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https://www.readbyqxmd.com/read/28074603/supplementing-diet-with-manitoba-lingonberry-juice-reduces-kidney-ischemia-reperfusion-injury
#1
Cara K Isaak, Pengqi Wang, Suvira Prashar, Karmin O, Daniel C W Brown, Samir C Debnath, Yaw L Siow
BACKGROUND: Lingonberry (Vaccinium vitis-idaea L.) contains high levels of anthocyanins which are bioavailable in the kidney and may be protective against ischemia-reperfusion (IR)-induced acute kidney injury. This study investigated the effect of lingonberry juice on IR-induced stress-activated signaling pathway and inflammatory response in the kidney. RESULTS: Sprague-Dawley rats subjected to kidney IR had significantly impaired kidney function, with increased activation of the JNK signaling pathway and increased inflammatory response, measured using a multiplex panel containing an extensive array of inflammatory biomarkers...
January 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28068998/a-qualitative-study-on-african-immigrant-and-refugee-families-experiences-of-accessing-primary-health-care-services-in-manitoba-canada-it-s-not-easy
#2
Roberta Lynn Woodgate, David Shiyokha Busolo, Maryanne Crockett, Ruth Anne Dean, Miriam R Amaladas, Pierre J Plourde
BACKGROUND: Immigrant and refugee families form a growing proportion of the Canadian population and experience barriers in accessing primary health care services. The aim of this study was to examine the experiences of access to primary health care by African immigrant and refugee families. METHODS: Eighty-three families originating from 15 African countries took part in multiple open ended interviews in western Canada. Qualitative data was collected in six different languages between 2013 and 2015...
January 9, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28050139/report-from-the-17th-annual-western-canadian-gastrointestinal-cancer-consensus-conference-edmonton-alberta-11-12-september-2015
#3
K E Mulder, S Ahmed, J D Davies, C M Doll, S Dowden, S Gill, V Gordon, P Hebbard, H Lim, A McFadden, J P McGhie, J Park, R Wong
The 17th annual Western Canadian Gastrointestinal Cancer Consensus Conference (wcgccc) was held in Edmonton, Alberta, 11-12 September 2015. The wcgccc is an interactive multidisciplinary conference attended by health care professionals from across Western Canada (British Columbia, Alberta, Saskatchewan, and Manitoba) who are involved in the care of patients with gastrointestinal cancer. Surgical, medical, and radiation oncologists; pathologists; radiologists; and allied health care professionals participated in presentation and discussion sessions for the purposes of developing the recommendations presented here...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28050135/the-risk-of-colorectal-cancer-is-not-increased-after-a-diagnosis-of-urothelial-cancer-a-population-based-study
#4
C H Harlos, H Singh, Z Nugent, A Demers, S M Mahmud, P M Czaykowski
BACKGROUND: The data about whether patients with a prior urothelial cancer (uca) are at increased risk of colorectal cancer (crc) are conflicting. We used a competing risks analysis to determine the risk of crc after uca. METHODS: Historical cohorts were assembled by record linkage of Manitoba Cancer Registry and Manitoba Health databases. The incidence of crc for individuals with uca as their first cancer between 1987 and 2009 was compared with the incidence for randomly selected age-and sex-matched individuals without a cancer diagnosis at the index date (uca diagnosis date)...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28026717/outcomes-of-an-investment-in-administrative-data-infrastructure-an-example-of-capacity-building-at-the-manitoba-centre-for-health-policy
#5
Justine Orr, Mark Smith, Charles Burchill, Alan Katz, Randy Fransoo
Using the Manitoba Centre for Health Policy as an example, this commentary discusses how even small investments in population health data can create a multitude of research benefits. The authors highlight that through infrastructure development such as acquiring databases, facilitating access to data and developing data management practices, new, innovative research can be achieved at relatively low cost.
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28012378/systemic-inflammation-before-and-after-antiretroviral-therapy-initiation-as-a-predictor-of-immune-response-among-hiv-infected-individuals-in-manitoba
#6
Quinlan Richert, Adriana Trajtman, Luisa Arroyave, Julia Toews, Marissa Becker, Ken Kasper, Paul McLaren, Zulma Rueda, Yoav Keynan
INTRODUCTION: Despite the life-prolonging effects of Highly Active Antiretroviral Therapy (HAART), persons with HIV are still prone to higher rates of non-AIDS related morbidity (such as heart, kidney, and liver disease) than the general public. This is likely due to chronic immune activation and inflammation that persists in HIV-positive persons despite virological suppression. What remains undetermined, however, is whether a link exists between chronic inflammation/immune activation and suboptimal immune recovery on HAART...
