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https://www.readbyqxmd.com/read/29792224/health-technology-assessment-of-public-health-interventions-an-analysis-of-characteristics-and-comparison-of-methods-study-protocol
#1
Tim Mathes, Gerald Willms, Stephanie Polus, Constance Stegbauer, Melanie Messer, Corinna Klingler, Heidi Ehrenreich, Dea Niebuhr, Georg Marckmann, Ansgar Gerhardus, Dawid Pieper
BACKGROUND: Conducting a health technology assessment (HTA) of public health interventions (PHIs) poses some challenges. PHIs are often complex interventions, which affect the number and degree of interactions of the aspects to be assessed. Randomized controlled trials on PHIs are rare as they are difficult to conduct because of ethical or feasibility issues. The aim of this study is to provide an overview of the methodological characteristics and to compare the applied assessment methods in HTAs on PHIs...
May 23, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29792193/research-ethics-review-at-university-eduardo-mondlane-uem-maputo-central-hospital-mozambique-2013-2016-a-descriptive-analysis-of-the-start-up-of-a-new-research-ethics-committee-rec
#2
Jahit Sacarlal, Vasco Muchanga, Carlos Mabutana, Matilde Mabui, Arlete Mariamo, Assa Júlio Cuamba, Leida Artur Fumo, Jacinta Silveira, Elizabeth Heitman, Troy D Moon
BACKGROUND: Mozambique has seen remarkable growth in biomedical research over the last decade. To meet a growing need, the National Committee for Bioethics in Health of Mozambique (CNBS) encouraged the development of ethical review processes at institutions that regularly conduct medical and social science research. In 2012, the Faculty of Medicine (FM) of University Eduardo Mondlane (UEM) and the Maputo Central Hospital (MCH) established a joint Institutional Committee on Bioethics for Health (CIBS FM & MCH)...
May 23, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29792078/ethical-values-of-academic-nurses-a-pilot-study
#3
Yıldız Denat, Yurdanur Dikmen, Gülşah Gürol Arslan
BACKGROUND: While academics contribute to the development of society through all the subjects that they work on, they also have other important tasks to fulfill, such as being role models for their students and society. Therefore, the place of academic ethical values is a significant topic for academic nurses. OBJECTIVE: The main objective of this research was to examine the attitudes of academic nurses toward academic ethics. RESEARCH DESIGN: This descriptive and cross-sectional research study was conducted between March and June 2017 in three different public universities in Turkey...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29791943/the-growing-reality-of-the-neurological-complications-of-global-stem-cell-tourism
#4
Katie Julian, Nick Yuhasz, Ethan Hollingsworth, Jaime Imitola
"Stem cell tourism" is defined as the unethical practice of offering unproven cellular preparations to patients suffering from various medical conditions. This phenomenon is rising in the field of neurology as patients are requesting information and opportunities for treatment with stem cells for incurable conditions such as multiple sclerosis and amyotrophic lateral sclerosis, despite their clinical research and experimental designation. Here, we review the recent trends in "stem cell tourism" in both the United States and abroad, and discuss the recent reports of neurological complications from these activities...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791917/hybrid-diffuse-reflectance-spectroscopy-non-erythemal-in-vivo-testing-of-sun-protection-factor
#5
Mathias Rohr, Nikolai Ernst, Andreas Schrader
BACKGROUND/AIMS: In order to define a label sun protection factor (SPF) of topically applied sunscreens, in vivo test methods like ISO 24444, FDA guideline, or the Australian standard are used worldwide. The basis of all these methods is provoking an erythemal skin reaction by UV irradiation to find the level of unprotected and protected minimal erythemal doses (MED). In vitro methods replacing the human skin by any kind of non-human material are still not available. Thus, offering the new hybrid diffuse reflectance spectroscopy (HDRS) technique that is able to stay on an in vivo level for SPF testing but meanwhile neglecting the UV-dose-related erythemal skin reaction is a perfect combination to take care of sun protection and any ethical concerns in SPF testing nowadays...
May 23, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29791762/ethical-dilemmas-in-nursing-an-integrative-review
#6
REVIEW
Jennifer Rainer, Joanne Kraenzle Schneider, Rebecca A Lorenz
AIMS: The purpose of this integrative review was to identify themes and gaps in the literature to stimulate researchers to develop strategies to guide decision-making among clinical nurses faced with ethical dilemmas. BACKGROUND: The concept of ethical dilemmas has been well explored in nursing because of the frequency of ethical dilemmas in practice and the toll these dilemmas can take on nurses. Although ethical dilemmas are prevalent in nursing practice, frequently leading to moral distress, there is little guidance in the literature to help nurses resolve them...
