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https://www.readbyqxmd.com/read/28109018/gonad-histology-and-serum-11-kt-profile-during-the-annual-reproductive-cycle-in-sterlet-sturgeon-adult-males-acipenser-ruthenus
#1
A Golpour, C Broquard, S Milla, H Dadras, A R Baloch, T Saito, M Pšenička
The aim of this study was to assess monthly testicular development in the cultured breeding stock of sterlet, Acipenser ruthenus, using histological and serum sex steroid changes. Testicular development in the adult male was examined monthly and showed four distinct phases including resting, pre-spawning, spawning and post-spawning. Also, seasonal changes of the testes were described according to its variations in gonadosomatic index (GSI) during different phases of testicular development. Using histology, we identified continuous spermatogenesis and asynchronous gonad development pattern in the testes of male sterlet, which shows that regulation of annual gonadal cycle is influenced by season...
January 21, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28108667/effects-on-circulating-steroid-hormones-and-gene-expression-along-the-hypothalamus-pituitary-gonadal-axis-in-adult-japanese-quail-exposed-to-17%C3%AE-trenbolone-across-multiple-generations
#2
Natalie K Karouna-Renier, Yu Chen, Paula F P Henry, Catherine M Maddox, Daniel T Sprague
We investigated the effects of the androgenic growth promoter 17ß-trenbolone (17βTB) on adult Japanese quail (Coturnix japonica) exposed across three generations. The F0 generation was exposed after sexual maturity to 0, 1, 5, 10, 20, and 40 ppm through feed. The F1 generation was exposed in ovo by maternal transfer and through feed at the same doses as their parents. The F2 generation was exposed in ovo only. Levels of plasma sex steroids, gonadal Cytochrome P450 aromatase (CYP19A1) mRNA and select brain neuroendocrine peptide mRNAs were measured...
January 20, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28107717/diclofenac-can-exhibit-estrogenic-modes-of-action-in-male-xenopus-laevis-and-affects-the-hypothalamus-pituitary-gonad-axis-and-mating-vocalizations
#3
Norah Johanna Efosa, Wibke Kleiner, Werner Kloas, Frauke Hoffmann
Diclofenac (DCF) is a non-steroidal analgesic and antiphlogistic. Due to its tremendous use, DCF can be found in the environment, especially in sewage, but also surface waters, ground and drinking water. Previous studies indicated that DCF can modulate the reproductive physiology of fish by altering the expression of important key enzymes of the hypothalamus-pituitary-gonad-axis (HPG-axis) and might act as an estrogenic endocrine disrupting chemical (EDC). Other studies, however, demonstrated that DCF does not exhibit any estrogenicity...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28105366/ovarian-steroid-cell-tumor-not-otherwise-specified-a-case-report-and-literature-review
#4
Lili Qian, Zhen Shen, Xuefen Zhang, Dabao Wu, Ying Zhou
Steroid cell tumors (SCT), not otherwise specified (NOS) are particularly rare ovarian sex cord-stromal tumors, which comprise <0.1% of all ovarian tumors. These tumors are uncommon in patients' prior to puberty without any typical syndromes involving hirsutism, virilization and hypertension. We here in present the case of a 5-year-old female patient who presented with sudden abdominal pain, repeated vomiting and a pelvic mass. Our patient underwent urgent exploratory laparotomy and right salpingo-oophorectomy and the histopathological examination revealed an ovarian SCT-NOS...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28103902/relationship-between-crown-like-structures-and-sex-steroid-hormones-in-breast-adipose-tissue-and-serum-among-postmenopausal-breast-cancer-patients
#5
Maeve Mullooly, Hannah P Yang, Roni T Falk, Sarah J Nyante, Renata Cora, Ruth M Pfeiffer, Derek C Radisky, Daniel W Visscher, Lynn C Hartmann, Jodi M Carter, Amy C Degnim, Frank Z Stanczyk, Jonine D Figueroa, Montserrat Garcia-Closas, Jolanta Lissowska, Melissa A Troester, Stephen M Hewitt, Louise A Brinton, Mark E Sherman, Gretchen L Gierach
BACKGROUND: Postmenopausal obesity is associated with increased circulating levels of androgens and estrogens and elevated breast cancer risk. Crown-like structures (CLS; microscopic foci of dying adipocytes surrounded by macrophages) are proposed to represent sites of increased aromatization of androgens to estrogens. Accordingly, we examined relationships between CLS and sex-steroid hormones in breast adipose tissue and serum from postmenopausal breast cancer patients. METHODS: Formalin-fixed paraffin embedded benign breast tissues collected for research from postmenopausal women (n = 83) diagnosed with invasive breast cancer in the Polish Breast Cancer Study (PBCS) were evaluated...
