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https://www.readbyqxmd.com/read/29653158/mice-deficient-in-akap13-brx-develop-compulsive-like-behavior-and-increased-body-weight
#1
K Maravet Baig, Szu-Chi Su, Sunni L Mumford, Emma Giuliani, Sinnie Sin Man Ng, Charles Armstrong, Margaret F Keil, Kamaria Cayton Vaught, Nils Olsen, Elyse Pettiford, Irina Burd, James H Segars
OBJECTIVE: Hormonal contributions to the sex-dependent development of both obsessive-compulsive disorder (OCD) and obesity have been described, but the underlying mechanisms are incompletely understood. A-kinase anchoring protein 13 (AKAP13) significantly augments ligand-dependent activation of estrogen receptors alpha and beta. The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression. The AKAP13 localization pattern observed in these key brain regions together with its effects on sex steroid action suggest a potential role for AKAP13 in compulsive-like behaviors...
April 10, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29651261/defining-the-construct-of-synthetic-androgen-intoxication-an-application-of-general-brain-arousal
#2
Tom Hildebrandt, Ashley Heywood, Daniel Wesley, Kurt Schulz
Synthetic androgens (i. e., anabolic-androgenic steroids) are the primary component to the majority of problematic appearance and performance enhancing drug (APED) use. Despite evidence that these substances are associated with increased risk for aggression, violence, body image disturbances, and polypharmacy and can develop a pattern of chronic use consistent with drug dependence, there are no formal definitions of androgen intoxication. Consequently, the purpose of this paper is to establish a testable theory of androgen intoxication...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29649433/repurposing-sex-steroids-and-related-drugs-as-potential-treatment-for-parkinson-s-disease
#3
REVIEW
Mélanie Bourque, Marc Morissette, Thérèse Di Paolo
Parkinson's disease (PD) is a neurodegenerative disorder for which a greater prevalence and incidence is described in men. This suggests a protective effect of sex hormones in the brain. Therefore, steroids and drugs to treat endocrine conditions could have additional application for PD. Here, we review the protective effect of sex hormones, particularly estrogens, progesterone, androgens and dehydroepiandrosterone, in animal models of PD and also in human studies. Data also support that drugs affecting estrogen neurotransmission such as selective estrogen receptor modulators or affecting steroid metabolism with 5α-reductase inhibitors could be repositioned for treatment of PD...
April 9, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29645316/neuropeptide-and-steroid-hormone-mediators-of-neuroendocrine-regulation
#4
REVIEW
Ashley L Heck, Carlos C Crestani, Alonso Fernández-Guasti, Darwin O Larco, Artur Mayerhofer, Charles E Roselli
In order to maintain the health and wellbeing of all mammals, numerous aspects of physiology are controlled by neuroendocrine mechanisms. These mechanisms ultimately enable communication between neurons and glands throughout the body and are centrally mediated by neuropeptides and/or steroid hormones. A recent session at the International Workshop in Neuroendocrinology highlighted essential roles for some of these neuropeptide and steroid hormone mediators in the neuroendocrine regulation of stress-, reproduction-, and behavior- related processes...
April 12, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29645315/cell-and-molecular-mechanisms-behind-diet-induced-hypothalamic-inflammation-and-obesity
#5
REVIEW
Yenniffer Ávalos, Bredford Kerr, Manuel Maliqueo, Mauricio Dorfman
Diet-induced obesity (DIO) is associated with chronic, low-grade inflammation in the hypothalamus, a key regulator of energy homeostasis. Current studies have revealed the involvement of different cell types as well as cell and molecular mechanisms that contribute to diet-induced hypothalamic inflammation (DIHI) and DIO. Since the discovery that high-fat diet and saturated fatty acids (SFAs) increase the expression of hypothalamic cytokines prior to weight gain, research has focused on understanding the cellular and molecular mechanisms underlying these changes, and what the role of inflammation in the obesity pathogenesis...