May 23, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29791757/organ-donation-after-euthanasia-morally-acceptable-under-strict-procedural-safeguards
#7
Gert van Dijk, Rozemarijn van Bruchem-Visser, Inez de Beaufort
In this paper, we will present a case of organ donation after active euthanasia (ODE) in The Netherlands from a patient who had his life ended at his explicit and voluntary request. The form of ODE we describe here concerns patients who are not unconscious and on life support, but who are conscious and want to have their life ended because of their hopeless and unbearable suffering, for instance due to a terminal illness such as Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS). This form of ODE is of course only possible in jurisdictions where euthanasia is allowed...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29791673/development-of-a-clinical-protocol-for-detection-of-cervical-cancer-precursor-lesions
#8
Deise Maria Do Nascimento Sousa, Ana Carolina Maria Araújo Chagas, Camila Teixeira Moreira Vasconcelos, Airton Tetelbom Stein, Mônica Oliveira Batista Oriá
OBJECTIVE: to develop and validate the content of a clinical protocol aimed at prevention of cervical cancer in primary care. METHOD: technological research according to the steps: (1) submission of the project to the research ethics committee; (2) bibliographic survey; (3) elaboration of the clinical protocol; and (4) content validation. In the third step, the information was collected through bibliographic research and gynecology specialists were consulted. For the final step, four judges were selected to evaluate the clinical protocol according to AGREE 2...
2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29791671/validation-of-a-moral-distress-instrument-in-nurses-of-primary-health-care
#9
Priscila Orlandi Barth, Flávia Regina Souza Ramos, Edison Luiz Devos Barlem, Graziele de Lima Dalmolin, Dulcinéia Ghizoni Schneider
OBJECTIVE: to validate an instrument to identify situations that trigger moral distress in relation to intensity and frequency in primary health care nurses. METHOD: this is a methodological study carried out with 391 nurses of primary health care, applied to the Brazilian Scale of Moral Distress in Nurses with 57 questions. Validation for primary health care was performed through expert committee evaluation, pre-test, factorial analysis, and Cronbach's alpha. RESULTS: there were 46 questions validated divided into six constructs: Health Policies, Working Conditions, Nurse Autonomy, Professional ethics, Disrespect to patient autonomy and Work Overload...
2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29791623/social-representation-of-elderly-people-on-falls-structural-analysis-and-in-the-light-of-neuman
#10
Jéssica de Castro Santos, Cristina Arreguy-Sena, Paulo Ferreira Pinto, Elenir de Paiva Pereira, Marcelo da Silva Alves, Fabiano Bolpato Loures
OBJECTIVE: To understand the symbolic elements and the hierarchical system of representations of elderly people on falls, according to Abric's structural analysis and Neuman's theory. METHOD: Abric structural approach developed at the home of primary care users in a city of Minas Gerais. A free evocation technique of images triggered by images was performed in 2016 with elderly individuals (≥65 years old). Data treated by dictionary of equivalent terms; processed in Evoc 2000 software converging, analytically, according to Neuman...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791466/understanding-health-advocacy-in-family-medicine-and-psychiatry-curricula-and-practice-a-qualitative-study
#11
Sophie Soklaridis, Carrie Bernard, Genevieve Ferguson, Lisa Andermann, Mark Fefergrad, Kenneth Fung, Karl Iglar, Andrew Johnson, Morag Paton, Cynthia Whitehead
BACKGROUND: We explored understanding and experiences of health advocacy among psychiatry and family medicine residents and faculty and the implications for clinical care and teaching through the lens of relationship-centred care. METHODS: This qualitative study was conducted in the psychiatry and family medicine departments at a large urban university. We interviewed 19 faculty members and conducted two focus groups with 18 residents. Semi-structured questions explored the relational meaning of health advocacy, how residents and faculty learned about the role and ethical considerations involved in incorporating advocacy work into clinical practice within a relationship-centred care framework...
2018: PloS One
https://www.readbyqxmd.com/read/29791310/ways-of-knowing-as-a-framework-for-developing-reflective-practice-among-nursing-students
#12
T Diane Campbell, Kelly Penz, Marie Dietrich-Leurer, Karen Juckes, Kathy Rodger
Abstract Background:Nursing students face the challenge of developing a comprehensive understanding of the complex role of the registered nurse across various clinical settings. Frameworks such as the "ways of knowing", help students conceptualize and critically reflect upon important processes in their professional learning. However, the academic language used to describe frameworks can be challenging. PURPOSE: This manuscript has two purposes. First, to briefly describe the historical climate influencing the development of nursing as a discipline...
May 23, 2018: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/29791213/nurses-perspectives-on-pharmacology-why-what-and-at-which-point-of-the-curricula-should-education-be-delivered
#13
Ehsan U Khan, Pauline A Hood
AIMS AND OBJECTIVES: the study aimed to capture the views of nursing students and qualified nurses about pharmacology education and at which point the subject should be taught. BACKGROUND: drug errors are common in clinical practice. However, the presence of pharmacology education in nursing curricula varies, with few higher education institutes focusing on the topic in pre-registration years. DESIGN: a cross-sectional survey was carried out with 46 pre-registration, 18 post-qualification and 15 post-qualification nurse prescribing course students...
