keyword
MENU ▼
Read by QxMD icon Read
search

Sex steroids

keyword
https://www.readbyqxmd.com/read/29454903/estrogen-receptor-alpha-isoforms-are-the-main-estrogen-receptors-expressed-in-non-small-cell-lung-carcinoma
#1
Vasiliki Pelekanou, Eleftheria Anastasiou, Efstathia Bakogeorgou, George Notas, Marilena Kampa, Rolando Garcia-Milian, Katerina Lavredaki, Eleni Moustou, Georgia Chinari, Petroula Arapantoni, Anthony O'Grady, Vassilios Georgoulias, Andreas Tsapis, Efstathios N Stathopoulos, Elias Castanas
The expression profile of estrogen receptors (ER) in Non-Small Cell Lung Carcinoma (NSCLC) remains contradictory. Here we investigated protein and transcriptome expression of ERα wild type and variants. Tissue Micro-Arrays of 200 cases of NSCLC (paired tumor/non-tumor) were assayed by immunohistochemistry using a panel of ERα antibodies targeting different epitopes (HC20, 6F11, 1D5, ERα36 and ERα17p). ERβ epitopes were also examined for comparison. In parallel we conducted a probe-set mapping (Affymetrix HGU133 plus 2 chip) meta-analysis of 12 NSCLC tumor public transcriptomic studies (1418 cases) and 39 NSCLC cell lines...
February 15, 2018: Steroids
https://www.readbyqxmd.com/read/29454282/contaminants-of-emerging-concern-presence-and-adverse-effects-in-fish-a-case-study-in-the-laurentian-great-lakes
#2
Zachary G Jorgenson, Linnea M Thomas, Sarah M Elliott, Jenna E Cavallin, Eric C Randolph, Steven J Choy, David A Alvarez, Jo A Banda, Daniel J Gefell, Kathy E Lee, Edward T Furlong, Heiko L Schoenfuss
The Laurentian Great Lakes are a valuable natural resource that is affected by contaminants of emerging concern (CECs), including sex steroid hormones, personal care products, pharmaceuticals, industrial chemicals, and new generation pesticides. However, little is known about the fate and biological effects of CECs in tributaries to the Great Lakes. In the current study, 16 sites on three rivers in the Great Lakes basin (Fox, Cuyahoga, and Raquette Rivers) were assessed for CEC presence using polar organic chemical integrative samplers (POCIS) and grab water samplers...
February 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29452853/the-impact-of-sex-steroid-agonists-and-antagonists-on-folliculogenesis-in-the-neonatal-porcine-ovary-via-cell-proliferation-and-apoptosis
#3
Katarzyna Knapczyk-Stwora, Malgorzata Grzesiak, Renata E Ciereszko, Elzbieta Czaja, Marek Koziorowski, Maria Slomczynska
The objective of the study was to examine the effects of androgen and estrogen agonists or antagonists on the follicle formation, ovarian cell proliferation and apoptosis as well as plasma steroid concentration in neonatal pigs. Piglets were injected with testosterone propionate (TP, 20 mg/kg bw), flutamide (FLU, 50 mg/kg bw), 4-tert-octylphenol (OP, 100 mg/kg bw), ICI 182,780 (ICI, 400 μg/kg bw), methoxychlor (MXC, 100 mg/kg bw) or corn oil (CTR, controls) between postnatal Days 1 and 10 (n = 4/group). Heart blood was collected and ovaries were excised from the 11-day-old piglets...
February 10, 2018: Theriogenology
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#4
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29450697/endogenous-sex-steroids-dampen-neuroinflammation-and-improve-outcome-of-traumatic-brain-injury-in-mice
#5
Amy C Clevenger, Hoon Kim, Ernesto Salcedo, Joan C Yonchek, Krista M Rodgers, James E Orfila, Robert M Dietz, Nidia Quillinan, Richard J Traystman, Paco S Herson
The role of biological sex in short-term and long-term outcome after traumatic brain injury (TBI) remains controversial. The observation that exogenous female sex steroids (progesterone and estrogen) reduce brain injury coupled with a small number of clinical studies showing smaller injury in women suggest that sex steroids may play a role in outcome from TBI. We used the controlled cortical impact (CCI) model of TBI in mice to test the hypothesis that after CCI, female mice would demonstrate less injury than male mice, related to the protective role of endogenous steroids...
