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https://www.readbyqxmd.com/read/28641405/biotransformation-of-ferulic-acid-to-protocatechuic-acid-by-corynebacterium-glutamicum-atcc-21420-engineered-to-express-vanillate-o-demethylase
#1
Naoko Okai, Takaya Masuda, Yasunobu Takeshima, Kosei Tanaka, Ken-Ichi Yoshida, Masanori Miyamoto, Chiaki Ogino, Akihiko Kondo
Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a lignin-derived phenolic compound abundant in plant biomass. The utilization of FA and its conversion to valuable compounds is desired. Protocatechuic acid (3,4-dihydroxybenzoic acid, PCA) is a precursor of polymers and plastics and a constituent of food. A microbial conversion system to produce PCA from FA was developed in this study using a PCA-producing strain of Corynebacterium glutamicum F (ATCC 21420). C. glutamicum strain F grown at 30 °C for 48 h utilized 2 mM each of FA and vanillic acid (4-hydroxy-3-methoxybenzoic acid, VA) to produce PCA, which was secreted into the medium...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28641373/estimating-influenza-vaccine-effectiveness-in-the-test-negative-design-using-alternative-control-groups-a-systematic-review-and-meta-analysis
#2
Shuo Feng, Benjamin J Cowling, Heath Kelly, Sheena G Sullivan
One important assumption in case-control studies is that control selection should be independent of exposure. Nevertheless, it has been hypothesized that virus interference might lead to a correlation between receipt of influenza vaccination and increased risk of infection with other respiratory viruses. We investigated if such a phenomenon might affect a commonly used study design to estimate influenza vaccination effectiveness (VE). We searched publications in Medline, PubMed and Web of Science. Twelve studies were identified reporting VE estimates using the test-negative design by three alternative control groups: (1) all patients testing negative for influenza, VEFLU-, (2) patients who tested positive for other respiratory viruses, VEORV+, or (3) patients who tested negative for all viruses tested, VEPAN-...
June 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28641285/role-of-glycyrrhizin-in-the-reduction-of-inflammation-in-diabetic-kidney-disease
#3
Vikram Thakur, Syeda Nargis, Mayra Gonzalez, Swetak Pradhan, Daniel Terreros, Munmun Chattopadhyay
BACKGROUND: Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes. Recent evidence suggests chronic inflammation to be one of the causal factors of DKD. The mechanisms entailed are not completely elucidated except that a variety of cytokines play a major role in this process. High mobility group box 1 (HMGB1) is a pro-inflammatory toll-like receptor-4 (TLR4)-binding cytokine that is involved in inflammation-associated gene expression. This investigation was designed to assess the involvement of HMGB1, TLR-4, and nuclear factor (NF)-κB in the development of DKD and to evaluate that whether blocking HMGB1 by its natural inhibitor Glycyrrhizin (GLC) can reduce the progression of the disease...
June 23, 2017: Nephron
https://www.readbyqxmd.com/read/28641276/atherosclerosis-and-the-hydrogen-sulfide-signaling-pathway-therapeutic-approaches-to-disease-prevention
#4
Zhi-Jun Wang, Jian Wu, Wei Guo, Yi-Zhun Zhu
Hydrogen sulfide (H2S) is now admitted as a third gasotransmitter together with nitric oxide (NO) and carbon monoxide (CO), albeit it was originally considered as a foul and poisonous gas. Endogenous H2S production in mammalian cells is counting on the three enzymes acting on cysteine. Involvement of H2S in various physiological and pathological processes has been extensively studied in the last fifteen years. Mounting evidence suggests that H2S is able to protect against atherosclerosis development and progression...
