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https://www.readbyqxmd.com/read/28938797/revisiting-the-safety-of-aspartame
#1
Arbind Kumar Choudhary, Etheresia Pretorius
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. Since 1981, when aspartame was first approved by the US Food and Drug Administration, researchers have debated both its recommended safe dosage (40 mg/kg/d) and its general safety to organ systems. This review examines papers published between 2000 and 2016 on both the safe dosage and higher-than-recommended dosages and presents a concise synthesis of current trends...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938731/the-importance-of-genetic-parenthood-for-infertile-men-and-women
#2
S Hendriks, K Peeraer, H Bos, S Repping, E A F Dancet
STUDY QUESTION: Do men and women beginning to attend a fertility clinic prefer genetic over non-genetic parenthood? SUMMARY ANSWER: Nearly, all infertile men and women prefer genetic parenthood. WHAT IS KNOWN ALREADY: Clinicians assume that all infertile couples prefer genetic parenthood over non-genetic parenthood and, therefore, consider treatments with donor gametes an option of last resort. Previous studies of the desire for parenthood identified 30 motivations for genetic parenthood, and 51 motivations for which having a genetically related child is not strictly necessary but might be deemed required...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938128/contralateral-axillary-lymph-node-metastasis-in-second-primary-breast-cancer-case-report-and-review-of-the-literature
#3
Jacob Gingerich, Edna Kapenhas, Jack Morgani, Alan Heimann
The rare entity of contra-lateral axillary lymph node metastasis(CAM) has been a debatable topic in the realm of breast cancer management for many years. There remains controversy over whether CAM should be considered distant metastasis or locoregional spread. It is also uncertain why or how CAM occurs. In this case report and review of the literature, we present an 81-year-old female with an apparent second primary breast cancer with synchronous CAM. This paper describes a scenario of altered lymphatic drainage which likely lead to CAM...
August 25, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28938105/how-people-from-ethnic-minorities-describe-their-experiences-of-managing-type-2-diabetes-mellitus-a-qualitative-meta-synthesis
#4
REVIEW
Virginia Jones, Marie Crowe
BACKGROUND: The increasing prevalence of diabetes is well-documented along with the findings that some ethnic minorities have a higher prevalence than non-minority individuals. Along with possible biological differences between ethnicities, access to economic, social, cultural and symbolic capital may impact on the success of managing type-2 diabetes. OBJECTIVES: To examine how people from ethnic minorities in Western countries describe their experiences of managing type-2 diabetes mellitus...
August 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28938098/an-integrative-review-on-conflict-management-styles-among-nursing-students-implications-for-nurse-education
#5
REVIEW
Leodoro J Labrague, Denise M McEnroe-Petitte
OBJECTIVES: Nurse education plays a critical role in the achievement of conflict management skills in nursing students. However, a wider perspective on this concept has not been explored. This paper is a report of a review appraising and synthesizing existing empirical studies describing conflict management styles among nursing students. DESIGN: An integrative review method guided this review. DATA SOURCES: Five (5) bibliographic databases (CINAHL, Medline, Psych Info, Embase and SCOPUS) were searched to locate relevant articles...
September 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28937891/barriers-and-drawbacks-of-the-assessment-of-dental-fear-dental-anxiety-and-dental-phobia-in-children-a-critical-literature-review
#6
N A Aminabadi, Marzieh Shokravi, Zahra Jamali, Sajjad Shirazi
OBJECTIVE: Dental anxiety, fear and phobia have different etiology, response patterns, time courses, and intensities that justify a clear distinction between these constructs. Differentiation of dental anxiety, fear or phobia in practice is a critical prerequisite for developing and implementing effective treatment for children. The aim of this study was to investigate whether current researches in the pediatric dentistry appropriately discriminate the central construct of dental anxiety, fear and phobia...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937778/-changes-of-the-who-classification-of-myeloid-neoplasms-in-the-context-of-the-2016-revision
#7
Juraj Marcinek, Tomáš Balhárek, Lukáš Plank
Continual progress of knowleges in hematopathology and genetics of hematologic tumors requires actualisation of widely accepted and presently used WHO classification of myeloid neoplasms published 8 years ago. However, the basic principles of this classification remain unchanged, therefore the authors of new WHO classification mention the "revision" of previous and not the introduction o new classification. The aim of this paper is to outline the most important changes of myeloid neoplasm diagnostics to pathologists, hematologists and other clinicians in Czech Republic and Slovakia...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28937462/instability-in-thoracolumbar-trauma-is-a-new-definition-warranted
#8
Salman Abbasi Fard, Jesse Skoch, Mauricio J Avila, Apar S Patel, Kamran V Sattarov, Christina M Walter, Ali A Baaj
STUDY DESIGN: Review of the articles. OBJECTIVE: The objective of this study was to review all articles related to spinal instability to determine a consensus statement for a contemporary, practical definition applicable to thoracolumbar injuries. SUMMARY OF BACKGROUND DATA: Traumatic fractures of the thoracolumbar spine are common. These injuries can result in neurological deficits, disability, deformity, pain, and represent a great economic burden to society...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28936877/botryococcus-as-an-alternative-source-of-carotenoids-and-its-possible-applications-an-overview
#9
Ranga Rao Ambati, Deepika Gogisetty, Ravishankar Aswathnarayana Gokare, Sarada Ravi, Panduranga Narasimharao Bikkina, Yuepeng Su, Bo Lei
The enhanced interest in carotenoid research arises partly because of their application in the food and health industries and partly because of the necessity to find a commercially viable natural source for their mass production. The bottlenecks in finding a natural source of carotenoids which can compete with the synthetic products is the mass production of the organism that produces carotenoids, cell harvesting and extraction methods of carotenoids. The microalga Botryococcus braunii is an interesting organism for its commercial value as a rich source of carotenoids...
