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Progestogens

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https://www.readbyqxmd.com/read/27907851/effects-of-antiandrogenic-progestins-chlormadinone-and-cyproterone-acetate-and-the-estrogen-17%C3%AE-ethinylestradiol-ee2-and-their-mixtures-transactivation-with-human-and-rainbowfish-hormone-receptors-and-transcriptional-effects-in-zebrafish-danio-rerio-eleuthero
#1
Patricia Franziska Siegenthaler, Peter Bain, Francesco Riva, Karl Fent
Synthetic progestins act as endocrine disrupters in fish but their risk to the environment is not sufficiently known. Here, we focused on an unexplored antiandrogenic progestin, chlormadinone acetate (CMA), and the antiandrogenic progestin cyproterone acetate (CPA). The aim was to evaluate whether their in vitro interaction with human and rainbowfish (Melanotaenia fluviatilis) sex hormone receptors is similar. Furthermore, we investigated their activity in zebrafish (Danio rerio) eleuthero-embryos. First, we studied agonistic and antagonistic activities of CMA, CPA, and 17α-ethinylestradiol (EE2), in recombinant yeast expressing either the human progesterone (PGR), androgen (AR), or estrogen receptor...
November 9, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27901412/oral-progestogens-versus-levonorgestrel-releasing-intrauterine-system-for-treatment-of-endometrial-intraepithelial-neoplasia
#2
Mary L Marnach, Kristina A Butler, Michael R Henry, Catherine E Hutz, Carrie L Langstraat, Christine M Lohse, Petra M Casey
BACKGROUND: Limited therapeutic guidelines exist regarding medical therapy, ideal dosing, duration of therapy, or recommendations for timing of endometrial reassessment for women with endometrial intraepithelial neoplasia (EIN) who desire fertility preservation or who are not optimal surgical candidates. We aimed to determine the effectiveness of oral progestogens (OP) versus the levonorgestrel-releasing intrauterine system (LNG IUS) in the medical treatment of EIN. METHODS: We retrospectively identified women with EIN at our institution from 2007 through 2014 and compared the outcomes of those treated with OP versus LNG IUS...
November 30, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27900987/effect-of-half-dose-and-standard-dose-conjugated-equine-estrogens-combined-with-natural-progesterone-or-dydrogesterone-on-components-of-metabolic-syndrome-in-healthy-postmenopausal-women-a-randomized-controlled-trial
#3
Wei Xue, Yan Deng, Yan-Fang Wang, Ai-Jun Sun
BACKGROUND: Menopausal hormone therapy (MHT) has been proven to have beneficial effects on several components of metabolic syndrome. However, the effects vary according to different regimens, dosages, and duration of MHT. The aim of the study was to evaluate the effect of standard-dose 0.625 mg conjugated equine estrogen (CEE) and half-dose 0.3 mg CEE daily with different progestogens in a continuous sequential regimen on postmenopausal metabolic parameters in generally healthy postmenopausal women...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27898258/estradiol-therapy-and-breast-cancer-risk-in-perimenopausal-and-postmenopausal-women-a-systematic-review-and-meta-analysis
#4
Zhilan Yang, Ying Hu, Jing Zhang, Liangzhi Xu, Rujun Zeng, Deying Kang
OBJECTIVE: To investigate the association between estradiol therapy and incidence of breast cancer, taking into consideration of different types of combined progestogen, the duration of exposure and the type of regimen. METHOD: A systematic review and meta-analysis. RESULT: A total of 14 studies were included in our study. In estradiol-only therapy analysis, meta-analysis resulted a pooled OR =0.90, 95% CI (0.40, 2.02) from the RCTs and pooled OR = 1...
