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https://www.readbyqxmd.com/read/29349660/progestogen-hypersensitivity
#1
REVIEW
Rung-Chi Li, Kathleen M Buchheit, Jonathan A Bernstein
PURPOSE OF REVIEW: Progestogen hypersensitivity (PH) is a rare disorder which usually occurs in women of childbearing age with symptoms ranging from urticaria with or without angioedema, multiple organ involvement consistent with allergic anaphylaxis, to a spectrum of other non-evanescent skin eruptions. In this review, we present a clinical vignette of PH and discuss the clinical presentation and proposed pathomechanisms, diagnosis, and treatment of PH. RECENT FINDINGS: The hypersensitivity symptoms are associated with exogenous progestin exposure (e...
January 19, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29347814/-customization-of-hormonal-contraception
#2
Vincenzo DE Leo, Antonio Cianci, Costantino DI Carlo, Valentina Cappelli, Franca Fruzzetti
In the last few years new oral contraceptives have been marketed showing a better safety profile for women. They are the result of important changes made to the old compounds. As far as the estrogenic component, with the aim of decreasing side effects, the dose of ethinyl estradiol has been reduced and synthetic estrogens have been replaced by natural estradiol, further improving the safety profile. Also the progestin component in the last years has been changed in terms of dose, endocrine and metabolic characteristics...
February 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29339693/simultaneous-total-occlusion-of-two-coronary-arteries-associated-with-use-of-drospirenone-ethinyl-estradiol-oral-contraceptive
#3
Hüsnü Atmaca, Diyar Köprülü, Tuncay Kiriş, Gönül Zeren, İrfan Şahin
Although the use of oral contraceptives is associated with an increased risk of venous thromboembolic disease, the risk of myocardial infarction (MI) is unclear. A new, third-generation contraceptive agent, drospirenone-ethinyl estradiol, which contains less estrogen and a new progestogen, drospirenone, in a different combination, has been considered more reliable in terms of risk of MI. However, there have been some cases of MI associated with the use of drospirenone-ethinyl estradiol, despite the protective effects of this oral contraceptive...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29316527/contrasting-effects-of-individual-versus-combined-estrogen-and-progestogen-regimens-as-working-memory-load-increases-in-middle-aged-ovariectomized-rats-one-plus-one-does-not-equal-two
#4
Alesia V Prakapenka, Ryoko Hiroi, Alicia M Quihuis, Catie Carson, Shruti Patel, Claire Berns-Leone, Carly Fox, Rachael W Sirianni, Heather A Bimonte-Nelson
Most estrogen-based hormone therapies are administered in combination with a progestogen, such as Levonorgestrel (Levo). Individually, the estrogen 17β-estradiol (E2) and Levo can improve cognition in preclinical models. However, although these hormones are often given together clinically, the impact of the E2 + Levo combination on cognitive function has yet to be methodically examined. Thus, we investigated E2 + Levo treatment on a cognitive battery in middle-aged, ovariectomized rats. When administered alone, E2 and Levo treatments each enhanced spatial working memory relative to vehicle treatment, whereas the E2 + Levo combination impaired high working memory load performance relative to E2 only and Levo only treatments...
December 7, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29284693/from-research-to-policy-the-who-experience-with-developing-guidelines-on-the-potential-risk-of-hiv-acquisition-and-progestogen-only-contraception-use
#5
Leo Han, Eva Patil, Nancy Kidula, Mary Lyn Gaffield, Petrus S Steyn
No abstract text is available yet for this article.
December 28, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29273454/effects-of-non-contingent-cocaine-on-3-alpha-androstanediol-ii-disruption-of-lordosis-of-proestrous-rats
#6
Amy S Kohtz, Alicia A Walf, Cheryl A Frye
Drug use influences sexual behavior, performance, and can be associated with increased sexual risk-taking. Our prior results using an animal model indicate that progestogens contribute to hormonally-mediated changes in sexual behavior of female rodents during acute cocaine exposure. Androgens, such as testosterone, and its metabolite 3ɑ-androstanediol (3α-diol), and estradiol, are known to influence male sexual behavior, but can also alter the expression of sexual behavior of female rodents. As such, we investigated the influence of endogenous androgen and estradiol fluctuations on cocaine-mediated changes in motor behavior and sexual receptivity of rats during diestrous or proestrous phases of the estrous cycle...
December 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29251308/in-vitro-assessment-of-sex-steroids-and-related-compounds-in-water-and-sediments-a-critical-review
#7
REVIEW
Chimi Wangmo, Sergio Jarque, Klára Hilscherová, Luděk Bláha, Michal Bittner
Detection of endocrine disrupting compounds in water and sediment samples has gained much importance since the evidence of their effects was reported in aquatic ecosystems in the 1990s. The aim of this review is to highlight the advances made in the field of in vitro analysis for the detection of hormonally active compounds with estrogenic, androgenic and progestogenic effects in water and sediment samples. In vitro assays have been developed from yeast, mammalian and in a few cases from fish cells. These assays are based either on the hormone-mediated proliferation of sensitive cell lines or on the hormone-mediated expression of reporter genes...