April 12, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29643853/gender-bias-in-human-systemic-lupus-erythematosus-a-problem-of-steroid-receptor-action
#6
Virginia Rider, Nabih I Abdou, Bruce F Kimler, Nanyan Lu, Susan Brown, Brooke L Fridley
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease resulting from abnormal interactions between T and B cells. The acquisition of SLE is linked to genetic susceptibility, and diverse environmental agents can trigger disease onset in genetically susceptible individuals. However, the strongest risk factor for developing SLE is being female (9:1 female to male ratio). The female sex steroid, estradiol, working through its receptors, contributes to the gender bias in SLE although the mechanisms remain enigmatic...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29643836/tau-phosphorylation-in-female-neurodegeneration-role-of-estrogens-progesterone-and-prolactin
#7
REVIEW
Daniel Muñoz-Mayorga, Christian Guerra-Araiza, Luz Torner, Teresa Morales
Sex differences are important to consider when studying different psychiatric, neurodevelopmental, and neurodegenerative disorders, including Alzheimer's disease (AD). These disorders can be affected by dimorphic changes in the central nervous system and be influenced by sex-specific hormones and neuroactive steroids. In fact, AD is more prevalent in women than in men. One of the main characteristics of AD is the formation of neurofibrillary tangles, composed of the phosphoprotein Tau, and neuronal loss in specific brain regions...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29628553/a-comparative-study-of-botulinum-toxin-a-with-triamcinolone-compared-to-triamcinolone-alone-in-the-treatment-of-osteoarthritis-of-knee
#8
Divya Shukla, Smitha K Sreedhar, Virendra Rastogi
Introduction: This study compares the efficacy in terms of pain relief and complications of intra-articular Botulinum toxin-A (BoNT-A) with intra-articular Triamcinolone versus Triamcinolone alone in the treatment of osteoarthritic knee pain of severe grade. If effective, BoNT-A may help in reducing the long term adverse effects due to prolonged analgesic consumption and reduce/delay requirement of knee replacement surgeries. Materials and Methods: In this prospective study, 30 patients of either sex, aged between 40 to 60 years with physical status ASA classes I or II suffering from knee joint osteoarthritis with knee pain and functional impairment were divided into 2 groups: The OA patients which received Botulinum toxin-A with Triamcinolone (Group A) & OA patients which received only Triamcinolone (Group B)...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29626053/insulin-like-growth-factors-actions-on-the-skeleton
#9
Shoshana Yakar, Haim Werner, Cliff Rosen
The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins), insulin-like growth factor (IGF)-I and -II, has elicited an enormous interest primarily amongst endocrinologists who study growth and metabolism. The advancement of molecular endocrinology over the past four decades enables investigators to re-examine and refine the established somatomedin hypothesis. Specifically, gene deletions, transgene overexpression, or more recently, cell-specific gene-ablations, have enabled investigators to study the effects of the Igf-I and Igf-II genes in temporal and spatial manners...
April 6, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29622354/perioperative-risk-factors-for-hospital-readmission-after-elective-endovascular-aortic-aneurysm-repair
#10
Samuel L Chen, Isabella J Kuo, Nii-Kabu Kabutey, Fady Gabra, Roy M Fujitani
BACKGROUND: Elective endovascular aneurysm repair (EVAR) is generally well tolerated. However, the incidence of hospital readmission after EVAR and the risk factors and reasons for it are not well studied. This study sought to determine the incidence, to characterize the indications, and to identify perioperative patient-centered risk factors for hospital readmission within 30 days after elective EVAR. METHODS: All patients who underwent EVAR electively in 2012 to 2013 were identified from the American College of Surgeons National Surgical Quality Improvement Program Targeted Vascular database (n = 3886)...
April 2, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29616724/sex-determination-and-gonadal-sex-differentiation-in-the-chicken-model
#11
Claire E Hirst, Andrew T Major, Craig A Smith
Our understanding of avian sex determination and gonadal development is derived primarily from the studies in the chicken. Analysis of gynandromorphic chickens and experimental chimeras indicate that sexual phenotype is at least partly cell autonomous in the chicken, with sexually dimorphic gene expression occurring in different tissue and different stages. Gonadal sex differentiation is just one of the many manifestations of sexual phenotype. As in other birds, the chicken has a ZZ male: ZW female sex chromosome system, in which the male is the homogametic sex...
