Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Tobi F Somerville, Shaffi Mdala, Thokozani Zungu, Moira Gandiwa, Rose Herbert, Dean Everett, Caroline E Corless, Nicholas A V Beare, Timothy Neal, Malcolm J Horsburgh, Alistair Darby, Stephen B Kaye, Petros C Kayange
OBJECTIVE: Microbial keratitis (MK) is a significant cause of blindness in sub-Saharan Africa. We investigated the feasibility of using a novel corneal impression membrane (CIM) for obtaining and processing samples by culture, PCR and whole-genome sequencing (WGS) in patients presenting with suspected MK in Malawi. METHODS AND ANALYSIS: Samples were collected from patients presenting with suspected MK using a 12 mm diameter polytetrafluoroethylene CIM disc. Samples were processed using culture and PCR for Acanthamoeba , herpes simplex virus type 1 (HSV-1) and the bacterial 16S rRNA gene...
April 22, 2024: BMJ Open Ophthalmology
#2
JOURNAL ARTICLE
Adam R Barno, Kevin Green, Forest Rohwer, Cynthia B Silveira
Algal blooms can give snowmelt a red color, reducing snow albedo and creating a runaway effect that accelerates snow melting. The occurrence of red snow is predicted to grow in polar and subpolar regions with increasing global temperatures. We hypothesize that these algal blooms affect virus-bacteria interactions in snow, with potential effects on snowmelt dynamics. A genomic analysis of double-stranded DNA virus communities in red and white snow from the Whistler region of British Columbia, Canada, identified 792 putative viruses infecting bacteria...
April 22, 2024: MSystems
#3
JOURNAL ARTICLE
Chunping Sun, Chaoe Zhou, Lina Wang, Shanchen Wei, Mingwei Shi, Jun Li, Lianjun Lin, Xinmin Liu
Metagenomic next-generation sequencing (mNGS) has become an available method for pathogen detection. The clinical application of mNGS requires further evaluation. We conducted a cross-sectional study of 104 patients with suspected infection between May 2019 and May 2021. The risk factors associated with infection were analyzed using univariate logistic analysis. The diagnostic performance of pathogens was compared between mNGS and conventional microbiological tests. About 104 patients were assigned into 3 groups: infected group (n = 69), noninfected group (n = 20), and unknown group (n = 15)...
April 19, 2024: Medicine (Baltimore)
#4
JOURNAL ARTICLE
Peter L Lenaker, Matthew A Pronschinske, Steven R Corsi, Joel P Stokdyk, Hayley T Olds, Deborah K Dila, Sandra L McLellan
Human sewage contaminates waterways, delivering excess nutrients, pathogens, chemicals, and other toxic contaminants. Contaminants and various sewage indicators are measured to monitor and assess water quality, but these analytes vary in their representation of sewage contamination and the inferences about water quality they support. We measured the occurrence and concentration of multiple microbiological (n = 21) and chemical (n = 106) markers at two urban stream locations in Milwaukee, Wisconsin, USA over two years...
April 16, 2024: Science of the Total Environment
#5
JOURNAL ARTICLE
Patoo Withatanung, Sujintana Janesomboon, Muthita Vanaporn, Veerachat Muangsombut, Sorujsiri Charoensudjai, Dave J Baker, Vanaporn Wuthiekanun, Edouard E Galyov, Martha R J Clokie, Ozan Gundogdu, Sunee Korbsrisate
Bacteriophages (phages), viruses that infect bacteria, are found in abundance not only in the environment but also in the human body. The use of phages for the diagnosis of melioidosis, a tropical infectious disease caused by Burkholderia pseudomallei , is emerging as a promising novel approach, but our understanding of conditions under which Burkholderia prophages can be induced remains limited. Here, we first demonstrated the isolation of Burkholderia phages from the hemocultures of melioidosis patients. The B...
