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https://www.readbyqxmd.com/read/29667576/case-of-seasonal-reassortant-a-h1n2-influenza-virus-infection-the-netherlands-march-2018
#1
Adam Meijer, Corien M Swaan, Martin Voerknecht, Edin Jusic, Sharon van den Brink, Lisa A Wijsman, Bettie Cg Voordouw, Gé A Donker, Jacqueline Sleven, Wendelien W Dorigo-Zetsma, Sanela Svraka, Michiel van Boven, Manon R Haverkate, Aura Timen, Jaap T van Dissel, Marion Pg Koopmans, Theo M Bestebroer, Ron Am Fouchier
A seasonal reassortant A(H1N2) influenza virus harbouring genome segments from seasonal influenza viruses A(H1N1)pdm09 (HA and NS) and A(H3N2) (PB2, PB1, PA, NP, NA and M) was identified in March 2018 in a 19-months-old patient with influenza-like illness (ILI) who presented to a general practitioner participating in the routine sentinel surveillance of ILI in the Netherlands. The patient recovered fully. Further epidemiological and virological investigation did not reveal additional cases.
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29666618/reassortant-h5n1-avian-influenza-virus-bearing-pb2-gene-from-a-2009-pandemic-h1n1-exhibits-increased-pathogenicity-in-mice
#2
Xian Lin, Shiman Yu, Kelei Guo, Xin Sun, Haiming Yi, Meilin Jin
Reassortment is a key driving force of the evolution and host adaptation of the influenza virus. A(H1N1)pdm2009 (pdm09), a novel H1N1 influenza viral subtype, caused a pandemic in 2009. The strain was established in pig herds and cocirculated with the highly pathogenic H5N1 avian influenza virus. The coexistence of pdm09 with H5N1 raises concerns that reassortment may cause the development of novel viral strains with unpredictable virulence. Given that the viral polymerase subunit PB2 is a determinant of host range and pathogenicity, and that the substantial amino acid differences in PB2 between pdm09 and H5N1, including positions 590/591 and 271, which are shown to play key roles in enhanced polymerase activity in mammalian host cells, we generated a reassortant virus containing PB2 derived from a pdm09 (A/Liaoning/1/2009, LN/09) to investigate if pdm09-derived PB2 can function in a heterologous avian virus isolate as an adaptive strategy, with H5N1 (A/duck/Hubei/hangmei01/2006, HM/06) as the backbone...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29666412/extensive-t-cell-cross-reactivity-between-diverse-seasonal-influenza-strains-in-the-ferret-model
#3
Adrian J Reber, Nedzad Music, Jin Hyang Kim, Shane Gansebom, Jufu Chen, Ian York
Influenza virus causes widespread, yearly epidemics by accumulating surface protein mutations to escape neutralizing antibodies established from prior exposure. In contrast to antibody epitopes, T cell mediated immunity targets influenza epitopes that are more highly conserved and have potential for cross-protection. The extent of T cell cross-reactivity between a diverse array of contemporary and historical influenza strains was investigated in ferrets challenged with 2009 pandemic H1N1 influenza or the seasonal H3N2 strain, A/Perth/16/2009...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664931/factors-associated-with-influenza-vaccination-failure-and-severe-disease-in-a-french-region-in-2015
#4
Julien Marlet, Catherine Gaudy-Graffin, Daniel Marc, Ronan Boennec, Alain Goudeau
Current influenza vaccination strategy is based on limited analyses of circulating strains and has some drawbacks, as illustrated during the 2014-2015 season with the circulation of A(H3N2) viruses belonging to divergent genetic subgroups. We reasoned that these strains, poorly neutralized in vitro, may have been associated with vaccination failure and more severe diseases. We conducted a study on a continuous series of 249 confirmed influenza infections. Incidence was three fold greater than in the previous three years...
