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https://www.readbyqxmd.com/read/28426760/regulation-of-proteinaceous-effector-expression-in-phytopathogenic-fungi
#1
REVIEW
Kar-Chun Tan, Richard P Oliver
Effectors are molecules used by microbial pathogens to facilitate infection via effector-triggered susceptibility or tissue necrosis in their host. Much research has been focussed on the identification and elucidating the function of fungal effectors during plant pathogenesis. By comparison, knowledge of how phytopathogenic fungi regulate the expression of effector genes has been lagging. Several recent studies have illustrated the role of various transcription factors, chromosome-based control, effector epistasis, and mobilisation of endosomes within the fungal hyphae in regulating effector expression and virulence on the host plant...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28414783/acceptability-and-feasibility-of-early-infant-male-circumcision-for-hiv-prevention-in-malawi
#2
Charles Chilimampunga, Simeon Lijenje, Judith Sherman, Kelvin Nindi, Webster Mavhu
BACKGROUND: Voluntary medical male circumcision (VMMC) has been successfully implemented in 14 countries as an additional HIV prevention intervention. As VMMC programs mature in most countries, the focus is now on how to sustain the HIV prevention gains realised from VMMC. As part of preparations for the sustainability phase, countries are either piloting or preparing to pilot early infant male circumcision (EIMC). This qualitative study explored the acceptability and feasibility of EIMC in Malawi in order to inform pilot implementation...
2017: PloS One
https://www.readbyqxmd.com/read/28388937/advancing-engagement-methods-for-trials-the-core-study-relational-model-of-engagement-for-a-stepped-wedge-cluster-randomised-controlled-trial-of-experience-based-co-design-for-people-living-with-severe-mental-illnesses
#3
Lauralie Richard, Donella Piper, Wayne Weavell, Rosemary Callander, Rick Iedema, John Furler, David Pierce, Kali Godbee, Jane Gunn, Victoria J Palmer
BACKGROUND: Engagement is essential in trials research but is rarely embedded across all stages of the research continuum. The development, use, effectiveness and value of engagement in trials research is poorly researched and understood, and models of engagement are rarely informed by theory. This article describes an innovative methodological approach for the development and application of a relational model of engagement in a stepped wedge designed cluster randomised controlled trial (RCT), the CORE study...
April 8, 2017: Trials
https://www.readbyqxmd.com/read/28387658/do-turkish-patients-with-lumbar-disc-herniation-know-body-mechanics
#4
Sacide Yildizeli Topcu
BACKGROUND AND OBJECTIVE: Most common and important cause of the low back pain is lumbar disc herniation. Patients with lumbar disc herniation face with difficulties during daily activities due to the reduction of physical functions. In order to maintain daily activities without pain and discomfort, the patients should be informed about proper positions and body mechanics. The aim of the study was to determine the knowledge and the applications of the patients with lumbar disc herniation about body mechanics...
March 31, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28372742/an-optimised-sequential-extraction-scheme-for-the-evaluation-of-vanadium-mobility-in-soils
#5
Yu-Hui Xu, Jen-How Huang, Helmut Brandl
Reviewing the current state of knowledge about sequential extraction applied for soil vanadium (V) fractionation, we identified an urgent requirement of an sequential extraction (SE) specified for V. Namely, almost all previous SE extracted only 8.4%-48% of total V in soils (excluding residue). Thus, we proposed an eight-step SE for V fractionation in soils according to the knowledge gained from literature and our own dissolution experiments with model minerals. After extracting the mobilisable and adsorbed V with de-ionised water and 5mmol/L phosphate, 1mol/L pyrophosphate was applied to gather organic matter bound V which minimised the artefact dissolving Al and Fe (hydr)oxides occurred when using HNO3-H2O2 for extraction...
March 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28190550/overcoming-nursing-barriers-to-intensive-care-unit-early-mobilisation-a-quality-improvement-project
#6
Oluwatobi O Hunter, Elisabeth L George, Dianxu Ren, Douglas Morgan, Margaret Rosenzweig, Patricia Klinefelter Tuite
OBJECTIVES: To increase adherence with intensive care unit mobility by developing and implementing a mobility training program that addresses nursing barriers to early mobilisation. DESIGN: An intensive care unit mobility training program was developed, implemented and evaluated with a pre-test, immediate post-test and eight-week post-test. Patient mobility was tracked before and after training. SETTING: A ten bed cardiac intensive care unit...
February 9, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28136021/prevention-diagnosis-and-treatment-of-venous-thromboembolism
#7
Richard Greenall
Venous thromboembolism (VTE) occurs more frequently in older people. For those nursing older people in a variety of settings, knowledge of VTE prevention, diagnosis and treatment is essential. This article discusses simple, practical measures that can be used to reduce the risk of VTE, including good hydration and promotion of mobilisation. It also discusses how a VTE forms, the signs and symptoms, and the methods used to diagnose and treat VTE. In recent years new drugs have been licensed to treat patients with VTE called direct oral anticoagulants...
