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https://www.readbyqxmd.com/read/28919450/seasonal-expression-of-p450c17-and-5%C3%AE-reductase-2-in-the-scented-gland-of-male-muskrats-ondatra-zibethicus
#1
Wentao Han, Wenqian Xie, Yan Zhang, Fengwei Zhang, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng
Cytochrome P450 17A1 (P450c17) is the key enzyme required for the production of androgenic sex steroids by converting progestogens to androgens. 5α-reductases are enzymes that convert testosterone (T) to dihydrotestosterone (DHT), which has a greater affinity for androgen receptors (AR) and stronger action than T. Our previous studies revealed that the scented glands of male muskrats expressed AR during the breeding and nonbreeding seasons. To further seek evidence of the activities of androgens in scented glands, the expression patterns of P450c17 and 5α-reductase 2 were investigated in the scented glands of male muskrats during the breeding and nonbreeding seasons...
September 14, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28919028/resumption-of-ovarian-function-the-metabolic-profile-and-body-condition-in-brahman-cows-bos-indicus-is-not-affected-by-the-combination-of-calf-separation-and-progestogen-treatment
#2
Ramiro Díaz, Carlos S Galina, Ivette Rubio, Manuel Corro, José Luis Pablos, Ana Rodríguez, Agustín Orihuela
To evaluate the effect of different calf separation procedures after a progestogen treatment on the resumption of ovarian function, body condition and metabolic profile, 59 multiparous Brahman cows grazing on a mixed grass pasture were studied. No supplementation was given at any time. Body condition score (BCS), fat thickness (FAT) and blood metabolites were measured fortnightly from the beginning of the last trimester of gestation until 96days postpartum. At 30days postpartum all animals received a progesterone (P4)-releasing device (CIDR) which was withdrawn 9days later when prostaglandin F2α was applied...
September 1, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28918829/awareness-of-individual-cardiovascular-risk-factors-and-self-perception-of-cardiovascular-risk-in-women
#3
Jean-Jacques Monsuez, Tai Pham, Nicole Karam, Laurence Amar, Corinne Chicheportiche-Ayache, Philippe Menasché, Michel Desnos, Paul Dardel, Isabelle Weill
BACKGROUND: Cardiovascular risk factors (CVRFs) self-perception by women may be inaccurate. MATERIALS AND METHODS: A questionnaire was completed anonymously Online by women who self-reported their personal CVRF levels including age, weight, contraceptive use, menopausal status, smoking, diet and physical activities. Self-perceived risk was matched to actual cardiovascular risk according to the Framingham score. RESULTS: Among 5,240 young and middle-aged women with a high educational level, knowledge of personal CVRFs increased with age, from 51-90% for blood pressure (BP), 22-45% for blood glucose and 15-47% for blood cholesterol levels, between 30 and 65 years, respectively...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28915701/comparison-among-fertility-sparing-therapies-for-well-differentiated-early-stage-endometrial-carcinoma-and-complex-atypical-hyperplasia
#4
REVIEW
Qing Zhang, Gonghua Qi, Margaux J Kanis, Ruifen Dong, Baoxia Cui, Xingsheng Yang, Beihua Kong
OBJECTIVE: To compare fertility-sparing therapies including oral progestogens, hysteroscopic resection (HR), and the levonorgestrel- releasing intrauterine system (LNG-IUS) in achieving disease regression, recurrence and live birth rate in well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia(CAH). STUDY DESIGN: This was a meta-analysis of previous studies focus on the fertility-sparing therapy for well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia (CAH)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912152/distinct-effects-of-body-mass-index-and-waist-hip-ratio-on-risk-of-breast-cancer-by-joint-estrogen-and-progestogen-receptor-status-results-from-a-case-control-study-in-northern-and-eastern-china-and-implications-for-chemoprevention
#5
Fei Wang, Liyuan Liu, Shude Cui, Fuguo Tian, Zhimin Fan, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang, Hong Liang, Shu Wang, Hongchuan Jiang, Xuening Duan, Haibo Wang, Guolou Li, Qitang Wang, Jianguo Zhang, Feng Jin, Jinhai Tang, Liang Li, Shiguang Zhu, Wenshu Zuo, Zhongbing Ma, Fei Zhou, Lixiang Yu, Yujuan Xiang, Liang Li, Shuohao Shen, Zhigang Yu
BACKGROUND: Obesity is a consideration in the pharmacologic intervention for estrogen receptor (ER) positive (ER+) breast cancer risk. Body mass index (BMI) and waist/hip ratio (WHR) have demonstrated different effects on breast cancer risk in relation to estrogen receptor (ER) status, but the results have been inconsistent. Furthermore, the situation in Chinese women remains unclear. MATERIALS AND METHODS: We conducted a case-control study including 1,439 breast cancer cases in Northern and Eastern China...