2018: PloS One
https://www.readbyqxmd.com/read/29663903/burden-of-influenza-in-less-than-5-year-old-children-admitted-to-hospital-with-pneumonia-in-developing-and-emerging-countries-a-descriptive-multicenter-study
#5
Cédric Dananché, Valentina Sánchez Picot, Thomas Bénet, Mélina Messaoudi, Monidarin Chou, Jianwei Wang, Jean-William Pape, Shally Awasthi, Ashish Bavdekar, Mala Rakoto-Andrianarivelo, Mariam Sylla, Pagbajabyn Nymadawa, Graciela Russomando, Florence Komurian-Pradel, Hubert Endtz, Gláucia Paranhos-Baccalà, Philippe Vanhems, On Behalf Of The Pneumonia Gabriel Network
This descriptive 4-year study reports the proportion of detection of influenza viruses in less than 5-year-old children hospitalized for pneumonia in eight developing and emerging countries and describes clinical and microbiological characteristics of influenza-related pneumonia cases. Hospitalized children presenting radiologically confirmed pneumonia aged 2-60 months were prospectively enrolled in this observational standardized study. Mean proportion of isolated influenza virus was 9.7% (95% confidence interval: 7...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29662313/inhibition-of-h1n1-influenza-virus-induced-apoptosis-by-functionalized-selenium-nanoparticles-with-amantadine-through-ros-mediated-akt-signaling-pathways
#6
Yinghua Li, Zhengfang Lin, Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu
Introduction: As a therapeutic antiviral agent, the clinical application of amantadine (AM) is limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses and meet the growing demand of clinical diagnosis, the use of biological nanoparticles (NPs) has increased in order to develop novel anti-influenza drugs. The antiviral activity of selenium NPs with low toxicity and excellent activities has attracted increasing attention for biomedical intervention in recent years...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29659149/exploring-the-effect-of-previous-inactivated-influenza-vaccination-on-seasonal-influenza-vaccine-effectiveness-against-medically-attended-influenza-results-of-the-european-i-move-multicentre-test-negative-case-control-study-2011-12-2016-17
#7
Marta Valenciano, E Kissling, Amparo Larrauri, Baltasar Nunes, Daniela Pitigoi, Joan O Donnell, Annicka Reuss, Judit Krisztina Horváth, Iwona Paradowska-Stankiewicz, Caterina Rizzo, Alessandra Falchi, Isabel Daviaud, Mia Brytting, Adam Meijer, Bernard Kaic, Alin Gherasim, Ausenda Machado, Alina Ivanciuc, Lisa Domegan, Brunhilde Schweiger, Annamária Ferenczi, Monika Korczyńska, Antonino Bella, Ana-Maria Vilcu, Anne Mosnier, Katherina Zakikhany, Sanja Kurečić Filipovićović, Kari Johansen, Alain Moren, Marit de Lange
BACKGROUND: Results of previous influenza vaccination effects on current season influenza vaccine effectiveness (VE) are inconsistent. OBJECTIVES: To explore previous influenza vaccination effects on current season VE among population targeted for vaccination. METHODS: We used 2011/12 to 2016/17 I-MOVE primary care multicentre test-negative data. For each season we compared current season adjusted VE (aVE) between individuals vaccinated and unvaccinated in previous season...
April 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29655370/descriptive-study-of-severe-hospitalized-cases-of-laboratory-confirmed-influenza-during-five-epidemic-seasons-2010-2015
#8
Núria Torner, Ana Martínez, Luca Basile, MMar Mosquera, Andrés Antón, Cristina Rius, M Rosa Sala, Sofia Minguell, Elsa Plasencia, Mónica Carol, Pere Godoy, Núria Follia, Irene Barrabeig, M Angeles Marcos, Tomàs Pumarola, Mireia Jané
OBJECTIVE: The Plan of Information on Acute Respiratory Infections in Catalonia (PIDIRAC) included the surveillance of severe hospitalized cases of laboratory-confirmed influenza (SHCLCI) in 2009. The objective of this study was to determine the clinical, epidemiological and virological features of SHCLCI recorded in 12 sentinel hospitals during five influenza seasons. RESULTS: From a sample of SHCLCI recorded during the 5 influenza epidemics seasons from 2010-2011 to 2014-2015, Cases were confirmed by PCR and/or viral isolation in cell cultures from respiratory samples...
April 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29653203/approximate-bayesian-algorithm-to-estimate-the-basic-reproduction-number-in-an-influenza-pandemic-using-arrival-times-of-imported-cases
#9
Ka Chun Chong, Benny Chung Ying Zee, Maggie Haitian Wang
BACKGROUND: In an influenza pandemic, arrival times of cases are a proxy of the epidemic size and disease transmissibility. Because of intense surveillance of travelers from infected countries, detection is more rapid and complete than on local surveillance. Travel information can provide a more reliable estimation of transmission parameters. METHOD: We developed an Approximate Bayesian Computation algorithm to estimate the basic reproduction number (R0 ) in addition to the reporting rate and unobserved epidemic start time, utilizing travel, and routine surveillance data in an influenza pandemic...
April 10, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29652789/terpenoids-from-the-soft-coral-sinularia-sp-collected-in-yongxing-island
#10
Guo-Fei Qin, Xu-Li Tang, Yan-Ting Sun, Xiang-Chao Luo, Jing Zhang, Leen van Ofwegen, Ping-Jyun Sung, Ping-Lin Li, Guo-Qiang Li
Three new sesquiterpenoids (sinuketal ( 1 ), sinulins A and B ( 2 and 3 )) and two new cembranoids (sinulins C and D ( 4 and 5 )), as well as eight known sesquiterpenoids ( 6–13 ) and eight known cembranoids ( 14–21 ), were isolated from the Xisha soft coral Sinularia sp. Their structures were elucidated by extensive spectroscopic analysis. Compound 1 possesses an unprecedented isopropyl-branched bicyclo [6.3.0] undecane carbon skeleton with unique endoperoxide moiety, and a plausible biosynthetic pathway of it was postulated...
