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https://www.readbyqxmd.com/read/28535615/mesenchimal-stem-cells-a-possible-role-in-the-pathogenesis-and-treatment-of-spondyloarthritis
#1
F M Perrotta, G Guerra, A De Socio, S Scriffignano, E Lubrano
Spondyloarthritis (SpAs) are a group of chronic inflammatory diseases that affect joints and enthesis with a possible involvement of other districts such as skin, eye and bowel. In SpAs, the inflammatory process could lead to both erosive damage (as in peripheral joint involvement of psoriatic arthritis), or bone formation (as in ankylosing spondylitis) with a reduction in function and quality of life. Recently, Mesenchimal stem cells (MSCs) transplant was used in different diseases, including autoimmune and inflammatory diseases, with the aim of repairing tissue damage, exploiting their regenerative capacity...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28535601/risk-of-post-fire-metal-mobilization-into-surface-water-resources-a-review
#2
REVIEW
Joji Abraham, Kim Dowling, Singarayer Florentine
One of the significant economic benefits to communities around the world of having pristine forest catchments is the supply of substantial quantities of high quality potable water. This supports a saving of around US$ 4.1 trillion per year globally by limiting the cost of expensive drinking water treatments and provision of unnecessary infrastructure. Even low levels of contaminants specifically organics and metals in catchments when in a mobile state can reduce these economic benefits by seriously affecting the water quality...
May 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28535583/molecular-testing-of-brain-tumor
#3
REVIEW
Sung-Hye Park, Jaekyung Won, Seong-Ik Kim, Yujin Lee, Chul-Kee Park, Seung-Ki Kim, Seung-Hong Choi
The World Health Organization (WHO) classification of central nervous system (CNS) tumors was revised in 2016 with a basis on the integrated diagnosis of molecular genetics. We herein provide the guidelines for using molecular genetic tests in routine pathological practice for an accurate diagnosis and appropriate management. While astrocytomas and IDH-mutant (secondary) glioblastomas are characterized by the mutational status of IDH, TP53 , and ATRX , oligodendrogliomas have a 1p/19q codeletion and mutations in IDH, CIC , FUBP1 , and the promoter region of telomerase reverse transcriptase ( TERTp )...
May 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28535523/mycophenolate-mofetil-a-possible-alternative-treatment-for-iga-nephropathy
#4
Olga Baraldi, Giorgia Comai, Vania Cuna, Maria Cappuccilli, Carla Serra, Claudio Ronco, Gaetano La Manna
IgA nephropathy (IgAN) is the most common primary glomerulonephritis in developed countries and a leading cause of chronic kidney disease. IgAN is a mesangial proliferative glomerulonephritis characterized by diffuse mesangial deposition of IgA, often accompanied by the deposition of IgG and the C3 component of complement in a similar distribution. This condition is in most cases oligosymptomatic, often discovered coincidentally. Currently, there is no specific treatment available for IgAN and the use of immunosuppression therapy is debated...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28535515/extracorporeal-treatments-in-patients-with-acute-kidney-injury-and-sepsis
#5
Marita Marengo, Sergio Dellepiane, Vincenzo Cantaluppi
Acute kidney injury (AKI) is one of the most common sepsis complications, and AKI development increases the risk of sepsis episodes by affecting host immune competence. The concomitance of these 2 clinical syndromes is associated with an extremely poor prognosis with mortality rates ranging from 50 to 70%. These unacceptable outcomes reflect the poor knowledge of the underlying pathogenic mechanisms and the lack of appropriate diagnostic and therapeutic methodologies as well as of appropriate experimental models...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28535398/nurses-occupational-physical-activity-levels-a-systematic-review
#6
REVIEW
Stephanie E Chappel, Simone J J M Verswijveren, Brad Aisbett, Julie Considine, Nicola D Ridgers
BACKGROUND: Nurses' physical performance at work has implications both for nurses' occupational health and patient care. Although nurses are the largest healthcare workforce, are present 24-hours a day, and engage in many physically demanding tasks, nurses' occupational physical activity levels are poorly understood. OBJECTIVES: The aim of this systematic review was to examine nurses' occupational physical activity levels, and explore how nurses accumulate their physical activity during a shift...
May 10, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28535245/invited-commentary-the-continuing-need-for-the-sufficient-cause-model-today
#7
Tyler J VanderWeele
In this commentary, I review the insights that have been gained using Rothman's sufficient cause model (Am J Epidemiol. 1976;104(6):587-592). Discussion pertains to the relations of the model to similar conceptualizations in other fields of study, the advances and extensions that have been made to the model since the paper's publication, and its relation to questions of actual causation, along with questions concerning the use of the model in the future of epidemiology.
