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https://www.readbyqxmd.com/read/29155436/enzyme-replacement-therapy-for-infantile-onset-pompe-disease
#1
REVIEW
Min Chen, Lingli Zhang, Shuyan Quan
BACKGROUND: Infantile-onset Pompe disease is a rare and progressive autosomal-recessive disorder caused by a deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). Current treatment involves enzyme replacement therapy (with recombinant human alglucosidase alfa) and symptomatic therapies (e.g. to control secretions). Children who are cross-reactive immunological material (CRIM)-negative require immunomodulation prior to commencing enzyme replacement therapy.Enzyme replacement therapy was developed as the most promising therapeutic approach for Pompe disease; however, the evidence is lacking, especially regarding the optimal dose and dose frequency...
November 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29155117/pediatric-non-missile-penetrating-head-injury-case-series-and-literature-review
#2
REVIEW
Evangelos Drosos, Dimitrios Giakoumettis, Alexandros Blionas, Andreas Mitsios, Georgios Sfakianos, Marios Themistocleous
BACKGROUND: Pediatric non-missile penetrating head injury (NMPHI) is usually accidental attributed mainly to the softer skulls of growing children. However, it is a rather rare entity and therefore no consensus exists regarding treatment, in order to effectively prevent the immediate and long-term complications. Throughout the literature practice, essentials are mostly discussed in case reviews and case series in general population. No data originating from randomized studies are available due to ethical and practical limitations...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29154886/personality-and-attitudinal-correlates-of-meat-consumption-results-of-two-representative-german-samples
#3
Tamara M Pfeiler, Boris Egloff
The vast amount of meat consumed in the Western world is critically discussed with regard to negative health consequences, environmental impact, and ethical concerns for animals, emphasizing the need to extend knowledge regarding the correlates of meat consumption in the general population. In the present article, we conducted two studies examining the associations between meat consumption and personality traits, political attitudes, and environmental attitudes in two large German representative samples (Ntotal = 8,879, aged 18-96 years)...
November 14, 2017: Appetite
https://www.readbyqxmd.com/read/29154849/spinal-anesthesia-is-associated-with-lower-recurrence-rates-after-resection-of-non-muscle-invasive-bladder-cancer
#4
Yuri Koumpan, Melanie Jaeger, Glenio Bitencourt Mizubuti, Rob Tanzola, Kunal Jain, Gregory Hosier, Wilma Hopman, D Robert Siemens
PURPOSE: To determine if anesthetic type (general vs. spinal) would influence cancer recurrence following transurethral resections of bladder tumors. MATERIALS & METHODS: With institutional ethics board approval, electronic medical records of all patients who underwent a transurethral bladder tumor resection for non-muscle invasive urothelial bladder cancer between 2011-2013 at a single tertiary care centre were examined. Follow-up information was gathered for all patients in December 2016...
November 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29154476/valuing-our-communities-ethical-considerations-for-economic-evaluation-of-community-based-prevention
#5
Max Crowley, Damon Jones
Restricted public budgets and increasing efforts to link the impact of community interventions to public savings have increased the use of economic evaluation. While this type of evaluation can be important for program planning, it also raises important ethical issues about how we value the time of local stakeholders who support community interventions. In particular, researchers navigate issues of scientific accuracy, institutional inequality, and research utility in their pursuit of even basic cost estimates...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154468/fight-flight-or-remain-silent-juggling-multiple-accountabilities-throughout-the-formative-stage-of-a-neighborhood-revitalization-initiative
#6
Stacey M Kesten, Deborah A Perez, Denise S Marques, Scot D Evans, Adrienne Sulma
This paper describes the experiences of a research team as they navigated uncertain ethical and political terrain throughout the formative stage of a public housing redevelopment project. Specifically, we discuss the challenges related to balancing multiple accountabilities and the tensions among the various roles and responsibilities that emanated from different accountabilities. Due to contractual obligations to our funding source, established relations with community partners, and an ethical imperative to align with those holding the least power, we grappled with embodying multiple and often conflicting roles...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154409/sensitive-topics-missing-data-and-refusal-in-social-network-studies-an-ethical-examination
#7
Erin Rose Ellison, Regina Day Langhout
We describe our ethics-driven process of addressing missing data within a social network study about accountability for racism, classism, sexism, heterosexism, cis-sexism, ableism, and other forms of oppression among social justice union organizers. During data collection, some would-be participants did not return emails and others explicitly refused to engage in the research. All refusals came from women of color. We faced an ethical dilemma: Should we continue to seek participation from those who had not yet responded, with the hopes of recruiting more women of color from within the network so their perspectives would not be tokenized? Or, should we stop asking those who had been contacted multiple times, which would compromise the social network data and analysis? We delineate ways in which current discussions of the ethics of social network studies fell short, given our framework and our community psychology (CP) values...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154399/for-the-good-of-the-group-balancing-individual-and-collective-risks-and-benefits-in-community-psychology-research
