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Cancer mortality epidemiology

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https://www.readbyqxmd.com/read/29341266/merkel-cell-carcinoma-in-france-a-registries-based-comprehensive-epidemiological-survey
#1
M Fondain, O Dereure, Z Uhry, A V Guizard, A S Woronoff, M Colonna, F Molinie, S Bara, M Velten, E Marrer, P Grosclaude, B Lapôtre-Ledoux, B Tretarre, B Guillot
BACKGROUND: Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma. Owing to its low incidence, epidemiological data are scarce and have never been analysed in France to identify the main epidemiological trends. METHODS: Data from MCC patients diagnosed between 1998 and 2010 were obtained from 11 French cancer registries in the FRANCIM network. The main epidemiological characteristics of MCC were investigated between 2006 and 2010 because comprehensive data were only available for this period...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29339806/tumor-characteristics-treatments-and-oncological-outcomes-of-prostate-cancer-in-men-aged-%C3%A2-50-years-a-population-based-study
#2
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
January 16, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29335369/the-rate-of-telomere-loss-is-related-to-maximum-lifespan-in-birds
#3
Gianna M Tricola, Mirre J P Simons, Els Atema, Raoul K Boughton, J L Brown, Donald C Dearborn, G Divoky, John A Eimes, Charles E Huntington, Alexander S Kitaysky, Frans A Juola, David B Lank, Hannah P Litwa, Ellis G A Mulder, Ian C T Nisbet, Kazuo Okanoya, Rebecca J Safran, Stephan J Schoech, Elizabeth A Schreiber, Paul M Thompson, Simon Verhulst, Nathaniel T Wheelwright, David W Winkler, Rebecca Young, Carol M Vleck, Mark F Haussmann
Telomeres are highly conserved regions of DNA that protect the ends of linear chromosomes. The loss of telomeres can signal an irreversible change to a cell's state, including cellular senescence. Senescent cells no longer divide and can damage nearby healthy cells, thus potentially placing them at the crossroads of cancer and ageing. While the epidemiology, cellular and molecular biology of telomeres are well studied, a newer field exploring telomere biology in the context of ecology and evolution is just emerging...
March 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29330308/survival-outcomes-of-primary-cutaneous-t-cell-lymphoma-in-hiv-infected-patients-a-national-population-based-study
#4
Jianhong Wang, Rong Liang, Caixia Hao, Xiangxiang Liu, Na Zhang, Xiaohui Duan, Hongjuan Dong, Baoxia Dong, Hongtao Gu, Guangxun Gao, Tao Zhang, Qingxian Bai, Xiequn Chen
This study aimed to investigate clinical characteristics and survival outcomes of primary cutaneous T-cell lymphoma (CTCL) in HIV-infected and non-HIV-infected patients. All data were from the Surveillance, Epidemiology, and End Results program, 1973-2013, of the U.S. National Cancer Institute. Data of 318 HIV-infected patients and 1272 non-HIV-infected patients with primary CTCL were analyzed. Endpoints were overall survival and cancer-specific mortality. Independent variables included demographics, pre-existing malignancy, treatments, and environmental factors...
January 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29329337/mitochondrial-dna-ancestry-hpv-infection-and-the-risk-of-cervical-cancer-in-a-multiethnic-population-of-northeastern-argentina
#5
Ines Badano, Daiana J Sanabria, Maria E Totaro, Samara Rubinstein, Juan A Gili, Domingo J Liotta, Maria A Picconi, Rodolfo H Campos, Theodore G Schurr
BACKGROUND: Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the relationship between mitochondrial DNA (mtDNA) ancestry, HPV infection, and development of cervical lesions/cancer in women from the city of Posadas in Misiones Province. METHODS: Two hundred and sixty-one women, including 92 cases of patients diagnosed with cervical lesions and 169 controls, were analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29320896/mortality-rate-and-oral-health-a-cohort-study-over-44-years-in-the-county-of-stockholm
#6
Leif Jansson, Hero Kalkali, Freha Mulk Niazi
OBJECTIVE: To study the association between oral health and all-cause mortality rate over 44 years. In addition, the specific relations between oral health and death caused by cardiovascular disease (CVD), cancer or other reasons were investigated. MATERIALS AND METHODS: An epidemiological investigation studying the oral health of the population consisting of 1393 randomly selected subjects was performed in the County of Stockholm. The individuals were invited to a clinical examination, an interview and a radiographic examination...
January 11, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29314093/hospice-care-in-medicare-patients-with-primary-liver-cancer-the-impact-on-resource-utilisation-and-mortality
#7
N Fukui, P Golabi, M Otgonsuren, L de Avila, H Bush, Z M Younossi
BACKGROUND: Few studies have assessed the impact of hospice care in patients with primary liver cancer. AIM: To examine the determinants of hospice care and its effects on resource utilisation and survival among Medicare beneficiaries with primary liver cancer. METHODS: We utilised the Surveillance, Epidemiology and End result Registry (SEER) database from 2002 to 2009 for this cross-sectional study. A total of 3385 patients with primary liver cancer were included...