November 29, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27887710/supplementation-with-progestogens-in-the-first-trimester-of-pregnancy-to-prevent-miscarriage-in-women-with-unexplained-recurrent-miscarriage-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Gabriele Saccone, Corina Schoen, Jason M Franasiak, Richard T Scott, Vincenzo Berghella
OBJECTIVE: To investigate whether treatment with progestogens in the first trimester of pregnancy would decrease the incidence of miscarriage in women with a history of unexplained recurrent miscarriage. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Women with a history of unexplained recurrent miscarriage. INTERVENTION(S): Randomized, controlled trials were identified by searching electronic databases...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27885264/deciphering-the-divergent-roles-of-progestogens-in-breast-cancer
#6
Jason S Carroll, Theresa E Hickey, Gerard A Tarulli, Michael Williams, Wayne D Tilley
Most breast cancers are driven by oestrogen receptor-α. Anti-oestrogenic drugs are the standard treatment for these breast cancers; however, treatment resistance is common, necessitating new therapeutic strategies. Recent preclinical and historical clinical studies support the use of progestogens to activate the progesterone receptor (PR) in breast cancers. However, widespread controversy exists regarding the role of progestogens in this disease, hindering the clinical implementation of PR-targeted therapies...
November 25, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27884916/usual-medical-treatments-or-levonorgestrel-ius-for-women-with-heavy-menstrual-bleeding-long-term-randomised-pragmatic-trial-in-primary-care
#7
Joe Kai, Lee Middleton, Jane Daniels, Helen Pattison, Konstantinos Tryposkiadis, Janesh Gupta
BACKGROUND: Heavy menstrual bleeding (HMB) is a common, chronic problem affecting women and health services. However, long-term evidence on treatment in primary care is lacking. AIM: To assess the effectiveness of commencing the levonorgestrel-releasing intrauterine system (LNG-IUS) or usual medical treatments for women presenting with HMB in general practice. DESIGN AND SETTING: A pragmatic, multicentre, parallel, open-label, long term, randomised controlled trial in 63 primary care practices across the English Midlands...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27843051/effect-of-hormone-replacement-therapy-with-the-anti-mineralocorticoid-progestin-drospirenone-compared-to-tibolone-on-endothelial-function-and-central-haemodynamics-in-post-menopausal-women
#8
Cristiana Vitale, Caterina Mammi, Marco Gambacciani, Novella Russo, Ilaria Spoletini, Massimo Fini, Maurizio Volterrani, Giuseppe M C Rosano
Drospirenone (DRSP) is an antialdosterone agent with progestogenic and antiandrogenic effects. This compound, has been recently used in combination with 17β-estradiol (E2) as hormonal therapy in postmenopausal women and has been shown to exert a significant antihypertensive effect in hypertensive post-menopausal women. Aim of the present study was to compare the effect of DRSP/E2 with those of Tibolone (T) on endothelial function, arterial stiffness, and lipid profile of early postmenopausal women naïve on post-menopausal hormonal therapy...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27835573/the-associations-between-mast-cell-infiltration-clinical-features-and-molecular-types-of-invasive-breast-cancer
#9
Jianfeng Sang, Dandan Yi, Xiaoqiao Tang, Yifen Zhang, Tao Huang
Associations between mast cell infiltration and the clinical features and known molecular profile of breast cancer remain unclear. The distribution difference of mast cell was evaluated, in 219 patients with no special type of invasive carcinoma, using sorts of age, max diameter of cancer, histological type, lymph node metastasis as well as the expressions of estrogen receptor (ER), progestogen receptor (PR), human epidermal growth factor receptor 2 (HER-2) and nuclear protein Ki67. The mast cell density (MCD) in patients younger than 50 years old was significantly higher than that in patients with age ≥ 50...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27818117/-induced-abortion-guidelines-for-clinical-practice%C3%A2-%C3%A2-text-of-the-guidelines-short-text
#10
C Vayssière, A Gaudineau, L Attali, K Bettahar, S Eyraud, P Faucher, P Fournet, D Hassoun, M Hatchuel, C Jamin, B Letombe, T Linet, M Msika Razon, A Ohanessian, H Segain, S Vigoureux, N Winer, S Wylomanski, A Agostini
OBJECTIVE: Develop recommendations for the practice of induced abortion. MATERIALS AND METHODS: The Pubmed database, the Cochrane Library and the recommendations from the French and foreign Gyn-Obs societies or colleges have been consulted. RESULTS: The number of induced abortions (IA) has been stable for several decades. There are a lot of factors explaining the choice of abortion when there is an unplanned pregnancy (UPP). Early initiation and choice of contraception in connection to the woman's life are associated with lower NSP...