September 22, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28936834/-advances-of-toxicity-evaluation-of-cinnabar-and-compatibility-necessity-analysis
#10
REVIEW
Tong Ding, Jiao-Yang Luo, Xu Han, Shi-Hai Yang, Rui-Chao Lin, Mei-Hua Yang
Cinnabars are widely used in the clinic and shows unique efficacy, and it has been used in treating diseases for thousands of years either single-use or combination with other traditional Chinese medicines. Cinnabar mainly contains mercury, which displays obvious hepatotoxicity and nephrotoxicity. The safety of cinnabar and its rational use caused extensive attention. However, there are some misunderstanding that cinnabar shows equivalent toxicity to the toxicity of mercury compounds such as mercuric chloride and methylmercury in safety evaluation of cinnabar, which in our view exaggerates the toxicity...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936750/person-centered-care-and-personalized-medicine-irreconcilable-opposites-or-potential-companions
#11
Leila El-Alti, Lars Sandman, Christian Munthe
In contrast to standardized guidelines, personalized medicine and person centered care are two notions that have recently developed and are aspiring for more individualized health care for each single patient. While having a similar drive toward individualized care, their sources are markedly different. While personalized medicine stems from a biomedical framework, person centered care originates from a caring perspective, and a wish for a more holistic view of patients. It is unclear to what extent these two concepts can be combined or if they conflict at fundamental or pragmatic levels...
September 21, 2017: Health Care Analysis: HCA: Journal of Health Philosophy and Policy
https://www.readbyqxmd.com/read/28936421/a-conceptual-framework-to-assess-effectiveness-in-wheelchair-provision
#12
Deepan C Kamaraj, Nathan Bray, Karen Rispin, Padmaja Kankipati, Jonathan Pearlman, Johan Borg
BACKGROUND: Currently, inadequate wheelchair provision has forced many people with disabilities to be trapped in a cycle of poverty and deprivation, limiting their ability to access education, work and social facilities. This issue is in part because of the lack of collaboration among various stakeholders who need to work together to design, manufacture and deliver such assistive mobility devices. This in turn has led to inadequate evidence about intervention effectiveness, disability prevalence and subsequent costeffectiveness that would help facilitate appropriate provision and support for people with disabilities...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28936414/the-health-benefits-and-constraints-of-exercise-therapy-for-wheelchair-users-a-clinical-commentary
#13
Terry J Ellapen, Henriëtte V Hammill, Mariette Swanepoel, Gert L Strydom
BACKGROUND: There are approximately 1 billion people living with chronic lower limb disability, many of whom are wheelchair users. OBJECTIVES: Review cardiometabolic and neuromuscular risk profiles of wheelchair users, benefits of regular exercise and the causes of neuromuscular upper limb and hip injuries that hinder regular adherence. METHOD: Literature published between 2013 and 2017 was adopted according to the standard practices for systematic reviews (PRISMA) through Crossref Metadata and Google Scholar searches...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28936411/a-literature-review-on-work-transitioning-of-youth-with-disabilities-into-competitive-employment
#14
REVIEW
Madri Engelbrecht, Lynn Shaw, Lana van Niekerk
BACKGROUND: The marginalisation of youth with disabilities from employment opportunities is evident from literature in as far as they form part of the larger groups 'people with disabilities' and 'youth'. A focused view of programmes that assist youth with disabilities into employment has not been presented, despite the worldwide crisis of youth unemployment. AIM: This review aimed to identify evidence on work transition programmes that are effective in assisting people with disabilities into open labour market (competitive) employment, as well as to highlight gaps in knowledge to inform future research on this topic...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28936274/a-review-on-wax-printed-microfluidic-paper-based-devices-for-international-health
#15
REVIEW
S Altundemir, A K Uguz, K Ulgen
Paper-based microfluidics has attracted attention for the last ten years due to its advantages such as low sample volume requirement, ease of use, portability, high sensitivity, and no necessity to well-equipped laboratory equipment and well-trained manpower. These characteristics have made paper platforms a promising alternative for a variety of applications such as clinical diagnosis and quantitative analysis of chemical and biological substances. Among the wide range of fabrication methods for microfluidic paper-based analytical devices (μPADs), the wax printing method is suitable for high throughput production and requires only a commercial printer and a heating source to fabricate complex two or three-dimensional structures for multipurpose systems...
