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https://www.readbyqxmd.com/read/28240007/delineation-of-margins-for-the-planning-target-volume-ptv-for-image-guided-radiotherapy-igrt-of-gastric-cancer-based-on-intrafraction-motion
#1
Paulina Leszczyńska, Wojciech Leszczyński, Jerzy Wydmański, Dębiec Kinga, Agnieszka Namysł Kaletka, Andrzej Tukiendorf, Leszek Hawrylewicz
Background: Application of the image-guided radiotherapy (IGRT) system for gastric cancer involving daily verification of patient positioning on the treatment machine allows minimisation of geometrical errors as a consequence of intra- and inter-fraction motion. The purpose of this study was to define the intrafraction motion in gastric cancer patients during a treatment session based on the IGRT system and designation of margins around the clinical target volume CTV (internal target volume ITV) necessary to delineate the planning target volume (PTV)...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239972/influence-of-mobile-phase-source-parameters-and-source-type-on-electrospray-ionization-efficiency-in-negative-ion-mode
#2
Anneli Kruve
Electrospray ionization (ESI) efficiency is known to be affected by the properties of the analytes, source design and source parameters. In this study, the ionization efficiency of 17 acidic compounds at various conditions in ESI negative ion mode was evaluated. Namely, the influence of organic solvent content in the mobile phase, ionization source parameters, ionization source geometry and functionality (conventional ESI, ESI with thermal focussing and with additional internal nebulizer gas) was studied. It was observed that the ionization efficiency in thermal focussing ESI is only marginally affected by the organic solvent composition, while for conventional ESI and ESI with internal nebulizer gas, the ionization efficiency increases significantly with increasing organic modifier content...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239964/training-in-metabolomics-research-ii-processing-and-statistical-analysis-of-metabolomics-data-metabolite-identification-pathway-analysis-applications-of-metabolomics-and-its-future
#3
S Barnes, H P Benton, K Casazza, S J Cooper, X Cui, X Du, J Engler, J H Kabarowski, S Li, W Pathmasiri, J K Prasain, M B Renfrow, H K Tiwari
Metabolomics is perhaps the most challenging of the -omics fields, given the complexity of an organism's metabolome and the rapid rate at which it changes. When one sets out to study metabolism there are numerous dynamic variables that can influence metabolism that must be considered. Recognizing the experimental challenges confronting researchers who undertake metabolism studies, workshops like the one at University of Alabama at Birmingham have been established to offer instructional guidance. A summary of the UAB course training materials is being published as a two-part Special Feature Tutorial...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239907/effects-of-oral-%C3%AE-lipoic-acid-administration-on-body-weight-in-overweight-or-obese-subjects-a-crossover-randomized-double-blind-placebo-controlled-trial
#4
Nong Li, Weili Yan, Xiaojuan Hu, Yongdi Huang, Fugang Wang, Weiguo Zhang, Qian Wang, Xiaoling Wang, Kehong Sun
OBJECTIVE: Alpha-lipoic acid (ALA) has shown beneficial properties on diabetes and obesity. The aim of this study was to examine the effects of oral ALA on body weight in subjects with overweight or obese. DESIGN: Single-centre, randomized, double-blind, crossover controlled study. PARTICIPANTS: A total of 166 subjects of Chinese Han ethnicity with a BMI ≥25 kg/m(2) were screened and 103 subjects fulfilled the study requirements, in terms of informed consent and participation to the study...
January 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28239906/complementary-medicine-for-treatment-of-agitation-and-delirium-in-older-persons-a-systematic-review-and-narrative-synthesis
#5
REVIEW
Ilana Levy, Samuel Attias, Eran Ben-Arye, Boaz Bloch, Elad Schiff
BACKGROUND: Agitation and delirium frequently occur in cognitively impaired older people. We conducted a systematic review with narrative synthesis of the literature aiming to assess effectiveness of complementary and alternative medicine (CAM) modalities to address these conditions. METHODS: Following preliminary search, we included 40 original researches on CAM treatment of delirium and agitation in older persons. Then, the quality of these studies was assessed using the Downs and Black Checklist and Quality Assessment Tool for Studies with Diverse Designs, and the effect sizes were calculated...
