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Hypometabolism

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https://www.readbyqxmd.com/read/28934619/distinct-brain-metabolic-patterns-separately-associated-with-cognition-motor-function-and-aging-in-parkinson-s-disease-dementia
#1
Ji Hyun Ko, Audrey Katako, Maram Aljuaid, Andrew L Goertzen, Andrew Borys, Douglas E Hobson, Seok Min Kim, Chong Sik Lee
We explored whether patients with Parkinson's disease dementia (PDD) show a distinct spatial metabolic pattern that characterizes cognitive deficits in addition to motor dysfunction. Eighteen patients with PDD underwent 3 separate positron emission tomography sessions with [(18)F]fluorodeoxyglucose (for glucose metabolism), fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (for dopamine transporter density) and Pittsburgh compound-B (for beta-amyloid load). We confirmed in PDD versus normal controls, overall hypometabolism in the posterior and prefrontal brain regions accompanied with hypermetabolism in subcortical structures and the cerebellar vermis...
August 31, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28933063/diabesity-and-brain-energy-metabolism-the-case-of-alzheimer-s-disease
#2
Susana Cardoso, Raquel Seiça, Paula I Moreira
It is widely accepted that high calorie diets and a sedentary lifestyle sturdily influence the incidence and outcome of type 2 diabetes and obesity, which can occur simultaneously, a situation called diabesity. Tightly linked with metabolic and energy regulation, a close association between diabetes and Alzheimer's disease (AD) has been proposed. Among the common pathogenic mechanisms that underpin both conditions, insulin resistance, brain glucose hypometabolism, and metabolic dyshomeostasis appear to have a pivotal role...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28929339/intranasal-insulin-ameliorates-cerebral-hypometabolism-neuronal-loss-and-astrogliosis-in-streptozotocin-induced-alzheimer-s-rat-model
#3
Yanxing Chen, Zhangyu Guo, Yan-Fang Mao, Tingting Zheng, Baorong Zhang
Intracerebroventricular injection of streptozotocin (ICV-STZ) in rodents leads to cognitive impairments and several pathological changes like Alzheimer's disease (AD). However, there is hardly any research about the effect of ICV-STZ on regional cerebral glucose metabolism in rodents. Previous studies have demonstrated that intranasal insulin improves cognition in AD patients. However, the underlying mechanism remains elusive. Here, we treated the ICV-STZ rats with daily intranasal delivery of insulin (2 U/day) for 6 consecutive weeks, then monitored (18)F-fluorodeoxyglucose ((18)F-FDG) uptake using a high-resolution small-animal positron emission tomography (microPET) and studied the expression of neuronal nuclei (NeuN) and glial fibrillary acidic protein (GFAP) using immunohistochemical staining...
September 19, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28928072/orbitofrontal-epilepsy-case-series-and-review-of-literature
#4
Imane Samah Chibane, Olivier Boucher, François Dubeau, Thi Phuoc Yen Tran, Ismail Mohamed, Richard McLachlan, R Mark Sadler, Richard Desbiens, Lionel Carmant, Dang Khoa Nguyen
BACKGROUND: Orbitofrontal epilepsy (OFE) is less known and is poorly characterized in comparison with temporal lobe epilepsy, partly because it is rare and possibly because it is unrecognized and therefore underestimated. OBJECTIVE: This paper aimed to better characterize seizure semiology, presurgical findings, and surgical outcomes in patients with OFE. METHODS: We retrospectively reviewed all confidently established OFE cases from six Canadian epilepsy monitoring units between 1988 and 2014, and in the literature between 1972 and 2017...
