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review article NEJM

Mads Gilbert
BACKGROUND: The atrocities in Syria have been covered in the four general medical weekly journals in the USA and the UK. Medical journal articles addressing political determinants of public health have rightly described and criticised the international community's failure to enforce humanitarian law while urging global bodies of power to ensure protection of civilians and civilian infrastructure and medical services. Discussions of the political influences on health of people in the occupied Palestinian territory (West Bank and Gaza Strip) seem to be considered politically out-of-bounds by some medical journals...
February 21, 2018: Lancet
Sarah Tilstra, Melissa A McNeil
The goal in selecting these recent articles was to help identify literature that may change the clinical practice of women's health for internists. Articles were identified by reviewing the high-impact medical and women's health journals, national guidelines, ACP JournalWise, and NEJM Journal Watch. Cardiovascular (CV) disease remains the leading cause of death in women. The emphasis of this review is on identifying opportunities for CV risk reduction to prevent disease and on early identification of women with preexisting atherosclerotic disease to allow for early initiation of medical treatment...
February 2018: Journal of Women's Health
Julie De Meulemeester, Mark Fedyk, Lucas Jurkovic, Michael Reaume, Dar Dowlatshahi, Grant Stotts, Michel Shamy
OBJECTIVE: We have proposed that three scientific criteria are important for the ethical justification of randomized clinical trials (RCTs): (1) they should be designed around a clear hypothesis; (2) uncertainty should exist around that hypothesis; (3) that uncertainty should be as established through a systematic review. We hypothesized that the majority of a sample of recently published RCTs would not explicitly incorporate these criteria, therefore rendering them potentially unjustified on scientific grounds...
May 2018: Journal of Clinical Epidemiology
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
H Tremlett, R Lucas
BACKGROUND AND PURPOSE: We set out to revisit and comment on the evidence surrounding a popular figure published in the New England Journal of Medicine (2002), which suggests that the incidence of immune-mediated diseases, including multiple sclerosis (MS), is increased by reduced exposure to infections. METHODS: Commentary. RESULTS: We found that, to date (May 2017), this influential article has been cited >2000 times. However, on close investigation of the figure, we noticed some problems...
January 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ronald E Delanois, Chukwuweike U Gwam, Nicolas S Piuzzi, Morad Chughtai, Arthur L Malkani, Peter M Bonutti, Michael A Mont
BACKGROUND: Healthcare policy is often determined by well-designed studies most often published in high-impact medical journals. However, concern about the presence of publication bias against lower-extremity arthroplasty-related studies has called into question some of the validity of certain reports. There are only a few studies investigating the presence of the bias in high-impact medical journals against lower-extremity arthroplasty intervention, particularly in the Journal of American Medical Association (JAMA), New England Journal of Medicine (NEJM), and the Lancet...
February 2018: Journal of Arthroplasty
Olfa Ferchichi, Najoua Derbel, Nejm-Eddine Jaidane, Thibaud Cours, Alexander Alijah
There has been a disagreement amongst experimentalists and between experimentalists and theoreticians as to the gas-phase structure of dimethyl peroxide. We have investigated this problem with high-level CCSD(T)-F12 and MRCI procedures. There can be no doubt anymore that, at the minimum of the potential energy surface, the COOC fragment has a trans-structure. The dynamical structure of the molecule can, however, be different and be explained by the very slow torsional motion. We have analysed the dynamical structure using numerical wavefunctions of the torsional motion and a fully optimized potential curve of MP2/aug-cc-pVTZ quality...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
M Gosho, Y Sato, K Nagashima, S Takahashi
WHAT IS KNOWN AND OBJECTIVE: Study design and statistical methods have become core components of medical research, and the methodology has become more multifaceted and complicated over time. The study of the comprehensive details and current trends of study design and statistical methods is required to support the future implementation of well-planned clinical studies providing information about evidence-based medicine. Our purpose was to illustrate study design and statistical methods employed in recent medical literature...
February 2018: Journal of Clinical Pharmacy and Therapeutics
Jennifer S Gewandter, Rachel A Kitt, Matthew R Hunsinger, Joseph Poku, Jacqueline Lozano, Jenna Chaudari, Scott Evans, Robert A Gross, Michael P McDermott, Michael C Rowbotham, Dennis C Turk, Robert H Dworkin
OBJECTIVE: To examine whether primary reports of randomized clinical trials (RCTs) in six high-impact, general medical journals reported (1) whether or not a Data Monitoring Committee/Data and Safety Monitoring Board (DMC/DSMB) was used and (2) the composition of the responsibilities of the reported DSMB/DMCs. STUDY DESIGN AND SETTING: Systematic review of RCTs published in 2014 in Annals of Internal Medicine, BMJ, NEJM, JAMA, JAMA Internal Medicine, and Lancet...