January 3, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29313949/cancer-statistics-2018
#8
Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data, available through 2014, were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data, available through 2015, were collected by the National Center for Health Statistics...
January 4, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29313822/direct-adjustment-for-confounding-by-smoking-reduces-radiation-related-cancer-risk-estimates-of-mortality-among-male-nuclear-workers-in-japan-1999-2010
#9
Shin'ichi Kudo, Jun'ichi Ishida, Keiko Yoshimoto, Shoichi Mizuno, Sumio Ohshima, Hiroshige Furuta, Fumiyoshi Kasagi
The causal relationship between protracted exposure to low-dose rate radiation and health effects remains unclear despite extensive international studies of nuclear workers. One reason is that radiation epidemiological studies that adjust for smoking, which heavily influences mortality, have been limited. In the present study, we examined radiation-related cancer risk by directly assessing the possible confounding effect of smoking, using data from two questionnaire surveys performed among Japanese nuclear workers in 1997 and 2003...
January 9, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29312566/trends-in-colorectal-cancer-mortality-in-hispanics-a-seer-analysis
#10
Afsaneh Barzi, Dongyun Yang, Sayedamin Mostofizadeh, Heinz-Josef Lenz
Background: Colorectal cancer (CRC) mortality among Hispanics is lower than Non-Hispanic Whites (NHW). If Hispanics receive equitable care and achieve the same degree of health benefit, their trend of better survival should be maintained. This study assesses mortality trends among Hispanics overtime to compare their survival improvement with NHW. Methods: We used the Incidence-Based Mortality database of the Surveillance, Epidemiology, and End Results Program (SEER) to assess the mortality gap, which is defined as the difference in stage-specific mortality between NHWs and Hispanics, and currently has an advantage for Hispanics...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311132/the-epidemiology-of-prostate-cancer
#11
Claire H Pernar, Ericka M Ebot, Kathryn M Wilson, Lorelei A Mucci
Prostate cancer is a major cause of disease and mortality among men, and each year 1.6 million men are diagnosed with and 366,000 men die of prostate cancer. In this review, we discuss the state of evidence for specific genetic, lifestyle, and dietary factors associated with prostate cancer risk. Given the biological heterogeneity of this cancer, we focus on risk factors for advanced or fatal prostate cancer. First, we provide descriptive epidemiology statistics and patterns for prostate cancer incidence and mortality around the world...
January 8, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29311051/relationship-between-state-level-google-online-search-volume-and-cancer-incidence-in-the-united-states-retrospective-study
#12
Charles A Phillips, Allison Barz Leahy, Yimei Li, Marilyn M Schapira, L Charles Bailey, Raina M Merchant
BACKGROUND: In the United States, cancer is common, with high morbidity and mortality; cancer incidence varies between states. Online searches reflect public awareness, which could be driven by the underlying regional cancer epidemiology. OBJECTIVE: The objective of our study was to characterize the relationship between cancer incidence and online Google search volumes in the United States for 6 common cancers. A secondary objective was to evaluate the association of search activity with cancer-related public events and celebrity news coverage...
January 8, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29306879/observational-study-of-the-differential-impact-of-time-varying-depressive-symptoms-on-all-cause-and-cause-specific-mortality-by-health-status-in-community-dwelling-adults-the-regards-study
#13
Nathalie Moise, Yulia Khodneva, Deanna Pereira Jannat-Khah, Joshua Richman, Karina W Davidson, Ian M Kronish, Jonathan Shaffer, Monika M Safford
OBJECTIVE: To assess the association between time-varying depressive symptoms with all-cause and cause-specific mortality. DESIGN: The REGARDS (Reasons for Geographic and Racial Differences in Stroke) is a national, population-based longitudinal study conducted from 2003 to 2007. SETTING: General continental US communities. PARTICIPANTS: 29 491 black and white US adults ≥45 years randomly sampled within race-sex-geographical strata...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306788/epithelial-ovarian-cancer-mortality-among-hispanic-women-sub-ethnic-disparities-and-survival-trend-across-time-an-analysis-of-seer-1992-2013
#14
Chen Chen, Talar W Markossian, Abigail Silva, Yelena N Tarasenko
BACKGROUND: Over the past half century the proportion of Hispanics in the US population has been steadily increasing, and groups of Hispanic origin have diversified. Despite notable racial and ethnic disparities in ovarian cancer (OC) mortality, population-based studies on OC among Hispanic females are lacking. OBJECTIVES: To examine sub-ethnic disparities in OC mortality and survival trends using the Surveillance, Epidemiology, and End Results Program (SEER) 18 data on Hispanic women diagnosed with epithelial OC during 1992-2013...
