keyword
MENU ▼
Read by QxMD icon Read
search

H1N1

keyword
https://www.readbyqxmd.com/read/28212032/chrodrimanins-k-n-and-related-meroterpenoids-from-the-fungus-penicillium-sp-scs-kfd09-isolated-from-a-marine-worm-sipunculus-nudus
#1
Fan-Dong Kong, Qing-Yun Ma, Sheng-Zhuo Huang, Pei Wang, Jun-Feng Wang, Li-Man Zhou, Jing-Zhe Yuan, Hao-Fu Dai, You-Xing Zhao
Six new meroterpenoids, chrodrimanins K-N (1-4), including two uncommon chlorinated ones (1 and 2), and verruculides B2 (5) and B3 (6), as well as seven known ones (7-13), were isolated from the fermentation broth of Penicillium sp. SCS-KFD09 isolated from a marine worm, Sipunculus nudus, from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data, X-ray diffraction analysis, and ECD spectra analysis along with quantum ECD calculations...
February 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28210631/immunogenicity-and-cross-protection-in-mice-afforded-by-pandemic-h1n1-live-attenuated-influenza-vaccine-containing-wild-type-nucleoprotein
#2
Andrey Rekstin, Irina Isakova-Sivak, Galina Petukhova, Daniil Korenkov, Igor Losev, Tatiana Smolonogina, Tatiana Tretiak, Svetlana Donina, Svetlana Shcherbik, Tatiana Bousse, Larisa Rudenko
Since conserved viral proteins of influenza virus, such as nucleoprotein (NP) and matrix 1 protein, are the main targets for virus-specific CD8+ cytotoxic T-lymphocytes (CTLs), we hypothesized that introduction of the NP gene of wild-type virus into the genome of vaccine reassortants could lead to better immunogenicity and afford better protection. This paper describes in vitro and in vivo preclinical studies of two new reassortants of pandemic H1N1 live attenuated influenza vaccine (LAIV) candidates. One had the hemagglutinin (HA) and neuraminidase (NA) genes from A/South Africa/3626/2013 H1N1 wild-type virus on the A/Leningrad/134/17/57 master donor virus backbone (6 : 2 formulation) while the second had the HA, NA, and NP genes of the wild-type virus on the same backbone (5 : 3 formulation)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28209343/a-clinical-trial-of-intradermal-and-intramuscular-seasonal-influenza-vaccination-in-patients-with-atopic-dermatitis
#3
Donald Y M Leung, Brett Jepson, Lisa A Beck, Jon M Hanifin, Lynda C Schneider, Amy S Paller, Katherine Monti, Gloria David, Jennifer Canniff, Margarita Gomez Lorenzo, Adriana Weinberg
BACKGROUND: Antibody responses to the inactivated seasonal influenza vaccine in patients with atopic dermatitis (AD) have not been carefully characterized. OBJECTIVE: The primary objective of this study was to compare antibody responses to intradermal vaccination in participants with moderate/severe AD with those in nonatopic participants. Secondary objectives were to evaluate the effect of route of administration, Staphylococcus aureus skin colonization, and disease severity on vaccine response...
January 31, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28207989/predictors-of-influenza-a-molecular-viral-shedding-in-hutterites-communities
#4
Biao Wang, Margaret L Russell, Kevin Fonseca, David J D Earn, Gregory Horsman, Paul Van Caeseele, Khami Chokani, Mark Vooght, Lorne Babiuk, Stephen D Walter, Mark Loeb
BACKGROUND: Patterns of influenza molecular viral shedding following influenza infection have been well established; predictors of viral shedding however remain uncertain. OBJECTIVES: We sought to determine factors associated with peak molecular viral load, duration of shedding, and viral area under curve (AUC) in children and adult Hutterite colony members with laboratory confirmed influenza. METHODS: A cohort study was conducted in Hutterite colonies in Alberta, Canada...
February 16, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28207986/novel-multiplex-assay-platforms-to-detect-influenza-a-hemagglutinin-subtype-specific-antibody-responses-for-high-throughput-and-in-field-applications
#5
Zhu-Nan Li, Jessica F Trost, Kimberly M Weber, Elizabeth H LeMasters, Sharifa Nasreen, Javan Esfandiari, Angelo H Gunasekera, Megan McCausland, Katharine Sturm-Ramirez, Jens Wrammert, Sean Gregory, Vic Veguilla, James Stevens, Joseph D Miller, Jacqueline M Katz, Min Z Levine
BACKGROUND: Detections of influenza A subtype specific antibody responses are often complicated by the presence of cross-reactive antibodies. We developed two novel multiplex platforms for antibody detection. The multiplexed magnetic fluorescence microsphere immunoassay (MAGPIX) is a high throughput laboratory-based assay. Chembio Dual Path Platform (DPP) is a portable and rapid test that could be used in the field. METHODS: Twelve recombinant globular head domain hemagglutinin (GH HA1) antigens from A(H1N1)pdm09 (pH1N1), A(H2N2), A(H3N2), A(H5N1), A(H7N9), A(H9N2), A(H13N9), B/Victoria lineage, B/Yamagata lineage viruses, and protein A control were used...