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29791170/effectiveness-and-safety-of-lixisenatide-for-treatment-of-diabetes-in-the-real-world-data-from-the-monitoring-registry-in-a-real-life-cohort-in-the-czech-and-slovak-republic
#14
Martin Haluzík, Alena Adamíková, Milan Běhunčík, Marek Macko, Radka Štěpánová
INTRODUCTION: GLP1 receptor agonist lixisenatide has demonstrated its efficacy in numerous clinical trials, nevertheless its real-life effectiveness data is limited. AIM: To describe effectiveness and safety of lixisenatide in routine clinical practice in the Czech Republic and the Slovak Republic, as recorded by the Registry-Based Observational Study. METHODS: Multinational, multicenter, observational, non-interventional, 6-month prospective product registry of patients with type 2 diabetes mellitus aged > 18 years who were initiating therapy with lixisenatide...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791017/addressing-the-vexed-issue-of-authorship-and-author-order-a-discussion-paper
#15
Terence V McCann, Meg Polacsek
AIMS: To review and discuss authorship and author order in the context of nursing and midwifery publications and to present a set of principles to guide and justify author order. BACKGROUND: Variation in author order trends is evident across different authors, disciplines and countries. Confusion and conflict between authors give rise to important issues concerning ethics and collaboration and may delay publication. Lack of transparency in authorship practices also impedes judgements when individual contributions are used in support of employment, promotion, tenure and/or research funding applications...
May 23, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29790357/-control-editing-of-the-genome-within-reach-or-already-in-our-hands
#16
Radim Brdička, Radoslav Omelka
Although different genome editing tools have been around for decades, the recent emergence of cheap, quick, and accessible CRISPR/Cas9 technology has led to a revolution in this field. The technique has the potential to transform medicine from curative into preventive using a gene therapy. An application of genome editing has proven to be effective for both genetic and non-genetic (e.g. infectious) diseases. However, cancer and rare diseases treatment is at the forefront of interest. Concurrently, the legal and ethical frameworks should be discussed, especially as the technology moves towards a modification of the germ cells or embryos...
2018: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29790139/-the-process-of-healing-child-physical-abuse-sprouting-and-twining
#17
Hsin-Yi Chang, Jui-Ying Feng, Ren-Mei Tseng
BACKGROUND: Child physical abuse impacts the physical and psychological health of survivors. Healing child abuse is an essential process that helps survivors reorganize the meaning of the trauma and pursue a normal life. Considering the trauma of child physical abuse within the social context allows the experiences of individual survivors to be reflected in their process of healing. PURPOSE: To explore the social interaction and construction process of healing experienced by survivors of child physical abuse...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789954/genetics-of-movement-disorders-and-the-practicing-clinician-who-and-what-to-test-for
#18
REVIEW
Alessio Di Fonzo, Edoardo Monfrini, Roberto Erro
PURPOSE OF REVIEW: This review aims to provide the basic knowledge on the genetics of hypokinetic and hyperkinetic movement disorders to guide clinicians in the decision of "who and what to test for?" RECENT FINDINGS: In recent years, the identification of various genetic causes of hypokinetic and hyperkinetic movement disorders has had a great impact on a better definition of different clinical syndromes. Indeed, the advent of next-generation sequencing (NGS) techniques has provided an impressive step forward in the easy identification of genetic forms...
May 23, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29789905/pre-operative-mri-staging-of-endometrial-cancer-in-a-multicentre-cancer-network-can-we-match-single-centre-study-results
#19
N D Soneji, N Bharwani, A Ferri, V Stewart, A Rockall
OBJECTIVES: To evaluate the staging accuracy of magnetic resonance imaging (MRI) for endometrial cancer in daily practice over a 3-year period at a tertiary referral centre receiving scans from a large number of hospitals with varying protocols. To compare these daily practice results to published data from single-centre studies. METHODS: After ethical approval, MRI staging records for 270 studies from nine network and three centre hospitals were retrospectively collected and compared with final operative histopathology...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29789351/development-and-validation-of-two-clinical-prediction-models-to-inform-clinical-decision-making-for-lumbar-spinal-fusion-surgery-for-degenerative-disorders-and-rehabilitation-following-surgery-protocol-for-a-prospective-observational-study
#20
Alison B Rushton, Martin L Verra, Andrew Emms, Nicola R Heneghan, Deborah Falla, Michael Reddington, Ashley A Cole, Paul Willems, Lorin Benneker, David Selvey, Michael Hutton, Martijn W Heymans, J Bart Staal
INTRODUCTION: Potential predictors of poor outcome will be measured at baseline: (1) preoperatively to develop a clinical prediction model to predict which patients are likely to have favourable outcome following lumbar spinal fusion surgery (LSFS) and (2) postoperatively to predict which patients are likely to have favourable long-term outcomes (to inform rehabilitation). METHODS AND ANALYSIS: Prospective observational study with a defined episode inception of the point of surgery...
May 22, 2018: BMJ Open
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