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https://www.readbyqxmd.com/read/29351706/micrornas-and-target-genes-in-pituitary-adenomas
#1
Yajuan Feng, Zhi-Gang Mao, Xin Wang, Qiu Du, Mengyao Jian, Dimin Zhu, Zheng Xiao, Hai-Jun Wang, Yong-Hong Zhu
Pituitary adenomas account for the top three primary intracranial tumors in terms of total incidence rates. The clinical symptoms presented by the disease are often characterized by a series of systemic endocrine disorders, severe occupational lesions, and even some malignant features, and therefore early diagnosis and predicting recurrence would be instructive for clinical treatment of pituitary adenomas. An increasing number of specific microRNA (miRNA) expression signatures have been identified in pituitary, and miRNAs are related with the pituitary tumorigenesis, dysfunction, neurodegeneration, and metastatic non-functioning pituitary carcinoma...
January 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29351286/socio-economic-determinants-of-physical-activity-across-the-life-course-a-determinants-of-diet-and-physical-activity-dedipac-umbrella-literature-review
#2
Grainne O'Donoghue, Aileen Kennedy, Anna Puggina, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Donatella Ciarapica, Marco Colotto, Giancarlo Condello, Tara Coppinger, Cristina Cortis, Sara D'Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Fiona Ling, Agnes Luzak, Giorgio Napolitano, Julie-Anne Nazare, Camille Perchoux, Caterina Pesce, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Chantal Simon, Rhoda Sohun, Astrid Steinbrecher, Wolfgang Schlicht, Ciaran MacDonncha, Laura Capranica, Stefania Boccia
BACKGROUND: To date, the scientific literature on socioeconomic correlates and determinants of physical activity behaviours has been dispersed throughout a number of systematic reviews, often focusing on one factor (e.g. education or parental income) in one specific age group (e.g. pre-school children or adults). The aim of this umbrella review is to provide a comprehensive and systematic overview of the scientific literature from previously conducted research by summarising and synthesising the importance and strength of the evidence related to socioeconomic correlates and determinants of PA behaviours across the life course...
2018: PloS One
https://www.readbyqxmd.com/read/29351218/transparent-fingerprint-sensor-system-for-large-flat-panel-display
#3
Wonkuk Seo, Jae-Eun Pi, Sung Haeung Cho, Seung-Youl Kang, Seong-Deok Ahn, Chi-Sun Hwang, Ho-Sik Jeon, Jong-Uk Kim, Myunghee Lee
In this paper, we introduce a transparent fingerprint sensing system using a thin film transistor (TFT) sensor panel, based on a self-capacitive sensing scheme. An armorphousindium gallium zinc oxide (a-IGZO) TFT sensor array and associated custom Read-Out IC (ROIC) are implemented for the system. The sensor panel has a 200 × 200 pixel array and each pixel size is as small as 50 μm × 50 μm. The ROIC uses only eight analog front-end (AFE) amplifier stages along with a successive approximation analog-to-digital converter (SAR ADC)...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29351091/circadian-rhythms-disturbances-in-alzheimer-disease-current-concepts-diagnosis-and-management
#4
Ángela Milán-Tomás, Colin M Shapiro
The purpose of this review is to provide an overview of the research regarding circadian rhythms in Alzheimer disease (AD). Furthermore, this paper explores the role of melatonin in the pathogenesis of AD and the limitation of trials addressing circadian rhythms disturbances in the AD population. A literature search using Medline with PubMed and Embase was carried out identifying papers focusing on circadian rhythms in AD. Sleep disorders and especially circadian rhythm disturbances are very common in the elderly population but definitely more pronounced in patients with AD...
