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https://www.readbyqxmd.com/read/28074326/minimally-invasive-staging-surgery-in-women-with-early-stage-endometrial-cancer-analysis-of-the-national-cancer-data-base
#1
Amy J Bregar, Alexander Melamed, Elisabeth Diver, Joel T Clemmer, Shitanshu Uppal, John O Schorge, Laurel W Rice, Marcela G Del Carmen, J Alejandro Rauh-Hain
PURPOSE: The aim of this study was to determine factors associated with the adoption of minimally invasive surgery (MIS) compared with laparotomy in the treatment of endometrial cancer and to compare surgical outcomes and survival between these two surgical modalities. METHODS: We utilized the National Cancer Data Base (NCDB) to identify women diagnosed with presumed early-stage endometrial cancer between 2010 and 2012. We also identified factors associated with the performance of MIS and utilized propensity score matching to create a matched cohort of women who underwent minimally invasive staging surgery or laparotomy for surgical staging...
January 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28062931/fewer-reoperations-after-lumpectomy-for-breast-cancer-with-neoadjuvant-rather-than-adjuvant-chemotherapy-a-report-from-the-national-cancer-database
#2
Jeffrey Landercasper, Barbara Bennie, Benjamin M Parsons, Leah L Dietrich, Caprice C Greenberg, Lee G Wilke, Jared H Linebarger
BACKGROUND: Reoperations occur frequently after initial lumpectomy for breast cancer. The authors hypothesized that the receipt of neoadjuvant chemotherapy (NAC) is associated with fewer reoperations. METHODS: The association between timing of chemotherapy and reoperation rates (ROR) after lumpectomy was investigated for patients with stages 1-3 breast cancer in the National Cancer Database (NCDB) from 2010 to 2013 by multivariable logistic regression modeling. Then propensity score-matching was performed...
January 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28061532/palliative-interventions-for-hepatocellular-carcinoma-patients-analysis-of-the-national-cancer-database
#3
Abdulrahman Y Hammad, Jared R Robbins, Kiran K Turaga, Kathleen K Christians, T Clark Gamblin, Fabian M Johnston
BACKGROUND: Palliative therapies are provided to a subset of hepatocellular carcinoma (HCC) patients with the aim of providing symptomatic relief, better quality of life and improved survival. The present study sought to assess and compare the efficacy of different palliative therapies for HCC. METHODS: The National Cancer Database (NCDB), a retrospective national database that captures approximately 70% of all patients treated for cancer in the US, was queried for patients with HCC who were deemed unresectable from 1998-2011...
November 22, 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28043773/pulmonary-sarcomatoid-carcinoma-an-analysis-of-the-national-cancer-data-base
#4
Conor E Steuer, Madhusmita Behera, Yuan Liu, Chao Fu, Theresa W Gillespie, Nabil F Saba, Dong M Shin, Rathi N Pillai, Suchita Pakkala, Taofeek K Owonikoko, Fadlo R Khuri, Suresh S Ramalingam
INTRODUCTION: Pulmonary sarcomatoid carcinoma (PSC) is a grouping of 5 rare non-small-cell lung cancer (NSCLC) subtypes. We studied the clinical characteristics and outcomes of PSC utilizing the National Cancer Data Base (NCDB), an oncology outcomes database. METHODS: The NCDB lung cancer database was queried from 1998 to 2011 for PSC using ICD-O-3 codes. Data were extracted for patient demographics, tumor pathology, treatment, and outcomes. Overall survival (OS) data were available for patients diagnosed from 1998 to 2006 and comorbidity data from 2003 to 2011...
December 7, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28035322/micropapillary-bladder-cancer-insights-from-the-national-cancer-database
#5
Wilson Sui, Justin T Matulay, Maxwell B James, Ifeanyi C Onyeji, Marissa C Theofanides, Arindam RoyChoudhury, G Joel DeCastro, Sven Wenske
Introduction: Micropapillary bladder cancer (MPBC) is a variant histology of urothelial carcinoma (UC) that is associated with poor outcomes however given its rarity, little is known outside of institutional reports. We sought to use a population-level cancer database to assess survival outcomes in patients treated with surgery, radiation therapy and/or chemotherapy. Materials and Methods: The National Cancer Database (NCDB) was queried for all cases of MPBC and UC using International Classification of Disease-O-3 morphologic codes between 2004-2014...
