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https://www.readbyqxmd.com/read/29772681/global-asbestos-disaster
#1
Sugio Furuya, Odgerel Chimed-Ochir, Ken Takahashi, Annette David, Jukka Takala
Introduction : Asbestos has been used for thousands of years but only at a large industrial scale for about 100⁻150 years. The first identified disease was asbestosis, a type of incurable pneumoconiosis caused by asbestos dust and fibres. The latest estimate of global number of asbestosis deaths from the Global Burden of Disease estimate 2016 is 3495. Asbestos-caused cancer was identified in the late 1930's but despite today's overwhelming evidence of the strong carcinogenicity of all asbestos types, including chrysotile, it is still widely used globally...
May 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29770845/real-world-study-of-a-novel-prognostic-scoring-system-for-a-more-precise-prognostication-and-better-clinical-treatment-guidance-in-stages-ii-and-iii-colon-cancer
#2
Qi Liu, Yanlei Ma, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li
PURPOSE: This study aimed to improve the American Joint Committee on Cancer (AJCC) Tumor Node Metastases (TNM) staging system and demonstrate the improvement in prognostic accuracy and clinical management guidance in colon cancer using the novel prognostic score (P score). METHODS: Eligible patients were identified using the Surveillance, Epidemiology, and End Results database. A P score (based on age, tumor size, and tumor grade) was assigned to each patient. The Cox proportional hazards regression analyses were performed to identify independent factors associated with prognosis...
May 16, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29765958/current-perspectives-on-opisthorchiasis-control-and-cholangiocarcinoma-detection-in-southeast-asia
#3
REVIEW
Narong Khuntikeo, Attapol Titapun, Watcharin Loilome, Puangrat Yongvanit, Bandit Thinkhamrop, Nittaya Chamadol, Thidarat Boonmars, Teerachai Nethanomsak, Ross H Andrews, Trevor N Petney, Paiboon Sithithaworn
Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainland Southeast. To reduce this health burden, a comprehensive prevention and control program for opisthorchiasis, as well as CCA, is required. In this review, our aim is to provide a brief update of the current situation regarding the natural history of opisthorchiasis and health burden of CCA in Southeast Asia...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#4
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29763460/lipophilic-statins-limit-cancer-cell-growth-and-survival-via-involvement-of-akt-signaling
#5
Colin H Beckwitt, Keisuke Shiraha, Alan Wells
The HMG-CoA reductase inhibitors, statins, have been used as lipid lowering drugs for decades and several epidemiological studies suggest statin usage correlates with a decreased incidence of cancer specific mortality in patients. However, the mechanism of this mortality benefit remains unclear. Here, we demonstrate that statin drug lipophilicity and affinity for its target enzyme, HMGCR, determine their growth suppressive potency against various tumor cell lines. The lipophilic atorvastatin decreases cancer cell proliferation and survival in vitro...
2018: PloS One
https://www.readbyqxmd.com/read/29760767/survival-after-cancer-diagnosis-in-a-cohort-of-hiv-positive-individuals-in-latin-america
#6
Valeria I Fink, Cathy A Jenkins, Jessica L Castilho, Anna K Person, Bryan E Shepherd, Beatriz Grinsztejn, Juliana Netto, Brenda Crabtree-Ramirez, Claudia P Cortés, Denis Padgett, Karu Jayathilake, Catherine McGowan, Pedro Cahn
Background: This study aimed to evaluate trends and predictors of survival after cancer diagnosis in persons living with HIV in the Caribbean, Central, and South America network for HIV epidemiology cohort. Methods: Demographic, cancer, and HIV-related data from HIV-positive adults diagnosed with cancer ≤ 1 year before or any time after HIV diagnosis from January 1, 2000-June 30, 2015 were retrospectively collected. Cancer cases were classified as AIDS-defining cancers (ADC) and non-AIDS-defining cancers (NADC)...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29756240/vitamin-d-intake-and-survival-and-recurrence-in-head-and-neck-cancer-patients
#7
Eva B Yokosawa, Anna E Arthur, Katie M Rentschler, Gregory T Wolf, Laura S Rozek, Alison M Mondul
OBJECTIVES/HYPOTHESIS: With an unacceptably low 5-year survival rate and few identified modifiable factors that affect head and neck cancer (HNC) outcomes, HNC survival remains an important public health problem. Vitamin D has been shown to be associated with immune reactivity and improved outcomes for some cancer sites, but findings are mixed, and few studies have examined vitamin D in relation to HNC. This study aimed to assess the association between vitamin D intake and survival outcomes in HNC patients...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29753578/racial-ethnic-disparities-in-end-of-life-care-quality-among-lung-cancer-patients-a-seer-medicare-based-study
#8
Siddharth Karanth, Suja S Rajan, Gulshan Sharma, Jose-Miguel Yamal, Robert O Morgan
INTRODUCTION: Cancer end-of-life care and associated racial-ethnic disparities have been in focus during the last few years due to concerns regarding subjective care variations and poor quality of care. Given the high mortality rate and disease burden of lung cancer, end-of-life care quality is particularly crucial for this disease. This study uses previously validated measures and examines racial-ethnic disparities in lung cancer end-of-life care quality. METHODS: This study involves retrospective analysis of patients ≥66 years, who were diagnosed with stage I-IV lung cancer, and who died on or before December 31, 2013, using the Surveillance Epidemiology and End Result-Medicare data from 1991-2013...
