey Switchenko, Madhusmita Behera, David Kooby, Shishir K Maithel, Mark W McDonald, Jolinta Y Lin, Richard J Cassidy, Bassel El-Rayes, Jerome Landry, Pretesh R Patel
BACKGROUND: The LAP07 randomized trial calls into question the role of radiation therapy (RT) in the modern treatment of locally advanced pancreatic cancer (LAPC). However, advances in chemotherapy and RT limit application of the LAP07 results to current clinical practice. Here we utilize the National Cancer Database (NCDB) to evaluate the effects of RT in patients receiving chemotherapy for LAPC. METHODS: Using the NCDB, patients with American Joint Committee on Cancer (AJCC) clinical stage T2-4, N0-1, M0 adenocarcinoma of the pancreas from 2004 to 2014 were analyzed...
January 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29323765/human-papillomavirus-and-nasopharyngeal-cancer
#4
Vivek Verma, Charles B Simone, Chi Lin
BACKGROUND: There are no existing high-volume studies characterizing human papillomavirus (HPV)-associated nasopharyngeal cancer (NPC). METHODS: The National Cancer Data Base (NCDB) was queried for NPC with known HPV (2004-2013). Logistic regression ascertained factors associated with HPV-positivity. Kaplan-Meier overall survival (OS) was evaluated between HPV-positive and HPV-negative cohorts; Cox proportional hazards modeling assessed factors associated with OS...
January 11, 2018: Head & Neck
https://www.readbyqxmd.com/read/29315497/health-care-disparities-among-octogenarians-and-nonagenarians-with-stage-iii-lung-cancer
#5
Richard J Cassidy, Xinyan Zhang, Jeffrey M Switchenko, Pretesh R Patel, Joseph W Shelton, Sibo Tian, Ronica H Nanda, Conor E Steuer, Rathi N Pillai, Taofeek K Owonikoko, Suresh S Ramalingam, Felix G Fernandez, Seth D Force, Theresa W Gillespie, Walter J Curran, Kristin A Higgins
BACKGROUND: To the authors' knowledge, the practice patterns for patients aged more than 80 years with stage III non-small cell lung cancer (NSCLC) is not well known. The purpose of the current study was to investigate factors predictive of and the impact on overall survival (OS) after concurrent chemoradiation (CRT) among patients aged ≥80 years with American Joint Committee on Cancer stage III NSCLC in the National Cancer Data Base (NCDB). METHODS: In the NCDB, patients aged ≥80 years who were diagnosed with stage III NSCLC from 2004 to 2013 with complete treatment records were identified...
January 8, 2018: Cancer
https://www.readbyqxmd.com/read/29314062/postneoadjuvant-adjuvant-chemotherapy-in-resected-n1-non-small-cell-lung-cancer-with-residual-nodal-disease
#6
James W Smithy, Joshua E Rosen, Sarah J Gao, Anthony W Kim
BACKGROUND AND OBJECTIVES: Nodal positivity following neoadjuvant chemotherapy in locally advanced non-small cell lung cancer (NSCLC) is considered a poor prognostic sign, but little data are available on the efficacy of adjuvant chemotherapy in these cases. This analysis sought to determine whether adjuvant chemotherapy was associated with increased survival in NSCLC patients with residual N1 disease at resection. METHODS: Patients from the National Cancer Database (NCDB) with cN1T1-2M0 NSCLC treated with neoadjuvant chemotherapy and definitive resection between 2006 and 2012 were identified...
December 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29309563/neoadjuvant-chemoradiation-radiation-dose-levels-for-surgically-resectable-esophageal-cancer-predictors-of-use-and-outcomes
#7
M Buckstein, R Rhome, M Ru, E Moshier
Neoadjuvant chemoradiation (CRT) followed by surgical resection is the standard of care for resectable, locally advanced esophageal cancer. There are promising results using 41.4 Gy relative to historical controls using higher doses, but the utilization and efficacy of lower neoadjuvant radiation dosing is unclear. This study uses the National Cancer Database (NCDB) to explore patterns of care for neoadjuvant CRT dose levels and outcomes. The NCDB was queried for localized invasive esophageal adenocarcinoma (AC) or squamous cell carcinoma (SCC) receiving neoadjuvant CRT with doses from 40 to 54 Gy followed by surgical resection...
December 22, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29305205/associations-between-travel-distance-hospital-volume-and-outcomes-following-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#8
Leilei Xia, Benjamin L Taylor, Ronac Mamtani, John P Christodouleas, Thomas J Guzzo
OBJECTIVE: To explore the associations between travel distance, hospital volume, and outcomes following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) METHODS: The 2006 to 2013 National Cancer Database (NCDB) was queried to identify patients with MIBC who underwent RC. Multivariable regressions alternately including travel distance, hospital volume, and both in the models were used. Travel distances and hospital volumes were categorized by quartiles. Outcomes of interest were overall survival and quality-of-care indicators...
