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https://www.readbyqxmd.com/read/29144811/concordance-of-preoperative-clinical-stage-with-pathological-stage-in-patients-%C3%A2-45-years-with-well-differentiated-thyroid-cancer
#1
Natalie A Calcatera, Waseem Lutfi, Paritosh Suman, Nicholas R Suss, Chi-Hsiung Wang, Richard A Prinz, David J Winchester, Tricia A Moo-Young
OBJECTIVE: Clinical stage (cStage) in thyroid cancer determines extent of surgical therapy and completeness of resection. Pathologic stage (pStage) is an important determinant of outcome. The rate of discordance between clinical and pathologic stage in thyroid cancer is unknown. METHODS: The National Cancer Data Base (NCDB) was queried to identify 27,473 patients ≥45 years old with cStage I through IV differentiated thyroid cancer undergoing surgery from 2008-2012...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29133167/patterns-of-lymph-node-sampling-and-the-impact-of-lymph-node-density-in-favorable-histology-wilms-tumor-an-analysis-of-the-national-cancer-database
#2
A F Saltzman, A Carrasco, A Amini, J H Aldrink, R Dasgupta, K W Gow, R D Glick, P F Ehrlich, N G Cost
INTRODUCTION: There is controversy about the role of lymph node (LN) sampling or dissection in the management of favorable histology (FH) Wilms tumor (WT), specifically how it performed and how it may impact survival. OBJECTIVE: The objective of this study was to analyze factors affecting LN sampling patterns and the impact of LN yield and density (number of positive LNs/LNs examined) on overall survival (OS) in patients with advanced-stage favorable histology Wilms tumor (FHWT)...
October 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29127538/the-shifting-paradigm-for-breast-cancer-surgery-in-patients-undergoing-neoadjuvant-chemotherapy
#3
Olga Kantor, Gaurav Ajmani, Chi-Hsiung Wang, Avisek Datta, Katharine Yao
INTRODUCTION: Surgical therapy for newly diagnosed breast cancer has changed over the past decade, but these trends have not been well documented in patients undergoing neoadjuvant therapy (NAC). METHODS: In a retrospective cohort study of the National Cancer Database (NCDB), we selected 285,514 women with clinical stage I-III breast cancer who underwent NAC or adjuvant therapy (AC) from 2006 to 2014. Breast-conserving surgery (BCS), unilateral mastectomy (UM), and bilateral mastectomy (BM) rates were compared between patients undergoing NAC and AC...
November 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29123457/survival-benefit-of-postoperative-radiation-in-papillary-meningioma-analysis-of-the-national-cancer-data-base
#4
Whitney A Sumner, Arya Amini, Todd C Hankinson, Nicholas K Foreman, Laurie E Gaspar, Brian D Kavanagh, Sana D Karam, Chad G Rusthoven, Arthur K Liu
Aim/Background: Papillary meningioma represents a rare subset of World Health Organization (WHO) Grade III meningioma that portends an overall poor prognosis. There is relatively limited data regarding the benefit of postoperative radiation therapy (PORT). We used the National Cancer Data Base (NCDB) to compare overall survival (OS) outcomes of surgically resected papillary meningioma cases undergoing PORT compared to post-operative observation. Materials and methods: The NCDB was queried for patients with papillary meningioma, diagnosed between 2004 and 2013, who underwent upfront surgery with or without PORT...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29113653/trends-in-adherence-to-nccn-guidelines-for-breast-conserving-therapy-in-women-with-stage-i-and-ii-breast-cancer-analysis-of-the-1998-2008-national-cancer-data-base
#5
Jilma L Patrick, Michelle E Hasse, Joe Feinglass, Seema A Khan
OBJECTIVE: To examine temporal trends in guideline adherence for breast cancer local therapy, by race/ethnicity, socioeconomic and insurance status. BACKGROUND: Treatment guidelines recommend breast conserving therapy (BCT) for women with small cancers, but have been unevenly applied. A better understanding of time-trends in guideline adherence may point to interventions for correction. METHODS: Patients with tumors ≤2 cm (n = 1,081,075) were identified from 1123 NCDB hospitals, dividing the interval 1998-2011 into 5 segments...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29112483/clinicopathologic-factors-predictive-of-occult-lymph-node-involvement-in-cutaneous-head-and-neck-melanoma