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535206/clinical-exome-sequencing-reports-current-informatics-practice-and-future-opportunities
#8
Rajeswari Swaminathan, Yungui Huang, Caroline Astbury, Sara Fitzgerald-Butt, Katherine Miller, Justin Cole, Christopher Bartlett, Simon Lin
The increased adoption of clinical whole exome sequencing (WES) has improved the diagnostic yield for patients with complex genetic conditions. However, the informatics practice for handling information contained in whole exome reports is still in its infancy, as evidenced by the lack of a common vocabulary within clinical sequencing reports generated across genetic laboratories. Genetic testing results are mostly transmitted using portable document format, which can make secondary analysis and data extraction challenging...
May 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28535048/control-of-maillard-reactions-in-foods-strategies-and-chemical-mechanisms
#9
Marianne N Lund, Colin Ray
Maillard reactions lead to changes in food color, organoleptic properties, protein functionality, and protein digestibility. Numerous different strategies for controlling Maillard reactions in foods have been attempted during the last decades. In this paper, recent advances in strategies for controlling the Maillard reaction and subsequent downstream reaction products in food systems are critically reviewed. The underlying mechanisms at play are presented, strengths and weaknesses of each strategy are discussed, and reasonable reaction mechanisms are proposed to reinforce the evaluations...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28534820/antioxidant-properties-of-probiotic-bacteria
#10
REVIEW
Yang Wang, Yanping Wu, Yuanyuan Wang, Han Xu, Xiaoqiang Mei, Dongyou Yu, Yibing Wang, Weifen Li
Oxidative stress defines a condition in which the prooxidant-antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells' viability. Probiotics have been known for many beneficial health effects, and the consumption of probiotics alone or in food shows that strain-specific probiotics can present antioxidant activity and reduce damages caused by oxidation. However, the oxidation-resistant ability of probiotics, especially the underling mechanisms, is not properly understood...
May 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28534710/systematic-review-radiological-and-histological-evidence-of-cochlear-implant-insertion-trauma-in-adult-patients
#11
Emma Hoskison, Scott Mitchell, Chris Coulson
INTRODUCTION: Cochlear implantation (CI) has developed from its origins in the 1980s. Initially, CI was for profound bilateral hearing impairment. However, candidacy for CI have become more widespread in recent years with unilateral implantation and an emphasis on hearing preservation. Evidence supports full electrode insertion in an atraumatic fashion into the scala tympani (ST) provides optimal hearing outcomes. The main aim of this systematic review was to elucidate the degree of trauma associated with CI insertion...
May 23, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28534454/opportunities-and-challenges-in-metabarcoding-approaches-for-helminth-community-identification-in-wild-mammals
#12
Tuomas Aivelo, Alan Medlar
Despite metabarcoding being widely used to analyse bacterial community composition, its application in parasitological research remains limited. What interest there has been has focused on previously intractable research settings where traditional methods are inappropriate, for example, in longitudinal studies and studies involving endangered species. In settings such as these, non-invasive sampling combined with metabarcoding can provide a fast and accurate assessment of component communities. In this paper we review the use of metabarcoding in the study of helminth communities in wild mammals, outlining the necessary procedures from sample collection to statistical analysis...
May 23, 2017: Parasitology
https://www.readbyqxmd.com/read/28534320/infectious-keratitis-and-orthokeratology-lens-use-a-systematic-review
#13
REVIEW
Ka Wai Kam, Wing Yung, Gabriel Ka Hin Li, Li Jia Chen, Alvin L Young
PURPOSE: Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. METHODS: We searched in the PubMed and EMBASE for articles adopting the search strategy "(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR cornea ulcer OR microbial keratitis OR bacterial keratitis)", from the start date of the databases to August 23, 2016...
May 22, 2017: Infection
https://www.readbyqxmd.com/read/28534277/how-do-small-groups-make-decisions-a-theoretical-framework-to-inform-the-implementation-and-study-of-clinical-competency-committees
#14
Saad Chahine, Sayra Cristancho, Jessica Padgett, Lorelei Lingard
In the competency-based medical education (CBME) approach, clinical competency committees are responsible for making decisions about trainees' competence. However, we currently lack a theoretical model for group decision-making to inform this emerging assessment phenomenon. This paper proposes an organizing framework to study and guide the decision-making processes of clinical competency committees.This is an explanatory, non-exhaustive review, tailored to identify relevant theoretical and evidence-based papers related to small group decision-making...
