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Blood componant transfusion

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https://www.readbyqxmd.com/read/29669792/transfusion-transmitted-infections-an-update-on-product-screening-diagnostic-techniques-and-the-path-ahead
#1
Christina L Dean, Jenna Wade, John D Roback
The first mandated testing of blood components for infectious diseases began in the 1950s to prevent transfusion-transmitted infections (TTI). Since then, changes in pre-donation questionnaires and advances in testing techniques have afforded more sensitive and specific tests for pathogens in addition to allowing for earlier detection. Given that these approaches have very low but detectable failure rates, recent development and implementation of pro-active pathogen reduction approaches is the new forefront of TTI prevention strategies...
April 18, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29666112/increased-erythrophagocytosis-induces-ferroptosis-in-red-pulp-macrophages-in-a-mouse-model-of-transfusion
#2
Lyla A Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P Weisberg, Brent R Stockwell, Eldad A Hod, Steven L Spitalnik
Macrophages play important roles in recycling iron derived from the clearance of red blood cells (RBCs). They are also a critically important component of host defense, protecting against invading pathogens. However, the effects on macrophage biology of acutely ingesting large numbers of RBCs are not completely understood. To investigate this issue, we used a mouse model of RBC transfusion and clearance, which mimics the clinical setting. In this model, transfusions of refrigerator storage-damaged (i.e., "old") RBCs led to increased erythrophagocytosis by splenic red pulp macrophages (RPMs)...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29664127/cell-free-nucleic-acids-are-present-in-blood-products-and-regulate-genes-of-innate-immune-response
#3
Sophie Waldvogel Abramowski, Diderik Tirefort, Pierre Lau, Arthur Guichebaron, Sofiane Taleb, Christine Modoux, Coralie Lemoine Chaduc, Pascale Bruyere Cerdan, Pascale Roux Lombard, Thomas Lecompte, Olivier Preynat-Seauve
BACKGROUND: Extracellular nucleic acids circulate in plasma. They are expected to be present in manufactured blood products eligible for transfusion, but little is known about their biological activity on human cells. The aim of this study is to investigate whether cell-free nucleic acids (CFNAs) are present and biologically active in red blood cell units (RBCUs), fresh frozen plasmas, and platelet concentrates. STUDY DESIGN AND METHODS: CFNAs were extracted from RBCUs, fresh frozen plasma, and platelet concentrates...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29661680/individual-level-key-associations-and-modes-of-exposure-for-hepatitis-c-virus-infection-in-the-middle-east-and-north-africa-a-systematic-synthesis
#4
Sarwat Mahmud, Silva P Kouyoumjian, Zaina Al Kanaani, Hiam Chemaitelly, Laith J Abu-Raddad
PURPOSE: To identify, map, and synthesize the individual-level key associations and modes of exposure for hepatitis C virus (HCV) infection in the Middle East and North Africa (MENA), the most affected region by HCV. METHODS: Source of data was the MENA HCV Epidemiology Synthesis Project database, populated through systematic literature searches. Risk factors determined to be statistically significant after adjustment for confounders were extracted and categorized into key associations or modes of exposure...
