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https://www.readbyqxmd.com/read/29790381/what-do-tsecs-provide-in-the-menopausal-hormone-therapy
#1
Placido Llaneza, Joaquim Calaf, Ana Rosa Jurado, Nicolas Mendoza, Borja Otero, Francisco Quereda, Rafael Sánchez-Borrego, Daniel Lubian
Tissue-selective estrogen complex (TSEC) is projected as a progestogen-free option for the treatment of estrogen deficiency symptoms in postmenopausal, non-hysterectomized women. TSEC combines the benefits of estrogen with a selective estrogen receptor modulator (SERM), in this case bazedoxifene acetate (BZA), which has an antagonistic effect on the endometrium, thus avoiding the use of progestins. The authorized TSEC combination (conjugated estrogens [CE] 0.45 mg/BZA 20 mg) for the alleviation of vasomotor symptoms has been demonstrated in randomized clinical trials compared with placebo or menopausal hormone therapy (MHT)...
May 23, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29778442/developmental-profiles-of-progesterone-receptor-transcripts-and-molecular-responses-to-gestagen-exposure-during-silurana-tropicalis-early-development
#2
Paisley Thomson, Valerie S Langlois
Environmental gestagens are an emerging class of contaminants that have been recently measured in surface water and can interfere with reproduction in aquatic vertebrates. Gestagens include endogenous progestogens, such as progesterone (P4), which bind P4-receptors and have critically important roles in vertebrate physiology and reproduction. Gestagens also include synthetic progestins, which are components of human and veterinary drugs, such as melengestrol acetate (MGA). Endogenous progestogens are essential in the regulation of reproduction in mammalian species, but the role of P4 in amphibian larval development remains unclear...
May 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29769477/enzyme-immunoassays-for-water-soluble-steroid-metabolites-in-the-urine-and-feces-of-japanese-macaques-macaca-fuscata-using-a-simple-elution-method
#3
Keiko Shimizu, Keiko Mouri
A simple, non-alcoholic extraction method for measuring estrogen and progesterone metabolites in excreta using enzyme immunoassays (EIAs) was developed in Japanese macaques. The obtained detection limits of EIAs using estrone conjugates (E1 C), pregnanediol glucuronide (PdG), and estriol glucuronide (E3 G) polyclonal antibodies with cross-reactivity to urinary and fecal steroid metabolites were 6.6 pg/ml, 2.1 ng/ml, and 0.35 ng/ml, respectively. These assays allowed the determination of E1 C, PdG, and E3 G from the excreta with good reproducibility and accuracy...
May 17, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29764430/drug-prescribing-during-pregnancy-in-a-central-region-of-italy-2008-2012
#4
Martina Ventura, Alice Maraschini, Paola D'Aloja, Ursula Kirchmayer, Ilaria Lega, Marina Davoli, Serena Donati
BACKGROUND: Drug consumption during pregnancy is a matter of concern, especially regarding drugs known or suspected to be teratogens. Little is known about drug use in pregnant women in Italy. The present study is aimed at examining the prevalence, and to detect potential inappropriateness of drug prescribing among pregnant women in Latium, a region of central Italy. METHODS: This retrospective study was conducted on a cohort of women aged 18-45 years who delivered between 2008 and 2012 in public hospitals...
May 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29763969/hormone-replacement-therapy-for-women-previously-treated-for-endometrial-cancer
#5
REVIEW
Katharine A Edey, Stuart Rundle, Martha Hickey
BACKGROUND: Endometrial cancer is the sixth most common cancer in women worldwide and most commonly occurs after the menopause (75%) (globocan.iarc.fr). About 319,000 new cases were diagnosed worldwide in 2012. Endometrial cancer is commonly considered as a potentially 'curable cancer,' as approximately 75% of cases are diagnosed before disease has spread outside the uterus (FIGO (International Federation of Gynecology and Obstetrics) stage I). The overall five-year survival for all stages is about 86%, and, if the cancer is confined to the uterus, the five-year survival rate may increase to 97%...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29734624/the-consequences-of-exposure-to-mixtures-of-chemicals-something-from-nothing-and-a-lot-from-a-little-when-fish-are-exposed-to-steroid-hormones
#6
Tara J Thrupp, Tamsin J Runnalls, Martin Scholze, Subramaniam Kugathas, Andreas Kortenkamp, John P Sumpter
Ill-defined, multi-component mixtures of steroidal pharmaceuticals are present in the aquatic environment. Fish are extremely sensitive to some of these steroids. It is important to know how fish respond to these mixtures, and from that knowledge develop methodology that enables accurate prediction of those responses. To provide some of the data required to reach this objective, pairs of fish were first exposed to five different synthetic steroidal pharmaceuticals (one estrogen, EE2; one androgen, trenbolone; one glucocorticoid, beclomethasone dipropionate; and two progestogens, desogestrel and levonorgestrel) and concentration-response data on egg production obtained...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29709317/estrus-suppression-in-dogs
#7
REVIEW
Michelle Anne Kutzler
Since 1952, scientists have studied estrus suppression in dogs. Estrus suppression in dogs must be safe and reliable. Medications used for estrus suppression in bitches include gonadotropin-releasing hormone (GnRH) agonists, GnRH antagonists, progestogens, and androgens. Despite widespread availability of these medications throughout the rest of the world, there are no drugs currently labeled for canine estrus induction in the United States.