February 26, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28239868/determination-of-two-potential-toxicity-metabolites-derived-from-the-disruption-of-pksct-gene-in-monascus-aurantiacus-li-as3-4384
#6
Zhibing Huang, Baowei Su, Yang Xu, Laisheng Li, Yanping Li
BACKGROUND: We previously demonstrated that disruption of the pksCT gene of Monascus led to over 98% decrease in its citrinin production capacity in Monascus (PHDS26).Two potentially toxic compounds, monascopyridine A (MPA) and monascopyridine B (MPB), were found in the fermentation products of the pksCT gene-disrupted Monascus. Moreover, a rapid and reliable HPLC method was developed for the simultaneous determination of MPA and MPB. We studied the effects of various extraction parameters and designed an orthogonal experiment to investigate the importance of each factor...
February 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28239863/roaming-behaviour-of-dogs-in-four-remote-aboriginal-communities-in-the-northern-territory-australia-preliminary-investigations
#7
S Molloy, A Burleigh, S Dürr, M P Ward
OBJECTIVE: To estimate the home range (HR) and investigate the potential predictors for roaming of 58 dogs in four Aboriginal communities in the Northern Territory. DESIGN: Prospective study. PROCEDURE: Global positioning system (GPS) collars were attached to the dogs for 1-4 days, recording location fixes every 1-3 min. Utilisation distributions (UDs) and extended (95% isopleth) and core (50% isopleth) HRs of dogs were determined. Potential predictors of roaming were assessed...
March 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28239857/neospora-caninum-in-beef-herds-in-new-south-wales-australia-1-seroprevalence-study
#8
B J Moloney, P D Kirkland, C Heuer
OBJECTIVE: To determine the seroprevalence of Neospora caninum antibodies in beef breeding herds across New South Wales (NSW) and to determine if there are any differences associated with geographic location and other herd-level factors. METHODS: Cross-sectional survey of beef breeding cows (n = 3298) from 63 properties (approximately 55 cows per herd) sampled randomly from six regions in NSW using a multistage survey design. Samples were tested by ELISA for N...
March 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28239853/management-of-digital-mucous-cysts-a-systematic-review-and-treatment-algorithm
#9
REVIEW
Samer Jabbour, Elio Kechichian, Roger Haber, Roland Tomb, Marwan Nasr
Digital mucous cysts (DMC) are benign, highly recurrent lesions of the digits. To date, there is still no treatment agreement on the treatment of DMC. Herein, we review available data on treatment modalities, including both surgical and nonsurgical techniques, and to provide a practical algorithm for the management of DMC. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane databases. Articles studying the management of DMC were included in this review. A total of 40 articles were included in the review...
February 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28239838/which-matters-more-a-retrospective-cohort-study-of-headache-characteristics-and-diagnosis-type-in-soldiers-with-mtbi-concussion
#10
Alan G Finkel, Brian J Ivins, Juanita A Yerry, John S Klaric, Ann Scher, Y Sammy Choi
OBJECTIVE: To describe the diagnostic types and characteristics of headaches in soldiers with mild traumatic brain injury during the wars in Afghanistan and Iraq. BACKGROUND: Persistent post-traumatic headache interferes with returns to activity or duty. The most commonly cited headache diagnosis after concussion is migraine. We hypothesize that headache diagnosis type, eg, migraine, is not sufficient to predict relationships with occupational outcomes after concussion...