December 21, 2016: Cytokine
https://www.readbyqxmd.com/read/27994449/an-evaluation-of-early-medication-use-for-copd-a-population-based-cohort-study
#7
Jamie Falk, Natalia Dik, Shawn Bugden
PURPOSE: The aim of this study was to evaluate the first initiation, sequence of addition, and appropriate prescribing of COPD medications in Manitoba, Canada. PATIENTS AND METHODS: A population-based cohort study of COPD medication use was conducted using administrative health care data (1997-2012). Those aged ≥35 years with COPD based on three or more COPD-related outpatient visits over a rolling 24-month window or at least one COPD-related hospitalization were included...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27989494/self-monitoring-of-blood-glucose-impact-of-quantity-limits-in-public-drug-formularies-on-provincial-costs-across-canada
#8
Sandra R Knowles, Kathy Lee, J Michael Paterson, Baiju R Shah, Muhammad M Mamdani, David N Juurlink, Tara Gomes
OBJECTIVES: For most patients with diabetes, routine use of blood glucose test strips (BGTS) has not been shown to be beneficial, yet the economic implications of broad publicly funded reimbursement for BGTS are substantial. We assessed the potential impact of BGTS quantity limits on utilization and costs for 6 publicly funded drug plans across Canada. METHODS: A cross-sectional analysis was conducted in 6 provinces (Alberta, Saskatchewan, Manitoba, Nova Scotia, Newfoundland and Labrador and Prince Edward Island) for patients who received at least 1 prescription for BGTS in 2014 through the public drug program...
December 15, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27975075/retrospective-study-investigating-the-seroprevalence-of-anaplasma-phagocytophilum-in-manitoba-canada-2011-2014
#9
Kamran Kadkhoda, Ainsley Gretchen
Human granulocytic anaplasmosis is currently not nationally notifiable in Canada. This for the most part accounts for gross under-estimation of true incidence and prevalence of HGA and would potentially culminate in clinical missed opportunities. To the best of our knowledge, this is the first report on the seroprevalence of Anaplasma phagocytophilum in a Canadian jurisdiction with known established black-legged tick populations.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27938959/six-year-prevalence-and-incidence-of-diabetic-retinopathy-and-cost-effectiveness-of-tele-ophthalmology-in-manitoba
#10
Raageen Kanjee, Ravi I Dookeran, Mathen K Mathen, Frank A Stockl, Richard Leicht
OBJECTIVE: The purpose of this study was to evaluate the diabetic retinopathy (DR) tele-ophthalmology screening program in Manitoba to determine prevalence and incidence of DR, as well as to estimate the program's cost-effectiveness. DESIGN: Retrospective chart review. PARTICIPANTS: A total of 4676 patients with type 2 diabetes examined 9334 times from 2007 to 2013. METHODS: Focused ophthalmic histories were recorded and examinations were performed by trained nurses, including visual acuities, intraocular pressure, and mydriatic 7 standard field stereoscopic fundus photography...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27938641/kivalliq-inuit-centre-boarding-home-and-the-provision-of-prenatal-education
#11
Karen M Lawford, Audrey R Giles
The Kivalliq Inuit Centre (KIC), a boarding home in Winnipeg, Manitoba, is unique in its provision of a pilot prenatal education class and public health nursing services for Nunavummiut who are beneficiaries of the Nunavut Land Claim Agreement. Through a critical review of literature, policies and interviews related to evacuation for birth, we argue that the pilot at the KIC has the potential to play an important role in improving maternal child health for residents of Nunavut.
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27933656/change-in-trabecular-bone-score-tbs-with-antiresorptive-therapy-does-not-predict-fracture-in-women-the-manitoba-bmd-cohort
#12
William D Leslie, Sumit R Majumdar, Suzanne N Morin, Didier Hans, Lisa M Lix
Bone mineral density (BMD) and trabecular bone score (TBS), along with additional clinical risk factors, can be used to identify individuals at high fracture risk. Whether change in TBS in untreated or treated women independently affects fracture risk is unclear. Using the Manitoba (Canada) DXA Registry containing all BMD results for the population we identified 9044 women age ≥40 years with two consecutive DXA scans and who were not receiving osteoporosis treatment at baseline (baseline mean age 62 ± 10 years)...
December 8, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27899401/neonatal-and-childhood-neurodevelopmental-health-and-educational-outcomes-of-children-exposed-to-antidepressants-and-maternal-depression-during-pregnancy-protocol-for-a-retrospective-population-based-cohort-study-using-linked-administrative-data
#13
Deepa Singal, Marni Brownell, Dan Chateau, Chelsea Ruth, Laurence Y Katz
INTRODUCTION: Antidepressants are commonly prescribed during pregnancy; however, there are inconsistent data on the safety of these medications during the prenatal period. To address this gap, this study will investigate short-term and long-term neurodevelopmental, physical and mental health, and educational outcomes of children who have been exposed to selective serotonin reuptake inhibitors (SSRIs) or selective serotonin norepinephrine reuptake inhibitors (SNRIs) and/or maternal depression during pregnancy...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27898799/effects-of-dolomitic-limestone-application-on-zinc-speciation-in-boreal-forest-smelter-contaminated-soils
#14
Jordan G Hamilton, Richard E Farrell, Ning Chen, Joel Reid, Renfei Feng, Derek Peak
Anthropogenic activities at the HudBay Minerals, Inc., Flin Flon (Manitoba, Canada) mining and processing facility have severely affected the surrounding boreal forest ecosystem. Soil contamination occurred via a combination of metal and sulfuric acid deposition and has resulted in forest dieback and ineffective natural recovery. A community-led effort to revegetate areas of the landscape through the application of a dolomitic limestone has been met with varied success. Zinc (Zn) speciation has shown to be closely linked to the presence or absence of an invasive metal-tolerant grass species, with soils being broadly classed into two revegetation response groups...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27866823/relative-risk-and-incidence-for-developmental-dysplasia-of-the-hip
#15
Virginie Pollet, Vanessa Percy, Heather J Prior
OBJECTIVE: To determine the incidence and associated risk factors of developmental dysplasia of the hip (DDH) in a modern population without universal screening. STUDY DESIGN: Children with DDH were identified from the Manitoba Centre for Health Policy's Data Repository by the use of International Classification of Diseases diagnosis codes as well as physician billing tariffs for surgical procedures for DDH for all children born between 1995 and 2012. To identify the outpatient-treated patients, ultrasound scans and radiographic imaging for DDH were reviewed for 2004-2012...
