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https://www.readbyqxmd.com/read/27922540/prognostic-value-of-quantitative-pet-ct-in-patients-with-a-nonsmall-cell-lung-cancer-and-another-primary-cancer
#1
Xuee Zhu, Chuanhong Liao, Bill C Penney, Feng Li, Mark K Ferguson, Cassie A Simon, Tianming Wu, Haiyan Liu, Yonglin Pu
OBJECTIVE: The staging and management of patients with newly diagnosed nonsmall cell lung cancer (NSCLC) in the setting of recently diagnosed other (metachronous or synchronous) primary cancer are challenging. This retrospective cohort study was carried out to test our hypothesis that baseline 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) PET/CT parameters, including whole-body metabolic tumor volume (MTVWB), total lesion glycolysis (TLGWB), and maximum standardized uptake value (SUVmaxWB), are associated with the overall survival (OS) of such patients...
December 2, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27914779/what-do-radiation-oncologists-require-for-future-advancements-in-lung-sbrt
#2
REVIEW
Umberto Ricardi, Serena Badellino, Andrea Riccardo Filippi
Stereotactic Body Radiotherapy (SBRT) is a well established therapeutic option for patients affected with peripheral early stage non-small cell lung cancer (NSCLC), given the positive clinical evidence accumulated so far on its efficacy and safety. SBRT is regarded as the best choice for inoperable patients, and could also be offered as an alternative to surgery to selected operable patients. More recently, its use for lung metastases progressively increased, and SBRT is now regarded as a low toxic and highly effective local therapy for lung oligometastases from different primary tumors, especially colorectal cancer...
November 30, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27908621/radiotherapy-with-curative-intent-in-patients-with-early-stage-medically-inoperable-non-small-cell-lung-cancer-a-systematic-review
#3
REVIEW
Conrad B Falkson, Emily T Vella, Edward Yu, Medhat El-Mallah, Robert Mackenzie, Peter M Ellis, Yee C Ung
Patients with early-stage non-small-cell lung cancer (NSCLC) who are unable to undergo surgery can be offered radiation therapy (RT). Previously, conventional RT was offered; however, newer techniques such as stereotactic body RT (SBRT) have become available. The objective of the present systematic review was to investigate the effectiveness of RT with curative intent in patients with early-stage medically inoperable NSCLC. MEDLINE, EMBASE, and the Cochrane Library were searched for studies comparing stereotactic RT with curative intent compared with observation or other types of RT for early-stage, medically inoperable, NSCLC...
October 27, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27908619/correlation-of-dna-repair-gene-polymorphisms-with-clinical-outcome-in-patients-with-locally-advanced-non-small-cell-lung-cancer-receiving-induction-chemotherapy-followed-by-surgery
#4
Mariacarmela Santarpia, Jose Luis Ramirez, Itziar de Aguirre, Pilar Garrido, Maria Pérez Cano, Cristina Queralt, Jose Luis Gonzalez-Larriba, Amelia Insa, Mariano Provencio, Dolores Isla, Carlos Camps, Remei Blanco, Teresa Moran, Rafael Rosell
OBJECTIVE: The aim of this study was to evaluate whether xeroderma pigmentosum group D (XPD) and ribonucleotide reductase subunit M1 (RRM1) polymorphisms influenced clinical outcome in patients with stage IIIA-B non-small-cell lung cancer (NSCLC) treated with neoadjuvant gemcitabine/cisplatin/docetaxel followed by surgery. MATERIALS AND METHODS: A total of 109 patients with stage IIIA and IIIB NSCLC were prospectively genotyped to examine a potential association between XPD 312 (aspartic acid [Asp]/asparagine [Asn]), XPD 751 (lysine [Lys]/glutamine [Gln]), and RRM1 (-37 C/A) polymorphisms with response and survival...