February 27, 2017: Headache
https://www.readbyqxmd.com/read/28239830/implant-survival-and-success-rates-in-patients-with-risk-factors-results-from-a-long-term-retrospective-study-with-a-10-to-18-years-follow-up
#11
F De Angelis, P Papi, F Mencio, D Rosella, S Di Carlo, G Pompa
OBJECTIVE: Risk factors for implant therapy are represented by all general and local conditions that through various mechanisms can increase either short-term and long-term failure risk. The aim of this study is to assess the implant survival and implant success rates with single and multiple risk factors. PATIENTS AND METHODS: To address the research purpose, a retrospective cohort study was designed and implemented, including a sample of 225 patients with a total of 871 implants placed...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239768/prostaglandin-e2-ep4-receptor-activation-attenuates-neuroinflammation-and-early-brain-injury-induced-by-subarachnoid-hemorrhage-in-rats
#12
Jie Xu, Zhen Xu, Ai Yan
Activation of E prostanoid 4 receptor (EP4) shows neuroprotective effects in multiple central nervous system (CNS) lesions, but the roles of EP4 receptor in subarachnoid hemorrhage (SAH) are not explored. This study was designed to research the effects of EP4 modulation on early brain injury (EBI) after experimental SAH in rats. We found that the administration of EP4 selective agonist AE1-329 significantly improved neurological dysfunction, blood brain barrier (BBB) damage and brain edema at 24 h after SAH...
February 27, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28239735/monte-carlo-simulation-of-magnetic-domain-structure-and-magnetic-properties-near-the-morphotropic-phase-boundary
#13
Songrui Wei, Sen Yang, Dong Wang, Xiaoping Song, Xiaoqin Ke, Yipeng Gao, Xiaoqi Liao, Yunzhi Wang
The morphotropic phase boundary (MPB), which is the boundary separating a tetragonal phase from a rhombohedral phase by varying the composition or mechanical pressure in ferroelectrics, has been studied extensively for decades because it can lead to strong enhancement of piezoelectricity. Recently, a parallel ferromagnetic MPB was experimentally reported in the TbCo2-DyCo2 ferromagnetic system and this discovery proposes a new way to develop potential materials with giant magnetostriction. However, the role of magnetic domain switching and spin reorientation near the MPB region is still unclear...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28239734/study-of-the-role-of-oxygen-vacancies-as-active-sites-in-reduced-graphene-oxide-modified-tio2
#14
Yanhui Zhang, Rongying Dai, Shirong Hu
In recent years, substantial efforts have been devoted to exploring reduced graphene oxide/TiO2 (RGO/TiO2) composite materials; however, there is still a paucity of reports on the construction of reduced graphene oxide/TiO2 with oxygen vacancies (RGO/TiO2-OV) via a facile two-step wet chemistry approach. In this work, we show a proof-of-concept study follow RGO introduced into TiO2 with oxygen vacancies, the role of oxygen vacancies as active sites in reduced graphene oxide-modified TiO2. The photocatalytic performance and related properties of blank-TiO2, blank-TiO2 with oxygen vacancies (blank-TiO2-OV), RGO/TiO2, and RGO/TiO2-OV were comparatively studied...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28239698/beneficial-effects-of-apple-peel-polyphenols-on-vascular-endothelial-dysfunction-and-liver-injury-in-high-choline-fed-mice
#15
Mengfan Jia, Daoyuan Ren, Yan Nie, Xingbin Yang
This study was designed to investigate the preventive effects of Red Fuji apple peel polyphenolic extract (APP) on vascular endothelial dysfunction and liver injury in mice fed a high choline diet. The mice were fed 3% dietary choline in drinking water for 8 weeks and displayed vascular dysfunction and liver damage (p < 0.01). The administration of APP at 600 and 900 mg per kg bw significantly elevated serum NO, HDL and 6-Keto-PGF1a levels and lowered serum TC, TG, LDL, ET-1 and TXB2 levels in the HC-fed mice...
