Read by QxMD icon Read

Blood brainbarrier

Juan Córdoba, Rafael Esteban Mur
Hepatic encephalopathy (EH) is a severe complication of hepatic cirrhosis that is characterized by multiple neuropsychiatric manifestations. EH is usually triggered by a precipitating factor and occurs in patients with severely impaired hepatic function. Minimal EH is characterized by minor cognitive impairments that are difficult to specify but represent a risk for the patients. The primary pathophysiological mechanism of EH is considered to be an increase in blood ammonia with an impairment in the patency of the blood-brainbarrier and its metabolism to glutamine in astrocytes...
July 2014: Gastroenterología y Hepatología
Nobuaki Ohtake, Mieko Saito, Masaaki Eto, Kenjiro Seki
Glucagon-like peptide-1 (GLP-1) is a novel treatment modality for type 2 diabetes mellitus. However, GLP-1 has been suggested as a therapeutic target for Alzheimer's disease (AD). In rodent studies, GLP-1 reduces amyloid beta (Aβ) and facilitates synaptic plasticity. Therefore, in the present study, we investigated how GLP-1 facilitates synaptic plasticity and reduces the Aβ in vivo. Exendin-4, a GLP-1 receptor agonist that can cross the blood brain barrier, was subcutaneously administered to adult mice. We then extracted the total and the plasma membrane proteins from the mouse neocortex...
May 2014: Regulatory Peptides
Elizabeth Fox, David Amaral, Judy Van de Water
Recent evidence has emerged indicating that the maternal immune response can have a substantial deleterious impact on prenatal development (Croen et al., [2008]: Biol Psychiatry 64:583-588). The maternal immune response is largely sequestered from the fetus. Maternal antibodies, specifically immunoglobulin G (IgG), are passed to the fetus to provide passive immunity throughout much of pregnancy. However, both protective and pathogenic autoantibodies have equal access to the fetus (Goines and Van de Water [2010]: Curr Opin Neurol 23:111-117)...
October 2012: Developmental Neurobiology
Eleonora Tavazzi, Lorenzo Minoli, Pasquale Ferrante, Paola Scagnelli, Serena Del Bue, Alfredo Romani, Sabrina Ravaglia, Enrico Marchioni
OBJECTIVE: To describe clinical, MRI and cerebrospinal fluid (CSF) features of a varicella zoster virus (VZV) related meningo-encephalo-myelitis (MEM) without rash in an immunocompetent female. PATIENT: An 85 year old immunocompetent woman with mild hyperthermia and acute, severe MEM. INTERVENTION: Serum antibodies and CSF PCR were searched for several viruses. Brain and spinal cord MRI were performed. Immunological profile. TREATMENTS: i...
September 2008: Neurological Sciences
V A Otellin, D E Korzhevskiĭ
Using the methods of light and electron microscopy and immunocytochemistry, the barrier structures on the outer surface of the forming human brain were studied in the early prenatal period of development. The data obtained suggest that the superficial barrier in the forming brain is heteromorphous and consists of differently specialized morpho-functional complexes. The areas of contact of developing brain surface with blood capillaries of pericerebral vascular network were found to be the zone of the blood-brainbarrier formation, while the areas of the surface bordering the meningeal extracellular matrix were the zone of future liquor-brain barrier...
2002: Morfologi︠a︡
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"