November 9, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27903462/radiomic-based-pathological-response-prediction-from-primary-tumors-and-lymph-nodes-in-nsclc
#5
Thibaud P Coroller, Vishesh Agrawal, Elizabeth Huynh, Vivek Narayan, Stephanie W Lee, Raymond H Mak, Hugo J W L Aerts
INTRODUCTION: Non-invasive biomarkers that capture the total tumor burden could provide important complementary information for precision medicine to aid clinical decision-making. We investigated the value of radiomic data, extracted from pre-treatment computed tomography (CT) images of the primary tumor and lymph nodes, in predicting pathological response following neoadjuvant chemoradiation prior to surgery. METHODS: Eighty-five patients with resectable locally-advanced (stage II-III) non-small cell lung cancer (NSCLC) (median age: 60...
November 26, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27900019/the-relationship-between-tumor-volume-changes-and-serial-plasma-osteopontin-detection-during-radical-radiotherapy-of-non-small-cell-lung-cancer
#6
Christian Ostheimer, Franziska Schweyer, Thomas Reese, Matthias Bache, Dirk Vordermark
The prognostic quality of increased osteopontin (OPN) plasma levels has been demonstrated for the chemotherapy and surgery of lung cancer. There is also evidence in the literature that tumor volume impacts prognosis in definitive radiotherapy (RT) of (lung) cancer. We previously demonstrated that elevated plasma levels of OPN before, and increasing OPN plasma levels after RT significantly correlate with survival and outcome after curative-intent RT of non-small-cell lung cancer (NSCLC). Tumor volume was also associated with prognosis...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27897153/isoflurane-promotes-non-small-cell-lung-cancer-malignancy-by-activating-the-akt-mammalian-target-of-rapamycin-mtor-signaling-pathway
#7
Wenhua Zhang, Xueqian Shao
BACKGROUND Lung cancer is one of the leading causes of cancer mortalities worldwide, and non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. Surgery remains one of the front-line treatment options for NSCLC, but events within the perioperative period were found to affect cancer prognosis, such as anesthesia procedures. Isoflurane, a commonly used volatile anesthetic, enhances the malignant potential of renal, prostate, and ovarian cancer cells, but its effects on NSCLC development have not been previously reported...
November 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27890561/role-of-adjuvant-therapy-for-node-negative-lung-cancer-invading-the-chest-wall
#8
Sarah J Gao, Christopher D Corso, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: The present study investigated the effect of adjuvant chemotherapy and radiation on survival among patients undergoing chest wall resection for T3N0 non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Patients with T3N0 NSCLC who underwent chest wall resection were identified in the National Cancer Data Base in 2004 to 2012. The cohort was divided into patients who had received adjuvant chemotherapy, radiation therapy, chemoradiation therapy, or no adjuvant treatment...
October 17, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27885858/a-systematic-review-of-outcomes-following-stereotactic-ablative-radiotherapy-in-the-treatment-of-early-stage-primary-lung-cancer
#9
Patrick Murray, Kevin Franks, Gerard G Hanna
Stereotactic ablative body radiotherapy (SABR) describes a radiotherapy technique where high doses of radiation are precisely delivered to an extra-cranial target within the body, using either a single fraction of radiotherapy or using multiple small number of fractions. SABR has now become the standard of care treatment for patients with early stage NSCLC for whom surgery is not appropriate. This systematic review considers the evidence supporting the use of SABR in early stage NSCLC, reported toxicity rates, the use of SABR in centrally located NSCLC, the use of SABR as salvage therapy following surgery or radiotherapy and future potential drug combinations with SABR...
November 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27884195/lymph-node-ratio-as-a-prognostic-factor-in-patients-with-pathological-n2-non-small-cell-lung-cancer
#10
Masaya Tamura, Isao Matsumoto, Daisuke Saito, Shuhei Yoshida, Munehisa Takata, Hirofumi Takemura
BACKGROUND: The aim of this study was to investigate whether the lymph node ratio (LNR) was associated with the prognosis of patients, who underwent surgery for pathological N2 non-small cell lung cancer (NSCLC). METHODS: A total of 182 patients were diagnosed with pathological N2 disease and underwent complete resection surgeries with systematic lymphadenectomies. We counted the number of positives and removed lymph nodes to calculate a ratio between them (LNR)...
