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https://www.readbyqxmd.com/read/27899201/revisiting-milan-cervical-cancer-study-do-the-original-findings-hold-in-the-era-of-chemotherapy
#1
W Ross Green, Lara Hathout, Atif J Khan, Mohamed A Elshaikh, Sushil Beriwal, William Small, Omar Mahmoud
BACKGROUND: The primary treatment of early stage cervical carcinoma (IB-IIA) is either surgery or radiation therapy based on the pivotal Milan randomized study published twenty years ago. In the presence of high-risk features, the gold standard treatment is concurrent chemotherapy and radiation therapy (CRT) whether it is the in the postoperative or the definitive setting. Using the National Cancer Data Base (NCDB), the goal of our study is to compare the outcomes of surgery and radiation therapy in the chemotherapy era...
November 26, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27893532/the-effect-of-hospital-volume-on-breast-cancer-mortality
#2
Rachel A Greenup, Samilia Obeng-Gyasi, Samantha Thomas, K Houck, Whitney O Lane, Rachel C Blitzblau, Terry Hyslop, E Shelley Hwang
OBJECTIVE: The aim of this study was to determine whether hospital volume was associated with mortality in breast cancer, and what thresholds of case volume impacted survival. BACKGROUND: Prior literature has demonstrated improved survival with treatment at high volume centers among less common cancers requiring technically complex surgery. METHODS: All adults (18 to 90 years) with stages 0-III unilateral breast cancer diagnosed from 2004 to 2012 were identified from the American College of Surgeons National Cancer Data Base (NCDB)...
November 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27862623/patterns-of-care-and-survival-outcomes-in-the-treatment-of-esophageal-melanoma
#3
Joseph P Weiner, Meng Shao, David Schwartz, Andrew Wong, David Schreiber
Because of the rarity of esophageal melanoma, the optimal management of this disease is limited. The pooled dataset in the National Cancer Database (NCDB) was used to identify the prognostic factors and treatment outcomes. Patients who were diagnosed with esophageal melanoma between 2004 and 2011 were identified. Patients were stratified as either localized (T1-4N0M0), regional (T1-4N+M0), or metastatic (M1). The primary endpoint of this study was overall survival (OS) which was analyzed using the Kaplan-Meier method and multivariate Cox regression, which was performed to identify potential factors influencing survival...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27860114/treatment-and-survival-outcomes-of-small-cell-carcinoma-of-the-esophagus-an-analysis-of-the-national-cancer-data-base
#4
Andrew T Wong, Meng Shao, Justin Rineer, Virginia Osborn, David Schwartz, David Schreiber
Given the paucity of esophageal small cell carcinoma (SCC) cases, there are few large studies evaluating this disease. In this study, the National Cancer Data Base (NCDB) was utilized to analyze the clinical features, treatment, and survival of patients with esophageal SCC in a large, population-based dataset. We selected patients diagnosed with esophageal SCC from 1998 to 2011. Patients were identified as having no treatment, chemotherapy alone, radiation ± sequential chemotherapy, concurrent chemoradiation, and esophagectomy ± chemotherapy and/or radiation...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27859415/predictors-of-survival-in-posterior-cricoid-squamous-cell-carcinoma-a-study-of-248-cases
#5
Hassieb A Din, Kevin Y Zhan, Caitlin Bolin, Shaun Nguyen, Eric J Lentsch
OBJECTIVES: We aimed to describe the presentation, treatment patterns, and survival characteristics of posterior cricoid squamous cell carcinoma (SCC) with the National Cancer Database (NCDB). STUDY DESIGN: Retrospective database review. METHODS: We reviewed the NCDB from 2004 to 2013. Primary, previously untreated cases of posterior cricoid SCC were studied. Cox regression analysis was performed to look for prognostic factors. RESULTS: Out of 14,416 hypopharyngeal malignancies, 269 (1...
November 9, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27844308/impact-of-concurrent-chemotherapy-with-radiation-therapy-for-elderly-patients-with-newly-diagnosed-glioblastoma-a-review-of-the-national-cancer-data-base
#6
Jiayi Huang, Pamela Samson, Stephanie M Perkins, George Ansstas, Milan G Chheda, Todd A DeWees, Christina I Tsien, Clifford G Robinson, Jian L Campian
To investigate the utilization and overall survival (OS) impact of concurrent chemotherapy in combination with radiation therapy (RT) for elderly glioblastoma (GBM) patients. Elderly patients (age >70) with supratentorial and nonmetastatic GBM who received RT of 20-75 Gy with concurrent single-agent chemotherapy (ChemoRT) or without (RT alone) during 2004-2012 were identified from the National Cancer Data Base (NCDB). The Cochran-Armitage test was used for trend analysis. Hazard ratios (HR) and 95% confidence intervals (CIs) were determined using Cox proportional hazards...
