keyword
MENU ▼
Read by QxMD icon Read
search

review NEJM

keyword
https://www.readbyqxmd.com/read/28050393/metronomic-chemotherapy-seems-prowess-to-battle-against-cancer-in-current-scenario
#1
Prema Muthusamy, Krishnan Vengadaragava Chary, G K Nalini
INTRODUCTION: Metronomic chemotherapy is an emerging method of chemotherapy. Metronomic 'lowdose' chemotherapy regimen induces tumour dormancy and reduces cancer resistance against anticancer drugs. It tends to improve overall success rate of cancer chemotherapy than conventional cyclical regimen. AIM: The aim of this systemic review was to provide comprehensive data of metronomic chemotherapy trials, regimens used and it's outcome in cancer therapeutics. MATERIALS AND METHODS: Fifty chemotherapy trial data were searched sequentially from web...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28027060/methodological-quality-of-surgical-mortality-studies-using-large-hospital-databases-a-systematic-review
#2
Cécile Payet, Jean-Christophe Lifante, Matthew J Carty, Muriel Rabilloud, Antoine Duclos
OBJECTIVE: To review the methodology employed in surgical mortality studies to control for potential confounders. SUMMARY BACKGROUND DATA: Nationwide hospital data are increasingly used to investigate surgical outcomes. However, poor data granularity and coding inaccuracies may lead to flawed findings. METHODS: We conducted a systematic review in accordance with the PRISMA statement in 6 major journals (NEJM, Lancet, BMJ, JAMA, Medical Care, Annals of Surgery) using PubMed from its inception until December 31, 2014...
December 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27979724/a-peer-reviewed-instructional-video-is-as-effective-as-a-standard-recorded-didactic-lecture-in-medical-trainees-performing-chest-tube-insertion-a-randomized-control-trial
#3
Tomas J Saun, Scott Odorizzi, Celine Yeung, Marjorie Johnson, Glen Bandiera, Shelly P Dev
OBJECTIVE: Online medical education resources are becoming an increasingly used modality and many studies have demonstrated their efficacy in procedural instruction. This study sought to determine whether a standardized online procedural video is as effective as a standard recorded didactic teaching session for chest tube insertion. DESIGN: A randomized control trial was conducted. Participants were taught how to insert a chest tube with either a recorded didactic teaching session, or a New England Journal of Medicine (NEJM) video...
December 12, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27753830/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#4
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27650288/reporting-and-dealing-with-missing-quality-of-life-data-in-rcts-has-the-picture-changed-in-the-last-decade
#5
REVIEW
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
December 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27642883/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#6
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27637413/reporting-on-data-monitoring-committees-in-neonatal-randomised-controlled-trials-is-inconsistent
#7
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of data monitoring committees (DMCs), the frequency of interim analysis, prespecified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high-impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
January 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27470506/reporting-quality-of-randomised-controlled-trial-abstracts-among-high-impact-general-medical-journals-a-review-and-analysis
#8
Meredith Hays, Mary Andrews, Ramey Wilson, David Callender, Patrick G O'Malley, Kevin Douglas
OBJECTIVE: The aim of this study was to assess adherence to the Consolidated Standards of Reporting Trials (CONSORT) for Abstracts by five high-impact general medical journals and to assess whether the quality of reporting was homogeneous across these journals. DESIGN: This is a descriptive, cross-sectional study. SETTING: Randomised controlled trial (RCT) abstracts in five high-impact general medical journals. PARTICIPANTS: We used up to 100 RCT abstracts published between 2011 and 2014 from each of the following journals: The New England Journal of Medicine (NEJM), the Annals of Internal Medicine (Annals IM), The Lancet, the British Medical Journal (The BMJ) and the Journal of the American Medical Association (JAMA)...
July 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/26650174/ischemic-optic-neuropathies
#9
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26378905/arthroscopic-partial-meniscectomy-for-meniscal-tears-a-review-and-commentary-on-a-study-by-nejm
#10
Anthony J Scillia, James D McDermott, Kimona Issa, Peter Goljan, Steven F Harwin, Anthony Festa, Vincent K McInerney
Arthroscopic partial meniscectomy (APM) has been demonstrated to be effective when performed in the appropriately indicated patient. However, a recent study published in the New England Journal of Medicine (NEJM) questioned whether or not the procedure actually had any clinical benefit whatsoever. Despite being a prospective, Level 1, randomized study, there are several aspects of the study that must be taken into consideration when interpreting the findings, including but not limited to the patient selection criteria, limited sample size, and lack of information regarding meniscal tear patterns...
July 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/26378444/results-of-vertebral-augmentation-treatment-for-patients-of-painful-osteoporotic-vertebral-compression-fractures-a-meta-analysis-of-eight-randomized-controlled-trials
#11
Lianhua Li, Jixin Ren, Jia Liu, Hao Wang, Xiaowei Wang, Zhi Liu, Tiansheng Sun
BACKGROUND: In 2009 two RCTs were publicated to question the efficacy of vertebroplasty comparing with sham treatment (ST) in the New England Journal of Medicine (NEJM), which provoked an academic debate on the efficacy of PVA. The purposes of our study were to compare clinical differences in pain relief, spinal functional outcomes, and overall quality of life between PVA and CT for painful osteoporotic VCFs. METHODS: We searched PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and Web of Knowledge from January 1980 to June 2013 with Medical Subject Headings terms and keywords...
