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https://www.readbyqxmd.com/read/28436958/local-clearance-of-senescent-cells-attenuates-the-development-of-post-traumatic-osteoarthritis-and-creates-a-pro-regenerative-environment
#1
Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge, Marco Demaria, Sona Rathod, Alain P Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel David, Darren J Baker, Jan M van Deursen, Judith Campisi, Jennifer H Elisseeff
Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to the senescence-associated secretory phenotype (SASP). Removal of SnCs delays several pathologies and increases healthy lifespan. Aging and trauma are risk factors for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability. Senescent chondrocytes are found in cartilage tissue isolated from patients undergoing joint replacement surgery, yet their role in disease pathogenesis is unknown...
April 24, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28427318/load-application-for-the-contact-mechanics-analysis-and-wear-prediction-of-total-knee-replacement
#2
Jing Zhang, Zhenxian Chen, Ling Wang, Dichen Li, Zhongmin Jin
Tibiofemoral contact forces in total knee replacement have been measured at the medial and lateral sites respectively using an instrumented prosthesis, and predicted from musculoskeletal multibody dynamics models with a reasonable accuracy. However, it is uncommon that the medial and lateral forces are applied separately to replace a total axial load according to the ISO standard in the majority of current finite element analyses. In this study, we quantified the different effects of applying the medial and lateral loads separately versus the traditional total axial load application on contact mechanics and wear prediction of a patient-specific knee prosthesis...
May 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28409132/do-patients-lose-weight-after-total-knee-replacement
#3
Carlos Roberto Schwartsmann, Alexandre Moreira Borges, Geraldo Luiz Schuck de Freitas, Eduardo Zaniol Migon, Gustavo Kaempf de Oliveira, Marcos Wainberg Rodrigues
OBJECTIVE: Several studies show that patients undergoing total knee arthroplasty (TKA) tend to maintain or gain weight after the procedure, which would result in increased wear of the prosthesis and new surgical interventions in a smaller period of time in comparison with patients with adequate body mass index (BMI). The aim of this study was to investigate the effect of TKA surgery on these patients' BMI. METHODS: Initially the records were analyzed, chosen at random from 91 patients undergoing TKA during the period from August 2011 to July 2013...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28387436/2d-3d-reconstruction-of-the-distal-femur-using-statistical-shape-models-addressing-personalized-surgical-instruments-in-knee-arthroplasty-a-feasibility-analysis
#4
Pietro Cerveri, Costanza Sacco, Gianluca Olgiati, Alfonso Manzotti, Guido Baroni
BACKGROUND: Personalized surgical instruments (PSI) have gained success in the domain of total knee replacement, demonstrating clinical outcomes similar or even superior to both traditional and navigated surgeries. The key requirement for prototyping PSI is the availability of the digital bony surface. In this paper, we aim at verifying whether the 2D/3D reconstruction of the distal femur, based on statistical shape models (SSM), grants sufficient accuracy, especially in the condylar regions, to support a PSI technique...
April 7, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28375889/the-main-cause-of-death-following-primary-total-hip-and-knee-replacement-for-osteoarthritis-a-cohort-study-of-26-766-deaths-following-332-734-hip-replacements-and-29-802-deaths-following-384-291-knee-replacements
#5
Linda P Hunt, Yoav Ben-Shlomo, Michael R Whitehouse, Martyn L Porter, Ashley W Blom
BACKGROUND: Patients undergoing primary total joint replacement are selected for surgery and thus (other than having a transiently increased mortality rate postoperatively) have a lower mortality rate than age and sex-matched individuals do. Understanding the causes of death following joint replacement would allow targeted strategies to reduce the risk of death and optimize outcome. We aimed to determine the rates and causes of mortality for patients undergoing primary total hip or knee replacement compared with individuals in the general population who were matched for age and sex...
April 5, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28373981/socs1-regulates-apoptosis-and-inflammation-by-inhibiting-il-4-signaling-in-il-1%C3%AE-stimulated-human-osteoarthritic-chondrocytes
#6
Qiang He, Caihong Sun, Wei Lei, Jianbing Ma
Recently, Suppressor of Cytokine Signaling 1 (SOCS1) was identified as a potential therapeutic target for osteoarthritis (OA) treatment. However, the mechanisms and signaling pathways of SOCS1 in the regulation of OA development are unclear. The purpose of the current study was to investigate whether interleukin- (IL-) 4 was involved in regulatory mechanism of SOCS1 in human osteoarthritic chondrocytes. First, IL-1β was used to stimulate human osteoarthritic chondrocytes isolated from the articular cartilage of OA patients undergoing total knee replacement...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28363197/the-effects-of-postdischarge-telephone-counseling-and-short-message-service-on-the-knee-function-activities-of-daily-living-and-life-satisfaction-of-patients-undergoing-total-knee-replacement
#7
Kyung Hye Park, Mi Ryeong Song
BACKGROUND: No study comparing short message service (SMS) texts and telephone counseling for patients undergoing total knee replacement (TKR) has been reported. PURPOSE: The purpose of the study was to provide postdischarge telephone counseling and SMS texts to TKR patients and to analyze the effects of these services on their knee function (KF), activities of daily living (ADL), and life satisfaction (LS). METHODS: This study used a randomized clinical trial design...
