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https://www.readbyqxmd.com/read/28645685/concordance-between-brain-18-f-fdg-pet-and-cerebrospinal-fluid-biomarkers-in-diagnosing-alzheimer-s-disease
#1
S Rubí, A Noguera, S Tarongí, M Oporto, A García, H Vico, A Espino, M J Picado, A Mas, C Peña, G Amer
OBJECTIVES: Cortical posterior hypometabolism on PET imaging with (18)F-FDG (FDG-PET), and altered levels of Aß1-42 peptide, total Tau (tTau) and phosphorylated Tau (pTau) proteins in cerebrospinal fluid (CSF) are established diagnostic biomarkers in Alzheimer's disease (AD). An evaluation has been made of the concordance and relationship between the results of FDG-PET and CSF biomarkers in symptomatic patients with suspected AD. MATERIAL AND METHODS: A retrospective review was carried out on 120 patients with cognitive impairment referred to our Cognitive Neurology Unit, and who were evaluated by brain FDG-PET and a lumbar puncture for CSF biomarkers...
June 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28638971/longer-duration-of-operative-time-enhances-healing-metabolites-and-improves-patient-outcome-after-achilles-tendon-rupture-surgery
#2
Simon Svedman, Olof Westin, Susanna Aufwerber, Gunnar Edman, Katarina Nilsson-Helander, Michael R Carmont, Jón Karlsson, Paul W Ackermann
PURPOSE: The relationship between the duration of operative time (DOT), healing response and patient outcome has not been previously investigated. An enhanced healing response related to DOT may potentiate repair processes, especially in hypovascular and sparsely metabolized musculoskeletal tissues such as tendons. This study aimed to investigate the association between DOT and the metabolic healing response, patient-reported outcome and the rate of post-operative complications after acute Achilles tendon injury...
June 21, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28638030/-characteristics-of-cerebral-glucose-metabolism-in-patients-with-cognitive-impairment-in-parkinson-s-disease
#3
Ju G Homenko, D S Susin, G V Kataeva, Ju A Irishina, I G Zavolokov
AIM: To study the relationship between early cognitive impairment symptoms and cerebral glucose metabolism in different brain regions (according to the positron emission tomography (PET) data) in Parkinson's disease (PD) in order to increase the diagnostic and treatment efficacy. MATERIAL AND METHODS: Two groups of patients with PD (stage I-III), including 11 patients without cognitive disorders and 13 with mild cognitive impairment (MCI), were examined. The control group included 10 age-matched people with normal cognition...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28634382/expression-of-p301l-htau-in-mouse-mec-induces-hippocampus-dependent-memory-deficit
#4
Xinghua Liu, Kuan Zeng, Mengzhu Li, Qun Wang, Rong Liu, Bin Zhang, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wang
Intracellular accumulation of abnormally phosphorylated tau in different types of neurons is a pathological characteristic of Alzheimer's disease (AD). While tau modification and associated neuronal loss and hypometabolism start in the entorhinal cortex (EC) in early AD patients, the mechanism by which mutant P301L hTau leads to dementia is not fully elucidated. Here, we studied the effects of P301L hTau transduction in the medial EC (MEC) of mice on tau phosphorylation and accumulation, and cognitive deficit...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622282/towards-a-neurobiological-understanding-of-alexithymia
#5
REVIEW
Nicolás Meza-Concha, Marcelo Arancibia, Felicia Salas, Rosa Behar, Germán Salas, Hernán Silva, Rocío Escobar
Although the specialized literature on the etiology of alexithymia is controversial, neurobiological research has shown relevant advances. The aim of this review is to analyze the available evidence regarding the neurophysiological bases of alexithymia. A comprehensive review of available articles from Medline/PubMed, EBSCO and SciELO was conducted. Previously, alexithymia was linked to a reduced interhemispheric brain connection. From a childhood traumatic perspective, the right prefrontal cortex and the default mode network would experience alterations, first hypermetabolic (dopaminergic and glutamatergic dysregulation) and then hypometabolic-dissociative (serotonergic and opioid dysregulation), resulting in a distorted interoceptive and emotional awareness...