November 25, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27875414/the-influence-of-histologic-subtype-in-predicting-survival-of-lung-cancer-patients-with-spinal-metastases
#11
Naresh Kumar, Kimberly-Anne Tan, Jiong Hao Tan, Aye S Zaw, Hwee Weng Dennis Hey, John Ruiz, Emily Stone
STUDY DESIGN: Retrospective analysis. SUMMARY OF BACKGROUND DATA: Recent advancements in systemic treatment of lung cancer have significantly improved the survival of patients with certain histolopathologic and molecular subtypes. Existing prognostic scores do not account for this and patients with lung cancer spinal metastases are grouped together as poor prognostic candidates, and consequently, some may be inappropriately denied palliative spine surgery. OBJECTIVE: The objective of the study was to study whether the expected survival in patients with lung cancer spinal metastases is affected by histolopathologic and molecular subtypes in the context of modern systemic therapy...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27867563/single-port-video-assisted-thoracic-surgery-in-the-treatment-of-non-small-cell-lung-cancer-a-propensity-matched-comparative-analysis
#12
Fuqiang Dai, Shenglan Meng, Longyong Mei, Chen Guan, Zheng Ma
BACKGROUND: Video-assisted thoracic surgery (VATS)-assisted lobectomy is widely used to treat non-small cell lung carcinoma (NSCLC). There are no reports concerning the comparison between single-port VATS and two-port VATS in treating NSCLC. This study aimed to compare the perioperative and short-term follow-up results between these two methods for treating NSCLC. METHODS: A retrospective surgical evaluation of patients undergoing either single-port VATS or two-port VATS for NSCLC between January 2013 and June 2015 was conducted...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27867560/should-primary-tumor-be-resected-for-non-small-cell-lung-cancer-with-malignant-pleural-disease-unexpectedly-found-during-operation-a-systemic-review-and-meta-analysis
#13
Yuyang Xu, Nan Chen, Zihuai Wang, Yingyi Zhang, Jiandong Mei, Chengwu Liu, Lunxu Liu
BACKGROUND: Non-small cell lung cancer (NSCLC) with malignant pleural disease (MPD) was considered to be contraindication for surgery, but sometimes MPD was unexpectedly found intraoperatively. There was no consensus on the role of surgical intervention on the primary tumor in patients with MPD. The object of this research was to assess whether exairesis of primary tumor could prolong survival time. METHODS: A systemic research of literature was performed on the databases of PubMed, Embase and Web of Science...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27867550/amide-linked-local-anesthetics-induce-apoptosis-in-human-non-small-cell-lung-cancer
#14
Hong-Wei Wang, Le-Yi Wang, Li Jiang, Su-Ming Tian, Tai-Di Zhong, Xiang-Ming Fang
BACKGROUND: A retrospective analysis of patients undergoing cancer surgery suggested that using local anesthetics could reduce cancer recurrence and improve survival rate. Previous studies have indicated that local anesthetics may induce apoptosis in several kinds of cells in vitro, but the mechanism is unclear. METHODS: Cell viability was analyzed by MTS; reactive oxygen species (ROS), mitochondrial membrane potential (MMP, ∆Ψm), cell cycle distribution, and cell apoptosis assay were detected by flow cytometry; DNA damage was measured by comet assay; cell invasion and migration were observed by microscopy; The expression level of related proteins was detected by western blot assay...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27866516/-gsi-quantitative-parameters-preoperative-diagnosis-of-metastasis-lymph-nodes-in-lung-cancer
#15
Fengfeng Yang, Jie Dong, Xiaolong Yan, Xiuting Wang, Xiaojiao Fu, Tong Zhang
BACKGROUND: Mediastinal involvement in lung cancer is an important prognostic factor affecting survival, and accurate staging of the mediastinum lymph node correctly identifies patients who can benefit the most from surgery. The aim of this study is to investigate the value of dual-energy spectral computed tomography (DEsCT) imaging in differentiating metastatic from non-metastatic lymph nodes in lung cancer. METHODS: Forty-eight patients with non-small cell lung cancer (NSCLC) underwent arterial (AP) and portal venous (PP) phase contrast-enhanced DEsCT imaging followed by surgical treatment...
