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https://www.readbyqxmd.com/read/29325025/towards-an-understanding-of-resilience-responding-to-health-systems-shocks
#1
Johanna Hanefeld, Susannah Mayhew, Helena Legido-Quigley, Frederick Martineau, Marina Karanikolos, Karl Blanchet, Marco Liverani, Esther Yei Mokuwa, Gillian McKay, Dina Balabanova
The recent outbreak of Ebola Virus Disease (EVD) in West Africa has drawn attention to the role and responsiveness of health systems in the face of shock. It brought into sharp focus the idea that health systems need not only to be stronger but also more 'resilient'. In this article, we argue that responding to shocks is an important aspect of resilience, examining the health system behaviour in the face of four types of contemporary shocks: the financial crisis in Europe from 2008 onwards; climate change disasters; the EVD outbreak in West Africa 2013-16; and the recent refugee and migration crisis in Europe...
January 9, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29322613/forward-view-advancing-health-library-and-knowledge-services-in-england
#2
Sue Lacey Bryant, Helen Bingham, Ruth Carlyle, Alison Day, Linda Ferguson, David Stewart
This article is the fourth in a series on New Directions. The National Health Service is under pressure, challenged to meet the needs of an ageing population, whilst striving to improve standards and ensure decision making is underpinned by evidence. Health Education England is steering a new course for NHS library and knowledge services in England to ensure access to knowledge and evidence for all decision makers. Knowledge for Healthcare calls for service transformation, role redesign, greater coordination and collaboration...
January 10, 2018: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/29318981/magnesium-homeostasis-in-cattle-absorption-and-excretion
#3
Holger Martens, Sabine Leonhard-Marek, Monika Röntgen, Friederike Stumpff
Magnesium (Mg2+) is an essential mineral without known specific regulatory mechanisms. In ruminants, plasma Mg2+ concentration depends primarily on the balance between Mg2+ absorption and Mg2+ excretion. The primary site of Mg2+ absorption is the rumen, where Mg2+ is apically absorbed by both potential-dependent and potential-independent uptake mechanisms, reflecting involvement of ion channels and electroneutral transporters, respectively. Transport is energised in a secondary active manner by a basolateral Na+/Mg2+ exchanger...
January 10, 2018: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29315979/prevention-of-pressure-ulcers-in-patients-undergoing-sub-acute-rehabilitation-after-severe-brain-injury-an-observational-study
#4
Marianne Brostrup Sachs, Mia Moth Wolffbrandt, Ingrid Poulsen
OBJECTIVE: The aim of this study was to uncover efforts made by healthcare professionals to prevent pressure ulcers (PUs) in patients with severe brain injury undergoing treatment at a sub-acute rehabilitation department. BACKGROUND: PUs is a major burden for patients and also generate considerable healthcare costs. PUs are, nevertheless, prevalent in both secondary and primary care. DESIGN: In this qualitative study, we performed 24-hour observation on four patients undergoing rehabilitation for severe brain injury...
January 9, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29277974/registered-nurse-intent-to-promote-physical-activity-for-hospitalised-liver-transplant-recipients
#5
Jocelyn A Pearson, Kara Mangold, Heidi E Kosiorek, Morgan Montez, Diane M Smith, Brenda J Tyler
AIM: To describe how registered nurse work motivation, attitudes, subjective norm and perceived behavioural control influence intention to promote physical activity in hospitalised adult liver transplant recipients. DESIGN: Descriptive study of clinical registered nurses caring for recipients of liver transplant at a tertiary medical centre. METHODS: Intent to Mobilise Liver Transplant Recipient Scale, Work Extrinsic and Intrinsic Motivation Scale, and demographics were used to explore registered nurses' work motivation, attitudes, subjective norms, perceived behavioural control and intention to promote physical activity of hospitalised adult liver transplant recipients during the acute postoperative phase...
