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https://www.readbyqxmd.com/read/28927682/mgf-e-peptide-pretreatment-improves-the-proliferation-and-osteogenic-differentiation-of-bmscs-via-mek-erk1-2-and-pi3k-akt-pathway-under-severe-hypoxia
#1
Yongqiang Sha, Yonggang Lv, Zhiling Xu, Li Yang, Xiaoying Hao, Ruli Afandi
AIMS: Severe hypoxia always inhibits the cell proliferation, osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), and hinders bone defect repair. Herein we explored the effects of mechano-growth factor (MGF) E peptide on the proliferation and osteogenic differentiation of BMSCs under severe hypoxia. MATERIALS AND METHODS: CoCl2 was utilized to simulate severe hypoxia. MTS was used to detect cell viability. Cell proliferation was verified through flow cytometry and EdU assay...
September 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/28926865/effects-of-hypoxia-during-continuous-and-intermittent-exercise-on-glycaemic-control-and-selected-markers-of-vascular-function-in-type-1-diabetes
#2
Barbara Hall, Aleksandra Zebrowska, Tomasz Kaminski, Arkadiusz Stanula, Anna Robins
Objectives The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D). Methods 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise. Results T1D patients' glycaemia decreased in response to ExC (p<0...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926527/genistein-suppresses-aerobic-glycolysis-and-induces-hepatocellular-carcinoma-cell-death
#3
Sainan Li, Jingjing Li, Weiqi Dai, Qinghui Zhang, Jiao Feng, Liwei Wu, Tong Liu, Qiang Yu, Shizan Xu, Wenwen Wang, Xiya Lu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Xiaoming Fan, Wenhui Mo, Ling Xu, Chuanyong Guo
BACKGROUND: Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1α) levels and glycolysis in tumour cells are associated with an increased risk of mortality, cancer progression, and resistance to therapy. However, the effect of genistein on HIF-1α and glycolysis in hepatocellular carcinoma (HCC) is still unclear. METHODS: Cell viability, apoptosis rate, lactate production, and glucose uptake were measured in HCC cell lines with genistein incubation...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28926104/glucose-stimulates-intestinal-epithelial-crypt-proliferation-by-modulating-cellular-energy-metabolism
#4
Weinan Zhou, Deepti Ramachandran, Abdelhak Mansouri, Megan J Dailey
The intestinal epithelium plays an essential role in nutrient absorption, hormone release and barrier function. Maintenance of the epithelium is driven by continuous cell renewal by stem cells located in the intestinal crypts. The amount and type of diet influence this process and result in changes in the size and cellular make-up of the tissue. The mechanism underlying the nutrient-driven changes in proliferation is not known, but may involve a shift in intracellular metabolism that allows for more nutrients to be used to manufacture new cells...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28925397/coactosin-like-protein-clp-cotl1-suppresses-breast-cancer-growth-through-activation-of-il-24-perp-and-inhibition-of-non-canonical-tgf%C3%AE-signaling
#5
L Xia, X Xiao, W L Liu, Y Song, T J J Liu, Y J Li, E Zacksenhaus, X J Hao, Y Ben-David
Coactosin-like protein (CLP, or Cotl1), is an F-actin-binding protein, whose role in cancer is largely unknown. Here we show that CLP/Cotl1 is highly expressed in a rat epithelial breast cancer cell line (FE1.3) compared with its mesenchymal counterpart (FE1.2). Knockdown of CLP/Cotl1 in FE1.3 cells increased cell proliferation, whereas its overexpression in FE1.2 cells inhibited proliferation in culture and reduced tumor growth in xenograft assays in mice. Mechanistically, we identified two major pathways through which CLP/Cotl1 exerts its suppressive effects...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28924365/effects-of-hypobaric-hypoxia-on-rat-retina-and-protective-response-of-resveratrol-to-the-stress
#6
Xiaorong Xin, Hong Dang, Xiaojing Zhao, Haohao Wang
High-altitude retinopathy represents retinal functional changes associated with environmental challenges imposed by hypobaric hypoxia, but the detailed cellular and molecular mechanism underlying this process remains unclear. Our current investigation was to explore the effect of hypobaric hypoxia on the rat retina and determine whether resveratrol has a protective efficacy on the hypoxic damage to the retina. Experiment rats were randomly grouped as the control group, hypoxia group and resveratrol intervention group...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28923650/does-renal-tubular-injury-induced-local-tissue-hypoxia-involve-post-transplantation-erythrocytosis