September 14, 2017: Oncologist
https://www.readbyqxmd.com/read/28911854/resumption-of-ovarian-function-the-metabolic-profile-and-body-condition-in-brahman-cows-bos-indicus-is-not-affected-by-the-combination-of-calf-separation-and-progestogen-treatment
#6
Ramiro Díaz, Carlos S Galina, Ivette Rubio, Manuel Corro, José Luis Pablos, Ana Rodríguez, Agustín Orihuela
To evaluate the effect of different calf separation procedures after a progestogen treatment on the resumption of ovarian function, body condition and metabolic profile, 59 multiparous Brahman cows grazing on a mixed grass pasture were studied. No supplementation was given at any time. Body condition score (BCS), fat thickness (FAT) and blood metabolites were measured fortnightly from the beginning of the last trimester of gestation until 96days postpartum. At 30days postpartum all animals received a progesterone (P4)-releasing device (CIDR) which was withdrawn 9days later when prostaglandin F2α was applied...
October 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28870155/pessary-or-progesterone-to-prevent-preterm-delivery-in-women-with-short-cervical-length-the-quadruple-p-randomised-controlled-trial
#7
Maud D van Zijl, Bouchra Koullali, Christiana A Naaktgeboren, Ewoud Schuit, Dick J Bekedam, Etelka Moll, Martijn A Oudijk, Wilhelmina M van Baal, Marjon A de Boer, Henricus Visser, Joris van Drongelen, Flip W van de Made, Karlijn C Vollebregt, Moira A Muller, Mireille N Bekker, Jozien T J Brons, Marieke Sueters, Josje Langenveld, Maureen T Franssen, Nico W Schuitemaker, Erik van Beek, Hubertina C J Scheepers, Karin de Boer, Eveline M Tepe, Anjoke J M Huisjes, Angelo B Hooker, Evelyn C J Verheijen, Dimitri N Papatsonis, Ben Willem J Mol, Brenda M Kazemier, Eva Pajkrt
BACKGROUND: Preterm birth is in quantity and in severity the most important topic in obstetric care in the developed world. Progestogens and cervical pessaries have been studied as potential preventive treatments with conflicting results. So far, no study has compared both treatments. METHODS/DESIGN: The Quadruple P study aims to compare the efficacy of vaginal progesterone and cervical pessary in the prevention of adverse perinatal outcome associated with preterm birth in asymptomatic women with a short cervix, in singleton and multiple pregnancies separately...
September 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28869284/ultra-performance-liquid-chromatography-tandem-mass-spectrometry-assay-for-determination-of-plasma-nomegestrol-acetate-and-estradiol-in-healthy-postmenopausal-women
#8
Sneha G Nair, Daxesh P Patel, Mallika Sanyal, Puran Singhal, Pranav S Shrivastav
A highly sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry method is described for the simultaneous determination of nomegestrol acetate (NOMAC), a highly selective progestogen, and estradiol (E2), a natural estrogen in human plasma. NOMAC was obtained from plasma by solid phase extraction, while E2 was first separated by liquid-liquid extraction with methyl tert-butyl ether followed by derivatization with dansyl chloride. Deuterated internal standards, NOMAC-d5 and E2-d4 were used for better control of extraction conditions and ionization efficiency...
September 4, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28863005/hiv-and-contraception
#9
Wing K Fok, Paul D Blumenthal
PURPOSE OF REVIEW: Contraception is a vital component of medical care for women with HIV or at high risk of acquiring HIV. Over the last several years, there has been emerging evidence regarding the safety and effectiveness of various contraceptive methods, ultimately leading to a revision in the WHO Medical Eligibility Criteria for contraceptive use. RECENT FINDINGS: Progestogen-only injectables may be associated with an increased risk of HIV acquisition and its use has been revised to category 2 from category 1...