September 16, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28919879/automated-online-quantification-method-for-18-f-fdg-positron-emission-tomography-ct-improves-detection-of-the-epileptogenic-zone-in-patients-with-pharmacoresistant-epilepsy
#5
Vanessa Cristina Mendes Coelho, Marcia E Morita, Barbara J Amorim, Celso Darío Ramos, Clarissa L Yasuda, Helder Tedeschi, Enrico Ghizoni, Fernando Cendes
AIMS: To assess the validity of an online method to quantitatively evaluate cerebral hypometabolism in patients with pharmacoresistant focal epilepsy as a complement to the visual analysis of the (18)F-FDG positron emission tomography (PET)/CT exam. METHODS: A total of 39 patients with pharmacoresistant epilepsy and probable focal cortical dysplasia [22 patients with frontal lobe epilepsy (FLE) and 17 with temporal lobe epilepsy (TLE)] underwent a presurgical evaluation including EEG, video-EEG, MRI, and (18)F-FDG PET/CT...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28918694/brain-metabolic-correlates-of-fatigue-in-parkinson-s-disease-a-pet-study
#6
Li Zhang, Tiannv Li, Yongsheng Yuan, Qing Tong, Siming Jiang, Min Wang, Jianwei Wang, Jian Ding, Qinrong Xu, Kezhong Zhang
The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale [HAMD] score ≥ 14), apathy (Apathy Scale [AS] score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale [ESS] score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose PET (FDG-PET) scan...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28906375/correlations-between-clinical-characteristics-and-neuroimaging-in-chinese-patients-with-subtypes-of-frontotemporal-lobe-degeneration
#7
Zhihong Shi, Shuai Liu, Ying Wang, Shuling Liu, Tong Han, Li Cai, Yuying Zhou, Shuo Gao, Yong Ji
The aim of the study was to obtain an overview of the clinical and neuroimaging features of Chinese patients with subtypes of frontotemporal lobe degeneration (FTLD).We evaluated the demographic features, clinical presentation, and lobe atrophy depicted by magnetic resonance imaging (MRI) in 133 patients with FTLD. Two positron emission tomography (PET) scans were performed at baseline: [C]Pittsburgh compound B PET to assess amyloid-β plaque load and [F]fluorodeoxyglucose (FDG) PET to assess glucose metabolism...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28890300/tau-positron-emission-tomography-using-18-f-thk5351-and-cerebral-glucose-hypometabolism-in-alzheimer-s-disease
#8
Jae Myeong Kang, Sang-Yoon Lee, Seongho Seo, Hye Jin Jeong, Sung-Ho Woo, Hyon Lee, Yeong-Bae Lee, Byeong Kil Yeon, Dong Hoon Shin, Kee Hyung Park, Hyejin Kang, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Victor L Villemagne, Joon-Kyung Seong, Duk L Na, Tatsuo Ido, Jaelim Cho, Kyoung-Min Lee, Young Noh
This study aims to evaluate the clinical validity of [(18)F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [(18)F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed...
November 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28882421/-18-f-fdg-pet-hypometabolism-patterns-reflect-clinical-heterogeneity-in-sporadic-forms-of-early-onset-alzheimer-s-disease
#9
Matthieu Vanhoutte, Franck Semah, Adeline Rollin Sillaire, Alice Jaillard, Grégory Petyt, Grégory Kuchcinski, Aurélien Maureille, Xavier Delbeuck, Rachid Fahmi, Florence Pasquier, Renaud Lopes
Until now, hypometabolic patterns and their correlations with neuropsychological performance have not been assessed as a function of the various presentations of sporadic early-onset Alzheimer's disease (EOAD). Here, we processed and analyzed the patients' metabolic maps at the vertex and voxel levels by using a nonparametric, permutation method that also regressed out the effects of cortical thickness and gray matter volume, respectively. The hypometabolism patterns in several areas of the brain were significantly correlated with the clinical manifestations...
November 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28859884/a-network-of-insulin-peptides-regulate-glucose-uptake-by-astrocytes-potential-new-druggable-targets-for-brain-hypometabolism
#10
REVIEW
A M Fernandez, E Hernandez, D Guerrero-Gomez, A Miranda-Vizuete, I Torres Aleman
Astrocytes are major players in brain glucose metabolism, supporting neuronal needs on demand through mechanisms that are not yet entirely clear. Understanding glucose metabolism in astrocytes is therefore of great consequence to unveil novel targets and develop new drugs to restore brain energy balance in pathology. Contrary to what has been held for many years, we now present evidence that insulin, in association with the related insulin-like growth factor I (IGF-I) modulates brain glucose metabolism through a concerted action on astrocytes...