October 27, 2016: Bladder Cancer
https://www.readbyqxmd.com/read/28026871/radiation-therapy-dose-is-associated-with-improved-survival-for-unresected-anaplastic-thyroid-carcinoma-outcomes-from-the-national-cancer-data-base
#6
Todd A Pezzi, Abdallah S R Mohamed, Tommy Sheu, Pierre Blanchard, Vlad C Sandulache, Stephen Y Lai, Maria E Cabanillas, Michelle D Williams, Christopher M Pezzi, Charles Lu, Adam S Garden, William H Morrison, David I Rosenthal, Clifton D Fuller, G Brandon Gunn
BACKGROUND: The outcomes of patients with unresected anaplastic thyroid carcinoma (ATC) from the National Cancer Data Base (NCDB) were assessed, and potential correlations were explored between radiation therapy (RT) dose and overall survival (OS). METHODS: The study cohort was comprised of patients who underwent either no surgery or grossly incomplete resection. Correlates of OS were explored using univariate analysis and multivariable analysis (MVA). RESULTS: In total, 1288 patients were analyzed...
December 27, 2016: Cancer
https://www.readbyqxmd.com/read/28024733/racial-disparities-in-anaplastic-oligodendroglioma-an-analysis-on-1643-patients
#7
Jacob Y Shin, Ja Kyoung Yoon, Aidnag Z Diaz
The objective of our study is to determine the influence of race on overall survival (OS) for anaplastic oligodendroglioma (AO). Data were extracted from the National Cancer Data Base (NCDB). Chi-square test, Kaplan-Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 1643 patients with AO were identified. 1386 (84.3%) were White, 83 (5.0%) Black, 133 (8.1%) Hispanic, and 41 (2.5%) were Asian. White and Black patients were significantly older than Hispanic and Asian patients (49...
December 23, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28024690/trends-in-stereotactic-body-radiation-therapy-for-stage-i-small-cell-lung-cancer
#8
John M Stahl, Christopher D Corso, Vivek Verma, Henry S Park, Sameer K Nath, Zain A Husain, Charles B Simone, Anthony W Kim, Roy H Decker
OBJECTIVES: We aimed to report trends in stereotactic body radiation therapy (SBRT) utilization, dose prescriptions, and chemotherapy administration for stage I small cell lung cancer (SCLC) in the United States. MATERIALS AND METHODS: The National Cancer Data Base (NCDB) was used to identify patients with cT1-2 N0 SCLC treated with SBRT between 2004 and 2013. Trends in SBRT use and dose prescription were analyzed over time. Multivariable logistic regression was used to determine factors associated with the administration of chemotherapy with SBRT...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28024648/extent-of-lymphadenectomy-is-associated-with-improved-overall-survival-after-esophagectomy-with-or-without-induction%C3%A2-therapy
#9
Pamela Samson, Varun Puri, Stephen Broderick, G Alexander Patterson, Bryan Meyers, Traves Crabtree
BACKGROUND: National Comprehensive Cancer Network (NCCN) guidelines recommend sampling 15 or more lymph nodes during esophagectomy. The proportion of patients meeting this guideline is unknown, as is its influence on overall survival (OS). METHODS: Univariate analysis and logistic regression were performed to identify variables associated with sampling 15 or more lymph nodes among patients undergoing esophagectomy in the National Cancer Data Base (NCDB). The NCCN guideline was evaluated in Cox proportional hazards modeling, along with alternative lymph node thresholds...
December 23, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28012794/improved-overall-survival-with-adjuvant-radiotherapy-for-high-intermediate-and-high-risk-stage-i-endometrial-cancer
#10
Matthew M Harkenrider, William Adams, Alec M Block, Stephanie Kliethermes, William Small, Surbhi Grover
BACKGROUND/PURPOSE: To perform a large analysis of Stage I endometrioid-type endometrial cancer patients to determine the impact of adjuvant radiotherapy (ART) on survival. MATERIAL/METHODS: 132,976 FIGO Stage I endometrioid-type endometrial cancer patients treated surgically were identified within the National Cancer Database (NCDB) comprising Commission on Cancer facilities in the United States. Patients were categorized as observation (OBS) or ART (vaginal brachytherapy, external beam radiotherapy, or both)...