2024: Frontiers in Microbiology
#6
JOURNAL ARTICLE
Yu Shuai, Xin Wang, Songli Chen, Tixue Huang, Zhao Wang, Yi Zhang
PURPOSE: The process of infection by bacteria and viruses involves invasion, establishment, growth, and parasitization. Poor oral hygiene and dysbiosis are significant risk factors for pneumonia. The aim of this study was to evaluate bacterial transport into the trachea during intubation for orthopedic surgery and the impact of oral hygiene treatment. METHODS: The study cohort included 53 patients with fracture who underwent surgical procedures under general anesthesia and were divided into two groups: an oral hygiene treatment (OHT) group (n = 27) and a control group (n = 26)...
2024: Journal of Oral Science
#7
JOURNAL ARTICLE
Wenli Ye, Jiaxuan Wu, Qiaozhi Jiang, Zhiheng Su, Haiqing Liao, Zhenmin Liu, Renchuan Tao, Xiangzhi Yong
Aim: To investigate the antibacterial effects of Corydalis Saxicola bunting total alkaloid (CSBTA) on Porphyromonas gingivalis . Methods: SEM, chemical staining, RT-qPCR and ELISA were used to detect effects of CSBTA on P. gingivalis . Results: CSBTA treatment caused shrinkage and rupture of P. gingivalis morphology, decreased biofilm density and live bacteria in biofilm, as well as reduced mRNA expression of virulence genes hagA , hagB , kgp , rgpA and rgpB of P. gingivalis . Furthermore, NOK cells induced by CSBTA-treated P...
April 17, 2024: Future Microbiology
#8
JOURNAL ARTICLE
Minh Ho, Huynh-Nga Nguyen, Minh Van Hoang, Tien Thuy Thi Bui, Bao-Quoc Vu, Truc Huong Thi Dinh, Hoa Thi My Vo, Diana C Blaydon, Sherif A Eldirany, Christopher G Bunick, Chi-Bao Bui
BACKGROUND: Congenital ichthyosis (CI) is a collective group of rare hereditary skin disorders. Patients present with epidermal scaling, fissuring, chronic inflammation, and increased susceptibility to infections. Recently, there is increased interest in the skin microbiome; therefore, we hypothesized that CI patients likely exhibit an abnormal profile of epidermal microbes because of their various underlying skin barrier defects. Among recruited individuals of Southeast Asian ethnicity, we performed skin meta-genomics (i...
April 16, 2024: Human Genomics
#9
JOURNAL ARTICLE
Jones Anderson Monteiro Siqueira, Dielle Monteiro Teixeira, Guilherme Junior Leite da Piedade, Cintya de Oliveira Souza, Tuane Carolina Ferreira Moura, Marcia de Nazaré Miranda Bahia, Danielle Murici Brasiliense, Denise Suéllen Amorim de Sousa Santos, Lena Lillian Canto de Sa Morais, Dorotéa de Fátima Lobato da Silva, Bruno Santana Carneiro, Kenny da Costa Pinheiro, Edivaldo Costa Sousa Junior, Clístenes Pamplona Catete, Ricardo José de Paula Souza E Guimarães, James Lima Ferreira, Wanderley Dias das Chagas Junior, Raiana Scerni Machado, Fernando Neto Tavares, Hugo Reis Resque, Patrícia Dos Santos Lobo, Sylvia de Fátima Dos Santos Guerra, Luana Silva Soares, Luciana Damascena da Silva, Yvone Benchimol Gabbay
AIMS: The present study aimed to use a conventional and metagenomic approach to investigate the microbiological diversity of water bodies in a network of drainage channels and rivers located in the central area of the city of Belém, Northern Brazil, which is considered one of the largest cities in the Brazilian Amazon. METHODS AND RESULTS: In eight of the analyzed points, both bacterial and viral microbiological indicators of environmental contamination, the physical-chemical and metals were assessed...