July 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28936141/social-frailty-in-older-adults-a-scoping-review
#16
REVIEW
S Bunt, N Steverink, J Olthof, C P van der Schans, J S M Hobbelen
Social frailty is a rather unexplored concept. In this paper, the concept of social frailty among older people is explored utilizing a scoping review. In the first stage, 42 studies related to social frailty of older people were compiled from scientific databases and analyzed. In the second stage, the findings of this literature were structured using the social needs concept of Social Production Function theory. As a result, it was concluded that social frailty can be defined as a continuum of being at risk of losing, or having lost, resources that are important for fulfilling one or more basic social needs during the life span...
September 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28935774/immunotherapy-a-new-and-old-approach-to-treatment-of-soft-tissue-and-bone-sarcomas
#17
REVIEW
Michael J Nathenson, Anthony P Conley, Edward Sausville
Soft tissue and bone sarcomas are a rare and heterogeneous form of cancer. With standard of care treatment options including surgery, radiation, and chemotherapy, the long-term survival is still low for high-risk soft tissue sarcoma patients. New treatment strategies are needed. Immunotherapy offers a new potential treatment paradigm with great promise. Immunotherapy of soft tissue sarcomas dates back to Dr. Coley's first use of toxins in the late 1800s. A variety of strategies of immunotherapy have been tried in soft tissue and bone sarcomas, including various vaccines and cytokines, with limited success...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28935552/natural-products-applied-against-hydatid-cyst-protoscolices-a-review-of-past-to-present
#18
REVIEW
Mohammad Hasan Kohansal Koshki, Abbasali Nourian, Mohammad Taghi Rahimi, Ahmad Daryani, Adel Spotin, Ehsan Ahmadpour
Echinococcus granulosus is the causative agent of cystic echinococcosis (CE), which is distributed all around the world. CE is one of the most important global parasitic infectious diseases, both in humans and animals. This parasite causes hydatid cysts that can be lodge at different organs of host such as liver, lung even in heart and brain which may lead to death. Presently, numerous scolicidal chemical agents have been administrated for inactivation of the hydatid cyst contents. Because of increasing resistance and adverse effects of medications include abnormalities of liver function, abdominal pain, diarrhea, nausea, vomiting, dizziness, and headache; there is a need to find alternative therapies either with the least or without side effects...
September 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28935546/fluorescein-guided-resection-of-intramedullary-spinal-cord-tumors-results-from-a-preliminary-multicentric-retrospective-study
#19
Francesco Acerbi, Claudio Cavallo, Karl-Michael Schebesch, Mehmet Osman Akcakaya, Camilla de Laurentis, Mustafa Kemal Hamamcioglu, Morgan Broggi, Alexander Brawanski, Jacopo Falco, Roberto Cordella, Paolo Ferroli, Telat Kiris, Julius Höhne
INTRODUCTION: IMSCTs are rare heterogenous lesions usually enhancing at pre-operative MRI, due to a damaged BBB. SF is a dye that accumulates in areas of the CNS with a damaged BBB. Given the pattern of MRI contrast-enhancement of the majority of IMSCTs, the use of this fluorescent tracer could improve tumor visualization and quality of resection. In this paper, we present the first experience on the application of fluorescein-guided technique for surgical removal of IMSCTs. METHODS: 11 patients (6 males, 5 females, mean age 50...
September 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28935479/progressive-ratio-pr-schedules-and-the-sipometer-do-they-measure-wanting-liking-and-or-reward-a-tribute-to-anthony-sclafani-and-karen-ackroff
#20
H R Kissileff, M Herzog
This paper honors the contributions made by Anthony (Tony) Sclafani and Karen Ackroff to both the Columbia University Seminar on Appetitive Behavior and to the field of ingestive behavior in general. We review their use of the progressive ratio (PR) licking paradigm, to determine whether the taste of sucrose, independent of its post-ingestive effects, is always positively reinforcing in animals. They demonstrated a monotonic increase in licking as concentration increased, and obtained results identical to those obtained with a lever-pressing paradigm, but licking was easier and more natural than lever pressing...
September 18, 2017: Appetite
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