December 21, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28012064/patterns-of-care-and-treatment-outcomes-of-patients-with-craniopharyngioma-in-the-national-cancer-database
#11
Yuan J Rao, Comron Hassanzadeh, Benjamin Fischer-Valuck, Michael R Chicoine, Albert H Kim, Stephanie M Perkins, Jiayi Huang
To investigate the patterns of care and outcomes in patients with craniopharyngioma in the National Cancer Data Base (NCDB). This study included 697 patients (166 pediatric and 531 adult cases) treated for craniopharyngioma between 2004 and 2012 in the NCDB. Adjuvant radiotherapy (RT) was defined if within 6 months of surgery. Limited surgery (LS) was defined as biopsy or subtotal resection. Proportional-hazards models were used to evaluate associations between covariates and overall survival (OS). A time-dependent analysis of RT was performed to account for early deaths after surgery...
December 23, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28000076/national-trends-in-the-use-of-neoadjuvant-chemotherapy-for-hormone-receptor-negative-breast-cancer-a-national-cancer-data-base-study
#12
Carlos A Puig, Tanya L Hoskin, Courtney N Day, Elizabeth B Habermann, Judy C Boughey
BACKGROUND: Neoadjuvant chemotherapy (NAC) downstages tumor size and nodal disease. This study evaluates national practice patterns of NAC use in hormone receptor-negative breast cancer. METHODS: We identified patients in the National Cancer Data Base (NCDB) with hormone receptor-negative invasive breast cancer (2004-2012). Univariate and multivariable logistic regression was used to assess associations and trends across time. RESULTS: Of 171,985 patients, 130,723 (76...
December 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27993697/national-accreditation-program-for-breast-centers-accreditation-demonstrates-improved-compliance-with-post-mastectomy-radiation-therapy-quality-measure
#13
Elizabeth R Berger, Chihsiung E Wang, Cary S Kaufman, Ted J Williamson, Julio A Ibarra, Karen Pollitt, Richard J Bleicher, James L Connolly, David P Winchester, Katharine A Yao
BACKGROUND: The National Accreditation Program for Breast Centers (NAPBC) was established in 2008 by the American College of Surgeons as a quality improvement program for patients with breast disease. An NAPBC quality measure states post-mastectomy patients with ≥4 positive lymph nodes should receive lymph node radiation therapy (PMRT). Our objective was to examine how NAPBC accreditation has affected compliance with this quality measure. STUDY DESIGN: Women who underwent mastectomy at either an NAPBC-accredited center or a CoC only accredited hospital were identified (2006-2013) in the National Cancer Data Base(NCDB)...
December 16, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27979711/reliability-of-the-american-college-of-surgeons-commission-on-cancer-s-quality-of-care-measures-for-hospital-and-surgeon-profiling
#14
Jason B Liu, Kristopher M Huffman, Bryan E Palis, Lawrence N Shulman, David P Winchester, Clifford Y Ko, Bruce L Hall
BACKGROUND: Efforts to improve healthcare quality involve profiling hospitals and providers. Whether cancer-specific measures can be reliably employed for profiling purposes has not reported. STUDY DESIGN: Hospitals and surgeons were profiled with three measures assessing the adequacy of lymphadenectomy for colon (12RLN), gastric (G15RLN), and non-small cell lung (10RLN) cancers using hierarchical models. National Cancer Data Base (NCDB) cases spanning 2010-2013 were included if they met measure eligibility...