March 21, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29652280/relationship-between-maximum-clot-firmness-in-rotem-%C3%A2-and-postoperative-bleeding-after-coronary-artery-bypass-graft-surgery-in-patients-using-clopidogrel
#5
Rasoul Azarfarin, Fereidoon Noohi, Majid Kiavar, Ziae Totonchi, Avaz Heidarpour, Amir Hendiani, Zahra Sadat Koleini, Saeid Rahimi
Background: The aim of the present study was to investigate the relationship between maximum clot firmness (MCF) in rotational thromboelastometry (ROTEM® ) and postoperative bleeding in patients on clopidogrel after emergency coronary artery bypass graft surgery (CABG). Methods: This observational study recruited 60 patients posted for emergency CABG following unsuccessful primary percutaneous coronary intervention (PCI) while on 600 mg of clopidogrel. The study population was divided into 2 groups on the basis of their MCF in the extrinsically activated thromboelastometric (EXTEM) component of the (preoperative) ROTEM® test: patients with MCF <50 mm (n = 16) and those with MCF ≥50 mm (n = 44)...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29649026/evidence-review-conducted-for-the-agency-for-healthcare-research-and-quality-safety-program-for-improving-surgical-care-and-recovery-focus-on-anesthesiology-for-colorectal-surgery
#6
Kristen A Ban, Melinda M Gibbons, Clifford Y Ko, Elizabeth C Wick, Maxime Cannesson, Michael J Scott, Michael C Grant, Christopher L Wu
The Agency for Healthcare Research and Quality, in partnership with the American College of Surgeons and the Johns Hopkins Medicine Armstrong Institute for Patient Safety and Quality, has developed the Safety Program for Improving Surgical Care and Recovery (ISCR), which is a national effort to disseminate best practices in perioperative care to more than 750 hospitals across multiple procedures in the next 5 years. The program will integrate evidence-based processes central to enhanced recovery and prevention of surgical site infection, venous thromboembolic events, catheter-associated urinary tract infections with socioadaptive interventions to improve surgical outcomes, patient experience, and perioperative safety culture...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29627883/platelet-transfusion-increases-risk-for-acute-respiratory-distress-syndrome-in-non-massively-transfused-blunt-trauma-patients
#7
George Kasotakis, Nichole Starr, Erek Nelson, Bedabrata Sarkar, Peter Ashley Burke, Daniel George Remick, Ronald Gary Tompkins
PURPOSE: While damage control resuscitation is known to confer a survival advantage in severely injured patients, high-ratio blood component therapy should be initiated only in carefully selected trauma patients, due to the morbidity associated with blood product use. With this project, we aim to identify the effect of platelet transfusion in non-massively transfused bluntly injured patients. METHODS: The Glue Grant database was retrospectively queried and severely injured blunt trauma patients who underwent non-massive transfusion were identified...
April 7, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29626699/therapeutics-incorporating-blood-constituents
#8
REVIEW
Phapanin Charoenphol, Katie Oswalt, Corey J Bishop
Blood deficiency and dysfunctionality can result in adverse events, which can primarily be treated by transfusion of blood or the re-introduction of properly functioning sub-components. Blood constituents can be engineered on the sub-cellular (i.e., DNA recombinant technology) and cellular level (i.e., cellular hitchhiking for drug delivery) for supplementing and enhancing therapeutic efficacy, in addition to rectifying dysfunctioning mechanisms (i.e., clotting). Herein, we report the progress of blood-based therapeutics, with an emphasis on recent applications of blood transfusion, blood cell-based therapies and biomimetic carriers...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29624755/searching-for-unknown-transfusion-transmitted-hepatitis-viruses-a-bi-national-cohort-study-of-1-5-million-transfused-patients
#9
Gustaf Edgren, Henrik Hjalgrim, Klaus Rostgaard, Viktor Dahl, Kjell Titlestad, Christian Erikstrup, Agneta Wikman, Rut Norda, Ammar Majeed
BACKGROUND: Both hepatitis B and C viruses were transmitted through blood transfusion before implementation of donor screening. The existence of additional, yet unknown transfusion transmittable agents causing liver disease could have important public health implications. METHODS: Analyses were based on the Scandinavian Donations and Transfusions (SCANDAT2) database. Cox regression models were used to estimate the hazard ratio (HR) of developing chronic liver disease in recipients of blood from donors who later developed any chronic liver disease compared to recipients who received blood transfusion from healthy donors...