November 14, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27823769/patterns-of-adjuvant-radiation-usage-and-survival-outcomes-for-stage-i-endometrial-carcinoma-in-a-large-hospital-based-cohort
#7
Andrew T Wong, Justin Rineer, David Schwartz, Joseph Weiner, Joseph Safdieh, Kwang Choi, David Schreiber
OBJECTIVE: Two randomized trials have demonstrated a local control advantage in the absence of a survival advantage for the addition of adjuvant radiation therapy (RT) to surgery in patients with stage I endometrial adenocarcinoma (EC). This study analyzed the National Cancer Data Base (NCDB) to evaluate the impact of adjuvant RT on overall survival (OS) for patients with stage I EC. METHODS: Patients with EC who underwent total hysterectomy/bilateral salpingo-oophorectomy between 2004 and 2011 were queried...
November 4, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27799511/high-risk-of-adverse-pathologic-features-in-patients-with-clinical-t1-high-grade-bladder-cancer-undergoing-radical-cystectomy
#8
Richard S Matulewicz, Brendan T Frainey, Daniel T Oberlin, Joshua J Meeks
BACKGROUND: Radical cystectomy (RC) is used to treat select patients with T1 high-grade (T1HG) bladder cancer. However, population-level utilization trends and outcomes for these patients are not well-known. We sought to evaluate treatment patterns and clinicopathologic outcomes of RC for T1HG bladder cancer. PATIENTS AND METHODS: Using the National Cancer Data Base (NCDB) for 1998-2012, we conducted a retrospective cohort study of patients with clinical T1HG bladder cancer...
November 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27793358/adjuvant-radiation-therapy-is-associated-with-improved-overall-survival-in-high-intermediate-risk-stage-i-endometrial-cancer-a-national-cancer-data-base-analysis
#9
Vishal Gupta, Mary McGunigal, Monica Prasad-Hayes, Tamara Kalir, Jerry Liu
PURPOSE: Adjuvant radiation therapy (RT) was shown to improve local control in patients with high-intermediate risk (HIR) stage I endometrial cancer (EC) in randomized trials. Overall survival (OS) was not significantly different with adjuvant RT in these trials or subsequent meta-analyses; however, they were underpowered to assess OS. We used the National Cancer Data Base (NCDB) to examine the impact of adjuvant RT on OS in HIR EC patients. METHODS: The NCDB was queried for patients diagnosed with FIGO (2009) Stage I endometrioid adenocarcinoma from 1998 to 2012 who underwent surgery±adjuvant RT...
October 25, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27780316/can-we-eliminate-neoadjuvant-chemoradiotherapy-in-favor-of-neoadjuvant-multiagent-chemotherapy-for-select-stage-ii-iii-rectal-adenocarcinomas-analysis-of-the-national-cancer-database
#10
Richard J Cassidy, Yuan Liu, Kirtesh Patel, Jim Zhong, Conor E Steuer, David A Kooby, Maria C Russell, Theresa W Gillespie, Jerome C Landry
BACKGROUND: Stage II and III rectal cancers have been effectively treated with neoadjuvant chemoradiotherapy (NCRT) followed by definitive resection. Advancements in surgical technique and systemic therapy have prompted investigation of neoadjuvant multiagent chemotherapy (NMAC) regimens with the elimination of radiation (RT). The objective of the current study was to investigate factors that predict for the use of NCRT versus NMAC and compare outcomes using the National Cancer Data Base (NCDB) for select stage II and III rectal cancers...
October 25, 2016: Cancer
https://www.readbyqxmd.com/read/27771166/survival-of-women-with-mullerian-adenosarcoma-a-national-cancer-data-base-study
#11
Brandon-Luke L Seagle, Margaux Kanis, Anna E Strohl, Shohreh Shahabi
OBJECTIVE: To determine overall survival (OS) and factors associated with OS of women with Mullerian adenosarcoma. METHODS: Women with adenosarcoma of the uterus, cervix or ovary (n=2205) were identified from the 1998-2011 National Cancer Data Base. Kaplan-Meier and multivariate Cox proportional-hazards survival analyses were performed to test for associations of potential explanatory variables with OS. A subset analysis of women with uterine adenosarcoma was also performed...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27765588/increased-use-of-cystectomy-in-patients-75-and-older-a-contemporary-analysis-of-survival-and-perioperative-outcomes-from-the-national-cancer-database
#12
Matthew J Bream, Matthew J Maurice, Joshua Altschuler, Hui Zhu, Robert Abouassaly
OBJECTIVE: To assess national utilization patterns for cystectomy and nonsurgical treatments for elderly patients with muscle-invasive bladder cancer. METHODS: From the National Cancer Database, we identified patients ≥75 years old with T2-T4, non-metastatic urothelial carcinoma between 2003 and 2012. Patients were grouped by treatment: cystectomy, chemoradiation, or nonstandard treatment. Cochran-Armitage trend test was used to evaluate time trends for treatments and perioperative outcomes...