2015: PloS One
https://www.readbyqxmd.com/read/26100188/screening-mammography-update-and-review-of-publications-since-our-report-in-the-new-england-journal-of-medicine-on-the-magnitude-of-the-problem-in-the-united-states
#12
REVIEW
Archie Bleyer
RATIONALE AND OBJECTIVES: After a half century of clinical trials, expansive observations, vigorous advocacy and debate, screening mammography could not be in a more controversial condition, especially the potential harm of overdiagnosis. Despite a simple rationale (catch the cancer early and either prevent death or at least decrease the amount of therapy needed for cure), the estimates to date of overdiagnosis rates are conflicting and the interpretations complex. MATERIALS AND METHODS: Since the author's 2012 publication in the New England Journal of Medicine (NEJM), the peer-reviewed publications on overdiagnosis caused by screening mammography are reviewed and the NEJM analyses updated with three additional calendar years of results...
August 2015: Academic Radiology
https://www.readbyqxmd.com/read/25564919/pandemic-preparedness-and-response-lessons-from-the-h1n1-influenza-of-2009
#13
(no author information available yet)
Pandemic Preparedness and Response - Lessons from the H1N1 Influenza of 2009 Review Article, N Engl J Med 2014;370:1335-1342. In the "Time Course of the 2009 H1N1 Pandemic" section, in the first paragraph under "World Health Organization" (page 1337), the third sentence should have begun, "The organization provided guidance to inform national influenza-preparedness plans, which were in place in 74% of countries . . ." rather than, ". . . in 74 countries . . . ." The article is correct at NEJM.org.
January 8, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25470714/ectopic-fat-in-insulin-resistance-dyslipidemia-and-cardiometabolic-disease
#14
(no author information available yet)
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease Review Article, N Engl J Med 2014;371:1131-1141. In the legend for Figure 2 (page 1134), the third sentence should have read, "Activated PKCε binds to and inhibits the insulin receptor tyrosine kinase, leading to decreased insulin-stimulated glycogen synthesis in the liver owing to decreased phosphorylation of GSK3," rather than ". . . leading to decreased insulin-stimulated glycogen synthesis in the liver through increased glycogen synthase kinase 3 (GSK3) phosphorylation...
December 4, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/25021765/pth-074%C3%A2-transforming-ward-rounds
#15
V Krishnan, D Kejariwal
INTRODUCTION: Medical 'ward round' (WR) is a complex clinical process and a key component of daily hospital activity. Despite this, there is a clear paucity of quality indicators and evidence base for best practice for WR with considerable variability in the efficiency and quality. This prompted us to devise and implement a ward round checklist (WRC)based on the Royal College of Physicians (RCP) and Nursing (RCN) ([1]) to improve quality of inpatient care. METHODS: We developed the WRC (Figure 1) for a comprehensive patient review, got approved by the hospital health records committee and used as a sticky note in clinical notes...
June 2014: Gut
https://www.readbyqxmd.com/read/24283246/primary-hyperoxaluria
#16
(no author information available yet)
Primary Hyperoxaluria Review Article, N Engl J Med 2013;369:649-658. In the introduction (page 649), the first sentence of the second paragraph should have read, "Oxalate, in the form of its calcium salt, is a highly insoluble end product of metabolism in humans," rather than "Oxalate, a dicarboxylic acid (HOOC-COOH), is a highly insoluble . . . ." The article is correct at NEJM.org.
November 28, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/24256399/severe-sepsis-and-septic-shock
#17
(no author information available yet)
Severe Sepsis and Septic Shock Review Article, N Engl J Med 2013;369:840-851. In Table 2 (page 846), the grade given for "Continue fluid-challenge technique as long as there is hemodynamic improvement" (row 6 under Resuscitation) should have been UG, rather than 1C. The article is correct at NEJM.org.
November 21, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23988148/global-health-response-to-the-aids-pandemic-a-global-health-model
#18
(no author information available yet)
Global Health: Response to the AIDS Pandemic - A Global Health Model Review Article, N Engl J Med 2013;368:2210-2218. In Figure 1 (page 2212), the estimated HIV prevalence in Gabon should have been shown as 5.0 to <15.0%, rather than 15 to <28%. The article is correct at NEJM.org.
August 29, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23699557/lung-volume-reduction-surgery-lvrs-since-the-nett-review-of-the-sts-database-from-2003-2011
#19
James Maloney, Nicole Strieter, Jeffrey Havlena
SESSION TYPE: Thoracic Surgery IPRESENTED ON: Monday, October 22, 2012 at 11:15 AM - 12:30 PMPURPOSE: The National Emphysema Treatment Trial established the efficacy of LVRS and defined the target patient population. Now, a decade since accrual for this landmark trial ended, the volume of LVRS performed in the United States remains remarkably low. LVRS is limited to JCHO certified sites and approved lung transplant centers which may reduce utilization but ensures rigorous monitoring of outcomes of the procedure...
October 1, 2012: Chest
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"