2018: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29608946/phytoestrogens-and-mycoestrogens-interacting-with-breast-cancer-proteins
#12
Diana Montes-Grajales, Esperanza Martínez-Romero, Jesus Olivero-Verbel
Breast cancer is a highly heterogeneous disease influenced by the hormonal microenvironment and the most common malignancy in women worldwide. Some phytoestrogens and mycoestrogens have been epidemiologically linked as risk factors or protectors, however their mechanisms of action are complex and not fully understood. The aim of this study was to predict the potential of 36 natural xenoestrogens to interact with 189 breast cancer proteins using AutoDock Vina. In order to validate our protocol, an in silico docking pose and binding site determination was compared with the crystallographic structure and the power of prediction to distinguish between ligand and decoys was evaluated though a receiver operating characteristic curve (ROC) of the resultant docking affinities and in vitro data...
March 30, 2018: Steroids
https://www.readbyqxmd.com/read/29608891/change-of-the-5%C3%AE-5%C3%AE-ratio-of-urinary-steroid-metabolites-in-benign-prostatic-hyperplasia-patients-treated-with-dutasteride
#13
Takahiro Maeda, Eiji Kikuchi, Masanori Hasegawa, Keiko Homma, Yota Yasumizu, Seiya Hattori, Takeo Kosaka, Kazunobu Shinoda, Akira Miyajima, Mototsugu Oya
BACKGROUND: The effects of the administration of dutasteride (DUT) on steroid metabolite pathways in BPH patients have not been examined. METHODS: Urine and blood samples as well as clinical parameters were prospectively collected after the administration of DUT to 60 BPH patients, and after its withdrawal in another set of 25 BPH patients. Urine samples were assessed using gas chromatography/mass spectrometry for the urinary steroid profile (USP), which simultaneously measures 63 steroid metabolites...
March 30, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29607489/development-of-multifaceted-risk-taking-and-the-relations-to-sex-steroid-hormones-a-longitudinal-study
#14
Jiska S Peper, Barbara R Braams, Neeltje E Blankenstein, Marieke G N Bos, Eveline A Crone
Risk taking is a multidimensional construct. It is currently unclear which aspects of risk-taking change most during adolescence and if/how sex hormones contribute to risk-taking tendencies. This study applied a longitudinal design with three time-points, separated by 2 years, in participants aged 8-29 years (670 observations). The Balloon Analogue Risk Task, a delay discounting task, and various self-report questionnaires were administered, to measure aspects of risk taking. Longitudinal analyses demonstrated mostly nonlinear age-related patterns in risk-taking behavior and approach-related personality characteristics (peaking in late adolescence)...
April 1, 2018: Child Development
https://www.readbyqxmd.com/read/29606788/chemical-composition-of-axillary-odorants-reflects-social-and-individual-attributes-in-rhesus-macaques
#15
Brigitte M Weiß, Marlen Kücklich, Ruth Thomsen, Stefanie Henkel, Susann Jänig, Lars Kulik, Claudia Birkemeyer, Anja Widdig
Abstract: Scents play an important role in the life of most terrestrial mammals and may transmit valuable information about conspecifics. Olfaction was long considered of low importance in Old World monkeys due to their relative reduction of olfactory structures and low incidence of scent-marking behavior but has been increasingly recognized for mediating social relationships in recent years. Yet, studies investigating the composition of their chemical cues remain scarce. In the present study, we analyzed the potential information content of chemicals present on the skin of rhesus macaques ( Macaca mulatta )...
2018: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/29605635/rapid-changes-in-auditory-processing-in-songbirds-following-acute-aromatase-inhibition-as-assessed-by-fmri
#16
REVIEW
Annemie Van der Linden, Jacques Balthazart
This review introduces functional MRI (fMRI) as an outstanding tool to assess rapid effects of sex steroids on auditory processing in seasonal songbirds. We emphasize specific advantages of this method as compared to other more conventional and invasive methods used for this purpose and summarize an exemplary auditory fMRI study performed on male starlings exposed to different types of starling song before and immediately after the inhibition of aromatase activity by an i.p. injection of Vorozole™. We describe how most challenges that relate to the necessity to anesthetize subjects and minimize image- and sound-artifacts can be overcome in order to obtain a voxel-based 3D-representation of changes in auditory brain activity to various sound stimuli before and immediately after a pharmacologically-induced depletion of endogenous estrogens...
