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https://www.readbyqxmd.com/read/28103623/metabolic-inflexibility-with-obesity-and-the-effects-of-fenofibrate-on-skeletal-muscle-fatty-acid-oxidation
#1
Kristen E Boyle, Jacob E Friedman, Rachel C Janssen, Chantal Underkofler, Joseph A Houmard, Neda Rasouli
This study was designed to investigate mechanisms of lipid metabolic inflexibility in human obesity and the ability of fenofibrate (FENO) to increase skeletal muscle fatty acid oxidation (FAO) in primary human skeletal muscle cell cultures (HSkMC) exhibiting metabolic inflexibility. HSkMC from 10 lean and 10 obese, insulin resistant subjects were treated with excess fatty acid for 24 h (24hFA) to gauge lipid-related metabolic flexibility. Metabolically inflexible HSkMC from obese individuals were then treated with 24hFA in combination with FENO to determine effectiveness for increasing FAO...
January 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28103597/psychophysiological-effects-of-a-single-short-and-moderately-bright-room-light-exposure-on-mildly-depressed-geriatric-inpatients-a-pilot-study
#2
Markus Canazei, Wilfried Pohl, Kathrin Bauernhofer, Ilona Papousek, Helmut K Lackner, Harald R Bliem, Josef Marksteiner, Elisabeth M Weiss
BACKGROUND: Light interventions typically exert their mood-related effects during morning bright light exposures over several weeks. Evidence about immediate ambient room light effects on depressed individuals is still sparse. OBJECTIVE: The present study aimed at examining the acute effects of a single moderately bright room light exposure on mood, and behavioural and cardiac stress reactions of mildly depressed geriatric inpatients during a short cognitive stimulation and while resting...
January 20, 2017: Gerontology
https://www.readbyqxmd.com/read/28103592/influences-of-various-peptide-linkers-on-the-thermotoga-maritima-msb8-nitrilase-displayed-on-the-spore-surface-of-bacillus-subtilis
#3
Huayou Chen, Zhi Chen, Bangguo Wu, Jawad Ullah, Tianxi Zhang, Jinru Jia, Hongcheng Wang, Tianwei Tan
In the present study, fusion genes composed of Thermotoga maritima MSB8 nitrilase and Bacillus subtilis 168 outer coat protein CotG were constructed with various peptide linkers and displayed on B. subtilis DB 403 spores. The successful display of CotG-nit fusion proteins on the spore surface of B. subtilis was verified by Western blot analysis and activity measurement. It was demonstrated that the fusion with linker GGGGSEAAAKGGGGS presented the highest thermal and pH stability, which is 2.67- and 1.9-fold of the fusion without linker...
January 20, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28103567/predictive-control-of-networked-multiagent-systems-via-cloud-computing
#4
Guo-Ping Liu
This paper studies the design and analysis of networked multiagent predictive control systems via cloud computing. A cloud predictive control scheme for networked multiagent systems (NMASs) is proposed to achieve consensus and stability simultaneously and to compensate for network delays actively. The design of the cloud predictive controller for NMASs is detailed. The analysis of the cloud predictive control scheme gives the necessary and sufficient conditions of stability and consensus of closed-loop networked multiagent control systems...
January 18, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103564/mograms-a-network-based-methodology-for-visualizing-the-set-of-nondominated-solutions-in-multiobjective-optimization
#5
Krzysztof Trawinski, Manuel Chica, David P Pancho, Sergio Damas, Oscar Cordon
An appropriate visualization of multiobjective nondominated solutions is a valuable asset for decision making. Although there are methods for visualizing the solutions in the design space, they do not provide any information about their relationship. In this paper, we propose a novel methodology that allows the visualization of the nondominated solutions in the design space and their relationships by means of a network. The nodes represent the solutions in the objective space while the edges show the relationships among the solutions in the design space...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103537/hybrids-of-thienopyrimidinones-and-thiouracils-as-anti-tubercular-agents-sar-and-docking-studies
#6
Mahesh M Pisal, Laxman U Nawale, Manoj D Patil, Sujit G Bhansali, Jayant M Gajbhiye, Dhiman Sarkar, Subhash P Chavan, Hanumant B Borate
A number of hybrid molecules containing thienopyrimidinones and thiouracil moieties were designed, synthesized and tested against Mycobacterium tuberculosis H37Ra wherein it was observed that the compounds 11-14 exhibited antitubercular activity in vitro (MIC 7.6-19.1 μg/mL, 12-35 μM) against dormant stage while the compound 15 exhibited antitubercular activity in vitro against dormant (MIC 23.4 μg/mL, 41 μM) as well as active (MIC 25.4 μg/mL, 45 μM) stage. Structural modifications of the compound 15 were carried out to study the structure-activity relationship and it was observed that the compound 18 exhibited antitubercular activity comparable to the compound 15...