August 31, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28835399/a-case-control-study-of-hormonal-exposures-as-etiologic-factors-for-als-in-women-euro-motor
#10
James P K Rooney, Anne E Visser, Fabrizio D'Ovidio, Roel Vermeulen, Ettore Beghi, Adriano Chio, Jan H Veldink, Giancarlo Logroscino, Leonard H van den Berg, Orla Hardiman
OBJECTIVE: To investigate the role of hormonal risk factors for amyotrophic lateral sclerosis (ALS) among women from 3 European countries. METHODS: ALS cases and matched controls were recruited over 4 years in Ireland, Italy, and the Netherlands. Hormonal exposures, including reproductive history, breastfeeding, contraceptive use, hormonal replacement therapy, and gynecologic surgical history, were recorded with a validated questionnaire. Logistic regression models adjusted for age, education, study site, smoking, alcohol, and physical activity were used to determine the association between female hormones and ALS risk...
August 23, 2017: Neurology
https://www.readbyqxmd.com/read/28828894/correction-to-leeaunkulsathean-et%C3%A2-al-the-effect-of-different-progestogens-on-sleep-in-postmenopausal-women-a-randomized-trial
#11
(no author information available yet)
No abstract text is available yet for this article.
August 22, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28801053/cervical-mucus-and-contraception-what-we-know-and-what-we-don-t
#12
REVIEW
Leo Han, Rebecca Taub, Jeffrey T Jensen
The properties of cervical mucus vary in response to both natural and artificial hormonal changes. During ovulatory cycles, cervical mucus becomes increasingly fluid and favorable to sperm penetration as estradiol levels increase. Following ovulation, as estradiol levels decrease and progesterone increases, the mucus increases in viscosity and becomes impenetrable to sperm. Cervical mucus thickening also occurs in response to synthetic progestins administered by various routes, and this is commonly believed to represent the essential contraceptive mechanism of progestin-only methods that do not block ovulation...
August 8, 2017: Contraception
https://www.readbyqxmd.com/read/28796699/serum-uric-acid-levels-and-hormone-therapy-type-a-retrospective-cohort-study-of-postmenopausal-women
#13
Jae H Jung, Gwan G Song, Young H Lee, Jae-Hoon Kim, Myung H Hyun, Sung J Choi
OBJECTIVE: Serum uric acid levels increase in postmenopausal women, but decrease when hormone therapy (HT) is administered. No study has, however, evaluated the effects of different types of HT on serum uric acid levels. We therefore examined whether estrogen therapy (ET), estrogen plus progestogen therapy (EPT), and tibolone use affected serum uric acid levels in this population. METHODS: We performed a retrospective cohort study of postmenopausal women. From 2005 to 2015, postmenopausal women who had undergone blood uric acid-level testing at least twice were enrolled...
August 7, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28783906/three-classes-of-steroids-in-typical-freshwater-aquaculture-farms-comparison-to-marine-aquaculture-farms
#14
Shan Liu, Hui Chen, Xiang-Rong Xu, Qin-Wei Hao, Jian-Liang Zhao, Guang-Guo Ying
This study provides a comprehensive analysis of the occurrence of androgens, glucocorticoids and progestogens in typical freshwater aquaculture farms in comparison with marine aquaculture farms. The results showed that more steroids were detected in the marine aquaculture farms. For all aquatic products, the total concentrations of steroids in fish muscle were 22-2000ng/g, which were much higher than those detected in crabs, shrimps or mollusks (0.5-8.1ng/g). Based on the hazard index of the selected steroids, most water samples were in the low or medium risks...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28771934/personalized-medicine-the-potential-yet-realized
#15
John O'Brien
The complex interactions between genes and the environment yield multiple pathophysiologies for the great obstetrical diseases such as preterm birth (Romero R et al, Science, 2014, 345,760-765). Our current, limited capacity to define when and to what extent any number of these pathophysiologies are in effect in individual pregnant patients has resulted in therapeutic strategies being aimed preferentially toward populations defined by risk factors, particularly obstetrical history. However, strategies such as prophylactic progestogen administration indicated for a prior preterm birth necessarily overtreat pregnant women exposing them and their children to potential, possibly unforeseen, harm (O'Brien JM, BJOG 2015;122:610-614)...