#6
Pratyusha Yalamanchi, Jason A Brant, Jinbo Chen, Jason G Newman
Objectives Evaluate clinicopathologic factors contributing to regional lymph node (LN) metastases in cutaneous head and neck melanoma (HNM). Study Design Retrospective review of a national cancer database. Setting National Cancer Database (2004-2012). Methods National Cancer Database (NCDB) cases diagnosed between 2004 and 2012 were reviewed. Inclusion criteria were head and neck cutaneous site codes, melanoma histology codes, and clinically node-negative status. Independent, clinicopathologic factors associated with pathologic positive LN status were identified by multivariable logistic regression...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29112227/trends-and-variations-in-postmastectomy-radiation-therapy-for-breast-cancer-in-patients-with-1-to-3-positive-lymph-nodes-a-national-cancer-data-base-analysis
#7
Nisha Ohri, Mark P Sittig, Chiaojung Jillian Tsai, Eun-Sil Shelley Hwang, Elizabeth Ann Mittendorf, Weiji Shi, Zhigang Zhang, Alice Y Ho
BACKGROUND: High-level evidence is lacking to guide treatment decisions about postmastectomy radiation therapy (PMRT) in patients who have breast cancer with 1 to 3 positive lymph nodes who receive contemporary systemic therapies, leading to potential variations in PMRT delivery. The objective of this study was to examine nationwide trends in PMRT use in this group. METHODS: The National Cancer Data Base (NCDB) was used to identify 93,372 women who had T1-T2N1 breast cancer diagnosed between 2003 and 2012...
November 7, 2017: Cancer
https://www.readbyqxmd.com/read/29103745/assessment-of-adjuvant-therapy-in-resected-head-and-neck-cancer-with-high-risk-features
#8
Gaurav S Ajmani, Cheryl C Nocon, Chi-Hsiung Wang, Mihir K Bhayani
OBJECTIVES: Subgroup analysis from two randomized trials showed a survival benefit for adjuvant chemoradiation (CRT) over radiation alone (RT) in patients with extracapsular spread (ECS) of involved lymph nodes and/or positive margins (PM) in resected head and neck cancer (HNSCC). However, results were not analyzed separately for patients with ECS or PM and were not stratified by tumor subsite/HPV status. We therefore sought to determine whether adjuvant CRT is associated with a survival benefit, separately among patients with ECS or PM and stratified by subsite/HPV status...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29091535/survival-as-a-quality-metric-of-cancer-care-use-of-the-national-cancer-data-base-to-assess-hospital-performance
#9
Lawrence N Shulman, Bryan E Palis, Ryan McCabe, Kathy Mallin, Ashley Loomis, David Winchester, Daniel McKellar
PURPOSE: Survival is considered an important indicator of the quality of cancer care, but the validity of different methodologies to measure comparative survival rates is less well understood. We explored whether the National Cancer Data Base (NCDB) could serve as a source of unadjusted and risk-adjusted cancer survival data and whether these data could be used as quality indicators for individual hospitals or in the aggregate by hospital type. METHODS: The NCDB, an aggregate of > 1,500 hospital cancer registries, was queried to analyze unadjusted and risk-adjusted hazards of death for patients with stage III breast cancer (n = 116,787) and stage IIIB or IV non-small-cell lung cancer (n = 252,392)...
November 1, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29079210/differences-at-presentation-and-treatment-of-testicular-cancer-in-hispanic-men-institutional-and-national-hospital-based-analysis
#10
Solomon L Woldu, Ahmet M Aydin, Ashwin V Rao, Ryan C Hutchinson, Nirmish Singla, Timothy N Clinton, Laura-Maria Krabbe, Niccolo M Passoni, Ganesh V Raj, David S Miller, James F Amatruda, Arthur I Sagalowsky, Yair Lotan, Yull Arriaga, Vitaly Margulis, Aditya Bagrodia
OBJECTIVE: To describe epidemiological patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidly in this demographic, yet little is known about TGCTs in Hispanic patients. MATERIAL AND METHODS: We compared patient factors, tumor characteristics, treatment patterns, and outcomes of non-Hispanic white (NHW) vs...