January 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28102888/genetic-polymorphisms-in-estrogen-metabolic-pathway-associated-with-risks-of-alzheimer-s-disease-evidence-from-a-southern-chinese-population
#6
Lu Hua Chen, Yan Hui Fan, Patrick Yu Ping Kao, Deborah Tip Yin Ho, Joyce Cheuk Tung Ha, Leung Wing Chu, You-Qiang Song
OBJECTIVES: To investigate whether genetic variations on the estrogen metabolic pathway would be associated with risk of Alzheimer's disease (AD). DESIGN: Cross-sectional study. SETTING: Individuals were recruited at the Memory Clinic, Queen Mary Hospital, Hong Kong. PARTICIPANTS: Chinese individuals with (n = 426) and without (n = 350) AD. MEASUREMENTS: All subjects underwent a standardized cognitive assessment and genotyping of four candidate genes on the estrogen metabolic pathway (estrogen receptor α gene (ESR1), estrogen receptor β gene (ESR2), cytochrome P450 19A1 gene (CYP19A1), cytochrome P450 11A1 gene (CYP11A1))...
January 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28101307/review-and-recommendations-on-management-of-adult-female-thalassemia-patients-with-hypogonadism-based-on-literature-review-and-experience-of-icet-a-network-specialists
#7
REVIEW
Vincenzo De Sanctis, Ashraf T Soliman, Heba Elsedfy, Alice Albu, Soad Al Jaouni, Salvatore Anastasi, Maria Grazia Bisconte, Duran Canatan, Soteroula Christou, Shahina Daar, Salvatore Di Maio, Mohamed El Kholy, Doaa Khater, Mohamed Elshinawy, Yurdanur Kilinc, Roberto Mattei, Hala H Mosli, Alessandra Quota, Maria Grazia Roberti, Praveen Sobti, Saif Al Yaarubi, Saveria Canpisi, Christos Kattamis
BACKGROUND: Multi-transfused thalassemia major (TM) patients frequently develop severe endocrine complications, mainly due to iron overload, anemia, and chronic liver disease, which require prompt diagnosis, treatment and follow-up by specialists. The most common endocrine complication documented is hypogonadotropic hypogonadism which increases with age and associated comorbidities. It is thus important for physicians to have a clear understanding of the pathophysiology and management of this disorder...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28099288/assessing-the-agreement-between-radiologic-and-clinical-measurements-of-lumbar-and-cervical-epidural-depths-in-patients-undergoing-prone-interlaminar-epidural-steroid-injection
#8
James Harvey Jones, Naileshni Singh, Anna Nidecker, Chin-Shang Li, Scott Fishman
BACKGROUND: Fluoroscopy-guided epidural steroid injection (ESI) commonly is performed to treat radicular pain yet can lead to adverse events if the needle is not advanced with precision. Accurate preoperative assessment of the distance from the skin to the epidural space holds the potential for reducing the risks of adverse effects from ESI. It was hypothesized that the distance from the skin to the epidural space as measured on preoperative magnetic resonance imaging (MRI) would agree with the distance traveled by a Tuohy needle to reach the epidural space during midline, interlaminar ESI...
January 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28098598/science-of-intracrinology-in-postmenopausal-women
#9
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F Archer, Wulf H Utian
OBJECTIVE: To illustrate the marked differences between classical endocrinology that distributes hormones to all tissues of the body through the bloodstream and the science of intracrinology, whereby each cell of each peripheral tissue makes a small and appropriate amount of estrogens and androgens from the inactive precursor dehydroepiandrosterone (DHEA), DHEA being mainly of adrenal origin. Because only the inactivated sex steroids are released in the blood, influence in the other tissues is avoided...