May 29, 2017: Medwave
https://www.readbyqxmd.com/read/28621620/deep-brain-stimulation-for-the-early-treatment-of-the-minimally-conscious-state-and-vegetative-state-experience-in-14-patients
#6
Darko Chudy, Vedran Deletis, Fadi Almahariq, Petar Marčinković, Jasenka Škrlin, Veronika Paradžik
OBJECTIVE An effective treatment of patients in a minimally conscious state (MCS) or vegetative state (VS) caused by hypoxic encephalopathy or traumatic brain injury (TBI) is not yet available. Deep brain stimulation (DBS) of the thalamic reticular nuclei has been attempted as a therapeutic procedure mainly in patients with TBI. The purpose of this study was to investigate the therapeutic use of DBS for patients in VS or MCS. METHODS Fourteen of 49 patients in VS or MCS qualified for inclusion in this study and underwent DBS...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28615780/converging-neurobiological-evidence-in-primary-polydipsia-resembling-obsessive-compulsive-disorder
#7
Karthick Subramanian, Tess Maria Rajan, Vikas Menon, Ravi Philip Rajkumar
Compulsive water drinking can have phenomenological and pharmacotherapeutic similarities with obsessive-compulsive disorder (OCD). Substantiating neurobiological evidence is lacking for such an association. We report a patient who was referred with a diagnosis of primary polydipsia with no signs of organic pathology in structural neuroimaging. However, positron emission tomography revealed basal ganglia hypometabolism indicating that primary polydipsia with compulsive water drinking is neurobiologically related to OCD...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28615758/regional-cerebral-glucose-metabolism-and-its-association-with-phenotype-and-cognitive-functioning-in-patients-with-autism
#8
B N Anil Kumar, Savita Malhotra, Anish Bhattacharya, Sandeep Grover, Y K Batra
INTRODUCTION: In spite of three decades of neuroimaging, we are unable to find consistent and coherent anatomical or pathophysiological basis for autism as changes are subtle and there are no studies from India. AIM: To study the regional cerebral glucose metabolism in children with autism using positron emission tomography (PET) scan and to study the behavior and cognitive functioning among them. MATERIALS AND METHODS: Ten subjects (8-19 years) meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for autism were evaluated on Childhood Autism Rating Scale (CARS), trail making test (TMT) A and B, Wisconsin card sorting test, Raven's progressive matrices, and PET scan...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28602012/plasma-levels-of-soluble-amyloid-precursor-protein-%C3%AE-in-symptomatic-alzheimer-s-disease
#9
Panagiotis Alexopoulos, Lena-Sophie Gleixner, Lukas Werle, Felix Buhl, Nathalie Thierjung, Evangelia Giourou, Simone M Kagerbauer, Philippos Gourzis, Hubert Kübler, Timo Grimmer, Igor Yakushev, Jan Martin, Alexander Kurz, Robert Perneczky
The established biomarkers of Alzheimer's disease (AD) require invasive endeavours or presuppose sophisticated technical equipment. Consequently, new biomarkers are needed. Here, we report that plasma levels of soluble amyloid precursor protein β (sAPPβ), a protein of the initial phase of the amyloid cascade, were significantly lower in patients with symptomatic AD (21 with mild cognitive impairment due to AD and 44 with AD dementia) with AD-typical cerebral hypometabolic pattern compared with 27 cognitively healthy elderly individuals without preclinical AD...
June 10, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28601897/histone-methylation-in-the-freeze-tolerant-wood-frog-rana-sylvatica
#10
Liam J Hawkins, Kenneth B Storey
Freeze-tolerant animals survive sub-zero temperatures and long-term starvation associated with the winter by lowering their metabolic rate using a variety of transcriptional, translational, and post-translational regulatory methods. Histone methylation is one mechanism that is known to regulate gene expression at the transcriptional level. Here, we measured relative protein levels of seven histone methyltransferases (SMYD2, SETD7, ASH2L, RBBP5, SUV39H1, EHMT2, and SET8), four methylated histone H3 residues (H3K4me1, H3K9me3, H3K27me1, and H3K36me2), the methyltransferase activity on H3K4, and methylation of p53 (p53K370me2 and p53K372me1) in the skeletal muscle and liver of the freeze-tolerant wood frog (Rana sylvatica) during the freeze-thaw cycle...
