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https://www.readbyqxmd.com/read/28214679/estradiol-is-a-critical-regulator-of-food-reward-behavior
#1
Jennifer E Richard, Lorena López-Ferreras, Rozita H Anderberg, Kajsa Olandersson, Karolina P Skibicka
Food intake is reduced by estrogenic hormones, levels of which vary throughout life and fluctuate throughout the ovarian cycle in females. However, estrogens have also been shown to increase reward derived from drugs of abuse, where motivational properties of drugs and progression to addiction are potentiated by estrogens. Whether reward derived from food, and specifically motivational properties of food, are altered by estrogens remains unknown. Here we investigated the effect of the estrous cycle on food reward behavior and show estrous cycle dictated variability in food motivation, measured by progressive ratio operant conditioning, in female rats...
January 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28212612/african-ancestry-is-associated-with-facial-melasma-in-women-a-cross-sectional-study
#2
Maria Paula Barbieri D'Elia, Marcela Calixto Brandão, Bruna Ribeiro de Andrade Ramos, Márcia Guimarães da Silva, Luciane Donida Bartoli Miot, Sidney Emanuel Batista Dos Santos, Hélio Amante Miot
BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma. METHODS: A cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed...
February 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28212122/a-research-of-soft-tissue-lipoma-genesis-factor-with-immunohistochemical-analysis
#3
Jun Beom Lee, Hwan Jun Choi, Eun Taik Son, Jun Hyuk Kim
INTRODUCTION: Lipoma is the most familiar soft-tissue tumor. But the etiology of lipoma remains imprecise. Sex steroid hormones such as estrogen have effects on muscle and adipose tissue development. There is now significant evidence that sex steroids are involved in the site specificities of adipose tissue metabolism. This association of adipose tissue metabolism between sex steroid hormones suggests a possible role for sex steroids in the pathogenesis of lipoma. METHODS: To investigate this concept, the authors evaluated the expression of the estrogen receptor (ER) and the progesterone receptor (PR) in soft tissue lipoma in this study...
February 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28209578/intraforaminal-location-of-thoracolumbar-radicular-arteries-providing-an-anterior-radiculomedullary-artery-using-flat-panel-catheter-angiotomography
#4
L Gregg, D E Sorte, P Gailloud
BACKGROUND AND PURPOSE: Flat panel catheter angiotomography performed during the selective injection of intersegmental arteries offers a multiplanar assessment of the intraforaminal course of the radicular arteries providing an anterior radiculomedullary artery. Injury of anterior radiculomedullary arteries during transforaminal epidural steroid injections can result in spinal cord damage. Evaluations of the intraforaminal location of these arteries have so far been limited to anteroposterior views or the examination of cadaveric material...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28197868/plasma-levels-of-immune-factors-and-sex-steroids-in-the-male-seahorse-hippocampus-erectus-during-a-breeding-cycle
#5
Tingting Lin, Xin Liu, Dongxue Xiao, Dong Zhang
To better understand the endocrine- and immune-response pattern during reproduction in a fish species having parental care behaviors and also to accumulate the endocrine- and immune-related data for future explanations of the low reproductive efficiency in seahorse species, the variations of immune factors and sex steroids in the plasma of the male lined seahorse Hippocampus erectus at different breeding stages, i.e., pre-pregnancy, pregnancy (early, middle, and late periods), and post-pregnancy, were investigated in the present study...
February 14, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28196668/effects-of-sex-hormone-treatment-on-white-matter-microstructure-in-individuals-with-gender-dysphoria
#6
Georg S Kranz, Rene Seiger, Ulrike Kaufmann, Allan Hummer, Andreas Hahn, Sebastian Ganger, Martin Tik, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger
Sex steroid hormones such as estradiol and testosterone are known to have organizing, as well as activating effects on neural tissue in animals and humans. This study investigated the effects of transgender hormone replacement therapy on white matter microstructure using diffusion tensor imaging. Female-to-male and male-to-female transgender participants were measured at baseline, four weeks and four months past treatment start and compared to female and male controls. We observed androgenization-related reductions in mean diffusivity and increases in fractional anisotropy...
February 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28190856/virilism-and-ectopic-expression-of-hsd17b5-in-mature-cystic-teratoma
#7
Yohei Kawaguchi, Hiroko Mizuno, Mai Horikawa, Mayuko Kano, Kengo Yamada, Fumiko Yamakawa, Takashi Maekawa, Yuto Yamazaki, Keely M McNamara, Hironobu Sasano, Masayuki Hayashi
Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28189029/disruption-of-thyroxine-and-sex-hormones-by-1-2-dibromo-4-1-2-dibromoethyl-cyclohexane-dbe-dbch-in-american-kestrels-falco-sparverius-and-associations-with-reproductive-and-behavioral-changes
#8
Sarah C Marteinson, Vince Palace, Robert J Letcher, Kim J Fernie
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (DBE-DBCH - formerly TBECH) is an emerging brominated flame retardant (BFR) pollutant with androgen potentiating ability and other endocrine disrupting effects in birds and fish. The objectives of this study were to determine the effects of exposure to environmentally-relevant levels of DBE-DBCH on circulating levels of thyroid and sex steroid hormones in American kestrels, and if hormonal concentrations were related to previously reported changes in reproductive success and courtship behaviors...