April 6, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29608320/a-brief-overview-of-clinical-significance-of-blood-group-antibodies
#10
Manish J Gandhi, D M Strong, Barbee I Whitaker, Evangelia Petrisli
This review was derived from a presentation made on September 2, 2016 for the first Academy Day presented by the Working Party on Immunohematology at the International Society of Blood Transfusion (ISBT) Congress in Dubai. The focus of this review is to provide a brief overview of the clinical significance of blood group antibodies. Blood group antibodies can be naturally occurring (e.g., anti-A and anti-B through exposure to naturally occurring red blood cell [RBC] antigen-like substances) or can occur via exposure to foreign (donor) RBC antigens through previous transfusions, transplants, or exposure to fetal RBCs during or after pregnancy...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29607859/challenges-in-the-management-of-bleeding-disorders-in-nigeria
#11
H C Okoye, K I Korubo, B Nwogoh, C C Efobi, N I Ugwu, A J Madu
Background: Bleeding disorders (BDs) are characterized by abnormal bleeding for which effective management requires a combination of skill, workforce, diagnostic facilities, and adequate therapeutic options. Objectives: The objectives of this study were to determine the capacity of Nigerian hematologists to handle BDs and to assess availability of required infrastructure, equipment, and treatment options. Materials and Methods: This descriptive study was conducted during the 2016 scientific conference of the Nigerian Society for Hemetology and Blood Transfusion...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29607593/massive-transfusions-for-critical-bleeding-is-everything-old-new-again
#12
REVIEW
A W J Flint, Z K McQuilten, E M Wood
Massive transfusion or major haemorrhage protocols have been widely adopted in the treatment of critically bleeding patients. Following evidence that higher ratios of transfused plasma and platelets to red blood cells may offer survival benefits in military trauma patients, these ratios are now commonly incorporated into massive transfusion protocols. They more closely resemble the effects of whole blood transfusion, which in the second half of last century was largely replaced by individual blood component transfusion based on laboratory-guided indicators...
April 1, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29607502/amotosalen-uva-treatment-inactivates-t-cells-more-effectively-than-the-recommended-gamma-dose-for-prevention-of-transfusion-associated-graft-versus-host-disease
#13
Grace Castro, Patricia A Merkel, Hannah E Giclas, Andrew Gibula, Gillian E Andersen, Laurence M Corash, Jin Sying Lin, Jennifer Green, Vijaya Knight, Adonis Stassinopoulos
INTRODUCTION: Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication after transfusion of components containing viable donor T cells. Gamma irradiation with doses that stop T-cell proliferation is the predominant method to prevent TA-GVHD. Treatment with pathogen inactivation methodologies has been found to also be effective against proliferating white blood cells, including T cells. In this study, T-cell inactivation was compared, between amotosalen/ultraviolet A (UVA) treatment and gamma-irradiation (2500 cGy), using a sensitive limiting dilution assay (LDA) with an enhanced dynamic range...
April 2, 2018: Transfusion
https://www.readbyqxmd.com/read/29607473/emergency-blood-transfusion-in-children-in-a-tertiary-hospital-in-nigeria-indications-frequency-and-outcome
#14
B I Abhulimhen-Iyoha, Y T Israel-Aina
BACKGROUND: Blood transfusion is a life-saving procedure in paediatric practice. It is important in replacing blood volume in cases of haemorrhage or providing specific blood components as required. However, the procedure carries some risks and complications. The decision to transfuse, frequency of transfusion and the availability of safe blood and blood products are essential determinants of the success of the procedure. Hence, knowledge of the indications and rate of transfusion is important to ensure that blood for transfusion is safe and made available as at when due...
January 2018: West African Journal of Medicine
https://www.readbyqxmd.com/read/29605431/combination-of-blood-lactate-level-with-assessment-of-blood-consumption-abc-scoring-system-a-more-accurate-predictor-of-massive-transfusion-requirement
#15
Wongsakorn Chaochankit, Osaree Akaraborworn, Burapat Sangthong, Komet Thongkhao
PURPOSE: Exsanguination is the most common leading cause of death in trauma patients. The massive transfusion (MT) protocol may influence therapeutic strategies and help provide blood components in timely manner. The assessment of blood consumption (ABC) score is a popular MT protocol but has low predictability. The lactate level is a good parameter to reflect poor tissue perfusion or shock states that can guide the management. This study aimed to modify the ABC scoring system by adding the lactate level for better prediction of MT...