April 27, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29701828/sex-bias-of-the-birth-litter-affects-surge-but-not-tonic-lh-secretion-in-gilts
#8
J Seyfang, R N Kirkwood, A J Tilbrook, C R Ralph
The physiology and behaviour of gilts that develop in a male biased litter can differ from gilts that develop in a female biased litter. We hypothesized that gilts from male biased litters will have a delayed and attenuated LH surge, and reduced LH pulse frequency and amplitude compared to gilts from female biased litters. Gilts were selected at birth from male biased (> 60 % males n = 10) or female biased (> 60 % females n = 9) litters. From 18 weeks of age, detection of puberty using daily boar contact began and their subsequent estrous periods were synchronized with oral progestogen (altrenogest)...
April 26, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29688280/the-occurrence-of-benign-brain-tumours-in-transgender-individuals-during-cross-sex-hormone-treatment
#9
Nienke M Nota, Chantal M Wiepjes, Christel J M de Blok, Louis J G Gooren, Saskia M Peerdeman, Baudewijntje P C Kreukels, Martin den Heijer
Benign brain tumours may be hormone sensitive. To induce physical characteristics of the desired gender, transgender individuals often receive cross-sex hormone treatment, sometimes in higher doses than hypogonadal individuals. To date, long-term (side) effects of cross-sex hormone treatment are largely unknown. In the present retrospective chart study we aimed to compare the incidence of common benign brain tumours: meningiomas, pituitary adenomas (non-secretive and secretive), and vestibular schwannomas in transgender individuals receiving cross-sex hormone treatment, with those reported in general Dutch or European populations...
April 23, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29684377/biphasic-modulation-of-camp-levels-by-the-contraceptive-nomegestrol-acetate-impact-on-p-glycoprotein-expression-and-activity-in-hepatic-cells
#10
Guillermo Nicolás Tocchetti, Camila Juliana Domínguez, Felipe Zecchinati, Maite Rocío Arana, María Laura Ruiz, Silvina Stella Maris Villanueva, Johanna Weiss, Aldo Domingo Mottino, Juan Pablo Rigalli
ABC transporters are key players in drug excretion with alterations in their expression and activity by therapeutic agents potentially leading to drug-drug interactions. The interaction potential of nomegestrol acetate (NMGA), a synthetic progestogen increasingly used as oral contraceptive, had never been explored. In this work we evaluated (1) the effect of NMGA on ABC transporters in the human hepatic cell line HepG2 and (2) the underlying molecular mechanism. NMGA (5, 50 and 500 nM) increased P-glycoprotein (P-gp) expression at both protein and mRNA levels and reduced intracellular calcein accumulation, indicating an increase also in transporter activity...
April 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29662684/a-comparison-of-combined-oral-contraceptives-containing-chlormadinone-acetate-versus-drospirenone-for-the-treatment-of-acne-and-dysmenorrhea-a-randomized-trial
#11
Unnop Jaisamrarn, Somsook Santibenchakul
Background: Oral contraceptives (OCs), aside from contraceptive efficacy, have been widely known for their non-contraceptive benefits. Different progestogens component of the OCs have been shown to improve the skin, hair, menstrual cycle related disorders and dysmenorrhoeic pain. Thus, we compared the efficacy of OCs containing ethinyl estradiol (EE) and chlormadinone acetate (CMA) versus OCs containing EE and drospirenone (DRSP) for the treatment of acne and dysmenorrhea. Methods: This study was an investigator-blinded, randomized, parallel group study conducted at the Family Planning Clinic, Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand...
2018: Contraception and Reproductive Medicine
https://www.readbyqxmd.com/read/29656433/antifibrinolytics-for-heavy-menstrual-bleeding
#12
REVIEW
Alison C Bryant-Smith, Anne Lethaby, Cindy Farquhar, Martha Hickey
BACKGROUND: Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase the risk of venous thromboembolic disease. This is an umbrella term for deep venous thrombosis (blood clots in the blood vessels in the legs) and pulmonary emboli (blood clots in the blood vessels in the lungs)...
April 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29648645/does-human-endometrial-lgr5-gene-expression-suggest-the-existence-of-another-hormonally-regulated-epithelial-stem-cell-niche
#13
N Tempest, A M Baker, N A Wright, D K Hapangama
STUDY QUESTION: Is human endometrial leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) gene expression limited to the postulated epithelial stem cell niche, stratum basalis glands, and is it hormonally regulated? SUMMARY ANSWER: LGR5 expressing cells are not limited to the postulated stem cell niche but LGR5 expression is hormonally regulated. WHAT IS KNOWN ALREADY: The human endometrium is a highly regenerative tissue; however, endometrial epithelial stem cell markers are yet to be confirmed...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29627127/the-action-of-estrogens-and-progestogens-in-the-young-female-breast
#14
Irene Zolfaroli, Juan J Tarín, Antonio Cano
Evidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes. Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the changes being observed across mammalian species, including humans. Estrogen receptors, and more particularly the alpha isoform, participate in molecular processes of stem cells differentiation and epithelial proliferation through paracrine actions implicating growth factors...