June 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28641269/a-model-based-tool-for-the-analysis-and-design-of-gene-regulatory-network
#5
Liliana Ironi, Ettore Lanzarone
Computational and mathematical models have significantly contributed to the rapid progress in the study of gene regulatory networks (GRN), but researchers still lack a reliable model-based framework for computer-aided analysis and design. Such tool should both reveal the relation between network structure and dynamics and find parameter values and/or constraints that enable the simulated dynamics to reproduce specific behaviors. This paper addresses these issues and proposes a computational framework that facilitates network analysis or design...
June 19, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28641240/placing-sites-on-the-edge-of-planar-silicon-microelectrodes-enhances-chronic-recording-functionality
#6
Heui Chang Lee, Janak Gaire, Badrinath Roysam, Kevin J Otto
OBJECTIVE: This study aims to identify the impact of using edge sites over center sites on a planar silicon microelectrode array. METHODS: We used custom-designed, silicon-substrate multi-site microelectrode arrays with sites on the center, edge, and tip. We compared their single unit recording capability, noise level, impedance, and histology to identify the differences between each site location. Wide and narrow devices were used to evaluate if the differences are consistent and meets theoretical expectations...
June 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28641201/pelvic-and-hip-kinematics-during-single-leg-drop-landing-are-altered-in-sports-participants-with-long-standing-groin-pain-a-cross-sectional-study
#7
L Janse van Rensburg, M Dare, Q Louw, L Crous, J Cockroft, L Williams, B Olivier
OBJECTIVES: The aim of this study was to determine the differences in three-dimensional pelvic and hip kinematics during a single-leg drop-landing task in active sports participants with long-standing groin pain compared to healthy matched controls. DESIGN: This was a descriptive study incorporating a cross-sectional design. SETTING: The study was conducted at the Unit for Human Movement Analysis, Stellenbosch University, South Africa. PARTICIPANTS: The study sample was comprised of 20 male club level soccer, rugby, running and cycling participants between the ages of 18 and 55 years...
May 12, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28641198/combined-computational-experimental-approach-to-predict-blood-brain-barrier-bbb-permeation-based-on-green-salting-out-thin-layer-chromatography-supported-by-simple-molecular-descriptors
#8
Krzesimir Ciura, Mariusz Belka, Piotr Kawczak, Tomasz Bączek, Michał J Markuszewski, Joanna Nowakowska
The objective of this paper is to build QSRR/QSAR model for predicting the blood-brain barrier (BBB) permeability. The obtained models are based on salting-out thin layer chromatography (SOTLC) constants and calculated molecular descriptors. Among chromatographic methods SOTLC was chosen, since the mobile phases are free of organic solvent. As consequences, there are less toxic, and have lower environmental impact compared to classical reserved phases liquid chromatography (RPLC). During the study three stationary phase silica gel, cellulose plates and neutral aluminum oxide were examined...
June 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28641169/association-between-switching-antiepileptic-drug-products-and-healthcare-utilization-a-systematic-review
#9
REVIEW
Patrick Kwan, André Palmini
AIMS: There is ongoing concern whether switching between different antiepileptic drug (AED) products may compromise patient care. We systematically reviewed changes in healthcare utilization following AED switch. METHODS: We searched MEDLINE and EMBASE databases (1980-October 2016) for studies that assessed the effect of AED switching in patients with epilepsy on outpatient visits, emergency room visits, hospitalization and hospital stay duration. RESULTS: A total of 14 articles met the inclusion criteria...
June 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28641157/design-synthesis-and-structure-activity-relationship-studies-of-a-novel-focused-library-of-2-3-4-substituted-oxazolidines-with-antiproliferative-activity-against-cancer-cell-lines
#10
Saulo F Andrade, Bárbara G Oliveira, Larissa C Pereira, Jonas P Ramos, Angélica R Joaquim, Martin Steppe, Elaine M Souza-Fagundes, Ricardo J Alves
In the present work we describe the synthesis and antiproliferative evaluation of a focused library of 30 novel oxazolidines designed by modification of N-substituent, by ring variation, by alkyl variation or by extension of the structure. It was noted that carbamate and N,O-aminal groups were essential for activity. In general, replacement of the phenyl ring with pyridinyl was not tolerated. However, the introduction of a second phenyl ring with an appropriate spacer at the 3- or 4-position of the first phenyl ring generally enhanced the cytotoxic profile...