December 26, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/29259820/national-survey-of-ebola-related-knowledge-attitudes-and-practices-before-the-outbreak-peak-in-sierra-leone-august-2014
#6
Mohamed F Jalloh, Paul Sengeh, Roeland Monasch, Mohammad B Jalloh, Nickolas DeLuca, Meredith Dyson, Sheku Golfa, Yukiko Sakurai, Lansana Conteh, Samuel Sesay, Vance Brown, Wenshu Li, Jonathan Mermin, Rebecca Bunnell
Background: The 2014-2015 Ebola epidemic in West Africa was the largest ever to occur. In the early phases, little was known about public knowledge, attitudes and practices (KAP) relating to Ebola virus disease (Ebola). Data were needed to develop evidence-driven strategies to address gaps in knowledge and practice. Methods: In August 2014, we conducted interviews with 1413 randomly selected respondents from 9 out of 14 districts in Sierra Leone using multistage cluster sampling...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29168982/n-terminomics-reveals-control-of-arabidopsis-seed-storage-proteins-and-proteases-by-the-arg-n-end-rule-pathway
#7
Hongtao Zhang, Lucy Gannon, Kirsty L Hassall, Michael J Deery, Daniel J Gibbs, Michael J Holdsworth, Renier A L van der Hoorn, Kathryn S Lilley, Frederica L Theodoulou
The N-end rule pathway of targeted protein degradation is an important regulator of diverse processes in plants but detailed knowledge regarding its influence on the proteome is lacking. To investigate the impact of the Arg/N-end rule pathway on the proteome of etiolated seedlings, we used terminal amine isotopic labelling of substrates with tandem mass tags (TMT-TAILS) for relative quantification of N-terminal peptides in prt6, an Arabidopsis thaliana N-end rule mutant lacking the E3 ligase PROTEOLYSIS6 (PRT6)...
November 23, 2017: New Phytologist
https://www.readbyqxmd.com/read/29163597/morphology-carbohydrate-distribution-gene-expression-and-enzymatic-activities-related-to-cell-wall-hydrolysis-in-four-barley-varieties-during-simulated-malting
#8
Natalie S Betts, Laura G Wilkinson, Shi F Khor, Neil J Shirley, Finn Lok, Birgitte Skadhauge, Rachel A Burton, Geoffrey B Fincher, Helen M Collins
Many biological processes, such as cell wall hydrolysis and the mobilisation of nutrient reserves from the starchy endosperm, require stringent regulation to successfully malt barley (Hordeum vulgare) grain in an industrial context. Much of the accumulated knowledge defining these events has been collected from individual, unrelated experiments, and data have often been extrapolated from Petri dish germination, rather than malting, experiments. Here, we present comprehensive morphological, biochemical, and transcript data from a simulated malt batch of the three elite malting cultivars Admiral, Navigator, and Flagship, and the feed cultivar Keel...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29153924/considerations-to-improve-the-safety-of-cervical-spine-manual-therapy
#9
Nathan Hutting, Roger Kerry, Michel W Coppieters, Gwendolijne G M Scholten-Peeters
Manipulation and mobilisation of the cervical spine are well established interventions in the management of patients with headache and/or neck pain. However, their benefits are accompanied by potential, yet rare risks in terms of serious adverse events, including neurovascular insult to the brain. A recent international framework for risk assessment and management offers directions in the mitigation of this risk by facilitating sound clinical reasoning. The aim of this article is to critically reflect on and summarize the current knowledge about cervical spine manual therapy and to provide guidance for clinical reasoning for cervical spine manual therapy...
November 3, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29018069/using-comprehensive-geriatric-assessment-for-quality-improvements-in-healthcare-of-older-people-in-uk-care-homes-protocol-for-realist-review-within-proactive-healthcare-of-older-people-in-care-homes-peach-study
#10
Maria Zubair, Neil H Chadborn, John R F Gladman, Tom Dening, Adam L Gordon, Claire Goodman
INTRODUCTION: Care home residents are relatively high users of healthcare resources and may have complex needs. Comprehensive geriatric assessment (CGA) may benefit care home residents and improve efficiency of care delivery. This is an approach to care in which there is a thorough multidisciplinary assessment (physical and mental health, functioning and physical and social environments) and a care plan based on this assessment, usually delivered by a multidisciplinary team. The CGA process is known to improve outcomes for community-dwelling older people and those in receipt of hospital care, but less is known about its efficacy in care home residents...