May 22, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/28534274/exploring-the-validity-of-proposed-transgenic-animal-models-of-attention-deficit-hyperactivity-disorder-adhd
#15
REVIEW
June Bryan de la Peña, Irene Joy Dela Peña, Raly James Custodio, Chrislean Jun Botanas, Hee Jin Kim, Jae Hoon Cheong
Attention-deficit/hyperactivity disorder (ADHD) is a common, behavioral, and heterogeneous neurodevelopmental condition characterized by hyperactivity, impulsivity, and inattention. Symptoms of this disorder are managed by treatment with methylphenidate, amphetamine, and/or atomoxetine. The cause of ADHD is unknown, but substantial evidence indicates that this disorder has a significant genetic component. Transgenic animals have become an essential tool in uncovering the genetic factors underlying ADHD. Although they cannot accurately reflect the human condition, they can provide insights into the disorder that cannot be obtained from human studies due to various limitations...
May 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28534272/braf-mutation-is-associated-with-an-improved-survival-in-glioma-a-systematic-review-and-meta-analysis
#16
REVIEW
Huy Gia Vuong, Ahmed M A Altibi, Uyen N P Duong, Hanh T T Ngo, Thong Quang Pham, Kar-Ming Fung, Lewis Hassell
Newly emerged molecular markers in gliomas provide prognostic values beyond the capabilities of histologic classification. BRAF mutation, especially BRAF V600E, is common in a subset of gliomas and may represent a potential prognostic marker. The aim of our study is to investigate the potential use of BRAF mutations on prognosis of glioma patients. Four electronic databases were searched for potential articles, including PubMed, Scopus, ISI Web of Science, and Virtual Health Library (VHL). Data of hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) were directly obtained from original papers or indirectly estimated from Kaplan Meier curve (KMC)...
May 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28534221/measuring-outcomes-in-adult-spinal-deformity-surgery-a-systematic-review-to-identify-current-strengths-weaknesses-and-gaps-in-patient-reported-outcome-measures
#17
REVIEW
Sayf S A Faraj, Miranda L van Hooff, Roderick M Holewijn, David W Polly, Tsjitske M Haanstra, Marinus de Kleuver
PURPOSE: Adult spinal deformity (ASD) causes severe disability, reduces overall quality of life, and results in a substantial societal burden of disease. As healthcare is becoming more value based, and to facilitate global benchmarking, it is critical to identify and standardize patient-reported outcome measures (PROMs). This study aims to identify the current strengths, weaknesses, and gaps in PROMs used for ASD. METHODS: Studies were included following a systematic search in multiple bibliographic databases between 2000 and 2015...
May 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28534073/surgical-treatment-of-intraforaminal-extraforaminal-lumbar-disc-herniations-many-approaches-for-few-surgical-routes
#18
REVIEW
Giorgio Lofrese, Lorenzo Mongardi, Francesco Cultrera, Giorgio Trapella, Pasquale De Bonis
BACKGROUND: Several disc disease nomenclatures and approaches for LDH exist. The traditional midline bone-destructive procedures together with approaches requiring extreme muscular retraction are being replaced by muscle sparing, targeted, stability-preserving surgical routes. The increasing speculation on LDHs and the innovative corridors described to treat them have lead to an extensive production of papers frequently treating the same topic but adopting different terminologies and reporting contradictory results...
May 22, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28534010/autophagy-in-the-placenta
#19
REVIEW
Soo-Young Oh, Cheong-Rae Roh
Autophagy is an evolutionarily conserved catalytic process by which cytoplasmic components including damaged macromolecules and organelles are degraded. The role of autophagy includes adaptive responses to nutrition deprivation or intracellular stimuli. Although autophagosomes were first observed in early 1960s, it was 1990s that autophagy-related genes in yeast were identified and studied. Nowadays, the molecular machinery of autophagy and signaling pathway to various stimuli are almost outlined. Dysregulation of autophagic activity has been implicated in many human diseases including neurodegenerative diseases, infection and inflammation, and malignancies...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28533971/regression-assumptions-in-clinical-psychology-research-practice-a-systematic-review-of-common-misconceptions
#20
Anja F Ernst, Casper J Albers
Misconceptions about the assumptions behind the standard linear regression model are widespread and dangerous. These lead to using linear regression when inappropriate, and to employing alternative procedures with less statistical power when unnecessary. Our systematic literature review investigated employment and reporting of assumption checks in twelve clinical psychology journals. Findings indicate that normality of the variables themselves, rather than of the errors, was wrongfully held for a necessary assumption in 4% of papers that use regression...
2017: PeerJ
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