October 24, 2017: Urology
https://www.readbyqxmd.com/read/29067580/comparison-of-laparoscopic-to-open-pancreaticoduodenectomy-in-elderly-patients-with-pancreatic-adenocarcinoma
#11
Brandon C Chapman, Csaba Gajdos, Patrick Hosokawa, William Henderson, Alessandro Paniccia, Douglas M Overbey, Ana Gleisner, Richard D Schulick, Martin D McCarter, Barish H Edil
INTRODUCTION: The purpose of the study is to compare perioperative and survival outcomes in elderly patients undergoing laparoscopic pancreaticoduodenectomy (LPD) to those undergoing open pancreaticoduodenectomy (OPD). METHODS: Patients aged ≥ 75 years with pancreatic adenocarcinoma undergoing LPD or OPD were identified from the NCDB (2010-2013). Baseline characteristics and perioperative outcomes were compared using a χ (2) and Student's t test. The Kaplan-Meier method was used to generate survival curves, and differences were tested using a log-rank test...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29045018/patient-disease-and-treatment-factors-associated-with-overall-survival-in-esthesioneuroblastoma
#12
Ryan M Carey, Joseph Godovchik, Alan D Workman, Edward C Kuan, Arjun K Parasher, Jinbo Chen, James N Palmer, Nithin D Adappa, Jason G Newman, Jason A Brant
BACKGROUND: Esthesioneuroblastomas (ENB) are uncommon and data regarding outcomes are often limited to single-institution series. The National Cancer Database (NCDB), which contains outcomes information from treatment centers across the United States, represents an opportunity to evaluate outcomes for rare diseases such as ENB across multiple institutions. METHODS: The NCDB was queried for location codes corresponding to the nasal cavity and paranasal sinuses and the histology code for ENB...
October 17, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29043526/chemoradiation-therapy-for-unresected-extrahepatic-cholangiocarcinoma-a-propensity-score-matched-analysis
#13
Anna Torgeson, Shane Lloyd, Dustin Boothe, George Cannon, Ignacio Garrido-Laguna, Jonathan Whisenant, Mark Lewis, Robin Kim, Courtney Scaife, Randa Tao
BACKGROUND: Unresected extrahepatic cholangiocarcinoma (uEHCC) remains a deadly disease. Guidelines for uEHCC recommend either chemotherapy alone (CT) or chemoradiotherapy (CRT). This study used the National Cancer Database (NCDB) to compare outcomes for patients treated with CT and those who underwent CRT. METHODS: Patients with initially diagnosed non-metastatic uEHCC from 2004 to 2014 were identified. Using Chi square analysis, patients who underwent CT were compared with those who received CRT...
October 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28990257/validation-of-the-eighth-edition-american-joint-committee-on-cancer-staging-system-for-human-papillomavirus-associated-oropharyngeal-cancer
#14
John D Cramer, Kate E Hicks, Alfred W Rademaker, Urjeet A Patel, Sandeep Samant
BACKGROUND: The eighth edition American Joint Committee on Cancer (AJCC) staging manual includes major changes in staging of oropharyngeal cancer (OPC). We evaluated the new staging system in order to validate this shift in classification. METHODS: We used the National Cancer Database (NCDB) to identify patients with human papillomavirus-associated (HPV-positive) OPC from 2010-2013. We restaged patients using the eighth edition guidelines and compared them with those from the seventh edition...