February 16, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28207898/distinct-susceptibility-and-applicability-of-mdck-derivatives-for-influenza-virus-research
#6
Shih-Chao Lin, Matthew A Kappes, Mei-Chun Chen, Chi-Chen Lin, Tony T Wang
Madin-Darby Canine Kidney (MDCK) cells are widely utilized as a substrate for influenza virus isolation and propagation due to the high yields of virus. Here we compared the conventional MDCK cell line, MDCK-SIAT1 and MDCK-London for viral production, cell survival, and suitability in testing antivirals using six influenza strains including two H1N1 (pandemic and epidemic strains), three H3N2 and one influenza B strain. Overall our results suggest that MDCK-London cell line is superior for virus culturing and quantification, and hence an ideal platform to evaluate antiviral drug efficacy against multiple strains of influenza...
2017: PloS One
https://www.readbyqxmd.com/read/28207684/update-influenza-activity-united-states-october-2-2016-february-4-2017
#7
Lenee Blanton, Desiree Mustaquim, Noreen Alabi, Krista Kniss, Natalie Kramer, Alicia Budd, Shikha Garg, Charisse N Cummings, Alicia M Fry, Joseph Bresee, Wendy Sessions, Rebecca Garten, Xiyan Xu, Anwar Isa Abd Elal, Larisa Gubareva, John Barnes, David E Wentworth, Erin Burns, Jacqueline Katz, Daniel Jernigan, Lynnette Brammer
This report summarizes U.S. influenza activity* during October 2, 2016-February 4, 2017,(†) and updates the previous summary (1). Influenza activity in the United States began to increase in mid-December, remained elevated through February 4, 2017, and is expected to continue for several more weeks. To date, influenza A (H3N2) viruses have predominated overall, but influenza A (H1N1)pdm09 and influenza B viruses have also been identified.
February 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28206909/a-highly-pathogenic-avian-derived-influenza-virus-h5n1-with-2009-pandemic-h1n1-internal-genes-demonstrates-increased-replication-and-transmission-in-pigs
#8
Eugenio J Abente, Pravina Kitikoon, Kelly M Lager, Phillip C Gauger, Tavis K Anderson, Amy L Vincent
This study investigated the pathogenicity and transmissibility of a reverse-genetics-derived highly pathogenic avian influenza (HPAI) H5N1 lineage influenza A virus that was isolated from a human, A/Iraq/755/06. We also examined surface gene reassortant viruses composed of the haemagglutinin and neuraminidase from A/Iraq/755/06 and the internal genes of a 2009 pandemic H1N1 virus, A/New York/18/2009 (2Iraq/06 : 6NY/09 H5N1), and haemagglutinin and neuraminidase from A/New York/18/2009 with the internal genes of A/Iraq/755/06 (2NY/09 : 6Iraq/06 H1N1)...
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28199524/impact-of-outpatient-neuraminidase-inhibitor-treatment-in-patients-infected-with-influenza-a-h1n1-pdm09-at-high-risk-of-hospitalization-an-individual-participant-data-ipd-meta-analysis
#9
Sudhir Venkatesan, Puja R Myles, Jo Leonardi-Bee, Stella G Muthuri, Malak Al Masri, Nick Andrews, Carlos Bantar, Gal Dubnov-Raz, Patrick Gérardin, Evelyn Sc Koay, Tze Ping Loh, Ziad Memish, Elizabeth Miller, Maria E Oliva, Barbara A Rath, Brunhilde Schweiger, Julian W Tang, Dat Tran, Tjasa Vidmar, Pauline A Waight, Jonathan S Nguyen-Van-Tam
No abstract text is available yet for this article.
