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O S Eng, R A Nelson, I Konstantinidis, J Chao, L Erhunmwunsee, D J Raz, J Y Kim
Trimodality therapy with neoadjuvant chemoradiation followed by surgery has emerged as the standard of care for the treatment of locally advanced esophageal cancer. Yet, there is considerable variation in survival within this population. We sought to analyze factors associated with survival after trimodality therapy in esophageal adenocarcinoma. We identified 4,679 patients from the National Cancer Database (NCDB) of the American College of Surgeons who received chemotherapy and radiation prior to surgery for esophageal adenocarcinoma from 2006 to 2013...
March 8, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Jeremy P Harris, Michelle M Chen, Ryan K Orosco, Davud Sirjani, Vasu Divi, Wendy Hara
Importance: Shortening the time from surgery to the start of radiation (TS-RT) is a consideration for physicians and patients. Although the National Comprehensive Cancer Network recommends radiation to start within 6 weeks, a survival benefit with this metric remains controversial. Objective: To determine the association of delayed TS-RT with overall survival (OS) using a large cancer registry. Design, Setting, and Participants: In this observational cohort study, 25 216 patients with nonmetastatic stages III to IV head and neck cancer were identified from the National Cancer Database (NCDB)...
March 8, 2018: JAMA Otolaryngology—Head & Neck Surgery
Zachary E Stiles, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, Lei Dong, Jim Y Wan, Michael G Martin, Paxton V Dickson
BACKGROUND AND OBJECTIVES: Outcomes and recommendations regarding adjuvant therapy (AT) for stage I ampullary adenocarcinoma (AAC) are inadequately described. We sought to determine factors associated with survival and better define the impact of AT. METHODS: The NCDB was queried for stage I AAC patients undergoing resection. We evaluated variables influencing the administration of AT and affecting survival, including the receipt of AT. RESULTS: Five hundred thirty-seven patients were identified...
March 8, 2018: Journal of Surgical Oncology
Brendan M Browne, Kristian D Stensland, Matthew J Moynihan, David Canes
BACKGROUND: The purpose of this study was to analyze contemporary trends for diagnosis and treatment of upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: We identified all cases of UTUC in the National Cancer Database (NCDB) between 2004 and 2013. Data comprising tumor, patient, and facility factors were extracted. Treatment data for surgery and chemotherapy were also collected. Comparisons used χ2 testing. RESULTS: Over this 10-year period, the sex and age distribution of UTUC was stable at 60% male and median age of 72 years...
February 5, 2018: Clinical Genitourinary Cancer
Ernest Barthélemy, Joshua Loewenstern, Neeraja Konuthula, Margaret Pain, Jordan Hall, Satish Govindaraj, Joshua Bederson, Raj K Shrivastava
PURPOSE: The initial management of atypical meningiomas poses a distinct clinical challenge in that treatment protocols have not been fully established, and outcomes, especially differences by patient age, have not been broadly measured. The National Cancer Database (NCDB) allows for analysis of a large, diverse patient population to determine clinical parameters and survival outcomes based on the initial treatment of patients with atypical meningiomas. METHODS: Analysis of the NCDB yielded 3611 atypical meningioma patients treated between 2008 and 2012...
March 2, 2018: Journal of Cancer Research and Clinical Oncology
Amy Voci, Bradley Bandera, Emily Ho, Jihey Lee, Melanie Goldfarb, Maggie DiNome
NCCN guidelines recommend tamoxifen (TAM) for adjuvant treatment of ductal carcinoma in situ (DCIS). TAM has side effects that can potentially complicate treatment recommendations and patient acceptance. It is unknown how well-accepted this recommended therapy is for the adolescent and young adult (AYA) patient population with DCIS. The NCDB was used to identify patients aged 15-39 with DCIS treated between 2000 and 2012. Patient demographic, socioeconomic, and treatment data were collected. Chi-squared test and multivariate analysis were used for statistical assessment...
March 2, 2018: Breast Journal
John R Bergquist, Harsh N Shah, Elizabeth B Habermann, Matthew C Hernandez, Tommy Ivanics, Michael L Kendrick, Rory L Smoot, David M Nagorney, Mitesh J Borad, Robert R McWilliams, Mark J Truty
BACKGROUND: Ideal oncologic management of gallbladder carcinoma (GBCA) after complete surgical resection is unclear. We sought to define benefit of post-resection adjuvant systemic chemotherapy alone in T2 or greater gallbladder carcinoma utilising a large national dataset. STUDY DESIGN: The National Cancer Data Base (NCDB) 2004-2012 cohort was retrospectively reviewed for patients with GBCA (T2+) undergoing curative-intent resection and surviving at least 6 weeks...