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28096641/assessment-of-periodontal-health-status-in-postmenopausal-women-visiting-dental-hospital-from-in-and-around-meerut-city-cross-sectional-observational-study
#10
D Deepa, Gazal Jain
BACKGROUND: Puberty, menses, pregnancy, and menopause are the different phases of a woman's life which have a varied influence on oral health. During the menopause, women go through biological and endocrine changes, particularly in their sex steroid hormone production which affects their health. Because the oral mucosa contains estrogen receptors, variations in hormone levels can be seen directly in the oral cavity leading to a few oral conditions and diseases seen more frequently during postmenopausal years...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28096433/sex-differences-in-the-development-of-prolactinoma-in-mice-overexpressing-hcg%C3%AE-role-of-tgf%C3%AE-1
#11
Erika Yanil Faraoni, María Andrea Camilletti, Alejandra Inés Abeledo Machado, Laura Daniela Ratner, Fernanda De Fino, Ilpo T Huhtaniemi, Susana B Rulli, Graciela Diaz-Torga
Female transgenic mice that overexpress the human chorionic gonadotrophin β subunit (hCGβ+) develop prolactinomas, while hCGβ+ males do not. The high levels of circulating hCG induces massive luteinization in the ovary of hCGβ+ females, and progesterone becomes the primary steroid hormone produced, but estradiol remains at physiological level. The involvement of high levels of progesterone in lactotroph proliferation is not clearly understood; hence the pathogenesis of prolactinomas in hCGβ+ females remains unclear...
January 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28095810/neonatal-screening-for-congenital-adrenal-hyperplasia-in-southern-brazil-a-population-based-study-with-108-409-infants
#12
Cristiane Kopacek, Simone Martins de Castro, Mayara Jorgens Prado, Claudia Maria Dornelles da Silva, Luciana Amorim Beltrão, Poli Mara Spritzer
BACKGROUND: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder associated with inborn errors of steroid metabolism. 21-hydroxylase enzyme deficiency occurs in 90 to 95% of all cases of CAH, with accumulation of 17 hydroxyprogesterone (17-OHP). Early diagnosis of CAH based on newborn screening is possible before the development of symptoms and allows proper treatment, correct sex assignment, and reduced mortality rates. This study describes the results obtained in the first year of a public CAH screening program in the state of Rio Grande do Sul, Brazil...
January 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28094108/analysis-of-primary-treatment-and-prognosis-of-spontaneous-urticaria
#13
Toshihiko Tanaka, Makiko Hiragun, Michihiro Hide, Takaaki Hiragun
BACKGROUND: The prognosis of spontaneous urticaria in association with early treatment remains unclear. In this study, we retrospectively studied the prognosis of acute spontaneous urticaria in relation to age and treatments in a local clinic of dermatology. METHODS: Out of 5000 patients who visited an office dermatology clinic, clinical records of patients with spontaneous urticaria were extracted. Their prognosis and the relation to age and treatments were analyzed by the Kaplan-Meier method and generalized Wilcoxon test...
January 13, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28093231/the-effects-of-6-gingerol-on-reproductive-improvement-liver-functioning-and-cyclooxygenase-2-gene-expression-in-estradiol-valerate-induced-polycystic-ovary-syndrome-in-wistar-rats
#14
Parisa Sadat Pournaderi, Parichehreh Yaghmaei, Hamidreza Khodaei, Zahra Noormohammadi, Seyed Hossein Hejazi
6- gingerol is the major pungent ingredient of ginger with anti-inflammatory and antioxidant properties. In this study, we evaluate the effects of 6- gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats. Thirty six female Wistar rats were divided into 4 groups: control, received normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6- gingerol (200 μg/kg and 400 μg/kg) for 14 days...