June 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28641149/thyroid-autoimmunity-in-bipolar-disorder-a-systematic-review
#11
REVIEW
Margherita Barbuti, André F Carvalho, Cristiano A Köhler, Andrea Murru, Norma Verdolini, Giovanni Guiso, Ludovic Samalin, Michael Maes, Brendon Stubbs, Giulio Perugi, Eduard Vieta, Isabella Pacchiarotti
BACKGROUND: Accumulating evidence points to the pathophysiological relevance between immune dysfunction and mood disorders. High rates of thyroid dysfunction have been found in patients with bipolar disorder (BD), compared to the general population. A systematic review of the relationship between BD and thyroid autoimmunity was performed. METHODS: Pubmed, EMBASE and PsycINFO databases were searched up till January 28th, 2017. This review has been conducted according to the PRISMA statements...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28641147/suicidal-thoughts-and-behaviors-among-women-firefighters-an-examination-of-associated-features-and-comparison-of-pre-career-and-career-prevalence-rates
#12
Ian H Stanley, Melanie A Hom, Sally Spencer-Thomas, Thomas E Joiner
BACKGROUND: Women protective service workers die by suicide at a higher rate than women workers in other occupational groups. However, no study has examined rates and correlates of suicidal thoughts and behaviors among women firefighters, despite the potential for these data to inform suicide screening, prevention, and intervention initiatives. The purpose of this study is to describe and compare pre-career and career rates of suicidal thoughts and behaviors and identify their sociodemographic and occupational correlates among women firefighters...
June 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28641146/early-development-and-predictors-of-morphological-awareness-disentangling-the-impact-of-decoding-skills-and-phonological-awareness
#13
Jeremy M Law, Pol Ghesquière
BACKGROUND: Morphological Awareness (MA) has been demonstrated to be influential on the reading outcomes of children and adults. Yet, little is known regarding MA's early development. AIM: The aim of this study is to better understand MA at different stages of development and its association with Phonological Awareness (PA) and reading. METHODS AND PROCEDURES: In a longitudinal design the development of MA was explored in a group of pre-reading children with a family risk of dyslexia and age-matched controls from kindergarten up to and including grade 2...
June 19, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28641132/heritability-of-lifetime-ecstasy-use
#14
Karin J H Verweij, Jorien L Treur, Annabel Vreeker, Tibor M Brunt, Gonneke Willemsen, Dorret I Boomsma, Jacqueline M Vink
BACKGROUND: Ecstasy is a widely used psychoactive drug that users often take because they experience positive effects such as increased euphoria, sociability, elevated mood, and heightened sensations. Ecstasy use is not harmless and several immediate and long term side effects have been identified. Lifetime ecstasy use is likely to be partly influenced by genetic factors, but no twin study has determined the heritability. Here, we apply a classical twin design to a large sample of twins and siblings to estimate the heritability of lifetime ecstasy use...
June 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28641128/expectancy-of-impairment-attenuates-marijuana-induced-risk-taking
#15
Rachel L Gunn, Linda Skalski, Jane Metrik
BACKGROUND: Marijuana use has been associated with increased risk-taking and impulsive behavior. While pharmacologic effects of marijuana can lead to inhibitory impairment, expectancy of potential impairment may result in compensatory behavioral response by decreasing impulsive decisions and risky behaviors. With the increases in marijuana use and related problems, a better understanding of the individual characteristics associated with marijuana intoxication and risky behavior is needed...
