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Blood componant transfusion

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https://www.readbyqxmd.com/read/29022123/assessment-of-a-closed-wash-system-developed-for-processing-living-donor-femoral-heads
#1
M J Eagle, J Man, P Rooney, T A McQuillan, G Galea, J N Kearney
NHS Blood and Transplant Tissue and Eye Services (TES) and Scottish National Blood Transfusion Services Tissues and Cells Directorate (TCD) currently bank whole, frozen femoral head bone from living donors who are undergoing primary hip replacement surgery. When required, the bone is issued to a surgeon still frozen on dry ice (- 79 °C). Consequently, the femoral head bone is not processed, is not sterilised and at the time of issue, it contains donor blood, bone marrow and associated cells. We have previously shown that, cut, shaped and washed bone from deceased donors can be processed to remove up to 99...
October 11, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29017820/possible-utility-of-the-basophil-activation-test-for-the-analysis-of-mechanisms-involved-in-allergic-transfusion-reactions
#2
REVIEW
Fumiya Hirayama, Kazuta Yasui, Nobuki Matsuyama, Ikue Okamura-Shiki
Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they have not been well studied. One of the reasons for this may be the absence of a standard assay system for investigating these processes. Basophils and/or mast cells are key effector cells in immediate-type allergic reactions...
September 19, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28990242/blood-utilization-in-revision-versus-first-time-cardiac-surgery-an-update-in-the-era-of-patient-blood-management
#3
Nadia B Hensley, Megan P Kostibas, William W Yang, Todd C Crawford, Kaushik Mandal, Pranjal B Gupta, Steven M Frank, Charles H Brown
BACKGROUND: Relative to first-time (primary) cardiac surgery, revision cardiac surgery is associated with increased transfusion requirements, but studies comparing these cohorts were performed before patient blood management (PBM) and blood conservation measures were commonplace. The current study was performed as an update to determine if this finding is still evident in the PBM era. STUDY DESIGN AND METHODS: Primary and revision cardiac surgery cases were compared in a retrospective database analysis at a single tertiary care referral center...
October 8, 2017: Transfusion
https://www.readbyqxmd.com/read/28970693/acute-respiratory-distress-syndrome-in-a-neonate-due-to-possible-transfusion-related-acute-lung-injury
#4
Arti Maria, Sheetal Agarwal, Anu Sharma
Transfusion-related acute lung injury (TRALI) is a potentially life-threatening complication of blood component transfusion. It is relatively underdiagnosed entity in neonates with scant literature. We report a case of TRALI in a preterm neonate developing acute respiratory distress within 6 h of blood product transfusion in the absence of preexisting lung disease. Prompt ventilator and supportive management were instituted. The baby showed clinical and radiological improvement within 12 h; however, he succumbed to death due to acute massive pulmonary hemorrhage 36 h later...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28970688/transfusion-related-adverse-reactions-in-pediatric-and-surgical-patients-at-a-tertiary-care-teaching-hospital-in-india
#5
Kunal J Ghataliya, Jigar D Kapadia, Mira K Desai, K M Mehariya, G H Rathod, Nidhi Bhatnagar, M D Gajjar
BACKGROUND: Use of blood and its components is lifesaving. However, their use is often associated with adverse events. OBJECTIVE: To analyze the pattern of adverse reactions associated with transfusion of blood and its components in pediatric and surgical patients at a tertiary care teaching hospital. MATERIALS AND METHODS: Patients receiving transfusion of blood or its components in a randomly selected unit each from Departments of Pediatrics, including thalassemia OPD and surgery, were monitored intensively for a period of 6 months...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28970679/dedicated-donor-unit-transfusions-reduces-donor-exposure-in-pediatric-surgery-patients
#6
Satyam Arora, Neelam Marwaha, Hari Krishan Dhawan, K L N Rao
BACKGROUND: Many strategies have been explored to reduce multiple donor exposures in neonates such as use of restrictive transfusion protocols, limiting iatrogenic blood loss, use of recombinant erythropoietin and single donor programs. METHOD: In our study we assessed the feasibility of dedicating single donor units with reserving all the components from the same donor for the specified neonates/infants undergoing surgery and estimating reduction of donor exposure...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28968013/detection-of-trypanosoma-cruzi-antibodies-in-multitransfused-patients-in-colombia
#7
Mauricio Beltrán, Andrea Herrera, Astrid Carolina Flórez, Maritza Berrio, María Isabel Bermúdez
INTRODUCTION: Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation. OBJECTIVE: To describe the prevalence of T. cruzi infection in multitransfused patients. MATERIALS AND METHODS: We detected IgG antibodies against T. cruzi by two immunoassays in samples from multitransfused patients in four hospitals located in Bogotá and Medellín, Colombia...