October 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28969642/knowledge-mobilisation-for-policy-development-implementing-systems-approaches-through-participatory-dynamic-simulation-modelling
#11
Louise Freebairn, Lucie Rychetnik, Jo-An Atkinson, Paul Kelly, Geoff McDonnell, Nick Roberts, Christine Whittall, Sally Redman
BACKGROUND: Evidence-based decision-making is an important foundation for health policy and service planning decisions, yet there remain challenges in ensuring that the many forms of available evidence are considered when decisions are being made. Mobilising knowledge for policy and practice is an emergent process, and one that is highly relational, often messy and profoundly context dependent. Systems approaches, such as dynamic simulation modelling can be used to examine both complex health issues and the context in which they are embedded, and to develop decision support tools...
October 2, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28913614/researchers-must-be-aware-of-their-roles-at-the-interface-of-ecosystem-services-science-and-policy
#12
Emilie Crouzat, Isabelle Arpin, Lucas Brunet, Matthew J Colloff, Francis Turkelboom, Sandra Lavorel
Scientists working on ecosystem service (ES) science are engaged in a mission-driven discipline. They can contribute to science-policy interfaces where knowledge is co-produced and used. How scientists engage with the governance arena to mobilise their knowledge remains a matter of personal choice, influenced by individual values. ES science cannot be considered neutral and a discussion of the values that shape it forms an important part of the sustainability dialogue. We propose a simple decision tree to help ES scientists identify their role and the purpose of the knowledge they produce...
September 14, 2017: Ambio
https://www.readbyqxmd.com/read/28833302/patient-experience-with-early-discharge-after-total-knee-arthroplasty-a-focus-group-study
#13
Lise Husby Høvik, Bjørg Aglen, Vigdis Schnell Husby
BACKGROUND: Total knee arthroplasty is experienced as a painful procedure, and pain after surgery seems to be the most limiting factor for early mobilisation. Physical exercise is of utter importance for avoiding complications such as persistent pain and functional limitations. A fast-track pathway aims at improving patient outcome, and patients are now discharged 2-3 days after surgery. Little is known about how the patients cope with pain, exercise or daily activities at home. AIM: To explore the experience of patients undergoing total knee arthroplasty in a fast-track pathway during the first 2 weeks after surgery...
August 23, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28819068/rural-emergency-care-360%C3%A2-mobilising-healthcare-professionals-decision-makers-patients-and-citizens-to-improve-rural-emergency-care-in-the-province-of-quebec-canada-a-qualitative-study-protocol
#14
Richard Fleet, Gilles Dupuis, Jean-Paul Fortin, Jocelyn Gravel, Mathieu Ouimet, Julien Poitras, France Légaré
INTRODUCTION: Emergency departments (EDs) are an important safety net for rural populations. Results of our earlier studies suggest that rural Canadian hospitals have limited access to advanced imaging services and intensive care units and that patients are transferred over large distances. They also revealed significant geographical variations in rural services. In the absence of national standards, our studies raise questions about inequities in rural access to emergency services and the risks for citizens...