April 13, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29650021/overexpression-of-a-type-iii-pks-gene-affording-novel-violapyrones-with-enhanced-anti-influenza-a-virus-activity
#11
Lukuan Hou, Huiming Huang, Huayue Li, Shuyao Wang, Jianhua Ju, Wenli Li
BACKGROUND: Type III polyketide synthases (PKSs) are simple homodimer ketosynthases that distribute across plants, fungi, and bacteria, catalyzing formation of pyrone- and resorcinol-types aromatic polyketides with various bioactivities. The broad substrate promiscuity displayed by type III PKSs makes them wonderful candidates for expanding chemical diversity of polyketides. RESULTS: Violapyrone B (VLP B, 10), an α-pyrone compound produced by deepsea-derived Streptomyces somaliensis SCSIO ZH66, is encoded by a type III PKS VioA...
April 12, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29642453/glycosylation-of-hemagglutinin-and-neuraminidase-of-influenza-a-virus-as-signature-for-ecological-spillover-and-adaptation-among-influenza-reservoirs
#12
Paul Kim, Yo Han Jang, Soon Bin Kwon, Chung Min Lee, Gyoonhee Han, Baik Lin Seong
Glycosylation of the hemagglutinin (HA) and neuraminidase (NA) of the influenza provides crucial means for immune evasion and viral fitness in a host population. However, the time-dependent dynamics of each glycosylation sites have not been addressed. We monitored the potential N-linked glycosylation (NLG) sites of over 10,000 HA and NA of H1N1 subtype isolated from human, avian, and swine species over the past century. The results show a shift in glycosylation sites as a hallmark of 1918 and 2009 pandemics, and also for the 1976 "abortive pandemic"...
April 7, 2018: Viruses
https://www.readbyqxmd.com/read/29629834/second-generation-nitazoxanide-derivatives-thiazolides-are-effective-inhibitors-of-the-influenza-a-virus
#13
Andrew V Stachulski, M Gabriella Santoro, Sara Piacentini, Giuseppe Belardo, Simone La Frazia, Chandrakala Pidathala, Eleanor C Row, Neil G Berry, Mazhar Iqbal, Sarah A Allman, J Edward Semple, Brian M Eklov, Paul M O'Neill, Jean-Francois Rossignol
AIM: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against acute uncomplicated influenza. RESULTS: We report the activity of seventeen thiazolide analogs against A/PuertoRico/8/1934(H1N1), a laboratory-adapted strain of the H1N1 subtype of IAV, in a cell culture-based assay...
April 9, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29628293/social-media-and-outbreaks-of-emerging-infectious-diseases-a-systematic-review-of-literature
#14
REVIEW
Lu Tang, Bijie Bie, Sung-Eun Park, Degui Zhi
BACKGROUND: The public often turn to social media for information during emerging infectious diseases (EIDs) outbreaks. This study identified the major approaches and assessed the rigors in published research articles on EIDs and social media. METHODS: We searched 5 databases for published journal articles on EIDs and social media. We then evaluated these articles in terms of EIDs studied, social media examined, theoretical frameworks, methodologic approaches, and research findings...
April 5, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29627234/nasal-vaccination-with-r4m2e-hsp70c-antigen-encapsulated-into-n-trimethyl-chitosan-tmc-nanoparticulate-systems-preparation-and-immunogenicity-in-a-mouse-model
#15
Mehran Dabaghian, Ali Mohammad Latifi, Majid Tebianian, Hamid NajmiNejad, Seyyed Mahmoud Ebrahimi
In this study, the potential of N-trimethyl chitosan (TMC) nanoparticles as a carrier system for the nasal delivery of the r4M2e.HSP70c, as an M2e-based universal recombinant influenza virus vaccine candidate, was investigated in mice. The anti-M2e specific cellular and humoral immune responses were assessed and the protective efficacy against a 90% lethal dose (LD90) of influenza A/PR/8/34 (H1N1) in a mice model was evaluated. Our results showed that the intranasal immunization of mice with r4M2e.HSP70c+TMC rather than the control groups, r4M2e+TMC, r4M2e and PBS (Phosphate buffer saline), significantly elevated both longevity and serum level of the total M2e-specific IgG antibody with a significant shift in the IgG2a/IgG1 ratio toward IgG2a, induced a Th1 skewed humoral and cellular immune responses, increased IFN-γ, IgG, and IgA in the bronchoalveolar lavage fluid (BALF), and promoted the proliferation of peripheral blood lymphocytes with lower morbidity and mortality rate against viral challenge...