January 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28135864/-naloxone-works-the-politics-of-knowledge-in-evidence-based-drug-policy
#8
Kari Lancaster, Carla Treloar, Alison Ritter
For over 20 years, drug policy experts have been calling for the wider availability of naloxone, to enable lay overdose witnesses to respond to opioid overdose events. However, the 'evidence base' for peer-administered naloxone has become a key point of contention. This contention opens up critical questions about how knowledge ('evidence') is constituted and validated in drug policy processes, which voices may be heard, and how knowledge producers secure privileged positions of influence. Taking the debate surrounding peer-administered naloxone as a case study, and drawing on qualitative interviews with individuals (n = 19) involved in the development of naloxone policy in Australia, we examine how particular kinds of knowledge are rendered 'useful' in drug policy debates...
January 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28073542/the-rise-of-toxic-benthic-phormidium-proliferations-a-review-of-their-taxonomy-distribution-toxin-content-and-factors-regulating-prevalence-and-increased-severity
#9
REVIEW
Tara G McAllister, Susanna A Wood, Ian Hawes
There has been a marked increase in the distribution, intensity and frequency of proliferations of some species of the benthic mat-forming, toxin-producing genus Phormidium in rivers globally over the last decade. This review summarises current knowledge on their taxonomy, distribution, toxin content, environmental drivers of proliferations, and monitoring and management strategies in New Zealand. Although toxic Phormidium proliferation occurs in rivers worldwide little is known about these factors in most countries...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28063656/effect-of-cyclic-redox-oscillations-on-water-quality-in-freshwater-acid-sulfate-soil-wetlands
#10
Niloofar Karimian, Scott G Johnston, Edward D Burton
Restoration of acid sulfate soil (ASS) wetlands by freshwater re-flooding can lead to the reformation of various Fe(II) and reduced inorganic sulfur (RIS) species in surface soil layers. However, in many locations, wetland water levels undergo large seasonal fluctuations that drive extreme redox oscillations. Newly formed RIS species [e.g. greigite, mackinawite, nano-pyrite and S(0)] and Fe(II) are vulnerable to rapid oxidation during dry periods and may generate substantial acidity. Rainfall following a dry period may then mobilise acidity and metal cations in surface waters prior to eventual recovery in pH by re-establishment of reducing conditions...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28039127/effectiveness-of-early-compared-with-conservative-rehabilitation-for-patients-having-rotator-cuff-repair-surgery-an-overview-of-systematic-reviews
#11
Bruno Fles Mazuquin, Andrew Charles Wright, Sarah Russell, Puneet Monga, James Selfe, Jim Richards
AIM/OBJECTIVE: The aim is to critically analyse and discuss the current literature and determine the effectiveness of rehabilitation for patients after surgical repair of rotator cuff tears for range of motion (ROM), pain, functional status and retear rates; in addition, an update of new literature is included. DESIGN: Overview of systematic reviews. DATA SOURCES: A search was performed with no restrictions to date of publication and language in the following databases: EBSCO, AMED, CINAHL, SPORTDiscus, EMBASE, Cochrane, LILACS, MEDLINE, PEDro, Scielo, SCOPUS and Web of Knowledge...
December 30, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28034556/who-falls-in-an-adult-emergency-department-and-why-a-retrospective-review
#12
Deanne R McErlean, James A Hughes
INTRODUCTION: Falls are a significant source of healthcare related morbidity and mortality of patients in hospitals and residential healthcare settings. Commonly falls are thought of as an affliction of the elderly and the frail. The emergency department (ED) is a unique healthcare setting that sees patients in the acute and hyper acute stages of physical and mental illness and intoxication. Falls occur in this setting, however there is little knowledge about the factors that influence falls in the emergency department...
February 2017: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/27993166/the-effect-of-community-groups-and-mobile-phone-messages-on-the-prevention-and-control-of-diabetes-in-rural-bangladesh-study-protocol-for-a-three-arm-cluster-randomised-controlled-trial
#13
Edward Fottrell, Hannah Jennings, Abdul Kuddus, Naveed Ahmed, Joanna Morrison, Kohenour Akter, Sanjit Kumar Shaha, Badrun Nahar, Tasmin Nahar, Hassan Haghparast-Bidgoli, A K Azad Khan, Anthony Costello, Kishwar Azad
BACKGROUND: Increasing rates of type 2 diabetes mellitus place a substantial burden on health care services, communities, families and individuals living with the disease or at risk of developing it. Estimates of the combined prevalence of intermediate hyperglycaemia and diabetes in Bangladesh vary, and can be as high as 30% of the adult population. Despite such high prevalence, awareness and control of diabetes and its risk factors are limited. Prevention and control of diabetes and its complications demand increased awareness and action of individuals and communities, with positive influences on behaviours and lifestyle choices...