March 2017: Journal of Clinical Epidemiology
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
December 2016: Quality of Life Research
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of data monitoring committees (DMCs), the frequency of interim analysis, prespecified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high-impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
January 2017: Acta Paediatrica
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2015: New England Journal of Medicine
Anthony J Scillia, James D McDermott, Kimona Issa, Peter Goljan, Steven F Harwin, Anthony Festa, Vincent K McInerney
Arthroscopic partial meniscectomy (APM) has been demonstrated to be effective when performed in the appropriately indicated patient. However, a recent study published in the New England Journal of Medicine (NEJM) questioned whether or not the procedure actually had any clinical benefit whatsoever. Despite being a prospective, Level 1, randomized study, there are several aspects of the study that must be taken into consideration when interpreting the findings, including but not limited to the patient selection criteria, limited sample size, and lack of information regarding meniscal tear patterns...
July 2016: Journal of Knee Surgery
(no author information available yet)
Pandemic Preparedness and Response - Lessons from the H1N1 Influenza of 2009 Review Article, N Engl J Med 2014;370:1335-1342. In the "Time Course of the 2009 H1N1 Pandemic" section, in the first paragraph under "World Health Organization" (page 1337), the third sentence should have begun, "The organization provided guidance to inform national influenza-preparedness plans, which were in place in 74% of countries . . ." rather than, ". . . in 74 countries . . . ." The article is correct at
January 8, 2015: New England Journal of Medicine
(no author information available yet)
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease Review Article, N Engl J Med 2014;371:1131-1141. In the legend for Figure 2 (page 1134), the third sentence should have read, "Activated PKCε binds to and inhibits the insulin receptor tyrosine kinase, leading to decreased insulin-stimulated glycogen synthesis in the liver owing to decreased phosphorylation of GSK3," rather than ". . . leading to decreased insulin-stimulated glycogen synthesis in the liver through increased glycogen synthase kinase 3 (GSK3) phosphorylation...
December 4, 2014: New England Journal of Medicine
V Krishnan, D Kejariwal
INTRODUCTION: Medical 'ward round' (WR) is a complex clinical process and a key component of daily hospital activity. Despite this, there is a clear paucity of quality indicators and evidence base for best practice for WR with considerable variability in the efficiency and quality. This prompted us to devise and implement a ward round checklist (WRC)based on the Royal College of Physicians (RCP) and Nursing (RCN) ([1]) to improve quality of inpatient care. METHODS: We developed the WRC (Figure 1) for a comprehensive patient review, got approved by the hospital health records committee and used as a sticky note in clinical notes...
June 2014: Gut
(no author information available yet)
Primary Hyperoxaluria Review Article, N Engl J Med 2013;369:649-658. In the introduction (page 649), the first sentence of the second paragraph should have read, "Oxalate, in the form of its calcium salt, is a highly insoluble end product of metabolism in humans," rather than "Oxalate, a dicarboxylic acid (HOOC-COOH), is a highly insoluble . . . ." The article is correct at
November 28, 2013: New England Journal of Medicine
(no author information available yet)
Severe Sepsis and Septic Shock Review Article, N Engl J Med 2013;369:840-851. In Table 2 (page 846), the grade given for "Continue fluid-challenge technique as long as there is hemodynamic improvement" (row 6 under Resuscitation) should have been UG, rather than 1C. The article is correct at
November 21, 2013: New England Journal of Medicine
(no author information available yet)
Global Health: Response to the AIDS Pandemic - A Global Health Model Review Article, N Engl J Med 2013;368:2210-2218. In Figure 1 (page 2212), the estimated HIV prevalence in Gabon should have been shown as 5.0 to <15.0%, rather than 15 to <28%. The article is correct at
August 29, 2013: New England Journal of Medicine
(no author information available yet)
Enteropathogens and Chronic Illness in Returning Travelers Review Article, N Engl J Med 2013;368:1817-1825. In Table 1 (page 1819), the images for Entamoeba histolytica and Strongyloides were transposed. The article is correct at
May 9, 2013: New England Journal of Medicine
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