April 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29625766/a-follow-up-comparative-safety-analysis-of-pandemic-h1n1-vaccination-during-pregnancy-and-risk-of-infant-birth-defects-among-u-s-military-mothers
#16
Ava Marie S Conlin, Anna T Bukowinski, Jordan A Levine, Zeina G Khodr, Navjot Kaur, Susan C Farrish, Carter J Sevick
OBJECTIVE: To update a previous assessment of birth defects among infants born to active duty U.S. military mothers who received the 2009-2010 pandemic H1N1 vaccine, in comparison to the 2008-2009 seasonal influenza vaccine, during pregnancy. Here, we updated the previous comparative analyses with a more refined definition for birth defects using an additional year of follow-up data from both inpatient and outpatient medical encounters. METHODS: The study population included 15,510 live born infants born to active duty mothers vaccinated during pregnancy with either the 2009-2010 pandemic H1N1 vaccine (n = 9033) or the 2008-2009 seasonal influenza vaccine (n = 6477)...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29625056/influenza-infection-in-humans-induces-broadly-cross-reactive-and-protective-neuraminidase-reactive-antibodies
#17
Yao-Qing Chen, Teddy John Wohlbold, Nai-Ying Zheng, Min Huang, Yunping Huang, Karlynn E Neu, Jiwon Lee, Hongquan Wan, Karla Thatcher Rojas, Ericka Kirkpatrick, Carole Henry, Anna-Karin E Palm, Christopher T Stamper, Linda Yu-Ling Lan, David J Topham, John Treanor, Jens Wrammert, Rafi Ahmed, Maryna C Eichelberger, George Georgiou, Florian Krammer, Patrick C Wilson
Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly display key NA epitopes and rarely induce NA-reactive B cells. Conversely, influenza virus infection induces NA-reactive B cells at a frequency that approaches (H1N1) or exceeds (H3N2) that of HA-reactive B cells. NA-reactive antibodies display broad binding activity spanning the entire history of influenza A virus circulation in humans, including the original pandemic strains of both H1N1 and H3N2 subtypes...
April 5, 2018: Cell
https://www.readbyqxmd.com/read/29624873/regional-patterns-of-genetic-diversity-in-swine-influenza-a-viruses-in-the-united-states-from-2010-to-2016
#18
Rasna R Walia, Tavis K Anderson, Amy L Vincent
BACKGROUND: Regular spatial and temporal analyses of the genetic diversity and evolutionary patterns of influenza A virus (IAV) in swine informs control efforts and improves animal health. Initiated in 2009, the USDA passively surveils IAV in U.S. swine, with a focus on subtyping clinical respiratory submissions, sequencing at minimum the hemagglutinin (HA) and neuraminidase (NA) genes, and sharing these data publicly. OBJECTIVES: In this study, our goal was to quantify and describe regional and national patterns in the genetic diversity and evolution of IAV in U...
April 6, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29624498/mutations-conferring-increased-sensitivity-to-tripartite-motif-22-restriction-accumulated-progressively-in-the-nucleoprotein-of-seasonal-influenza-a-h1n1-viruses-between-1918-and-2009
#19
Isabel Pagani, Andrea Di Pietro, Alexandra Oteiza, Michela Ghitti, Nadir Mechti, Nadia Naffakh, Elisa Vicenzi
Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations. We have previously reported that the interferon (IFN)-inducible tripartite motif 22 (TRIM22) protein restricts the replication of seasonal IAVs by direct interaction with the viral nucleoprotein (NP), leading to its polyubiquitination and proteasomal degradation. Here we show that, in contrast to seasonal H1N1 IAVs, the 2009 pandemic H1N1 strain as well as H1N1 strains from the 1930s are resistant to TRIM22 restriction...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29623897/hesperidin-attenuates-influenza-a-virus-h1n1-induced-lung-injury-in-rats-through-its-anti-inflammatory-effect
#20
Zhen Ding, Gengyun Sun, Zhongming Zhu
BACKGROUND: Influenza A viruses (IAV) can cause pandemics and are big threats to human health. Inflammation is the main pathological process in the lungs after IAV infection. We aimed at investigating whether hesperidin, a well-known anti-inflammatory material, could be effective in improving IAV-induced lung injury. METHODS: We generated a rat model using H1N1 virus infection, and intraperitoneally injected with different doses of hesperidin for 5 days. Pulmonary function was analyzed...
April 6, 2018: Antiviral Therapy
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