Yohei Ando, Mohamad Dbouk, Takeichi Yoshida, Helena Saba, Elizabeth Abou Diwan, Kanako Yoshida, Ali Dbouk, Amanda L Blackford, Ming-Tseh Lin, Anne Marie Lennon, Richard A Burkhart, Jin He, Lori Sokoll, James R Eshleman, Marcia Irene Canto, Michael Goggins
PURPOSE: Circulating carbohydrate antigen 19-9 (CA19-9) levels reflect FUT3 and FUT2 fucosyltransferase activity. Measuring the related glycan, DUPAN-2, can be useful in individuals unable to synthesize CA19-9. We hypothesized that similar to CA19-9, FUT functional groups determined by variants in FUT3 and FUT2 influence DUPAN-2 levels, and having tumor marker reference ranges for each functional group would improve diagnostic performance. MATERIALS AND METHODS: Using a training/validation study design, FUT2 / FUT3 genotypes were determined in 938 individuals from Johns Hopkins Hospital: 607 Cancer of the Pancreas Screening (CAPS) study subjects with unremarkable pancreata and 331 with pancreatic ductal adenocarcinoma (PDAC)...
March 8, 2024: Journal of Clinical Oncology