May 10, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29742925/widowed-status-increases-the-risk-of-death-in-vulvar-cancer
#9
San-Gang Wu, Qing-Jiang Lin, Feng-Yan Li, Jia-Yuan Sun, Zhen-Yu He, Juan Zhou
AIM: To evaluate the effect of marital status on survival of patients with vulvar cancer. MATERIALS & METHODS: A total of 4001 patients with vulvar cancer were included from the Surveillance, Epidemiology, and End Results database. Statistical analyses were performed using χ2 test, Kaplan-Meier method, Cox regression proportional hazards and a 1:1 propensity score-matching. RESULTS: The 8-year vulvar cancer-related survival in married, divorced, single and widowed patients were 78...
May 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29742278/conditional-relative-survival-among-long-term-survivors-of-adolescent-and-young-adult-cancers
#10
Chelsea Anderson, Andrew B Smitherman, Hazel B Nichols
BACKGROUND: Many studies have examined long-term outcomes after childhood cancer, but few address outcomes for adolescent and young adult (AYA; those aged 15-39 years) cancer survivors. Conditional survival reflects changing mortality risk with time since cancer diagnosis and is a useful measure for planning long-term follow-up care. METHODS: Using the Surveillance, Epidemiology, and End Results registry 9 database, the authors identified a cohort of AYA patients diagnosed with a first malignant cancer between 1973 and 2009 and followed through 2014...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29740894/epidemiology-of-prostate-cancer-in-asian-countries
#11
REVIEW
Takahiro Kimura, Shin Egawa
The incidence of prostate cancer has been increasing worldwide in recent years. The GLOBOCAN project showed that prostate cancer was the second most frequently diagnosed cancer and the fifth leading cause of cancer mortality among men worldwide in 2012. This trend has been growing even in Asian countries, where the incidence had previously been low. However, the accuracy of data about incidence and mortality as a result of prostate cancer in some Asian countries is limited. The cause of this increasing trend is multifactorial...
May 8, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29737422/quantitative-health-impact-of-indoor-radon-in-france
#12
Roula Ajrouche, Candice Roudier, Enora Cléro, Géraldine Ielsch, Didier Gay, Jérôme Guillevic, Claire Marant Micallef, Blandine Vacquier, Alain Le Tertre, Dominique Laurier
Radon is the second leading cause of lung cancer after smoking. Since the previous quantitative risk assessment of indoor radon conducted in France, input data have changed such as, estimates of indoor radon concentrations, lung cancer rates and the prevalence of tobacco consumption. The aim of this work was to update the risk assessment of lung cancer mortality attributable to indoor radon in France using recent risk models and data, improving the consideration of smoking, and providing results at a fine geographical scale...
May 8, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29732918/cervical-cancer-sociodemographic-and-diagnostic-disparities-in-florida-a-population-based-study-1981-2013-by-stage-at-presentation
#13
Aliyah Gauri, Sarah E Messiah, Layla A Bouzoubaa, Kevin J Moore, Tulay Koru-Sengul
OBJECTIVE: Florida has one of the highest cervical cancer mortality rates and socioeconomically diverse populations in the United States. We used statewide population-based cancer registry data to assess disparities in cervical cancer stage at diagnosis. DESIGN: Primary invasive adult female cervical cancer patients in the Florida Cancer Data Registry (1981-2013) were linked with 2000 United States Census data. Early (localized) and advanced (regional and distant) stage at diagnosis was assessed by age, race, ethnicity, neighborhood socioeconomic-, marital-, and smoking- status...
May 5, 2018: Ethnicity & Health
https://www.readbyqxmd.com/read/29727804/marital-status-and-survival-in-patients-with-rectal-cancer-an-analysis-of-the-surveillance-epidemiology-and-end-results-seer-database
#14
Xiangyang Wang, Weilan Cao, Chenguo Zheng, Wanle Hu, Changbao Liu
BACKGROUND: Marital status has been validated as an independent prognostic factor for survival in several cancer types, but is controversial in rectal cancer (RC). The objective of this study was to investigate the impact of marital status on the survival outcomes of patients with RC. METHODS: We extracted data of 27,498 eligible patients diagnosed with RC between 2004 and 2009 from the Surveillance, Epidemiology and End Results (SEER) database. Patients were categorized into married, never married, divorced/separated and widowed groups...