December 18, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29248852/determination-of-endocrine-disrupting-potencies-of-agricultural-soils-in-china-via-a-battery-of-steroid-receptor-bioassays
#8
Jianyun Zhang, Rui Liu, Lili Niu, Siyu Zhu, Quan Zhang, Meirong Zhao, Weiping Liu, Jing Liu
Pollution of agricultural soils by pesticides, such as organochlorine pesticides (OCPs), can be a significant issue since high detection rates of these compounds were reported in our previous studies. However, more uncertain kinds, quantities and density of pollutants remained in soil samples were unidentified. In this study, the total hormonal activities of complex mixtures of both known and unknown contaminants in agricultural soils in mainland China were measured by applying highly sensitive reporter gene assays for detecting agonists/antagonists for estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), glucocorticoid receptor (GR) and mineralocorticoid receptor (MR)...
December 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29202468/polycomb-subunit-bmi1-determines-uterine-progesterone-responsiveness-essential-for-normal-embryo-implantation
#9
Qiliang Xin, Shuangbo Kong, Junhao Yan, Jingtao Qiu, Bo He, Chan Zhou, Zhangli Ni, Haili Bao, Lin Huang, Jinhua Lu, Guoliang Xia, Xicheng Liu, Zi-Jiang Chen, Chao Wang, Haibin Wang
Natural and synthetic progestogens have been commonly used to prevent recurrent pregnancy loss in women with inadequate progesterone secretion or reduced progesterone sensitivity. However, the clinical efficacy of progesterone and its analogs for maintaining pregnancy is variable. Additionally, the underlying cause of impaired endometrial progesterone responsiveness during early pregnancy remains unknown. Here, we demonstrated that uterine-selective depletion of BMI1, a key component of the polycomb repressive complex-1 (PRC1), hampers uterine progesterone responsiveness and derails normal uterine receptivity, resulting in implantation failure in mice...
November 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29183399/evaluating-progestogens-for-prevention-of-preterm-birth-international-collaborative-epppic-individual-participant-data-ipd-meta-analysis-protocol
#10
Lesley A Stewart, Mark Simmonds, Lelia Duley, Kristina Charlotte Dietz, Melissa Harden, Alex Hodkinson, Alexis Llewellyn, Sahar Sharif, Ruth Walker, Kath Wright
BACKGROUND: Preterm birth is the most common cause of death and harm to newborn babies. Babies that are born early may have difficulties at birth and experience health problems during early childhood. Despite extensive study, there is still uncertainty about the effectiveness of progestogen (medications that are similar to the natural hormone progesterone) in preventing or delaying preterm birth, and in improving birth outcomes. The Evaluating Progestogen for Prevention of Preterm birth International Collaborative (EPPPIC) project aims to reduce uncertainty about the specific conditions in which progestogen may (or may not) be effective in preventing or delaying preterm birth and improving birth outcomes...
November 28, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29175412/dissolving-microneedles-loaded-with-etonogestrel-microcrystal-particles-for-intradermal-sustained-delivery
#11
Meilin He, Guozhong Yang, Suohui Zhang, Xiaoyu Zhao, Yunhua Gao
This study presents a design that lipophilic drug was encapsulated within dissolving microneedles (DMNs) for sustained-release delivery over one week. Etonogestrel (ENG), the progestogen used in hormonal contraceptives, was loaded in two-layered DMNs in form of microcrystal particles (MP). In vitro release study indicated that ENG in form of MP could sustain drug release compared to non-crystal form. Hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) was used to prepare the fast dissolving needle-tips and flexible back layer, respectively...
November 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29157280/the-effects-of-progesterones-on-blood-lipids-in-hormone-replacement-therapy
#12
REVIEW
Yifan Jiang, Weijie Tian
The safety of progestogens as a class has drawn much attention after the publication of data from the Women's Health Initiative (WHI) trial, particularly with respect to cardiovascular disease. Depending on the chemical structure, pharmacokinetics, receptor affinity and potency of action, progestogens have a divergent range of properties that may translate to very different clinical effects. The purpose of this review is to describe the role of varied progestogens in hormone replacement therapy (HRT), especially focusing on blood lipids, which are the most important parameters for assessing cardiovascular disease risk...
November 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29139352/-contraception-for-young-women-with-focus-on-long-acting-reversible-contraceptives
#13
EDITORIAL
Pernille Ravn, Kresten Rubeck Petersen
Long-acting, reversible contraceptives are about 20 times more effective in terms of contraceptive efficacy than oral hormonal contraceptives, patch or vaginal ring are. Long-acting, reversible contraceptives are not associated with serious adverse events but induce changes in menstrual bleeding pattern in about 75% of the users. The progestogen intrauterine device is effective in the treatment of menor-rhagia and dysmenorrhoea. Increased use of long-acting reversible contraceptives is expected to reduce unplanned pregnancies and legal abortions in all ages...
