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https://www.readbyqxmd.com/read/29334611/understanding-complex-tribofilms-by-means-of-h3bo3-b2o3-model-glasses
#1
Fabiana Spadaro, Antonella Rossi, Shivaprakash N Ramakrishna, Emmanuel Lainé, Philip Woodward, Nicholas D Spencer
The discovery of the spontaneous reaction of boric oxides with moisture in the air to form lubricious H3BO3 films has led to great interest in the tribology of boron compounds in general. Despite this, a study of the growth kinetics of H3BO3 on a B2O3 substrate under controlled relative humidity (RH), has not yet been reported in the literature. Here, we describe the tribological properties of H3BO3-B2O3 glass systems after aging under controlled relative humidity over different lengths of time. A series of tribological tests has been performed applying a normal load of 15 N, at both room temperature and 100°C in Yubase 4 oil...
January 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29334554/the-systemic-immune-inflammation-index-independently-predicts-survival-and-recurrence-in-resectable-pancreatic-cancer-and-its-prognostic-value-depends-on-bilirubin-levels-a-retrospective-multicenter-cohort-study
#2
Mohammad Hosein Aziz, Kostandinos Sideras, Nasir Ahmad Aziz, Katya Mauff, Roel Haen, Daphne Roos, Lawlaw Saida, Mustafa Suker, Erwin van der Harst, Jan Sven Mieog, Bert A Bonsing, Yarne Klaver, Bas Groot Koerkamp, Casper H van Eijck
OBJECTIVE: Our aim was to determine the prognostic significance of the systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as the primary outcome. BACKGROUND: Pancreatic cancer is associated with a dysfunctional immune system and poor prognosis. We examined the prognostic significance of the SIII in patients with resectable pancreatic ductal adenocarcinoma (PDAC) and the effects of bilirubin on this index...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29334380/light-activated-chemical-probing-of-nucleobase-solvent-accessibility-inside-cells
#3
Chao Feng, Dalen Chan, Jojo Joseph, Mikko Muuronen, William H Coldren, Nan Dai, Ivan R Corrêa, Filipp Furche, Christopher M Hadad, Robert C Spitale
The discovery of functional RNAs that are critical for normal and disease physiology continues to expand at a breakneck pace. Many RNA functions are controlled by the formation of specific structures, and an understanding of each structural component is necessary to elucidate its function. Measuring solvent accessibility intracellularly with experimental ease is an unmet need in the field. Here, we present a novel method for probing nucleobase solvent accessibility, Light Activated Structural Examination of RNA (LASER)...
January 15, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29334372/pharmacological-blockade-of-asct2-dependent-glutamine-transport-leads-to-antitumor-efficacy-in-preclinical-models
#4
Michael L Schulte, Allie Fu, Ping Zhao, Jun Li, Ling Geng, Shannon T Smith, Jumpei Kondo, Robert J Coffey, Marc O Johnson, Jeffrey C Rathmell, Joe T Sharick, Melissa C Skala, Jarrod A Smith, Jordan Berlin, M Kay Washington, Michael L Nickels, H Charles Manning
The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer metabolism has led to surprisingly few new drugs to date. The neutral amino acid glutamine serves as a key intermediate in numerous metabolic processes leveraged by cancer cells, including biosynthesis, cell signaling, and oxidative protection. Herein we report the preclinical development of V-9302, a competitive small molecule antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2...
January 15, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29334293/dna-barcoding-for-species-identification-in-deep-sea-clams-mollusca-bivalvia-vesicomyidae
#5
Jun Liu, Haibin Zhang
Deep-sea clams (Bivalvia: Vesicomyidae) have been found in reduced environments over the world oceans, but taxonomy of this group remains confusing at species and supraspecific levels due to their high-morphological similarity and plasticity. In the present study, we collected mitochondrial COI sequences to evaluate the utility of DNA barcoding on identifying vesicomyid species. COI dataset identified 56 well-supported putative species/operational taxonomic units (OTUs), approximately covering half of the extant vesicomyid species...
January 15, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29334243/facile-synthesis-of-simple-2-oxindole-based-compounds-with-promising-antiproliferative-activity
#6
Riham F George
AIM: Discovery of novel potent anticancer agents with lower side effects is a challenge to overcome cancer, the second leading cause of death. METHODOLOGY: 2-oxindole-based hydrazides (6a-g) and benzenesulfonyl hydrazides (9a-d) were synthesized by simple condensation reactions of the appropriate hydrazides (2a-g) or (8a-d) with 1-ethyl-2,3-oxindolinedione (4). They were screened for their cytotoxicity against HepG2 (liver), MCF-7 (breast), HCT116 (colon) and A549 (lung) cancer cell lines...
January 15, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29334241/transcriptional-regulation-on-the-gene-expression-signature-in-combined-allergic-rhinitis-and-asthma-syndrome
#7
Zhengdao Mao, Yujia Shi, Qi Cao, Yi Chen, Yun Sun, Zhiguang Liu, Qian Zhang, Mao Huang
AIM: This study was intended to evaluate transcriptional regulation of gene expression signatures in combined allergic rhinitis and asthma syndrome (CARAS). MATERIALS & METHODS: The blood samples of three patients with CARAS, three patients with allergic rhinitis and three normal controls were obtained. The cuffdiff, miRDeep2 and DEGseq were used to quantify the expression of genes and miRNAs, respectively. And p-value < 0.01 and false discovery rate < 0...