February 15, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29447494/high-dose-vitamin-d-supplementation-can-improve-menstrual-problems-dysmenorrhea-and-premenstrual-syndrome-in-adolescents
#6
Afsane Bahrami, Amir Avan, Hamid Reza Sadeghnia, Habibollah Esmaeili, Maryam Tayefi, Faezeh Ghasemi, Fatemeh Nejati Salehkhani, Mahla Arabpour-Dahoue, Azam Rastgar-Moghadam, Gordon A Ferns, Hamidreza Bahrami-Taghanaki, Majid Ghayour-Mobarhan
Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received nine high-dose vitamin D supplements (as 50,000 IU/week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in four categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects...
February 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29445914/interaction-between-dietary-acrylamide-intake-and-genetic-variants-for-estrogen-receptor-positive-breast-cancer-risk
#7
Janneke G F Hogervorst, Piet A van den Brandt, Roger W L Godschalk, Frederik-Jan van Schooten, Leo J Schouten
PURPOSE: The association between dietary acrylamide intake and estrogen receptor-positive (ER+) breast cancer risk in epidemiological studies is inconsistent. By analyzing gene-acrylamide interactions for ER+ breast cancer risk, we aimed to clarify the role of acrylamide intake in ER+ breast cancer etiology. METHODS: The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline, a random subcohort of 2589 women was sampled from the total cohort for a case-cohort analysis approach...
February 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29441042/intrinsic-and-extrinsic-thymic-adrenergic-networks-sex-steroid-dependent-plasticity
#8
REVIEW
Gordana Momčilo Leposavić, Ivan M Pilipović
The thymus is sexually differentiated organ providing microenvironment for T-cell precursor differentiation/maturation in the major histocompatibility complex-restricted self-tolerant T cells. With increasing age, the thymus undergoes involution leading to the decline in efficacy of thymopoiesis. Noradrenaline from thymic nerve fibers and "(nor)adrenergic" cells is involved in the regulation of thymopoiesis. In rodents, noradrenaline concentration in thymus and adrenoceptor (AR) expression on thymic cells depend on sex and age...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29439271/normative-basal-values-of-hormones-and-proteins-of-gonadal-and-adrenal-functions-from-birth-to-adulthood
#9
Flaminia Fanelli, Federico Baronio, Rita Ortolano, Marco Mezzullo, Alessandra Cassio, Uberto Pagotto, Antonio Balsamo
In clinical practice, it is fundamental to compare the results of hormonal examinations obtained in the laboratory with reliable reference values. This is particularly difficult when faced with rare conditions, such as disorders of sex development, where not routinely assayed peptide hormones as well as intermediate steroid metabolites are often needed and local reliable reference values are not available. There are considerable differences among techniques and assays used in clinical and research laboratories...
February 14, 2018: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/29438900/sperm-quality-biomarkers-complement-reproductive-and-endocrine-parameters-in-investigating-environmental-contaminants-in-common-carp-cyprinus-carpio-from-the-lake-mead-national-recreation-area
#10
Jill A Jenkins, Michael R Rosen, Rassa O Draugelis-Dale, Kathy R Echols, Leticia Torres, Carla M Wieser, Constance A Kersten, Steven L Goodbred
Lake Mead National Recreational Area (LMNRA) serves as critical habitat for several federally listed species and supplies water for municipal, domestic, and agricultural use in the Southwestern U.S. Contaminant sources and concentrations vary among the sub-basins within LMNRA. To investigate whether exposure to environmental contaminants is associated with alterations in male common carp (Cyprinus carpio) gamete quality and endocrine- and reproductive parameters, data were collected among sub-basins over 7 years (1999-2006)...