#7
A Unal, S Ata, C Karakurkcu, M Z Ciraci, I Kocyigit, M H Sipahioglu, B Tokgoz, O Oymak
BACKGROUND: The pathogenesis of post-transplantation erythrocytosis (PTE) is not well understood and appears to be multifactorial. Our hypothesis in this study was that several factors, including toxicity of calcineurin inhibitor, immunologic factors, and chronic allograft nephropathy, can trigger local tissue hypoxia in peritubular interstitium, which is where production of erythropoietin (EPO) takes place. This local interstitial tissue hypoxia can cause an increase in renal EPO production, which induces the development of PTE...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28918043/mir-206-133b-cluster-a-weapon-against-lung-cancer
#8
REVIEW
Jing-Yu Pan, Cheng-Cao Sun, Zhuo-Yue Bi, Zhen-Long Chen, Shu-Jun Li, Qing-Qun Li, Yu-Xuan Wang, Yong-Yi Bi, De-Jia Li
Lung cancer is a deadly disease that ends numerous lives around the world. MicroRNAs (miRNAs) are a group of non-coding RNAs involved in a variety of biological processes, such as cell growth, organ development, and tumorigenesis. The miR-206/133b cluster is located on the human chromosome 6p12.2, which is essential for growth and rebuilding of skeletal muscle. The miR-206/133b cluster has been verified to be dysregulated and plays a crucial role in lung cancer. miR-206 and miR-133b participate in lung tumor cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28912885/brusatol-mediated-inhibition-of-c-myc-increases-hif-1%C3%AE-degradation-and-causes-cell-death-in-colorectal-cancer-under-hypoxia
#9
Eun-Taex Oh, Chan Woo Kim, Ha Gyeong Kim, Jae-Seon Lee, Heon Joo Park
HIF-1 (hypoxia-inducible factor-1) regulates the expression of ~100 genes involved in angiogenesis, metastasis, tumor growth, chemoresistance and radioresistance, underscoring the growing interest in targeting HIF-1 for cancer control. In the present study, we investigated the molecular mechanisms underlying brusatol-induced HIF-1α degradation and cell death in colorectal cancer under hypoxia (0.5% O2). Under hypoxia, pretreatment of cancer cells with brusatol increased HIF-1α degradation and cancer cell death in a dose-dependent manner...
2017: Theranostics
https://www.readbyqxmd.com/read/28912871/paeonol-enhances-the-sensitivity-of-human-ovarian-cancer-cells-to-radiotherapy-induced-apoptosis-due-to-downregulation-of-the-phosphatidylinositol-3-kinase-akt-phosphatase-and-tensin-homolog-pathway-and-inhibition-of-vascular-endothelial-growth-factor
#10
Hai-Mei Zhou, Qin-Xiang Sun, Yan Cheng
Radiotherapy is a vital and effective method to treat solid tumors. However, in many tumor types, development of resistance of cancer cells and cytotoxicity in normal tissues presents a major therapeutic problem. It is therefore crucial to identify and develop novel sensitizing agents that may improve the response to radiation therapy without causing any adverse effects. The present study aimed to investigate whether paeonol, a bioactive flavonoid, was able to confer sensitivity to radiation in human ovarian cancer cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912256/mitochondrial-capacity-oxidative-damage-and-hypoxia-gene-expression-are-associated-with-age-related-division-of-labor-in-honey-bee-apis-mellifera-l-workers
#11
Mário S Cervoni, Carlos A M Cardoso-Júnior, Giovana Craveiro, Anderson de O Souza, Luciane C Alberici, Klaus Hartfelder
During adult life, honeybee workers undergo a succession of behavioral states. Nurses bees perform tasks inside the nest, and when they are about 2-3 weeks old they initiate foraging. This switch is associated with alterations in diet, and with the levels of juvenile hormone and vitellogenin circulating in hemolymph. Less clear is whether this behavioral maturation involves major changes at the cellular level, such as mitochondrial activity and the redox environment in the head, thorax and abdomen. Using high-resolution respirometry, biochemical assays and RT-qPCR, we evaluated the association of these parameters with this behavioral change...