January 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28103529/improving-osteogenesis-of-three-dimensional-porous-scaffold-based-on-mineralized-recombinant-human-like-collagen-via-mussel-inspired-polydopamine-and-effective-immobilization-of-bmp-2-derived-peptide
#7
Jing Zhou, Xiaodong Guo, Qixin Zheng, Yongchao Wu, Fuzai Cui, Bin Wu
An ideal bone substitute should be biocompatible, biodegradable, osteoinductive and osteoconductive. In our previous work, we fabricated a three-dimensional porous scaffold based on mineralized recombinant human-like collagen, nano-hydroxyapatite/recombinant human-like collagen/poly(lactic acid) (nHA/RHLC/PLA). Like other HA/collagen scaffolds, the nHA/RHLC/PLA scaffold lacked osteoinductive bioactivity. The purpose of the present study was to develop a polydopamine (pDA)-assisted BMP-2-derived peptide (designated as P24) surface modification strategy for improving the osteogenesis of the nHA/RHLC/PLA scaffold...
January 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28103524/validation-of-a-bicycle-simulator-for-road-safety-research
#8
Steve O'Hern, Jennie Oxley, Mark Stevenson
The study's aim was to assess the behavioural validity of participants using of a newly developed bicycle simulator with respect to a range of cycling performance measures collected both using the cycling simulator and on-road. The validation study consisted of a within-subjects study design comparing participants riding on-road with riding in the simulator. The study recruited 26 participants ranging in age from 18 to 35 years (M=25.0, SD=4.8). Absolute validity was established for measures of spatial positioning including average lane position, deviation in lane position and average passing distance from kerbside parked cars...
January 16, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28103456/health-inequalities-in-diabetes-mellitus-and-hypertension-a-parish-level-study-in-the-northern-region-of-portugal
#9
Teresa Leao, Julian Perelman, Manuela Felício, Vasco Machado, Graça Lima
INTRODUCTION: Diabetes and hypertension are highly prevalent conditions in Portugal. Little is known about the geographical and social patterning of these diseases, which precludes the design of targeted health policies. This study aimed to measure the geographical and socioeconomic distribution of type 2 diabetes and hypertension prevalence in the population resident in the Northern region of Portugal, for the year 2013. MATERIAL AND METHODS: An ecological correlation study analyzed the 2,028 parishes of the region...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103438/acylguanidine-beta-secretase-1-inhibitors-a-combined-experimental-and-free-energy-perturbation-study
#10
Henrik Keränen, Laura Pérez-Benito, Myriam Ciordia, Francisca Delgado, Thomas B Steinbrecher, Daniel Oehlrich, Herman W T Van Vlijmen, Andrés A Trabanco, Gary Tresadern
A series of acylguanidine beta secretase 1 (BACE1) inhibitors with modified scaffold and P3 pocket substituent was synthesized and studied with Free Energy Perturbation (FEP) calculations. The resulting molecules showed potencies in enzymatic BACE1 inhibition assays up to 1 nM. The correlation between the predicted activity from the FEP calculations and the experimental activity was good for the P3 pocket substituents. The average mean unsigned error (MUE) between prediction and experiment was 0.68 ± 0.17 kcal/mol for the default 5 ns lambda window simulation time improving to 0...