#8
Emily R Dworkin, Nicole E Allen
Balancing risks and benefits is a necessary ethical task for social science researchers. Community psychologists must often consider risks and benefits not just for individual participants, but also for the group, system, or society that those individuals inhabit. Little ethical guidance currently exists for how to navigate this ethical challenge across these multiple levels. In this article, we use a case example of social network research incorporating multiple levels of analysis to identify common risks and benefits and understand their relationship to each other...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154398/community-data-collection-with-children-of-mothers-living-with-hiv-boundaries-of-the-researcher-role
#9
Rebecca Hill LeCroix, Nada M Goodrum, Schell Hufstetler, Lisa P Armistead
The TRACK-II program is a multi-site, community-based randomized controlled trial evaluating an intervention to assist mothers living with HIV (MLH) in disclosing their HIV status to their young children. Many participants-both mothers and children-reported significant depression and/or suicidal ideation, a phenomenon that presented ethical challenges. This article focuses on participants at one site (Atlanta). Through the vignette of "Jordan," we describe ethical challenges that may arise when faced with the responsibility of maximizing participants' safety while maintaining the boundaries of the researcher role...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154396/nurses-experiences-of-unprofessional-behaviors-in-the-emergency-department-a-qualitative-study
#10
Naser Parizad, Hadi Hassankhani, Azad Rahmani, Eesa Mohammadi, Violeta Lopez, Michelle Cleary
The nursing profession is focused on serving others and has high expectations that each member behaves professionally and ethically, as articulated in nursing codes of practice and conduct. Where these are not upheld, inappropriate and unprofessional workplace behaviors follow. Regrettably, unprofessional behavior is neither new nor constrained to the nursing profession, but is known to negatively impact staff and workplace relationships, and importantly, patient safety and care. The aim of this qualitative study was to explore Iranian nurses' experiences of professional communication between colleagues in the emergency department...
November 20, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29154159/turning-wounds-into-wisdom-posttraumatic-growth-over-the-course-of-two-types-of-trauma-focused-psychotherapy-in-patients-with-ptsd
#11
Mirjam J Nijdam, Christianne A I van der Meer, Mirjam van Zuiden, Pasha Dashtgard, Daniël Medema, Yulan Qing, Paul Zhutovsky, Anne Bakker, Miranda Olff
BACKGROUND: Treatment studies in PTSD patients have mostly focused on adverse psychopathological outcomes whereas positive outcomes have received less attention. Objectives of this study were to investigate posttraumatic growth in response to two different psychotherapies, to examine the relationship between symptom improvement and growth, and to determine if posttraumatic growth predicted treatment response. METHODS: Outpatients diagnosed with PTSD after various types of trauma (n = 116) participated in a randomized controlled trial that compared Brief Eclectic Psychotherapy for PTSD (BEP) and Eye Movement Desensitization and Reprocessing therapy (EMDR)...
November 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29153455/could-we-remedy-the-crisis-of-care-by-incorporating-mandatory-group-psychotherapy-in-nurse-education
#12
EDITORIAL
Suzanne Bliss
This paper suggests a tentative proposal for nurse education that may go some way to remedying the 'crisis of care' described by Judge Francis and others. Any viable strategy to improve caring attitudes in nursing students must involve activities across the curriculum that foster self-awareness and empathy. It is suggested that the best way to do this is for all undergraduate nursing students to participate in regular, supervised group psychotherapy sessions as a mandated requirement for registration. This strategy would be helpful in at least two main ways...
November 13, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29153410/balancing-ethics-and-care-in-disorders-of-consciousness
#13
Laura Y Cabrera, Judy Illes
No abstract text is available yet for this article.
November 15, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29153353/-something-humane-has-been-lost-re-evaluation-of-the-attitudes-of-senior-physicians-towards-the-g-drg-system-a-qualitative-normative-analysis
#14
Marco Knoll, Ina Otte, Sabine Salloch, Caroline Ruiner, Esta Kruppa, Jochen Vollmann
Only a few years after the implementation of the G-DRG (German Diagnosis Related Group) system physicians already began to complain of its negative effects on the quality of inpatient healthcare. The present study examines the recent experiences senior physicians have made with regard to the impact of the G-DRG system on the quality of healthcare and medical professionalism. Nine qualitative guided expert interviews were conducted focusing on the experiences of physicians in leading positions dealing with the G-DRG system in their everyday work...