August 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28798409/using-blubber-explants-to-investigate-adipose-function-in-grey-seals-glycolytic-lipolytic-and-gene-expression-responses-to-glucose-and-hydrocortisone
#15
Kimberley A Bennett, Kelly J Robinson, Simon E W Moss, Sebastian Millward, Ailsa J Hall
Adipose tissue is fundamental to energy balance, which underpins fitness and survival. Knowledge of adipose regulation in animals that undergo rapid fat deposition and mobilisation aids understanding of their energetic responses to rapid environmental change. Tissue explants can be used to investigate adipose regulation in wildlife species with large fat reserves, when opportunities for organismal experimental work are limited. We investigated glucose removal, lactate, glycerol and NEFA accumulation in media, and metabolic gene expression in blubber explants from wild grey seals...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765051/how-does-calcium-interact-with-the-cytoskeleton-to-regulate-growth-cone-motility-during-axon-pathfinding
#16
REVIEW
Robert J Gasperini, Macarena Pavez, Adrian C Thompson, Camilla B Mitchell, Holly Hardy, Kaylene M Young, John K Chilton, Lisa Foa
The precision with which neurons form connections is crucial for the normal development and function of the nervous system. The development of neuronal circuitry in the nervous system is accomplished by axon pathfinding: a process where growth cones guide axons through the embryonic environment to connect with their appropriate synaptic partners to form functional circuits. Despite intense efforts over many years to understand how this process is regulated, the complete repertoire of molecular mechanisms that govern the growth cone cytoskeleton and hence motility, remain unresolved...
July 29, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28759580/knowledge-attitudes-and-practices-towards-yaws-and-yaws-like-skin-disease-in-ghana
#17
Michael Marks, Cynthia Kwakye-Maclean, Rachel Doherty, Paul Adwere, Abdul Aziz Abdulai, Fredrick Duah, Sally-Ann Ohene, Oriol Mitja, Blanche Oguti, Anthony W Solomon, David C W Mabey, Yaw Adu-Sarkodie, Kingsley Asiedu, Mercy M Ackumey
INTRODUCTION: Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appropriate community mobilisation. An understanding of community knowledge, attitudes and practices related to yaws in Ghana and other endemic countries will be vital in designing effective community engagement strategies...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28743548/identifying-barriers-to-early-mobilisation-among-mechanically-ventilated-patients-in-a-trauma-intensive-care-unit
#18
Kari Johnson, Jamie Petti, Amy Olson, Tina Custer
Mechanically ventilated patients can be at risk for functional decline (Cameron et al., 2015). Early mobilisation of mechanically ventilated patients can improve outcomes after critical illness to prevent this decline. Although registered nurses understand the importance of early mobilisation there are nurses who are unwilling to mobilise patients. AIM: The aim of this study is to examine whether nurses' attitudes and beliefs are barriers for early mobilisation and evaluate whether an education intervention can improve early mobilisation...
October 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28722774/-promoting-continuity-of-care-specialist-nurses-role-experiences-in-gynaecological-oncology-a-qualitative-study
#19
Andrea Kobleder, Hanna Mayer, Larissa Gehrig, Beate Senn
AIMS AND OBJECTIVES: To investigate the experiences of specialist nurses in Switzerland concerning their role of caring for women with gynaecological cancer. BACKGROUND: Women with gynaecological cancer often face complex situations, which require an integrative and quality-assured approach by the healthcare system. Specialist nurses can play an important role in supporting these patients. However, in countries where the role of specialist nurses is at a developmental stage, their role lacks clarity...
July 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28721199/evidence-informed-capacity-building-for-setting-health-priorities-in-low-and-middle-income-countries-a-framework-and-recommendations-for-further-research
#20
Ryan Li, Francis Ruiz, Anthony J Culyer, Kalipso Chalkidou, Karen J Hofman
Priority-setting in health is risky and challenging, particularly in resource-constrained settings. It is not simply a narrow technical exercise, and involves the mobilisation of a wide range of capacities among stakeholders - not only the technical capacity to "do" research in economic evaluations. Using the Individuals, Nodes, Networks and Environment (INNE) framework, we identify those stakeholders, whose capacity needs will vary along the evidence-to-policy continuum. Policymakers and healthcare managers require the capacity to commission and use relevant evidence (including evidence of clinical and cost-effectiveness, and of social values); academics need to understand and respond to decision-makers' needs to produce relevant research...
2017: F1000Research
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