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Jennifer S Gewandter, Rachel A Kitt, Matthew R Hunsinger, Joseph Poku, Jacqueline Lozano, Jenna Chaudari, Scott Evans, Robert A Gross, Michael P McDermott, Michael C Rowbotham, Dennis C Turk, Robert H Dworkin
OBJECTIVE: To examine whether primary reports of randomized clinical trials (RCTs) in six high-impact, general medical journals reported (1) whether or not a Data Monitoring Committee/Data and Safety Monitoring Board (DMC/DSMB) was used and (2) the composition of the responsibilities of the reported DSMB/DMCs. STUDY DESIGN AND SETTING: Systematic review of RCTs published in 2014 in Annals of Internal Medicine, BMJ, NEJM, JAMA, JAMA Internal Medicine, and Lancet...
January 23, 2017: Journal of Clinical Epidemiology
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
December 2016: Quality of Life Research
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of data monitoring committees (DMCs), the frequency of interim analysis, prespecified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high-impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
January 2017: Acta Paediatrica
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2015: New England Journal of Medicine
Anthony J Scillia, James D McDermott, Kimona Issa, Peter Goljan, Steven F Harwin, Anthony Festa, Vincent K McInerney
Arthroscopic partial meniscectomy (APM) has been demonstrated to be effective when performed in the appropriately indicated patient. However, a recent study published in the New England Journal of Medicine (NEJM) questioned whether or not the procedure actually had any clinical benefit whatsoever. Despite being a prospective, Level 1, randomized study, there are several aspects of the study that must be taken into consideration when interpreting the findings, including but not limited to the patient selection criteria, limited sample size, and lack of information regarding meniscal tear patterns...
July 2016: Journal of Knee Surgery
(no author information available yet)
Pandemic Preparedness and Response - Lessons from the H1N1 Influenza of 2009 Review Article, N Engl J Med 2014;370:1335-1342. In the "Time Course of the 2009 H1N1 Pandemic" section, in the first paragraph under "World Health Organization" (page 1337), the third sentence should have begun, "The organization provided guidance to inform national influenza-preparedness plans, which were in place in 74% of countries . . ." rather than, ". . . in 74 countries . . . ." The article is correct at
January 8, 2015: New England Journal of Medicine
(no author information available yet)
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease Review Article, N Engl J Med 2014;371:1131-1141. In the legend for Figure 2 (page 1134), the third sentence should have read, "Activated PKCε binds to and inhibits the insulin receptor tyrosine kinase, leading to decreased insulin-stimulated glycogen synthesis in the liver owing to decreased phosphorylation of GSK3," rather than ". . . leading to decreased insulin-stimulated glycogen synthesis in the liver through increased glycogen synthase kinase 3 (GSK3) phosphorylation...
December 4, 2014: New England Journal of Medicine
V Krishnan, D Kejariwal
INTRODUCTION: Medical 'ward round' (WR) is a complex clinical process and a key component of daily hospital activity. Despite this, there is a clear paucity of quality indicators and evidence base for best practice for WR with considerable variability in the efficiency and quality. This prompted us to devise and implement a ward round checklist (WRC)based on the Royal College of Physicians (RCP) and Nursing (RCN) ([1]) to improve quality of inpatient care. METHODS: We developed the WRC (Figure 1) for a comprehensive patient review, got approved by the hospital health records committee and used as a sticky note in clinical notes...
June 2014: Gut
(no author information available yet)
Severe Sepsis and Septic Shock Review Article, N Engl J Med 2013;369:840-851. In Table 2 (page 846), the grade given for "Continue fluid-challenge technique as long as there is hemodynamic improvement" (row 6 under Resuscitation) should have been UG, rather than 1C. The article is correct at
November 21, 2013: New England Journal of Medicine
(no author information available yet)
Enteropathogens and Chronic Illness in Returning Travelers Review Article, N Engl J Med 2013;368:1817-1825. In Table 1 (page 1819), the images for Entamoeba histolytica and Strongyloides were transposed. The article is correct at
May 9, 2013: New England Journal of Medicine
E Kuhn, N Binart, M Lombès
Three articles published in the NEJM in 2009 have renewed the interest for brown adipose tissue (BAT) in humans. This review reports interesting new findings on adipocyte cell types that have been presented at the last meeting of the Endocrine Society in Houston, TX, in June 2012. Many studies have focused on identifying factors involved in brown adipocyte lineage, the site of adaptive thermogenesis. Indeed, the role of the transcription factors, such as PRDM16, in brown adipocyte differentiation has been unambiguously established...
October 2012: Annales D'endocrinologie
Konstantinos C M Siontis, Evangelos Evangelou, John P A Ioannidis
BACKGROUND: Prestigious journals select for publication studies that are considered most important and informative. We aimed to examine whether high-impact general (HIG) medical journals systematically demonstrate more favourable results for experimental interventions compared with the rest of the literature. METHODS: We scrutinized systematic reviews of the Cochrane Database (Issue 4, 2009) and meta-analyses published in four general journals (2008-09). Eligible articles included ≥1 binary outcome meta-analysis(es) pertaining to effectiveness with ≥1 clinical trial(s) published in NEJM, JAMA or Lancet...