November 15, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29153336/-genetics-and-family-medicine
#15
R Bugarín-González, Á Carracedo
There have been spectacular advances in genetics in the last decades. Their implications in medicine have been so relevant that the family doctor cannot ignore them. However, interestingly, our specialty training program has hardly any contents related to this discipline. For this reason, several publications have warned of the need to correct this deficit and to determine the knowledge, skills and abilities in genetics that should be acquired by family physicians. It is considered that, in addition to some general concepts, we must have training related to genetic testing, genetic counselling, aspects related to hereditary cancers, and to be aware of the ethical and legal limits of genetic information...
November 16, 2017: Semergen
https://www.readbyqxmd.com/read/29153012/conflict-between-nursing-student-s-personal-beliefs-and-professional-nursing-values
#16
David Pickles, Sheryl de Lacey, Lindy King
BACKGROUND: Studies have established that negative perceptions of people living with HIV/AIDS exist among nursing students throughout the world, perceptions which can be detrimental to the delivery of high-quality nursing care. OBJECTIVES: The purpose of this research was to explore socio-cultural influences on the perceptions of nursing students towards caring for people living with HIV/AIDS. RESEARCH DESIGN: The study was guided by stigma theory, a qualitative descriptive research approach was adopted...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/29152594/-blaming-shaming-humiliation-stigmatising-medical-interactions-among-people-with-non-epileptic-seizures
#17
Catherine Robson, Olaug S Lian
Background: People with non-epileptic seizures (NES) describe challenging relationships with health professionals, and explain negative interactions as common and expected. Despite these difficulties, little is known about how people with NES experience difficult healthcare encounters. Methods: Using a thematic discourse analysis approach, we analysed the free-text survey responses of 135 people with NES and asked: what kind of challenges do people living with this condition encounter when interacting with health professionals, and how do they experience the consequences of difficult interactions? We explore their experiences by interpreting the latent meaning of participants' texts from a social-constructionist perspective on health and illness...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29152515/should-copyright-be-transferred-before-a-manuscript-is-accepted
#18
Jaime A Teixeira da Silva
Academic journals that undergo a process of academic scrutiny often pass a stage of peer review and subsequent editorial approval. In a process that can take weeks or months (in some cases, even years), an author aims to satisfy the requirements of peer reviewer and editorial scrutiny that would merit publication of their work. It is customary to, in traditional, non-open access journals, to then sign over copyright to the publisher, upon which the publisher then issues a proof, and the manuscript is then published...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29151697/anatomic-isolated-caudate-lobectomy-is-it-possible-to-establish-a-standard-surgical-flow
#19
Yun Jin, Liang Wang, Yuan-Quan Yu, Dong-Er Zhou, Da-Ren Liu, Jun-Jie Yang, Shu-You Peng, Jiang-Tao Li
AIM: To establish the surgical flow for anatomic isolated caudate lobe resection. METHODS: The study was approved by the ethics committee of the Second Affiliated Hospital Zhejiang University School of Medicine (SAHZU). From April 2004 to July 2014, 20 patients were enrolled who underwent anatomic isolated caudate lobectomy at SAHZU. Clinical and postoperative pathological data were analyzed. RESULTS: Of the total 20 cases, 4 received isolated complete caudate lobectomy (20%) and 16 received isolated partial caudate lobectomy (80%)...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29151496/cost-effectiveness-analysis-of-cardiovascular-disease-treatment-in-japan
#20
Satoshi Kodera, Arihiro Kiyosue, Jiro Ando, Hiroshi Akazawa, Hiroyuki Morita, Masafumi Watanabe, Issei Komuro
The quality-adjusted life year (QALY) and incremental cost-effectiveness ratio (ICER) are important concepts in cost-effectiveness analysis, which is becoming increasingly important in Japan. QALY is used to estimate quality of life (QOL) and life years, and can be used to compare the efficacies of cancer and cardiovascular treatments. ICER is defined as the difference in cost between treatments divided by the difference in their effects, with a smaller ICER indicating better cost-effectiveness. Here, we present a review of cost-effectiveness analyses in Japan as well other countries...
November 17, 2017: International Heart Journal
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