March 29, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29604381/sex-differences-and-estrous-cycle-changes-in-synaptic-plasticity-related-microrna-in-the-rat-medial-amygdala
#17
Mauro Mozael Hirsch, Janaína Brusco, Tamara Vaccaro, Rogerio Margis, Jorge E Moreira, Carmem Gottfried, Alberto A Rasia-Filho
The posterodorsal medial amygdala (MePD) is a sex steroid-sensitive and sexually dimorphic subcortical area that dynamically modulates social behaviors in rats. As different microRNA (miRNA) can act as post-transcriptional regulators of synaptic processing, we addressed changes that occur in miRNA expression in the MePD of males and females along the estrous cycle. The expression of miR25-3p, miR132-3p, miR138-5p, miR181a-5p, miR195-5p, and miR199a-5p, involved in neuronal cytoskeleton remodeling and synaptic plasticity, were evaluated by RT-qPCR...
March 28, 2018: Neuroscience
https://www.readbyqxmd.com/read/29602614/estradiol-protects-white-matter-of-male-c57bl6j-mice-against-experimental-chronic-cerebral-hypoperfusion
#18
Reymundo Dominguez, Madison Zitting, Qinghai Liu, Arati Patel, Robin Babadjouni, Drew M Hodis, Robert H Chow, William J Mack
BACKGROUND AND PURPOSE: Estradiol is a sex steroid hormone known to protect the brain against damage related to transient and global cerebral ischemia. In the present study, we leverage an experimental murine model of bilateral carotid artery stenosis (BCAS) to examine the putative effects of estradiol therapy on chronic cerebral hypoperfusion. We hypothesize that long-term estradiol therapy protects against white matter injury and declarative memory deficits associated with chronic cerebral hypoperfusion...
March 27, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29600719/comparison-of-plantar-fasciitis-injected-with-platelet-rich-plasma-vs-corticosteroids
#19
Sumit Kumar Jain, Kumar Suprashant, Sanjeev Kumar, Arun Yadav, Stephen R Kearns
BACKGROUND: Plantar fasciitis is one of the most common causes of heel pain. This prospective study compared the efficacy of local injection of corticosteroids vs platelet-rich plasma (PRP) in the treatment of plantar fasciitis. METHODS: Patients were randomly allocated into 2 groups of 40 each (group A and group B). Patients were treated with local corticosteroid injection in group A and autologous PRP injection in group B. Clinical assessment was done prior to the injection and at 1 month, 3 months, and 6 months following the injection, which included visual analog pain scale, subjective rating using the modified Roles and Maudsley score, functional outcome score by the Foot and Ankle Outcome Instrument (FAI) core scale, and the American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot scale...
March 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29595516/a-rare-cause-of-congenital-adrenal-hyperplasia-clinical-and-genetic-findings-and-follow-up-characteristics-of-six-patients-with-17-hydroxylase-deficiency-and-two-novel-mutations
#20
Aslı Derya Kardelen, Güven Toksoy, Firdevs Baş, Zehra Yavaş Abalı, Genco Gençay, Şükran Poyrazoğlu, Rüveyde Bundak, Umut Altunoğlu, Şahin Avcı, Adam Najaflı, Oya Uyguner, Birsen Karaman, Seher Başaran, Feyza Darendeliler
BACKGROUND: 17-α-hydroxylase/17,20 lyase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia (CAH), characterized by hypertension and varying degrees of ambiguous genitalia and delayed pu-berty. The disease is associated with bi-allelic mutations in the CYP17A1 gene located on chromosome 10q24.3. We aimed to present clinical and genetic findings and follow-up and treatment of 17-OHD patients. PATIENTS AND METHODS: We evaluated six patients with 17OHD from five families at presentation and at follow up...
March 29, 2018: Journal of Clinical Research in Pediatric Endocrinology
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