October 2011: International Journal of Epidemiology
P O Erah, P A Aghayere, I A Suleman, T P Osahon
BACKGROUND: Malaria is a major devastating infectious diseases in tropical countries. The resistance of P. falciparum to the traditional antimalarial drugs is believed to be contributing to increased malaria mortality. OBJECTIVE: The purpose of this study is to evaluate randomized clinical trials of uncomplicated P. faciparum malaria with the hope of providing recent scientific evidence on the current antimalarial drugs that would be effective, safe, affordable and available in Africa...
October 2010: Nigerian Quarterly Journal of Hospital Medicine
George C M Siontis, John P A Ioannidis
BACKGROUND: Large studies may identify postulated risk factors and interventions with very small effect sizes. We aimed to assess empirically a large number of statistically significant relative risks (RRs) of tiny magnitude and their interpretation by investigators. METHODS: RRs in the range between 0.95 and 1.05 were identified in abstracts of articles of cohort studies; articles published in NEJM, JAMA or Lancet; and Cochrane reviews. For each eligible tiny effect and the respective study, we recorded information on study design, participants, risk factor/intervention, outcome, effect estimates, P-values and interpretation by study investigators...
October 2011: International Journal of Epidemiology
Janice D Nunnelee
No abstract text is available yet for this article.
December 2009: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
Nicole B Gabler, Naihua Duan, Diana Liao, Joann G Elmore, Theodore G Ganiats, Richard L Kravitz
BACKGROUND: Some patients will experience more or less benefit from treatment than the averages reported from clinical trials; such variation in therapeutic outcome is termed heterogeneity of treatment effects (HTE). Identifying HTE is necessary to individualize treatment. The degree to which heterogeneity is sought and analyzed correctly in the general medical literature is unknown. We undertook this literature sample to track the use of HTE analyses over time, examine the appropriateness of the statistical methods used, and explore the predictors of such analyses...
June 19, 2009: Trials
Pamela S Ganschow, Elizabeth A Jacobs, Jennifer Mackinnon, Pamela Charney
INTRODUCTION: The aim of this clinical update is to summarize articles and guidelines published in the last year with the potential to change current clinical practice as it relates to women's health. METHODS: We used two independent search strategies to identify articles relevant to women's health published between March 1, 2007 and February 29, 2008. First, we reviewed the Cochrane Database of Systematic Reviews and journal indices from the ACP Journal Club, Annals of Internal Medicine, Archives of Internal Medicine, British Medical Journal, Circulation, Diabetes, JAMA, JGIM, Journal of Women's Health, Lancet, NEJM, Obstetrics and Gynecology, and Women's Health Journal Watch...
June 2009: Journal of General Internal Medicine
Marc E Levsky, Alex Rosin, Troy P Coon, William L Enslow, Michael A Miller
INTRODUCTION: The emphasis on publications for promotion in academic medicine would lead one to the theory that authorship numbers would increase proportionally with this emphasis. To investigate authorship trends across a number of periodicals, we performed a descriptive study comparing two full years of published articles spaced ten years apart from five medical journals. METHODS: Physician reviewers each reviewed all articles of one medical journal for the 1995 and 2005 publication years...
April 2007: Southern Medical Journal
Reshma Jagsi, Elizabeth A Guancial, Cynthia Cooper Worobey, Lori E Henault, Yuchiao Chang, Rebecca Starr, Nancy J Tarbell, Elaine M Hylek
BACKGROUND: Participation of women in the medical profession has increased during the past four decades, but issues of concern persist regarding disparities between the sexes in academic medicine. Advancement is largely driven by peer-reviewed original research, so we sought to determine the representation of female physician-investigators among the authors of selected publications during the past 35 years. METHODS: Original articles from six prominent medical journals--the New England Journal of Medicine (NEJM), the Journal of the American Medical Association (JAMA), the Annals of Internal Medicine (Ann Intern Med), the Annals of Surgery (Ann Surg), Obstetrics & Gynecology (Obstet Gynecol), and the Journal of Pediatrics (J Pediatr)--were categorized according to the sex of both the first and the senior (last listed) author...
July 20, 2006: New England Journal of Medicine
Bernard Lown, Amitava Banerjee
BACKGROUND: Rampant disease in poor countries impedes development and contributes to growing North-South disparities; however, leading international medical journals underreport on health research priorities for developing countries. METHODS: We examined 416 weekly issues of the New England Journal of Medicine (NEJM) over an eight-year period, January 1997 to December 2004. A total of 8857 articles were reviewed by both authors. The content of each issue was evaluated in six categories: research, review articles, editorial, correspondence, book reviews and miscellaneous...
2006: Globalization and Health
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