September 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28963906/abo-identical-and-washed-blood-transfusions-as-candidate-strategies-to-reduce-early-mortality-in-acute-promyelocytic-leukemia
#8
Tanmay Sahai, Kelly Henrichs, Majed Refaai, Joanna M Heal, Scott A Kirkley, Amy E Schmidt, Jason H Mendler, Debra Masel, Jane Liesveld, Christopher Aquina, Neil Blumberg
BACKGROUND: Despite dramatically improved long term outcomes seen with all-trans retinoic acid therapy, and now arsenic trioxide, in acute promyelocytic leukemia (APL), early mortality remains a substantial challenge. Recent data from a single center study and the Surveillance, Epidemiology and End Results (SEER) registry report 30day mortality rates of 26% (n=18 of 70) and 17% (n=238 of 1400), respectively. Early deaths are predominately due to hemorrhage. Patients with APL invariably have abnormal laboratory hemostasis tests...
September 23, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28960337/reconsideration-of-blood-donation-testing-strategy-for-human-t-cell-lymphotropic-virus-in-australia
#9
C E Styles, C R Seed, V C Hoad, S Gaudieri, A J Keller
BACKGROUND AND OBJECTIVES: Universal testing of blood donations for human T-cell lymphotropic virus (HTLV) in Australia may no longer be appropriate given the low prevalence of HTLV infection and the mitigating effect of universal leucodepletion for cellular components. This study aimed to determine the most appropriate HTLV testing strategy using the Risk-Based Decision-Making Framework for Blood Safety. MATERIALS AND METHODS: The risk of HTLV transfusion-transmission using three testing strategies (universal, new-donor and no testing) and cost-effectiveness of the first two strategies were assessed using adaptations of published mathematical models...
September 27, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28952159/bacterial-testing-of-platelets-has-it-prevented-transfusion-transmitted-bacterial-infections-in-australia
#10
J Thyer, Z Perkowska-Guse, S L Ismay, A J Keller, H T Chan, P M Dennington, B Bell, G Kotsiou, J M Pink
BACKGROUND AND OBJECTIVES: Australia introduced bacterial contamination screening (BCS) for platelet components in April 2008. This study presents analysis performed to assess the efficacy of testing. MATERIALS AND METHODS: Seven-day aerobic and anaerobic culture is performed using the BacT/ALERT 3D system. Following an initial machine positive (IMP) flag, all associated components are recalled, and/or clinicians treating already transfused patients are notified...
September 26, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28951054/recent-trends-in-blood-utilization-after-revision-hip-and-knee-arthroplasty
#11
Robert A Burnett, Nicholas A Bedard, David E DeMik, Yubo Gao, Steve S Liu, John J Callaghan
BACKGROUND: Blood transfusion guidelines in elective surgery have been implemented over the last decade to minimize risk and cost related to transfusion without sacrificing patient outcomes. Blood utilization in primary total hip (THA) and total knee arthroplasty (TKA) has been extensively studied but there is a paucity of studies evaluating utilization in revision THA and TKA. The purpose of this study is to evaluate current trends in transfusion following revision THA and TKA. METHODS: The Humana dataset was reviewed for transfusion trends from 2007 to 2015 for patients undergoing revision THA and TKA...
September 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28948619/analysis-of-pediatric-adverse-reactions-to-transfusions
#12
Sarah Vossoughi, Gabriela Perez, Barbee I Whitaker, Mark K Fung, Brie Stotler
BACKGROUND: Children are known to be physiologically and biochemically different from adults. However, there are no multi-institutional studies examining the differences in the frequency, type, and severity of transfusion reactions in pediatric versus adult patients. This study aims to characterize differences between pediatric and adult patients regarding adverse responses to transfusions. STUDY DESIGN AND METHODS: This is a retrospective data analysis of nine children's hospitals and 35 adult hospitals from January 2009 through December 2015...
September 25, 2017: Transfusion
https://www.readbyqxmd.com/read/28948604/transfusion-related-acute-lung-injury-risk-mitigation-an-update
#13
REVIEW
Z K Otrock, C Liu, B J Grossman
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of transfusion. Greater understanding of the pathophysiology of this syndrome has much improved during the last two decades. Plasma-containing components from female donors with leucocyte antibodies were responsible for the majority of TRALI fatalities before mitigation strategies were implemented. Over the past 15 years, measures to mitigate risk for TRALI have been implemented worldwide and they continued to evolve with time...
September 25, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28944508/blood-service-in-the-tibetan-regions-of-garz%C3%A3%C2%AA-and-aba-china-a-longitudinal-survey
#14
Y Wang, Z Wu, Y H Yin, S Q Rao, B Liu, X Q Huang, X X Liu, W H Li, S L Ye, S Y Li, X C Yu, D R Wu, J Xu, Z K Wang, R Zhang, C Q Li
BACKGROUND: Garzê and Aba form the second largest Tibetan-inhabited area of China. Blood services have never been reported for this region before. OBJECTIVE: To assess the current situation and analyse whether a safe and adequate blood supply has been developed in both Garzê and Aba. METHODS: We conducted a longitudinal survey covering the period 2011-2016. The subjects of interest were recruited from non-remunerated voluntary donation, blood testing, clinical transfusion practices and infrastructure of local blood service systems...