March 3, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29602707/neutrophil-extracellular-traps-were-released-during-intraoperative-blood-salvage-in-posterior-lumbar-surgery
#16
Li Zheng, Ming Tian, Ye Zhang, Peng Dong, He Yang
The formation of neutrophil extracellular traps (NETs) has been associated with endothelial damage and severe pulmonary dysfunction. The present study aimed to investigate whether this NETosis occurs during intraoperative blood salvage (IBS), and whether the washing procedures before re-transfusion of autologous blood could remove the NET components, including DNA, histones, and myeloperoxidase. The study was performed using blood samples from 20 patients who underwent posterior lumbar surgery at the Beijing Friendship Hospital...
March 14, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29599628/analysis-of-acute-transfusion-reactions-and-their-occurrence-times
#17
Yuki Hatayama, Satoko Matsumoto, Eiko Hamada, Nao Kojima, Ayako Hara, Norihiko Hino, Toru Motokura
Acute transfusion reactions (ATRs) are significantly relevant to the morbidity and mortality of patients. ATRs are mostly not severe and rarely cause severe conditions, including anaphylactic shock. The aim of this study was to clarify the frequency of ATRs and the time of event occurrence. A total of 18,745 transfusions were administered to 11,718 patients during a 3-year period. Adverse reactions including at least one sign or symptom were collected through a report system in 143 of 2,478 (5.7%) platelet concentrate transfusions, 105 of 6,629 (1...
March 2018: Yonago Acta Medica
https://www.readbyqxmd.com/read/29570817/red-blood-cell-alloimmunization-in-sickle-cell-disease-assessment-of-transfusion-protocols-during-two-time-periods
#18
Sally A Campbell-Lee, Kristina Gvozdjan, K Mia Choi, Yi-Fan Chen, Santosh L Saraf, Lewis L Hsu, Victor R Gordeuk, Ronald G Strauss, Darrell J Triulzi
BACKGROUND: Prevention of red blood cell (RBC) alloimmunization in patients with sickle cell disease (SCD) focuses on phenotypic RBC matching. We assessed alloimmunization among transfused patients with SCD after implementing leukoreduction and prophylactic antigen matching (PAM). STUDY DESIGN AND METHODS: Retrospective review of transfusion and medical records for SCD patients 18 months to 81 years of age was performed covering two 5-year periods: Period 1, no PAM, occasional leukoreduction, and Period 2, consistent leukoreduction and extended PAM (Rh, Kell, S, Fy, Jk) for patients already alloimmunized...
March 23, 2018: Transfusion
https://www.readbyqxmd.com/read/29567027/a-prospective-randomized-study-of-bovine-carotid-artery-biologic-graft-and-expanded-polytetrafluoroethylene-for-permanent-hemodialysis-access
#19
Hanaa Dakour Aridi, Isibor Arhuidese, Melissa Scudder, Thomas Reifsnyder, Mahmoud B Malas
OBJECTIVE: Arteriovenous grafts (AVGs) remain reliable substitutes for permanent hemodialysis access in scenarios that preclude the placement of native arteriovenous fistulas (AVFs). The majority of AVGs are constructed of expanded polytetrafluoroethylene (ePTFE), which is relatively inexpensive and readily available, but synthetic AVGs have poor patency rates. On the other hand, biologic grafts confer an advantage by virtue of their inherent similarity to the native human vasculature...
March 19, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29563673/transfusion-support-in-preterm-neonates-1500-g-and-or-32-weeks-in-a-tertiary-care-center-a-descriptive-study
#20
R A Shanmugha Priya, R Krishnamoorthy, Vinod Kumar Panicker, Binu Ninan
BACKGROUND: Lack of recent studies focusing on indications, pattern, and benefits of transfusions in low birth weight (B.Wt) and low gestational age (GA) preterm neonates prompted us to undertake this study. AIM: To estimate the transfusion requirements and outcomes in preterm neonates <1500 g and/or <32 weeks. SETTINGS AND DESIGN: This is a cross-sectional study conducted over a period of 2 years in a tertiary care center. MATERIALS AND METHODS: This study was conducted with 101 preterm neonates <1500 g and/or <32 weeks who received blood transfusions in the Neonatal Intensive Care Unit...
January 2018: Asian Journal of Transfusion Science
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