April 16, 2024: Journal of Applied Microbiology
#10
JOURNAL ARTICLE
Hong Hu, Anjian Li, Changyou Shi, Liang Chen, Zelong Zhao, Xiaojian Yin, Qiang Zhang, Ying Huang, Hongbin Pan
BACKGROUND: The utilization of mulberry branch fiber (MF), the largest by-product of the sericulture industry, is an important issue. Supplementation with MF as a dietary fiber for poultry may serve as a useful application. However, little is known about the effects of MF on liver lipid metabolism and egg yolk fatty acid composition of laying hens and their underlying mechanisms. In this study, we performed a multi-omics investigation to explore the variations in liver lipid metabolism, egg yolk fatty acid composition, gut microbiota, and the associations among them induced by dietary MF in laying hens...
April 12, 2024: Microbiome
#11
JOURNAL ARTICLE
Sarahí Vega-Heredia, Ivone Giffard-Mena, Miriam Reverter
Climate change and the associated environmental temperature fluctuations are contributing to increases in the frequency and severity of disease outbreaks in both wild and farmed aquatic species. This has a significant impact on biodiversity and also puts global food production systems, such as aquaculture, at risk. Most infections are the result of complex interactions between multiple pathogens, and understanding these interactions and their co-evolutionary mechanisms is crucial for developing effective diagnosis and control strategies...
April 11, 2024: Diseases of Aquatic Organisms
#12
JOURNAL ARTICLE
Nicole Schmid, David Brandt, Claudia Walasek, Clara Rolland, Johannes Wittmann, Dorian Fischer, Mathias Müsken, Jörn Kalinowski, Kai Thormann
Bacterial viruses (phages) are potent agents of lateral gene transfer and thus are important drivers of evolution. A group of mobile genetic elements, referred to as phage satellites, exploits phages to disseminate their own genetic material. Here, we isolated a novel member of the family Inoviridae, Shewanella phage Dolos, along with an autonomously replicating plasmid, pDolos. Dolos causes a chronic infection in its host Shewanella oneidensis by phage production with only minor effects on the host cell proliferation...
April 10, 2024: Applied and Environmental Microbiology
#13
REVIEW
Uncovering the diversity of pathogenic invaders: insights into protozoa, fungi, and worm infections.
Richa Shukla, Jyoti Soni, Ashish Kumar, Rajesh Pandey
Post COVID-19, there has been renewed interest in understanding the pathogens challenging the human health and evaluate our preparedness towards dealing with health challenges in future. In this endeavour, it is not only the bacteria and the viruses, but a greater community of pathogens. Such pathogenic microorganisms, include protozoa, fungi and worms, which establish a distinct variety of disease-causing agents with the capability to impact the host's well-being as well as the equity of ecosystem. This review summarises the peculiar characteristics and pathogenic mechanisms utilized by these disease-causing organisms...
2024: Frontiers in Microbiology
#14
REVIEW
Exploring the role of the human microbiome in forensic identification: opportunities and challenges.
Lorenzo Franceschetti, Giorgia Lodetti, Alberto Blandino, Alberto Amadasi, Valentina Bugelli
Forensic microbiology is rapidly emerging as a novel tool for human identification. The human microbiome, comprising diverse microbial communities including fungi, bacteria, protozoa, and viruses, is unique to each individual, offering a new dimension to forensic investigations. While traditional identification methods primarily rely on DNA profiling and fingerprint analysis, they face limitations when complete DNA or fingerprints profiles are unattainable or degraded. In this context, the microbial signatures of the human skin microbiome present a promising alternative due to their resilience to environmental stresses and individual-specific composition...
April 10, 2024: International Journal of Legal Medicine
#15
JOURNAL ARTICLE
Zoë A P Williams, Leonie Lang, Sarah Nicolas, Gerard Clarke, John Cryan, David Vauzour, Yvonne M Nolan
Alzheimer's disease is a complex and progressive condition that affects essential neurological functions such as memory and reasoning. In the brain, neuronal loss, synaptic dysfunction, proteinopathy, neurofibrillary tangles, and neuroinflammation are the hallmarks of Alzheimer's disease pathophysiology. In addition, recent evidence has highlighted that microbes, whether commensal or pathogenic, also have the ability to interact with their host and to regulate its immune system, therefore participating in the exchanges that lead to peripheral inflammation and neuropathology...