March 30, 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28360504/lateral-facetectomy-decreased-patellofemoral-contact-pressure-in-total-knee-replacement-a-cadaveric-study
#8
Varah Yuenyongviwat, Khanin Iamthanaporn, Theerawit Hongnaparak
BACKGROUND: To study the patellofemoral contact pressure in patellar non-resurfacing total knee replacement after lateral facetectomy in different amounts of bone removal. METHODS: Eight knees from four fresh-frozen whole body cadavers were used for this study. Total knee replacement of all knees was performed by the same surgical technique. The contact pressure was measured and recorded when the knee performed passive motion from full extension to full flexion in native patella, lateral retinacular junction release, 10% lateral facetectomy, and 20% lateral facetectomy...
January 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28351833/impact-of-total-knee-replacement-practice-cost-effectiveness-analysis-of-data-from-the-osteoarthritis-initiative
#9
Bart S Ferket, Zachary Feldman, Jing Zhou, Edwin H Oei, Sita M A Bierma-Zeinstra, Madhu Mazumdar
Objectives To evaluate the impact of total knee replacement on quality of life in people with knee osteoarthritis and to estimate associated differences in lifetime costs and quality adjusted life years (QALYs) according to use by level of symptoms.Design Marginal structural modeling and cost effectiveness analysis based on lifetime predictions for total knee replacement and death from population based cohort data.Setting Data from two studies-Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST)-within the US health system...
March 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28342974/after-total-knee-replacement-younger-patients-demonstrate-superior-balance-control-compared-to-older-patients-when-recovering-from-a-forward-fall
#10
Brian D Street, William Gage
BACKGROUND: National joint replacement registries have reported a substantial growth in younger knee osteoarthritic patients (<55years old) undergoing total knee replacement, however this younger population is generally understudied. Importantly, studies examining experimentally controlled perturbation have shown age-related differences between younger and older healthy adults, whether similar age-related differences exist among total knee replacement patients is unknown. METHODS: A total of 59 participants, including 29 unilateral total knee replacement patients (six-months post-surgery) made up the four experimental groups: 1) younger patient (54...
March 16, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28340610/the-importance-of-informational-clinical-and-personal-support-in-patient-experience-with-total-knee-replacement-a-qualitative-investigation
#11
Laurie J Goldsmith, Nitya Suryaprakash, Ellen Randall, Jessica Shum, Valerie MacDonald, Richard Sawatzky, Samar Hejazi, Jennifer C Davis, Patrick McAllister, Stirling Bryan
BACKGROUND: Total knee arthroplasty (TKA) is the most frequently performed joint replacement surgery in North America. Patient perspectives on TKA have been investigated in various ways, including finding as many as 20% of TKA patients are dissatisfied with their surgical outcomes. Understanding the patient experience with TKA broadly and in relation to patient satisfaction is a key gap in existing literature. METHODS: We report on the qualitative component of a mixed methods prospective cohort study examining patient experience and satisfaction post-TKA for adults in British Columbia, Canada...
March 24, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28336915/a-novel-method-of-evaluating-knee-joint-stability-of-patients-with-knee-osteoarthritis-multiscale-entropy-analysis-with-a-knee-aiming-task
#12
Diange Zhou, Shijie Zhang, Hui Zhang, Long Jiang, Jue Zhang, Jing Fang
Deteriorating knee stability is a local risk factor that reflects the occurrence and aggregative of osteoarthritis (OA). Despite the many biomechanics-based methods for assessing the structural stability of knee joints in clinics, these methods have many limitations. The stability of the knee joint relies on not only biomechanical factors, but also proprioception and the central nervous system. In this study, we attempt to depict the stability of knee joint from a holistic viewpoint, and a novel index of knee joint stability (IKJS) was thus extracted...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331851/predicting-factors-for-allogeneic-blood-transfusion-and-excessive-postoperative-blood-loss-after-single-low-dosage-intra-articular-tranexamic-acid-application-in-total-knee-replacement
#13
Paphon Sa-Ngasoongsong, Siwadol Wongsak, Noratep Kulachote, Pongsthorn Chanplakorn, Patarawan Woratanarat, Viroj Kawinwonggowit
Background. Recently, intra-articular tranexamic acid (IA-TXA) application has become a popular method for perioperative blood loss (PBL) reduction in total knee replacement (TKR). Nevertheless, through our knowledge, no previous studies had shown the correlation perioperative factors and the risk of excessive PBL or need of blood transfusion (BT) after IA-TXA. Materials and Methods. A retrospective study was conducted in patients underwent 299 primary TKRs, using IA-TXA, during 2-year period (2013-2014). Patient's characteristic and perioperative data were reviewed and collected...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28331362/anesthesia-for-the-patient-undergoing-total-knee-replacement-current-status-and-future-prospects
#14
REVIEW
Zachary A Turnbull, Dahniel Sastow, Gregory P Giambrone, Tiffany Tedore
Total knee arthroplasty (TKA) has become one of the most common orthopedic surgical procedures performed nationally. As the population and surgical techniques for TKAs have evolved over time, so have the anesthesia and analgesia used for these procedures. General anesthesia has been the dominant form of anesthesia utilized for TKA in the past, but regional anesthetic techniques are on the rise. Multiple studies have shown the potential for regional anesthesia to improve patient outcomes, such as a decrease in intraoperative blood loss, length of stay, and patient mortality...