January 15, 2018: Epigenomics
https://www.readbyqxmd.com/read/29333857/active-site-revealed-for-water-oxidation-on-electrochemically-induced-%C3%AE-mno2-role-of-spinel-to-layer-phase-transition
#8
Yefei Li, Zhi-Pan Liu
Seeking for active MnOx material as artificial water splitting catalyst has been a long history since the discovery of PSII system in Nature. To date, the highest activity MnOx catalyst reported for oxygen evolution reaction (OER) is however not common MnO2 polymorphs (α-, β-, δ-MnO2), but nascent δ-MnO2 layer produced in situ from spinel under electrochemical conditions with unknown active site structure. Here with the stochastic surface walking (SSW) pathway sampling method, we for the first time resolve the atomic-level mechanism of spinel-to-layer Mn3O4 solid phase transition in aqueous electrolyte...
January 15, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29333788/enhancement-of-standard-ecgs-by-a-new-method-for-multi-cycle-superimposition-and-summation
#9
Aharon Frimerman, Simcha Meisel, Avraham Shotan, David S Blondheim
BACKGROUND: Since the introduction of the electrocardiogram (ECG) in 1902, the fundamentals of ECG data acquisition, display, and interpretation in the clinical arena have not changed much. OBJECTIVES: To present a new method to enhance and improve acquisition, analysis, and display of the standard ECG. METHODS: We performed ECG enhancement by superimposition and summation of multiple standard ECG cycles of each lead, by temporal alignment to peak R wave and voltage alignment to an improved baseline, at the T-P segment...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29333729/immunoengineering-with-biomaterials-for-enhanced-cancer-immunotherapy
#10
REVIEW
Yu-Qing Xie, Lixia Wei, Li Tang
Cancer immunotherapy has recently shown dramatic clinical success inducing durable response in patients of a wide variety of malignancies. Further improvement of the clinical outcome with immune related cancer treatment requests more exquisite manipulation of a patient's immune system with increased immunity against diseases while mitigating the toxicities. To meet this challenge, biomaterials applied to immunoengineering are being developed to achieve tissue- and/or cell-specific immunomodulation and thus could potentially enhance both the efficacy and safety of current cancer immunotherapies...
January 14, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29333638/rapid-profiling-of-polymeric-phenolic-acids-in-salvia-miltiorrhiza-by-hybrid-data-dependent-targeted-multistage-mass-spectrometry-acquisition-based-on-expected-compounds-prediction-and-fragment-ion-searching
#11
Yao Shen, Zijin Feng, Min Yang, Zhe Zhou, Sumei Han, Jinjun Hou, Zhenwei Li, Wanying Wu, De-An Guo
Phenolic acids are the major water-soluble components in Salvia miltiorrhiza (> 5%). According to previous studies, many of them contribute to the cardiovascular effects and antioxidant effects of S. miltiorrhiza. Polymeric phenolic acids can be considered as the tanshinol derived metabolites, e.g., dimmers, trimers and tetramers. A strategy combined with tanshinol-based expected compounds prediction, total ion chromatogram filtering, Fragment Ion Searching and parent list-based multistage mass spectrometry acquisition by Linear Trap Quadropole-orbitrap Velos Mass Spectrometry was proposed to rapid profile polymeric phenolic acids in S...
January 15, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29333491/multifunctional-bioreactor-system-for-human-intestine-tissues
#12
Wenda Zhou, Ying Chen, Terrence Roh, Yinan Lin, Shengjie Ling, Siwei Zhao, James D Lin, Noor Khalil, Dana M Cairns, Eleana Manousiouthakis, Megan Tse, David L Kaplan
The three-dimensional (3D) cultivation of intestinal cells and tissues in dynamic bioreactor systems to represent in vivo intestinal microenvironments is essential for developing regenerative medicine treatments for intestinal diseases. We have previously developed in vitro human intestinal tissue systems using a 3D porous silk scaffold system with intestinal architectures and topographical features for the adhesion, growth, and differentiation of intestinal cells under static culture conditions. In this study, we designed and fabricated a multifunctional bioreactor system that incorporates pre-epithelialized 3D silk scaffolds in a dynamic culture environment for in vitro engineering of human intestine tissues...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29333481/theta-sequences-of-grid-cell-populations-can-provide-a-movement-direction-signal
#13
Ipshita Zutshi, Jill K Leutgeb, Stefan Leutgeb
It has been proposed that path integration in mammals is performed by the convergence of internally generated speed and directional inputs onto grid cells. Although this hypothesis has been supported by the discovery that head direction, speed, and grid cells are intermixed within entorhinal cortex and by the recent finding that head-direction inputs are necessary for grid firing, many details on how grid cells are generated have remained elusive. For example, analysis of recording data suggests that substituting head direction for movement direction accrues errors that preclude the formation of grid patterns...