November 3, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27793383/steroid-hormone-pretreatments-in-assisted-reproductive-technology
#11
REVIEW
Jean Nassar, Teddy Tadros, Elodie Adda-Herzog, Jean Marc Ayoubi, Renato Fanchin
Adequate availability and FSH sensitivity of ovarian antral follicles and coordination of their growth during controlled ovarian hyperstimulation (COH) rank among factors that may determine outcome, particularly in patients presenting ovarian function defects and so-called "poor responders." Growing evidence indicates that both factors are positively influenced by steroid hormone pretreatments. First, data from studies conducted in both animals and in women exposed to virilizing androgen doses indicate that androgen pretreatments may increase follicle responsiveness to FSH and/or the number of growing follicles in the ovary, thereby constituting an interesting perspective in the management of "poor responders...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27788052/efficacy-and-safety-of-an-injectable-combination-hormonal-contraceptive-for-men
#12
Hermann M Behre, Michael Zitzmann, Richard A Anderson, David J Handelsman, Silvia W Lestari, Robert I McLachlan, M Cristina Meriggiola, Man Mohan Misro, Gabriela Noe, Frederick C W Wu, Mario Philip R Festin, Ndema A Habib, Kirsten M Vogelsong, Marianne M Callahan, Kim A Linton, Doug S Colvard
CONTEXT: The development of a safe and effective reversible method of male contraception is still an unmet need. OBJECTIVE: Evaluation of suppression of spermatogenesis and contraceptive protection by coadministered im injections of progestogen and testosterone. DESIGN: Prospective multicentre study. SETTING: Ten study centers. PARTICIPANTS: Healthy men, aged 18-45 years, and their 18- to 38-year-old female partners, both without known fertility problems...
October 27, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27760481/is-progestogen-supplementation-necessary-to-prevent-abortion
#13
Ayşen Boza, Murat Api, Semra Kayatas, Mehmet Ceyhan, Baris Boza
A prospective study was conducted to evaluate the effect of progestogens on the pregnancy outcome of threatened abortion (TA). A total of 251 pregnant women less than 20 weeks of gestational age (GA) were included. Group 1 consisted of women with vaginal bleeding who had already been under treatment with progestogens and Group 2 was composed of women with vaginal bleeding who were only followed without progestogen therapy, whereas Group 3 was the control group without any vaginal bleeding or progestogen therapy...
October 20, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27755952/antioxidant-status-and-sex-hormones-in-women-with-complex-endometrial-hyperplasia
#14
S Pejić, A Todorović, V Stojiljković, I Pavlović, L Gavrilović, N Popović, S B Pajović
Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27749742/increased-expression-of-progesterone-receptor-membrane-component-1-is-associated-with-aggressive-phenotype-and-poor-prognosis-in-er-positive-and-negative-breast-cancer
#15
Xiangyan Ruan, Ying Zhang, Alfred O Mueck, Marina Willibald, Harald Seeger, Tanja Fehm, Sara Brucker, Hans Neubauer
OBJECTIVE: Expression of progesterone receptor membrane component 1 (PGRMC1) has been shown to be higher in breast cancer than normal tissue. We have previously shown that certain progestogens strongly stimulate proliferation of breast cancer cells overexpressing PGRMC1, and therefore hypothesize that PGRMC1 may play a critical role in breast cancer progression. Because little information is available if expression of PGRMC1 is also associated with worse prognosis for breast cancer patients, in this study we investigated the clinicopathologic significance of PGRMC1 expression in breast cancer tissue...