February 27, 2017: Food & Function
https://www.readbyqxmd.com/read/28239668/evaluation-of-cognitive-impairment-in-elderly-population-with-hypertension-from-a-low-resource-setting-agreement-and-bias-between-screening-tools
#16
María Lazo-Porras, María A Pesantes, J Jaime Miranda, Antonio Bernabe-Ortiz
INTRODUCTION: The evaluation of cognitive impairment in adulthood merits attention in societies in transition and especially in people with chronic diseases. Screening tools available for clinical practice and epidemiological studies have been designed in high-income but not in resource-constrained settings. The aim of this study was to assess the agreement and bias of three common tools used for screening of cognitive impairment in people with hypertension: the modified Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Leganés Cognitive Test (LCT)...
December 2016: ENeurologicalSci
https://www.readbyqxmd.com/read/28239635/the-effects-of-a-cluster-randomized-controlled-workplace-intervention-on-sleep-and-work-family-conflict-outcomes-in-an-extended-care-setting
#17
Miguel Marino, Marie Killerby, Soomi Lee, Laura Cousino Klein, Phyllis Moen, Ryan Olson, Ellen Ernst Kossek, Rosalind King, Leslie Erickson, Lisa F Berkman, Orfeu M Buxton
OBJECTIVES: To evaluate the effects of a workplace-based intervention on actigraphic and self-reported sleep outcomes in an extended care setting. DESIGN: Cluster randomized trial. SETTING: Extended-care (nursing) facilities. PARTICIPANTS: US employees and managers at nursing homes. Nursing homes were randomly selected to intervention or control settings. INTERVENTION: The Work, Family and Health Study developed an intervention aimed at reducing work-family conflict within a 4-month work-family organizational change process...
December 2016: Sleep Health
https://www.readbyqxmd.com/read/28239606/influence-of-additive-manufactured-scaffold-architecture-on-the-distribution-of-surface-strains-and-fluid-flow-shear-stresses-and-expected-osteochondral-cell-differentiation
#18
Wim J Hendrikson, Anthony J Deegan, Ying Yang, Clemens A van Blitterswijk, Nico Verdonschot, Lorenzo Moroni, Jeroen Rouwkema
Scaffolds for regenerative medicine applications should instruct cells with the appropriate signals, including biophysical stimuli such as stress and strain, to form the desired tissue. Apart from that, scaffolds, especially for load-bearing applications, should be capable of providing mechanical stability. Since both scaffold strength and stress-strain distributions throughout the scaffold depend on the scaffold's internal architecture, it is important to understand how changes in architecture influence these parameters...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28239605/low-dimensional-synergistic-representation-of-bilateral-reaching-movements
#19
Martin K Burns, Vrajeshri Patel, Ionut Florescu, Kishore V Pochiraju, Ramana Vinjamuri
Kinematic and neuromuscular synergies have been found in numerous aspects of human motion. This study aims to determine how effectively kinematic synergies in bilateral upper arm movements can be used to replicate complex activities of daily living (ADL) tasks using a sparse optimization algorithm. Ten right-handed subjects executed 18 rapid and 11 natural-paced ADL tasks requiring bimanual coordination while sitting at a table. A position tracking system was used to track the subjects' arms in space, and angular velocities over time for shoulder abduction, shoulder flexion, shoulder internal rotation, and elbow flexion for each arm were computed...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28239596/genetic-diversity-of-atlantic-bluefin-tuna-in-the-mediterranean-sea-insights-from-genome-wide-snps-and-microsatellites
#20
Aglaia Antoniou, Panagiotis Kasapidis, Georgios Kotoulas, Constantinos C Mylonas, Antonios Magoulas
BACKGROUND: Elucidating the patterns of the Atlantic Bluefin tuna [ABFT, Thunnus thynnus (Linnaeus, 1758)] population structure constitutes a challenging task of great importance. Most of the unique challenges stem from its biology, as well as the attributes of the marine realm in which it disperses. Accurate information is urgently needed for stock assessment, and the identification of critical features to the persistence and adaptation of populations in order to formulate and adopt effective strategies for ABFT conservation and management...
December 2017: Journal of Biological Research
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