Katherine J Chou, Trevor Croft, Skyler Hebdon, Lauren R Magnusson, Wei Xiong, Luis H Reyes, Xiaowen Chen, Emily Miller, Danielle M Riley, Sunnyjoy Dupuis, Kathrin A Laramore, Lisa M Keller, Dirk Winkelman, Pin-Ching Maness
Consolidated bioprocessing (CBP) of lignocellulosic biomass holds promise to realize economic production of second-generation biofuels/chemicals, and Clostridium thermocellum is a leading candidate for CBP due to it being one of the fastest degraders of crystalline cellulose and lignocellulosic biomass. However, CBP by C. thermocellum is approached with co-cultures, because C. thermocellum does not utilize hemicellulose. When compared with a single-species fermentation, the co-culture system introduces unnecessary process complexity that may compromise process robustness...
April 15, 2024: Metabolic Engineering