January 18, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29350652/complications-associated-with-brachioplasty-a-literature-review
#5
Andrea Sisti, Roberto Cuomo, Luca Milonia, Juri Tassinari, Antonio Castagna, Antonio Castagna, Cesare Brandi, Luca Grimaldi, Carlo D'Aniello, Giuseppe Nisi
BACKGROUND: Paralleling the growth of bariatric surgery, the demand for post-bariatric body-contouring surgery is increasing. Weight loss is the main cause, although not the only one, that drives patients to arm lift surgery. Several surgical techniques have been proposed over the years. Our aim was to consider the complications and outcomes according to the performed technique, through a wide review of the literature. METHODS: A search on PubMed/Medline was performed using "brachioplasty", "upper arm lifting", and "techniques" as key words...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350645/developments-in-the-management-of-bone-metastases-with-interventional-radiology
#6
Francesco Arrigoni, Federico Bruno, Luigi Zugaro, Raffaele Natella, Salvatore Cappabianca, Umberto Russo, Vito Roberto Papapietro, Alessandra Splendiani, Ernesto Di Cesare, Carlo Masciocchi, Antonio Barile
Interventional radiology has known an exponential growth in the last years. Technological advances of the last decades, have made it possible to use new treatments on a larger scale, with safe and effective results. They could be considered as palliative treatments for painful lesions but also curative procedures, as single treatment or specially in combination with other techniques (surgery, radiation and oncology therapies, etc.).The main diffuse techniques are those of thermal ablation that destroy the target lesion through the heat; however there are also endovascular therapies that destroy the target tissue thanks to devascularization...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350593/the-natural-history-of-complete-spinal-cord-injury-a-pooled-analysis-of-1162-patients-and-a-meta-analysis-of-modern-data
#7
Najib E El Tecle, Nader S Dahdaleh, Mohamad Bydon, Wilson Z Ray, James C Torner, Patrick W Hitchon
OBJECTIVE The natural history of complete spinal cord injury (SCI) is poorly studied. The classically quoted rate of improvement or conversion for patients with American Spinal Injury Association (ASIA) grade A (ASIA A) injuries is 15%-20%; however, data supporting this rate are very limited. In this paper, the authors conducted a meta-analysis of modern data reporting on ASIA A patients and evaluated factors affecting the natural history of the disease. METHODS The authors conducted a systematic literature review of all randomized clinical trials (RCTs) and observational studies of patients with traumatic SCI...
January 19, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29350548/use-of-helical-tomotherapy-in-locally-advanced-and-or-metastatic-breast-cancer-for-locoregional-treatment
#8
Laura Thery, Alexandre Arsene-Henry, Susan Carroll, Dominique Peurien, Louis Bazire, Magalie Robilliard, Alain Fourquet, Youlia M Kirova
PURPOSE: Helical tomotherapy (HT) is a new promising tool whose use remains to be studied. This work assesses its impact for local irradiation in terms of side effects, as well as tumour control in locally advanced (LABC) and metastatic breast cancer (MBC). METHODS: We retrospectively reviewed data of 66 patients with LABC and MBC. Patients received standard fractionated radiotherapy by HT, with or without concurrent systemic treatment. RESULTS: The median age was 60 years (28-77)...