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27846762/gender-specific-survival-after-surgical-resection-for-early-stage-non-small-cell-lung-cancer
#16
Anders Bugge, Johny Kongerud, Cathrine Brunborg, Steinar Solberg, May Brit Lund
BACKGROUND: Lung cancer is the leading cause of cancer death worldwide. The incidence and mortality rate of lung cancer in women has increased. Studies have indicated that females with non-small cell lung cancer (NSCLC) have better survival than males. We aimed to examine the impact of gender on 1-, 5- and 10-year survival after surgery for stage I and II NSCLC. MATERIALS AND METHODS: During the period 2003-2013, 692 patients operated for stage I and II NSCLC were prospectively registered...
November 16, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27845912/preoperative-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratios-are-independent-prognostic-factors-for-patients-undergoing-lung-cancer-radical-surgery-a-single-institutional-cohort-study
#17
Haidan Lan, Leng Zhou, Dongmei Chi, Qinghua Zhou, XiaoJun Tang, Daxing Zhu, Jianmin Yue, Bin Liu
BACKGROUND: The aim of this study was to assess the prognostic value for NSCLC patients who were scheduled to receive lung cancer radical resection. METHODS: In this cohort study (Dec.2014-Feb.2016), patients with non-small cell lung cancer (NSCLC) who underwent radical lung cancer thoracotomy were enrolled and accessed at postoperative complications, one-year overall survival (OS) and relapse-free survival (RFS). The preoperative PLR and NLR of all patients were calculated based on preoperative complete blood counts...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27826533/liquid-biopsy-in-early-stage-lung-cancer
#18
REVIEW
Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Ana I Robles, Miguel Ángel Molina, María José Faus-Dáder, Miguel Ángel Calleja-Hernández
Lung cancer is the leading cause of cancer-associated deaths worldwide. Surgery is the standard treatment for early-stage non-small cell lung cancer (NSCLC). However, 30% to 80% of these patients will die within 5 yearS of diagnosis. Circulating cell-free DNA (cfDNA) harbors pathologic characteristics of the original tumor, such as gene mutations or epigenetic alterations. Analysis of cfDNA has revolutionized the clinical care of advanced lung cancer patients undergoing targeted therapies. However, the low concentration of cfDNA in the blood of early-stage NSCLC patients has hampered its use for management of early disease...
October 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/27811074/joint-effect-of-airflow-limitation-and-emphysema-on-postoperative-outcomes-in-early-stage-nonsmall-cell-lung-cancer
#19
Sumin Shin, Hye Yun Park, Hyunkyung Kim, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Sang-Won Um, Myung Jin Chung, Hojoong Kim, O Jung Kwon, Jae Ill Zo, Eliseo Guallar, Juhee Cho, Young Mog Shim
This study aims to evaluate the joint effect of severity of airflow limitation and emphysema on postoperative pulmonary complications (PPCs) and overall survival after complete resection in patients with early-stage nonsmall cell lung cancer (NSCLC).We retrospectively studied 413 male patients with pathologic stage I or II NSCLC between 2007 and 2009. Severity of airflow limitation was defined based on forced expiratory volume in 1 s. Emphysema was defined by ≥5% low attenuation area at -950 HU.In multivariable-adjusted analyses, the adjusted odds ratio (aOR) for any PPC, comparing patients with moderate-to-severe airflow limitation to those without airflow limitation, was 2...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27803991/outcomes-of-surgery-for-lung-cancer-in-patients-with-atrial-fibrillation-as-a-preoperative-comorbidity-a-decade-of-experience-at-a-single-institution-in-japan
#20
Ryu Kanzaki, Toru Kimura, Tomohiro Kawamura, Soichiro Funaki, Yasushi Shintani, Masato Minami, Meinoshin Okumura
PURPOSE: To investigate the surgical outcomes of surgery for non-small cell lung cancer (NSCLC) in patients with atrial fibrillation (AF) as a preoperative comorbidity. METHODS: Among 805 patients who underwent surgery for NSCLC, 27 (3.4%) had a history of AF. We analyzed the perioperative and long-term outcomes of these 27 patients. RESULTS: Fourteen patients (52%) had chronic AF and 13 (48%) had paroxysmal AF; being high rates of a comorbid illness...
November 1, 2016: Surgery Today
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