Jian Wang, Lun Zhang, Hui Xin, Ya Guo, Baokang Zhu, Liqian Su, Shanshan Wang, Jiali Zeng, Qingru Chen, Rui Deng, Ziyan Wang, Jie Wang, Xiaobao Jin, Shuiqing Gui, Yinghua Xu, Xuemei Lu
Oral colon-targeted drug delivery systems (OCDDs) are designed to deliver the therapeutic agents to colonic disease sites to improve the effectiveness of drug treatment, increase bioavailability, and reduce systemic side effects and are beneficial for the treatment of colorectal cancer (CRC) and inflammatory bowel disease (IBD). However, concerns about the biosafety of OCDDs are increasing, and changes in the physiological environment of the gastrointestinal tract can affect the therapeutic efficacy of the drug...
September 6, 2022: Acta Biomaterialia