February 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28188743/primary-males-guide-the-femaleness-through-the-regulation-of-testicular-dmrt1-and-ovarian-cyp19a1a-in-protandrous-black-porgy
#9
REVIEW
Guan-Chung Wu, Ching-Fong Chang
Controlling the development of the sexes is critically important for the broodstock management in aquaculture. Sex steroids are widely used for sex control of fish. However, hermaphroditic fish have a plastic sex, and a stable sex is difficult to maintain with sex steroids. We used the black porgy (Acanthopagrus schlegelii) as a model to understand the possible mechanism of sexual fate decision. Low exogenous estradiol (E2) induced male development. In contrast, high exogenous E2 induced the regression of the testis and the development of the ovary and resulted in an unstable expression of femaleness (passive femaleness, with ovaries containing only the primary oocytes)...
February 7, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28188242/diagnosis-of-endocrine-disease-steroid-hormone-analysis-in-diagnosis-and-treatment-of-dsd-position-paper-of-eu-cost-action-bm-1303-dsdnet
#10
Alexandra Kulle, Nils Krone, Paul-Martin Holterhus, Gerhard Schuler, Ronda Greaves, Anders Juul, Yolanda de Rijke, Michaela Hartmann, Alessandro Saba, Olaf Hiort, Stefan Wudy
Disorders or differences in sex development (DSD) comprise a heterogeneous group of conditions with an atypical sex development. For optimal diagnosis highly specialized laboratory analyses are required across European countries. Working group 3 of EU COST (European Cooperation in Science and Technology) Action BM 1303 "DSDnet" "Harmonisation of Laboratory Assessment" has developed recommendations on laboratory assessment for DSD regarding the use of technologies and analytes to be investigated. This position paper on steroid hormone analysis in diagnosis and treatment of DSD was compiled by a group of specialists in DSD and/or hormonal analysis, either from participating European Countries or international partner countries...
February 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28185934/corticosteroids-deeply-depress-the-in-vitro-steroidogenic-capacity-of-eurasian-perch-ovary-at-the-end-of-the-reproductive-cycle
#11
S N M Mandiki, S Milla, S Nkogo Robles, P Kestemont
Corticosteroids play positive or negative role in the reproductive mechanisms of many fish species but the physiological contexts relating to such biphasic actions are not well defined. In the present study we investigated to what extent corticosteroids (cortisol-Co, 11-deoxycorticosterone-DOC) hormones may interfere with the steroidogenic capacity of Eurasian perch follicles, and we tested whether the negative interference of corticosteroids may be mitigated by potential stimulating endocrine factors, namely insulin-like growth factor-1 (IGF), human chorionic gonadotropin (HCG) or thyroid hormones (Triidothyronine-T3, thyroxine-T4)...
February 6, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28181933/severe-intraoperative-hyperglycemia-is-independently-associated-with-postoperative-composite-infection-after-craniotomy-an-observational-study
#12
Shaun E Gruenbaum, Laura Toscani, Kenneth M Fomberstein, Keith J Ruskin, Feng Dai, Ega Qeva, Giovanni Rosa, Lingzhong Meng, Federico Bilotta
BACKGROUND: Postoperative infection after craniotomy carries an increased risk of morbidity and mortality. Identification and correction of the risk factors should be prioritized. The association of intraoperative hyperglycemia with postoperative infections in patients undergoing craniotomy is inadequately studied. METHODS: A total of 224 patients were prospectively enrolled in 2 major medical centers to assess whether severe intraoperative hyperglycemia (SIH, blood glucose ≥180 mg/dL) is associated with an increased risk of postoperative infection in patients undergoing craniotomy...