January 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28103415/predictors-of-ptsd-symptom-change-among-outpatients-in-the-u-s-department-of-veterans-affairs-health-care-system
#11
Rebecca K Sripada, Paul N Pfeiffer, Jessica Rampton, Dara Ganoczy, Sheila A M Rauch, Melissa A Polusny, Kipling M Bohnert
Although the U.S. Department of Veterans Affairs (VA) has prioritized care for posttraumatic stress disorder (PTSD), many patients with PTSD remain symptomatic. Patterns of PTSD symptom change are not well understood. Thus, the current study was designed to categorize and investigate potential predictors of symptom trajectories in patients with PTSD. The sample comprised 2,237 VA patients who were diagnosed with PTSD in 2013 and completed at least 4 PTSD Checklist (PCL) assessments over 12 weeks. Latent trajectory analysis was used to identify latent classes of patients based on PCL scores...
January 19, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28103394/measuring-patient-engagement-which-health-care-engagement-behaviors-are-important-to-patients
#12
Huey-Ming Tzeng, James Marcus Pierson
AIM(S): This study identified patient health care engagement behaviors that are important to community-dwelling adult patients living in the southern region of the USA. BACKGROUND: Patient engagement has been identified as a key driver for containing health care costs, but the public and health care professionals lack a scientific understanding of patient engagement. A valid tool is needed for prompting patients to discuss health activities with their health care providers and to obtain support...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28103312/increased-cardiovascular-events-and-subclinical-atherosclerosis-in-rheumatoid-arthritis-patients-1-year-prospective-single-centre-study
#13
Piero Ruscitti, Paola Cipriani, Francesco Masedu, Silvio Romano, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Di Benedetto, Saverio Alvaro, Maria Penco, Marco Valenti, Roberto Giacomelli
OBJECTIVES: Several studies showed the close relationship between Rheumatoid Arthritis (RA) and cerebro-cardiovascular events (CVEs) and subclinical atherosclerosis. In this study, we investigated the occurrence of CVEs and subclinical atherosclerosis during the course of RA and we evaluated the possible role of both traditional cardiovascular (CV) and disease related risk factors to predict the occurrence of new CVEs and the onset of subclinical atherosclerosis. METHODS: We designed a single centre, bias-adjusted, prospective, observational study to investigate, in a homogeneous subset of RA patients, the occurrence of new onset of CVEs and subclinical atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28103303/driving-with-intuition-a-preregistered-study-about-the-eeg-anticipation-of-simulated-random-car-accidents
#14
Gian Marco Duma, Giovanni Mento, Tommaso Manari, Massimiliano Martinelli, Patrizio Tressoldi
The study of neural pre-stimulus or "anticipatory" activity opened a new window for understanding how the brain actively constructs the forthcoming reality. Usually, experimental paradigms designed to study anticipatory activity make use of stimuli. The purpose of the present study is to expand the study of neural anticipatory activity upon the temporal occurrence of dichotomic, statistically unpredictable (random) stimuli within an ecological experimental paradigm. To this purpose, we used a simplified driving simulation including two possible, randomly-presented trial types: a car crash end trial and a no car crash end trial...
2017: PloS One
https://www.readbyqxmd.com/read/28103299/walking-through-apertures-in-individuals-with-stroke
#15
Daisuke Muroi, Yasuhiro Hiroi, Teruaki Koshiba, Yohei Suzuki, Masahiro Kawaki, Takahiro Higuchi
OBJECTIVE: Walking through a narrow aperture requires unique postural configurations, i.e., body rotation in the yaw dimension. Stroke individuals may have difficulty performing the body rotations due to motor paralysis on one side of their body. The present study was therefore designed to investigate how successfully such individuals walk through apertures and how they perform body rotation behavior. METHOD: Stroke fallers (n = 10), stroke non-fallers (n = 13), and healthy controls (n = 23) participated...