March 28, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29617576/current-understanding-on-pharmacokinetics-clinical-efficacy-and-safety-of-progestins-for-treating-pain-associated-to-endometriosis
#15
Fabio Barra, Carolina Scala, Simone Ferrero
Introduction Endometriosis is a chronic estrogen and progestogen responsive inflammatory disease associated with pain symptoms and infertility. The medical therapy of endometriosis aims to induce decidualization within the hormonally dependent ectopic endometrium, and it is often administered to ameliorate women' pain symptoms or to prevent post-surgical disease recurrence. A variety of progestins have been used in monotherapy for the medical management of women with endometriosis. Areas covered This review aims to offer the reader a complete overview of pharmacokinetic (PK) and clinical efficacy of progestins for the treatment of endometriosis...
April 4, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29615037/identification-of-new-progestogen-associated-networks-in-mammalian-ovulation-using-bioinformatics
#16
Fang Yang, Meng Wang, Baoyun Zhang, Wei Xiang, Ke Zhang, Mingxin Chu, Pingqing Wang
BACKGROUND: Progesterone plays an essential role in mammalian ovulation. Although much is known about this process, the gene networks involved in ovulation have yet to be established. When analyze the mechanisms of ovulation, we often need to determine key genes or pathways to investigate the reproduction features. However, traditional experimental methods have a number of limitations. RESULTS: Data, in this study, were acquired from GSE41836 and GSE54584 which provided different samples...
April 3, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29614278/progestogens-in-singleton-gestations-with-preterm-prelabor-rupture-of-membranes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
Johanna Quist-Nelson, Pamela Parker, Neggin Mokhtari, Rossana Di Sarno, Gabriele Saccone, Vincenzo Berghella
BACKGROUND: Preterm prelabor rupture of membranes (PROM) occurs in 3% of all pregnancies. Neonatal benefit is seen in uninfected women that do not deliver immediately after preterm PROM. OBJECTIVE: To evaluate if administration of progestogens in singleton pregnancies prolongs pregnancy after preterm PROM. STUDY DESIGN: Searches were performed in MEDLINE, OVID, Scopus, EMBASE, ClinicalTrials.gov and the Cochrane Central Register of Controlled Trials with the use of a combination of keywords and text words related to "progesterone," "progestogen," "prematurity" and "preterm premature rupture of membranes" from inception of databases until January 2018...
March 31, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29613885/hormone-therapy-in-menopausal-women-with-fibroids-is-it-safe
#18
Vedhapriya Srinivasan, Mark G Martens
Menopause is an important transition in the life of women. It has been estimated that by the year 2030, worldwide 1.2 billion women will be menopausal. The most bothersome symptoms of menopause are believed to be due to declines in estrogen levels in postmenopausal women. Thus, hormone therapy is an effective treatment option for menopausal women, although prolonged use of hormone therapy is associated with a slightly increased risk of breast cancer, thromboembolism, and stroke. A literature search for studies evaluating the effects of hormone therapy in menopausal women with asymptomatic fibroids demonstrated variable effects of hormone therapy on the volume and size of the fibroids...
April 2, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29609766/dienogest-suppresses-the-activation-of-primordial-follicles-and-preserves-the-primordial-follicle-stockpile-for-fertility-in-mice
#19
Luyi Zheng, Fuminori Kimura, Di Wu, Aina Morimune, Yoko Niwa, Shizuka Mita, Kentaro Takahashi, Takashi Murakami
The aim of the present study was to characterize the effect of long-term usage of dienogest, a fourth-generation progestin that possesses progestogen and anti-androgen activities, on the stockpile of oocytes and fertility after administration. Female ICR mice (100 days old) were divided into a dienogest group and a control group. The mice received 16 consecutive subcutaneous injections of 5 mg dienogest dissolved in corn oil or corn oil as a vehicle control every 4 days. The mice treated with dienogest had more total offspring and larger litter sizes after the final administration than the mice treated with the vehicle control...
April 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29599988/contraceptives-as-possible-risk-factors-for-postpartum-depression-a-retrospective-study-of-the-food-and-drug-administration-adverse-event-reporting-system-2004-2015
#20
Megumi Horibe, Yuuki Hane, Junko Abe, Toshinobu Matsui, Yamato Kato, Natsumi Ueda, Sayaka Sasaoka, Yumi Motooka, Haruna Hatahira, Shiori Hasegawa, Yasutomi Kinosada, Hideaki Hara, Mitsuhiro Nakamura
Aim: Postpartum depression is a mood disorder that commonly affects women during the early postpartum period. The objective of this study was to analyse the association of postpartum depression with drugs (including contraceptive devices and implants) with spontaneously reported adverse events reported in the US Food and Drug Administration Adverse Event Reporting System database. Design: Retrospective study. Method: Reports of postpartum depression events between 2004-2015 were analysed with a reporting odds ratio (ROR) algorithm...
April 2018: Nursing Open
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