October 17, 2016: Urology
https://www.readbyqxmd.com/read/27746190/role-of-postoperative-radiotherapy-in-pathologic-stage-iiia-n2-non-small-cell-lung-cancer-in-a-prospective-nationwide-oncology-outcomes-database
#13
Alex Herskovic, Elizabeth Mauer, Paul Christos, Himanshu Nagar
BACKGROUND: The role of postoperative radiotherapy (PORT) in the treatment of pathologic stage IIIA (N2) non-small cell lung cancer (NSCLC) remains controversial. We investigated practice patterns and outcomes for these patients in a prospectively maintained nationwide oncology outcomes database. METHODS: Patients with known histologies of pathologic stage IIIA (N2) NSCLC who underwent surgery with negative margins and received adjuvant multiagent chemotherapy from 2004-2013 were identified from the National Cancer DataBase (NCDB) and stratified by the use of PORT...
October 13, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27720827/timing-of-surgery-after-neoadjuvant-chemoradiation-in-locally-advanced-non-small-cell-lung-cancer
#14
Sarah J Gao, Christopher D Corso, Elyn H Wang, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: A subset of patients with potentially resectable clinical stage IIIA non-small cell lung cancer (NSCLC) are managed with trimodality therapy. However, little data exist to guide the timing of surgery after neoadjuvant therapy. This study examined whether the time interval between neoadjuvant chemoradiation (NCRT) and surgical resection impacts overall survival. METHODS: Clinical stage IIIA disease (T1-3 N2) NSCLC patients who underwent neoadjuvant chemoradiation therapy were identified in the National Cancer Data Base (NCDB) between 2004-2012 and categorized based on the interval between chemoradiation and surgery (0 to ≤3, 3 to ≤6, 6 to ≤9, and 9 to ≤12 weeks)...
October 5, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27720774/outcomes-and-prognostic-factors-of-primary-urethral-cancer
#15
Wilson Sui, Arindam RoyChoudry, Sven Wenske, Guarionex J Decastro, James M McKiernan, Christopher B Anderson
OBJECTIVE: To identify prognostic and treatment factors for primary urethral cancer using a nationwide database. MATERIALS AND METHODS: The National Cancer Database (NCDB) was queried for all cases of primary urethral cancer from 2004-2013. Patients with other cancer diagnoses, metastasis or diagnosis on autopsy we excluded. Proportional hazards regression was used to identify independent predictors of overall survival in patients with primary urethral cancer. Because we hypothesized that predictors may covary by sex, we also performed regression analysis stratified by sex...
October 5, 2016: Urology
https://www.readbyqxmd.com/read/27717204/treatment-modalities-in-sinonasal-undifferentiated-carcinoma-an-analysis-from-the-national-cancer-database
#16
Mohemmed N Khan, Neeraja Konuthula, Arjun Parasher, Eric M Genden, Brett A Miles, Satish Govindaraj, Alfred M Iloreta
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy of unknown etiology with a poor overall prognosis. Its relative rarity has made it difficult to determine the impact of different treatment modalities on survival. METHODS: Retrospective study of cases in the National Cancer Data Base (NCDB). NCDB cases that were diagnosed as having SNUC between January 1, 2004, and December 31, 2013 were included in the analysis. Outcomes of patients treated with surgery followed adjuvant chemoradiotherapy were compared with definitive chemoradiotherapy...
October 7, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27692833/risk-of-lymph-node-metastases-in-pathological-gleason-score%C3%A2-6-prostate-adenocarcinoma-analysis-of-institutional-and-population-based-databases
#17
Hannah Wenger, Adam B Weiner, Aria Razmaria, Gladell P Paner, Scott E Eggener
INTRODUCTION: Several institutional studies have suggested that pathological Gleason score≤6 prostate cancer has little or no capacity for metastasis. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database (SEER, 2004-2011, n = 19,594) and the National Cancer Database (NCDB, 2004-2013, n = 57,540), we identified patients with pathological Gleason score≤6 prostate cancer following radical prostatectomy and lymph node dissection...
September 27, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27686970/effect-of-thoracic-radiotherapy-timing-and-fractionation-on-survival-in-nonmetastatic-small-cell-lung-carcinoma
#18
Andrew T Wong, Justin Rineer, David Schwartz, Daniel Becker, Joseph Safdieh, Virginia Osborn, David Schreiber
BACKGROUND: The optimal timing of thoracic radiation therapy (RT) in relation to chemotherapy is unknown in the treatment of nonmetastatic small cell lung cancer (SCLC). We analyzed the National Cancer Data Base (NCDB) to assess the effect on overall survival (OS) of RT timing with chemotherapy for patients with SCLC. MATERIALS AND METHODS: The NCDB was queried for patients diagnosed with nonmetastatic SCLC from 1998 to 2011 who had undergone definitive chemoradiation...
August 8, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27675761/radiation-for-pancreatic-adenocarcinoma-an-end-of-life-treatment-assessing-appropriate-radiation-therapy-utilization-in-the-national-cancer-data-base-ncdb
#19
L E Colbert, K V Dharmarajan, J Switchenko, C M Taniguchi, W A Hall, T W Gillespie, D A Kooby, J Lipscomb, J C Landry
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675751/impact-of-radiation-dose-escalation-for-cervical-esophageal-cancer-a-national-cancer-data-base-ncdb-analysis
#20
B De, R Rhome, M Buckstein
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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