May 1, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29726951/walnut-consumption-alters-the-gastrointestinal-microbiota-microbially-derived-secondary-bile-acids-and-health-markers-in-healthy-adults-a-randomized-controlled-trial
#15
Hannah D Holscher, Heather M Guetterman, Kelly S Swanson, Ruopeng An, Nirupa R Matthan, Alice H Lichtenstein, Janet A Novotny, David J Baer
Background: Epidemiologic data suggest that diets rich in nuts have beneficial health effects, including reducing total and cause-specific mortality from cancer and heart disease. Although there is accumulating preclinical evidence that walnuts beneficially affect the gastrointestinal microbiota and gut and metabolic health, these relations have not been investigated in humans. Objective: We aimed to assess the impact of walnut consumption on the human gastrointestinal microbiota and metabolic markers of health...
May 3, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29726618/metformin-s-antitumour-and-anti-angiogenic-activities-are-mediated-by-skewing-macrophage-polarization
#16
Ji-Chang Wang, Xin Sun, Qiang Ma, Gui-Feng Fu, Long-Long Cong, Hong Zhang, De-Fu Fan, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Guang-Yue Li, Pei-Jun Liu
Beneficial effects of metformin on cancer risk and mortality have been proved by epidemiological and clinical studies, thus attracting research interest in elucidating the underlying mechanisms. Recently, tumour-associated macrophages (TAMs) appeared to be implicated in metformin-induced antitumour activities. However, how metformin inhibits TAMs-induced tumour progression remains ill-defined. Here, we report that metformin-induced antitumour and anti-angiogenic activities were not or only partially contributed by its direct inhibition of functions of tumour and endothelial cells...
May 4, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29726125/long-term-oncological-outcomes-of-local-excision-versus-radical-resection-for-early-colorectal-cancer-in-young-patients-without-preoperative-chemoradiotherapy-a-population-based-propensity-matching-study
#17
Bin Cao, Li Min, Shengtao Zhu, Haiyun Shi, Shutian Zhang
The incidence and mortality of colorectal carcinoma are rising in young adults. This population-based propensity matching study aimed to compare long-term oncological outcomes of local excision with radical resection for early localized colorectal cancer (CRC) in young patients without preoperative chemoradiotherapy. Patients under 45 years old with T1 colon or rectal adenocarcinoma who underwent local excision or radical resection were included from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2014...
May 3, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29724482/physician-visits-and-the-timing-of-skeletal-related-events-among-men-newly-diagnosed-with-metastatic-prostate-cancer-a-cohort-analysis
#18
Eberechukwu Onukwugha, Husam Albarmawi, Kai Sun, C Daniel Mullins, Abdalla Aly, Arif Hussain
INTRODUCTION: Men diagnosed with metastatic prostate cancer (PCa) are at increased risk for skeletal complications which are associated with significant morbidity and mortality. Although both the urologist and the medical oncologist play important roles in the management of patients with advanced PCa, there is limited information regarding their role in the context of skeletal complications. The current study investigated these relationships among newly diagnosed metastatic patients with PCa...
April 30, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29723398/trends-in-incidence-and-5-year-mortality-in-men-with-newly-diagnosed-metastatic-prostate-cancer-a-population-based-analysis-of-2-national-cohorts
#19
John T Helgstrand, Martin A Røder, Nina Klemann, Birgitte G Toft, Daphne Y Lichtensztajn, James D Brooks, Klaus Brasso, Ben Vainer, Peter Iversen
BACKGROUND: Early detection has increased prostate cancer (PCa) incidence. Randomized trials have demonstrated that early detection reduces the incidence of de novo metastatic PCa. Concurrently, life-prolonging treatments have been introduced for patients with advanced PCa. On a populations-based level, the authors analyzed whether early detection and improved treatments changed the incidence and 5-year mortality of men with de novo metastatic PCa. METHODS: Men diagnosed with PCa during the periods 1980 to 2011 and 1995 to 2011 were identified in the US Surveillance, Epidemiology, and End Results (SEER) program and the Danish Prostate Cancer Registry (DaPCaR), respectively, and stratified according to period of diagnosis...
May 3, 2018: Cancer
https://www.readbyqxmd.com/read/29721162/does-perioperative-chemotherapy-improve-survival-in-upper-tract-urothelial-carcinoma-a-population-based-analysis
#20
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Rashid Sayyid, Girish S Kulkarni, Robert J Hamilton, Neil E Fleshner
Objectives: To evaluate the utilization and outcomes of perioperative chemotherapy in non-metastatic UTUC patients over the past decade using a large national database. Methods: All patients aged 18 and older diagnosed with non-metastatic UTUC between 2004 and 2013 were identified within the Surveillance, Epidemiology and End Results (SEER) database. Relevant clinical data was collected and predictors of cancer specific mortality (CSM) and other cause mortality (OCM) were analyzed...
April 10, 2018: Oncotarget
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