2017: PloS One
https://www.readbyqxmd.com/read/28103251/active-hydrogen-bond-network-ahbn-and-applications-for-improvement-of-thermal-stability-and-ph-sensitivity-of-pullulanase-from-bacillus-naganoensis
#16
Qing-Yan Wang, Neng-Zhong Xie, Qi-Shi Du, Yan Qin, Jian-Xiu Li, Jian-Zong Meng, Ri-Bo Huang
A method, so called "active hydrogen bond network" (AHBN), is proposed for site-directed mutations of hydrolytic enzymes. In an enzyme the AHBN consists of the active residues, functional residues, and conservative water molecules, which are connected by hydrogen bonds, forming a three dimensional network. In the catalysis hydrolytic reactions of hydrolytic enzymes AHBN is responsible for the transportation of protons and water molecules, and maintaining the active and dynamic structures of enzymes. The AHBN of pullulanase BNPulA324 from Bacillus naganoensis was constructed based on a homologous model structure using Swiss Model Protein-modeling Server according to the template structure of pullulanase BAPulA (2WAN)...
2017: PloS One
https://www.readbyqxmd.com/read/28103246/joint-optimization-of-distribution-network-design-and-two-echelon-inventory-control-with-stochastic-demand-and-co2-emission-tax-charges
#17
Shuangyan Li, Xialian Li, Dezhi Zhang, Lingyun Zhou
This study develops an optimization model to integrate facility location and inventory control for a three-level distribution network consisting of a supplier, multiple distribution centers (DCs), and multiple retailers. The integrated model addressed in this study simultaneously determines three types of decisions: (1) facility location (optimal number, location, and size of DCs); (2) allocation (assignment of suppliers to located DCs and retailers to located DCs, and corresponding optimal transport mode choices); and (3) inventory control decisions on order quantities, reorder points, and amount of safety stock at each retailer and opened DC...
2017: PloS One
https://www.readbyqxmd.com/read/28103232/a-model-of-compound-heterozygous-loss-of-function-alleles-is-broadly-consistent-with-observations-from-complex-disease-gwas-datasets
#18
Jaleal S Sanjak, Anthony D Long, Kevin R Thornton
The genetic component of complex disease risk in humans remains largely unexplained. A corollary is that the allelic spectrum of genetic variants contributing to complex disease risk is unknown. Theoretical models that relate population genetic processes to the maintenance of genetic variation for quantitative traits may suggest profitable avenues for future experimental design. Here we use forward simulation to model a genomic region evolving under a balance between recurrent deleterious mutation and Gaussian stabilizing selection...
January 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28103179/theory-based-formative-research-on-an-anti-cyberbullying-victimization-intervention-message
#19
Matthew W Savage, Douglas M Deiss, Anthony J Roberto, Elias Aboujaoude
Cyberbullying is a common byproduct of the digital revolution with serious consequences to victims. Unfortunately, there is a dearth of empirically based methods to confront it. This study used social cognitive theory to design and test an intervention message aimed at persuading college students to abstain from retaliation, seek social support, save evidence, and notify authorities-important victim responses identified and recommended in previous research. Using a posttest-only control group design, this study tested the effectiveness of an intervention message in changing college students' perceived susceptibility to and perceived severity of cyberbullying as well as their self-efficacy, response efficacy, attitudes, and behavioral intentions toward each recommended response in future episodes of cyberbullying...
January 19, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28103177/hbxip-a-binding-protein-of-hbx-regulates-maintenance-of-the-g2-m-phase-checkpoint-induced-by-dna-damage-and-enhances-sensitivity-to-doxorubicin-induced-cytotoxicity
#20
Hong-Rong Fei, Yun-Sheng Zhou, Ruo-Tong Li, Ming-Feng Yang, Jian Ma, Feng-Ze Wang
To maintain the integrity of the genome, cells need to detect and repair DNA damage before they complete cell division. Hepatitis B x-interacting protein (HBXIP), a binding protein of HBx (Hepatitis B virus x protein), is aberrantly overexpressed in human cancer cells and show to promote cell proliferation and inhibit apoptosis. The present study is designed to investigate the role of HBXIP on the DNA damage response. Our results show that HBXIP acts as an important regulator of G2/M checkpoint in response to DNA damage...
January 19, 2017: Cell Cycle
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