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29302372/extensive-lymph-node-dissection-improves-survival-among-american-patients-with-gastric-adenocarcinoma-treated-surgically-analysis-of-the-national-cancer-database
#9
Samer A Naffouje, George I Salti
Introduction: The extent of lymphadenectomy in the surgical treatment of gastric cancer is a topic of controversy among surgeons. This study was conducted to analyze the American National Cancer Database (NCDB) and conclude the optimal extent of lymphadenectomy for gastric adenocarcinoma. Methods: The NCDB for gastric cancer was utilized. Patients who received at least a partial gastrectomy were included. Patients with metastatic disease, unknown TNM stages, R1/R2 resection, or treated with a palliative intent were excluded...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29299360/prognostic-relevance-of-human-papillomavirus-infection-in-anal-squamous-cell-carcinoma-analysis-of-the-national-cancer-data-base
#10
Jaymin Jhaveri, Lael Rayfield, Yuan Liu, Mudit Chowdhary, Richard J Cassidy, Nicholas A Madden, Daniel G Tanenbaum, Theresa W Gillespie, Pretesh R Patel, Kirtesh R Patel, Jerome C Landry
Background: To examine the prognostic relevance of human papillomavirus (HPV) infection for anal squamous cell carcinoma (ASCC) patients treated with chemoradiation (CRT) in the National Cancer Data Base (NCDB). Methods: The 2014 NCDB was queried for non-metastatic, histologically confirmed, ASCC patients diagnosed between 2004 and 2013. Patients were required to have HPV status documented in order to be eligible. Patients were then stratified into two groups: HPV+ and HPV-...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29299354/post-operative-radiotherapy-is-associated-with-improved-survival-in-esophageal-cancer-with-positive-surgical-margins
#11
Sarah J Gao, Henry S Park, Christopher D Corso, Charles E Rutter, Sajid A Khan, Kimberly L Johung
Background: The optimal treatment for early-stage esophageal cancer with positive surgical margins after an upfront esophagectomy is not well-defined. This study investigates the effect of post-operative radiotherapy (PORT) on overall survival (OS) in clinical stage I-II patients with positive margins. Methods: We identified patients diagnosed between 2004 and 2012 with clinical stage I-II esophageal carcinoma from the National Cancer Data Base (NCDB) who underwent an upfront esophagectomy...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29286183/leiomyosarcoma-of-the-head-and-neck-a-17-year-single-institution-experience-and-review-of-the-national-cancer-data-base
#12
Alan D Workman, Douglas R Farquhar, Robert M Brody, Arjun K Parasher, Ryan M Carey, Michael T Purkey, Danish A Nagda, John S Brooks, Lee P Hartner, Jason A Brant, Jason G Newman
BACKGROUND: Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single-institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB). METHODS: Patients with head and neck leiomyosarcoma at the University of Pennsylvania and in the NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, and outcomes were evaluated for prognostic significance...
December 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/29273875/robotic-total-pancreatectomy-with-splenectomy-technique-and-outcomes
#13
Ioannis T Konstantinidis, Zeljka Jutric, Oliver S Eng, Susanne G Warner, Laleh G Melstrom, Yuman Fong, Byrne Lee, Gagandeep Singh
BACKGROUND: Robotic total pancreatectomy (TP) represents a minimally invasive approach to a major intra-abdominal operation. Its utility, technique, and outcomes are evolving. METHODS: In this video, we describe a systematic approach to a robotic total pancreatectomy performed for multifocal intraductal papillary mucinous neoplasm (IPMN). Additionally, we reviewed the National Cancer Database (NCDB) to examine the outcomes of robotic TP compared to laparoscopic and open TP between 2010 and 2014...
December 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29248557/differences-in-survival-by-receipt-of-lymph-node-dissection-in-patients-with-invasive-penile-cancer-results-from-the-national-cancer-database
#14
Andres F Correa, Elizabeth Handorf, Shreyas S Joshi, Daniel M Geynisman, Alexander Kutikov, David Y Chen, Robert G Uzzo, Rosalia Viterbo, Richard E Greenberg, Marc C Smaldone
BACKGROUND: Inguinal lymphadenectomy (I-LND) remains underutilized in patients with invasive penile cancer. Using a large national cancer registry, we assessed temporal trends in I-LND utilization and evaluated the impact of I-LND on the survival in patients in whom I-LND is an absolute indication per NCCN guidelines (T1b-4 N0/x-1). METHODS: The National Cancer Database (NCDB) was queried for all non-metastatic penile patients with T1b-4 N0/X-N1 squamous cell carcinoma of the penis from 2004-2014...