February 10, 2018: Environmental Research
https://www.readbyqxmd.com/read/29436602/the-expression-and-activation-of-sex-steroid-receptors-in-the-preeclamptic-placenta
#11
Mee-Na Park, Kyung-Hee Park, Jae-Eon Lee, Ye Young Shin, Sung-Min An, Seong Soo Kang, Wan-Seob Cho, Beum-Soo An, Seung Chul Kim
Estrogen and progesterone are the main pregnancy hormones produced by the placenta. It is well understood that estrogen stimulates angiogenesis in the uterus during the reproductive cycle. Although the estrogen and progesterone signaling pathways are assumed to be associated with placental vascularization and preeclampsia, expression of estrogen receptors (ESRs) and progesterone receptor (PGR) in the placenta have not been well studied. The present study examined the expression patterns of steroid hormone receptors in placentas...
February 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29429521/sex-steroid-receptors-profiling-is-influenced-by-nandrolone-decanoate-in-the-ampulla-of-the-fallopian-tube-post-treatment-and-post-recovery-analyses
#12
G H B Andrade, V A Simão, B R Souza, L G A Chuffa, I C C Camargo
Anabolic androgenic steroids (AAS) are recommended for therapeutic clinic, but their use has increased in recent decades for aesthetic reasons. No study has evaluated the impact of AAS in the fallopian tube, after treatment and recovery periods. Herein, the aim of study was to investigate the effects of Nandrolone Decanoate (ND), administered in different doses (1.87; 3.75; 7.5 and 15 mg/kg) on the ampulla of the fallopian tube in rats, following post-treatment (PT; 15 consecutive days) and post-recovery (PR; 30 consecutive days) periods...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29428660/differential-expression-of-the-receptors-for-thyroid-hormone-thyroid-stimulating-hormone-vitamin-d-and-retinoic-acid-and-extracellular-signal-regulated-kinase-in-uterus-of-rats-under-influence-of-sex-steroids
#13
Abu Sadat Md Sayem, Nelli Giribabu, Kamarulzaman Karim, Lay Khiang Si, Sekaran Muniandy, Naguib Salleh
Sex-steroids play important role in modulating uterine functions. We hypothesized that these hormones affect expression of proteins in the uterus related to thyroid hormone action. Therefore, changes in expression levels of receptors for thyroid hormone (TRα-1 and TRβ-1), thyroid stimulating hormone (TSHR), vitamin D (VDR) and retinoid acid (RAR) as well as extracellular signal-regulated kinase (ERK1/2) in uterus were investigated under sex-steroid influence. METHODS: Two rat models were used: (i) ovariectomised, sex-steroid replaced and (ii) intact, at different phases of oestrous cycle...
February 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29427631/urofecal-steroid-profiles-of-captive-blue-fronted-parrots-amazona-aestiva-with-different-reproductive-outcomes
#14
Ricardo J G Pereira, Mauricio D Christofoletti, Marcel H Blank, José Mauricio B Duarte
Despite Psitaciformes (parrots) being the third largest nonpasserine order (398 species), it currently ranks second in number of threatened species (28%) according to the Internatinal Union for Conservation of Nature (IUCN) criteria. Since most of the literature concerning reproductive endocrinology in avian species derives from domestic and song birds, it is puzzling that advances in reproductive science for the Psitaciformes order lags far behind, in spite of the growing threats against them. In order to expand our knowledge of Neotropical parrots (Psittacidae), we examined annual changes in urofecal sex steroid metabolites of Blue-fronted amazon pairs (Amazona aestiva) exhibiting successful (nestlings) and unsuccessful breeding (infertile or no eggs)...
February 7, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29427137/childhood-peripheral-facial-palsy
#15
Zeynep Selen Karalok, Birce Dilge Taskin, Zeynep Ozturk, Esra Gurkas, Tuba Bulut Koc, Alev Guven
OBJECTIVE: The objectives of this study were to evaluate the demographic and clinical characteristics, causes, treatment patterns, outcome, and recurrence of childhood peripheral facial palsy. METHODS: We performed a retrospective study of 144 peripheral facial palsy patients, under 18 years old in a tertiary care pediatric hospital. Medical charts were reviewed to analyze the age, gender, side of facial nerve paralysis, family history, cause, grading by the House-Brackmann Facial Nerve Grading Scale (HBS), results of diagnostic tests, therapies, outcomes, and recurrence...