October 3, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27741193/progestogens-as-maintenance-treatment-in-arrested-preterm-labor-a-systematic-review-and-meta-analysis
#16
Montse Palacio, Stefania Ronzoni, Luis Sánchez-Ramos, Kellie E Murphy
OBJECTIVE: To evaluate the efficacy of maintenance tocolysis with progestogens compared with placebo or no treatment in women with singleton pregnancies and arrested preterm labor. DATA SOURCES: Studies without language restrictions were identified from MEDLINE, EMBASE, PubMed, Scopus, the Cochrane Pregnancy and Childbirth Group's Trials Register, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov from inception to June 2015. MeSH headings for progestogens were combined with terms regarding labor, tocolysis, or preterm birth...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27695365/continuation-rates-bleeding-profile-acceptability-and-satisfaction-of-women-using-an-oral-contraceptive-pill-containing-estradiol-valerate-and-dienogest-versus-a-progestogen-only-pill-after-switching-from-an-ethinylestradiol-containing-pill-in-a-real-life-setting
#17
Paula Briggs, Marco Serrani, Kai Vogtländer, Susanne Parke
BACKGROUND: Oral contraceptives are still associated with high discontinuation rates, despite their efficacy. There is a wide choice of oral contraceptives available, and the aim of this study was to assess continuation rates, bleeding profile acceptability, and the satisfaction of women in the first year of using a contraceptive pill containing estradiol valerate and dienogest (E2V/DNG) versus a progestogen-only pill (POP) in a real-life setting after discontinuing an ethinylestradiol-containing pill...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27688720/use-of-the-world-health-organization-s-medical-eligibility-criteria-for-contraceptive-use-guidance-in-sub-saharan-african-countries-a-cross-sectional-study
#18
Melissa J Chen, Mary E Gaffield, James Kiarie
Given recent updates to the postpartum contraception recommendations in the fifth edition of the Medical Eligibility Criteria for Contraceptive Use (MEC), published by the World Health Organization (WHO), the purpose of this qualitative study was to assess the extent to which national family planning policies in sub-Saharan African countries are in agreement with the WHO MEC, particularly with regard to postpartum contraceptive use. WHO headquarters sent questionnaires to country-level focal points to complete with their Ministry of Health counterparts...
September 28, 2016: Global Health, Science and Practice
https://www.readbyqxmd.com/read/27680324/association-of-hormonal-contraception-with-depression
#19
Charlotte Wessel Skovlund, Lina Steinrud Mørch, Lars Vedel Kessing, Øjvind Lidegaard
Importance: Millions of women worldwide use hormonal contraception. Despite the clinical evidence of an influence of hormonal contraception on some women's mood, associations between the use of hormonal contraception and mood disturbances remain inadequately addressed. Objective: To investigate whether the use of hormonal contraception is positively associated with subsequent use of antidepressants and a diagnosis of depression at a psychiatric hospital. Design, Setting, and Participants: This nationwide prospective cohort study combined data from the National Prescription Register and the Psychiatric Central Research Register in Denmark...
September 28, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27648594/prescribing-of-fda-approved-and-compounded-hormone-therapy-differs-by-specialty
#20
Ginger D Constantine, David F Archer, Shelli Graham, Brian A Bernick, Sebastian Mirkin
OBJECTIVE: To determine the prescribing patterns of general practitioners (GPs), obstetrician/gynecologists (OB/GYNs), and wellness physicians (WPs) of menopausal hormone therapy (HT) for both compounded (CHT) and Food and Drug Administration (FDA)-approved products, using a survey of US physicians. METHODS: Nine thousand one US physicians were invited to participate in a survey to report on their HT-prescribing patterns. Physicians were eligible if they prescribed HT for at least six patients per month...
October 2016: Menopause: the Journal of the North American Menopause Society
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