December 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29226744/the-role-of-adjuvant-chemotherapy-in-locally-advanced-bladder-cancer
#15
Waqar Haque, Gary D Lewis, Vivek Verma, Jorge G Darcourt, E Brian Butler, Bin S Teh
PURPOSE: The standard of care for locally advanced bladder cancer (LABC) is neoadjuvant chemotherapy followed by cystectomy. However, the role of adjuvant therapy is unclear. The purpose of this study was to evaluate the outcomes of adjuvant chemotherapy for patients with LABC following neoadjuvant chemotherapy and cystectomy, and to determine whether select patients may benefit from adjuvant chemotherapy. METHODS: The National Cancer Data Base (NCDB) was queried (2004-2013) for patients with newly diagnosed pT3-4N0-3M0 bladder cancer that received neoadjuvant chemotherapy and cystectomy...
December 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29223987/radiosurgery-for-brain-metastases-changing-practice-patterns-and-disparities-in-the-united-states
#16
Benjamin H Kann, Henry S Park, Skyler B Johnson, Veronica L Chiang, James B Yu
Background: Management of brain metastases typically includes radiotherapy (RT) with conventional fractionation and/or stereotactic radiosurgery (SRS). However, optimal indications and practice patterns for SRS remain unclear. We sought to evaluate national practice patterns for patients with metastatic disease receiving brain RT. Methods: We queried the National Cancer Data Base (NCDB) for patients diagnosed with metastatic non-small cell lung cancer, breast cancer, colorectal cancer, or melanoma from 2004 to 2014 who received upfront brain RT...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29211849/predictors-of-trimodality-therapy-and-trends-in-therapy-for-malignant-pleural-mesothelioma
#17
David B Nelson, David C Rice, Jiangong Niu, Scott M Atay, Ara A Vaporciyan, Mara B Antonoff, Wayne L Hofstetter, Garrett L Walsh, Stephen G Swisher, Jack A Roth, Anne S Tsao, Daniel R Gomez, Sharon H Giordano, Reza J Mehran, Boris Sepesi
OBJECTIVES: Malignant pleural mesothelioma is an aggressive and rare malignancy that frequently recurs despite aggressive therapy. We evaluated the frequency of treatment with surgery, radiation or chemotherapy, changes in therapy and survival over time and factors associated with the receipt of trimodality therapy. METHODS: The National Cancer Database (NCDB) was used to query patients with histologically proven malignant pleural mesothelioma (2004-14). Treatment over time was evaluated using the Armitage trend test...
December 2, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29198492/adequate-lymph-node-evaluation-in-the-elderly-is-associated-with-improved-survival-in-patients-with-stage-i-iii-colon-cancer-a-validation-study-using-the-national-cancer-data-base
#18
Jeffrey Reha, Shiva Kumar Reddy Mukkamalla, Ritesh Rathore, Ponnandai Sadasivan Somasundar
BACKGROUND: Lymph node involvement (LNI) is an important prognostic factor in colon cancer. But, variations in LNI among different age groups are less known. Adequate lymph node evaluation (LNE) requires assessment of ≥12 nodes. In our previous study, using Surveillance, Epidemiology and End Results (SEER) data, we demonstrated that older patients are less likely to have LNI (Khan et al. 2014). Our current study validates those findings using National Cancer Data Base (NCDB). METHODS: NCDB was queried for patients diagnosed with stages I-III colon adenocarcinoma from 2004 to 2008 who underwent surgical resections...
November 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29193098/factors-associated-with-a-primary-surgical-approach-for-sinonasal-squamous-cell-carcinoma
#19
Jennifer R Cracchiolo, Krupa Patel, Jocelyn C Migliacci, Luc T Morris, Ian Ganly, Benjamin R Roman, Sean M McBride, Viviane S Tabar, Marc A Cohen
BACKGROUND AND OBJECTIVES: Primary surgery is the preferred treatment of T1-T4a sinonasal squamous cell carcinoma (SNSCC). METHODS: Patients with SNSCC in the National Cancer Data Base (NCDB) were analyzed. Factors that contributed to selecting primary surgical treatment were examined. Overall survival (OS) in surgical patients was analyzed. RESULTS: Four-thousand seven hundred and seventy patients with SNSCC were included. In T1-T4a tumors, lymph node metastases, maxillary sinus location, and treatment at high-volume centers were associated with selecting primary surgery...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29188742/management-of-pathologic-node-positive-disease-following-initial-surgery-for-clinical-t1-2-n0-esophageal-cancer-patterns-of-care-and-outcomes-from-the-national-cancer-data-base
#20
Waqar Haque, Vivek Verma, Eric Bernicker, E Brian Butler, Bin S Teh
PURPOSE: Although clinical T1-2N0 esophageal cancer (EC) is often initially surgically resected (without neoadjuvant therapy), several studies have illustrated substantial rates of discovering pathologically node-positive disease. This study evaluated national practice patterns of adjuvant therapy for this population. METHODS: The National Cancer Database (NCDB) was queried (2004-2013) for patients with cT1-2N0M0 EC that received up-front surgery (esophagectomy/local techniques) with subsequent discovery of nodal metastasis...
November 30, 2017: Acta Oncologica
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