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https://www.readbyqxmd.com/read/28241198/using-the-national-cancer-database-for-outcomes-research-a-review
#1
Daniel J Boffa, Joshua E Rosen, Katherine Mallin, Ashley Loomis, Greer Gay, Bryan Palis, Kathleen Thoburn, Donna Gress, Daniel P McKellar, Lawrence N Shulman, Matthew A Facktor, David P Winchester
Importance: The National Cancer Database (NCDB), a joint quality improvement initiative of the American College of Surgeons Commission on Cancer and the American Cancer Society, has created a shared research file that has changed the study of cancer care in the United States. A thorough understanding of the nuances, strengths, and limitations of the database by both readers and investigators is of critical importance. This review describes the use of the NCDB to study cancer care, with a focus on the advantages of using the database and important considerations that affect the interpretation of NCDB studies...
February 23, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28236349/treatment-delays-in-oral-cavity-squamous-cell-carcinoma-and-association-with-survival
#2
Rance J T Fujiwara, Benjamin L Judson, Wendell G Yarbrough, Zain Husain, Saral Mehra
BACKGROUND: Treatment durations and factors associated with delays for oral cavity squamous cell carcinoma (SCC) have previously been described but are not fully understood. Impact of delays on overall survival (OS) remains unclear. METHODS: The National Cancer Data Base (NCDB) was used to analyze 4868 patients with oral cavity SCC from 1998 to 2011. Diagnosis-to-surgery, surgery-to-radiotherapy (RT)start , RT duration, total treatment package (surgery-to-RTend ), and diagnosis-to-RTend were evaluated...
February 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28214574/minimally-invasive-versus-open-approach-for-cystectomy-trends-in-the-utilization-and-demographic-or-clinical-predictors-using-the-national-cancer-database-ncdb
#3
Andrew G Bachman, Alexander A Parker, Marshall D Shaw, Brian W Cross, Kelly L Stratton, Michael S Cookson, Sanjay G Patel
OBJECTIVES: To examine temporal national trends of operative approach for cystectomy and identify demographic or clinical predictive factors that influence choice of approach. METHODS: We performed a retrospective cohort study of patients who underwent cystectomy for bladder cancer between 2010 and 2013 using the National Cancer Database (NCDB). Approach was stratified by open vs. minimally invasive (robotic or laparoscopic). Univariate Pearson chi-square and multivariate logistic regression analysis was used to assess relationships between demographic and hospital factors and the receipt of minimally invasive or open surgical approach...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28209069/patterns-of-care-and-survival-outcomes-of-palliative-radiation-for-prostate-cancer-with-bone-metastases-comparison-of-%C3%A2-5-fractions-to-%C3%A2-10-fractions
#4
David Schreiber, Joseph Safdieh, Daniel J Becker, David Schwartz
BACKGROUND: To review the palliative radiation fractionation regimens, trends and survival of men within the National Cancer Database (NCDB) diagnosed with prostate cancer and bony metastases. METHODS: A total of 3,871 patients from the NCDB were included in the analysis (patients treated from 2004-2012). The following fractionation regimens were analyzed [8 Gy × 1, 4 Gy × 5 (short course radiation therapy)], were compared to 3 Gy × 10, 2.50 Gy × 14-15 and 2 Gy × 20-30 (long course radiation therapy)...
January 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28194862/patterns-of-care-and-survival-of-adjuvant-radiation-for-major-salivary-adenoid-cystic-carcinoma
#5
Anna Lee, Babak Givi, Virginia W Osborn, David Schwartz, David Schreiber
OBJECTIVES/HYPOTHESIS: National Cancer Care Network guidelines suggest consideration of adjuvant radiation even for early stage adenoid cystic carcinoma of the salivary glands. We used the National Cancer Data Base (NCDB) to analyze practice patterns and outcomes of postoperative radiotherapy for adenoid cystic carcinomas. STUDY DESIGN: Retrospective NCDB review. METHODS: Patients with nonmetastatic adenoid cystic carcinoma of the parotid, submandibular, or another major salivary gland from 2004 to 2012 were identified...