August 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28760491/effects-of-tibolone-on-fibrinogen-and-antithrombin-iii-a-systematic-review-and-meta-analysis-of-controlled-trials
#16
Małgorzata Bała, Amirhossein Sahebkar, Sorin Ursoniu, Maria-Corina Serban, Anetta Undas, Dimitri P Mikhailidis, Gregory Y H Lip, Jacek Rysz, Maciej Banach
Tibolone is a synthetic steroid with estrogenic, androgenic and progestogenic activity, but the evidence regarding its effects on fibrinogen and antithrombin III (ATIII) has not been conclusive. We assessed the impact of tibolone on fibrinogen and ATIII through a systematic review and meta-analysis of available randomized controlled trials (RCTs). The search included PUBMED, Web of Science, Scopus, and Google Scholar (up to January 31st, 2016) to identify controlled clinical studies investigating the effects of oral tibolone treatment on fibrinogen and ATIII...
October 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28759835/characterizing-the-reproductive-biology-of-the-female-pygmy-hippopotamus-choeropsis-liberiensis-through-non-invasive-endocrine-monitoring
#17
Gabriella L Flacke, Franz Schwarzenberger, Linda M Penfold, Susan L Walker, Graeme B Martin, Robert Peter Millar, Monique C J Paris
The pygmy hippopotamus (Choeropsis liberiensis) is endangered in the wild and very little is known about its reproductive biology. In zoological facilities, this species experiences a number of reproductive issues that complicate breeding management, including a high rate of stillbirths and failure of many pairs to reproduce. We conducted a comprehensive study to evaluate reproductive cycles and pregnancy in this species using enzyme immunoassays (EIAs) for fecal hormone metabolite analysis. Fresh fecal samples were collected twice weekly for a one to three year period from 36 female pygmy hippos housed at 24 zoological institutions...
July 19, 2017: Theriogenology
https://www.readbyqxmd.com/read/28732252/update-on-medical-treatment-of-uterine-fibroids
#18
REVIEW
Fátima Faustino, Margarida Martinho, José Reis, Fernanda Águas
OBJECTIVES: In this review paper, the pros and cons of the available pharmacological options for the treatment of uterine fibroids are explored, including oral progestogens, levonorgestrel intra-uterine device, gonadotropin-releasing hormone analogs and progesterone receptor modulators with an emphasis on ulipristal acetate. STUDY DESIGN: The choice of the appropriate therapeutic approach for uterine fibroids depends on several factors, including women's age, parity, childbearing aspirations and wish to preserve fertility, extent and severity of symptoms, size, number and location of myomas, risk of malignancy and proximity to menopause...
September 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28697460/effect-of-progesterone-and-its-synthetic-analogs-on-reproduction-and-embryonic-development-of-a-freshwater-invertebrate-model
#19
Zita Zrinyi, Gabor Maasz, Linwen Zhang, Akos Vertes, Sandor Lovas, Tibor Kiss, Karoly Elekes, Zsolt Pirger
The presence of a mixture of progestogens at ng/L concentration levels in surface waters is a worldwide problem. Only a few studies explore the effect of progestogen treatment in a mixture as opposed to individual chemicals to shed light on how non-target species respond to these contaminants. In the present study, we used an invertebrate model species, Lymnaea stagnalis, exposed to a mixture of four progestogens (progesterone, levonorgestrel, drospirenone, and gestodene) in 10ng/L concentration for 3 weeks...
September 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28697036/comparison-of-clinical-outcomes-among-users-of-oral-and-transdermal-estrogen-therapy-in-the-women-s-health-initiative-observational-study
#20
Carolyn J Crandall, Kathleen M Hovey, Christopher Andrews, Jane A Cauley, Marcia Stefanick, Chrisandra Shufelt, Ross L Prentice, Andrew M Kaunitz, Charles Eaton, Jean Wactawski-Wende, JoAnn E Manson
OBJECTIVE: To examine associations of estrogen preparations with an index of health risks versus benefits. METHODS: Using data from 45,112 participants of the Women's Health Initiative Observational Study (average follow-up 5.5 years), we examined associations of estrogen type and oral conjugated equine estrogen (CEE) dose with time to first global index event (GIE), defined as coronary heart disease, breast cancer, stroke, pulmonary embolism, hip fracture, colorectal cancer, endometrial cancer, or death...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
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