September 25, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28938306/different-clinical-course-and-complications-in-interagency-registry-for-mechanically-assisted-circulatory-support-1-patients-managed-with-or-without-extracorporeal-membrane-oxygenation
#15
Jason J Han, Jennifer Chung, Carol W Chen, Ann C Gaffey, Alex Sotolongo, Christyna Justice, Alyse E Ameer, J Eduardo Rame, Christian Bermudez, Michael A Acker, Pavan Atluri
Extracorporeal membrane oxygenation (ECMO) as a bridge to left ventricular assist device (LVAD) implantation has shown promise in improving end-organ function and optimizing outcomes in some critically ill patients, but the practice remains controversial. Retrospective review of patients who received LVADs from May 2008 to September 2016 at a high-volume, tertiary care cardiovascular center was performed. Subjects were Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) class 1 patients divided into ECMO bridge and non-ECMO bridge cohorts...
September 21, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28934519/intra-pericardial-use-of-recombinant-factor-viia-in-a-patient-with-acute-hemorrhagic-pericardial-effusion-following-transcutaneous-aortic-valve-replacement-a-case-report
#16
Vanya Jaitly, Kimberly Klein, Hlaing Tint, Alice Chen, Paul Allison, Bindu Akkanti, Pranav Loyalka, Brian Castillo
Perioperative bleeding can be a serious life-threatening complication in adult patients undergoing cardiac surgery, given the older age and additional comorbidities present in this patient population. The standard treatment options include transfusion of blood components and surgical re-exploration. We report the first case of an elderly female patient treated with local administration of recombinant factor VIIa (rFVIIa) for intractable hemorrhagic pericardial effusion, which developed following a transcutaneous aortic valve replacement (TAVR) procedure for severe aortic stenosis...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28924429/administration-safety-of-blood-products-lessons-learned-from-a-national-registry-for-transfusion-and-hemotherapy-practice
#17
Thomas Frietsch, Daffyd Thomas, Michael Schöler, Birgit Fleiter, Martin Schipplick, Michael Spannagl, Ralf Knels, Xuan Nguyen
BACKGROUND: Compared to blood component safety, the administration of blood may not be as safe as intended. The German Interdisciplinary Task Force for Clinical Hemotherapy (IAKH) specialized registry for administration errors of blood products was chosen for a detailed analysis of reports. METHODS: Voluntarily submitted critical incident reports (n = 138) from 2009 to 2013 were analyzed. RESULTS: Incidents occurred in the operation room (34...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28921542/pathogen-inactivation-of-dengue-virus-in-red-blood-cells-using-amustaline-and-glutathione
#18
Maite Aubry, Andrew Laughhunn, Felicia Santa Maria, Marion C Lanteri, Adonis Stassinopoulos, Didier Musso
BACKGROUND: Dengue virus (DENV) is an arbovirus primarily transmitted through mosquito bite; however, DENV transfusion-transmitted infections (TTIs) have been reported and asymptomatic DENV RNA-positive blood donors have been identified in endemic countries. DENV is considered a high-risk pathogen for blood safety. One of the mitigation strategies to prevent arbovirus TTIs is pathogen inactivation. In this study we demonstrate that the amustaline and glutathione (S-303/GSH) treatment previously found effective against Zika virus in red blood cells (RBCs) is also effective in inactivating DENV...
September 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28913908/provision-of-cellular-blood-components-to-cmv-seronegative-patients-undergoing-allogeneic-stem-cell-transplantation-in-the-uk-survey-of-uk-transplant-centres
#19
S Morton, A Peniket, R Malladi, M F Murphy
OBJECTIVES: To identify current UK practice with regards to provision of blood components for cytomegalovirus (CMV)-seronegative, potential, allogeneic stem cell recipients of seronegative grafts. BACKGROUND: Infection with CMV remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT). CMV transmission has been a risk associated with the transfusion of blood components from previously exposed donors, but leucocyte reduction has been demonstrated to minimise this risk...
September 15, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28899856/release-of-the-tourniquet-immediately-after-the-implantation-of-the-components-reduces-the-incidence-of-deep-vein-thrombosis-after-primary-total-knee-arthroplasty
#20
P Zan, M O Mol, J J Yao, L Fan, D Yang, K Liu, G Li
AIMS: The length of the tourniquet time during total knee arthroplasty (TKA) is related to the incidence of post-operative deep vein thrombosis (DVT). Our aim in this study was to investigate the effect of the early release of the tourniquet on the incidence of DVT in patients undergoing TKA. METHODS: A total of 200 patients who underwent TKA between November 2015 and November 2016 were prospectively enrolled. The tourniquet was inflated before surgery and released immediately after the introduction of the components (early release group)...
September 2017: Bone & Joint Research
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