June 10, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28600444/deconstructing-psychosis-and-misperception-symptoms-in-parkinson-s-disease
#11
Yoshiyuki Nishio, Kayoko Yokoi, Makoto Uchiyama, Yasuyuki Mamiya, Hiroyuki Watanabe, Miyeong Gang, Toru Baba, Atsushi Takeda, Kazumi Hirayama, Etsuro Mori
OBJECTIVE: Patients with Lewy body disease develop a variety of psychotic and misperception symptoms, including visual hallucinations and delusions, as well as 'minor hallucinations', that is, a sense of presence, passage hallucinations and visual illusions. Although these symptoms have been suggested to have common underlying mechanisms, the commonalities and differences among them have not been systematically investigated at the neural level. METHODS: Sixty-seven patients with Parkinson's disease underwent neuropsychological and behavioural assessments, volumetric MRI and 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET)...
June 9, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28595975/brain-molecular-imaging-in-pharmacoresistant-focal-epilepsy-current-practice-and-perspectives
#12
A Verger, S Lagarde, L Maillard, F Bartolomei, E Guedj
This review aims to synthesize all the available data on brain molecular imaging, such as single-photon emission computed tomography (SPECT) and interictal fluorodeoxyglucose positron emission tomography (FDG-PET), in focal epilepsies. SPECT imaging is able to measure regional cerebral blood flow and its major innovation remains its ictal imaging value. On the other hand, FDG-PET, which has higher spatial resolution and lower background activity than SPECT, enables glycolytic metabolism to be identified in interictal states...
June 5, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28592043/-a-report-of-atypical-hypomyelinating-leukodystrophy-with-atrophy-of-the-basal-ganglia-and-cerebellum-caused-by-a-de-novo-mutation-in-tubulin-beta-4a-tubb4a-gene-and-literature-review
#13
Y Du, C Li, J Guo, P Guo, Z Y Li, W Zhang
Objective: To explore the clinical symptoms and neuroimaging features of a patient with atypical hypomyelinating leukodystrophy with atrophy of the basal ganglia and cerebellum (H-ABC) caused by a novel TUBB4A mutation. Methods: We analyzed the clinical data, imaging features and the result of genetic testing of a case diagnosed as atypical H-ABC. Results: The initial symptoms were progressive spasticity, mild cerebellar ataxia and mild cognitive impairment. MRI showed regional blurring of slight high signal on T(2)-weight and FLAIR image in white matter of the bilateral midbrain ventral, internal capsule, posteior horn of lateral ventricle and centrum semiovale, with normal bilateral cerebellar and caudoputamen nucleus...
June 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28591477/reduced-glucose-metabolism-in-neocortical-network-nodes-remote-from-hypothalamic-hamartomas-reflects-cognitive-impairment
#14
Kathrin Wagner, Andreas Schulze-Bonhage, Horst Urbach, Michael Trippel, Timo S Spehl, Franziska Buschmann, Birgitta Metternich, Isabell Ofer, Philipp T Meyer, Lars Frings
The clinical appearance of patients with hypothalamic hamartomas is very heterogeneous, and interindividual variability of intellectual abilities is not completely understood. We retrospectively investigated cerebral dysfunction as indicated by reduced regional glucose metabolism in 29 patients (age range 7-49 years) with epilepsy due to hypothalamic hamartomas. Brain metabolism assessed by [(18) F]FDG-PET was compared between patients with and without cognitive impairment controlled for unevenly distributed hamartoma lateralization seen on magnetic resonance imaging (MRI)...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28579482/precuneus-degeneration-and-isolated-apathy-in-patients-with-parkinson-s-disease
#15
Jung Hwan Shin, Seong A Shin, Jee-Young Lee, Hyunwoo Nam, Jae-Sung Lim, Yu Kyeong Kim
INTRODUCTION: To investigate isolated apathy in a set of consecutively enrolled Parkinson's disease (PD) patients without dementia, depression, and significant motor response fluctuations, by conducting neuropsychological and neuroimaging analyses. METHODS: One hundred twenty-four patients were eligible for inclusion in this study. Clinical information and data were collected from a predefined neuropsychological test battery, including the mini-mental status examination, apathy scale, geriatric depression scale, digit span test, Boston naming test, Seoul verbal learning test, controlled oral word association test, go-no-go test, and the Rey figure copy test...