January 19, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29350384/the-importance-of-psychosocial-factors-in-management-of-pulmonary-arterial-hypertension-patients
#9
Maria A Sobczak-Kaleta, Adam Torbicki, Jarosław D Kasprzak
Pulmonary arterial hypertension (PAH) is significantly reshaping personal and professional lives of patients due to its chronic nature, varying clinical profile and uncertain perspectives of treatment. PAH is at this time an incurable disease, which requires to consider not only strictly medical dimension, but also the psychosocial aspects of care. This paper discusses therefore the psychological problems most commonly reported by PAH patients. It reviews the instruments used to assess them. We describe the relationships between the quality of life and depressive symptoms and the physical activity of the PAH patients, which have deep treatment-related consequences...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350378/eq-5d-studies-in-cardiovascular-diseases-in-eight-central-and-eastern-european-countries-a-systematic-review-of-the-literature
#10
Paulina Batóg, Fanni Rencz, Márta Péntek, László Gulácsi, Krzysztof J Filipiak, Valentina Prevolnik Rupel, Judit Simon, Valentin Brodszky, Petra Baji, Jakub Závada, Guenka Petrova, Alexandru Rotar, Dominik Golicki
BACKGROUND: The measurement of health-related quality of life (HRQOL) by validated generic instruments, such as EQ-5D, becomes an increasingly important tool for the assessment of health care in a wide range of different diagnoses. AIM: To systematically review EQ-5D literature generated in cardiovascular diseases in eight selected Central and Eastern Europe (CEE) countries. METHODS: A structured literature search was conducted in MEDLINE, EMBASE, Web of Science, CINAHL, PsycINFO, the Cochrane Library and the EuroQol website up to November 2016...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350352/the-problem-is-not-professional-publishing-but-the-publish-or-perish-culture
#11
Gonzalo Génova, José Luis de la Vara
The publication of scientific papers has become increasingly problematic in the last decades. Even if we agree that a renewed model is needed for peer-reviewed scientific publication, we think the problem does not essentially lie in professional publishing-with economic incentives-but in the publish-or-perish culture that dominates the lives of researchers and academics.
January 19, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29350315/revisiting-embryo-assisted-hatching-approaches-a-systematic-review-of-the-current-protocols
#12
REVIEW
Alessandra Alteri, Paola Viganò, Ahmad Abu Maizar, Luca Jovine, Elisa Giacomini, Patrizia Rubino
Zona pellucida (ZP) manipulation, termed "assisted hatching" (AH), has been introduced in order to favor embryo hatching and ultimately improve assisted reproductive technology success but with poor proofs of safety and biological plausibility. We herein provide a systematic review of clinical outcomes following the application of different methods of ZP manipulation on fresh or frozen/thawed embryos at different developmental stages in different groups of patients. Out of the 69 papers that compared the clinical outcomes deriving from hatched versus non-hatched embryos, only 11 considered blastocysts while the rest referred to cleavage stage embryos...
January 19, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29350267/modern-work-up-and-extended-resection-in-perihilar-cholangiocarcinoma-the-amc-experience
#13
REVIEW
F Rassam, E Roos, K P van Lienden, J E van Hooft, H J Klümpen, G van Tienhoven, R J Bennink, M R Engelbrecht, A Schoorlemmer, U H W Beuers, J Verheij, M G Besselink, O R Busch, T M van Gulik
AIM: Perihilar cholangiocarcinoma (PHC) is a challenging disease and requires aggressive surgical treatment in order to achieve curation. The assessment and work-up of patients with presumed PHC is multidisciplinary, complex and requires extensive experience. The aim of this paper is to review current aspects of diagnosis, preoperative work-up and extended resection in patients with PHC from the perspective of our own institutional experience with this complex tumor. METHODS: We provided a review of applied modalities in the diagnosis and work-up of PHC according to current literature...
January 19, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29350073/in-their-own-words-a-synthesis-of-the-qualitative-research-on-the-experiences-of-adults-seeking-asylum-a-systematic-review-of-qualitative-findings-in-forced-migration
#14
Thomas Hoare, Andrew Vidgen, Neil Roberts
Quantitative research indicates that some forced migrants have mental health needs. Asylum seekers are a group of forced migrants applying for asylum status in a host country, and are often subject to rights restrictions and threat of deportation, though little is known about subjective experiences of the asylum journey and process of claiming asylum. The current paper therefore describes a systematic review of the qualitative literature, examining asylum seekers experiences of asylum journey, from country of origin, to arrival and adaptation to host countries...