December 19, 2016: Trials
https://www.readbyqxmd.com/read/27993138/scaling-up-complex-interventions-insights-from-a-realist-synthesis
#14
REVIEW
Cameron D Willis, Barbara L Riley, Lisa Stockton, Aneta Abramowicz, Dana Zummach, Geoff Wong, Kerry L Robinson, Allan Best
Preventing chronic diseases, such as cancer, cardiovascular disease and diabetes, requires complex interventions, involving multi-component and multi-level efforts that are tailored to the contexts in which they are delivered. Despite an increasing number of complex interventions in public health, many fail to be 'scaled up'. This study aimed to increase understanding of how and under what conditions complex public health interventions may be scaled up to benefit more people and populations.A realist synthesis was conducted and discussed at an in-person workshop involving practitioners responsible for scaling up activities...
December 19, 2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/27936423/optimising-the-community-based-approach-to-healthcare-improvement-comparative-case-studies-of-the-clinical-community-model-in-practice
#15
Emma-Louise Aveling, Graham Martin, Georgia Herbert, Natalie Armstrong
Community-based approaches to healthcare improvement are receiving increasing attention. Such approaches could offer an infrastructure for efficient knowledge-sharing and a potent means of influencing behaviours, but their potential is yet to be optimised. After briefly reviewing challenges to community-based approaches, we describe in detail the clinical community model. Through exploring clinical communities in practice, we seek to identify practical lessons for optimising this community-based approach to healthcare improvement...
January 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/27909582/ebola-research-funding-a-systematic-analysis-1997-2015
#16
Joseph Ra Fitchett, Amos Lichtman, Damilola T Soyode, Ariel Low, Jimena Villar de Onis, Michael G Head, Rifat Atun
BACKGROUND: The latest outbreak of Ebola in West Africa overwhelmed the affected countries, with the impact on health extending far beyond Ebola-related deaths that have exceeded 11 000. The need to promptly mobilise resources to control emerging infections is widely recognized. Yet, data on research funding for emerging infections remains inadequately documented. METHODS: We defined research investment as all funding flows for Ebola and/or Marburg virus from 1997 to April 2015 whose primary purpose was to advance knowledge and new technologies to prevent or cure disease...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27756414/implementation-context-and-complexity
#17
Carl R May, Mark Johnson, Tracy Finch
BACKGROUND: Context is a problem in research on health behaviour change, knowledge translation, practice implementation and health improvement. This is because many intervention and evaluation designs seek to eliminate contextual confounders, when these represent the normal conditions into which interventions must be integrated if they are to be workable in practice. DISCUSSION: We present an ecological model of the ways that participants in implementation and health improvement processes interact with contexts...
October 19, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27716415/an-evidence-synthesis-of-the-international-knowledge-base-for-new-care-models-to-inform-and-mobilise-knowledge-for-multispecialty-community-providers-mcps
#18
Alison Turner, Abeda Mulla, Andrew Booth, Shiona Aldridge, Sharon Stevens, Fraser Battye, Peter Spilsbury
BACKGROUND: NHS England's Five Year Forward View (NHS England, Five Year Forward View, 2014) formally introduced a strategy for new models of care driven by simultaneous pressures to contain costs, improve care and deliver services closer to home through integrated models. This synthesis focuses on a multispecialty community provider (MCP) model. This new model of care seeks to overcome the limitations in current models of care, often based around single condition-focused pathways, in contrast to patient-focused delivery (Royal College of General Practitioners, The 2022 GP: compendium of evidence, 2012) which offers greater continuity of care in recognition of complex needs and multimorbidity...
October 1, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27681150/psychosocial-well-being-of-people-living-with-hiv-and-the-community-before-and-after-a-hiv-stigma-reduction-community-hub-network-intervention
#19
Catharina D Prinsloo, Minrie Greeff, Annamarie Kruger, Suria Ellis
The purpose of the research was to determine whether an HIV stigma-reduction community "hub" network intervention in a South African urban area would bring about a difference in the psychosocial well-being of people living with HIV (PLWH), as well as their community (living in the same municipal ward). A single case pre-test post-test design was implemented. The sample for this study included 62 PLWH who were selected through accessibility sampling and 570 community members who were selected through random voluntary sampling...
September 2016: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/27634655/knowledge-attitudes-and-practices-towards-blood-donation-in-barbados
#20
A E Atherley, C G Taylor, A Whittington, C Jonker
OBJECTIVE: To obtain information to devise strategies for a voluntary blood donor mobilisation campaign in Barbados. BACKGROUND: The World Health Organization (WHO) recommends that 100% blood should be collected from voluntary non-remunerated donors (VNRD), yet the majority of blood donations (75%) in Barbados are family/replacement donations. Increasing VNRD is paramount to achieving a safe, reliable blood supply, and understanding the population is a strategy suggested by the WHO to inform donor recruitment and education...
December 2016: Transfusion Medicine
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