June 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28641121/is-inhibitory-control-involved-in-discriminating-pseudowords-that-contain-the-reversible-letters-b-and-d
#16
Lorie-Marlène Brault Foisy, Emmanuel Ahr, Steve Masson, Olivier Houdé, Grégoire Borst
Children tend to confuse reversible letters such as b and d when they start learning to read. According to some authors, mirror errors are a consequence of the mirror generalization (MG) process that allows one to recognize objects independently of their left-right orientation. Although MG is advantageous for the visual recognition of objects, it is detrimental for the visual recognition of reversible letters. Previous studies comparing novice and expert readers demonstrated that MG must be inhibited to discriminate reversible single letters...
June 19, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28641068/centric-relation-intercuspal-position-discrepancy-and-its-relationship-with-temporomandibular-disorders-a-systematic-review
#17
Antonio Jiménez-Silva, Julio Tobar-Reyes, Sheilah Vivanco-Coke, Eduardo Pastén-Castro, Hernán Palomino-Montenegro
OBJECTIVE: The objective of this study is to assess the relationship between centric relation-intercuspal position discrepancy (CR-ICP discrepancy) and temporomandibular disorders (TMDs), by systematically reviewing the literature. MATERIALS AND METHODS: A systematic research was performed between 1960 and 2016 based on electronic databases: PubMed, Cochrane Library, Medline, Embase, Scopus, EBSCOhost, BIREME, Lilacs and Scielo, including all languages. Analytical observational clinical studies were identified...
June 22, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28641062/the-difficulty-of-being-a-professional-a-parent-and-a-spouse-on-the-same-day-daily-spillover-of-workplace-interactions-on-parenting-and-the-role-of-spousal-support
#18
Kaisa Malinen, Anna Rönkä, Eija Sevón, Dominik Schoebi
Designing parenting interventions and preventions requires knowledge on the factors and processes that shape parenting behaviors. Using data collected over 10 days, during the last hour of work and before going to bed, this study examined the spillover of interpersonal work stresses into positive and negative parenting behaviors. Data were collected among 103 couples who had at least one child between the age of one and eight years. Of particular interest was the role of received emotional spousal support as a moderator of stress spillover...
July 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28641044/the-effects-of-short-versus-long-inter-set-rest-intervals-in-resistance-training-on-measures-of-muscle-hypertrophy-a-systematic-review
#19
Jozo Grgic, Bruno Lazinica, Pavle Mikulic, James W Krieger, Brad Jon Schoenfeld
Although the effects of short versus long inter-set rest intervals in resistance training on measures of muscle hypertrophy have been investigated in several studies, the findings are equivocal and the practical implications remain unclear. In an attempt to provide clarity on the topic, we performed a systematic literature search of PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library, and Physiotherapy Evidence Database (PEDro) electronic databases. Six studies were found to have met the inclusion criteria: (a) an experimental trial published in an English-language peer-reviewed journal; (b) the study compared the use of short (≤60 s) to long (>60 s) inter-set rest intervals in a traditional dynamic resistance exercise using both concentric and eccentric muscle actions, with the only difference in resistance training among groups being the inter-set rest interval duration; (c) at least one method of measuring changes in muscle mass was used in the study; (d) the study lasted for a minimum of four weeks, employed a training frequency of ≥2 resistance training days per week, and (e) used human participants without known chronic disease or injury...
June 22, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28641042/resolving-the-melampsora-epitea-complex
#20
Peng Zhao, Makoto Kakishima, Qi Wang, Lei Cai
Melampsora epitea (Pucciniales, Basidiomycota) has been widely known as the main rust pathogen on willows, but its species boundary has been extremely confusing. Melampsora epitea was often confused with several morphologically similar species, such as M. arctica, M. humilis, and M. epiphylla. Recent DNA-based studies using specimens from North America and Europe suggested that M. epitea was a complex of several phylogenetic species. In this study, we examined the species boundary of M. epitea based on rDNA phylogeny and the general mixed Yule coalescent (GMYC) model from 534 specimens...
May 11, 2017: Mycologia
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