November 18, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27969456/mini01-09-outcomes-of-early-stage-large-cell-neuroendocrine-lung-carcinoma-lcnelc-a-national-cancer-database-ncdb-analysis-topic-medical-oncology
#15
Lara Kujtan, Kevin F Kennedy, Sashidhar Manthravadi, J Russell Davis, Janakiraman Subramanian
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27965134/national-rise-of-primary-pancreatic-carcinoid-tumors-comparison-to-functional-and-non-functional-pancreatic-neuroendocrine-tumors
#16
Gyulnara G Kasumova, Omidreza Tabatabaie, Mariam F Eskander, Abhishek Tadikonda, Sing Chau Ng, Jennifer F Tseng
BACKGROUND: New guidelines recommend differentiating between carcinoid and pancreatic neuroendocrine tumors (PNETs) during clinical trials. However, little is known about the behavior and incidence of primary pancreatic carcinoid tumors. STUDY DESIGN: Retrospective cohort study utilizing the National Cancer Data Base (NCDB) to identify adults with primary PNETs diagnosed between 2004 and 2013. The Kaplan-Meier method was used to evaluate overall survival and multivariate Cox proportional hazards model was used to assess the hazard of death in resected patients...
December 10, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27923615/impact-of-facility-type-and-surgical-volume-on-10-year-survival-in-patients-undergoing-hepatic-resection-for-hepatocellular-carcinoma
#17
Brandon C Chapman, Alessandro Paniccia, Patrick W Hosokawa, William G Henderson, Douglas M Overbey, Wells Messersmith, Martin D McCarter, Ana Gleisner, Barish H Edil, Richard D Schulick, Csaba Gajdos
BACKGROUND: Previous studies have demonstrated improved in-hospital mortality following hepatic resection for hepatocellular carcinoma (HCC) at teaching hospitals. The objective of this study was to evaluate if resection of HCCs at academic cancer programs (ACP) is associated with improved 10-year survival. STUDY DESIGN: Using the NCDB (1998-2011), we evaluated patients undergoing hepatic resection for HCC at ACPs, comprehensive community cancer programs (CCCPs), and community cancer programs (CCPs)...
December 3, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27899201/revisiting-milan-cervical-cancer-study-do-the-original-findings-hold-in-the-era-of-chemotherapy
#18
W Ross Green, Lara Hathout, Atif J Khan, Mohamed A Elshaikh, Sushil Beriwal, William Small, Omar Mahmoud
BACKGROUND: The primary treatment of early stage cervical carcinoma (IB-IIA) is either surgery or radiation therapy based on the pivotal Milan randomized study published twenty years ago. In the presence of high-risk features, the gold standard treatment is concurrent chemotherapy and radiation therapy (CRT) whether it is the in the postoperative or the definitive setting. Using the National Cancer Data Base (NCDB), the goal of our study is to compare the outcomes of surgery and radiation therapy in the chemotherapy era...
November 26, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27893532/the-effect-of-hospital-volume-on-breast-cancer-mortality
#19
Rachel A Greenup, Samilia Obeng-Gyasi, Samantha Thomas, K Houck, Whitney O Lane, Rachel C Blitzblau, Terry Hyslop, E Shelley Hwang
OBJECTIVE: The aim of this study was to determine whether hospital volume was associated with mortality in breast cancer, and what thresholds of case volume impacted survival. BACKGROUND: Prior literature has demonstrated improved survival with treatment at high volume centers among less common cancers requiring technically complex surgery. METHODS: All adults (18 to 90 years) with stages 0-III unilateral breast cancer diagnosed from 2004 to 2012 were identified from the American College of Surgeons National Cancer Data Base (NCDB)...
November 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27862623/patterns-of-care-and-survival-outcomes-in-the-treatment-of-esophageal-melanoma
#20
Joseph P Weiner, Meng Shao, David Schwartz, Andrew Wong, David Schreiber
Because of the rarity of esophageal melanoma, the optimal management of this disease is limited. The pooled dataset in the National Cancer Database (NCDB) was used to identify the prognostic factors and treatment outcomes. Patients who were diagnosed with esophageal melanoma between 2004 and 2011 were identified. Patients were stratified as either localized (T1-4N0M0), regional (T1-4N+M0), or metastatic (M1). The primary endpoint of this study was overall survival (OS) which was analyzed using the Kaplan-Meier method and multivariate Cox regression, which was performed to identify potential factors influencing survival...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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