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https://www.readbyqxmd.com/read/28918225/on-the-relationship-between-executive-functions-of-working-memory-and-components-derived-from-fluid-intelligence-measures
#1
Xuezhu Ren, Karl Schweizer, Tengfei Wang, Pei Chu, Qin Gong
The aim of the current study is to provide new insights into the relationship between executive functions and intelligence measures in considering the item-position effect observed in intelligence items. Raven's Advanced Progressive Matrices (APM) and Horn's LPS reasoning test were used to assess fluid intelligence which served as criterion in investigating the relationship between intelligence and executive functions. A battery of six experimental tasks measured the updating, shifting, and inhibition processes of executive functions...
September 14, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#2
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28915672/an-updated-meta-analysis-of-amantadine-for-treating-dyskinesia-in-parkinson-s-disease
#3
Min Kong, Maowen Ba, Chao Ren, Ling Yu, Shengjie Dong, Guoping Yu, Hui Liang
In recent years, a few of randomized controlled trials (RCTs) about amantadine for treating dyskinesia in Parkinson's disease (PD) were completed. Here, we conducted a systematic literature review about the clinical research to provide the updated evidence for treating dyskinesia. Electronic search of Medline, PubMed, Cochrane Library, and other databases up to May 2016 for relevant studies was performed. We selected the Unified Parkinson's Disease Rating Scale IV (UPDRS IV) and Dyskinesia Rating Scales (DRS) as efficacy outcomes of amantadine on dyskinesia...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914448/significant-burden-of-nonalcoholic-fatty-liver-disease-with-advanced-fibrosis-in-the-us-a-cross-sectional-analysis-of-2011-2014-national-health-and-nutrition-examination-survey
#4
R J Wong, B Liu, T Bhuket
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in the US. Understanding the epidemiology of NAFLD, with specific focus on individuals with hepatic fibrosis is important to guide healthcare resource planning. AIM: To evaluate prevalence and predictors of hepatic fibrosis among US adults with NAFLD. METHODS: We performed a cross-sectional study using data from the updated 2011-2014 National Health and Nutrition Examination Survey, a national, stratified, multistage sampling survey of non-institutionalised US adults age ≥ 20...
September 15, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28914194/diabetic-retinopathy-recent-updates-on-different-biomarkers-and-some-therapeutic-agents
#5
Amjad Ali Khan, Arshad Husain Rahmani, Yousef Homood Aldebasi
BACKGROUND: Diabetic Retinopathy is a leading cause of sight-threatening complication, which occurs due to a number of physiological and metabolic abnormalities during later stages of diabetes. Many of these abnormal changes are consistent with altered oxidative stress, inflammation, genetic set up, advanced glycation end products, and hematological changes. So the altered levels of different biomolecules related to these changes serve as important biomarkers to assess better evaluation and early treatment of this disease...
September 15, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28912179/classification-epidemiology-and-global-burden-of-cardiomyopathies
#6
REVIEW
William J McKenna, Barry J Maron, Gaetano Thiene
In the past 25 years, major advances were achieved in the nosography of cardiomyopathies, influencing the definition and taxonomy of this important chapter of cardiovascular disease. Nearly, 50% of patients dying suddenly in childhood or adolescence or undergoing cardiac transplantation are affected by cardiomyopathies. Novel cardiomyopathies have been discovered (arrhythmogenic, restrictive, and noncompacted) and added to update the World Health Organization classification. Myocarditis has also been named inflammatory cardiomyopathy...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28911342/efficacy-and-safety-of-transcatheter-arterial-chemoembolization-and-transcatheter-arterial-chemotherapy-infusion-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#7
Xinyang Liu, Zhichao Wang, Zongwei Chen, Longzi Liu, Lijie Ma, Liangqing Dong, Zhao Zhang, Shu Zhang, Liuxiao Yang, Jieyi Shi, Jia Fan, Xiaoying Wang, Qiang Gao
Hepatocellular carcinoma (HCC) is a worldwide health threat with increasing incidence and high mortality rate. Most HCCpatients are diagnosed at an advanced stage, and are unable to undergo potential curative surgery. Transcatheter arterial chemoembolization (TACE) and transcatheter arterial chemotherapy infusion (TACI) are two main palliative treatments for advanced HCC patients. The clinical efficacy and safety of TACE and TACI are controversial. For this reason, we conducted the current systematic review and meta-analysis to summarize current evidence...
September 14, 2017: Oncology Research
https://www.readbyqxmd.com/read/28906159/advances-in-nano-delivery-systems-for-doxorubicin-an-updated-insight
#8
Ummarah Kanwal, Nadeem Irfan Bukhari, Muhammad Ovais, Nasir Abass, Khalid Hussain, Abida Raza
Doxorubicin (DOX) is the most effective chemotherapeutic drug developed against broad range of cancers such as solid tumors, transplantable leukemias and lymphomas. Conventional DOX induced cardiotoxicity has limited its use. FDA approved drugs i.e. non-pegylated liposomal (Myocet®) and pegylated liposomal (Doxil®) formulations have no doubt shown comparatively reduced cardiotoxicity, but has raised new toxicity issues. The entrapment of doxorubicin in biocompatible, biodegradable and safe nano delivery systems can prevent its degradation in circulation minimizing its toxicity with increased half life, enhanced pharmacokinetic profile leading to improved patient compliance...