February 26, 2018: International Journal of Surgery
Shreyas S Joshi, Elizabeth Handorf, David Strauss, Andres F Correa, Alexander Kutikov, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Robert G Uzzo, Marc C Smaldone, Daniel M Geynisman
Importance: Penile cancer is an uncommon disease with minimal level I evidence to guide therapy. The National Comprehensive Cancer Network (NCCN) guidelines advocate a lymph node dissection (LND) or radiotherapy with consideration of perioperative chemotherapy for all patients with lymph node-positive (LN+) penile cancer without metastasis. Objectives: To determine temporal trends in use of chemotherapy for patients with LN+ penile cancer without metastasis and to evaluate outcomes between those who did or did not receive LND, chemotherapy, and radiotherapy...
March 1, 2018: JAMA Oncology
Ying Huang, Wei Chen, Waqar Haque, Vivek Verma, Yan Xing, Bin S Teh, Edward Brian Butler
The number of elderly patients with cancer is increasing. Medical comorbidities are more common in this population. Little is known regarding the prognostic relevance of comorbidities in elderly patients with nasopharyngeal carcinoma (NPC). Using the National Cancer Data Base (NCDB), we queried patients age >65 years diagnosed with NPC and treated with definitive radiation between 2004 and 2012 to examine the association between comorbidity and survival outcomes. Comorbidity was assessed with the Charlson Comorbidity Index (CCI)...
March 1, 2018: Cancer Medicine
Carl M Post, Chi Lin, Sebastian Adeberg, Mrigank Gupta, Weining Zhen, Vivek Verma
BACKGROUND: The standard of care for T1N0 nasopharyngeal cancer (NPC) is definitive radiation therapy (RT). However, practice patterns in the elderly may not necessarily follow national guidelines. Herein, we investigated national practice patterns for T1N0 NPC. MATERIALS AND METHODS: The National Cancer Data Base (NCDB) was queried for clinical T1N0 primary NPC cases (2004-2013) in patients ≥70 years old. Patient, tumor, and treatment parameters were extracted...
March 2018: Anticancer Research
Chang Su, Cuiying Peng, Ena Agbodza, Harrison X Bai, Yuqian Huang, Giorgos Karakousis, Paul J Zhang, Zishu Zhang
BACKGROUND: The utilization and impact of the studies published using the National Cancer Database (NCDB) is currently unclear. In this study, we aim to characterize the published studies, and identify relatively unexplored areas for future investigations. METHODS: A literature search was performed using PubMed in January 2017 to identify all papers published using NCDB data. Characteristics of the publications were extracted. Citation frequencies were obtained through the Web of Science...
March 2018: Medicine (Baltimore)
Benjamin J Resio, Alexander S Chiu, Jessica Hoag, Andrew P Dhanasopon, Justin D Blasberg, Daniel J Boffa
BACKGROUND: Primary Salivary Type Lung Cancers (PSTLC) such as Adenoid Cystic Carcinoma (ACC) and Mucoepidermoid Carcinoma (MEC) are uncommon primary lung tumors that given their rarity, remain incompletely understood. This study aimed to characterize the management and outcomes associated with these less common pulmonary malignancies. METHODS: Patients in the National Cancer Database (NCDB) diagnosed with primary lung and bronchial (not tracheal) MEC and ACC between 2004-2014 were identified...
February 24, 2018: Annals of Thoracic Surgery
Amy C Moreno, Waqar Haque, Vivek Verma, Penny Fang, Steven H Lin
BACKGROUND: Following complete resection of pN2 non-small cell lung cancer (NSCLC), national guidelines recommend either sequential (sCRT) or concurrent chemoradiotherapy (cCRT). This is the largest study to date evaluating survival between both approaches. In sCRT patients, sequencing 'chemotherapy first' versus 'radiotherapy first' was also addressed. METHODS: The National Cancer Data Base (NCDB) was queried for patients with primary NSCLC undergoing surgery (without neoadjuvant radiotherapy or chemotherapy), pN2 disease with negative surgical margins, and receiving postoperative CRT...
February 26, 2018: Annals of Surgical Oncology
Anna Lee, Irini Youssef, Virginia W Osborn, Joseph Safdieh, Daniel J Becker, David Schreiber
Multiple studies have identified O6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation status to be an important prognostic factor in glioblastoma (GBM). We used the National Cancer Data Base (NCDB) to analyze completeness of coding for MGMT as well as to compare outcomes of GBM patients treated with adjuvant chemoradiation based on MGMT promoter methylation status (positive, negative, unknown). Patients diagnosed with GBM from 2010 to 2012 who received adjuvant chemoradiation were identified...