November 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29137347/antiandrogenic-and-antimineralocorticoid-health-benefits-of-coc-containing-newer-progestogens-dienogest-and-drospirenone
#14
REVIEW
Pedro-Antonio Regidor, Adolf E Schindler
Data have demonstrated that COCs, besides offering a satisfactory and safe contraception, offer a variety of non-contraceptive health benefits and therapeutic positive aspects. Many prescribes and users, however, do not realize these positive aspects especially the non-contraceptive health benefits. While the contraceptive use is the primary indication for COC use for most women, these users should be advised in regard of the non-contraceptive benefits when contraception is discussed and prescribed. Using COCs specifically for non-contraceptive indications is an off-label use in many clinical situations (only some exceptions as e...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132343/diet-and-endometrial-cancer-a-focus-on-the-role-of-fruit-and-vegetable-intake-mediterranean-diet-and-dietary-inflammatory-index-in-the-endometrial-cancer-risk
#15
Fulvio Ricceri, Maria Teresa Giraudo, Francesca Fasanelli, Dario Milanese, Veronica Sciannameo, Laura Fiorini, Carlotta Sacerdote
BACKGROUND: Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation. METHODS: In the framework of a case-control study, we recruited 297 women with newly diagnosed endometrial cancer and 307 controls from Northern Italy...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29120922/gender-dysphoria-in-youth-a-review-of-recent-literature
#16
Julia Cartaya, Ximena Lopez
PURPOSE OF REVIEW: Transgender individuals including pubertal young people require hormonal therapy, in conjunction with mental health support. These youths are a unique population, with specific and individual desires and needs as they move through the physical and mental transition to the gender with which they identify. RECENT FINDINGS: The number of transgender youth presenting for treatment is increasing rapidly. They continue to have a high prevalence of mental health disorders, though not when supported in their sex identities by family in younger age...
February 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29105931/medroxyprogesterone-acetate-treated-human-primary-endometrial-epithelial-cells-reveal-unique-gene-expression-signature-linked-to-innate-immunity-and-hiv-1-susceptibility
#17
Matthew W Woods, Muhammad Atif Zahoor, Sara Dizzell, Chris P Verschoor, Charu Kaushic
PROBLEM: Medroxyprogesterone acetate (MPA), a progestin-based hormonal contraceptive designed to mimic progesterone, has been linked to increased human immunodeficiency virus (HIV-1) susceptibility. Genital epithelial cells (GECs) form the mucosal lining of the female genital tract (FGT) and provide the first line of protection against HIV-1. The impact of endogenous sex hormones or MPA on the gene expression profile of GECs has not been comprehensively documented. METHOD OF STUDY: Using microarray analysis, we characterized the transcriptional profile of primary endometrial epithelial cells grown in physiological levels of E2, P4, and MPA...
November 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29102184/determination-of-progestogens-in-surface-and-waste-water-using-spe-extraction-and-lc-apci-appi-hrps
#18
Oksana Golovko, Pavel Šauer, Ganna Fedorova, Hana Kocour Kroupová, Roman Grabic
The aim of this study was to develop a reliable analytical method for the measurement of 17 selected progestogens in waste water and surface water. Automated whole water solid phase extraction (SPE) was used for sample concentration. Liquid chromatography tandem atmospheric pressure chemical ionization/atmospheric pressure photoionization with hybrid quadrupole/orbital trap mass spectrometry operated in high resolution product scan mode (LC-APCI/APPI-HRPS) was applied for the analyses. The whole-method recoveries ranged from 60% to 140% for all analytes at two different spike levels (5 and 50ng/L) in the studied matrices...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29100665/sex-steroid-receptors-prostaglandin-e2-receptors-and-cyclooxygenase-in-the-equine-cervix-during-estrus-diestrus-and-pregnancy-gene-expression-and-cellular-localization
#19
Claudia B Fernandes, Shavahn C Loux, Kirsten E Scoggin, Edward L Squires, Mats H Troedsson, Alejandro Esteller-Vico, Barry A Ball
The cervix is a dynamic structure that undergoes dramatic changes during the estrous cycle, pregnancy and parturition. It is well established that hormonal changes, including estrogens, progestogens and prostaglandins, regulate the expression of key proteins involved in cervical function. The arachidonic acid cascade is important in the remodeling and relaxation of the cervix in the days preceding parturition. Despite the complexity of this mechanism, regulation of cervical function has received little study in the mare...
October 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29090375/ameliorative-effects-of-selenium-on-cadmium-induced-injury-in-the-chicken-ovary-mechanisms-of-oxidative-stress-and-endoplasmic-reticulum-stress-in-cadmium-induced-apoptosis
#20
Na Wan, Zhe Xu, Tianqi Liu, Yahong Min, Shu Li
Despite the well-established toxicity of cadmium (Cd) to animals and the ameliorative effects of selenium (Se), some specific mechanisms in the chicken ovary are not yet clarified. To explore the mechanism by which the toxicity effect of Cd is induced and explore the effect of supranutritional Se on Cd toxicity in female bird reproduction, forty-eight 50-day-old Isa Brown female chickens were divided randomly into four groups. Group I (control group) was fed the basic diet containing 0.2 mg/kg Se. Group II (Se-treated group) was fed the basic diet supplemented with sodium selenite (Na2SeO3), and the total Se content was 2 mg/kg...
October 31, 2017: Biological Trace Element Research
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