June 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28575149/cerebrovascular-resistance-effects-on-cognitive-decline-cortical-atrophy-and-progression-to-dementia
#16
Belinda Yew, Daniel A Nation
Evidence for vascular contributions to Alzheimer's disease has been increasingly identified, with increased blood pressure and decreased cerebral blood flow both linked to in vivo biomarkers and clinical progression of Alzheimer's disease. We therefore hypothesized that an elevated ratio of blood pressure to cerebral blood flow, indicative of cerebrovascular resistance, would exhibit earlier and more widespread associations with Alzheimer's disease than cerebral blood flow alone. Further, we predicted that increased cerebrovascular resistance and amyloid retention would synergistically influence cognitive performance trajectories, independent of neuronal metabolism...
June 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28574155/a-systematic-review-of-neuroimaging-in-delirium-predictors-correlates-and-consequences
#17
Anita Nitchingham, Varun Kumar, Susan Shenkin, Karen J Ferguson, Gideon A Caplan
OBJECTIVE: Neuroimaging advances our understanding of delirium pathophysiology and its consequences. A previous systematic review identified 12 studies (total participants N = 764, delirium cases N = 194; years 1989-2007) and found associations with white matter hyperintensities (WMH) and cerebral atrophy. Our objectives were to perform an updated systematic review of neuroimaging studies in delirium published since January 2006 and summarise the available literature on predictors, correlates or outcomes...
June 2, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28567435/abnormal-brain-metabolism-on-fdg-pet-ct-is-a-common-early-finding-in-autoimmune-encephalitis
#18
John C Probasco, Lilja Solnes, Abhinav Nalluri, Jesse Cohen, Krystyna M Jones, Elcin Zan, Mehrbod S Javadi, Arun Venkatesan
OBJECTIVE: To compare the rate of abnormal brain metabolism by FDG-PET/CT to other paraclinical findings and to describe brain metabolism patterns in autoimmune encephalitis (AE). METHODS: A retrospective review of clinical data and initial dedicated brain FDG-PET/CT studies for neurology inpatients with AE, per consensus criteria, treated at a single tertiary center over 123 months. Z-score maps of FDG-PET/CT were made using 3-dimensional stereotactic surface projections with comparison to age group-matched controls...
July 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28566162/brain-positron-emission-tomography-in-patients-with-myotonic-dystrophy-type-1-and-type-2
#19
Stojan Peric, Leposava Brajkovic, Bozidar Belanovic, Vera Ilic, Biljana Salak-Djokic, Ivana Basta, Vidosava Rakocevic Stojanovic
AIM: To determine regions of reduced brain metabolism in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) using 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET), and to analyse their potential association with cognitive deficit. METHOD: Study included 29 patients (16 DM1 and 13 DM2). FDG-PET and detailed neuropsychological testing were performed in both groups. RESULTS: The most common cognitive findings were executive, visuospatial, and naming dysfunction in DM1, and executive and naming dysfunction in DM2...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28561534/gender-differences-in-healthy-aging-and-alzheimer-s-dementia-a-18-f-fdg-pet-study-of-brain-and-cognitive-reserve
#20
Maura Malpetti, Tommaso Ballarini, Luca Presotto, Valentina Garibotto, Marco Tettamanti, Daniela Perani
Cognitive reserve (CR) and brain reserve (BR) are protective factors against age-associated cognitive decline and neurodegenerative disorders. Very limited evidence exists about gender effects on brain aging and on the effect of CR on brain modulation in healthy aging and Alzheimer's Dementia (AD). We investigated gender differences in brain metabolic activity and resting-state network connectivity, as measured by (18) F-FDG-PET, in healthy aging and AD, also considering the effects of education and occupation...
May 31, 2017: Human Brain Mapping
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