October 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/29333345/ontogeny-reversal-and-phylogenetic-analysis-of-turritopsis-sp-5-cnidaria-hydrozoa-oceaniidae-a-possible-new-species-endemic-to-xiamen-china
#14
Jun-Yuan Li, Dong-Hui Guo, Peng-Cheng Wu, Li-Sheng He
Ontogeny reversal, as seen in some cnidarians, is an unprecedented phenomenon in the animal kingdom involving reversal of the ordinary life cycle. Three species of Turritopsis have been shown to be capable of inverted metamorphosis, a process in which the pelagic medusa transforms back into a juvenile benthic polyp stage when faced with adverse conditions. Turritopsis sp.5 is a species of Turritopsis collected from Xiamen, China which presents a similar ability, being able to reverse its life cycle if injured by mechanical stress...
2018: PeerJ
https://www.readbyqxmd.com/read/29333268/progress-of-genome-wide-association-studies-of-ankylosing-spondylitis
#15
REVIEW
Zhixiu Li, Matthew A Brown
Ankylosing spondylitis (AS) is an immune-mediated arthritis which primarily affects the spine and sacroiliac joints. Significant progress has been made in discovery of genetic associations with AS by genome-wide association studies (GWAS) over past decade. These findings have uncovered novel pathways involved pathogenesis of the disease and have led to introduction of novel therapeutic treatments for AS. In this Review, we discuss the genetic variations associated with AS identified by GWAS, the major pathways revealed by these AS-associated variations and critical cell types involved in AS development...
December 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29333058/acquisition-of-a-socially-learned-tool-use-sequence-in-chimpanzees-implications-for-cumulative-culture
#16
Gillian L Vale, Sarah J Davis, Susan P Lambeth, Steven J Schapiro, Andrew Whiten
Cumulative culture underpins humanity's enormous success as a species. Claims that other animals are incapable of cultural ratcheting are prevalent, but are founded on just a handful of empirical studies. Whether cumulative culture is unique to humans thus remains a controversial and understudied question that has far-reaching implications for our understanding of the evolution of this phenomenon. We investigated whether one of human's two closest living primate relatives, chimpanzees, are capable of a degree of cultural ratcheting by exposing captive populations to a novel juice extraction task...
September 2017: Evolution and Human Behavior: Official Journal of the Human Behavior and Evolution Society
https://www.readbyqxmd.com/read/29332841/improved-neuron-culture-using-scaffolds-made-of-three-dimensional-pdms-micro-lattices
#17
Sisi Li, Francesco Paolo Ulloa Severino, Jelena Ban, Li Wang, Giulietta Pinato, Vincent Torre, Yong Chen
Tissue engineering strives to create functional components of organs with different cell types in vitro. One of the challenges is to fabricate scaffolds for three-dimensional (3D) cell culture under physiological conditions. Of particular interesting is to investigate the morphology and function of the central nervous system (CNS) cultured using such scaffolds. Here, we used an elastomer, polydimethylsiloxane (PDMS), to produce lattice-type scaffolds from a photolithography defined template. The photomask with antidot arrays was spin-coated by a thick layer of resist and downward mounted on a rotating stage at angle of 45°...
January 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29332706/skin-mapping-for-the-classification-of-generalized-morphea
#18
Noelle Teske, Joseph Welser, Heidi Jacobe
BACKGROUND: Generalized morphea lacks cohesive clinical features, limiting its clinical and investigative utility. OBJECTIVE: We sought to use computerized lesion mapping to objectively subtype morphea. METHODS: We conducted a 2-part cross-sectional study. In part 1, we created a discovery cohort of patients with generalized morphea of whom lesion maps were created to characterize subsets. Clinical and demographic features were compared between proposed subsets to determine if they identified clinically relevant differences...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29332662/a-survivorship-study-of-838-total-elbow-replacements-a-report-from-the-norwegian-arthroplasty-register-1994-2016
#19
Yngvar Krukhaug, Geir Hallan, Eva Dybvik, Stein A Lie, Ove N Furnes
BACKGROUND: The aim of this study was to present the long-term survivorship (20 years) of total elbow arthroplasty (TEA) for a relatively large population and to compare different prosthesis brands and patient subgroups. METHODS: Between 1994 and 2017, a total of 838 primary TEAs were reported to the Norwegian Arthroplasty Register. Implant survival was calculated using the Kaplan-Meier method. Risk differences were examined using Cox regression analyses and exact Cox regression for rare events...
February 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29332642/current-affairs-future-perspectives-of-tuberculosis-and-antitubercular-agents
#20
REVIEW
Jineetkumar Gawad, Chandrakant Bonde
Tuberculosis (TB) is the major threat for humans from past several decades. Even after advent of several antitubercular drugs, researchers are still struggling for the mycobacterial infections in humans are TB and leprosy. Chronic infections caused by Mycobacterium tuberculosis and Mycobacterium leprae. A particular problem with both of these organisms is that they can survive inside macrophages after phagocytosis, unless these cells are activated by cytokines produced by T-lymphocytes, because of this researchers are not yet succeeded in finding effective treatment on TB...
January 2018: Indian Journal of Tuberculosis
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