April 2024: Microbial Biotechnology
#16
COMMENT
Xiangyu Zhang, Shun Li, Mengzhou Xue
A recent study published in mBio by Cao et al. revealed the crucial roles of bacteria in benefitting SARS-CoV-2 mutations (B. Cao, X. Wang, W. Yin, Z. Gao, and B. Xia, mBio e3187-23, 2024, https://doi.org/10.1128/mbio.03187-23). Understanding the underlying mechanisms driving the evolution of SARS-CoV-2 is crucial for predicting the future trajectory of the COVID-19 pandemic and developing preventive and treatment strategies. This study provides important insights into the rapid and complex evolution of viruses facilitated by bacterial-virus interactions...
April 9, 2024: MBio
#17
REVIEW
In-Young Chung, Jihyun Kim, Ara Koh
In the evolving landscape of cancer research, the human microbiome emerges as a pivotal determinant reshaping our understanding of tumorigenesis and therapeutic responses. Advanced sequencing technologies have uncovered a vibrant microbial community not confined to the gut but thriving within tumor tissues. Comprising bacteria, viruses, and fungi, this diverse microbiota displays distinct signatures across various cancers, with most research primarily focusing on bacteria. The correlations between specific microbial taxa within different cancer types underscore their pivotal roles in driving tumorigenesis and influencing therapeutic responses, particularly in chemotherapy and immunotherapy...
April 8, 2024: Journal of Microbiology / the Microbiological Society of Korea
#18
REVIEW
Xiao Yu, Li Cheng, Xin Yi, Bing Li, Xueqin Li, Xiang Liu, Zhihong Liu, Xiaomei Kong
The human gut microbiome plays a critical role in maintaining our health. Fluctuations in the diversity and structure of the gut microbiota have been implicated in the pathogenesis of several metabolic and inflammatory conditions. Dietary patterns, medication, smoking, alcohol consumption, and physical activity can all influence the abundance of different types of microbiota in the gut, which in turn can affect the health of individuals. Intestinal phages are an essential component of the gut microbiome, but most studies predominantly focus on the structure and dynamics of gut bacteria while neglecting the role of phages in shaping the gut microbiome...
2024: Frontiers in Microbiology
#19
JOURNAL ARTICLE
Xu Cao, Lan Huang, Min Tang, Yue Liang, Xinpeng Liu, Huijin Hou, Shufang Liang
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed enormous challenges to global public health. The use of antibiotics has greatly increased during the SARS-CoV-2 epidemic owing to the presence of bacterial co-infection and secondary bacterial infections. The antibiotics daptomycin (DAP) is widely used in the treatment of infectious diseases caused by gram-positive bacteria owing to its highly efficient antibacterial activity. It is pivotal to study the antibiotics usage options for patients of coronavirus infectious disease (COVID-19) with pneumonia those need admission to receive antibiotics treatment for bacterial co-infection in managing COVID-19 disease...
April 5, 2024: Virulence
#20
JOURNAL ARTICLE
Yingjian Wu, Na Gao, Chuqing Sun, Tong Feng, Qingyou Liu, Wei-Hua Chen
BACKGROUND: Ruminants are important livestock animals that have a unique digestive system comprising multiple stomach compartments. Despite significant progress in the study of microbiome in the gastrointestinal tract (GIT) sites of ruminants, we still lack an understanding of the viral community of ruminants. Here, we surveyed its viral ecology using 2333 samples from 10 sites along the GIT of 8 ruminant species. RESULTS: We present the Unified Ruminant Phage Catalogue (URPC), a comprehensive survey of phages in the GITs of ruminants including 64,922 non-redundant phage genomes...
April 4, 2024: Microbiome
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