January 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28092110/simultaneous-detection-of-three-sex-steroid-hormone-classes-using-a-novel-yeast-based-biosensor
#15
Alexandre Chamas, Ha Thi Minh Pham, Martin Jähne, Karina Wettwer, Steffen Uhlig, Kirsten Simon, Almuth Einspanier, Kim Baronian, Gotthard Kunze
A biosensor detecting estrogens, progestogens and androgens in complex samples and in a single step is described. Three Arxula adeninivorans yeast strains were created, each strain producing a different recombinant human hormone receptor and a different fluorescent reporter protein. These strains were then mixed to create G1212/YRC102-hHR-fluo, the biological component of the biosensor. During incubation with G1212/YRC102-hHR-fluo, hormones present in a sample bind to their target receptor, which leads to the production of a specific fluorescent protein...
January 16, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28090348/changes-in-hba1c-and-circulating-and-adipose-tissue-androgen-levels-in-overweight-obese-women-with-polycystic-ovary-syndrome-in-response-to-electroacupuncture
#16
E Stener-Victorin, M Maliqueo, M Soligo, V Protto, L Manni, E Jerlhag, M Kokosar, A Sazonova, C J Behre, M Lind, C Ohlsson, K Højlund, A Benrick
AIM: Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS. MATERIAL AND METHODS: Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28089186/predictors-of-same-day-discharge-in-primary-total-joint-arthroplasty-patients-and-risk-factors-for-post-discharge-complications
#17
Alex Sher, Aakash Keswani, Dong-Han Yao, Michael Anderson, Karl Koenig, Calin S Moucha
BACKGROUND: Same-day (<24 h) discharge total joint arthroplasty (TJA) may be a safe and effective option for certain patients with end-stage osteoarthritis. Given the growing pressure to improve quality and lower TJA episode costs, surgeons must identify which TJA patients can be appropriately discharged home quickly and safely. This study identifies characteristics associated with same-day discharge post-TJA as well as assesses risk factors for complications in this select patient population...
December 22, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28078471/effects-of-estrogen-on-esophageal-function-through-regulation-of-ca-2-related-proteins
#18
Kipung Kim, Dongoh Lee, Changhwan Ahn, Hee Young Kang, Beum-Soo An, Yeon Hee Seong, Eui-Bae Jeung
BACKGROUND: The calcium ion is important for physiological functions in all tissues and organs and essential to many vital functions, including hormone secretion and muscle contraction. The intracellular concentration of calcium is regulated by calcium related proteins such as CaBP-9k, PMCA1, and NCX1. In this study, we investigated the relationship between calcium regulation and esophageal functions such as mucin secretion and smooth muscle contraction. METHODS: To evaluate the influence of sex steroid hormones, immature rats were treated for 3 days with estradiol (E2), progesterone (P4), and their antagonists (ICI 182,780, and RU486)...
January 11, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28077765/acute-embryonic-anoxia-exposure-favours-the-development-of-a-dominant-and-aggressive-phenotype-in-adult-zebrafish
#19
Catherine M Ivy, Cayleih E Robertson, Nicholas J Bernier
Eutrophication and climate change are increasing the incidence of severe hypoxia in fish nursery habitats, yet the programming effects of hypoxia on stress responsiveness in later life are poorly understood. In this study, to investigate whether early hypoxia alters the developmental trajectory of the stress response, zebrafish embryos were exposed to 4 h of anoxia at 36 h post-fertilization and reared to adults when the responses to secondary stressors were assessed. While embryonic anoxia did not affect basal cortisol levels or the cortisol response to hypoxia in later life, it had a marked effect on the responses to a social stressor...
January 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28077332/molecular-identification-of-star-and-3%C3%AE-hsd1-and-characterization-in-response-to-gnih-stimulation-in-protogynous-hermaphroditic-grouper-epinephelus-coioides
#20
Qingqing Wang, Xin Qi, Haipei Tang, Yin Guo, Shuisheng Li, Gaofei Li, Xiaoli Yang, Haifa Zhang, Xiaochun Liu, Haoran Lin
Gonadal steroids are critical factors in reproduction and sex reverse process. StAR (steroidogenic acute regulatory protein), transferring the cholesterol from the outer mitochondrial membrane to the inner membrane, is the rate-limiting factor of steroidogenesis. 3βHSD (3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase), converting Δ5-steroids into Δ4-steroids, is an important oxidoreductase in steroidogenesis. In the present study, StAR and 3βHSD1 were cloned and characterized from protogynous orange-spotted grouper...
January 8, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
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