February 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28193571/outcomes-and-utilization-of-postmastectomy-radiotherapy-for-t3n0-breast-cancers
#6
Samual R Francis, Jonathan Frandsen, Kristine E Kokeny, David K Gaffney, Matthew M Poppe
BACKGROUND: The role of postmastectomy radiotherapy (PMRT) for women with pT3N0M0 breast cancer is controversial. We sought to determine the benefit of PMRT in this cohort using the National Cancer Database (NCDB). METHODS: We analyzed women with pT3N0M0 breast cancer who received mastectomy with or without PMRT between 2004 and 2012. We excluded men, women ≤18 years, neoadjuvant or unknown radiation or chemotherapy status, unknown estrogen or progesterone receptor status, unknown surgical margin status, histology other than invasive ductal or lobular carcinoma, and if death occurred <3 months after diagnosis...
February 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28192632/assessing-the-relative-influence-of-hospital-and-surgeon-volume-on-short-term-mortality-following-radical-cystectomy
#7
Nikhil Waingankar, Katherine Mallin, Marc Smaldone, Brian L Egleston, Andrew Higgins, David P Winchester, Robert Uzzo, Alexander Kutikov
OBJECTIVES: To assess the relationship between surgeon and hospital volume on mortality following radical cystectomy (RC). PATIENTS AND METHODS: We queried the National Cancer Database (NCDB) for adult patients undergoing RC from 2010-2013. We calculated average volume for each surgeon (SV) and hospital (HV). Using propensity-scored weights for combined volume groups with a proportional hazards regression model, we compared association between HV and SV on 90-day survival following RC...
February 13, 2017: BJU International
https://www.readbyqxmd.com/read/28187056/operative-mortality-rates-of-acoustic-neuroma-surgery-a-national-cancer-database-analysis
#8
Shearwood McClelland, Ellen Kim, James D Murphy, Jerry J Jaboin
INTRODUCTION: Optimal acoustic neuroma (AN) management involves choosing between three treatment modalities: microsurgical excision, radiation, or observation with serial imaging. The reported in-hospital mortality rate of surgery for AN in the United States is 0.5%. However, there has yet to be a nationwide examination of the AN surgery mortality rate encompassing the period beyond initial hospital discharge. METHODS: The National Cancer Data Base (NCDB) from 2004 to 2013 identified AN patients receiving surgery...
February 9, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28173790/dcis-and-axillary-nodal-evaluation-compliance-with-national-guidelines
#9
Katrina B Mitchell, Heather Lin, Yu Shen, Alfred Colfry, Henry Kuerer, Simona F Shaitelman, Gildy V Babiera, Isabelle Bedrosian
BACKGROUND: The National Comprehensive Cancer Network (NCCN) and the American Society of Clinical Oncology (ASCO) provide guidelines regarding axillary nodal evaluation in ductal carcinoma in situ (DCIS), but data regarding national compliance with these guidelines remains incomplete. METHODS: We conducted a retrospective review of the National Cancer Data Base (NCDB) analyzing all surgical approaches to axillary evaluation in patients with DCIS. Logistic regression analysis was used to assess the multivariate relationship between patient demographics, clinical characteristics, and probability of axillary evaluation...
February 7, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28168388/external-validation-of-a-survival-nomogram-for-non-small-cell-lung-cancer-using-the-national-cancer-database
#10
Katelyn A Young, Enobong Efiong, James T Dove, Joseph A Blansfield, Marie A Hunsinger, Jeffrey L Wild, Mohsen M Shabahang, Matthew A Facktor
PURPOSE: Survival nomograms offer individualized predictions using a more diverse set of factors than traditional staging measures, including the American Joint Committee on Cancer Tumor Node Metastasis (AJCC TNM) Staging System. A nomogram predicting overall survival (OS) for resected, non-metastatic non-small cell lung cancer (NSCLC) has been previously derived from Asian patients. The present study aims to determine the nomogram's predictive capability in the US using the National Cancer Database (NCDB)...