September 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28899657/hif-1%C3%AE-ascl2-mir-200b-regulatory-feedback-circuit-modulated-the-epithelial-mesenchymal-transition-emt-in-colorectal-cancer-cells
#12
Yangyang Shang, Haoyuan Chen, Jun Ye, Xiaolong Wei, Shanxi Liu, Rongquan Wang
We have reported that Achaete scute-like 2 (Ascl2) transcriptionally repressed miR-200 family members and affected the epithelial-mesenchymal transition (EMT)-mesenchymal-epithelial transition (MET) plasticity in colorectal cancer (CRC) cells. However, little is known about the regulation of the Ascl2/miR-200 axis. Here, we found that hypoxia inducible factor-1α (HIF-1α) mRNA levels were positively correlated with Ascl2 mRNA levels and inversely correlated with miR-200b in CRC samples. Mechanistically, we showed that Ascl2 was a downstream target of HIF-1α and had a critical role in the EMT phenotype induced by hypoxia or HIF-1α over-expression...
September 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28894087/hypoxia-inducible-factor-hif-1-promotes-myeloid-derived-suppressor-cells-accumulation-through-entpd2-cd39l1-in-hepatocellular-carcinoma
#13
David Kung-Chun Chiu, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Jane Di Cui, Robin Kit-Ho Lai, Lynna Lan Li, Hui-Yu Koh, Felice Ho-Ching Tsang, Larry Lai Wei, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Myeloid-derived suppressor cells (MDSCs) possess immunosuppressive activities, which allow cancers to escape immune surveillance and become non-responsive to immune checkpoints blockade. Here we report hypoxia as a cause of MDSC accumulation. Using hepatocellular carcinoma (HCC) as a cancer model, we show that hypoxia, through stabilization of hypoxia-inducible factor-1 (HIF-1), induces ectoenzyme, ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2/CD39L1), in cancer cells, causing its overexpression in HCC clinical specimens...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28892580/correlation-of-quantitative-parameters-of-magnetic-resonance-perfusion-weighted-imaging-with-vascular-endothelial-growth-factor-microvessel-density-and-hypoxia-inducible-factor-1%C3%AE-in-nasopharyngeal-carcinoma-evaluation-on-radiosensitivity-study
#14
Ying Hu, Hong E, Xiaoping Yu, Feiping Li, Longwu Zeng, Qiang Lu, Xuping Xi, Liangfang Shen
OBJECTIVES: To investigate the correlation of parameters of magnetic resonance perfusion-weighted imaging (MR-PWI) with the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and microvessel density (MVD) in nasopharyngeal carcinoma (NPC) so as to explore the value of predicting radiosensitivity. DESIGN: A prospective study. SETTING: Department of Head-and-neck radiotherapy in Hunan Cancer Hospital...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28887922/gramine-inhibits-angiogenesis-and-induces-apoptosis-via-modulation-of-tgf-%C3%AE-signalling-in-7-12-dimethylbenz-a-anthracene-dmba-induced-hamster-buccal-pouch-carcinoma
#15
Arunkumar Ramu, Suresh Kathiresan, Bakrudeen Ali Ahmed
BACKGROUND: Transforming growth factor-β (TGF-β) and its receptors are considered as a novel target in cancer chemotherapy. Gramine, an indole alkaloid, possesses various pharmacological properties including antiproliferative and anticancer. However, the anti-angiogenic property remains unexplored. PURPOSE: The present study was designed to evaluate the anti-angiogenic and apoptosis induction properties of gramine through inhibiting TGF-β on DMBA induced oral squamous cell carcinoma (OSCC) in the hamster buccal pouch (HBP)...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28887194/hypoxia-inducible-factor-1%C3%AE-is-involved-in-isoflurane-induced-blood-brain-barrier-disruption-in-aged-rats-model-of-pocd
#16
Yiyun Cao, Zhengqian Li, Hongping Li, Cheng Ni, Lunxu Li, Ning Yang, Chengmei Shi, Yanfeng Zhong, Dehua Cui, Xiangyang Guo
Prolonged exposure to inhaled anesthetics may lead to postoperative cognitive dysfunction (POCD). Nevertheless, the underlying mechanisms are not known. Hypoxia-inducible factor-1α (HIF-1α) and its target gene vascular endothelial growth factor (VEGF) were shown to be activated by inhaled anesthetics. The aim of the present study was to determine the role of HIF-1α in isoflurane-induced blood-brain barrier (BBB) disruption and resultant cognitive impairment. After a 4-h exposure to 1.5% isoflurane in 20-month-old rats, increases in vascular permeability, and disrupted BBB ultrastructure were accompanied by the degradation of tight junction proteins occludin and collagen type IV in brain blood vessels...