September 14, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28905423/who-standards-for-biotherapeutics-including-biosimilars-an-example-of-the-evaluation-of-complex-biological-products
#9
REVIEW
Ivana Knezevic, Elwyn Griffiths
The most advanced regulatory processes for complex biological products have been put in place in many countries to provide appropriate regulatory oversight of biotherapeutic products in general, and similar biotherapeutics in particular. This process is still ongoing and requires regular updates to national regulatory requirements in line with scientific developments and up-to-date standards. For this purpose, strong knowledge of and expertise in evaluating biotherapeutics in general and similar biotherapeutic products, also called biosimilars, in particular is essential...
September 14, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28903995/ros1-1
#10
REVIEW
Prodipto Pal, Zanobia Khan
ROS1 is a receptor tyrosine kinase that has recently been shown to undergo gene rearrangements in~1%-2% of non-small cell lung carcinoma (NSCLC) and in a variety of other tumours including cholangiocarcinoma, gastric carcinoma, colorectal carcinoma and in spitzoid neoplasms, glioblastoma and inflammatory myofibroblastic tumours. The ROS1 gene fusion undergoes constitutive activation, regulates cellular proliferation and is implicated in carcinogenesis. ROS1 fusions can be detected by fluorescence in situ hybridisation, real-time PCR, sequencing-based techniques and immunohistochemistry-based methods in clinical laboratories...
September 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28901970/the-2016-who-classification-of-central-nervous-system-tumors-what-neurologists-need-to-know
#11
John C DeWitt, Andreas Mock, David N Louis
PURPOSE OF REVIEW: The 2016 WHO classification of tumors of the central nervous system (2016 CNS WHO) features many changes that are relevant to neurologists treating patients with brain tumors as well as neurologists involved in basic, clinical, and epidemiological research. This review summarizes what neurologists need to know and will need to know in the next years. RECENT FINDINGS: The 2016 CNS WHO introduces diagnostic terms that 'integrate' histological and molecular information and suggests presenting diagnoses in a four-layered reporting format...
September 9, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28901965/anaplastic-gliomas-in-adults-an-update
#12
Cristina Izquierdo, Bastien Joubert, François Ducray
PURPOSE OF REVIEW: The current review summarizes recent advances on the oncogenesis, classification and treatment of adult anaplastic gliomas. RECENT FINDINGS: According to the 2016 WHO classification, three main molecular subgroups of adult diffuse anaplastic gliomas can be distinguished based on the 1p/19q codeletion and isocitrate dehydrogenase (IDH) mutation status. In the future, this classification may be further refined based on the telomerase reverse transcriptase promoter and alpha thalassemia/mental retardation syndrome X-linked mutation status, gene expression, DNA methylation and genomic profiling...
September 8, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28901021/optimisation-of-chemotherapy-and-radiotherapy-for-untreated-hodgkin-lymphoma-patients-with-respect-to-second-malignant-neoplasms-overall-and-progression-free-survival-individual-participant-data-analysis
#13
REVIEW
Jeremy Franklin, Dennis A Eichenauer, Ingrid Becker, Ina Monsef, Andreas Engert
BACKGROUND: Efficacy and the risk of severe late effects have to be well-balanced in treatment of Hodgkin lymphoma (HL). Late adverse effects include secondary malignancies which often have a poor prognosis. To synthesise evidence on the risk of secondary malignancies after current treatment approaches comprising chemotherapy and/or radiotherapy, we performed a meta-analysis based on individual patient data (IPD) from patients treated for newly diagnosed HL. OBJECTIVES: We investigated several questions concerning possible changes in the risk of secondary malignancies when modifying chemotherapy or radiotherapy (omission of radiotherapy, reduction of the radiation field, reduction of the radiation dose, use of fewer chemotherapy cycles, intensification of chemotherapy)...
September 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28895024/tuberculosis-meningitis
#14
REVIEW
Kassem Bourgi, Christina Fiske, Timothy R Sterling
PURPOSE OF REVIEW: As the most severe form of tuberculosis (TB), TB meningitis disproportionately affects developing countries and results in significant morbidity and mortality. In this report, we review recent updates in the epidemiology, diagnosis, and management of TB meningitis. RECENT FINDINGS: Young children and people living with HIV continue to be at highest risk for TB meningitis. Early diagnosis remains challenging, especially since conventional diagnostic tests have sub-optimal sensitivity and specificity...