February 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28159409/disparities-in-receipt-of-care-for-high-grade-endometrial-cancer-a-national-cancer-data-base-analysis
#11
Amy J Bregar, J Alejandro Rauh-Hain, Ryan Spencer, Joel T Clemmer, John O Schorge, Laurel W Rice, Marcela G Del Carmen
PURPOSE: To examine patterns of care and survival for Hispanic women compared to white and African American women with high-grade endometrial cancer. METHODS: We utilized the National Cancer Data Base (NCDB) to identify women diagnosed with uterine grade 3 endometrioid adenocarcinoma, carcinosarcoma, clear cell carcinoma and papillary serous carcinoma between 2003 and 2011. The effect of treatment on survival was analyzed using the Kaplan-Meier method. Factors predictive of outcome were compared using the Cox proportional hazards model...
February 1, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28156538/variation-in-utilization-of-palliative-surgery-in-patients-with-metastatic-colorectal-cancer
#12
Hari Nathan, Scott E Regenbogen, Samantha Hendren, Arden M Morris, Pasithorn Amy Suwanabol
: 120 Background: Twenty-five percent of patients with colorectal cancer will present with unresectable disease. Palliative surgery has been shown to improve symptom control and improve patient satisfaction as well as demonstrate improved cost and decreased healthcare utilization. However, it is unclear what factors influence use. We sought to determine patient and hospital factors associated with palliative surgery use in advanced colorectal cancers. METHODS: Using the National Cancer Data Base (NCDB) Participant User File from 2006 to 2012, 162,967 patients with metastatic colorectal cancer were identified...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154950/radiation-therapy-is-independently-associated-with-worse-survival-after-r0-resection-for-stage-i-ii-non-small-cell-lung-cancer-an-analysis-of-the-national-cancer-data-base
#13
Todd A Pezzi, Abdallah S R Mohamed, Clifton D Fuller, Pierre Blanchard, Christopher Pezzi, Boris Sepesi, Stephen M Hahn, Daniel R Gomez, Stephen G Chun
BACKGROUND: The 1998 post-operative radiotherapy meta-analysis for lung cancer showed a survival detriment associated with radiation for stage I-II resected non-small cell lung cancer (NSCLC), but has been criticized for including antiquated radiation techniques. We analyzed the National Cancer Database (NCDB) to determine the impact of radiation after margin-negative (R0) resection for stage I-II NSCLC on survival. METHODS: Adult patients from 2004 to 2014 were analyzed from the NCDB with respect to receiving radiation as part of their first course of treatment for resected stage I-II NSCLC; the primary outcome measure was overall survival...
February 2, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28153774/patterns-of-care-and-survival-outcomes-for-adolescent-and-young-adult-patients-with-testicular-seminoma-in-the-united-states-a-national-cancer-database-analysis
#14
William Stokes, Arya Amini, Paul D Maroni, Elizabeth R Kessler, Claire Stokes, Carrye R Cost, Brian S Greffe, Timothy P Garrington, Arthur K Liu, Nicholas G Cost
INTRODUCTION: Testicular germ cell tumors (GCTs) are the most common solid tumor among adolescent and young adult (AYA) males. AYA patients with GCTs most typically have non-seminoma compared with seminoma, and accordingly there are fewer data reported on the AYA experience with testicular seminoma. OBJECTIVE: To evaluate national trends in postoperative treatment and overall survival (OS) outcomes in testicular seminoma by age group, specifically comparing AYAs with older adults...