2017: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/28330380/rehabilitation-after-total-joint-replacement-a-scoping-study
#15
Deborah L Snell, Julia Hipango, K Anne Sinnott, Jennifer A Dunn, Alastair Rothwell, C Jean Hsieh, Gerben DeJong, Gary Hooper
PURPOSE: The evidence supporting rehabilitation after joint replacement, while vast, is of variable quality making it difficult for clinicians to apply the best evidence to their practice. We aimed to map key issues for rehabilitation following joint replacement, highlighting potential avenues for new research. MATERIALS AND METHODS: We conducted a scoping study including research published between January 2013 and December 2016, evaluating effectiveness of rehabilitation following hip and knee total joint replacement...
March 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28326399/total-knee-replacement-for-tricompartmental-arthritis-in-a-patient-with-a-below-knee-amputation-after-a-previous-closing-wedge-high-tibial-osteotomy
#16
Mark A Fleming, Michael C Dixon
This is a report of a 64-year-old man who had undergone a high tibial osteotomy (HTO) 17 years ago of his right knee for medial compartment osteoarthritis; 5 days later, he received a below-knee amputation owing to a missed popliteal artery injury at the time of the HTO. We elected to perform a total knee replacement (TKR) for progressive arthritis of the ipsilateral knee 17 years after the transtibial amputation. Although there is a plethora of literature regarding TKR in the contralateral knee of amputees, there is a paucity of data of TKR in the ipsilateral knee...
June 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28325693/surgical-technique-and-clinical-outcomes-of-retrograde-osteochondral-autograft-transfer-for-osteochondral-lesions-of-the-tibial-plateau
#17
Hiromitsu Yabumoto, Yasuaki Nakagawa, Shogo Mukai, Takahiko Saji, Takashi Nakamura
PURPOSE: To present the surgical technique, clinical outcomes, and poor prognostic factors of arthroscopic retrograde osteochondral autograft transfer of the tibial plateau. METHODS: Twelve patients (6 men, 6 women; mean age, 38.7 years) with tibial plateau osteochondral lesions underwent surgery. The primary diseases were osteonecrosis in 4 cases, cartilage injuries in 6, and postfractures of the tibial plateau in 2. Clinical outcomes were evaluated preoperatively and postoperatively according to the International Knee Documentation Committee score and the Japanese Orthopaedic Association score...
March 18, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28320058/regional-differences-between-perisynovial-and-infrapatellar-adipose-tissue-depots-and-their-response-to-class-ii-and-iii-obesity-in-patients-with-oa
#18
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, A Hamish W R Simpson
OBJECTIVE: Obesity is associated with an increased risk of developing Osteoarthritis (OA), which is postulated to be secondary to inflammation from adipose tissue (AT). There are peri-articular adipose depots in synovial joints, the association of this tissue with OA has not been extensively explored. The aim of this study was to investigate differences in local AT depots in knees with OA and changes related to class II and III obesity. METHODS: Synovium and the infrapatellar fat pad (IPFP) were collected during total knee replacement from 69 patients with end-stage OA...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28319157/subchondral-bone-histology-and-grading-in-osteoarthritis
#19
Olli-Matti Aho, Mikko Finnilä, Jerome Thevenot, Simo Saarakkala, Petri Lehenkari
OBJECTIVE: Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New evidence has shifted the paradigm towards a system biology approach, where also the surrounding tissue, especially bone is studied more vigorously. However, the histological features of subchondral bone are only poorly characterized in current histological grading scales of OA. The aim of this study is to specifically characterize histological changes occurring in subchondral bone at different stages of OA and propose a simple grading system for them...
2017: PloS One
https://www.readbyqxmd.com/read/28316350/peek-and-cfr-peek-as-alternative-bearing-materials-to-uhmwpe-in-a-fixed-bearing-total-knee-replacement-an-experimental-wear-study
#20
Claire L Brockett, Silvia Carbone, John Fisher, Louise M Jennings
New bearing materials for total joint replacement have been explored as the need to improve longevity and enhance performance is driven by the changing demands of the patient demographic. Carbon-reinforced PEEK has demonstrated good wear characteristics in experimental wear simulation in both simple geometry pin-on-plate studies and in total hip joint replacement. Carbon reinforced PEEK CFR-PEEK has the potential to reduce tibial insert thickness and preserve bone in the knee. This study investigated the wear performance of PEEK and CFR-PEEK in a low conformity total knee replacement configuration...
March 15, 2017: Wear: An International Journal on the Science and Technology of Friction Lubrication and Wear
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