October 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28983555/measuring-institutional-quality-in-head-and-neck-surgery-using-hospital-level-data-negative-margin-rates-and-neck-dissection-yield
#15
David W Schoppy, Kim F Rhoads, Yifei Ma, Michelle M Chen, Brian Nussenbaum, Ryan K Orosco, Eben L Rosenthal, Vasu Divi
Importance: Negative margins and lymph node yields (LNY) of 18 or more from neck dissections in patients with head and neck squamous cell carcinomas (HNSCC) have been associated with improved patient survival. It is unclear whether these metrics can be used to identify hospitals with improved outcomes. Objective: To determine whether 2 patient-level metrics would predict outcomes at the hospital level. Design, Setting, and Participants: A retrospective review of records from the National Cancer Database (NCDB) was used to identify patients who underwent primary surgery and concurrent neck dissection for HNSCC between 2004 and 2013...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28982876/radical-cystectomy-versus-chemoradiation-for-muscle-invasive-bladder-cancer-impact-of-treatment-facility-and-sociodemographics
#16
COMPARATIVE STUDY
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
BACKGROUND: The present study sought to compare the differences in practice patterns, as well as clinical outcomes for patients with muscle-invasive bladder cancer undergoing treatment with either radical cystectomy (RC) or concurrent chemoradiaiton (CRT). PATIENTS AND METHODS: The National Cancer Data Base (NCDB) was queried for patients diagnosed with T2/T3/T4aN0M0 bladder cancer, between 2004-2013, that received definitive treatment with either RC or CRT. RESULTS: 16,960 patients met the inclusion criteria; 1,450 (8...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28980424/development-and-validation-of-a-nomogram-predicting-the-overall-survival-of-stage-iv-breast-cancer-patients
#17
Shunrong Li, Jianli Zhao, Liling Zhu, Fengxi Su, Kai Chen
This study aimed to develop a nomogram to predict the overall survival (OS) of stage IV breast cancer patients. We searched the National Cancer Database (NCDB) for stage IV breast cancer patients diagnosed between 2010 and 2013. Predictors of OS were identified and a nomogram was developed and validated using concordance index (C-index), calibration plots, and risk group stratifications. A total of 7199 patients from the NCDB were included in the study. With a median follow-up of 25.7 months, the 1-year and 3-year OS rates were 80...
November 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28980407/social-determinants-of-stage-iv-anal-cancer-and-the-impact-of-pelvic-radiotherapy-in-the-metastatic-setting
#18
Michael C Repka, Nima Aghdam, Andrew W Karlin, Keith R Unger
Anal cancer is a relatively rare malignancy, and a minority of patients present with metastatic disease in the United States. The National Cancer Database (NCDB) was used to identify factors associated with metastatic disease at presentation and evaluate the role of pelvic radiotherapy in these patients. The NCDB was queried for patients with squamous cell cancer of the anus diagnosed between 2004 and 2013. Patients were stratified by clinical stage at diagnosis, and a binary logistic regression model was created to identify factors associated with metastatic disease at diagnosis...
November 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28977996/evaluation-of-the-7-th-and-8-th-editions-of-the-ajcc-uicc-tnm-staging-systems-for-lung-cancer-in-a-large-north-american-cohort
#19
Lin Yang, Shidan Wang, Yunyun Zhou, Sunny Lai, Guanghua Xiao, Adi Gazdar, Yang Xie
PURPOSE: The new 8(th) American Joint Committee on Cancer (AJCC)/International Union for Cancer Control (UICC) lung cancer staging system was developed and internally validated using the International Association for the Study of Lung Cancer (IASLC) database, but external validation is needed. The goal of this study is to validate the discriminatory ability and prognostic performance of this new staging system in a larger, independent non-small cell lung cancer (NSCLC) cohort with greater emphasis on North American patients...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28963794/surrogate-for-oropharyngeal-cancer-hpv-status-in-cancer-database-studies
#20
Uchechukwu C Megwalu, Michelle M Chen, Yifei Ma, Vasu Divi
BACKGROUND: The utility of cancer databases for oropharyngeal cancer studies is limited by lack of information on human papillomavirus (HPV) status. The purpose of this study was to develop a surrogate that can be used to adjust for the effect of HPV status on survival. METHODS: The study cohort included 6419 patients diagnosed with oropharyngeal squamous cell carcinoma between 2004 and 2012, identified in the National Cancer Database (NCDB). The HPV surrogate score was developed using a logistic regression model predicting HPV-positive status...
September 30, 2017: Head & Neck
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