December 2017: Medicine, Conflict, and Survival
https://www.readbyqxmd.com/read/29349895/men-s-views-and-experiences-of-infant-feeding-a-qualitative-systematic-review
#15
Sarah Earle, Robin Hadley
Although the advantages of breastfeeding are well documented, rates for breastfeeding often fall short of international and national targets. Increasing attention has been paid to the role of men in infant feeding, but a lot of the research about men has been elicited from women, rather than from men themselves. To explore these issues further, a systematic review of the qualitative research on infant feeding was carried out, focusing specifically on men's own views and experiences. Evidence was identified by searching electronic databases (CINAL, Cochrane, PubMed, and Scopus), manually searching citations, and by searching the grey literature...
January 19, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29349892/-can-the-patient-speak-postcolonialism-and-patient-involvement-in-undergraduate-and-postgraduate-medical-education
#16
Malika Sharma
CONTEXT: Patients are increasingly being engaged in providing feedback and consultation to health care institutions, and in the training of health care professionals. Such involvement has the potential to disrupt traditional doctor-patient power dynamics in significant ways that have not been theorised in the medical literature. Critical theories can help us understand how power flows when patients are engaged in the training of medical students. METHODS: This paper applies postcolonial theory to the involvement of patients in the development and delivery of medical education...
January 19, 2018: Medical Education
https://www.readbyqxmd.com/read/29349700/adrenergic-and-metabolic-effects-of-electrical-weapons-review-and-meta-analysis-of-human-data
#17
REVIEW
S N Kunz, H G Calkins, J Adamec, M W Kroll
INTRODUCTION: Electronic control with the CEW (conducted electrical weapon) has gained widespread acceptance as the preferred force option due to its significant injury reduction. However, a CEW application does stress the human body. In the case of the CEW, the human body response is similar to the challenge of physical exercise combined with emotional stress over a very short time interval. There has been concern whether the tension of the skeletal-muscle system together with the emotional stress of being exposed to the effects of a CEW, can lead to severe metabolic dysfunction...
January 19, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29349479/resilience-and-protective-factors-among-people-with-a-history-of-child-maltreatment-a-systematic-review
#18
REVIEW
Xiangfei Meng, Marie-Josee Fleury, Yu-Tao Xiang, Muzi Li, Carl D'Arcy
PURPOSE: To provide an overview of resilience and protective factors associated with a better life following child maltreatment exposure, to compare protective factors across specific subtypes of maltreatment, and to explore existing issues in the current state of the literature. METHODS: Electronic databases and grey literature up to October 2017 were systematically searched for English language with observational study designs for the research on resilience and childhood maltreatment...
January 18, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29349043/vermicomposting-and-anaerobic-digestion-viable-alternative-options-for-terrestrial-weed-management-a-review
#19
REVIEW
Biswanath Saha, Chaichi Devi, Meena Khwairakpam, Ajay S Kalamdhad
The management of terrestrial weed is of great concern for the scientific community as these weeds cause adverse effect in different ecosystems like forest, agriculture and urban. The widespread of these weeds by their adaptive capability and morphological advancement is difficult to control. Parthenium hysterophorous, Lantana camara, Saccharum spontaneum, Ageratum conyzoides are the weeds that spread all over the world. There are various management practices employed for the control of this weeds. But all of these practices have some drawbacks those are neither environment friendly nor economical...
March 2018: Biotechnology Reports
https://www.readbyqxmd.com/read/29348731/problems-with-precaution-the-transfusion-medicine-experience
#20
Kumanan Wilson, Katherine M Atkinson, Dean A Fergusson, Adalsteinn Brown, Alan Forster, Malia S Q Murphy, Alan T Tinmouth, Jennifer Keelan
The precautionary principle is a dominant paradigm governing risk-based decision-making. Today, there are increasing pressures to re-examine aggressive precautionary approaches, and to assess how the principle should be applied in the modern system. In this paper, we examined three key applications of precautionary approaches in the field of transfusion medicine to provide insight into the risks and benefits of these approaches. The three case studies examined were the donor deferral policies to safeguard against transfusion transmission of human immunodeficiency virus, variant Creutzfeldt-Jacob disease, and, lastly, xenotropic murine leukemia virus-related virus...
2018: Journal of Risk Research
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