September 11, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28894332/breast-cancer-screening-updated-recommendations-of-the-brazilian-college-of-radiology-and-diagnostic-imaging-brazilian-breast-disease-society-and-brazilian-federation-of-gynecological-and-obstetrical-associations
#15
Linei Augusta Brolini Dellê Urban, Luciano Fernandes Chala, Selma di Pace Bauab, Marcela Brisighelli Schaefer, Radiá Pereira Dos Santos, Norma Medicis de Albuquerque Maranhão, Ana Lucia Kefalas, José Michel Kalaf, Carlos Alberto Pecci Ferreira, Ellyete de Oliveira Canella, João Emílio Peixoto, Heverton Leal Ernesto de Amorim, Helio Sebastião Amâncio de Camargo Junior
OBJECTIVE: To present the current recommendations for breast cancer screening in Brazil, as devised by the Brazilian College of Radiology and Diagnostic Imaging, the Brazilian Breast Disease Society, and the Brazilian Federation of Gynecological and Obstetrical Associations. MATERIALS AND METHODS: We analyzed scientific studies available in the Medline and Lilacs databases. In the absence of evidence, the recommendations reflected the consensus of a panel of experts...
July 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28893637/advances-in-the-diagnosis-of-bovine-besnoitiosis-current-options-and-applications-for-control
#16
REVIEW
Daniel Gutiérrez-Expósito, Ignacio Ferre, Luis M Ortega-Mora, Gema Álvarez-García
Bovine besnoitiosis, which is caused by the tissue cyst-forming intracellular parasite Besnoitia besnoiti, is a chronic and debilitating disease that is responsible for severe economic losses in the cattle raised under extensive husbandry systems. The absence of vaccines, treatments or a health scheme at local, national and international levels has led to a rapid spread of bovine besnoitiosis from western Europe towards eastern countries and northwards. Moreover, this parasitic disease is widely present in many sub-Saharan countries...
September 9, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28893168/an-e-chart-review-of-chaplains-interventions-and-outcomes-a-quality-improvement-and-documentation-practice-enhancement-project
#17
Vivian B Stang
In Canada, the spiritual care landscape in health care settings is becoming more regulated and standardized documentation is part of this rigorous environment. Staff chaplains at The Ottawa Hospital participated in a Quality Improvement project that aimed to advance patient-centered care through better charting practices. A sample of 104 spiritual-care assessments that had been posted on the patient electronic health record was examined. This chart review focused on chaplains' activities that were reported as interventions as well as chaplain-reported outcomes for the patient...
September 2017: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/28891129/gastric-cancer-basic-aspects
#18
REVIEW
Silvia Molina-Castro, Joana Pereira-Marques, Ceu Figueiredo, Jose C Machado, Christine Varon
Gastric cancer is one of the most incident and deadliest malignancies in the world. Gastric cancer is a heterogeneous disease and the end point of a long and multistep process, which results from the stepwise accumulation of numerous (epi)genetic alterations, leading to dysregulation of oncogenic and tumor suppressor pathways. Gastric cancer stem cells have emerged as fundamental players in cancer development and as contributors to gastric cancer heterogeneity. For this special issue, we will report last year's update on the gastric cancer molecular classification, and in particular address the gastric cancer groups who could benefit from immune checkpoint therapy...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28890824/gemcitabine-and-capecitabine-for-advanced-biliary-cancer
#19
Emmanuel Gabriel, Shipra Gandhi, Kristopher Attwood, Boris Kuvshinoff, Steven Hochwald, Renuka Iyer
BACKGROUND: Gemcitabine with capecitabine (gem-cap) is an established regimen for advanced biliary cancer (ABC) supported by our previously reported phase II trial. Here, we provide our updated experience. METHODS: Single institution, retrospective study from 2005 to 2015 of ABC treated with gem-cap. RESULTS: A total of 372 patients with ABC were identified, of whom 227 (61.0%) were treated with chemotherapy. 153 patients (67.4%) received gem-cap, of which 129 (56...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890810/updated-survival-outcomes-and-analysis-of-long-term-survivors-from-the-more-study-on-safety-and-efficacy-of-radioembolization-in-patients-with-unresectable-colorectal-cancer-liver-metastases
#20
Andrew Kennedy, Michael Cohn, Douglas M Coldwell, Alain Drooz, Eduardo Ehrenwald, Adeel Kaiser, Charles W Nutting, Steven C Rose, Eric A Wang, Michael A Savin
BACKGROUND: The Metastatic colorectal cancer liver metastases Outcomes after RadioEmbolization (MORE) study was a retrospective analysis of 606 patients with unresectable colorectal liver metastases treated with radioembolization (RE) using (90)Y-labeled resin microspheres. The first analysis of this study was completed with a last patient follow-up of 77.7 months. We now provide an updated survival analysis through September 15, 2016, with a last patient follow-up of 125 months. METHODS: (90)Y-RE was considered for patients with advanced liver-only or liver-dominant metastatic colorectal cancer which was deemed not suitable for surgery, ablation, or systemic therapy, and which had progressed or become refractory to at least one line of systemic therapy...
August 2017: Journal of Gastrointestinal Oncology
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