August 30, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28855400/sex-differences-in-alzheimer-risk-brain-imaging-of-endocrine-vs-chronologic-aging
#11
Lisa Mosconi, Valentina Berti, Crystal Quinn, Pauline McHugh, Gabriella Petrongolo, Isabella Varsavsky, Ricardo S Osorio, Alberto Pupi, Shankar Vallabhajosula, Richard S Isaacson, Mony J de Leon, Roberta Diaz Brinton
OBJECTIVE: This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS: Forty-two 40- to 60-year-old cognitively normal women (15 asymptomatic perimenopausal by age [CNT], 13 perimenopausal [PERI], and 14 postmenopausal [MENO]) and 18 age- and education-matched men were examined...
August 30, 2017: Neurology
https://www.readbyqxmd.com/read/28831764/motor-impairment-and-compensation-in-a-hemiparkinsonian-rat-model-correlation-between-dopamine-depletion-severity-cerebral-metabolism-and-gait-patterns
#12
Elena Kordys, Nadine Apetz, Katharina Schneider, Eilidh Duncan, Beatriz Büschbell, Cathrin Rohleder, Michael Sué, Alexander Drzezga, Bernd Neumaier, Lars Timmermann, Heike Endepols
BACKGROUND: In Parkinson's disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment, while hypermetabolism may indicate compensatory activity. In order to associate metabolic patterns with pathophysiological and compensatory mechanisms, we combined resting state [(18)F]FDG-PET (to demonstrate brain metabolism in awake animals), [(18)F]FDOPA-PET (dopamine depletion severity) and gait analysis in a unilateral 6-hydroxydopamine rat model...
August 23, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28804457/association-between-hypometabolism-in-the-supplementary-motor-area-and-fear-of-falling-in-older-adults
#13
Ryota Sakurai, Yoshinori Fujiwara, Masashi Yasunaga, Hiroyuki Suzuki, Kazuyuki Kanosue, Manuel Montero-Odasso, Kenji Ishii
Background: A better understanding of the neural mechanisms that underlie the development of fear of falling (FoF) in seniors may help to detect potential treatable factors and reduce future falls. We therefore investigate the neural correlates of FoF in older adults using (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET). Methods: This cohort study included 117 community-dwelling older adults. At baseline, participants were assessed for FoF, psychiatric symptoms, walking speed, global cognition and cerebral glucose metabolism with FDG-PET...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28766694/musicogenic-reflex-seizures-in-epilepsy-with-glutamic-acid-decarbocylase-antibodies
#14
M Falip, L Rodriguez-Bel, S Castañer, J Miro, S Jaraba, J Mora, J Bas, M Carreño
BACKGROUND: Musicogenic reflex seizures (MRS) are a rare form of seizures described in patients with temporal lobe epilepsy (TLE), mainly of unknown etiology. Epilepsy with antibodies against glutamic acid decarboxylase (GAD-ab) is a form of autoimmune epilepsy for which no specific semiology has been described. AIM OF THE STUDY: To retrospectively review the incidence of MRS in the general epileptic population and in the series of patients with epilepsy and GAD-ab and to describe its clinical and paraclinical characteristics...
August 2, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28757902/resting-brain-activity-related-to-dispositional-mindfulness-a-pet-study
#15
Martin Gartenschläger, Mathias Schreckenberger, Hans-Georg Buchholz, Iris Reiner, Manfred E Beutel, Julia Adler, Matthias Michal
Mindfulness denotes a state of consciousness characterized by receptive attention to and awareness of present events and experiences. As a personality trait, it constitutes the ability to become aware of mental activities such as sensations, images, feelings, and thoughts, and to disengage from judgment, conditioned emotions, and their cognitive processing or automatic inhibition. Default brain activity reflects the stream of consciousness and sense of self at rest. Analysis of brain activity at rest in persons with mindfulness propensity may help to elucidate the neurophysiological basis of this important mental trait...