February 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28198459/label-free-detection-of-influenza-viruses-using-a-reduced-graphene-oxide-based-electrochemical-immunosensor-integrated-with-a-microfluidic-platform
#10
Renu Singh, Seongkyeol Hong, Jaesung Jang
Reduced graphene oxide (RGO) has recently gained considerable attention for use in electrochemical biosensing applications due to its outstanding conducting properties and large surface area. This report presents a novel microfluidic chip integrated with an RGO-based electrochemical immunosensor for label-free detection of an influenza virus, H1N1. Three microelectrodes were fabricated on a glass substrate using the photolithographic technique, and the working electrode was functionalized using RGO and monoclonal antibodies specific to the virus...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198028/proinflammatory-chemokines-are-major-mediators-of-exuberant-immune-response-associated-with-influenza-a-h1n1-pdm09-virus-infection
#11
Maria Thomas, Reeta Subramaniam Mani, Mariamma Philip, Ranjeeta Adhikary, Sangeeta Joshi, Srigiri S Revadi, Shashidhar Buggi, Anita Desai, Ravi Vasanthapuram
In India, the case fatality ratio of the pandemic A (H1N1) pdm09 influenza was relatively higher when compared to seasonal influenza A infection. Hypercytokinemia or "cytokine storm" has been previously implicated in the pathogenesis of other influenza viruses. The present study was undertaken to compare the cytokine profiles of A (H1N1) pdm09 influenza and seasonal H3 infection in Indian population and to correlate the findings with disease severity. Plasma levels of 18 cytokines/chemokines were measured by flow-cytometry using a bead based assay in patients infected with A (H1N1) pdm09 virus (n = 96) and Influenza A seasonal H3 virus (n = 30) categorised into mild, moderate and severe groups along with healthy controls (n = 36)...
February 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28197799/the-activity-of-influenza-and-influenza-like-viruses-in-individuals-aged-over-14-in-the-2015-2016-influenza-season-in-poland
#12
D Kowalczyk, K Cieślak, K Szymański, L B Brydak
Infections in every epidemic season induced by respiratory viruses, especially by the influenza virus, are the cause of many illnesses and complications which often end in death. The aim of this study was to determine the activity of influenza and influenza-like viruses in individuals aged over of 14 in Poland during the 2015/2016 epidemic season. A total of 5070 specimens taken from patients were analyzed. The presence of the influenza virus was confirmed in 40.2% of cases, among which the subtype A/H1N1/pdm09 (62...
February 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28197322/discovery-of-novel-orally-bioavailable-%C3%AE-amino-acid-azaindole-inhibitors-of-influenza-pb2
#13
Luc J Farmer, Michael P Clark, Michael J Boyd, Emanuele Perola, Steven M Jones, Alice Tsai, Marc D Jacobs, Upul K Bandarage, Mark W Ledeboer, Tiansheng Wang, Hongbo Deng, Brian Ledford, Wenxin Gu, John P Duffy, Randy S Bethiel, Dean Shannon, Randal A Byrn, Joshua R Leeman, Rene Rijnbrand, Hamilton B Bennett, Colleen O'Brien, Christine Memmott, Kwame Nti-Addae, Youssef L Bennani, Paul S Charifson
In our efforts to develop novel small-molecule inhibitors for the treatment of influenza, we utilized molecular modeling and the X-ray crystal structure of the PB2 subunit of the influenza polymerase to optimize a series of acyclic β-amino acid inhibitors, highlighted by compound 4. Compound 4 showed good oral exposure in both rat and mouse. More importantly, it showed strong potency versus multiple influenza-A strains, including pandemic 2009 H1N1 and avian H5N1 strains and showed a strong efficacy profile in a mouse influenza model even when treatment was initiated 48 h after infection...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28196702/structure-activity-relationship-studies-of-1-1-hydroxyalkyl-rupestonic-acid-methyl-esters-against-influenza-viruses
#14
Gen Li, Jiang-Yu Zhao, Chao Niu, Li-Fei Nie, Chang-Zhi Dong, Haji Akber Aisa
A series of 1-(1'-hydroxyalkyl)rupestonic acid methyl esters were synthesized via the condensation of methyl rupestonate with various aldehydes in the presence of LDA. This mixed aldol reaction was highly stereoselective and all the new compounds were elucidated by detailed NMR and MS analyses. The absolute configurations of the newly formed stereocenters were further confirmed by X-ray crystallographic analysis of 3d, the results of which were found to be opposite to the prediction based on Zimmerman-Traxler's and Houk's models...
June 6, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28195559/selection-of-multi-drug-resistant-influenza-a-and-b-viruses-under-zanamivir-pressure-and-their-replication-fitness-in-ferrets
#15
Ding Yuan Oh, Jacqueline Panozzo, Sophie Vitesnik, Rubaiyea Farrukee, David Piedrafita, Jennifer Mosse, Aeron C Hurt
BACKGROUND: Intravenous zanamivir has been used to treat patients with severe influenza. Because the majority of cases (including immunocompromised patients) require the drug for an extended period of treatment, there is a higher risk that the virus will develop resistance. Therefore, knowing the possible amino acid substitutions that may arise in recently circulating influenza strains under prolonged zanamivir exposure and their impact on antiviral susceptibility is important. METHODS: Influenza A(H1N1)pdm09, A(H3N2) and B virus were serially passaged under increasing zanamivir pressure in vitro...