February 9, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29425789/refining-androstenedione-and-bisnorcholenaldehyde-from-mother-liquor-of-phytosterol-fermentation-using-macroporous-resin-column-chromatography-followed-by-crystallization
#16
Shi-Dong Xu, Fang-Hong Ning, Bang-He Jiang, Huan-Xin Xu, Zuo-Zhen Liu
Androstenedione is an androgen and intermediate in the biosynthesis of most adrenocortical, anabolic, sex and synthetic steroids, such as canrenone, eplerenone, norethindrone and spironolactone. Bisnorcholenaldehyde is an important intermediate in the synthesis of progesterone. This study established an androstenedione and bisnorcholenaldehyde separation method that used a macroporous adsorption resin and an ethanol-water mixture as eluent. The adsorption properties of 12 non-polar or weakly polar macroporous adsorption resins were compared, and three resins exhibited a high adsorption capacity and high desorption rate for both androstenedione and bisnorcholenaldehyde...
September 21, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29425227/interaction-between-polymorphisms-in-aspirin-metabolic-pathways-regular-aspirin-use-and-colorectal-cancer-risk-a-case-control-study-in-unselected-white-european-populations
#17
Harsh Sheth, Emma Northwood, Cornelia M Ulrich, Dominique Scherer, Faye Elliott, Jennifer H Barrett, David Forman, C Roland Wolf, Gillian Smith, Michael S Jackson, Mauro Santibanez-Koref, Robert Haile, Graham Casey, Mark Jenkins, Aung Ko Win, John L Hopper, Loic Le Marchand, Noralane M Lindor, Stephen N Thibodeau, John D Potter, John Burn, D Timothy Bishop
Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin's chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two large population-based case-control datasets, the UK-Leeds Colorectal Cancer Study Group and the NIH-Colon Cancer Family Registry, having a combined total of 3325 cases and 2262 controls. The aim was to assess 42 candidate SNPs in 15 genes whose association with colorectal cancer risk was putatively modified by aspirin use, in the literature...
2018: PloS One
https://www.readbyqxmd.com/read/29422865/dietary-safety-assessment-of-flk1-transgenic-fish
#18
Yalan Wei, Ling Huang, Jinghui Cao, Chenghui Wang, Jizhou Yan
Genetic engineering, also called genetic modification, is facing with growing demands of aquaculture and aquatic products. Although various genetically modified (GM) aquatics have been generated, it is important to evaluate biosafety of GM organisms on the human health before entering into our food chain. For this purpose, we establish a zebrafish wild adult feeding Flk1-transgenic larvae model to examine the predatory fish's histology in multiple tissues, and the global gene expression profile in the liver...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29421537/neuronal-activity-in-the-sagittalis-nucleus-of-the-hypothalamus-after-ovarian-steroid-hormone-manipulation-and-sexual-behavior-in-female-rat
#19
Ivaylo Evgueniev Balabanov, Ken Ichi Matsuda, Hiroko Mori, Shunji Yamada, Keito Kitagawa, Yukina Yamamoto, Shinji Tsukahara, Masaki Tanaka
During extended observation of estrogen receptor (ER) α-immunoreactive neurons in the hypothalamus, we previously identified a novel nucleus, the Sagittalis Nucleus of the Hypothalamus (SGN), in the interstitial area between the arcuate nucleus and the ventromedial hypothalamic nucleus. The SGN exhibits sexual dimorphism in its volume and cell count, and estrous cycle related variations in ERα-immunoreactivity. These characteristics of the SGN implicate the nucleus in sex-biased brain functions and behaviors...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29421409/prenatal-exposure-to-glycol-ethers-and-sex-steroid-hormones-at-birth
#20
Charline Warembourg, Anne-Claire Binter, Frank Giton, Jean Fiet, Laurence Labat, Christine Monfort, Cécile Chevrier, Luc Multigner, Sylvaine Cordier, Ronan Garlantézec
BACKGROUND: Glycol ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants. OBJECTIVES: To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure. METHODS: The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006)...
January 31, 2018: Environment International
keyword
keyword
22696
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"