September 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28886098/molecular-and-biochemical-responses-of-hypoxia-exposure-in-atlantic-croaker-collected-from-hypoxic-regions-in-the-northern-gulf-of-mexico
#17
Md Saydur Rahman, Peter Thomas
A major impact of global climate change has been the marked increase worldwide in the incidence of coastal hypoxia (dissolved oxygen, DO<2.0 mg l-1). However, the extent of hypoxia exposure to motile animals such as fish collected from hypoxic waters as well as their molecular and physiological responses to environmental hypoxia exposure are largely unknown. A suite of potential hypoxia exposure biomarkers was evaluated in Atlantic croaker collected from hypoxic and normoxic regions in the northern Gulf of Mexico (nGOM), and in croaker after laboratory exposure to hypoxia (DO: 1...
2017: PloS One
https://www.readbyqxmd.com/read/28880966/the-prolyl-4-hydroxylase-inhibitor-gsk360a-decreases-post-stroke-brain-injury-and-sensory-motor-and-cognitive-behavioral-deficits
#18
Jin Zhou, Jie Li, Daniel M Rosenbaum, Jian Zhuang, Carrie Poon, Pu Qin, Katrina Rivera, John Lepore, Robert N Willette, Erding Hu, Frank C Barone
There is interest in pharmacologic preconditioning for end-organ protection by targeting the HIF system. This can be accomplished by inhibition of prolyl 4-hydroxylase (PHD). GSK360A is an orally active PHD inhibitor that has been previously shown to protect the failing heart. We hypothesized that PHD inhibition can also protect the brain from injuries and resulting behavioral deficits that can occur as a result of surgery. Thus, our goal was to investigate the effect of pre-stroke surgery brain protection using a verified GSK360A PHD inhibition paradigm on post-stroke surgery outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28879655/pretreatment-with-fish-oil-attenuates-heart-ischemia-consequences-in-rats
#19
Alcione Lescano de Souza Junior, Jorge Mancini Filho, Rosângela Pavan Torres, Maria Cláudia Irigoyen, Rui Curi
Omega-3 polyunsaturated fatty acid (ω-3 PUFA)-rich fish oil supplementation has protective effects on heart ischemic injury. Left ventricular (LV) ischemia was induced in rats by permanent ligation of the left coronary artery. Saline, fish oil or soybean oil was administered daily by gavage (3 g kg(-1) b.w.) for 20 days before inducing ischemia. Outcomes were assessed 24 hours after left coronary artery ligation. Pretreatment with fish oil decreased the ω-6/ω-3 fatty acid ratio in the LV. Reduction in infarct size and in the intensity of ventricular systolic dysfunction was found in the fish oil group as compared with the saline or soybean oil groups through echocardiographic evaluation...
September 6, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28878873/hypoxia-inducible-factor-hif-as-a-model-for-studying-inhibition-of-protein-protein-interactions
#20
George M Burslem, Hannah F Kyle, Adam Nelson, Thomas A Edwards, Andrew J Wilson
The modulation of protein-protein interactions (PPIs) represents a major challenge in modern chemical biology. Current approaches (e.g. high-throughput screening, computer aided ligand design) are recognised as having limitations in terms of identification of hit matter. Considerable success has been achieved in terms of developing new approaches to PPI modulator discovery using the p53/hDM2 and Bcl-2 family of PPIs. However these important targets in oncology might be considered as "low-hanging-fruit". Hypoxia inducible factor (HIF) is an emerging, but not yet fully validated target for cancer chemotherapy...
June 1, 2017: Chemical Science
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