January 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28152873/survival-as-a-measure-of-quality-of-cancer-care-and-advances-in-therapy-lessons-learned-from-analyses-of-the-national-cancer-data-base-ncdb
#15
Bryan E Palis, Ryan M McCabe, E Greer Gay, Katherine Mallin, Ashley Loomis, David P Winchester, Daniel P McKellar
: 173 Background: Many quality metrics of cancer care are process measures, based on whether a patient received recommended treatment for diagnosis and stage of their disease. Survival is dependent on patient characteristics, disease specifics, and care received (surgery, systemic therapies, radiation). Some argue survival is the ultimate measure of cancer care quality. Survival calculated from registry data may be a better indication of the real effects of new therapies as it contains a broad representation of patients who may not meet the eligibility criteria for clinical trials...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152856/the-influence-of-treatment-facility-volume-on-the-mortality-of-multiple-myeloma-patients
#16
Adam C Bartley, Cynthia S Crowson, Nilay D Shah, Elizabeth B Habermann, Sara Holton, David R Holmes
: 284 Background: MM is an uncommon cancer with annual incidence of only 27,000 cases in the US. Our study determined the extent to which the number of MM patients treated annually in a treatment facility affected all-cause mortality. METHODS: We used the National Cancer Data Base (NCDB) to identify adult patients with MM diagnosed from 2003-2011. NCDB is sourced from over 1,500 Commission on Cancer-accredited cancer registries representing 70% of cancer cases in the US...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152799/disparity-in-early-mortality-among-racial-groups-with-multiple-myeloma-in-the-united-states-a-national-cancer-data-base-study-of-108-352-patients
#17
Adam C Bartley, Ronald S Go
: 311 Background: Previous population-based studies have shown variations in disease incidence and overall survival (OS) among multiple myeloma (MM) patients (pts) from different ethnic and racial backgrounds. However, the impact of race and ethnicity on early mortality (EM) or death in the first year after the diagnosis of MM is less well known. METHODS: Pts with MM diagnosed from 2000-2011 were identified in the NCDB. We obtained data associated with socio-demographics, type and location of care facility, as well as the use of autologous stem cell transplant (ASCT) as an initial treatment option...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152787/why-do-patients-still-go-to-low-volume-hospitals-for-complex-cancer-surgery
#18
Karl Y Bilimoria, Katherine Mallin, Clifford Y Ko, David P Winchester
: 300 Background: While a strong volume-outcome relationship exists for many cancer operations, patients continue to undergo these operations at low-volume centers. METHODS: Patients were identified from the National Cancer Data Base (NCDB) from 2010-2014 who underwent resection for bladder, breast, esophagus, stomach, pancreas, lung and rectal malignancies from 1,406 hospitals. Low-volume hospitals were defined as those in the bottom quartile by surgical volume for each operation separately...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152780/changing-patterns-of-care-for-locally-advanced-non-small-cell-lung-cancer-nsclc-implications-for-quality-initiatives
#19
Peter Edward Gabriel, Wensheng Guo, Sandhya Upasani, Marjorie van der Pas, Timothy E Schultheiss, Joel W Goldwein, John Paul Christodouleas
: 302 Background: Our purpose was to assess the utilization of dose escalated radiotherapy (RT) in Stage III NSCLC patients in the United States from 2004-2013, a period when no Level 1 evidence on dose escalation was published. METHODS: Data on all NSCLC patients treated with RT were extracted from the National Oncology Data Alliance (NODA), a pooled database of cancer registries from >150 US hospitals. The NODA contains the same data submitted to state cancer registries and SEER, but also contains RT dose fields that are manually verified by trained staff...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152734/effect-of-insurance-status-on-receiving-standard-quality-care-treatment-in-patients-with-stage-iii-colon-cancer
#20
Lihong Liu, Hemangini Dhaibar, Glenn Morris Mills, Runhua Shi
: 45 Background: NCCN (National comprehensive Cancer network) recommends adjuvant chemotherapy for stage 3 colon cancer patients. National Cancer Data Base (NCDB) data were analyzed to investigate the impact of insurance status on receiving standard quality of care with adjuvant chemotherapy for stage 3 colon cancer patients. METHODS: Data was analyzed from 11,563 men and women, between ages 18-80 years, registered in the NCDB who were diagnosed with stage 3 colon cancer between 1998 and 2011 and had follow-ups to end of 2012...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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