February 8, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28178878/disease-characterization-of-systemic-lupus-erythematosus-sle-patients-in-quebec
#13
R Ng, S Bernatsky, E Rahme
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an array of organ manifestations that can appear during flares and disappear during remissions. The objectives of this study were: (i) to examine SLE manifestation groups longitudinally in an SLE cohort; and (ii) to assess the association between early antimalarial treatment and renal manifestations. Methods Seven SLE manifestation groups-cutaneous, hematologic, lung, musculoskeletal, neuropsychiatric, serositis, renal-were tracked using Kaplan-Meier survival curves in an incident SLE cohort from Quebec health administrative data ( n = 2010)...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28176955/urinary-excretion-of-il-1%C3%AE-il-6-and-il-8-cytokines-during-relapse-and-remission-of-idiopathic-nephrotic-syndrome
#14
Amal A Al-Eisa, Maysoun Al Rushood, Rajaa J Al-Attiyah
BACKGROUND/AIM: The role of pro-inflammatory cytokines in the immunopathogenesis of idiopathic nephrotic syndrome had been widely postulated. Reports on the release of cytokines, during idiopathic nephrotic syndrome (INS) activation, were conflicting in defining a specific interleukin pattern during relapse and remission of the disease. The aim of this study was to explore the role of IL-1β, IL-6 and IL-8 in the pathophysiology of INS during relapse and remission. PATIENTS AND METHODS: A total of 37 INS patients were included...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28168997/icv-galanin-like-peptide-stimulates-non-contact-erections-but-not-touch-based-erections-in-adult-sexually-experienced-male-rats
#15
Gregory S Fraley
Galanin-like peptide (GALP) is a neuropeptide transcribed only within the arcuate nucleus of the hypothalamus and is thought to be a mediator between energetics and reproductive function. Intracerebroventricular (ICV) injection of GALP is known to have effects on feeding, and to significantly increase gonadotropin releasing hormone- (GnRH-) mediated luteinizing hormone (LH) secretion. Furthermore, ICV GALP is known to stimulate fos production in the medial pre-optic area (mPOA) and to a lesser extent, the paraventricular nucleus (PVN)...
January 23, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28167850/hip-osteonecrosis-is-associated-with-increased-plasma-il-33-level
#16
Jinhui Ma, Wanshou Guo, Zirong Li, Bailiang Wang, Shirui Li, Peng Wang
The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass index- (BMI-) matched healthy subjects were included in this prospective study between March 2016 and September 2016. A commercially available ELISA kit was used to test the level of plasma IL-33...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28164356/nationwide-surveys-show-that-the-incidence-of-recurrent-kawasaki-disease-in-japan-has-hardly-changed-over-the-last-30-years
#17
D Sudo, Y Nakamura
AIM: Since Kawasaki disease (KD) was first reported in 1967, its aetiology has been intensively investigated, but remains unclear. We investigated the incidence of recurrent KD in Japan in 2003-2012, compared to previous data from our team, and assessed the potential risk factors for disease recurrence. METHODS: Data from nationwide KD surveys were retrospectively analysed and 81,310 patients were observed. Incidence rates were compared between different years. RESULTS: The incidence rates for recurrent KD were 3...
February 5, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28156624/a-study-of-discrepancy-between-laboratory-calculated-and-weight-based-glomerular-filtration-rate-gfr-as-a-marker-of-renal-function-in-a-palliative-care-population
#18
Miriam Colleran
: 58 Background: Renal function is important in a palliative care population and can impact on frequently-used medications including chemotherapeutic agents, opioids, non-steroidal anti-inflammatory drugs and neuropathic agents. In local practice, estimated glomerular filtration rate (eGFR), calculated on a presumed weight of 70kg, is displayed in laboratory results. However, the weight of palliative patients varies considerably, for example, due to cancer cachexia or malabsorption and a considerable population weigh less than 70kg...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154777/bcl-2-expression-is-a-poor-predictor-for-hepatocellular-carcinoma-prognosis-of-andropause-age-patients
#19
Xiao-Fei Zhang, Xin Yang, Hu-Liang Jia, Wen-Wei Zhu, Lu Lu, Wei Shi, Hao Zhang, Jin-Hong Chen, Yi-Feng Tao, Zheng-Xin Wang, Jun Yang, Lian-Xin Wang, Ming Lu, Yan Zheng, Jing Zhao, Qiong-Zhu Dong, Lun-Xiu Qin
OBJECTIVE: The expression of B-cell lymphoma 2 (Bcl-2) seems to be influenced by the endocrine environment. Numerous reports demonstrate the diverse expression of Bcl-2 family members under sex steroid regulation. With the exception of estrogen-related tumors, androgen-related tumors have shown their characteristics in Bcl-2 expression. In this study, the status of Bcl-2 expression in male hepatocellular carcinoma (HCC) patients was examined to verify the high incidence of HCC in males...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28153489/androgens-in-women-are-essentially-made-from-dhea-in-each-peripheral-tissue-according-to-intracrinology
#20
REVIEW
Fernand Labrie, Céline Martel, Alain Bélanger, Georges Pelletier
The objective is to review how the cell-specific amounts of intracellular androgens are all made in women from circulating dehydroepiandrosterone (DHEA) in each peripheral tissue, independently from the rest of the body. Following 500 million years of evolution, approximately three dozen cell-specific intracrine enzymes have been engineered in human peripheral tissues whereby the inactive sex steroid precursor DHEA mainly of adrenal origin is transformed into the appropriate minute intracellular amounts of androgens...
January 30, 2017: Journal of Steroid Biochemistry and Molecular Biology
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