2017: Mindfulness
https://www.readbyqxmd.com/read/28756378/thalamic-and-cerebellar-hypermetabolism-and-cortical-hypometabolism-during-absence-status-epilepticus
#16
Kei Shimogori, Tadashi Doden, Kazuhiro Oguchi, Takao Hashimoto
We report on a 17-year-old girl with absence status epilepticus who developed recurrent motionless confusional state and continuous generalised 3-4 Hz rhythmic delta waves on electroencephalogram (EEG). The patient had no history of absence, myoclonus or generalised convulsion. Her seizure was resistant to a combination of antiepileptic drugs including carbamazepine. Ictal positron emission tomography using [(18)F]fluorodeoxyglucose ([(18)F]FDG-PET) revealed hypermetabolism of the bilateral thalamus and cerebellum and hypometabolism of the frontal, parietal and posterior cingulate cortices...
July 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28755648/cerebral-pet-glucose-hypometabolism-in-subjects-with-mild-cognitive-impairment-and-higher-eeg-high-alpha-low-alpha-frequency-power-ratio
#17
Davide Vito Moretti, Michela Pievani, Lorenzo Pini, Ugo Paolo Guerra, Barbara Paghera, Giovanni Battista Frisoni
In Alzheimer's disease (AD) research, both 2-deoxy-2-((18)F)fluoro-D-glucose (FDG) positron emission tomography (PET) and electroencephalography (EEG) are reliable investigational modalities. The aim of this study was to investigate the associations between EEG High-alpha/Low-alpha (H-alpha/L-alpha) power ratio and cortical glucose metabolism. A total of 23 subjects with mild cognitive impairment (MCI) underwent FDG-PET and EEG examinations. H-alpha/L-alpha power ratio was computed for each subject and 2 groups were obtained based on the increase of the power ratio...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28754841/in-vivo-retention-of-18-f-av-1451-in-corticobasal-syndrome
#18
Ruben Smith, Michael Schöll, Håkan Widner, Danielle van Westen, Per Svenningsson, Douglas Hägerström, Tomas Ohlsson, Jonas Jögi, Christer Nilsson, Oskar Hansson
OBJECTIVE: To study the usefulness of (18)F-AV-1451 PET in patients with corticobasal syndrome (CBS). METHODS: We recruited 8 patients with CBS, 17 controls, 31 patients with Alzheimer disease (AD), and 11 patients with progressive supranuclear palsy (PSP) from the Swedish BioFINDER study. All patients underwent clinical assessment, (18)F-AV-1451 PET, MRI, and quantification of β-amyloid pathology. A subset of participants also underwent (18)F-FDG-PET. RESULTS: In the 8 patients with CBS, 6 had imaging findings compatible with the corticobasal degeneration pathology and 2 with typical AD pathology...
August 22, 2017: Neurology
https://www.readbyqxmd.com/read/28752644/hypertension-is-associated-with-worse-cognitive-function-and-hippocampal-hypometabolism-in-alzheimer-s-disease
#19
I Moonga, F Niccolini, H Wilson, G Pagano, M Politis
BACKGROUND AND PURPOSE: A growing body of evidence suggests that cardiovascular disease risk factors including hypertension may be linked to sporadic Alzheimer's disease (AD). It is well known that hypertension is associated with cerebrovascular disease and vascular dementia on the basis of vascular remodeling. However, the mechanisms linking hypertension and AD remain unclear. METHODS: We studied 197 patients with AD (86 male; mean age ± SD: 75.8 ± 7.4 years) from the Alzheimer's Disease Neuroimaging Initiative database with (n = 97) and without (n = 100) hypertension...
July 28, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28750498/emerging-clinical-issues-and-multivariate-analyses-in-pet-investigations
#20
Javier Arbizu, Alessandro Giuliani, Jaime Gallego Perez-Larraya, Mario Riverol, Cathrine Jonsson, Berta García-García, Maribel Morales, Laura Imaz, Marco Pagani
PET using 18F-2-fluoro-2-deoxy-D-glucose (FDG-PET) has been gradually introduced in the diagnostic clinical criteria of the most prevalent neurodegenerative diseases. Moreover, an increasing amount of literature have shown that the information provided by FDG-PET enhances the sensitivity of standard imaging biomarkers in less frequent disorders in which an early differential diagnosis can be of paramount relevance for patient management and outcome. Therefore emerging uses of FDG-PET may be important in prion diseases, autoimmune encephalitis and amyotrophic lateral sclerosis...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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