November 18, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27861712/trends-in-operative-and-nonoperative-hip-fracture-management-1990-2014-a-longitudinal-analysis-of-manitoba-administrative-data
#16
Peter Cram, Lin Yan, Eric Bohm, Paul Kuzyk, Lisa M Lix, Suzanne N Morin, Sumit R Majumdar, William D Leslie
OBJECTIVES: To evaluate longitudinal trends in the use of total hip arthroplasty (THA), hemiarthroplasty (HA), internal fixation (IF), and nonoperative management and to identify individual-level factors associated with nonoperative treatment of hip fracture (HF). DESIGN: Longitudinal analysis of administrative data. SETTING: Manitoba, Canada. PARTICIPANTS: All adults who experienced nontraumatic hip fractures between 1990 and 2014 (N = 19,626; mean age 80...
November 14, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27859612/objectively-verified-parental-non-hip-major-osteoporotic-fractures-and-offspring-osteoporotic-fracture-risk-a-population-based-familial-linkage-study
#17
Shuman Yang, William D Leslie, Randy Walld, Leslie L Roos, Suzanne N Morin, Sumit R Majumdar, Lisa M Lix
Parental hip fracture (HF) is associated with increased risk of offspring major osteoporotic fractures (MOFs; comprising hip, forearm, clinical spine or humerus fracture). Whether other sites of parental fracture should be used for fracture risk assessment is uncertain. The current study tested the association between objectively-verified parental non-hip MOF and offspring incident MOF. Using population-based administrative healthcare data for the province of Manitoba, Canada, we identified 255,512 offspring with linkage to at least one parent (238,054 mothers and 209,423 fathers)...
November 10, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27846193/predictors-of-emergency-department-use-by-persons-with-inflammatory-bowel-diseases-a-population-based-study
#18
Zoann Nugent, Harminder Singh, Laura E Targownik, Trevor Strome, Carolyn Snider, Charles N Bernstein
BACKGROUND: To describe the patterns and predictors of emergency department (ED) attendance and post-ED hospitalization by persons with inflammatory bowel disease (IBD). METHODS: We linked the University of Manitoba IBD Epidemiology Database with the Emergency Department Information System of the Winnipeg Regional Health Authority to determine the rates of presentation to the ED by persons with IBD from January 01, 2009 to March 31, 2012. Incident cases were diagnosed during the study period and all others were considered prevalent cases...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27845571/the-importance-of-taxonomic-resolution-for-additive-beta-diversity-as-revealed-through-dna-barcoding
#19
Trevor T Bringloe, Karl Cottenie, Gillian K Martin, Sarah J Adamowicz
Additive diversity partitioning (α, β, and γ) is commonly used to study the distribution of species-level diversity across spatial scales. Here, we first investigate whether published studies of additive diversity partitioning show signs of difficulty attaining species-level resolution due to inherent limitations with morphological identifications. Second, we present a DNA barcoding approach to delineate specimens of stream caddisfly larvae (order Trichoptera) and consider the importance of taxonomic resolution on classical (additive) measures of beta (β) diversity...
December 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/27829100/trends-in-injury-outcomes-across-canadian-trauma-systems
#20
Lynne Moore, Henry Thomas Stelfox, David Evans, Sayed Morad Hameed, Natalie L Yanchar, Richard Simons, John Kortbeek, Gilles Bourgeois, Julien Clément, Alexis F Turgeon, François Lauzier
Importance: In response to the burden of injury, the structure of injury care has changed considerably across Canada in the past decade. However, little is known about how patient outcomes have evolved. Objective: To evaluate trends in mortality, hospital length of stay, and unplanned readmission in Canadian trauma systems between 2006 and 2012. Design, Setting, and Participants: A pan-Canadian retrospective cohort study was conducted among adults admitted for major injury to a Canadian level I or II trauma center between April 1, 2006, and March 31, 2012...
November 9, 2016: JAMA Surgery
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