January 4, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29306731/the-impact-of-lymph-node-metastases-burden-at-radical-prostatectomy
#15
Felix Preisser, Michele Marchioni, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Raisa S Pompe, Francesco Montorsi, Fred Saad, Firas Abdollah, Thomas Steuber, Hans Heinzer, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: We hypothesized that a cut-off in positive lymph node (LN) counts may discriminate between cancer-specific mortality (CSM) rates in clinically localized prostate cancer patients treated with radical prostatectomy (RP). OBJECTIVE: To test this relationship, we relied on different LN count cut-offs, as well as the continuously coded number of positive LNs (NPN). METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2014), we identified patients with D'Amico intermediate- or high-risk characteristics who underwent RP and pelvic LN dissection, regardless of pathologic LN stage...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29296849/risk-and-timing-of-cardiovascular-death-among-patients-with-myelodysplastic-syndromes
#16
Andrew M Brunner, Traci M Blonquist, Gabriela S Hobbs, Philip C Amrein, Donna S Neuberg, David P Steensma, Gregory A Abel, Amir T Fathi
Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders associated with progression to leukemia and poor survival. Clonal hematopoiesis in people without an MDS diagnosis carries an increased risk of cardiovascular death. Many clonally restricted mutations are shared between patients with MDS and those with non-MDS clonal hematopoiesis; therefore, we evaluated the risk of cardiovascular death among patients with MDS. We evaluated adults with MDS in the Surveillance, Epidemiology, and End Results database of the National Cancer Institute and compared them with the general population living in the same states...
October 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29290972/survival-benefits-of-gastrectomy-in-gastric-cancer-patients-with-stage-iv-a-population-based-study
#17
Xingkang He, Sanchuan Lai, Tingting Su, Yangyang Liu, Yue Ding, Sheng Quan, Jianmin Si, Leimin Sun
Objective: The aim of the current study is to investigate the role of gastrectomy for survival among metastatic gastric cancer patients. Results: We finally identified 12,986 eligible patients with stage IV GC between 2004 and 2012, including 1,981 (15.3%) patients with gastrectomy and 11,005 (84.7%) without surgery. The median overall survival time for patients with and without surgery were 9.0 (95%, 8.3-9.7) and 4.0 (95%, 3.9-4.1) months respectively. Patients who received gastrectomy had a significantly better survival outcome compared with those without surgery (P < 0...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290269/how-does-autoimmune-disease-impact-treatment-and-outcomes-among-patients-with-lung-cancer-a-national-seer-medicare-analysis
#18
Saad A Khan, Sandi L Pruitt, Lei Xuan, Una Makris, David E Gerber
BACKGROUND: The advent of cancer immunotherapy has made autoimmune disease in oncology populations clinically important. We analyzed the association of autoimmune disease with treatment and outcomes among lung cancer patients. METHODS: Using linked Surveillance Epidemiology and End Results (SEER)-Medicare data, we identified lung cancer patients diagnosed between 1992 and 2009 with autoimmune diseases. We recorded number and timing of autoimmune disease diagnoses, lung cancer treatment, and markers of healthcare utilization including emergency department visits, hospitalizations, and outpatient visits...
January 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29288121/contemporary-incidence-outcomes-of-prostate-cancer-lymph-node-metastases
#19
Adrien N Bernstein, Jonathan E Shoag, Ron Golan, Joshua A Halpern, Edward M Schaeffer, Wei-Chun Hsu, Paul L Nguyen, Art Sedrakyan, Ronald C Chen, Scott E Eggener, Jim C Hu
PURPOSE: The incidence of localized prostate cancer has declined with shifts in prostate cancer screening. While recent population-based studies demonstrate a stable incidence of loco-regional prostate cancer, this categorized organ-confined, extra-prostatic and lymph node positive disease together. The contemporary incidence of prostate cancer with pelvic lymph node metastases (PLNM) however, remains unknown. METHODS: We used Surveillance, Epidemiology and End Results (SEER) from 2004 to 2014 to identify men diagnosed with prostate cancer...
December 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29283089/epidemiology-of-renal-cancer-in-developing-countries-review-of-the-literature
#20
Mauricio Medina-Rico, Hugo López Ramos, Manuel Lobo, Jorge Romo, Juan Guillermo Prada
INTRODUCTION: Renal cell carcinoma (RCC) is the ninth most common cancer in men, and the 14th most common cancer in women. It has been reported that the incidence of RCC is rising. These changes are more common in developed countries because of better screening programs and disease registry. The aim of this article is to review the epidemiology of RCC around the world. METHODS: A literature review on four databases was performed: PubMed, Embase, Lilacs, and Scielo...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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