February 14, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28195529/suppressor-of-cytokine-signaling-socs-5-ameliorates-influenza-infection-via-inhibition-of-egfr-signaling
#16
Lukasz Kedzierski, Michelle D Tate, Alan C Hsu, Tatiana B Kolesnik, Edmond M Linossi, Laura Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, Malcolm R Starkey, Nicola L Bird, Simon M Chatfield, Jeffrey J Babon, Nicholas Huntington, Gabrielle Belz, Andrew Webb, Peter Ab Wark, Nicos A Nicola, Jianqing Xu, Katherine Kedzierska, Philip M Hansbro, Sandra E Nicholson
Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) 5 has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss...
February 14, 2017: ELife
https://www.readbyqxmd.com/read/28193653/the-pa-endonuclease-inhibitor-ro-7-protects-mice-from-lethal-challenge-with-influenza-a-or-b-viruses
#17
Jeremy C Jones, Bindumadhav M Marathe, Peter Vogel, Rodolfo Gasser, Isabel Najera, Elena A Govorkova
Current influenza treatment relies on a single class of antiviral drugs, the neuraminidase inhibitors (NAIs), raising concern over the potential emergence of resistant variants and necessitating the development of novel drugs. In recent years, investigational inhibitors targeting the endonuclease activity of the influenza acidic polymerase (PA) protein have yielded encouraging results, although there are only limited data on their in vivo efficacy. Here, we examined the antiviral potential of the PA endonuclease inhibitor RO-7 in prophylactic and therapeutic regimens in BALB/c mice inoculated with influenza A/California/04/2009 (H1N1)pdm09 or B/Brisbane/60/2008 viruses, which represent currently circulating antigenic variants...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28193244/h1n1-influenza-vaccination-in-hiv-infected-women-on-effective-antiretroviral-treatment-did-not-induce-measurable-antigen-driven-proliferation-of-the-hiv-1-proviral-reservoir
#18
Thor A Wagner, Hannah C Huang, Christen E Salyer, Kelly M Richardson, Adriana Weinberg, Sharon Nachman, Lisa M Frenkel
OBJECTIVES: Antigen-induced activation and proliferation of HIV-1-infected cells is hypothesized to be a mechanism of HIV persistence during antiretroviral therapy. The objective of this study was to determine if proliferation of H1N1-specific HIV-infected cells could be detected following H1N1 vaccination. METHODS: This study utilized cryopreserved PBMC from a previously conducted trial of H1N1 vaccination in HIV-infected pregnant women. HIV-1 DNA concentrations and 437 HIV-1 C2V5 env DNA sequences were analyzed from ten pregnant women on effective antiretroviral therapy, before and 21 days after H1N1 influenza vaccination...
February 13, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28192418/defining-the-antibody-cross-reactome-directed-against-the-influenza-virus-surface-glycoproteins
#19
Raffael Nachbagauer, Angela Choi, Ariana Hirsh, Irina Margine, Sayaka Iida, Aldo Barrera, Marcela Ferres, Randy A Albrecht, Adolfo García-Sastre, Nicole M Bouvier, Kimihito Ito, Rafael A Medina, Peter Palese, Florian Krammer
Infection with influenza virus induces antibodies to the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To assess the breadth and magnitude of antibody responses, we sequentially infected mice, guinea pigs and ferrets with divergent H1N1 or H3N2 subtypes of influenza virus. We measured antibody responses by ELISA of an extensive panel of recombinant glycoproteins representing the viral diversity in nature. Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses...
February 13, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28188897/unmasking-survival-biases-in-observational-treatment-studies-of-influenza-patients
#20
Martin Wolkewitz, Martin Schumacher
BACKGROUND: Several observational studies reported that Oseltamivir (Tamiflu) reduced mortality in infected and hospitalized patients. Due to the restriction of observation to hospital stay and time-dependent treatment assignment, such findings were prone to common types of survival bias (length, time-dependent and competing risk bias). METHODS: British hospital data from the FLU-CIN study group were used which included 1391 patients with confirmed pandemic influenza A/H1N1 2009 infection...
February 7, 2017: Journal of Clinical Epidemiology
keyword
keyword
2269
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"