February 23, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Sarah B Fisher, Yi-Ju Chiang, Barry W Feig, Janice N Cormier, Kelly K Hunt, Keila E Torres, Christina L Roland
BACKGROUND: The 8th edition American Joint Committee on Cancer (AJCC) staging for soft tissue sarcomas of the trunk/extremities divides T stage into four categories and upstages nodal disease to stage IV. We used the National Cancer Database (NCDB) to evaluate the prognostic power of the new system. METHODS: A total of 26,144 patients were identified from the NCDB from 2004 to 2013. Overall survival (OS) was compared using Kaplan-Meier and Cox proportional hazard models...
February 21, 2018: Annals of Surgical Oncology
Virginia Wedell Osborn, Babak Givi, Justin Rineer, Dylan Roden, Niki Sheth, Ariel Lederman, Evangelia Katsoulakis, Kenneth Hu, David Schreiber
BACKGROUND: Postoperative chemoradiotherapy (CRT) is considered standard of care in patients with locally advanced head and neck cancer with positive margins and/or extracapsular extension (ECE). METHODS: The National Cancer Data Base (NCDB) was queried to identify patients with squamous cell carcinoma of the head and neck with stages III to IVB disease or with positive margins and/or ECE diagnosed between 2004 and 2012 receiving postoperative radiotherapy (RT)...
February 16, 2018: Head & Neck
Nabil Wasif, David Etzioni, Elizabeth B Habermann, Amit Mathur, Barbara A Pockaj, Richard J Gray, Yu-Hui Chang
BACKGROUND: Although major cancer surgery at a high-volume hospital is associated with lower postoperative mortality, the use of such hospitals may not be equally distributed. OBJECTIVE: Our aim was to study socioeconomic and racial differences in cancer surgery at Commission on Cancer (CoC)-accredited high-volume hospitals. METHODS: The National Cancer Database (NCDB) was used to identify patients undergoing surgery for colon, esophageal, liver, and pancreatic cancer from 2003 to 2012...
February 15, 2018: Annals of Surgical Oncology
Anna Lee, Baho Sidiqi, Arthur Wang, Joseph Safdieh, David Schreiber
OBJECTIVE: Several small (<100 patients) studies have been suggestive of a survival benefit associated with postoperative radiation for intracranial hemangiopericytoma. Given the rarity of this disease, we sought to examine the patterns of care and outcomes of this tumor in the National Cancer Database (NCDB). PATIENTS AND METHODS: We accessed the NCDB to identify patients with intracranial hemangiopericytoma between 2004-2012. Patients were categorized by surgical status, postoperative radiation usage, and location (meningeal or brain parenchyma)...
February 5, 2018: Clinical Neurology and Neurosurgery
Emi J Yoshida, Michael Luu, John M David, Sungjin Kim, Alain Mita, Kevin Scher, Stephen L Shiao, Mourad Tighiouart, Allen S Ho, Zachary S Zumsteg
BACKGROUND: Postoperative concomitant chemoradiotherapy (CRT) improves outcomes for younger adults with head and neck squamous cell carcinoma (HNSCC) and positive margins or extranodal extension (ENE), but its benefit for older adults is not well established. METHODS: Patients from the National Cancer Data Base (NCDB) with HNSCC undergoing curative-intent resection, neck dissection, and postoperative radiation with positive margins or ENE were identified. RESULTS: This analysis included 1199 patients aged ≥ 70 years with median follow-up of 42...
February 8, 2018: Head & Neck
Daniel Morgensztern, Pamela S Samson, Saiama N Waqar, Siddhartha Devarakonda, Clifford G Robinson, Ramaswamy Govindan, Varun Puri
BACKGROUND: Although adjuvant chemotherapy improves survival in patients with completely resected NSCLC, it is also associated with potentially disabling or lethal adverse events. Because there is limited information on the early mortality among patients undergoing adjuvant chemotherapy, we used the National Cancer Database to calculate the percentage of deaths within the first 6 months of starting chemotherapy. METHODS: The National Cancer Database was queried for patients age 18 or older in whom stage IB to IIIA NSCLC had been diagnosed between 2004 and 2012 and who had received multiagent adjuvant chemotherapy starting within 120 days from the surgical resection with negative surgical margins...
February 2, 2018: Journal of Thoracic Oncology
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